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Kari Alitalo

Research Profile

Chemicals & Drugs

Living Beings

Mouse

Phenomena

Lymphangiogenesis

Anatomy

Physiology

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Neovascularization, Pathologic

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Molecular Sequence Data

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Publications

TOP 3
Jean-Leon Thomas; Kasey Baker; Charles Calvo; Anne C Eichmann; Jinah Han; Harri Nurmi; Kari Alitalo
Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells.
Lauri Eklund; Maija Bry; Kari Alitalo
Mouse models for studying angiogenesis and lymphangiogenesis in cancer.
Jacques A Villefranc; Georgia Zarkada; John C Moore; Stefania Nicoli; Kari Alitalo; Katie Bentley; Holger Gerhardt; Michael Jeltsch; Nathan D Lawson
A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.

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All Publications

2013: Jean-Leon Thomas; Kasey Baker; Charles Calvo; Anne C Eichmann; Jinah Han; Harri Nurmi; Kari Alitalo
Interactions between VEGFR and Notch signaling pathways in endothelial and neural cells.
Cellular and molecular life sciences : CMLS 2013;70(10):1779-92.
2013: Lauri Eklund; Maija Bry; Kari Alitalo
Mouse models for studying angiogenesis and lymphangiogenesis in cancer.
Molecular oncology 2013;7(2):259-82.
2013: Jacques A Villefranc; Georgia Zarkada; John C Moore; Stefania Nicoli; Kari Alitalo; Katie Bentley; Holger Gerhardt; Michael Jeltsch; Nathan D Lawson
A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development.
Development (Cambridge, England) 2013;140(7):1497-506.
2013: Peter Baluk; Kristina Bry; Maija Bry; Anna Hogmalm; Kari Alitalo; Donald M McDonald
Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways.
The American journal of pathology 2013;182(4):1434-47.
2013: René Hägerling; Ralf H Adams; Kari Alitalo; Martin Andreas; Volker Andresen; Harri Nurmi; Cathrin Pollmann; Christian Schmidt; Stefan Schulte-Merker; Friedemann Kiefer
A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy.
The EMBO journal 2013;32(5):629-44.
2013: C E Markhus; Olav Tenstad; M Wagner; Kari Alitalo; T V Karlsen; Ø S Svendsen; Helge Wiig
Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema.
Arteriosclerosis, thrombosis, and vascular biology 2013;33(2):266-74.
2013: Andrey Anisimov; Chulhee Choi; Elisabetta Dejana; Emília Ilona Gaál; Eun Chun Han; Tanja Holopainen; Michael Jeltsch; Salla Keskitalo; Gou Young Koh; Young Jun Koh; Petra Korpisalo; Veli-Matti Leppänen; Fabrizio Orsenigo; Pipsa Saharinen; Tuomas Tammela; Denis Tvorogov; Seppo Ylä-Herttuala; Annamari Alitalo; Yuri An; Kari Alitalo
Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis.
Circulation 2013;127(4):424-34.
2013: Taina A Partanen; Anne Pitkäranta; Päivi Salminen; Pia Vuola; Kari Alitalo; Sanna-Kaisa Häkkinen; Krista Honkonen; Suvi Jauhiainen; Jouko Lohi; Seppo Ylä-Herttuala
Neuropilin-2 and vascular endothelial growth factor receptor-3 are up-regulated in human vascular malformations.
Angiogenesis 2013;16(1):137-46.
2012: Jenni Huusko; Line Lottonen; Mari Merentie; Atsushi Miyanohara; Pasi Tavi; Kari Alitalo; Andrey Anisimov; Erika Gurzeler; Seppo Ylä-Herttuala
AAV9-mediated VEGF-B gene transfer improves systolic function in progressive left ventricular hypertrophy.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(12):2212-21.
2012: Minna Sopo; Laura Tuppurainen; Pasi Tuunanen; Kari Alitalo; Maarit Anttila; Kirsi Hamalainen; Seppo Heinonen; Jonna K Koponen; Veli-Matti Kosma; Svetlana Laidinen; Anniina Laurema; Hanna Sallinen; Seppo Yla-Herttuala
Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma.
International journal of cancer. Journal international du cancer 2012;131(10):2394-401.
2012: Kari Alitalo
A radical view of pathological vasculature.
Cell metabolism 2012;16(3):287-8.
2012: Susan N Thomas; Kari Alitalo; Emma L Kuan; Miriella Pasquier; Gwendalyn J Randolph; Joseph M Rutkowski; Melody Swartz
Impaired humoral immunity and tolerance in K14-VEGFR-3-Ig mice that lack dermal lymphatic drainage.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(5):2181-90.
2012: Rodrigo Leite de Oliveira; Annelies Peeters; Carmen Roncal; Evelyne Tack; Yukiji Takeda; Lorenzo Veschini; Kari Alitalo; Andrey Anisimov; Myriam Baes; Peter Carmeliet; Koen Debackere; Sofie Deschoemaeker; Daniela Dettori; Jan D'Hooge; Veronica Finisguerra; Anne-Theres Henze; Matthias Hofmann; Yannick Jönsson; Massimiliano Mazzone
Gene-targeting of Phd2 improves tumor response to chemotherapy and prevents side-toxicity.
Cancer cell 2012;22(2):263-77.
2012: Tanja Holopainen; Dennis Jones; Vanessa López-Alpuche; Wang Min; Taina Pihlajaniemi; Denis Tvorogov; Zoltan Wiener; Wei Zheng; Leif C Andersson; Gabriela D'Amico; Yun He; Ritva Heljasvaara; Kari Alitalo
Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth.
Cancer research 2012;72(14):3512-21.
2012: Johannes Keuschnigg; Marko Salmi; Tiina Salminen; Denis Tvorogov; Kari Alitalo; Kati Elima; Sirpa Jalkanen
PV-1 is recognized by the PAL-E antibody and forms complexes with NRP-1.
Blood 2012;120(1):232-5.
2012: Anna-Katharina Meinecke; Nadine Nagy; Véronique Orian-Rousseau; Helene Rundqvist; Katrin Schrödter; Dirk Theegarten; Annika Zimmermann; Kari Alitalo; Olaf Anhenn; Joachim Fandrey; Jens W Fischer; Iris Helfrich; Randall S Johnson; Santina Kirmse; Ralph Klose; Gabriela D'Amico Lago; Christian Stockmann
Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis.
Blood 2012;119(24):5931-42.
2012: Riikka Pietilä; Kristina H Pulkki; Pipsa Saharinen; Tuomas Tammela; Miikka Vikkula; Jaakko Kangas; Gou Young Koh; Nisha Limaye; Marjut Nätynki; Kari Alitalo; Lauri Eklund
Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses.
Journal of cell science 2012;125(Pt 9):2212-23.
2012: Inés Martínez-Corral; David Olmeda; Kari Alitalo; Rodrigo Diéguez-Hurtado; Tuomas Tammela; Sagrario Ortega
In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(16):6223-8.
2012: J Weltner; Kari Alitalo; A Anisimov; Timo Otonkoski; Ras Trokovic
Induced pluripotent stem cell clones reprogrammed via recombinant adeno-associated virus-mediated transduction contain integrated vector sequences.
Journal of virology 2012;86(8):4463-7.
2012: Tanja Holopainen; Gou Young Koh; Anita Lampinen; Ching Ching Leow; Marja Lohela; Pipsa Saharinen; Raija Sormunen; Tuomas Tammela; Seppo Ylä-Herttuala; Georgia Zarkada; Andrey Anisimov; Laura E Benjamin; Gabriela D'Amico; Lauri Eklund; Hanna Heloterä; Kari Alitalo
Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis.
Journal of the National Cancer Institute 2012;104(6):461-75.
2012: Maurice S Brozzo; Kaisa Kisko; Veli-Matti Leppänen; Thomas Schleier; Fritz K Winkler; Sasa Bjelic; Kari Alitalo; Kurt Ballmer-Hofer
Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization.
Blood 2012;119(7):1781-8.
2012: Marius R Robciuc; Paulina Skrobuk; Matti Jauhiainen; Heikki A Koistinen; Vesa M Olkkonen; Kari Alitalo; Andrey Anisimov; Robert H Eckel; Christian Ehnholm
Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes.
PloS one 2012;7(10):e46212.
2012: Fréderic Larrieu-Lahargue; Dean Y Li; Alana L Welm; Kari Alitalo; Andreas Bikfalvi; Marion Bouchecareilh; Patrick Auguste
Blocking Fibroblast Growth Factor receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis.
PloS one 2012;7(6):e39540.
2012: Momina Mirza; Mei-Fong Pang; Lennart Philipson; Kari Alitalo; Jonas Fuxe; Paula Haiko; Tuomas Tammela; Mohamad Amr Zaini; Kerstin Sollerbrant
Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice.
PloS one 2012;7(5):e37523.
2011: Yukiji Takeda; Mathias Wenes; Zhen W Zhuang; Carmen Roncal; Yoshihiko Saito; Jens Serneels; Michael Simons; Mario Leonardo Squadrito; Kari Alitalo; Andrey Anisimov; Tapan Bhattacharyya; Françoise Bruyère; Sandra Costa; Michele De Palma; Estelle Delamarre; Sofie Deschoemaeker; Veronica Finisguerra; Bernard Gallez; Alexander Hamm; Benedicte F Jordan; Rodrigo Leite de Oliveira; Julie Magat; Patrick Maxwell; Massimiliano Mazzone
Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis.
Nature 2011;479(7371):122-6.
2011: Tuomas Tammela; Denis Tvorogov; Seppo Ylä-Herttuala; Georgia Zarkada; Wei Zheng; Evelyn Aranda; Anne Eichmann; Claudio A Franco; Marcus Fruttiger; Holger Gerhardt; Krista Heinolainen; Lars Jakobsson; Taija Mäkinen; Naoyuki Miura; Aino Murtomäki; Harri Nurmi; Jeffrey W Pollard; Kari Alitalo
VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling.
Nature cell biology 2011;13(10):1202-13.
2011: M Piltonen; Anu Planken; Mart Saarma; Timo Myöhänen; Kari Alitalo; Jaan-Olle Andressoo; P Auvinen; Anna-Liisa Hänninen; O Leskelä; Pekka T Männistö
Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo.
Neuroscience 2011;192():550-63.
2011: Kaisa Kisko; Veli-Matti Leppänen; Andreas Menzel; John Missimer; Thomas Schleier; Thomas Walzthoeni; Ruedi Aebersold; Kari Alitalo; Maurice S Brozzo; Kurt Ballmer-Hofer
Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(9):2980-6.
2011: Wei Zheng; Andrey Anisimov; Tanja Holopainen; S Kaijalainen; Terhi Karpanen; Kaisa Lehti; Tuomas Tammela; Masahiro Yamamoto; Seppo Ylä-Herttuala; Kari Alitalo
Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor.
Blood 2011;118(4):1154-62.
2011: Pipsa Saharinen; Petri Bono; Lauri Eklund; Kristina Pulkki; Kari Alitalo
VEGF and angiopoietin signaling in tumor angiogenesis and metastasis.
Trends in molecular medicine 2011;17(7):347-62.
2011: Carmen Ruiz de Almodovar; Inmaculada Segura; Geraldine Strasser; Marc Tessier-Lavigne; Stefan Vinckier; Leona Aerts; Kari Alitalo; Valerie Castellani; Frederic Charron; Alain Chedotal; Cathy Coulon; Nicolas Delattin; Pierre Fabre; Coralie Fouquet; Chengua Gu; Patrick C G Haddick; Jody Haigh; Ellen Knevels; Christian Lange; Won-Jong Oh; Peter Carmeliet
VEGF mediates commissural axon chemoattraction through its receptor Flk1.
Neuron 2011;70(5):966-78.
2011: Pipsa Saharinen; Kari Alitalo
The yin, the yang, and the angiopoietin-1.
The Journal of clinical investigation 2011;121(6):2157-9.
2011: Marie Gottar-Guillier; Francis Dodeller; Dieter Huesken; Vadim Iourgenko; Craig Mickanin; Mark Labow; Samuel Gaveriaux; Bernd Kinzel; Matthias Mueller; Kari Alitalo; Amanda Littlewood-Evans; Bruno Cenni
The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(10):6014-23.
2011: Tanja Holopainen; Maija Bry; Kari Alitalo; Anne Saaristo
Perspectives on lymphangiogenesis and angiogenesis in cancer.
Journal of surgical oncology 2011;103(6):484-8.
2011: Kanako Hosono; Tatsunori Suzuki; Hideaki Tamaki; Hiroyuki Sakagami; Izumi Hayashi; Shuh Narumiya; Kari Alitalo; Masataka Majima
Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(5):1049-58.
2011: Reto Huggenberger; Shoib S Siddiqui; Daniela Brander; Stefan Ullmann; Kathrin Zimmermann; Maria Antsiferova; Sabine Werner; Kari Alitalo; Michael Detmar
An important role of lymphatic vessel activation in limiting acute inflammation.
Blood 2011;117(17):4667-78.
2011: Charles-Félix Calvo; Romain H Fontaine; Jihane Soueid; Tuomas Tammela; Taija Makinen; Clara Alfaro-Cervello; Fabien Bonnaud; Andres Miguez; Lucile Benhaim; Yunling Xu; Maria-José Barallobre; Imane Moutkine; Johannes Lyytikkä; Turgut Tatlisumak; Bronislaw Pytowski; Bernard Zalc; William Richardson; Nicoletta Kessaris; Jose Manuel Garcia-Verdugo; Kari Alitalo; Anne Eichmann; Jean-Léon Thomas
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis.
Genes & development 2011;25(8):831-44.
2011: Camilla Norrmén; Tuomas Tammela; Tatiana V Petrova; Kari Alitalo
Biological basis of therapeutic lymphangiogenesis.
Circulation 2011;123(12):1335-51.
2011: Samer M Hussein; Nizar N Batada; Sanna Vuoristo; Reagan W Ching; Reija Autio; Elisa Närvä; Siemon Ng; Michel Sourour; Riikka Hämäläinen; Cia Olsson; Karolina Lundin; Milla Mikkola; Ras Trokovic; Michael Peitz; Oliver Brüstle; David P Bazett-Jones; Kari Alitalo; Riitta Lahesmaa; Andras Nagy; Timo Otonkoski
Copy number variation and selection during reprogramming to pluripotency.
Nature 2011;471(7336):58-62.
2011: Ela Elyada; Ariel Pribluda; Robert E Goldstein; Yael Morgenstern; Guy Brachya; Gady Cojocaru; Irit Snir-Alkalay; Ido Burstain; Rebecca Haffner-Krausz; Steffen Jung; Zoltan Wiener; Kari Alitalo; Moshe Oren; Eli Pikarsky; Yinon Ben-Neriah
CKIα ablation highlights a critical role for p53 in invasiveness control.
Nature 2011;470(7334):409-13.
2011: Markku Lähteenvuo; Krista Honkonen; Tomi Tervala; Tuomas Tammela; Erkki Suominen; Johanna Lähteenvuo; Ivana Kholová; Kari Alitalo; Seppo Ylä-Herttuala; Anne Saaristo
Growth factor therapy and autologous lymph node transfer in lymphedema.
Circulation 2011;123(6):613-20.
2011: Tuomas Tammela; Anne Saaristo; Tanja Holopainen; Seppo Ylä-Herttuala; Leif C Andersson; Susanna Virolainen; Ilkka Immonen; Kari Alitalo
Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis.
Science translational medicine 2011;3(69):69ra11.
2011: Veli-Matti Leppänen; Michael Jeltsch; Andrey Anisimov; Denis Tvorogov; Kukka Aho; Nisse Kalkkinen; Pyry Toivanen; Seppo Ylä-Herttuala; Kurt Ballmer-Hofer; Kari Alitalo
Structural determinants of vascular endothelial growth factor-D receptor binding and specificity.
Blood 2011;117(5):1507-15.
2011: H Sallinen; M Anttila; O Gröhn; J Koponen; K Hämäläinen; I Kholova; V-M Kosma; S Heinonen; Kari Alitalo; Seppo Ylä-Herttuala
Cotargeting of VEGFR-1 and -3 and angiopoietin receptor Tie2 reduces the growth of solid human ovarian cancer in mice.
Cancer gene therapy 2011;18(2):100-9.
2011: Kari Alitalo
The lymphatic vasculature in disease.
Nature medicine 2011;17(11):1371-80.
2011: Hanseul Yang; Chan Kim; Min-Ju Kim; Reto A Schwendener; Kari Alitalo; Warren Heston; Injune Kim; Wun-Jae Kim; Gou Young Koh
Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer.
Molecular cancer 2011;10():36.
2011: Evisa Gjini; Liesbeth Hekking; Axel Küchler; Pipsa Saharinen; Erno Wienholds; Jan Andries Post; Kari Alitalo; Stefan Schulte-Merker
Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity.
Disease models & mechanisms 2011;4(1):57-66.
2010: Minah Kim; Young Jun Koh; Kyung Eun Kim; Bong Ihn Koh; Do-Hyun Nam; Kari Alitalo; Injune Kim; Gou Young Koh
CXCR4 signaling regulates metastasis of chemoresistant melanoma cells by a lymphatic metastatic niche.
Cancer research 2010;70(24):10411-21.
2010: Denis Tvorogov; Andrey Anisimov; Wei Zheng; Veli-Matti Leppänen; Tuomas Tammela; Simonas Laurinavicius; Wolfgang Holnthoner; Hanna Heloterä; Tanja Holopainen; Michael Jeltsch; Nisse Kalkkinen; Hilkka Lankinen; Päivi M Ojala; Kari Alitalo
Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization.
Cancer cell 2010;18(6):630-40.
2010: David J McBride; Arto K Orpana; C Sotiriou; Heikki Joensuu; Philip J Stephens; Laura J Mudie; Eija Hämäläinen; Lucy A Stebbings; Leif C Andersson; Adrienne M Flanagan; Virginie Durbecq; Michail Ignatiadis; Olli Kallioniemi; Caroline A Heckman; Kari Alitalo; Henrik Edgren; P Andrew Futreal; Michael R Stratton; Peter J Campbell
Use of cancer-specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors.
Genes, chromosomes & cancer 2010;49(11):1062-9.
2010: Karlien Hermans; Dontcho Kerjaschki; Annelii Ny; Fabrizio Orsenigo; Bin Ren; Stefan Schulte-Merker; Michael Simons; Wouter Vandevelde; Wei Zheng; Kari Alitalo; Kristof Anthonis; Monica Autiero; Filip Claes; Frank De Smet; Elisabetta Dejana; Mieke Dewerchin; Ilse Geudens; Evisa Gjini; Peter Carmeliet
Role of synectin in lymphatic development in zebrafish and frogs.
Blood 2010;116(17):3356-66.
2010: Maija Bry; Riikka Kivelä; Tanja Holopainen; Andrey Anisimov; Tuomas Tammela; Jarkko Soronen; Johanna Silvola; Antti Saraste; Michael Jeltsch; Petra Korpisalo; Peter Carmeliet; Karl B Lemström; Masabumi Shibuya; Seppo Ylä-Herttuala; Leena Alhonen; Eero Mervaala; Leif C Andersson; Juhani Knuuti; Kari Alitalo
Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation.
Circulation 2010;122(17):1725-33.
2010: Nami Sugiyama; Markku Varjosalo; Pipsa Meller; Jouko Lohi; Marko Hyytiäinen; Sami Kilpinen; Olli Kallioniemi; Signe Ingvarsen; Lars H Engelholm; Jussi Taipale; Kari Alitalo; Jorma Keski-Oja; Kaisa Lehti
Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation.
Cancer research 2010;70(20):7851-61.
2010: Fei Zhou; Zai Chang; Luqing Zhang; Young-Kwon Hong; Bin Shen; Bo Wang; Fan Zhang; Guangming Lu; Denis Tvorogov; Kari Alitalo; Brian A Hemmings; Zhongzhou Yang; Yulong He
Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development.
The American journal of pathology 2010;177(4):2124-33.
2010: Reto Huggenberger; Stefan Ullmann; Steven T Proulx; Bronislaw Pytowski; Kari Alitalo; Michael Detmar
Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation.
The Journal of experimental medicine 2010;207(10):2255-69.
2010: Nami Sugiyama; Markku Varjosalo; Pipsa Meller; Jouko Lohi; Kui Ming Chan; Zhongjun Zhou; Kari Alitalo; Jussi Taipale; Jorma Keski-Oja; Kaisa Lehti
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(36):15786-91.
2010: Mikko A I Keränen; Antti I Nykänen; Rainer Krebs; Katri Pajusola; Raimo Tuuminen; Kari Alitalo; Karl B Lemström
Cardiomyocyte-targeted HIF-1alpha gene therapy inhibits cardiomyocyte apoptosis and cardiac allograft vasculopathy in the rat.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010;29(9):1058-66.
2010: Gabriela D'Amico; Kari Alitalo
Inside bloody lymphatics.
Blood 2010;116(4):512-3.
2010: Pavel Uhrin; Jan Zaujec; Johannes M Breuss; Damla Olcaydu; Peter Chrenek; Hannes Stockinger; Elke Fuertbauer; Markus Moser; Paula Haiko; Reinhard Fässler; Kari Alitalo; Bernd R Binder; Dontscho Kerjaschki
Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation.
Blood 2010;115(19):3997-4005.
2010: Pipsa Saharinen; Hanna Helotera; Juho J Miettinen; Camilla Norrmen; Gabriela D'Amico; Michael Jeltsch; Tobias Langenberg; Wouter Vandevelde; Annelii Ny; Mieke Dewerchin; Peter Carmeliet; Kari Alitalo
Claudin-like protein 24 interacts with the VEGFR-2 and VEGFR-3 pathways and regulates lymphatic vessel development.
Genes & development 2010;24(9):875-80.
2010: Pipsa Saharinen; Maija Bry; Kari Alitalo
How do angiopoietins Tie in with vascular endothelial growth factors?
Current opinion in hematology 2010;17(3):198-205.
2010: Antti I Nykänen; Henrik Sandelin; Rainer Krebs; Mikko A I Keränen; Raimo Tuuminen; Terhi Kärpänen; Yan Wu; Bronislaw Pytowski; Petri K Koskinen; Seppo Ylä-Herttuala; Kari Alitalo; Karl B Lemström
Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts.
Circulation 2010;121(12):1413-22.
2010: Joseph M Rutkowski; Carl Erik Markhus; Christina C Gyenge; Kari Alitalo; Helge Wiig; Melody Swartz
Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema.
The American journal of pathology 2010;176(3):1122-9.
2010: Tuomas Tammela; Kari Alitalo
Lymphangiogenesis: Molecular mechanisms and future promise.
Cell 2010;140(4):460-76.
2010: Veli-Matti Leppänen; Andrea E Prota; Michael Jeltsch; Andrey Anisimov; Nisse Kalkkinen; Tomas Strandin; Hilkka Lankinen; Adrian Goldman; Kurt Ballmer-Hofer; Kari Alitalo
Structural determinants of growth factor binding and specificity by VEGF receptor 2.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(6):2425-30.
2010: Gabriela D'Amico; Emilia Anne Korhonen; Marika Waltari; Pipsa Saharinen; Pirjo Laakkonen; Kari Alitalo
Loss of endothelial Tie1 receptor impairs lymphatic vessel development-brief report.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(2):207-9.
2010: Camilla Norrmén; Wouter Vandevelde; Annelii Ny; Pipsa Saharinen; Massimiliano Gentile; Guttorm Haraldsen; Pauli Puolakkainen; Eugene Lukanidin; Mieke Dewerchin; Kari Alitalo; Tatiana V Petrova
Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity.
Blood 2010;115(4):906-9.
2010: Yunling Xu; Li Yuan; Judy Mak; Luc Pardanaud; Maresa Caunt; Ian Kasman; Bruno Larrivée; Raquel Del Toro; Steven Suchting; Alexander Medvinsky; Jillian Silva; Jian Yang; Jean-Léon Thomas; Alexander W Koch; Kari Alitalo; Anne Eichmann; Anil Bagri
Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3.
The Journal of cell biology 2010;188(1):115-30.
2010: Imke Albrecht; Lucie Kopfstein; Karin Strittmatter; Tibor Schomber; Annelie Falkevall; Carolina E Hagberg; Pascal Lorentz; Michael Jeltsch; Kari Alitalo; Ulf Eriksson; Gerhard Christofori; Kristian Pietras
Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis.
PloS one 2010;5(11):e14109.
2010: Harold Kim; Vicky P K H Nguyen; Tatiana V Petrova; Maribelle Cruz; Kari Alitalo; Daniel J Dumont
Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signature.
BMC developmental biology 2010;10():72.
2009: Benjamin M Hogan; Robert Herpers; Merlijn Witte; Hanna Heloterä; Kari Alitalo; Henricus J Duckers; Stefan Schulte-Merker
Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.
Development (Cambridge, England) 2009;136(23):4001-9.
2009: Carla Mouta-Bellum; Aleksander Kirov; Laura Miceli-Libby; Maria L Mancini; Tatiana V Petrova; Lucy Liaw; Igor Prudovsky; Philip E Thorpe; Naoyuki Miura; Lewis C Cantley; Kari Alitalo; David A Fruman; Calvin P H Vary
Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(10):2670-9.
2009: Andrey Anisimov; Annamari Alitalo; Petra Korpisalo; Jarkko Soronen; S Kaijalainen; Veli-Matti Leppänen; Michael Jeltsch; Seppo Ylä-Herttuala; Kari Alitalo
Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle.
Circulation research 2009;104(11):1302-12.
2009: Tanja Holopainen; Huilian Huang; Caiping Chen; Kyung Eun Kim; Luqing Zhang; Fei Zhou; Wencan Han; Chaojun Li; Jun Yu; Jun Wu; Gou Young Koh; Kari Alitalo; Yulong He
Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment.
Cancer research 2009;69(11):4656-64.
2009: KATARU RAGHU; Keehoon Jung; Cholsoon Jang; Hanseul Yang; Reto Schwendener; Jung Eun Baik; Seung Hyun Han; Kari Alitalo; Gou Young Koh
Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution.
Blood 2009;113(22):5650-9.
2009: Camilla Norrmén; Konstantin I Ivanov; Jianpin Cheng; Nadine Zangger; Mauro Delorenzi; Muriel Jaquet; Naoyuki Miura; Pauli Puolakkainen; Valerie Horsley; Junhao Hu; Hellmut G Augustin; Seppo Ylä-Herttuala; Kari Alitalo; Tatiana V Petrova
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1.
The Journal of cell biology 2009;185(3):439-57.
2009: Agnes Machnik; Wolfgang Neuhofer; Jonathan Jantsch; Anke Dahlmann; Tuomas Tammela; Katharina Machura; Joon-Keun Park; Franz-Xaver Beck; Dominik N Müller; Wolfgang Derer; Jennifer Goss; Agata Ziomber; Peter Dietsch; Hubertus Wagner; Nico van Rooijen; Armin Kurtz; Karl F Hilgers; Kari Alitalo; Kai-Uwe Eckardt; Friedrich C Luft; Dontscho Kerjaschki; Jens Titze
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Nature medicine 2009;15(5):545-52.
2009: Raimo Tuuminen; Antti I Nykänen; Rainer Krebs; Jarkko Soronen; Katri Pajusola; Mikko A I Keränen; Petri K Koskinen; Kari Alitalo; Karl B Lemström
PDGF-A, -C, and -D but not PDGF-B increase TGF-beta1 and chronic rejection in rat cardiac allografts.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(5):691-8.
2009: Marja Lohela; Maija Bry; Tuomas Tammela; Kari Alitalo
VEGFs and receptors involved in angiogenesis versus lymphangiogenesis.
Current opinion in cell biology 2009;21(2):154-65.
2009: Hellmut G Augustin; Gou Young Koh; Gavin Thurston; Kari Alitalo
Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system.
Nature reviews. Molecular cell biology 2009;10(3):165-77.
2009: Johanna E Lähteenvuo; Markku T Lähteenvuo; Antti Kivelä; Carolina Rosenlew; Annelie Falkevall; Joakim Klar; Tommi Heikura; Tuomas T Rissanen; Elisa Vähäkangas; Petra Korpisalo; Berndt Enholm; Peter Carmeliet; Kari Alitalo; Ulf Eriksson; Seppo Ylä-Herttuala
Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms.
Circulation 2009;119(6):845-56.
2009: Hanna Sallinen; Maarit Anttila; Johanna Narvainen; Jonna K Koponen; Kirsi Hamalainen; Ivana Kholova; Tommi Heikura; Pyry Toivanen; Veli-Matti Kosma; Seppo Heinonen; Kari Alitalo; Seppo Yla-Herttuala
Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(2):278-84.
2009: Valerie L R M Verstraeten; Wolfgang Holnthoner; Maurice A M van Steensel; Joep C J M Veraart; Reno S Bladergroen; Caroline A Heckman; Salla Keskitalo; Jorge Frank; Kari Alitalo; Michel van Geel; Peter M Steijlen
Functional analysis of FLT4 mutations associated with Nonne-Milroy lymphedema.
The Journal of investigative dermatology 2009;129(2):509-12.
2008: Scherise A Mitchell-Jordan; Tanja Holopainen; Shuxun Ren; Sujing Wang; Sarah Warburton; Michael J Zhang; Kari Alitalo; Yibin Wang; Thomas M Vondriska
Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy.
Circulation research 2008;103(12):1359-62.
2008: Marja Lohela; Hanna Heloterä; Paula Haiko; Daniel J Dumont; Kari Alitalo
Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues.
The American journal of pathology 2008;173(6):1891-901.
2008: Petra Korpisalo; Henna Karvinen; Tuomas T Rissanen; Johanna Kilpijoki; Varpu Marjomäki; Peter Baluk; Donald M McDonald; Yihai Cao; Ulf Eriksson; Kari Alitalo; Seppo Ylä-Herttuala
Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels.
Circulation research 2008;103(10):1092-9.
2008: Terhi Karpanen; Maija Bry; Hanna M Ollila; Tuulikki Seppänen-Laakso; Erkki Liimatta; Hanna Leskinen; Riikka Kivelä; Teemu Helkamaa; Mari Merentie; Michael Jeltsch; Kristian J Paavonen; Leif C Andersson; Eero Mervaala; Ilmo E Hassinen; Seppo Ylä-Herttuala; Matej Oresic; Kari Alitalo
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy.
Circulation research 2008;103(9):1018-26.
2008: Jeremy B Burton; Saul J Priceman; James L Sung; Ebba Brakenhielm; Dong Sung An; Bronislaw Pytowski; Kari Alitalo; Lily Wu
Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis.
Cancer research 2008;68(19):7828-37.
2008: Anna Kirjavainen; Marilin Sulg; Florian Heyd; Kari Alitalo; Seppo Ylä-Herttuala; Tarik Möröy; Tatiana V Petrova; Ulla Pirvola
Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia.
Developmental biology 2008;322(1):33-45.
2008: Terhi Karpanen; Kari Alitalo
VEGF-D: a modifier of embryonic lymphangiogenesis.
Blood 2008;112(5):1547-8.
2008: Xuri Li; Marc Tjwa; Inge Van Hove; Berndt Enholm; Elke Neven; Karri Paavonen; Michael Jeltsch; Toni Diez Juan; Richard E Sievers; Emmanuel Chorianopoulos; Hiromichi Wada; Maarten Vanwildemeersch; Agnes Noel; Jean-Michel Foidart; Matthew L Springer; Georges von Degenfeld; Mieke Dewerchin; Helen M Blau; Kari Alitalo; Ulf Eriksson; Peter Carmeliet; Lieve Moons
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(9):1614-20.
2008: Paula Haiko; Taija Makinen; Salla Keskitalo; Jussi Taipale; Marika J Karkkainen; Megan E Baldwin; Steven A Stacker; Marc G Achen; Kari Alitalo
Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.
Molecular and cellular biology 2008;28(15):4843-50.
2008: Tuomas Tammela; Georgia Zarkada; Elisabet Wallgard; Aino Murtomäki; Steven Suchting; Maria Wirzenius; Marika Waltari; Mats Hellström; Tibor Schomber; Reetta Peltonen; Catarina Freitas; António Duarte; Helena Isoniemi; Pirjo Laakkonen; Gerhard Christofori; Seppo Ylä-Herttuala; Masabumi Shibuya; Bronislaw Pytowski; Anne Eichmann; Christer Betsholtz; Kari Alitalo
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.
Nature 2008;454(7204):656-60.
2008: Caroline A Heckman; Tanja Holopainen; Maria Wirzenius; Salla Keskitalo; Michael Jeltsch; Seppo Ylä-Herttuala; Stephen R Wedge; Juliane M Jürgensmeier; Kari Alitalo
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
Cancer research 2008;68(12):4754-62.
2008: Martin Melcher; Bernd Unger; Uwe Schmidt; Iiro A Rajantie; Kari Alitalo; Wilfried Ellmeier
Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):8048-56.
2008: Tatiana V Petrova; Petri Bono; Wolfgang Holnthoner; Jessica Chesnes; Bronislaw Pytowski; Harri Sihto; Pirjo Laakkonen; Päivi Heikkilä; Heikki Joensuu; Kari Alitalo
VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors.
Cancer cell 2008;13(6):554-6.
2008: Susanna Lauttia (neé Purhonen); Jarmo Palm; Derrick Rossi; Nina Kaskenpää; Iiro Rajantie; Seppo Ylä-Herttuala; Kari Alitalo; Irving L Weissman; Petri Salven
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(18):6620-5.
2008: Tatiana V Petrova; Antti Nykänen; Camilla Norrmén; Konstantin I Ivanov; Leif C Andersson; Caj Haglund; Pauli Puolakkainen; Frank Wempe; Harald von Melchner; Gérard Gradwohl; Sakari Vanharanta; Lauri A Aaltonen; Juha Saharinen; Massimiliano Gentile; Alan Clarke; Jussi Taipale; Guillermo Oliver; Kari Alitalo
Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.
Cancer cell 2008;13(5):407-19.
2008: Françoise Bruyère; Laurence Melen-Lamalle; Silvia Blacher; Guy Roland; Marc Thiry; Lieve Moons; Francis Frankenne; Peter Carmeliet; Kari Alitalo; Claude Libert; Jonathan P Sleeman; Jean-Michel Foidart; Agnès Noël
Modeling lymphangiogenesis in a three-dimensional culture system.
Nature methods 2008;5(5):431-7.
2008: Pipsa Saharinen; Lauri Eklund; Juho J Miettinen; Riikka Wirkkala; Andrey Anisimov; Mark Winderlich; Astrid Nottebaum; Dietmar Vestweber; Urban Deutsch; Gou Young Koh; Bjorn R Olsen; Kari Alitalo
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts.
Nature cell biology 2008;10(5):527-37.
2008: Andrew V Benest; Steven J Harper; Seppo Yla Herttuala; Kari Alitalo; David O Bates
VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis.
Cardiovascular research 2008;78(2):315-23.
2008: Bong-Hyun Jeon; Cholsoon Jang; Jinah Han; KATARU RAGHU; Lianhua Piao; Keehoon Jung; Hye Ji Cha; Reto Schwendener; Kyu Yun Jang; Kwan-Sik Kim; Kari Alitalo; Gou Young Koh
Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer.
Cancer research 2008;68(4):1100-9.
2008: Terhi Karpanen; Kari Alitalo
Molecular biology and pathology of lymphangiogenesis.
Annual review of pathology 2008;3():367-97.
2007: Gaëlle Brideau; Markus Makinen; Harri Elamaa; Hongmin Tu; Gunnar Nilsson; Kari Alitalo; Taina Pihlajaniemi; Ritva Heljasvaara
Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice.
Cancer research 2007;67(24):11528-35.
2007: Seppo Ylä-Herttuala; Kari Alitalo
On the relationship of LDL and VEGFR1: not just a family affair.
EMBO reports 2007;8(12):1127-8.
2007: Tuomas Tammela; Anne Saaristo; Tanja Holopainen; Johannes Lyytikkä; Anna Kotronen; Miia Pitkonen; Usama Abo Ramadan; Seppo Ylä-Herttuala; Tatiana V Petrova; Kari Alitalo
Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation.
Nature medicine 2007;13(12):1458-66.
2007: Ebba Brakenhielm; Jeremy B Burton; Mai Johnson; Nelson Chavarria; Kouki Morizono; Irvin Chen; Kari Alitalo; Lily Wu
Modulating metastasis by a lymphangiogenic switch in prostate cancer.
International journal of cancer. Journal international du cancer 2007;121(10):2153-61.
2007: Sonja Koopal; Johanna H Furuhjelm; Annika Järviluoma; Sari Jäämaa; Pawan Pyakurel; Christel Pussinen; Maria Wirzenius; Peter Biberfeld; Kari Alitalo; Marikki Laiho; Päivi M Ojala
Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.
PLoS pathogens 2007;3(9):1348-60.
2007: Hanna Heloterä; Kari Alitalo
The VEGF family, the inside story.
Cell 2007;130(4):591-2.
2007: Maria Wirzenius; Tuomas Tammela; Marko Uutela; Yulong He; Teresa Odorisio; Giovanna Zambruno; Janice A Nagy; Harold F Dvorak; Seppo Ylä-Herttuala; Masabumi Shibuya; Kari Alitalo
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.
The Journal of experimental medicine 2007;204(6):1431-40.
2007: Surbhi Gupta; Antoine R Ramjaun; Paula Haiko; Yihua Wang; Patricia H Warne; Barbara Nicke; Emma Nye; Gordon Stamp; Kari Alitalo; Julian Downward
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.
Cell 2007;129(5):957-68.
2007: Ralf H Adams; Kari Alitalo
Molecular regulation of angiogenesis and lymphangiogenesis.
Nature reviews. Molecular cell biology 2007;8(6):464-78.
2007: Salla Keskitalo; Tuomas Tammela; Johannes Lyytikka; Terhi Karpanen; Michael Jeltsch; Johanna E Markkanen; Seppo Yla-Herttuala; Kari Alitalo
Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein.
Circulation research 2007;100(10):1460-7.
2007: Tuomas Tammela; Yulong He; Johannes Lyytikkä; Michael Jeltsch; Johanna E Markkanen; Katri Pajusola; Seppo Ylä-Herttuala; Kari Alitalo
Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins.
Circulation research 2007;100(10):1468-75.
2007: Lucie Kopfstein; Tanja Veikkola; Valentin Djonov; Vanessa Baeriswyl; Tibor Schomber; Karin Strittmatter; Steven A Stacker; Marc G Achen; Kari Alitalo; Gerhard Christofori
Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis.
The American journal of pathology 2007;170(4):1348-61.
2007: Olivier Raisky; Antti I Nykänen; Rainer Krebs; Maria Hollmén; Mikko A I Keränen; Jussi M Tikkanen; Roope K Sihvola; Leena Alhonen; Petri Salven; Yan Wu; Daniel J Hicklin; Kari Alitalo; Petri K Koskinen; Karl B Lemström
VEGFR-1 and -2 regulate inflammation, myocardial angiogenesis, and arteriosclerosis in chronically rejecting cardiac allografts.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):819-25.
2007: Bradley K McColl; Karri Paavonen; Tara Karnezis; Nicole C Harris; Natalia Davydova; Julie Rothacker; Edouard C Nice; Kenneth W Harder; Sally Roufail; Margaret L Hibbs; Peter A W Rogers; Kari Alitalo; Steven A Stacker; Marc G Achen
Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(4):1088-98.
2007: Satoshi Hirakawa; Lawrence F Brown; Shohta Kodama; Karri Paavonen; Kari Alitalo; Michael Detmar
VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites.
Blood 2007;109(3):1010-7.
2007: Nikolaus Wick; Pipsa Saharinen; Juha Saharinen; Elisabeth Gurnhofer; Carl Walter STEINER; Ingrid Raab; Dejan Stokic; Pietro Giovanoli; Sabine Buchsbaum; Aurea Burchard; Stefan Thurner; Kari Alitalo; Dontscho Kerjaschki
Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitro.
Physiological genomics 2007;28(2):179-92.
2007: Pirjo Laakkonen; Marika Waltari; Tanja Holopainen; Takashi Takahashi; Bronislaw Pytowski; Philipp Steiner; Daniel J Hicklin; Kris Persaud; James R Tonra; Larry Witte; Kari Alitalo
Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth.
Cancer research 2007;67(2):593-9.
2007: Taija Mäkinen; Kari Alitalo
Lymphangiogenesis in development and disease.
Novartis Foundation symposium 2007;283():87-98; discussion 98-105, 238-41.
2007: Steven A Stacker; Rae H Farnsworth; Tara Karnezis; Ramin Shayan; Darrin P Smith; Karri Paavonen; Natalia Davydova; Carol Caesar; Rachael Inder; Megan E Baldwin; Bradley K McColl; Sally Roufail; Richard A Williams; Richard A Hughes; Kari Alitalo; Marc G Achen
Molecular pathways for lymphangiogenesis and their role in human disease.
Novartis Foundation symposium 2007;281():38-43; discussion 44-53, 208-9.
2006: Raimo Tuuminen; Antti I Nykänen; Mikko A I Keränen; Rainer Krebs; Kari Alitalo; Petri K Koskinen; Karl B Lemström
The effect of platelet-derived growth factor ligands in rat cardiac allograft vasculopathy and fibrosis.
Transplantation proceedings 2006;38(10):3271-3.
2006: Birgit Schaffhauser; Tanja Veikkola; Karin Strittmatter; Helena Antoniadis; Kari Alitalo; Gerhard Christofori
Moderate antiangiogenic activity by local, transgenic expression of endostatin in Rip1Tag2 transgenic mice.
Journal of leukocyte biology 2006;80(4):669-76.
2006: Anne Saaristo; Tuomas Tammela; Anniina Farkkilā; Marika Kärkkäinen; Erkki Suominen; Seppo Yla-Herttuala; Kari Alitalo
Vascular endothelial growth factor-C accelerates diabetic wound healing.
The American journal of pathology 2006;169(3):1080-7.
2006: Yun He; Yan Luo; Shibo Tang; Iiro Rajantie; Petri Salven; Matthias Heil; Rong Zhang; Dianhong Luo; Xianghong Li; Hongbo Chi; Jun Yu; Peter Carmeliet; Wolfgang Schaper; Albert J Sinusas; William C Sessa; Kari Alitalo; Wang Min
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis.
The Journal of clinical investigation 2006;116(9):2344-55.
2006: Yujuan Zheng; Masato Murakami; Hiroyuki Takahashi; Mai Yamauchi; Atsushi Kiba; Sachiko Yamaguchi; Naoyuki Yabana; Kari Alitalo; Masabumi Shibuya
Chimeric VEGF-E(NZ7)/PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(9):2019-26.
2006: Terhi Karpanen; Maria Wirzenius; Taija Mäkinen; Tanja Veikkola; Hidde J Haisma; Marc G Achen; Steven A Stacker; Bronislaw Pytowski; Seppo Ylä-Herttuala; Kari Alitalo
Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.
The American journal of pathology 2006;169(2):708-18.
2006: Joakim Janér; Patrik Lassus; Caj Haglund; Karri Paavonen; Kari Alitalo; Sture Andersson
Pulmonary vascular endothelial growth factor-C in development and lung injury in preterm infants.
American journal of respiratory and critical care medicine 2006;174(3):326-30.
2006: Tine V Karlsen; Marika J Karkkainen; Kari Alitalo; Helge Wiig
Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedema.
The Journal of physiology 2006;574(Pt 2):583-96.
2006: Terhi Kärpänen; Caroline A Heckman; Salla Keskitalo; Michael Jeltsch; Hanna Ollila; Gera Neufeld; Luca Tamagnone; Kari Alitalo
Functional interaction of VEGF-C and VEGF-D with neuropilin receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(9):1462-72.
2006: Antti I Nykänen; Katri Pajusola; Rainer Krebs; Mikko A I Keränen; Olivier Raisky; Petri K Koskinen; Kari Alitalo; Karl B Lemström
Common protective and diverse smooth muscle cell effects of AAV-mediated angiopoietin-1 and -2 expression in rat cardiac allograft vasculopathy.
Circulation research 2006;98(11):1373-80.
2006: Johan Kreuger; Ingrid Nilsson; Dontscho Kerjaschki; Tatiana Petrova; Kari Alitalo; Lena Claesson-Welsh
Early lymph vessel development from embryonic stem cells.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(5):1073-8.
2006: Nicholas P J Brindle; Pipsa Saharinen; Kari Alitalo
Signaling and functions of angiopoietin-1 in vascular protection.
Circulation research 2006;98(8):1014-23.
2006: Michael Jeltsch; Terhi Karpanen; Tomas Strandin; Kukka Aho; Hilkka Lankinen; Kari Alitalo
Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns.
The Journal of biological chemistry 2006;281(17):12187-95.
2006: Minoru Takemoto; Liqun He; Jenny Norlin; Jaakko Patrakka; Zhijie Xiao; Tatiana Petrova; Cecilia Bondjers; Julia Asp; Elisabet Wallgard; Ying Sun; Tore Samuelsson; Petter Mostad; Samuel Lundin; Naoyuki Miura; Yoshikazu Sado; Kari Alitalo; Susan E Quaggin; Karl Tryggvason; Christer Betsholtz
Large-scale identification of genes implicated in kidney glomerulus development and function.
The EMBO journal 2006;25(5):1160-74.
2006: Barbara Le Bras; Maria-José Barallobre; Jihane Homman-Ludiye; Annelii Ny; Sabine Wyns; Tuomas Tammela; Paula Haiko; Marika J Karkkainen; Li Yuan; Marie-Paule Muriel; Elli Chatzopoulou; Christiane Bréant; Bernard Zalc; Peter Carmeliet; Kari Alitalo; Anne Eichmann; Jean-Léon Thomas
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
Nature neuroscience 2006;9(3):340-8.
2006: Tommi Pätilä; Tuija Ikonen; Juha Rutanen; Aapo Ahonen; Jyri Lommi; Kimmo Lappalainen; Leena Anneli Krogerus; Leo Ihlberg; Taina A Partanen; Liisa Lähteenoja; Kari Virtanen; Kari Alitalo; Seppo Ylä-Herttuala; Ari L J Harjula
Vascular endothelial growth factor C-induced collateral formation in a model of myocardial ischemia.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2006;25(2):206-13.
2006: Pia Leppänen; Ivana Kholová; Anssi J Mähönen; Kari J Airenne; Suvi Koota; Hannu Mansukoski; Johanna Närväinen; Maria Wirzenius; Leena Alhonen; Juhani Jänne; Kari Alitalo; Seppo Ylä-Herttuala
Short and long-term effects of hVEGF-A(165) in Cre-activated transgenic mice.
PloS one 2006;1():e13.
2005: Kari Alitalo; Tuomas Tammela; Tatiana V Petrova
Lymphangiogenesis in development and human disease.
Nature 2005;438(7070):946-53.
2005: Himadri Roy; Shalini Bhardwaj; Mohan Babu; Suvi Jauhiainen; Karl-Heinz Herzig; Anna R Bellu; Hidde J Haisma; Peter Carmeliet; Kari Alitalo; Seppo Ylä-Herttuala
Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A.
Human gene therapy 2005;16(12):1422-8.
2005: Ugur Ozerdem; Kari Alitalo; Petri Salven; Andrew Li
Contribution of bone marrow-derived pericyte precursor cells to corneal vasculogenesis.
Investigative ophthalmology & visual science 2005;46(10):3502-6.
2005: Pia Leppänen; Suvi Koota; Ivana Kholová; Jonna K Koponen; Christina Fieber; Ulf Eriksson; Kari Alitalo; Seppo Ylä-Herttuala
Gene transfers of vascular endothelial growth factor-A, vascular endothelial growth factor-B, vascular endothelial growth factor-C, and vascular endothelial growth factor-D have no effects on atherosclerosis in hypercholesterolemic low-density lipoprotein-receptor/apolipoprotein B48-deficient mice.
Circulation 2005;112(9):1347-52.
2005: JianMin Lin; Alshad Lalani; Thomas C Harding; Melissa Gonzalez; Wei-Wei Wu; Bo Luan; Guang Huan Tu; Kathryn Koprivnikar; Melinda VanRoey; Yulong He; Kari Alitalo; Karin Jooss
Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor.
Cancer research 2005;65(15):6901-9.
2005: Tuomas Tammela; Tatiana V Petrova; Kari Alitalo
Molecular lymphangiogenesis: new players.
Trends in cell biology 2005;15(8):434-41.
2005: Katri Pajusola; Jaana Künnapuu; Sanna Vuorikoski; Jarkko Soronen; Helder André; Teresa Pereira; Petra Korpisalo; Seppo Ylä-Herttuala; Lorenz Poellinger; Kari Alitalo
Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(10):1365-7.
2005: Tuomas Tammela; Anne Saaristo; Marja Lohela; Tohru Morisada; Jenny Tornberg; Camilla Norrmén; Yuichi Oike; Katri Pajusola; Gavin Thurston; Toshio Suda; Seppo Yla-Herttuala; Kari Alitalo
Angiopoietin-1 promotes lymphatic sprouting and hyperplasia.
Blood 2005;105(12):4642-8.
2005: Tohru Morisada; Yuichi Oike; Yoshihiro Yamada; Takashi Urano; Masaki Akao; Yoshiaki Kubota; Hiromitsu Maekawa; Yoshishige Kimura; Masako Ohmura; Takeshi Miyamoto; Shiro Nozawa; Gou Young Koh; Kari Alitalo; Toshio Suda
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation.
Blood 2005;105(12):4649-56.
2005: Yulong He; Iiro Rajantie; Katri Pajusola; Michael Jeltsch; Tanja Holopainen; Seppo Yla-Herttuala; Thomas C Harding; Karin Jooss; Takashi Takahashi; Kari Alitalo
Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels.
Cancer research 2005;65(11):4739-46.
2005: Anne Eichmann; Taija Makinen; Kari Alitalo
Neural guidance molecules regulate vascular remodeling and vessel navigation.
Genes & development 2005;19(9):1013-21.
2005: Pipsa Saharinen; Katja Kerkelä; Niklas Ekman; Marie Marron; Nicholas P J Brindle; Gyun Min Lee; Hellmut G Augustin; Gou Young Koh; Kari Alitalo
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2.
The Journal of cell biology 2005;169(2):239-43.
2005: Volkhard A J Kempf; Maria Lebiedziejewski; Kari Alitalo; Joo-Hee Wälzlein; Urs Ehehalt; Jeannette Fiebig; Stephan Huber; Burkhardt Schütt; Christian Sander; Steffen Müller; Guntram A Grassl; Amir S Yazdi; Bernhard R Brehm; Ingo B Autenrieth
Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: evidence for a role of hypoxia-inducible factor-1 in bacterial infections.
Circulation 2005;111(8):1054-62.
2005: Shalini Bhardwaj; Himadri Roy; T Kärpänen; Y He; Y Hi; Suvi Jauhiainen; Marja Hedman; Kari Alitalo; Seppo Ylä-Herttuala
Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries.
Gene therapy 2005;12(5):388-94.
2005: Tuomas Tammela; Berndt Enholm; Kari Alitalo; Kristian J Paavonen
The biology of vascular endothelial growth factors.
Cardiovascular research 2005;65(3):550-63.
2005: Taija Mäkinen; Ralf H Adams; John Bailey; Qiang Lu; Andrew Ziemiecki; Kari Alitalo; Rüdiger Klein; George A Wilkinson
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.
Genes & development 2005;19(3):397-410.
2005: Peter Baluk; Tuomas Tammela; Erin Ator; Natalya Lyubynska; Marc G Achen; Daniel J Hicklin; Michael Jeltsch; Tatiana V Petrova; Bronislaw Pytowski; Steven A Stacker; Seppo Ylä-Herttuala; David G Jackson; Kari Alitalo; Donald M McDonald
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.
The Journal of clinical investigation 2005;115(2):247-57.
2005: Guillermo Oliver; Kari Alitalo
The lymphatic vasculature: recent progress and paradigms.
Annual review of cell and developmental biology 2005;21():457-83.
2005: Sara A Wickström; Kari Alitalo; Jorma Keski-Oja
Endostatin signaling and regulation of endothelial cell-matrix interactions.
Advances in cancer research 2005;94():197-229.
2004: Kari Alitalo; Suresh Mohla; Erkki Ruoslahti
Lymphangiogenesis and cancer: meeting report.
Cancer research 2004;64(24):9225-9.
2004: Ivana Crnic; Karin Strittmatter; Ugo Cavallaro; Lucie Kopfstein; Lotta Jussila; Kari Alitalo; Gerhard Christofori
Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesis.
Cancer research 2004;64(23):8630-8.
2004: Marko Uutela; Maria Wirzenius; Kristian J Paavonen; Iiro Rajantie; Yulong He; Terhi Karpanen; Marja Lohela; Helge Wiig; Petri Salven; Katri Pajusola; Ulf Eriksson; Kari Alitalo
PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.
Blood 2004;104(10):3198-204.
2004: Anne Saaristo; Tuomas Tammela; Jari Timonen; Seppo Yla-Herttuala; Erkki Tukiainen; Sirpa Asko-Seljavaara; Kari Alitalo
Vascular endothelial growth factor-C gene therapy restores lymphatic flow across incision wounds.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(14):1707-9.
2004: Ingrid Nilsson; Charlotte Rolny; Yan Wu; Bronislaw Pytowski; Daniel J Hicklin; Kari Alitalo; Lena Claesson-Welsh; Stefan Wennström
Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(13):1507-15.
2004: Iiro Rajantie; Maritta Ilmonen; Agne Alminaite; Ugur Ozerdem; Kari Alitalo; Petri Salven
Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells.
Blood 2004;104(7):2084-6.
2004: Tatiana V Petrova; Terhi Karpanen; Camilla Norrmén; Russell H Mellor; Tomoki Tamakoshi; David N Finegold; Robert E Ferrell; Dontscho Kerjaschki; Peter Mortimer; Seppo Ylä-Herttuala; Naoyuki Miura; Kari Alitalo
Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis.
Nature medicine 2004;10(9):974-81.
2004: Kristian J Paavonen; Niklas Ekman; Maria Wirzenius; Iiro Rajantie; Matti Poutanen; Kari Alitalo
Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing.
Molecular biology of the cell 2004;15(9):4226-33.
2004: Hiroko Bando; Maren Brokelmann; Masakazu Toi; Kari Alitalo; Jonathan P Sleeman; Bence Sipos; Hermann-Josef Gröne; Herbert A Weich
Immunodetection and quantification of vascular endothelial growth factor receptor-3 in human malignant tumor tissues.
International journal of cancer. Journal international du cancer 2004;111(2):184-91.
2004: Craig Stolen; Gennady G Yegutkin; Riikka Kurkijärvi; Petri Bono; Kari Alitalo; Sirpa Jalkanen
Origins of serum semicarbazide-sensitive amine oxidase.
Circulation research 2004;95(1):50-7.
2004: Hsei-Wei Wang; Matthew W B Trotter; Dimitrios Lagos; Dimitra Bourboulia; Stephen Henderson; Taija Mäkinen; Stephen Elliman; Adrienne M Flanagan; Kari Alitalo; Chris Boshoff
Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.
Nature genetics 2004;36(7):687-93.
2004: Pipsa Saharinen; Tuomas Tammela; Marika J Karkkainen; Kari Alitalo
Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation.
Trends in immunology 2004;25(7):387-95.
2004: Yulong He; Iiro Rajantie; Maritta Ilmonen; Taija Makinen; Marika J Karkkainen; Paula Haiko; Petri Salven; Kari Alitalo
Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis.
Cancer research 2004;64(11):3737-40.
2004: Sara A Wickström; Kari Alitalo; Jorma Keski-Oja
An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells.
The Journal of biological chemistry 2004;279(19):20178-85.
2004: Marcin Gruchała; Shalini Bhardwaj; Katri Pajusola; Himadri Roy; Tuomas T Rissanen; Ilze Kokina; Ivana Kholová; Johanna E Markkanen; Juha Rutanen; Tommi Heikura; Kari Alitalo; Hansruedi Büeler; Seppo Ylä-Herttuala
Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors.
The journal of gene medicine 2004;6(5):545-54.
2004: Renhai Cao; Anna Eriksson; Hajime Kubo; Kari Alitalo; Yihai Cao; Johan Thyberg
Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability.
Circulation research 2004;94(5):664-70.
2004: Olli Leppänen; Juha Rutanen; Mikko O Hiltunen; Tuomas T Rissanen; Mikko Turunen; Tobias Sjöblom; Josef Brüggen; Gudrun Bäckström; Marianne Carlsson; Elisabeth Buchdunger; David Bergqvist; Kari Alitalo; Carl-Henrik Heldin; Arne Ostman; Seppo Ylä-Herttuala
Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits.
Circulation 2004;109(9):1140-6.
2004: Yulong He; Terhi Karpanen; Kari Alitalo
Role of lymphangiogenic factors in tumor metastasis.
Biochimica et biophysica acta 2004;1654(1):3-12.
2004: Rinnat M Porat; Myriam Grunewald; Anat Globerman; Ahuva Itin; Gregory Barshtein; Leena Alhonen; Kari Alitalo; Eli Keshet
Specific induction of tie1 promoter by disturbed flow in atherosclerosis-prone vascular niches and flow-obstructing pathologies.
Circulation research 2004;94(3):394-401.
2004: Herbert A Weich; Hiroko Bando; Maren Brokelmann; Petra Baumann; Masakazu Toi; Bernhard Barleon; Kari Alitalo; Bence Sipos; Jonathan Sleeman
Quantification of vascular endothelial growth factor-C (VEGF-C) by a novel ELISA.
Journal of immunological methods 2004;285(2):145-55.
2004: Elke A Ober; Birgitta Olofsson; Taija Mäkinen; Suk-Won Jin; Wataru Shoji; Gou Young Koh; Kari Alitalo; Didier Y R Stainier
Vegfc is required for vascular development and endoderm morphogenesis in zebrafish.
EMBO reports 2004;5(1):78-84.
2004: Marika J Karkkainen; Paula Haiko; Kirsi Sainio; Juha Partanen; Jussi Taipale; Tatiana V Petrova; Michael Jeltsch; David G Jackson; Marja Talikka; Heikki Rauvala; Christer Betsholtz; Kari Alitalo
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.
Nature immunology 2004;5(1):74-80.
2003: Rong Zhang; Yingqian Xu; Niklas Ekman; Zhenhua Wu; Jiong Wu; Kari Alitalo; Wang Min
Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway.
The Journal of biological chemistry 2003;278(51):51267-76.
2003: Tanja Veikkola; Marja Lohela; Kristian Ikenberg; Taija Mäkinen; Thomas Korff; Anne Saaristo; Tatiana V Petrova; Michael Jeltsch; Hellmut G Augustin; Kari Alitalo
Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2006-13.
2003: Johan Dixelius; Taija Makinen; Maria Wirzenius; Marika J Karkkainen; Christer Wernstedt; Kari Alitalo; Lena Claesson-Welsh
Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.
The Journal of biological chemistry 2003;278(42):40973-9.
2003: Shalini Bhardwaj; Himadri Roy; Marcin Gruchala; Helena Viita; Ivana Kholova; Ilze Kokina; Marc G Achen; Steven A Stacker; Marja Hedman; Kari Alitalo; Seppo Ylä-Herttuala
Angiogenic responses of vascular endothelial growth factors in periadventitial tissue.
Human gene therapy 2003;14(15):1451-62.
2003: Juha Rutanen; Pia Leppänen; Tiina T Tuomisto; Tuomas T Rissanen; Mikko O Hiltunen; Ismo Vajanto; Mari Niemi; Tomi P Häkkinen; Kari Karkola; Steven A Stacker; Marc G Achen; Kari Alitalo; Seppo Ylä-Herttuala
Vascular endothelial growth factor-D expression in human atherosclerotic lesions.
Cardiovascular research 2003;59(4):971-9.
2003: Michael Jeltsch; Tuomas Tammela; Kari Alitalo; Jörg Wilting
Genesis and pathogenesis of lymphatic vessels.
Cell and tissue research 2003;314(1):69-84.
2003: Sara A Wickström; Kari Alitalo; Jorma Keski-Oja
Endostatin associates with lipid rafts and induces reorganization of the actin cytoskeleton via down-regulation of RhoA activity.
The Journal of biological chemistry 2003;278(39):37895-901.
2003: Bradley K McColl; Megan E Baldwin; Sally Roufail; Craig Freeman; Robert L Moritz; Richard J Simpson; Kari Alitalo; Steven A Stacker; Marc G Achen
Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D.
The Journal of experimental medicine 2003;198(6):863-8.
2003: Yama A Abassi; Marko Rehn; Niklas Ekman; Kari Alitalo; Kristiina Vuori
p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration.
The Journal of biological chemistry 2003;278(37):35636-43.
2003: Erika Iivanainen; Lassi Nelimarkka; Varpu Elenius; Satu-Maria Heikkinen; Teemu T Junttila; Laura Sihombing; Maria Sundvall; Jorma A Maatta; Jukka Laine; Seppo Yla-Herttuala; Shigeki Higashiyama; Kari Alitalo; Klaus Elenius
Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(12):1609-21.
2003: Marja Lohela; Anne Saaristo; Tanja Veikkola; Kari Alitalo
Lymphangiogenic growth factors, receptors and therapies.
Thrombosis and haemostasis 2003;90(2):167-84.
2003: Bo Hu; Ping Guo; Quan Fang; Huo-Quan Tao; Degui Wang; Motoo Nagane; Hui-Jein Su Huang; Yuji Gunji; Ryo Nishikawa; Kari Alitalo; Webster K Cavenee; Shi-Yuan Cheng
Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8904-9.
2003: Holger Gerhardt; Matthew Golding; Marcus Fruttiger; Christiana Ruhrberg; Andrea Lundkvist; Alexandra Abramsson; Michael Jeltsch; Christopher Mitchell; Kari Alitalo; David T Shima; Christer Betsholtz
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia.
The Journal of cell biology 2003;161(6):1163-77.
2003: Sara A Wickström; Jorma Keski-Oja; Kari Alitalo
Matrix reloaded to circulation hits the tumor target.
Cancer cell 2003;3(6):513-4.
2003: Seppo Ylä-Herttuala; Kari Alitalo
Gene transfer as a tool to induce therapeutic vascular growth.
Nature medicine 2003;9(6):694-701.
2003: Tuomas T Rissanen; Johanna E Markkanen; Marcin Gruchala; Tommi Heikura; Antti Puranen; Mikko I Kettunen; Ivana Kholová; Risto A Kauppinen; Marc G Achen; Steven A Stacker; Kari Alitalo; Seppo Ylä-Herttuala
VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses.
Circulation research 2003;92(10):1098-106.
2003: Pipsa Saharinen; Kari Alitalo
Double target for tumor mass destruction.
The Journal of clinical investigation 2003;111(9):1277-80.
2003: Jean-Christophe Tille; Xueyan Wang; Kenneth E Lipson; Gerald McMahon; Napoleone Ferrara; Zhenping Zhu; Daniel J Hicklin; Jonathan P Sleeman; Ulf Eriksson; Kari Alitalo; Michael S Pepper
Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro.
Experimental cell research 2003;285(2):286-98.
2003: Merja I Auvinen; Kristiina Järvinen; Anneli Hotti; Juha Okkeri; Jens Laitinen; Olli A Jänne; Philip Coffino; Mathias Bergman; Leif C Andersson; Kari Alitalo; Erkki Hölttä
Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc.
The international journal of biochemistry & cell biology 2003;35(4):496-521.
2003: Antti I Nykänen; Rainer Krebs; Anne Saaristo; Päivi Turunen; Kari Alitalo; Seppo Ylä-Herttuala; Petri K Koskinen; Karl B Lemström
Angiopoietin-1 protects against the development of cardiac allograft arteriosclerosis.
Circulation 2003;107(9):1308-14.
2003: Hajime Kubo; Kari Alitalo
The bloody fate of endothelial stem cells.
Genes & development 2003;17(3):322-9.
2003: Juha Klefström; Kari Alitalo
[Lentiviruses to use].
Duodecim; lääketieteellinen aikakauskirja 2003;119(20):1917-9.
2003: Petri Salven; Satu Mustjoki; Riitta Alitalo; Kari Alitalo; Shahin Rafii
VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells.
Blood 2003;101(1):168-72.
2002: Anne Saaristo; Marika J Karkkainen; Kari Alitalo
Insights into the molecular pathogenesis and targeted treatment of lymphedema.
Annals of the New York Academy of Sciences 2002;979():94-110.
2002: Andrzej Szuba; Mihaela Skobe; Marika J Karkkainen; William S Shin; David P Beynet; Ned B Rockson; Noma Dakhil; Stan Spilman; Michael L Goris; Harry W Strauss; Thomas Quertermous; Kari Alitalo; Stanley G Rockson
Therapeutic lymphangiogenesis with human recombinant VEGF-C.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):1985-7.
2002: Riyaz N H Shah; J Claire Ibbitt; Kari Alitalo; Helen C Hurst
FGFR4 overexpression in pancreatic cancer is mediated by an intronic enhancer activated by HNF1alpha.
Oncogene 2002;21(54):8251-61.
2002: Kristina Iljin; Tatiana V Petrova; Tanja Veikkola; Vijay Kumar; Matti Poutanen; Kari Alitalo
A fluorescent Tie1 reporter allows monitoring of vascular development and endothelial cell isolation from transgenic mouse embryos.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(13):1764-74.
2002: Li Yuan; Delphine Moyon; Luc Pardanaud; Christiane Bréant; Marika J Karkkainen; Kari Alitalo; Anne Eichmann
Abnormal lymphatic vessel development in neuropilin 2 mutant mice.
Development (Cambridge, England) 2002;129(20):4797-806.
2002: Sara A Wickström; Kari Alitalo; Jorma Keski-Oja
Endostatin associates with integrin alpha5beta1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells.
Cancer research 2002;62(19):5580-9.
2002: Anne Saaristo; Tanja Veikkola; Tuomas Tammela; Berndt Enholm; Marika J Karkkainen; Katri Pajusola; Hansruedi Bueler; Seppo Ylä-Herttuala; Kari Alitalo
Lymphangiogenic gene therapy with minimal blood vascular side effects.
The Journal of experimental medicine 2002;196(6):719-30.
2002: Tatiana V Petrova; Taija Mäkinen; Tomi Mäkelä; Janna Saarela; Ismo Virtanen; Robert E Ferrell; David N Finegold; Dontscho Kerjaschki; Seppo Ylä-Herttuala; Kari Alitalo
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.
The EMBO journal 2002;21(17):4593-9.
2002: Tanja Veikkola; Kari Alitalo
Dual role of Ang2 in postnatal angiogenesis and lymphangiogenesis.
Developmental cell 2002;3(3):302-4.
2002: Sebastian F Schoppmann; Peter Birner; Johannes Stöckl; Romana Kalt; Robert Ullrich; Carola Caucig; Ernst Kriehuber; Katalin Nagy; Kari Alitalo; Dontscho Kerjaschki
Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis.
The American journal of pathology 2002;161(3):947-56.
2002: Steven A Stacker; Marc G Achen; Lotta Jussila; Megan E Baldwin; Kari Alitalo
Lymphangiogenesis and cancer metastasis.
Nature reviews. Cancer 2002;2(8):573-83.
2002: Ulf Eriksson; Kari Alitalo
VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies.
Nature medicine 2002;8(8):775-7.
2002: Jörg Wilting; Maria Papoutsi; Bodo Christ; Kypros H Nicolaides; Constantin S von Kaisenberg; Joerg Borges; G Björn Stark; Kari Alitalo; Stanislav I Tomarev; Charlotte Niemeyer; Jochen Rössler
The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(10):1271-3.
2002: Claus Cursiefen; Ursula Schlötzer-Schrehardt; Michael Küchle; Lydia Sorokin; Silvana Breiteneder-Geleff; Kari Alitalo; David Jackson
Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin.
Investigative ophthalmology & visual science 2002;43(7):2127-35.
2002: Lotta Jussila; Kari Alitalo
Vascular growth factors and lymphangiogenesis.
Physiological reviews 2002;82(3):673-700.
2002: Anne Saaristo; Tanja Veikkola; Berndt Enholm; Maija Hytönen; Johanna Arola; Katri Pajusola; Païvi Turunen; Michael Jeltsch; Marika J Karkkainen; Dontscho Kerjaschki; Hansruedi Bueler; Seppo Ylä-Herttuala; Kari Alitalo
Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):1041-9.
2002: Hajime Kubo; Renhai Cao; Ebba Brakenhielm; Taija Mäkinen; Yihai Cao; Kari Alitalo
Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8868-73.
2002: Kari Alitalo
Growth factors controlling angiogenesis and lymphangiogenesis.
Ugeskrift for laeger 2002;164(24):3170-2.
2002: Yulong He; Ken-Ichi Kozaki; Terhi Karpanen; Katsumi Koshikawa; Seppo Yla-Herttuala; Takashi Takahashi; Kari Alitalo
Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling.
Journal of the National Cancer Institute 2002;94(11):819-25.
2002: Marc G Achen; Richard A Williams; Megan E Baldwin; Patricia Lai; Sally Roufail; Kari Alitalo; Steven A Stacker
The angiogenic and lymphangiogenic factor vascular endothelial growth factor-D exhibits a paracrine mode of action in cancer.
Growth factors (Chur, Switzerland) 2002;20(2):99-107.
2002: Karl B Lemström; Rainer Krebs; Antti I Nykänen; Jussi M Tikkanen; Roope K Sihvola; Eva M Aaltola; Pekka Häyry; Jeanette Wood; Kari Alitalo; Seppo Ylä-Herttuala; Petri K Koskinen
Vascular endothelial growth factor enhances cardiac allograft arteriosclerosis.
Circulation 2002;105(21):2524-30.
2002: Sandrine Marchetti; Clotilde Gimond; Kristiina Iljin; Christine Bourcier; Kari Alitalo; Jacques Pouysségur; Gilles Pagès
Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo.
Journal of cell science 2002;115(Pt 10):2075-85.
2002: Mirjami M Mattila; Johanna K Ruohola; Terhi Karpanen; David G Jackson; Kari Alitalo; Pirkko L Härkönen
VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors.
International journal of cancer. Journal international du cancer 2002;98(6):946-51.
2002: Kari Alitalo; Peter Carmeliet
Molecular mechanisms of lymphangiogenesis in health and disease.
Cancer cell 2002;1(3):219-27.
2002: Yan Zhou; Michael McMaster; Kirstin Woo; Mary Janatpour; Jean Perry; Terhi Karpanen; Kari Alitalo; Caroline Damsky; Susan J Fisher
Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome.
The American journal of pathology 2002;160(4):1405-23.
2002: Sergio Dias; Margaret Choy; Kari Alitalo; Shahin Rafii
Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy.
Blood 2002;99(6):2179-84.
2002: Antonella N Witmer; Harriet G Blaauwgeers; Herbert A Weich; Kari Alitalo; Gijs F J M Vrensen; Reinier O Schlingemann
Altered expression patterns of VEGF receptors in human diabetic retina and in experimental VEGF-induced retinopathy in monkey.
Investigative ophthalmology & visual science 2002;43(3):849-57.
2002: Marika J Karkkainen; Kari Alitalo
Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis.
Seminars in cell & developmental biology 2002;13(1):9-18.
2002: Taija Mäkinen; Kari Alitalo
Molecular mechanisms of lymphangiogenesis.
Cold Spring Harbor symposia on quantitative biology 2002;67():189-96.
2002: Kristian J Paavonen; Jami Mandelin; Taina A Partanen; Lotta Jussila; Tian-Fang Li; Ari Ristimaki; Kari Alitalo; Yrjö T Konttinen
Vascular endothelial growth factors C and D and their VEGFR-2 and 3 receptors in blood and lymphatic vessels in healthy and arthritic synovium.
The Journal of rheumatology 2002;29(1):39-45.
2002: Marika J Karkkainen; Taija Mäkinen; Kari Alitalo
Lymphatic endothelium: a new frontier of metastasis research.
Nature cell biology 2002;4(1):E2-5.
2001: Megan E Baldwin; Sally Roufail; Michael M Halford; Kari Alitalo; Steven A Stacker; Marc G Achen
Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis.
The Journal of biological chemistry 2001;276(47):44307-14.
2001: Tapio I Heino; T Kärpänen; Gudrun Wahlström; Mari-Anne Pulkkinen; Ulf Eriksson; Kari Alitalo; Christophe Roos
The Drosophila VEGF receptor homolog is expressed in hemocytes.
Mechanisms of development 2001;109(1):69-77.
2001: Marika J Karkkainen; Anne Saaristo; Lotta Jussila; K A Karila; Elizabeth Lawrence; Katri Pajusola; Hansruedi Bueler; Anne Eichmann; Raili Kauppinen; Mikko I Kettunen; Seppo Yla-Herttuala; David N Finegold; Robert E Ferrell; Kari Alitalo
A model for gene therapy of human hereditary lymphedema.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12677-82.
2001: Terhi Karpanen; Kari Alitalo
Lymphatic vessels as targets of tumor therapy?
The Journal of experimental medicine 2001;194(6):F37-42.
2001: Taija Mäkinen; Tanja Veikkola; Satu Mustjoki; Terhi Karpanen; Bruno Catimel; Edouard C Nice; L Wise; Andrew A Mercer; H Kowalski; Dontscho Kerjaschki; Steven A Stacker; Marc G Achen; Kari Alitalo
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3.
The EMBO journal 2001;20(17):4762-73.
2001: Volkhard A J Kempf; B Volkmann; Martin Schaller; Christian Sander; Kari Alitalo; Tanja Riess; Ingo B Autenrieth
Evidence of a leading role for VEGF in Bartonella henselae-induced endothelial cell proliferations.
Cellular microbiology 2001;3(9):623-32.
2001: Mihaela Skobe; Leena M Hamberg; Thomas Hawighorst; M Schirner; G L Wolf; Kari Alitalo; Michael Detmar
Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma.
The American journal of pathology 2001;159(3):893-903.
2001: Sara A Wickström; Tanja Veikkola; Marko Rehn; Taina Pihlajaniemi; Kari Alitalo; Jorma Keski-Oja
Endostatin-induced modulation of plasminogen activation with concomitant loss of focal adhesions and actin stress fibers in cultured human endothelial cells.
Cancer research 2001;61(17):6511-6.
2001: Antti Ylikorkala; Derrick J Rossi; Nina Korsisaari; Keijo Luukko; Kari Alitalo; Mark Henkemeyer; Tomi Mäkelä
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice.
Science (New York, N.Y.) 2001;293(5533):1323-6.
2001: Karin Aase; G von Euler; Xuri Li; Annica Pontén; P Thorén; R Cao; Y Cao; B Olofsson; Samuel Gebre-Medhin; Milos Pekny; Kari Alitalo; Christer Betsholtz; Ulf Eriksson
Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect.
Circulation 2001;104(3):358-64.
2001: Iiro Rajantie; Niklas Ekman; Kristina Iljin; Elena Arighi; Y Gunji; Juha-Pekka Kaukonen; Aarno Palotie; M Dewerchin; Peter Carmeliet; Kari Alitalo
Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium.
Molecular and cellular biology 2001;21(14):4647-55.
2001: Megan E Baldwin; Bruno Catimel; Edouard C Nice; Sally Roufail; Nathan E Hall; Kaye L Stenvers; M J Karkkainen; Kari Alitalo; Steven A Stacker; Marc G Achen
The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man.
The Journal of biological chemistry 2001;276(22):19166-71.
2001: Marko Uutela; J Laurén; E Bergsten; Xuri Li; N Horelli-Kuitunen; Ulf Eriksson; Kari Alitalo
Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFD genes.
Circulation 2001;103(18):2242-7.
2001: E Bergsten; Marko Uutela; Xuri Li; Kristian Pietras; Arne Ostman; Carl-Henrik Heldin; Kari Alitalo; Ulf Eriksson
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.
Nature cell biology 2001;3(5):512-6.
2001: Kristina Iljin; Marika J Karkkainen; Elizabeth Lawrence; Mark A Kimak; Marko Uutela; Jussi Taipale; Katri Pajusola; L Alhonen; Maria Halmekytö; David N Finegold; Robert E Ferrell; Kari Alitalo
VEGFR3 gene structure, regulatory region, and sequence polymorphisms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(6):1028-36.
2001: Nina Jones; K Iljin; Daniel J Dumont; Kari Alitalo
Tie receptors: new modulators of angiogenic and lymphangiogenic responses.
Nature reviews. Molecular cell biology 2001;2(4):257-67.
2001: Berndt Enholm; Terhi Karpanen; Michael Jeltsch; Hajime Kubo; F Stenback; Remko Prevo; David G Jackson; Seppo Yla-Herttuala; Kari Alitalo
Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin.
Circulation research 2001;88(6):623-9.
2001: Tanja Veikkola; Lotta Jussila; Taija Makinen; Terhi Karpanen; Michael Jeltsch; Tatiana V Petrova; Hajime Kubo; G Thurston; Donald M McDonald; Marc G Achen; Steven A Stacker; Kari Alitalo
Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice.
The EMBO journal 2001;20(6):1223-31.
2001: Terhi Karpanen; Mikala Egeblad; Marika J Karkkainen; Hajime Kubo; Seppo Ylä-Herttuala; Marja Jäättelä; Kari Alitalo
Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth.
Cancer research 2001;61(5):1786-90.
2001: Krystyna Teichert-Kuliszewska; P C Maisonpierre; Nina Jones; Andrew I M Campbell; Zubin Master; Michelle P Bendeck; Kari Alitalo; Daniel J Dumont; G D Yancopoulos; Duncan J Stewart
Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2.
Cardiovascular research 2001;49(3):659-70.
2001: Stefano J Mandriota; Lotta Jussila; Michael Jeltsch; A Compagni; Danielle Baetens; Remko Prevo; Suneale Banerji; J Huarte; Roberto Montesano; David G Jackson; Lelio Orci; Kari Alitalo; Gerhard Christofori; Michael S Pepper
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis.
The EMBO journal 2001;20(4):672-82.
2001: Taija Mäkinen; Lotta Jussila; Tanja Veikkola; Terhi Karpanen; Mikko I Kettunen; Kalevi Juhani Pulkkanen; Raili Kauppinen; David G Jackson; Hajime Kubo; S Nishikawa; Seppo Ylä-Herttuala; Kari Alitalo
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
Nature medicine 2001;7(2):199-205.
2001: Mihaela Skobe; Thomas Hawighorst; David G Jackson; Remko Prevo; Lauren Janes; Paula Velasco; Lucia Riccardi; Kari Alitalo; Kevin P Claffey; Michael Detmar
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis.
Nature medicine 2001;7(2):192-8.
2001: Marko Rehn; Tanja Veikkola; E Kukk-Valdre; H Nakamura; M Ilmonen; Christian R Lombardo; Taina Pihlajaniemi; Kari Alitalo; Kristiina Vuori
Interaction of endostatin with integrins implicated in angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1024-9.
2001: PIETER KOOLWIJK; E Peters; Bea van der Vecht; Carsten Hornig; Herbert A Weich; Kari Alitalo; D J Hicklin; Y Wu; L Witte; Victor W M van Hinsbergh
Involvement of VEGFR-2 (kdr/flk-1) but not VEGFR-1 (flt-1) in VEGF-A and VEGF-C-induced tube formation by human microvascular endothelial cells in fibrin matrices in vitro.
Angiogenesis 2001;4(1):53-60.
2001: Marika J Karkkainen; Lotta Jussila; Robert E Ferrell; David N Finegold; Kari Alitalo
Molecular regulation of lymphangiogenesis and targets for tissue oedema.
Trends in molecular medicine 2001;7(1):18-22.
2000: Anne Saaristo; Terhi Karpanen; Kari Alitalo
Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis.
Oncogene 2000;19(53):6122-9.
2000: Koichi Hamada; Yuichi Oike; Nobuyuki Takakura; Yasuhiro Ito; Lotta Jussila; Daniel J Dumont; Kari Alitalo; Toshio Suda
VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis.
Blood 2000;96(12):3793-800.
2000: Mikko O Hiltunen; M Laitinen; Mikko Turunen; Michael Jeltsch; Juha Hartikainen; Tuomas T Rissanen; Jari A Laukkanen; Mari Niemi; Maija Kossila; Tomi P Häkkinen; Antti Kivelä; Berndt Enholm; Hannu Mansukoski; Anna-Mari Turunen; Kari Alitalo; Seppo Ylä-Herttuala
Intravascular adenovirus-mediated VEGF-C gene transfer reduces neointima formation in balloon-denuded rabbit aorta.
Circulation 2000;102(18):2262-8.
2000: Taina A Partanen; Johanna Arola; Anne Saaristo; Lotta Jussila; Ari Ora; Markku Miettinen; Steven A Stacker; Marc G Achen; Kari Alitalo
VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(13):2087-96.
2000: Jörg Wilting; M Schneider; M Papoutski; Kari Alitalo; Bodo Christ
An avian model for studies of embryonic lymphangiogenesis.
Lymphology 2000;33(3):81-94.
2000: Niklas Ekman; Elena Arighi; Iiro Rajantie; Pipsa Saharinen; Ari Ristimäki; Olli Silvennoinen; Kari Alitalo
The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner.
Oncogene 2000;19(36):4151-8.
2000: A J Leu; David A Berk; A Lymboussaki; Kari Alitalo; Rakesh K Jain
Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.
Cancer research 2000;60(16):4324-7.
2000: Anne Saaristo; Taina A Partanen; Johanna Arola; Lotta Jussila; Maija Hytönen; Antti A Mäkitie; S Vento; A Kaipainen; Henrik Malmberg; Kari Alitalo
Vascular endothelial growth factor-C and its receptor VEGFR-3 in the nasal mucosa and in nasopharyngeal tumors.
The American journal of pathology 2000;157(1):7-14.
2000: Marika J Karkkainen; Robert E Ferrell; Elizabeth Lawrence; Mark A Kimak; Kara L Levinson; M A McTigue; Kari Alitalo; David N Finegold
Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema.
Nature genetics 2000;25(2):153-9.
2000: Xuri Li; Annica Pontén; Karin Aase; Linda Karlsson; Alexandra Abramsson; Marko Uutela; Gudrun Bäckström; Mats Hellström; Hans Boström; Hong Li; P Soriano; Christer Betsholtz; Carl-Henrik Heldin; Kari Alitalo; Arne Ostman; Ulf Eriksson
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
Nature cell biology 2000;2(5):302-9.
2000: Kristian J Paavonen; Pauli Puolakkainen; Lotta Jussila; Tiina Jahkola; Kari Alitalo
Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing.
The American journal of pathology 2000;156(5):1499-504.
2000: Marc G Achen; Sally Roufail; Teresa Domagala; Bruno Catimel; Edouard C Nice; DM Geleick; Roger Murphy; Andrew M Scott; Carol Caesar; Taija Makinen; Kari Alitalo; Steven A Stacker
Monoclonal antibodies to vascular endothelial growth factor-D block its interactions with both VEGF receptor-2 and VEGF receptor-3.
European journal of biochemistry / FEBS 2000;267(9):2505-15.
2000: B B Loo; K K Darwish; S S Vainikka; J J Saarikettu; P P Vihko; J J Hermonen; A A Goldman; Kari Alitalo; Markku Jalkanen
Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4.
The international journal of biochemistry & cell biology 2000;32(5):489-97.
2000: Piia Vuorela; Satu Helske; Carsten Hornig; Kari Alitalo; Herbert A Weich; Erja Halmesmäki
Amniotic fluid--soluble vascular endothelial growth factor receptor-1 in preeclampsia.
Obstetrics and gynecology 2000;95(3):353-7.
2000: Anne Eichmann; Li Yuan; Christiane Bréant; Kari Alitalo; P J Koskinen
Developmental expression of pim kinases suggests functions also outside of the hematopoietic system.
Oncogene 2000;19(9):1215-24.
2000: Tanja Veikkola; Marika J Karkkainen; L Claesson-Welsh; Kari Alitalo
Regulation of angiogenesis via vascular endothelial growth factor receptors.
Cancer research 2000;60(2):203-12.
2000: A Lymboussaki; Marc G Achen; Steven A Stacker; Kari Alitalo
Growth factors regulating lymphatic vessels.
Current topics in microbiology and immunology 2000;251():75-82.
1999: Mihaela Skobe; Lawrence F Brown; K Tognazzi; Ramesh K Ganju; Bruce J Dezube; Kari Alitalo; Michael Detmar
Vascular endothelial growth factor-C (VEGF-C) and its receptors KDR and flt-4 are expressed in AIDS-associated Kaposi's sarcoma.
The Journal of investigative dermatology 1999;113(6):1047-53.
1999: Taina A Partanen; Kari Alitalo; Markku Miettinen
Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors.
Cancer 1999;86(11):2406-12.
1999: A Lymboussaki; B Olofsson; Ulf Eriksson; Kari Alitalo
Vascular endothelial growth factor (VEGF) and VEGF-C show overlapping binding sites in embryonic endothelia and distinct sites in differentiated adult endothelia.
Circulation research 1999;85(11):992-9.
1999: Tatiana V Petrova; Taija Makinen; Kari Alitalo
Signaling via vascular endothelial growth factor receptors.
Experimental cell research 1999;253(1):117-30.
1999: Steven A Stacker; Kaye L Stenvers; Carol Caesar; A Vitali; Teresa Domagala; Edouard C Nice; Sally Roufail; Richard J Simpson; Robert L Moritz; Terhi Karpanen; Kari Alitalo; Marc G Achen
Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers.
The Journal of biological chemistry 1999;274(45):32127-36.
1999: Nina Jones; Zubin Master; Jamie Jones; Denis Bouchard; Y Gunji; H Sasaki; R Daly; Kari Alitalo; Daniel J Dumont
Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
The Journal of biological chemistry 1999;274(43):30896-905.
1999: Taina A Partanen; Taija Makinen; Johanna Arola; T Suda; HA Weich; Kari Alitalo
Endothelial growth factor receptors in human fetal heart.
Circulation 1999;100(6):583-6.
1999: Harriet G Blaauwgeers; GM Holtkamp; H Rutten; Antonella N Witmer; PIETER KOOLWIJK; T A Partanen; Kari Alitalo; Marielle E Kroon; Aize Kijlstra; Victor W M van Hinsbergh; Reinier O Schlingemann
Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation.
The American journal of pathology 1999;155(2):421-8.
1999: Taija Makinen; B Olofsson; Terhi Karpanen; U Hellman; Shay Soker; Michael Klagsbrun; Ulf Eriksson; Kari Alitalo
Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1.
The Journal of biological chemistry 1999;274(30):21217-22.
1999: Tanja Veikkola; Kari Alitalo
VEGFs, receptors and angiogenesis.
Seminars in cancer biology 1999;9(3):211-20.
1999: Karin Aase; A Lymboussaki; A Kaipainen; B Olofsson; Kari Alitalo; Ulf Eriksson
Localization of VEGF-B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature.
Developmental dynamics : an official publication of the American Association of Anatomists 1999;215(1):12-25.
1999: R Valtola; Petri Salven; Päivi Heikkilä; Jussi Taipale; Heikki Joensuu; Marko Rehn; Taina Pihlajaniemi; HA Weich; R deWaal; Kari Alitalo
VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer.
The American journal of pathology 1999;154(5):1381-90.
1999: P Vuorela-Vepsäläinen; Henrik Alfthan; Arto Orpana; Kari Alitalo; Ulf-Hakan Stenman; Erja Halmesmäki
Vascular endothelial growth factor is bound in amniotic fluid and maternal serum.
Human reproduction (Oxford, England) 1999;14(5):1346-51.
1999: Juha Klefstrom; P E Kovanen; K Somersalo; Anne-Odile Hueber; T Littlewood; Gerard I Evan; A H Greenberg; Eero Saksela; Tuomo Timonen; Kari Alitalo
c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors.
Oncogene 1999;18(13):2181-8.
1999: Johanna K Ruohola; Eeva M Valve; M J Karkkainen; V Joukov; Kari Alitalo; Pirkko L Härkönen
Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells.
Molecular and cellular endocrinology 1999;149(1-2):29-40.
1999: Lyn M Wise; Tanja Veikkola; Andrew A Mercer; Loreen J Savory; Stephen B Fleming; Carol Caesar; A Vitali; Taija Makinen; Kari Alitalo; Steven A Stacker
Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3071-6.
1999: Wolfgang Weninger; T A Partanen; Silvana Breiteneder-Geleff; C Mayer; H Kowalski; Michael Mildner; Johannes Pammer; M Stürzl; Dontscho Kerjaschki; Kari Alitalo; Erwin Tschachler
Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells.
Laboratory investigation; a journal of technical methods and pathology 1999;79(2):243-51.
1999: Silvana Breiteneder-Geleff; Afschin Soleiman; H Kowalski; Reinhard Horvat; Gabriele Amann; Ernst Kriehuber; K Diem; Wolfgang Weninger; Erwin Tschachler; Kari Alitalo; Dontscho Kerjaschki
Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium.
The American journal of pathology 1999;154(2):385-94.
1999: Kristina Iljin; Antoinise Dube; S Kontusaari; J Korhonen; I Lahtinen; Peter Oettgen; Kari Alitalo
Role of ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(2):377-86.
1999: EI Korpelainen; Merja Kärkkäinen; Y Gunji; M Vikkula; Kari Alitalo
Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response.
Oncogene 1999;18(1):1-8.
1999: Jussi Taipale; Taija Makinen; Elena Arighi; E Kukk; Marika J Karkkainen; Kari Alitalo
Vascular endothelial growth factor receptor-3.
Current topics in microbiology and immunology 1999;237():85-96.
1999: U Eriksson; Kari Alitalo
Structure, expression and receptor-binding properties of novel vascular endothelial growth factors.
Current topics in microbiology and immunology 1999;237():41-57.
1998: EI Korpelainen; Marika J Karkkainen; A Tenhunen; Merja Lakso; Heikki Rauvala; Matti Vierula; Martti Parvinen; Kari Alitalo
Overexpression of VEGF in testis and epididymis causes infertility in transgenic mice: evidence for nonendothelial targets for VEGF.
The Journal of cell biology 1998;143(6):1705-12.
1998: Michael S Pepper; Stefano J Mandriota; Michael Jeltsch; V Kumar; Kari Alitalo
Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity.
Journal of cellular physiology 1998;177(3):439-52.
1998: Juha Laurén; Y Gunji; Kari Alitalo
Is angiopoietin-2 necessary for the initiation of tumor angiogenesis?
The American journal of pathology 1998;153(5):1333-9.
1998: Daniel J Dumont; Lotta Jussila; Jussi Taipale; A Lymboussaki; T Mustonen; Katri Pajusola; M Breitman; Kari Alitalo
Cardiovascular failure in mouse embryos deficient in VEGF receptor-3.
Science (New York, N.Y.) 1998;282(5390):946-9.
1998: Berndt Enholm; Lotta Jussila; Marika J Karkkainen; Kari Alitalo
Vascular endothelial growth factor-C: a growth factor for lymphatic and blood vascular endothelial cells.
Trends in cardiovascular medicine 1998;8(7):292-7.
1998: B Olofsson; EI Korpelainen; Michael S Pepper; Stefano J Mandriota; Karin Aase; V Kumar; Y Gunji; Michael Jeltsch; M Shibuya; Kari Alitalo; Ulf Eriksson
Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11709-14.
1998: A Lymboussaki; Taina A Partanen; B Olofsson; Judith Thomas-Crusells; C D Fletcher; R M de Waal; A Kaipainen; Kari Alitalo
Expression of the vascular endothelial growth factor C receptor VEGFR-3 in lymphatic endothelium of the skin and in vascular tumors.
The American journal of pathology 1998;153(2):395-403.
1998: Piia Vuorela; M T Matikainen; Pentti Kuusela; Olavi Ylikorkala; Kari Alitalo; Erja Halmesmäki
Endothelial tie receptor antigen in maternal and cord blood of healthy and preeclamptic subjects.
Obstetrics and gynecology 1998;92(2):179-83.
1998: Ulla Wartiovaara; Petri Salven; H Mikkola; Riitta Lassila; Juha-Pekka Kaukonen; V Joukov; Arto Orpana; Ari Ristimäki; Markku Heikinheimo; Heikki Joensuu; Kari Alitalo; Aarno Palotie
Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation.
Thrombosis and haemostasis 1998;80(1):171-5.
1998: Petri Salven; A Lymboussaki; Päivi Heikkilä; H Jääskela-Saari; B Enholm; Karin Aase; G von Euler; Ulf Eriksson; Kari Alitalo; Heikki Joensuu
Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors.
The American journal of pathology 1998;153(1):103-8.
1998: Lotta Jussila; R Valtola; Taina A Partanen; Petri Salven; Päivi Heikkilä; M T Matikainen; Risto Renkonen; A Kaipainen; Michael Detmar; E Tschachler; Riitta Alitalo; Kari Alitalo
Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3.
Cancer research 1998;58(8):1599-604.
1998: Ari Ristimäki; Kirsi Narko; Berndt Enholm; V Joukov; Kari Alitalo
Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C.
The Journal of biological chemistry 1998;273(14):8413-8.
1998: EI Korpelainen; Kari Alitalo
Signaling angiogenesis and lymphangiogenesis.
Current opinion in cell biology 1998;10(2):159-64.
1998: V Joukov; V Kumar; Timo Sorsa; Elena Arighi; HA Weich; Olli Saksela; Kari Alitalo
A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities.
The Journal of biological chemistry 1998;273(12):6599-602.
1998: Vuokko L Kinnula; Henrikka Aito; J Klefstrom; Kari Alitalo; Kari O Raivio
Similarities between TNF and exogenous oxidants on the cytotoxic response of c-Myc-expressing fibroblasts in vitro.
Cancer letters 1998;125(1-2):191-8.
1998: Anne Eichmann; Catherine Corbel; Thierry Jaffredo; Christiane Bréant; V Joukov; V Kumar; Kari Alitalo; Nicole M Le Douarin
Avian VEGF-C: cloning, embryonic expression pattern and stimulation of the differentiation of VEGFR2-expressing endothelial cell precursors.
Development (Cambridge, England) 1998;125(4):743-52.
1998: Marc G Achen; Michael Jeltsch; E Kukk; Taija Mäkinen; A Vitali; Andrew Wilks; Kari Alitalo; Steven A Stacker
Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4).
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):548-53.
1998: Lotta Jussila; Kari Alitalo; A Kaipainen
[The biology of lymphatic vessels - new findings ].
Duodecim; lääketieteellinen aikakauskirja 1998;114(4):343-8.
1997: Juha Klefstrom; Elena Arighi; T Littlewood; Marja Jäättelä; Eero Saksela; Gerard I Evan; Kari Alitalo
Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation.
The EMBO journal 1997;16(24):7382-92.
1997: Pipsa Saharinen; Niklas Ekman; K Sarvas; P Parker; Kari Alitalo; Olli Silvennoinen
The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta.
Blood 1997;90(11):4341-53.
1997: V Joukov; A Kaipainen; Michael Jeltsch; Katri Pajusola; B Olofsson; V Kumar; Ulf Eriksson; Kari Alitalo
Vascular endothelial growth factors VEGF-B and VEGF-C.
Journal of cellular physiology 1997;173(2):211-5.
1997: D Chilov; E Kukk; Suvi Taira; Michael Jeltsch; Juha-Pekka Kaukonen; Aarno Palotie; V Joukov; Kari Alitalo
Genomic organization of human and mouse genes for vascular endothelial growth factor C.
The Journal of biological chemistry 1997;272(40):25176-83.
1997: Niklas Ekman; A Lymboussaki; I Västrik; K Sarvas; A Kaipainen; Kari Alitalo
Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries.
Circulation 1997;96(6):1729-32.
1997: S J Oh; Michael Jeltsch; Ralf Birkenhäger; J E McCarthy; H A Weich; Bodo Christ; Kari Alitalo; Jörg Wilting
VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane.
Developmental biology 1997;188(1):96-109.
1997: Outi Monni; Heikki Joensuu; Kaarle Franssila; Juha Klefstrom; Kari Alitalo; Sakari Knuutila
BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma.
Blood 1997;90(3):1168-74.
1997: V Joukov; Timo Sorsa; V Kumar; Michael Jeltsch; L Claesson-Welsh; Y Cao; Olli Saksela; Nisse Kalkkinen; Kari Alitalo
Proteolytic processing regulates receptor specificity and activity of VEGF-C.
The EMBO journal 1997;16(13):3898-911.
1997: E Kukk; Ulla Wartiovaara; Y Gunji; Juha-Pekka Kaukonen; H J Bühring; I Rappold; M T Matikainen; P Vihko; J Partanen; Aarno Palotie; Kari Alitalo; Riitta Alitalo
Analysis of Tie receptor tyrosine kinase in haemopoietic progenitor and leukaemia cells.
British journal of haematology 1997;98(1):195-203.
1997: I Rappold; BL Ziegler; I Köhler; Sylvie Marchetto; O Rosnet; Daniel Birnbaum; Paul J Simmons; Andrew C W Zannettino; B Hill; S Neu; W Knapp; Riitta Alitalo; Kari Alitalo; A Ullrich; Lothar Kanz; Hans-Jörg Bühring
Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase.
Blood 1997;90(1):111-25.
1997: Michael Jeltsch; A Kaipainen; V Joukov; Xiaojuan Meng; Merja Lakso; Heikki Rauvala; M Swartz; D Fukumura; R K Jain; Kari Alitalo
Hyperplasia of lymphatic vessels in VEGF-C transgenic mice.
Science (New York, N.Y.) 1997;276(5317):1423-5.
1997: Berndt Enholm; Kristian J Paavonen; Ari Ristimäki; V Kumar; Y Gunji; Juha Klefstrom; L Kivinen; Marikki Laiho; B Olofsson; V Joukov; Ulf Eriksson; Kari Alitalo
Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia.
Oncogene 1997;14(20):2475-83.
1997: V Joukov; Mauno Vihinen; S Vainikka; J M Sowadski; Kari Alitalo; M Bergman
Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure.
The Biochemical journal 1997;322 ( Pt 3)():927-35.
1997: Piia Vuorela; E Hatva; A Lymboussaki; A Kaipainen; V Joukov; M G Persico; Kari Alitalo; Erja Halmesmäki
Expression of vascular endothelial growth factor and placenta growth factor in human placenta.
Biology of reproduction 1997;56(2):489-94.
1996: E Kukk; A Lymboussaki; Suvi Taira; A Kaipainen; Michael Jeltsch; V Joukov; Kari Alitalo
VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development.
Development (Cambridge, England) 1996;122(12):3829-37.
1996: E Hatva; Juha Jääskeläinen; H Hirvonen; Kari Alitalo; Matti Haltia
Tie endothelial cell-specific receptor tyrosine kinase is upregulated in the vasculature of arteriovenous malformations.
Journal of neuropathology and experimental neurology 1996;55(11):1124-33.
1996: Juha-Pekka Kaukonen; I Lahtinen; Seppo Laine; Kari Alitalo; Aarno Palotie
BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias.
British journal of haematology 1996;94(3):455-60.
1996: B Olofsson; K Pajusola; G von Euler; D Chilov; Kari Alitalo; Ulf Eriksson
Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform.
The Journal of biological chemistry 1996;271(32):19310-7.
1996: P Salvén; Heikki Joensuu; Päivi Heikkilä; M T Matikainen; Veli-Matti Wasenius; A Alanko; Kari Alitalo
Endothelial Tie growth factor receptor provides antigenic marker for assessment of breast cancer angiogenesis.
British journal of cancer 1996;74(1):69-72.
1996: Tom Böhling; E Hatva; M Kujala; L Claesson-Welsh; Kari Alitalo; Matti Haltia
Expression of growth factors and growth factor receptors in capillary hemangioblastoma.
Journal of neuropathology and experimental neurology 1996;55(5):522-7.
1996: V Joukov; K Pajusola; A Kaipainen; D Chilov; I Lahtinen; E Kukk; Olli Saksela; N Kalkkinen; Kari Alitalo
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.
The EMBO journal 1996;15(7):1751.
1996: B Olofsson; K Pajusola; A Kaipainen; G von Euler; V Joukov; O Saksela; Arto Orpana; R F Pettersson; Kari Alitalo; Ulf Eriksson
Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2576-81.
1996: Kristian J Paavonen; N Horelli-Kuitunen; D Chilov; E Kukk; S Pennanen; Olli Kallioniemi; K Pajusola; B Olofsson; Ulf Eriksson; V Joukov; Aarno Palotie; Kari Alitalo
Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively.
Circulation 1996;93(6):1079-82.
1996: P Batard; P Sansilvestri; C Scheinecker; W Knapp; N Debili; W Vainchenker; Hans-Jörg Bühring; Marie-Noëlle Monier; E Kukk; J Partanen; M T Matikainen; Riitta Alitalo; Jacques A Hatzfeld; Kari Alitalo
The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells.
Blood 1996;87(6):2212-20.
1996: E Hatva; Tom Böhling; Juha Jääskeläinen; M G Persico; Matti Haltia; Kari Alitalo
Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas.
The American journal of pathology 1996;148(3):763-75.
1996: S Vainikka; V Joukov; P Klint; Kari Alitalo
Association of a 85-kDa serine kinase with activated fibroblast growth factor receptor-4.
The Journal of biological chemistry 1996;271(3):1270-3.
1996: V Joukov; K Pajusola; A Kaipainen; D Chilov; I Lahtinen; E Kukk; Olli Saksela; N Kalkkinen; Kari Alitalo
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.
The EMBO journal 1996;15(2):290-98.
1996: Kari Alitalo
[Endothelial growth factor and growth factor receptor genes].
Duodecim; lääketieteellinen aikakauskirja 1996;112(4):341-4.
1995: Tomi Mäkelä; E Hellsten; Jouni Vesa; H Hirvonen; Aarno Palotie; Leena Peltonen; Kari Alitalo
The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein.
Oncogene 1995;11(12):2699-704.
1995: M Heiskanen; E Hellsten; Olli Kallioniemi; Tomi Mäkelä; Kari Alitalo; Leena Peltonen; Aarno Palotie
Visual mapping by fiber-FISH.
Genomics 1995;30(1):31-6.
1995: J Korhonen; I Lahtinen; Maria Halmekytö; Leena Alhonen; Juhani Jänne; Daniel J Dumont; Kari Alitalo
Endothelial-specific gene expression directed by the tie gene promoter in vivo.
Blood 1995;86(5):1828-35.
1995: I Västrik; Tomi Mäkelä; Päivi J Koskinen; Kari Alitalo
Determination of sequences responsible for the differential regulation of Myc function by delta Max and Max.
Oncogene 1995;11(3):553-60.
1995: M Laan; Olli Kallioniemi; E Hellsten; Kari Alitalo; Leena Peltonen; Aarno Palotie
Mechanically stretched chromosomes as targets for high-resolution FISH mapping.
Genome research 1995;5(1):13-20.
1995: Tuija Mustonen; Kari Alitalo
Endothelial receptor tyrosine kinases involved in angiogenesis.
The Journal of cell biology 1995;129(4):895-8.
1995: Johanna K Ruohola; Eeva M Valve; S Vainikka; Kari Alitalo; Pirkko L Härkönen
Androgen and fibroblast growth factor (FGF) regulation of FGF receptors in S115 mouse mammary tumor cells.
Endocrinology 1995;136(5):2179-88.
1995: A Kaipainen; J Korhonen; Tuija Mustonen; V W van Hinsbergh; G H Fang; Daniel J Dumont; M Breitman; Kari Alitalo
Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3566-70.
1995: I Västrik; A Kaipainen; T L Penttilä; A Lymboussakis; Riitta Alitalo; Martti Parvinen; Kari Alitalo
Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro.
The Journal of cell biology 1995;128(6):1197-208.
1995: E Hatva; A Kaipainen; P Mentula; Juha Jääskeläinen; A Paetau; Matti Haltia; Kari Alitalo
Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors.
The American journal of pathology 1995;146(2):368-78.
1995: M Bergman; V Joukov; Ismo Virtanen; Kari Alitalo
Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading.
Molecular and cellular biology 1995;15(2):711-22.
1995: E Hellsten; Jouni Vesa; M Heiskanen; Tomi Mäkelä; Irma Järvelä; John Kenneth Cowell; S Mead; Kari Alitalo; Aarno Palotie; Leena Peltonen
Identification of YAC clones for human chromosome 1p32 and physical mapping of the infantile neuronal ceroid lipofuscinosis (INCL) locus.
Genomics 1995;25(2):404-12.
1995: J Laitinen; L Sistonen; Kari Alitalo; Erkki Hölttä
Cell transformation by c-Ha-rasVal12 oncogene is accompanied by a decrease in histone H1 zero and an increase in nucleosomal repeat length.
Journal of cellular biochemistry 1995;57(1):1-11.
1994: A Kaipainen; Tatyana Vlaykova; E Hatva; Tom Böhling; A Jekunen; Seppo Pyrhönen; Kari Alitalo
Enhanced expression of the tie receptor tyrosine kinase mesenger RNA in the vascular endothelium of metastatic melanomas.
Cancer research 1994;54(24):6571-7.
1994: L Tamagnone; I Lahtinen; Tuija Mustonen; Kimmo Virtaneva; F Francis; F Muscatelli; Riitta Alitalo; C I Smith; C Larsson; Kari Alitalo
BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.
Oncogene 1994;9(12):3683-8.
1994: K Pajusola; O Aprelikova; G Pelicci; H Weich; L Claesson-Welsh; Kari Alitalo
Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.
Oncogene 1994;9(12):3545-55.
1994: Juha Klefstrom; I Västrik; Eero Saksela; J Valle; M Eilers; Kari Alitalo
c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha.
The EMBO journal 1994;13(22):5442-50.
1994: S Vainikka; V Joukov; S Wennström; M Bergman; P G Pelicci; Kari Alitalo
Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1.
The Journal of biological chemistry 1994;269(28):18320-6.
1994: C Oetken; Clément Couture; M Bergman; N Bonnefoy-Bérard; Scott Williams; Kari Alitalo; P Burn; Tomas Mustelin
TCR/CD3-triggering causes increased activity of the p50csk tyrosine kinase and engagement of its SH2 domain.
Oncogene 1994;9(6):1625-31.
1994: L Pertovaara; A Kaipainen; Tuija Mustonen; Arto Orpana; N Ferrara; Olli Saksela; Kari Alitalo
Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.
The Journal of biological chemistry 1994;269(9):6271-4.
1994: Päivi J Koskinen; I Västrik; Tomi Mäkelä; Robert N Eisenman; Kari Alitalo
Max activity is affected by phosphorylation at two NH2-terminal sites.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(3):313-20.
1994: J Korhonen; Anne Polvi; J Partanen; Kari Alitalo
The mouse tie receptor tyrosine kinase gene: expression during embryonic angiogenesis.
Oncogene 1994;9(2):395-403.
1994: M Autero; Juha Saharinen; Tiina Pessa-Morikawa; M Soula-Rothhut; C Oetken; M Gassmann; M Bergman; Kari Alitalo; P Burn; Carl G Gahmberg
Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase.
Molecular and cellular biology 1994;14(2):1308-21.
1994: I Västrik; Tomi Mäkelä; Päivi J Koskinen; Juha Klefstrom; Kari Alitalo
Myc protein: partners and antagonists.
Critical reviews in oncogenesis 1994;5(1):59-68.
1993: Anne Polvi; E Armstrong; C Lai; G Lemke; Kay Huebner; R A Spritz; L C Guida; R D Nicholls; Kari Alitalo
The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25.
Gene 1993;134(2):289-93.
1993: A Kaipainen; J Korhonen; K Pajusola; O Aprelikova; M G Persico; B I Terman; Kari Alitalo
The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells.
The Journal of experimental medicine 1993;178(6):2077-88.
1993: K Pajusola; O Aprelikova; E Armstrong; S Morris; Kari Alitalo
Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts.
Oncogene 1993;8(11):2931-7.
1993: Juha Klefstrom; Päivi J Koskinen; Eero Saksela; M Jäättelä; R Bravo; Kari Alitalo
A sub-set of immediate early mRNAs induced by tumor necrosis factor-alpha during cellular cytotoxic and non-cytotoxic responses.
International journal of cancer. Journal international du cancer 1993;55(4):655-9.
1993: Päivi J Koskinen; Tomi Mäkelä; I Västrik; Kari Alitalo
Myc amplification: regulation of myc function.
Clinica chimica acta; international journal of clinical chemistry 1993;217(1):57-62.
1993: L Tamagnone; J Partanen; E Armstrong; J Lasota; K Ohgami; T Tazunoki; S LaForgia; Kay Huebner; Kari Alitalo
The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain.
Oncogene 1993;8(7):2009-14.
1993: E Armstrong; K Kastury; O Aprelikova; F Bullrich; C Nezelof; J Gogusev; J J Wasmuth; Kari Alitalo; S Morris; Kay Huebner
FLT4 receptor tyrosine kinase gene mapping to chromosome band 5q35 in relation to the t(2;5), t(5;6), and t(3;5) translocations.
Genes, chromosomes & cancer 1993;7(3):144-51.
1993: J Partanen; S Vainikka; Kari Alitalo
Structural and functional specificity of FGF receptors.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;340(1293):297-303.
1993: E Hellsten; Jouni Vesa; M C Speer; Tomi Mäkelä; Irma Järvelä; Kari Alitalo; J Ott; Leena Peltonen
Refined assignment of the infantile neuronal ceroid lipofuscinosis (INCL, CLN1) locus at 1p32: incorporation of linkage disequilibrium in multipoint analysis.
Genomics 1993;16(3):720-5.
1993: Domenico Maglione; Vince Guerriero; Giuseppe Viglietto; M G Ferraro; O Aprelikova; Kari Alitalo; S Del Vecchio; K J Lei; J Y Chou; M G Persico
Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14.
Oncogene 1993;8(4):925-31.
1993: L Pertovaara; J Tienari; S Vainikka; J Partanen; Olli Saksela; Eero Lehtonen; Kari Alitalo
Modulation of fibroblast growth factor receptor expression and signalling during retinoic acid-induced differentiation of Tera-2 teratocarcinoma cells.
Biochemical and biophysical research communications 1993;191(1):149-56.
1993: Päivi J Koskinen; Kari Alitalo
Role of myc amplification and overexpression in cell growth, differentiation and death.
Seminars in cancer biology 1993;4(1):3-12.
1993: L Pertovaara; Olli Saksela; Kari Alitalo
Enhanced bFGF gene expression in response to transforming growth factor-beta stimulation of AKR-2B cells.
Growth factors (Chur, Switzerland) 1993;9(1):81-6.
1992: S Vainikka; J Partanen; Paola Bellosta; François Coulier; D Birnbaum; Claudio Basilico; M Jaye; Kari Alitalo
Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction.
The EMBO journal 1992;11(12):4273-80.
1992: J Korhonen; J Partanen; E Armstrong; A Vaahtokari; K Elenius; Markku Jalkanen; Kari Alitalo
Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization.
Blood 1992;80(10):2548-55.
1992: K Pajusola; O Aprelikova; J Korhonen; A Kaipainen; L Pertovaara; Riitta Alitalo; Kari Alitalo
FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.
Cancer research 1992;52(20):5738-43.
1992: Tomi Mäkelä; J Partanen; M Schwab; Kari Alitalo
Plasmid pLTRpoly: a versatile high-efficiency mammalian expression vector.
Gene 1992;118(2):293-4.
1992: M Bergman; Tomas Mustelin; C Oetken; J Partanen; N A Flint; Kurt Amrein; M Autero; P Burn; Kari Alitalo
The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.
The EMBO journal 1992;11(8):2919-24.
1992: J A Warrington; S K Bailey; E Armstrong; O Aprelikova; Kari Alitalo; G M Dolganov; A S Wilcox; James M Sikela; S F Wolfe; Michael Lovett
A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5.
Genomics 1992;13(3):803-8.
1992: J Korhonen; J Partanen; Kari Alitalo
Expression of FGFR-4 mRNA in developing mouse tissues.
The International journal of developmental biology 1992;36(2):323-9.
1992: Tomi Mäkelä; E Hellsten; Jouni Vesa; Kari Alitalo; Leena Peltonen
An Alu variable polyA repeat polymorphism upstream of L-myc at 1p32.
Human molecular genetics 1992;1(3):217.
1992: Tomi Mäkelä; K Saksela; Kari Alitalo
Amplification and rearrangement of L-myc in human small-cell lung cancer.
Mutation research 1992;276(3):307-15.
1992: Tomi Mäkelä; Päivi J Koskinen; I Västrik; Kari Alitalo
Alternative forms of Max as enhancers or suppressors of Myc-ras cotransformation.
Science (New York, N.Y.) 1992;256(5055):373-7.
1992: J Partanen; E Armstrong; Tomi Mäkelä; J Korhonen; M Sandberg; R Renkonen; S Knuutila; Kay Huebner; Kari Alitalo
A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.
Molecular and cellular biology 1992;12(4):1698-707.
1992: Tomi Mäkelä; M Shiraishi; M G Borrello; T Sekiya; Kari Alitalo
Rearrangement and co-amplification of L-myc and rlf in primary lung cancer.
Oncogene 1992;7(3):405-9.
1992: L Lehtola; J Partanen; L Sistonen; J Korhonen; A Wärri; P Härkönen; Robert Clarke; Kari Alitalo
Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF-7 breast-cancer cells.
International journal of cancer. Journal international du cancer 1992;50(4):598-603.
1992: K Saksela; Tomi Mäkelä; K Hughes; J R Woodgett; Kari Alitalo
Activation of protein kinase C increases phosphorylation of the L-myc trans-activator domain at a GSK-3 target site.
Oncogene 1992;7(2):347-53.
1992: O Aprelikova; K Pajusola; J Partanen; E Armstrong; Riitta Alitalo; S K Bailey; J McMahon; J Wasmuth; Kay Huebner; Kari Alitalo
FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter.
Cancer research 1992;52(3):746-8.
1992: E Armstrong; Linda Cannizzaro; M Bergman; Kay Huebner; Kari Alitalo
The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25.
Cytogenetics and cell genetics 1992;60(2):119-20.
1992: E Armstrong; J Partanen; Linda Cannizzaro; Kay Huebner; Kari Alitalo
Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter.
Genes, chromosomes & cancer 1992;4(1):94-8.
1992: L Lehtola; H Lehväslaiho; P Koskinen; Kari Alitalo
A chimeric EGFR/neu receptor in studies of neu function.
Cancer treatment and research 1992;61():213-28.
1992: L Lehtola; H Lehväslaiho; P Koskinen; Kari Alitalo
A chimeric EGFR/neu receptor in functional analysis of the neu oncoprotein.
Acta oncologica (Stockholm, Sweden) 1992;31(2):147-50.
1992: J Partanen; S Vainikka; J Korhonen; E Armstrong; Kari Alitalo
Diverse receptors for fibroblast growth factors.
Progress in growth factor research 1992;4(1):69-83.
1992: J Korhonen; J Partanen; E Eerola; S Vainikka; Riitta Alitalo; Tomi Mäkelä; M Sandberg; H Hirvonen; Kari Alitalo
Five FGF receptors with distinct expression patterns.
EXS 1992;61():91-100.
1991: J Partanen; E Armstrong; M Bergman; Tomi Mäkelä; H Hirvonen; Kay Huebner; Kari Alitalo
cyl encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src).
Oncogene 1991;6(11):2013-8.
1991: E Armstrong; J Hästbacka; J Partanen; Kay Huebner; Kari Alitalo
RFLPs in the fibroblast growth factor receptor-4 locus (FGFR4) in 5q33-qter.
Nucleic acids research 1991;19(18):5096.
1991: L Lehtola; M Nistér; Erkki Hölttä; B Westermark; Kari Alitalo
Down-regulation of cellular platelet-derived growth factor receptors induced by an activated neu receptor tyrosine kinase.
Cell regulation 1991;2(8):651-61.
1991: Tomi Mäkelä; Juha Kere; R Winqvist; Kari Alitalo
Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer.
Molecular and cellular biology 1991;11(8):4015-21.
1991: Tomi Mäkelä; K Saksela; G Evan; Kari Alitalo
A fusion protein formed by L-myc and a novel gene in SCLC.
The EMBO journal 1991;10(6):1331-5.
1991: J Partanen; Tomi Mäkelä; E Eerola; J Korhonen; H Hirvonen; L Claesson-Welsh; Kari Alitalo
FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.
The EMBO journal 1991;10(6):1347-54.
1991: Päivi J Koskinen; L Sistonen; G Evan; R Morimoto; Kari Alitalo
Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells.
Journal of virology 1991;65(2):842-51.
1991: K Saksela; Päivi J Koskinen; Kari Alitalo
Binding of a nuclear factor to the upstream region of the c-myc gene.
Oncogene research 1991;6(1):73-6.
1991: Päivi J Koskinen; L Sistonen; R Bravo; Kari Alitalo
Immediate early gene responses of NIH 3T3 fibroblasts and NMuMG epithelial cells to TGF beta-1.
Growth factors (Chur, Switzerland) 1991;5(4):283-93.
1991: L Lehtola; L Sistonen; P Koskinen; H Lehväslaiho; M F Di Renzo; paolo comoglio; Kari Alitalo
Constitutively activated neu oncoprotein tyrosine kinase interferes with growth factor-induced signals for gene activation.
Journal of cellular biochemistry 1991;45(1):69-81.
1991: I Västrik; Tomi Mäkelä; Päivi J Koskinen; K Saksela; Kari Alitalo
myc, max, and a novel rlf-L-myc fusion protein in small-cell lung cancer.
Princess Takamatsu symposia 1991;22():307-18.
1991: J Korhonen; J Partanen; E Eerola; S Vainikka; V Ilvesmäki; Raimo Voutilainen; M Julkunen; Tomi Mäkelä; Kari Alitalo
Novel human FGF receptors with distinct expression patterns.
Annals of the New York Academy of Sciences 1991;638():403-5.
1991: Tomi Mäkelä; Karin Mattson; Kari Alitalo
Tumour markers and oncogenes in lung cancer.
European journal of cancer (Oxford, England : 1990) 1991;27(10):1323-7.
1990: H Hirvonen; Tomi Mäkelä; M Sandberg; Hannu Kalimo; Eero Vuorio; Kari Alitalo
Expression of the myc proto-oncogenes in developing human fetal brain.
Oncogene 1990;5(12):1787-97.
1990: J Partanen; Tomi Mäkelä; Riitta Alitalo; H Lehväslaiho; Kari Alitalo
Putative tyrosine kinases expressed in K-562 human leukemia cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8913-7.
1990: J Laitinen; L Sistonen; Kari Alitalo; Erkki Hölttä
c-Ha-rasVal 12 oncogene-transformed NIH-3T3 fibroblasts display more decondensed nucleosomal organization than normal fibroblasts.
The Journal of cell biology 1990;111(1):9-17.
1990: L Sistonen; Päivi J Koskinen; H Lehväslaiho; L Lehtola; R Bravo; Kari Alitalo
Downregulation of the early genomic growth factor response in neu oncogene-transformed cells.
Oncogene 1990;5(6):815-21.
1990: Riitta Alitalo; J Partanen; L Pertovaara; Erkki Hölttä; L Sistonen; L Andersson; Kari Alitalo
Increased erythroid potentiating activity/tissue inhibitor of metalloproteinases and jun/fos transcription factor complex characterize tumor promoter-induced megakaryoblastic differentiation of K562 leukemia cells.
Blood 1990;75(10):1974-82.
1990: P Koskinen; H Lehväslaiho; H MacDonald-Bravo; Kari Alitalo; R Bravo
Similar early gene responses to ligand-activated EGFR and neu tyrosine kinases in NIH3T3 cells.
Oncogene 1990;5(4):615-8.
1990: H Lehväslaiho; L Sistonen; F diRenzo; J Partanen; P Comoglio; Erkki Hölttä; Kari Alitalo
Regulation by EGF is maintained in an overexpressed chimeric EGFR/neu receptor tyrosine kinase.
Journal of cellular biochemistry 1990;42(3):123-33.
1989: L Sistonen; Erkki Hölttä; H Lehväslaiho; L Lehtola; Kari Alitalo
Activation of the neu tyrosine kinase induces the fos/jun transcription factor complex, the glucose transporter and ornithine decarboxylase.
The Journal of cell biology 1989;109(5):1911-9.
1989: K Saksela; Tomi Mäkelä; Kari Alitalo
Oncogene expression in small-cell lung cancer cell lines and a testicular germ-cell tumor: activation of the N-myc gene and decreased RB mRNA.
International journal of cancer. Journal international du cancer 1989;44(1):182-5.
1989: M Sihvola; L Sistonen; Kari Alitalo; M Hurme
Mechanism of T cell proliferation in vivo: analysis of IL-2 receptor expression and activation of c-myc and c-myb oncogenes during lymphatic regeneration.
Biochemical and biophysical research communications 1989;160(1):181-8.
1989: Tomi Mäkelä; K Saksela; Kari Alitalo
Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene.
Molecular and cellular biology 1989;9(4):1545-52.
1989: M Hurme; M Sihvola; Kari Alitalo; Jorma Keski-Oja
Transforming growth factor-beta does not alter interleukin-1 expression in cultured human macrophages.
Journal of cellular biochemistry 1989;39(4):467-75.
1989: L Pertovaara; L Sistonen; T J Bos; P K Vogt; Jorma Keski-Oja; Kari Alitalo
Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation.
Molecular and cellular biology 1989;9(3):1255-62.
1989: catherine legraverend; A Potter; Erkki Hölttä; Kari Alitalo; Leif C Andersson
Interleukin-2 induces a rapid increase in ornithine decarboxylase mRNA in a cloned murine T lymphocytic cell line.
Experimental cell research 1989;181(1):273-81.
1989: H Hirvonen; M Sandberg; Hannu Kalimo; Veijo Hukkanen; Eero Vuorio; Toivo T Salmi; Kari Alitalo
The N-myc proto-oncogene and IGF-II growth factor mRNAs are expressed by distinct cells in human fetal kidney and brain.
The Journal of cell biology 1989;108(3):1093-104.
1989: L Sistonen; Erkki Hölttä; Tomi Mäkelä; Jorma Keski-Oja; Kari Alitalo
The cellular response to induction of the p21 c-Ha-ras oncoprotein includes stimulation of jun gene expression.
The EMBO journal 1989;8(3):815-22.
1989: L Lehtola; H Lehväslaiho; L Sistonen; L Beguinot; Kari Alitalo
Receptor downregulation and DNA synthesis are modulated by EGF and TPA in cells expressing an EGFR/neu chimera.
Growth factors (Chur, Switzerland) 1989;1(4):323-34.
1989: H Lehväslaiho; L Lehtola; L Sistonen; Kari Alitalo
A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation.
The EMBO journal 1989;8(1):159-66.
1989: K Saksela; Tomi Mäkelä; G Evan; Kari Alitalo
Rapid phosphorylation of the L-myc protein induced by phorbol ester tumor promoters and serum.
The EMBO journal 1989;8(1):149-57.
1988: T Vuorio; A Wärri; M Sandberg; Kari Alitalo; Eero Vuorio
Expression of the c-Ha-ras and neu oncogenes in DMBA-induced, anti-estrogen-treated rat mammary tumors.
International journal of cancer. Journal international du cancer 1988;42(5):774-9.
1988: Riitta Alitalo; Tomi Mäkelä; P Koskinen; Leif C Andersson; Kari Alitalo
Enhanced expression of transforming growth factor beta during megakaryoblastic differentiation of K562 leukemia cells.
Blood 1988;71(4):899-906.
1988: Erkki Hölttä; L Sistonen; Kari Alitalo
The mechanisms of ornithine decarboxylase deregulation in c-Ha-ras oncogene-transformed NIH 3T3 cells.
The Journal of biological chemistry 1988;263(9):4500-7.
1988: M Sandberg; T Vuorio; H Hirvonen; Kari Alitalo; Eero Vuorio
Enhanced expression of TGF-beta and c-fos mRNAs in the growth plates of developing human long bones.
Development (Cambridge, England) 1988;102(3):461-70.
1987: Tomi Mäkelä; Riitta Alitalo; Y Paulsson; B Westermark; C H Heldin; Kari Alitalo
Regulation of platelet-derived growth factor gene expression by transforming growth factor beta and phorbol ester in human leukemia cell lines.
Molecular and cellular biology 1987;7(10):3656-62.
1987: Kari Alitalo; P Koskinen; Tomi Mäkelä; K Saksela; L Sistonen; R Winqvist
myc oncogenes: activation and amplification.
Biochimica et biophysica acta 1987;907(1):1-32.
1987: L Alhonen-Hongisto; P Leinonen; Riitta Sinervirta; R Laine; R Winqvist; Kari Alitalo; Olli A Jänne; Juhani Jänne
Mouse and human ornithine decarboxylase genes. Methylation polymorphism and amplification.
The Biochemical journal 1987;242(1):205-10.
1987: L Sistonen; Jorma Keski-Oja; I Ulmanen; Erkki Hölttä; B J Wikgren; Kari Alitalo
Dose effects of transfected c-Ha-rasVal 12 oncogene in transformed cell clones.
Experimental cell research 1987;168(2):518-30.
1986: R Winqvist; Tomi Mäkelä; P Seppänen; Olli A Jänne; L Alhonen-Hongisto; Juhani Jänne; K H Grzeschik; Kari Alitalo
Human ornithine decarboxylase sequences map to chromosome regions 2pter----p23 and 7cen----qter but are not coamplified with the NMYC oncogene.
Cytogenetics and cell genetics 1986;42(3):133-40.
1985: Kari Alitalo; K Saksela; R Winqvist; R Alitalo; Jorma Keski-Oja; M Laiho; M Ilvonen; Sakari Knuutila; Albert de La Chapelle
Acute myelogenous leukaemia with c-myc amplification and double minute chromosomes.
Lancet 1985;2(8463):1035-9.
1984: R Winqvist; K Saksela; Kari Alitalo
The myc proteins are not associated with chromatin in mitotic cells.
The EMBO journal 1984;3(12):2947-50.