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Kari Alitalo

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Physiology

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Publications

TOP 3
Hogan Benjamin M; Herpers Robert; Witte Merlijn; Heloterä Hanna; Alitalo Kari; Duckers Henricus J; Schulte-Merker Stefan
Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.
Mouta-Bellum Carla; Kirov Aleksander; Miceli-Libby Laura; Mancini Maria L; Petrova Tatiana V; Liaw Lucy; Prudovsky Igor; Thorpe Philip E; Miura Naoyuki; Cantley Lewis C; Alitalo Kari; Fruman David A; Vary Calvin P H
Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha.
Holopainen Tanja; Huang Huilian; Chen Caiping; Kim Kyung Eun; Zhang Luqing; Zhou Fei; Han Wencan; Li Chaojun; Yu Jun; Wu Jun; Koh Gou Young; Alitalo Kari; He Yulong
Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment.

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All Publications

2009: Hogan Benjamin M; Herpers Robert; Witte Merlijn; Heloterä Hanna; Alitalo Kari; Duckers Henricus J; Schulte-Merker Stefan
Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.
Development (Cambridge, England) 2009;136(23):4001-9.
2009: Mouta-Bellum Carla; Kirov Aleksander; Miceli-Libby Laura; Mancini Maria L; Petrova Tatiana V; Liaw Lucy; Prudovsky Igor; Thorpe Philip E; Miura Naoyuki; Cantley Lewis C; Alitalo Kari; Fruman David A; Vary Calvin P H
Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha.
Developmental dynamics : an official publication of the American Association of Anatomists 2009;238(10):2670-9.
2009: Holopainen Tanja; Huang Huilian; Chen Caiping; Kim Kyung Eun; Zhang Luqing; Zhou Fei; Han Wencan; Li Chaojun; Yu Jun; Wu Jun; Koh Gou Young; Alitalo Kari; He Yulong
Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment.
Cancer research 2009;69(11):4656-64.
2009: Anisimov Andrey; Alitalo Annamari; Korpisalo Petra; Soronen Jarkko; Kaijalainen Seppo; Leppänen Veli-Matti; Jeltsch Michael; Ylä-Herttuala Seppo; Alitalo Kari
Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle.
Circulation research 2009;104(11):1302-12.
2009: Machnik Agnes; Neuhofer Wolfgang; Jantsch Jonathan; Dahlmann Anke; Tammela Tuomas; Machura Katharina; Park Joon-Keun; Beck Franz-Xaver; Müller Dominik N; Derer Wolfgang; Goss Jennifer; Ziomber Agata; Dietsch Peter; Wagner Hubertus; van Rooijen Nico; Kurtz Armin; Hilgers Karl F; Alitalo Kari; Eckardt Kai-Uwe; Luft Friedrich C; Kerjaschki Dontscho; Titze Jens
Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.
Nature medicine 2009;15(5):545-52.
2009: Norrmén Camilla; Ivanov Konstantin I; Cheng Jianpin; Zangger Nadine; Delorenzi Mauro; Jaquet Muriel; Miura Naoyuki; Puolakkainen Pauli; Horsley Valerie; Hu Junhao; Augustin Hellmut G; Ylä-Herttuala Seppo; Alitalo Kari; Petrova Tatiana V
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1.
The Journal of cell biology 2009;185(3):439-57.
2009: Kataru Raghu P; Jung Keehoon; Jang Cholsoon; Yang Hanseul; Schwendener Reto A; Baik Jung Eun; Han Seung Hyun; Alitalo Kari; Koh Gou Young
Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution.
Blood 2009;113(22):5650-9.
2009: Tuuminen Raimo; Nykänen Antti I; Krebs Rainer; Soronen Jarkko; Pajusola Katri; Keränen Mikko A I; Koskinen Petri K; Alitalo Kari; Lemström Karl B
PDGF-A, -C, and -D but not PDGF-B increase TGF-beta1 and chronic rejection in rat cardiac allografts.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(5):691-8.
2009: Lohela Marja; Bry Maija; Tammela Tuomas; Alitalo Kari
VEGFs and receptors involved in angiogenesis versus lymphangiogenesis.
Current opinion in cell biology 2009;21(2):154-65.
2009: Augustin Hellmut G; Koh Gou Young; Thurston Gavin; Alitalo Kari
Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system.
Nature reviews. Molecular cell biology 2009;10(3):165-77.
2009: Lähteenvuo Johanna E; Lähteenvuo Markku T; Kivelä Antti; Rosenlew Carolina; Falkevall Annelie; Klar Joakim; Heikura Tommi; Rissanen Tuomas T; Vähäkangas Elisa; Korpisalo Petra; Enholm Berndt; Carmeliet Peter; Alitalo Kari; Eriksson Ulf; Ylä-Herttuala Seppo
Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms.
Circulation 2009;119(6):845-56.
2009: Sallinen Hanna; Anttila Maarit; Narvainen Johanna; Koponen Jonna; Hamalainen Kirsi; Kholova Ivana; Heikura Tommi; Toivanen Pyry; Kosma Veli-Matti; Heinonen Seppo; Alitalo Kari; Yla-Herttuala Seppo
Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(2):278-84.
2009: Verstraeten Valerie L R M; Holnthoner Wolfgang; van Steensel Maurice A M; Veraart Joep C J M; Bladergroen Reno S; Heckman Caroline A; Keskitalo Salla; Frank Jorge; Alitalo Kari; van Geel Michel; Steijlen Peter M
Functional analysis of FLT4 mutations associated with Nonne-Milroy lymphedema.
The Journal of investigative dermatology 2009;129(2):509-12.
2008: Mitchell-Jordan Scherise A; Holopainen Tanja; Ren Shuxun; Wang Sujing; Warburton Sarah; Zhang Michael J; Alitalo Kari; Wang Yibin; Vondriska Thomas M
Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy.
Circulation research 2008;103(12):1359-62.
2008: Lohela Marja; Heloterä Hanna; Haiko Paula; Dumont Daniel J; Alitalo Kari
Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues.
The American journal of pathology 2008;173(6):1891-901.
2008: Korpisalo Petra; Karvinen Henna; Rissanen Tuomas T; Kilpijoki Johanna; Marjomäki Varpu; Baluk Peter; McDonald Donald M; Cao Yihai; Eriksson Ulf; Alitalo Kari; Ylä-Herttuala Seppo
Vascular endothelial growth factor-A and platelet-derived growth factor-B combination gene therapy prolongs angiogenic effects via recruitment of interstitial mononuclear cells and paracrine effects rather than improved pericyte coverage of angiogenic vessels.
Circulation research 2008;103(10):1092-9.
2008: Burton Jeremy B; Priceman Saul J; Sung James L; Brakenhielm Ebba; An Dong Sung; Pytowski Bronislaw; Alitalo Kari; Wu Lily
Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis.
Cancer research 2008;68(19):7828-37.
2008: Karpanen Terhi; Bry Maija; Ollila Hanna M; Seppänen-Laakso Tuulikki; Liimatta Erkki; Leskinen Hanna; Kivelä Riikka; Helkamaa Teemu; Merentie Mari; Jeltsch Michael; Paavonen Karri; Andersson Leif C; Mervaala Eero; Hassinen Ilmo E; Ylä-Herttuala Seppo; Oresic Matej; Alitalo Kari
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy.
Circulation research 2008;103(9):1018-26.
2008: Kirjavainen Anna; Sulg Marilin; Heyd Florian; Alitalo Kari; Ylä-Herttuala Seppo; Möröy Tarik; Petrova Tatiana V; Pirvola Ulla
Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia.
Developmental biology 2008;322(1):33-45.
2008: Karpanen Terhi; Alitalo Kari
VEGF-D: a modifier of embryonic lymphangiogenesis.
Blood 2008;112(5):1547-8.
2008: Li Xuri; Tjwa Marc; Van Hove Inge; Enholm Berndt; Neven Elke; Paavonen Karri; Jeltsch Michael; Juan Toni Diez; Sievers Richard E; Chorianopoulos Emmanuel; Wada Hiromichi; Vanwildemeersch Maarten; Noel Agnes; Foidart Jean-Michel; Springer Matthew L; von Degenfeld Georges; Dewerchin Mieke; Blau Helen M; Alitalo Kari; Eriksson Ulf; Carmeliet Peter; Moons Lieve
Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(9):1614-20.
2008: Haiko Paula; Makinen Taija; Keskitalo Salla; Taipale Jussi; Karkkainen Marika J; Baldwin Megan E; Stacker Steven A; Achen Marc G; Alitalo Kari
Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos.
Molecular and cellular biology 2008;28(15):4843-50.
2008: Tammela Tuomas; Zarkada Georgia; Wallgard Elisabet; Murtomäki Aino; Suchting Steven; Wirzenius Maria; Waltari Marika; Hellström Mats; Schomber Tibor; Peltonen Reetta; Freitas Catarina; Duarte Antonio; Isoniemi Helena; Laakkonen Pirjo; Christofori Gerhard; Ylä-Herttuala Seppo; Shibuya Masabumi; Pytowski Bronislaw; Eichmann Anne; Betsholtz Christer; Alitalo Kari
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.
Nature 2008;454(7204):656-60.
2008: Heckman Caroline A; Holopainen Tanja; Wirzenius Maria; Keskitalo Salla; Jeltsch Michael; Ylä-Herttuala Seppo; Wedge Stephen R; Jürgensmeier Juliane M; Alitalo Kari
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis.
Cancer research 2008;68(12):4754-62.
2008: Petrova Tatiana V; Bono Petri; Holnthoner Wolfgang; Chesnes Jessica; Pytowski Bronislaw; Sihto Harri; Laakkonen Pirjo; Heikkilä Päivi; Joensuu Heikki; Alitalo Kari
VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors.
Cancer cell 2008;13(6):554-6.
2008: Melcher Martin; Unger Bernd; Schmidt Uwe; Rajantie Iiro A; Alitalo Kari; Ellmeier Wilfried
Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):8048-56.
2008: Petrova Tatiana V; Nykänen Antti; Norrmén Camilla; Ivanov Konstantin I; Andersson Leif C; Haglund Caj; Puolakkainen Pauli; Wempe Frank; von Melchner Harald; Gradwohl Gérard; Vanharanta Sakari; Aaltonen Lauri A; Saharinen Juha; Gentile Massimiliano; Clarke Alan; Taipale Jussi; Oliver Guillermo; Alitalo Kari
Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.
Cancer cell 2008;13(5):407-19.
2008: Purhonen Susanna; Palm Jarmo; Rossi Derrick; Kaskenpää Nina; Rajantie Iiro; Ylä-Herttuala Seppo; Alitalo Kari; Weissman Irving L; Salven Petri
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(18):6620-5.
2008: Bruyère Françoise; Melen-Lamalle Laurence; Blacher Silvia; Roland Guy; Thiry Marc; Moons Lieve; Frankenne Francis; Carmeliet Peter; Alitalo Kari; Libert Claude; Sleeman Jonathan P; Foidart Jean-Michel; Noël Agnès
Modeling lymphangiogenesis in a three-dimensional culture system.
Nature methods 2008;5(5):431-7.
2008: Saharinen Pipsa; Eklund Lauri; Miettinen Juho; Wirkkala Riikka; Anisimov Andrey; Winderlich Mark; Nottebaum Astrid; Vestweber Dietmar; Deutsch Urban; Koh Gou Young; Olsen Bjorn R; Alitalo Kari
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts.
Nature cell biology 2008;10(5):527-37.
2008: Benest Andrew V; Harper Steven J; Herttuala Seppo Yla; Alitalo Kari; Bates David O
VEGF-C induced angiogenesis preferentially occurs at a distance from lymphangiogenesis.
Cardiovascular research 2008;78(2):315-23.
2008: Jeon Bong-Hyun; Jang Cholsoon; Han Jinah; Kataru Raghu P; Piao Lianhua; Jung Keehoon; Cha Hye Ji; Schwendener Reto A; Jang Kyu Yun; Kim Kwan-Sik; Alitalo Kari; Koh Gou Young
Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer.
Cancer research 2008;68(4):1100-9.
2008: Karpanen Terhi; Alitalo Kari
Molecular biology and pathology of lymphangiogenesis.
Annual review of pathology 2008;3():367-97.
2007: Brideau Gaëlle; Mäkinen Markus J; Elamaa Harri; Tu Hongmin; Nilsson Gunnar; Alitalo Kari; Pihlajaniemi Taina; Heljasvaara Ritva
Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice.
Cancer research 2007;67(24):11528-35.
2007: Ylä-Herttuala Seppo; Alitalo Kari
On the relationship of LDL and VEGFR1: not just a family affair.
EMBO reports 2007;8(12):1127-8.
2007: Tammela Tuomas; Saaristo Anne; Holopainen Tanja; Lyytikkä Johannes; Kotronen Anna; Pitkonen Miia; Abo-Ramadan Usama; Ylä-Herttuala Seppo; Petrova Tatiana V; Alitalo Kari
Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation.
Nature medicine 2007;13(12):1458-66.
2007: Brakenhielm Ebba; Burton Jeremy B; Johnson Mai; Chavarria Nelson; Morizono Kouki; Chen Irvin; Alitalo Kari; Wu Lily
Modulating metastasis by a lymphangiogenic switch in prostate cancer.
International journal of cancer. Journal international du cancer 2007;121(10):2153-61.
2007: Koopal Sonja; Furuhjelm Johanna H; Järviluoma Annika; Jäämaa Sari; Pyakurel Pawan; Pussinen Christel; Wirzenius Maria; Biberfeld Peter; Alitalo Kari; Laiho Marikki; Ojala Päivi M
Viral oncogene-induced DNA damage response is activated in Kaposi sarcoma tumorigenesis.
PLoS pathogens 2007;3(9):1348-60.
2007: Heloterä Hanna; Alitalo Kari
The VEGF family, the inside story.
Cell 2007;130(4):591-2.
2007: Gupta Surbhi; Ramjaun Antoine R; Haiko Paula; Wang Yihua; Warne Patricia H; Nicke Barbara; Nye Emma; Stamp Gordon; Alitalo Kari; Downward Julian
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.
Cell 2007;129(5):957-68.
2007: Wirzenius Maria; Tammela Tuomas; Uutela Marko; He Yulong; Odorisio Teresa; Zambruno Giovanna; Nagy Janice A; Dvorak Harold F; Ylä-Herttuala Seppo; Shibuya Masabumi; Alitalo Kari
Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting.
The Journal of experimental medicine 2007;204(6):1431-40.
2007: Adams Ralf H; Alitalo Kari
Molecular regulation of angiogenesis and lymphangiogenesis.
Nature reviews. Molecular cell biology 2007;8(6):464-78.
2007: Keskitalo Salla; Tammela Tuomas; Lyytikka Johannes; Karpanen Terhi; Jeltsch Michael; Markkanen Johanna; Yla-Herttuala Seppo; Alitalo Kari
Enhanced capillary formation stimulated by a chimeric vascular endothelial growth factor/vascular endothelial growth factor-C silk domain fusion protein.
Circulation research 2007;100(10):1460-7.
2007: Tammela Tuomas; He Yulong; Lyytikkä Johannes; Jeltsch Michael; Markkanen Johanna; Pajusola Katri; Ylä-Herttuala Seppo; Alitalo Kari
Distinct architecture of lymphatic vessels induced by chimeric vascular endothelial growth factor-C/vascular endothelial growth factor heparin-binding domain fusion proteins.
Circulation research 2007;100(10):1468-75.
2007: Kopfstein Lucie; Veikkola Tanja; Djonov Valentin G; Baeriswyl Vanessa; Schomber Tibor; Strittmatter Karin; Stacker Steven A; Achen Marc G; Alitalo Kari; Christofori Gerhard
Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis.
The American journal of pathology 2007;170(4):1348-61.
2007: Raisky Olivier; Nykänen Antti I; Krebs Rainer; Hollmén Maria; Keränen Mikko A I; Tikkanen Jussi M; Sihvola Roope; Alhonen Leena; Salven Petri; Wu Yan; Hicklin Daniel J; Alitalo Kari; Koskinen Petri K; Lemström Karl B
VEGFR-1 and -2 regulate inflammation, myocardial angiogenesis, and arteriosclerosis in chronically rejecting cardiac allografts.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(4):819-25.
2007: McColl Bradley K; Paavonen Karri; Karnezis Tara; Harris Nicole C; Davydova Natalia; Rothacker Julie; Nice Edouard C; Harder Kenneth W; Roufail Sally; Hibbs Margaret L; Rogers Peter A W; Alitalo Kari; Stacker Steven A; Achen Marc G
Proprotein convertases promote processing of VEGF-D, a critical step for binding the angiogenic receptor VEGFR-2.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(4):1088-98.
2007: Hirakawa Satoshi; Brown Lawrence F; Kodama Shohta; Paavonen Karri; Alitalo Kari; Detmar Michael
VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites.
Blood 2007;109(3):1010-7.
2007: Laakkonen Pirjo; Waltari Marika; Holopainen Tanja; Takahashi Takashi; Pytowski Bronislaw; Steiner Philipp; Hicklin Daniel; Persaud Kris; Tonra James R; Witte Larry; Alitalo Kari
Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth.
Cancer research 2007;67(2):593-9.
2007: Wick Nikolaus; Saharinen Pipsa; Saharinen Juha; Gurnhofer Elisabeth; Steiner Carl W; Raab Ingrid; Stokic Dejan; Giovanoli Pietro; Buchsbaum Sabine; Burchard Aurea; Thurner Stefan; Alitalo Kari; Kerjaschki Dontscho
Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitro.
Physiological genomics 2007;28(2):179-92.
2007: Mäkinen Taija; Alitalo Kari
Lymphangiogenesis in development and disease.
Novartis Foundation symposium 2007;283():87-98; discussion 98-105, 238-41.
2007: Stacker Steven A; Farnsworth Rae H; Karnezis Tara; Shayan Ramin; Smith Darrin P; Paavonen Karri; Davydova Natalia; Caesar Carol; Inder Rachael; Baldwin Megan E; McColl Bradley K; Roufail Sally; Williams Richard A; Hughes Richard A; Alitalo Kari; Achen Marc G
Molecular pathways for lymphangiogenesis and their role in human disease.
Novartis Foundation symposium 2007;281():38-43; discussion 44-53, 208-9.
2006: Tuuminen R; Nykänen A; Keränen M A; Krebs R; Alitalo K; Koskinen P K; Lemström K B
The effect of platelet-derived growth factor ligands in rat cardiac allograft vasculopathy and fibrosis.
Transplantation proceedings 2006;38(10):3271-3.
2006: Schaffhauser Birgit; Veikkola Tanja; Strittmatter Karin; Antoniadis Helena; Alitalo Kari; Christofori Gerhard
Moderate antiangiogenic activity by local, transgenic expression of endostatin in Rip1Tag2 transgenic mice.
Journal of leukocyte biology 2006;80(4):669-76.
2006: Saaristo Anne; Tammela Tuomas; Farkkila Anniina; Kärkkäinen Marika; Suominen Erkki; Yla-Herttuala Seppo; Alitalo Kari
Vascular endothelial growth factor-C accelerates diabetic wound healing.
The American journal of pathology 2006;169(3):1080-7.
2006: He Yun; Luo Yan; Tang Shibo; Rajantie Iiro; Salven Petri; Heil Matthias; Zhang Rong; Luo Dianhong; Li Xianghong; Chi Hongbo; Yu Jun; Carmeliet Peter; Schaper Wolfgang; Sinusas Albert J; Sessa William C; Alitalo Kari; Min Wang
Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis.
The Journal of clinical investigation 2006;116(9):2344-55.
2006: Zheng Yujuan; Murakami Masato; Takahashi Hiroyuki; Yamauchi Mai; Kiba Atsushi; Yamaguchi Sachiko; Yabana Naoyuki; Alitalo Kari; Shibuya Masabumi
Chimeric VEGF-E(NZ7)/PlGF promotes angiogenesis via VEGFR-2 without significant enhancement of vascular permeability and inflammation.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(9):2019-26.
2006: Karpanen Terhi; Wirzenius Maria; Mäkinen Taija; Veikkola Tanja; Haisma Hidde J; Achen Marc G; Stacker Steven A; Pytowski Bronislaw; Ylä-Herttuala Seppo; Alitalo Kari
Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation.
The American journal of pathology 2006;169(2):708-18.
2006: Janér Joakim; Lassus Patrik; Haglund Caj; Paavonen Karri; Alitalo Kari; Andersson Sture
Pulmonary vascular endothelial growth factor-C in development and lung injury in preterm infants.
American journal of respiratory and critical care medicine 2006;174(3):326-30.
2006: Kärpänen Terhi; Heckman Caroline A; Keskitalo Salla; Jeltsch Michael; Ollila Hanna; Neufeld Gera; Tamagnone Luca; Alitalo Kari
Functional interaction of VEGF-C and VEGF-D with neuropilin receptors.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(9):1462-72.
2006: Karlsen Tine V; Karkkainen Marika J; Alitalo Kari; Wiig Helge
Transcapillary fluid balance consequences of missing initial lymphatics studied in a mouse model of primary lymphoedema.
The Journal of physiology 2006;574(Pt 2):583-96.
2006: Nykänen Antti I; Pajusola Katri; Krebs Rainer; Keränen Mikko A I; Raisky Olivier; Koskinen Petri K; Alitalo Kari; Lemström Karl B
Common protective and diverse smooth muscle cell effects of AAV-mediated angiopoietin-1 and -2 expression in rat cardiac allograft vasculopathy.
Circulation research 2006;98(11):1373-80.
2006: Kreuger Johan; Nilsson Ingrid; Kerjaschki Dontscho; Petrova Tatiana; Alitalo Kari; Claesson-Welsh Lena
Early lymph vessel development from embryonic stem cells.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(5):1073-8.
2006: Brindle Nicholas P J; Saharinen Pipsa; Alitalo Kari
Signaling and functions of angiopoietin-1 in vascular protection.
Circulation research 2006;98(8):1014-23.
2006: Jeltsch Michael; Karpanen Terhi; Strandin Tomas; Aho Kukka; Lankinen Hilkka; Alitalo Kari
Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns.
The Journal of biological chemistry 2006;281(17):12187-95.
2006: Takemoto Minoru; He Liqun; Norlin Jenny; Patrakka Jaakko; Xiao Zhijie; Petrova Tatiana; Bondjers Cecilia; Asp Julia; Wallgard Elisabet; Sun Ying; Samuelsson Tore; Mostad Petter; Lundin Samuel; Miura Naoyuki; Sado Yoshikazu; Alitalo Kari; Quaggin Susan E; Tryggvason Karl; Betsholtz Christer
Large-scale identification of genes implicated in kidney glomerulus development and function.
The EMBO journal 2006;25(5):1160-74.
2006: Le Bras Barbara; Barallobre Maria-José; Homman-Ludiye Jihane; Ny Annelii; Wyns Sabine; Tammela Tuomas; Haiko Paula; Karkkainen Marika J; Yuan Li; Muriel Marie-Paule; Chatzopoulou Elli; Bréant Christiane; Zalc Bernard; Carmeliet Peter; Alitalo Kari; Eichmann Anne; Thomas Jean-Léon
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.
Nature neuroscience 2006;9(3):340-8.
2006: Pätilä Tommi; Ikonen Tuija; Rutanen Juha; Ahonen Aapo; Lommi Jyri; Lappalainen Kimmo; Krogerus Leena; Ihlberg Leo; Partanen Taina A; Lähteenoja Liisa; Virtanen Kari; Alitalo Kari; Ylä-Herttuala Seppo; Harjula Ari
Vascular endothelial growth factor C-induced collateral formation in a model of myocardial ischemia.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2006;25(2):206-13.
2006: Leppänen Pia; Kholová Ivana; Mähönen Anssi J; Airenne Kari; Koota Suvi; Mansukoski Hannu; Närväinen Johanna; Wirzenius Maria; Alhonen Leena; Jänne Juhani; Alitalo Kari; Ylä-Herttuala Seppo
Short and long-term effects of hVEGF-A(165) in Cre-activated transgenic mice.
PloS one 2006;1():e13.
2005: Roy Himadri; Bhardwaj Shalini; Babu Mohan; Jauhiainen Suvi; Herzig Karl-Heinz; Bellu Anna R; Haisma Hidde J; Carmeliet Peter; Alitalo Kari; Ylä-Herttuala Seppo
Adenovirus-mediated gene transfer of placental growth factor to perivascular tissue induces angiogenesis via upregulation of the expression of endogenous vascular endothelial growth factor-A.
Human gene therapy 2005;16(12):1422-8.
2005: Alitalo Kari; Tammela Tuomas; Petrova Tatiana V
Lymphangiogenesis in development and human disease.
Nature 2005;438(7070):946-53.
2005: Ozerdem Ugur; Alitalo Kari; Salven Petri; Li Andrew
Contribution of bone marrow-derived pericyte precursor cells to corneal vasculogenesis.
Investigative ophthalmology & visual science 2005;46(10):3502-6.
2005: Leppänen Pia; Koota Suvi; Kholová Ivana; Koponen Jonna; Fieber Christina; Eriksson Ulf; Alitalo Kari; Ylä-Herttuala Seppo
Gene transfers of vascular endothelial growth factor-A, vascular endothelial growth factor-B, vascular endothelial growth factor-C, and vascular endothelial growth factor-D have no effects on atherosclerosis in hypercholesterolemic low-density lipoprotein-receptor/apolipoprotein B48-deficient mice.
Circulation 2005;112(9):1347-52.
2005: Lin JianMin; Lalani Alshad S; Harding Thomas C; Gonzalez Melissa; Wu Wei-Wei; Luan Bo; Tu Guang Huan; Koprivnikar Kathryn; VanRoey Melinda J; He Yulong; Alitalo Kari; Jooss Karin
Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor.
Cancer research 2005;65(15):6901-9.
2005: Tammela Tuomas; Petrova Tatiana V; Alitalo Kari
Molecular lymphangiogenesis: new players.
Trends in cell biology 2005;15(8):434-41.
2005: Pajusola Katri; Künnapuu Jaana; Vuorikoski Sanna; Soronen Jarkko; André Helder; Pereira Teresa; Korpisalo Petra; Ylä-Herttuala Seppo; Poellinger Lorenz; Alitalo Kari
Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(10):1365-7.
2005: He Yulong; Rajantie Iiro; Pajusola Katri; Jeltsch Michael; Holopainen Tanja; Yla-Herttuala Seppo; Harding Thomas; Jooss Karin; Takahashi Takashi; Alitalo Kari
Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels.
Cancer research 2005;65(11):4739-46.
2005: Tammela Tuomas; Saaristo Anne; Lohela Marja; Morisada Tohru; Tornberg Jenny; Norrmén Camilla; Oike Yuichi; Pajusola Katri; Thurston Gavin; Suda Toshio; Yla-Herttuala Seppo; Alitalo Kari
Angiopoietin-1 promotes lymphatic sprouting and hyperplasia.
Blood 2005;105(12):4642-8.
2005: Morisada Tohru; Oike Yuichi; Yamada Yoshihiro; Urano Takashi; Akao Masaki; Kubota Yoshiaki; Maekawa Hiromitsu; Kimura Yoshishige; Ohmura Masako; Miyamoto Takeshi; Nozawa Shiro; Koh Gou Young; Alitalo Kari; Suda Toshio
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation.
Blood 2005;105(12):4649-56.
2005: Eichmann Anne; Makinen Taija; Alitalo Kari
Neural guidance molecules regulate vascular remodeling and vessel navigation.
Genes & development 2005;19(9):1013-21.
2005: Saharinen Pipsa; Kerkelä Katja; Ekman Niklas; Marron Marie; Brindle Nicholas; Lee Gyun Min; Augustin Hellmut; Koh Gou Young; Alitalo Kari
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2.
The Journal of cell biology 2005;169(2):239-43.
2005: Kempf Volkhard A J; Lebiedziejewski Maria; Alitalo Kari; Wälzlein Joo-Hee; Ehehalt Urs; Fiebig Jeannette; Huber Stephan; Schütt Burkhardt; Sander Christian A; Müller Steffen; Grassl Guntram; Yazdi Amir S; Brehm Bernhard; Autenrieth Ingo B
Activation of hypoxia-inducible factor-1 in bacillary angiomatosis: evidence for a role of hypoxia-inducible factor-1 in bacterial infections.
Circulation 2005;111(8):1054-62.
2005: Bhardwaj S; Roy H; Kärpänen T; He Y; Jauhiainen S; Hedman M; Alitalo K; Ylä-Herttuala S
Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries.
Gene therapy 2005;12(5):388-94.
2005: Mäkinen Taija; Adams Ralf H; Bailey John; Lu Qiang; Ziemiecki Andrew; Alitalo Kari; Klein Rüdiger; Wilkinson George A
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.
Genes & development 2005;19(3):397-410.
2005: Baluk Peter; Tammela Tuomas; Ator Erin; Lyubynska Natalya; Achen Marc G; Hicklin Daniel J; Jeltsch Michael; Petrova Tatiana V; Pytowski Bronislaw; Stacker Steven A; Ylä-Herttuala Seppo; Jackson David G; Alitalo Kari; McDonald Donald M
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation.
The Journal of clinical investigation 2005;115(2):247-57.
2005: Tammela Tuomas; Enholm Berndt; Alitalo Kari; Paavonen Karri
The biology of vascular endothelial growth factors.
Cardiovascular research 2005;65(3):550-63.
2005: Oliver Guillermo; Alitalo Kari
The lymphatic vasculature: recent progress and paradigms.
Annual review of cell and developmental biology 2005;21():457-83.
2005: Wickström Sara A; Alitalo Kari; Keski-Oja Jorma
Endostatin signaling and regulation of endothelial cell-matrix interactions.
Advances in cancer research 2005;94():197-229.
2004: Alitalo Kari; Mohla Suresh; Ruoslahti Erkki
Lymphangiogenesis and cancer: meeting report.
Cancer research 2004;64(24):9225-9.
2004: Crnic Ivana; Strittmatter Karin; Cavallaro Ugo; Kopfstein Lucie; Jussila Lotta; Alitalo Kari; Christofori Gerhard
Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesis.
Cancer research 2004;64(23):8630-8.
2004: Saaristo Anne; Tammela Tuomas; Timonen Jari; Yla-Herttuala Seppo; Tukiainen Erkki; Asko-Seljavaara Sirpa; Alitalo Kari
Vascular endothelial growth factor-C gene therapy restores lymphatic flow across incision wounds.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(14):1707-9.
2004: Uutela Marko; Wirzenius Maria; Paavonen Karri; Rajantie Iiro; He Yulong; Karpanen Terhi; Lohela Marja; Wiig Helge; Salven Petri; Pajusola Katri; Eriksson Ulf; Alitalo Kari
PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.
Blood 2004;104(10):3198-204.
2004: Nilsson Ingrid; Rolny Charlotte; Wu Yan; Pytowski Bronislaw; Hicklin Dan; Alitalo Kari; Claesson-Welsh Lena; Wennström Stefan
Vascular endothelial growth factor receptor-3 in hypoxia-induced vascular development.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(13):1507-15.
2004: Rajantie Iiro; Ilmonen Maritta; Alminaite Agne; Ozerdem Ugur; Alitalo Kari; Salven Petri
Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells.
Blood 2004;104(7):2084-6.
2004: Petrova Tatiana V; Karpanen Terhi; Norrmén Camilla; Mellor Russell; Tamakoshi Tomoki; Finegold David; Ferrell Robert; Kerjaschki Dontscho; Mortimer Peter; Ylä-Herttuala Seppo; Miura Naoyuki; Alitalo Kari
Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis.
Nature medicine 2004;10(9):974-81.
2004: Paavonen Karri; Ekman Niklas; Wirzenius Maria; Rajantie Iiro; Poutanen Matti; Alitalo Kari
Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing.
Molecular biology of the cell 2004;15(9):4226-33.
2004: Bando Hiroko; Brokelmann Maren; Toi Masakazu; Alitalo Kari; Sleeman Jonathan P; Sipos Bence; Gröne Hermann-Josef; Weich Herbert A
Immunodetection and quantification of vascular endothelial growth factor receptor-3 in human malignant tumor tissues.
International journal of cancer. Journal international du cancer 2004;111(2):184-91.
2004: Wang Hsei-Wei; Trotter Matthew W B; Lagos Dimitrios; Bourboulia Dimitra; Henderson Stephen; Mäkinen Taija; Elliman Stephen; Flanagan Adrienne M; Alitalo Kari; Boshoff Chris
Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.
Nature genetics 2004;36(7):687-93.
2004: Saharinen Pipsa; Tammela Tuomas; Karkkainen Marika J; Alitalo Kari
Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation.
Trends in immunology 2004;25(7):387-95.
2004: Stolen Craig M; Yegutkin Gennady G; Kurkijärvi Riikka; Bono Petri; Alitalo Kari; Jalkanen Sirpa
Origins of serum semicarbazide-sensitive amine oxidase.
Circulation research 2004;95(1):50-7.
2004: He Yulong; Rajantie Iiro; Ilmonen Maritta; Makinen Taija; Karkkainen Marika J; Haiko Paula; Salven Petri; Alitalo Kari
Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis.
Cancer research 2004;64(11):3737-40.
2004: Gruchala Marcin; Bhardwaj Shalini; Pajusola Katri; Roy Himadri; Rissanen Tuomas T; Kokina Ilze; Kholová Ivana; Markkanen Johanna E; Rutanen Juha; Heikura Tommi; Alitalo Kari; Büeler Hansruedi; Ylä-Herttuala Seppo
Gene transfer into rabbit arteries with adeno-associated virus and adenovirus vectors.
The journal of gene medicine 2004;6(5):545-54.
2004: Wickström Sara A; Alitalo Kari; Keski-Oja Jorma
An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells.
The Journal of biological chemistry 2004;279(19):20178-85.
2004: He Yulong; Karpanen Terhi; Alitalo Kari
Role of lymphangiogenic factors in tumor metastasis.
Biochimica et biophysica acta 2004;1654(1):3-12.
2004: Leppänen Olli; Rutanen Juha; Hiltunen Mikko O; Rissanen Tuomas T; Turunen Mikko P; Sjöblom Tobias; Brüggen Josef; Bäckström Gudrun; Carlsson Marianne; Buchdunger Elisabeth; Bergqvist David; Alitalo Kari; Heldin Carl-Henrik; Ostman Arne; Ylä-Herttuala Seppo
Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits.
Circulation 2004;109(9):1140-6.
2004: Cao Renhai; Eriksson Anna; Kubo Hajime; Alitalo Kari; Cao Yihai; Thyberg Johan
Comparative evaluation of FGF-2-, VEGF-A-, and VEGF-C-induced angiogenesis, lymphangiogenesis, vascular fenestrations, and permeability.
Circulation research 2004;94(5):664-70.
2004: Weich Herbert A; Bando Hiroko; Brokelmann Maren; Baumann Petra; Toi Masakazu; Barleon Bernhard; Alitalo Kari; Sipos Bence; Sleeman Jonathan
Quantification of vascular endothelial growth factor-C (VEGF-C) by a novel ELISA.
Journal of immunological methods 2004;285(2):145-55.
2004: Porat Rinnat M; Grunewald Myriam; Globerman Anat; Itin Ahuva; Barshtein Gregory; Alhonen Leena; Alitalo Kari; Keshet Eli
Specific induction of tie1 promoter by disturbed flow in atherosclerosis-prone vascular niches and flow-obstructing pathologies.
Circulation research 2004;94(3):394-401.
2004: Ober Elke A; Olofsson Birgitta; Mäkinen Taija; Jin Suk-Won; Shoji Wataru; Koh Gou Young; Alitalo Kari; Stainier Didier Y R
Vegfc is required for vascular development and endoderm morphogenesis in zebrafish.
EMBO reports 2004;5(1):78-84.
2004: Karkkainen Marika J; Haiko Paula; Sainio Kirsi; Partanen Juha; Taipale Jussi; Petrova Tatiana V; Jeltsch Michael; Jackson David G; Talikka Marja; Rauvala Heikki; Betsholtz Christer; Alitalo Kari
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.
Nature immunology 2004;5(1):74-80.
2003: Zhang Rong; Xu Yingqian; Ekman Niklas; Wu Zhenhua; Wu Jiong; Alitalo Kari; Min Wang
Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway.
The Journal of biological chemistry 2003;278(51):51267-76.
2003: Veikkola Tanja; Lohela Marja; Ikenberg Kristian; Mäkinen Taija; Korff Thomas; Saaristo Anne; Petrova Tatania; Jeltsch Michael; Augustin Hellmut G; Alitalo Kari
Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2006-13.
2003: Bhardwaj Shalini; Roy Himadri; Gruchala Marcin; Viita Helena; Kholova Ivana; Kokina Ilze; Achen Marc G; Stacker Steven A; Hedman Marja; Alitalo Kari; Ylä-Herttuala Seppo
Angiogenic responses of vascular endothelial growth factors in periadventitial tissue.
Human gene therapy 2003;14(15):1451-62.
2003: Rutanen Juha; Leppänen Pia; Tuomisto Tiina T; Rissanen Tuomas T; Hiltunen Mikko O; Vajanto Ismo; Niemi Mari; Häkkinen Tomi; Karkola Kari; Stacker Steven A; Achen Marc G; Alitalo Kari; Ylä-Herttuala Seppo
Vascular endothelial growth factor-D expression in human atherosclerotic lesions.
Cardiovascular research 2003;59(4):971-9.
2003: Jeltsch Michael; Tammela Tuomas; Alitalo Kari; Wilting Jörg
Genesis and pathogenesis of lymphatic vessels.
Cell and tissue research 2003;314(1):69-84.
2003: Dixelius Johan; Makinen Taija; Wirzenius Maria; Karkkainen Marika J; Wernstedt Christer; Alitalo Kari; Claesson-Welsh Lena
Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.
The Journal of biological chemistry 2003;278(42):40973-9.
2003: McColl Bradley K; Baldwin Megan E; Roufail Sally; Freeman Craig; Moritz Robert L; Simpson Richard J; Alitalo Kari; Stacker Steven A; Achen Marc G
Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D.
The Journal of experimental medicine 2003;198(6):863-8.
2003: Iivanainen Erika; Nelimarkka Lassi; Elenius Varpu; Heikkinen Satu-Maria; Junttila Teemu T; Sihombing Laura; Sundvall Maria; Maatta Jorma A; Laine V Jukka O; Yla-Herttuala Seppo; Higashiyama Shigeki; Alitalo Kari; Elenius Klaus
Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(12):1609-21.
2003: Wickström Sara A; Alitalo Kari; Keski-Oja Jorma
Endostatin associates with lipid rafts and induces reorganization of the actin cytoskeleton via down-regulation of RhoA activity.
The Journal of biological chemistry 2003;278(39):37895-901.
2003: Abassi Yama A; Rehn Marko; Ekman Niklas; Alitalo Kari; Vuori Kristiina
p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration.
The Journal of biological chemistry 2003;278(37):35636-43.
2003: Lohela Marja; Saaristo Anne; Veikkola Tanja; Alitalo Kari
Lymphangiogenic growth factors, receptors and therapies.
Thrombosis and haemostasis 2003;90(2):167-84.
2003: Hu Bo; Guo Ping; Fang Quan; Tao Huo-Quan; Wang Degui; Nagane Motoo; Huang Hui-Jein Su; Gunji Yuji; Nishikawa Ryo; Alitalo Kari; Cavenee Webster K; Cheng Shi-Yuan
Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8904-9.
2003: Wickström Sara A; Keski-Oja Jorma; Alitalo Kari
Matrix reloaded to circulation hits the tumor target.
Cancer cell 2003;3(6):513-4.
2003: Gerhardt Holger; Golding Matthew; Fruttiger Marcus; Ruhrberg Christiana; Lundkvist Andrea; Abramsson Alexandra; Jeltsch Michael; Mitchell Christopher; Alitalo Kari; Shima David; Betsholtz Christer
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia.
The Journal of cell biology 2003;161(6):1163-77.
2003: Ylä-Herttuala Seppo; Alitalo Kari
Gene transfer as a tool to induce therapeutic vascular growth.
Nature medicine 2003;9(6):694-701.
2003: Saharinen Pipsa; Alitalo Kari
Double target for tumor mass destruction.
The Journal of clinical investigation 2003;111(9):1277-80.
2003: Rissanen Tuomas T; Markkanen Johanna E; Gruchala Marcin; Heikura Tommi; Puranen Antti; Kettunen Mikko I; Kholová Ivana; Kauppinen Risto A; Achen Marc G; Stacker Steven A; Alitalo Kari; Ylä-Herttuala Seppo
VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses.
Circulation research 2003;92(10):1098-106.
2003: Tille Jean-Christophe; Wang Xueyan; Lipson Kenneth E; McMahon Gerald; Ferrara Napoleone; Zhu Zhenping; Hicklin Daniel J; Sleeman Jonathan P; Eriksson Ulf; Alitalo Kari; Pepper Michael S
Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro.
Experimental cell research 2003;285(2):286-98.
2003: Auvinen Merja; Järvinen Kristiina; Hotti Anneli; Okkeri Juha; Laitinen Jens; Jänne Olli A; Coffino Philip; Bergman Mathias; Andersson Leif C; Alitalo Kari; Hölttä Erkki
Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc.
The international journal of biochemistry & cell biology 2003;35(4):496-521.
2003: Nykänen Antti I; Krebs Rainer; Saaristo Anne; Turunen Päivi; Alitalo Kari; Ylä-Herttuala Seppo; Koskinen Petri K; Lemström Karl B
Angiopoietin-1 protects against the development of cardiac allograft arteriosclerosis.
Circulation 2003;107(9):1308-14.
2003: Kubo Hajime; Alitalo Kari
The bloody fate of endothelial stem cells.
Genes & development 2003;17(3):322-9.
2003: Salven Petri; Mustjoki Satu; Alitalo Riitta; Alitalo Kari; Rafii Shahin
VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells.
Blood 2003;101(1):168-72.
2003: Klefström Juha; Alitalo Kari
[Lentiviruses to use]
Duodecim; lääketieteellinen aikakauskirja 2003;119(20):1917-9.
2002: Saaristo Anne; Karkkainen Marika J; Alitalo Kari
Insights into the molecular pathogenesis and targeted treatment of lymphedema.
Annals of the New York Academy of Sciences 2002;979():94-110.
2002: Szuba Andrzej; Skobe Mihaela; Karkkainen Marika J; Shin William S; Beynet David P; Rockson Ned B; Dakhil Noma; Spilman Stan; Goris Michael L; Strauss H William; Quertermous Thomas; Alitalo Kari; Rockson Stanley G
Therapeutic lymphangiogenesis with human recombinant VEGF-C.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):1985-7.
2002: Shah Riyaz N H; Ibbitt J Claire; Alitalo Kari; Hurst Helen C
FGFR4 overexpression in pancreatic cancer is mediated by an intronic enhancer activated by HNF1alpha.
Oncogene 2002;21(54):8251-61.
2002: Iljin Kristina; Petrova Tatiana V; Veikkola Tanja; Kumar Vijay; Poutanen Matti; Alitalo Kari
A fluorescent Tie1 reporter allows monitoring of vascular development and endothelial cell isolation from transgenic mouse embryos.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(13):1764-74.
2002: Yuan Li; Moyon Delphine; Pardanaud Luc; Bréant Christiane; Karkkainen Marika J; Alitalo Kari; Eichmann Anne
Abnormal lymphatic vessel development in neuropilin 2 mutant mice.
Development (Cambridge, England) 2002;129(20):4797-806.
2002: Wickström Sara A; Alitalo Kari; Keski-Oja Jorma
Endostatin associates with integrin alpha5beta1 and caveolin-1, and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells.
Cancer research 2002;62(19):5580-9.
2002: Veikkola Tanja; Alitalo Kari
Dual role of Ang2 in postnatal angiogenesis and lymphangiogenesis.
Developmental cell 2002;3(3):302-4.
2002: Saaristo Anne; Veikkola Tanja; Tammela Tuomas; Enholm Berndt; Karkkainen Marika J; Pajusola Katri; Bueler Hansruedi; Ylä-Herttuala Seppo; Alitalo Kari
Lymphangiogenic gene therapy with minimal blood vascular side effects.
The Journal of experimental medicine 2002;196(6):719-30.
2002: Schoppmann Sebastian F; Birner Peter; Stöckl Johannes; Kalt Romana; Ullrich Robert; Caucig Carola; Kriehuber Ernst; Nagy Katalin; Alitalo Kari; Kerjaschki Dontscho
Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis.
The American journal of pathology 2002;161(3):947-56.
2002: Petrova Tatiana V; Mäkinen Taija; Mäkelä Tomi P; Saarela Janna; Virtanen Ismo; Ferrell Robert E; Finegold David N; Kerjaschki Dontscho; Ylä-Herttuala Seppo; Alitalo Kari
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.
The EMBO journal 2002;21(17):4593-9.
2002: Stacker Steven A; Achen Marc G; Jussila Lotta; Baldwin Megan E; Alitalo Kari
Lymphangiogenesis and cancer metastasis.
Nature reviews. Cancer 2002;2(8):573-83.
2002: Eriksson Ulf; Alitalo Kari
VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies.
Nature medicine 2002;8(8):775-7.
2002: Wilting Jörg; Papoutsi Maria; Christ Bodo; Nicolaides Kypros H; von Kaisenberg Constantin S; Borges Jörg; Stark G Björn; Alitalo Kari; Tomarev Stanislav I; Niemeyer Charlotte; Rössler Jochen
The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(10):1271-3.
2002: Cursiefen Claus; Schlötzer-Schrehardt Ursula; Küchle Michael; Sorokin Lydia; Breiteneder-Geleff Silvana; Alitalo Kari; Jackson David
Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin.
Investigative ophthalmology & visual science 2002;43(7):2127-35.
2002: Jussila Lotta; Alitalo Kari
Vascular growth factors and lymphangiogenesis.
Physiological reviews 2002;82(3):673-700.
2002: Saaristo Anne; Veikkola Tanja; Enholm Berndt; Hytönen Maija; Arola Johanna; Pajusola Katri; Turunen Païvi; Jeltsch Michael; Karkkainen Marika J; Kerjaschki Dontscho; Bueler Hansruedi; Ylä-Herttuala Seppo; Alitalo Kari
Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):1041-9.
2002: Achen Marc G; Williams Richard A; Baldwin Megan E; Lai Patricia; Roufail Sally; Alitalo Kari; Stacker Steven A
The angiogenic and lymphangiogenic factor vascular endothelial growth factor-D exhibits a paracrine mode of action in cancer.
Growth factors (Chur, Switzerland) 2002;20(2):99-107.
2002: Alitalo Kari
Growth factors controlling angiogenesis and lymphangiogenesis.
Ugeskrift for laeger 2002;164(24):3170-2.
2002: Kubo Hajime; Cao Renhai; Brakenhielm Ebba; Mäkinen Taija; Cao Yihai; Alitalo Kari
Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(13):8868-73.
2002: He Yulong; Kozaki Ken-Ichi; Karpanen Terhi; Koshikawa Katsumi; Yla-Herttuala Seppo; Takahashi Takashi; Alitalo Kari
Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling.
Journal of the National Cancer Institute 2002;94(11):819-25.
2002: Lemström Karl B; Krebs Rainer; Nykänen Antti I; Tikkanen Jussi M; Sihvola Roope K; Aaltola Eva M; Häyry Pekka J; Wood Jeanette; Alitalo Kari; Ylä-Herttuala Seppo; Koskinen Petri K
Vascular endothelial growth factor enhances cardiac allograft arteriosclerosis.
Circulation 2002;105(21):2524-30.
2002: Marchetti Sandrine; Gimond Clotilde; Iljin Kristiina; Bourcier Christine; Alitalo Kari; Pouysségur Jacques; Pagès Gilles
Endothelial cells genetically selected from differentiating mouse embryonic stem cells incorporate at sites of neovascularization in vivo.
Journal of cell science 2002;115(Pt 10):2075-85.
2002: Alitalo Kari; Carmeliet Peter
Molecular mechanisms of lymphangiogenesis in health and disease.
Cancer cell 2002;1(3):219-27.
2002: Mattila Mirjami M-T; Ruohola Johanna K; Karpanen Terhi; Jackson David G; Alitalo Kari; Härkönen Pirkko L
VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors.
International journal of cancer. Journal international du cancer 2002;98(6):946-51.
2002: Zhou Yan; McMaster Michael; Woo Kirstin; Janatpour Mary; Perry Jean; Karpanen Terhi; Alitalo Kari; Damsky Caroline; Fisher Susan J
Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome.
The American journal of pathology 2002;160(4):1405-23.
2002: Dias Sergio; Choy Margaret; Alitalo Kari; Rafii Shahin
Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy.
Blood 2002;99(6):2179-84.
2002: Witmer Antonella N; Blaauwgeers Harriet G; Weich Herbert A; Alitalo Kari; Vrensen Gijs F J M; Schlingemann Reinier O
Altered expression patterns of VEGF receptors in human diabetic retina and in experimental VEGF-induced retinopathy in monkey.
Investigative ophthalmology & visual science 2002;43(3):849-57.
2002: Karkkainen Marika J; Alitalo Kari
Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis.
Seminars in cell & developmental biology 2002;13(1):9-18.
2002: Paavonen Karri; Mandelin Jami; Partanen Taina; Jussila Lotta; Li Tian-Fang; Ristimaki Ari; Alitalo Kari; Konttinen Yrjö T
Vascular endothelial growth factors C and D and their VEGFR-2 and 3 receptors in blood and lymphatic vessels in healthy and arthritic synovium.
The Journal of rheumatology 2002;29(1):39-45.
2002: Karkkainen Marika J; Mäkinen Taija; Alitalo Kari
Lymphatic endothelium: a new frontier of metastasis research.
Nature cell biology 2002;4(1):E2-5.
2002: Mäkinen T; Alitalo K
Molecular mechanisms of lymphangiogenesis.
Cold Spring Harbor symposia on quantitative biology 2002;67():189-96.
2001: Heino T I; Kärpänen T; Wahlström G; Pulkkinen M; Eriksson U; Alitalo K; Roos C
The Drosophila VEGF receptor homolog is expressed in hemocytes.
Mechanisms of development 2001;109(1):69-77.
2001: Baldwin M E; Roufail S; Halford M M; Alitalo K; Stacker S A; Achen M G
Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis.
The Journal of biological chemistry 2001;276(47):44307-14.
2001: Karkkainen M J; Saaristo A; Jussila L; Karila K A; Lawrence E C; Pajusola K; Bueler H; Eichmann A; Kauppinen R; Kettunen M I; Yla-Herttuala S; Finegold D N; Ferrell R E; Alitalo K
A model for gene therapy of human hereditary lymphedema.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12677-82.
2001: Karpanen T; Alitalo K
Lymphatic vessels as targets of tumor therapy?
The Journal of experimental medicine 2001;194(6):F37-42.
2001: Kempf V A; Volkmann B; Schaller M; Sander C A; Alitalo K; Riess T; Autenrieth I B
Evidence of a leading role for VEGF in Bartonella henselae-induced endothelial cell proliferations.
Cellular microbiology 2001;3(9):623-32.
2001: Skobe M; Hamberg L M; Hawighorst T; Schirner M; Wolf G L; Alitalo K; Detmar M
Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma.
The American journal of pathology 2001;159(3):893-903.
2001: Mäkinen T; Veikkola T; Mustjoki S; Karpanen T; Catimel B; Nice E C; Wise L; Mercer A; Kowalski H; Kerjaschki D; Stacker S A; Achen M G; Alitalo K
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3.
The EMBO journal 2001;20(17):4762-73.
2001: Wickström S A; Veikkola T; Rehn M; Pihlajaniemi T; Alitalo K; Keski-Oja J
Endostatin-induced modulation of plasminogen activation with concomitant loss of focal adhesions and actin stress fibers in cultured human endothelial cells.
Cancer research 2001;61(17):6511-6.
2001: Ylikorkala A; Rossi D J; Korsisaari N; Luukko K; Alitalo K; Henkemeyer M; Mäkelä T P
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice.
Science (New York, N.Y.) 2001;293(5533):1323-6.
2001: Aase K; von Euler G; Li X; Pontén A; Thorén P; Cao R; Cao Y; Olofsson B; Gebre-Medhin S; Pekny M; Alitalo K; Betsholtz C; Eriksson U
Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect.
Circulation 2001;104(3):358-64.
2001: Rajantie I; Ekman N; Iljin K; Arighi E; Gunji Y; Kaukonen J; Palotie A; Dewerchin M; Carmeliet P; Alitalo K
Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium.
Molecular and cellular biology 2001;21(14):4647-55.
2001: Baldwin M E; Catimel B; Nice E C; Roufail S; Hall N E; Stenvers K L; Karkkainen M J; Alitalo K; Stacker S A; Achen M G
The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man.
The Journal of biological chemistry 2001;276(22):19166-71.
2001: Uutela M; Laurén J; Bergsten E; Li X; Horelli-Kuitunen N; Eriksson U; Alitalo K
Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFD genes.
Circulation 2001;103(18):2242-7.
2001: Bergsten E; Uutela M; Li X; Pietras K; Ostman A; Heldin C H; Alitalo K; Eriksson U
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor.
Nature cell biology 2001;3(5):512-6.
2001: Iljin K; Karkkainen M J; Lawrence E C; Kimak M A; Uutela M; Taipale J; Pajusola K; Alhonen L; Halmekytö M; Finegold D N; Ferrell R E; Alitalo K
VEGFR3 gene structure, regulatory region, and sequence polymorphisms.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(6):1028-36.
2001: Jones N; Iljin K; Dumont D J; Alitalo K
Tie receptors: new modulators of angiogenic and lymphangiogenic responses.
Nature reviews. Molecular cell biology 2001;2(4):257-67.
2001: Enholm B; Karpanen T; Jeltsch M; Kubo H; Stenback F; Prevo R; Jackson D G; Yla-Herttuala S; Alitalo K
Adenoviral expression of vascular endothelial growth factor-C induces lymphangiogenesis in the skin.
Circulation research 2001;88(6):623-9.
2001: Karpanen T; Egeblad M; Karkkainen M J; Kubo H; Ylä-Herttuala S; Jäättelä M; Alitalo K
Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth.
Cancer research 2001;61(5):1786-90.
2001: Veikkola T; Jussila L; Makinen T; Karpanen T; Jeltsch M; Petrova T V; Kubo H; Thurston G; McDonald D M; Achen M G; Stacker S A; Alitalo K
Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice.
The EMBO journal 2001;20(6):1223-31.
2001: Mandriota S J; Jussila L; Jeltsch M; Compagni A; Baetens D; Prevo R; Banerji S; Huarte J; Montesano R; Jackson D G; Orci L; Alitalo K; Christofori G; Pepper M S
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis.
The EMBO journal 2001;20(4):672-82.
2001: Mäkinen T; Jussila L; Veikkola T; Karpanen T; Kettunen M I; Pulkkanen K J; Kauppinen R; Jackson D G; Kubo H; Nishikawa S; Ylä-Herttuala S; Alitalo K
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3.
Nature medicine 2001;7(2):199-205.
2001: Skobe M; Hawighorst T; Jackson D G; Prevo R; Janes L; Velasco P; Riccardi L; Alitalo K; Claffey K; Detmar M
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis.
Nature medicine 2001;7(2):192-8.
2001: Teichert-Kuliszewska K; Maisonpierre P C; Jones N; Campbell A I; Master Z; Bendeck M P; Alitalo K; Dumont D J; Yancopoulos G D; Stewart D J
Biological action of angiopoietin-2 in a fibrin matrix model of angiogenesis is associated with activation of Tie2.
Cardiovascular research 2001;49(3):659-70.
2001: Karkkainen M J; Jussila L; Ferrell R E; Finegold D N; Alitalo K
Molecular regulation of lymphangiogenesis and targets for tissue oedema.
Trends in molecular medicine 2001;7(1):18-22.
2001: Rehn M; Veikkola T; Kukk-Valdre E; Nakamura H; Ilmonen M; Lombardo C; Pihlajaniemi T; Alitalo K; Vuori K
Interaction of endostatin with integrins implicated in angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(3):1024-9.
2001: Koolwijk P; Peters E; van der Vecht B; Hornig C; Weich H A; Alitalo K; Hicklin D J; Wu Y; Witte L; van Hinsbergh V W
Involvement of VEGFR-2 (kdr/flk-1) but not VEGFR-1 (flt-1) in VEGF-A and VEGF-C-induced tube formation by human microvascular endothelial cells in fibrin matrices in vitro.
Angiogenesis 2001;4(1):53-60.
2000: Saaristo A; Karpanen T; Alitalo K
Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis.
Oncogene 2000;19(53):6122-9.
2000: Hamada K; Oike Y; Takakura N; Ito Y; Jussila L; Dumont D J; Alitalo K; Suda T
VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis.
Blood 2000;96(12):3793-800.
2000: Hiltunen M O; Laitinen M; Turunen M P; Jeltsch M; Hartikainen J; Rissanen T T; Laukkanen J; Niemi M; Kossila M; Häkkinen T P; Kivelä A; Enholm B; Mansukoski H; Turunen A M; Alitalo K; Ylä-Herttuala S
Intravascular adenovirus-mediated VEGF-C gene transfer reduces neointima formation in balloon-denuded rabbit aorta.
Circulation 2000;102(18):2262-8.
2000: Partanen T A; Arola J; Saaristo A; Jussila L; Ora A; Miettinen M; Stacker S A; Achen M G; Alitalo K
VEGF-C and VEGF-D expression in neuroendocrine cells and their receptor, VEGFR-3, in fenestrated blood vessels in human tissues.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(13):2087-96.
2000: Wilting J; Schneider M; Papoutski M; Alitalo K; Christ B
An avian model for studies of embryonic lymphangiogenesis.
Lymphology 2000;33(3):81-94.
2000: Leu A J; Berk D A; Lymboussaki A; Alitalo K; Jain R K
Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.
Cancer research 2000;60(16):4324-7.
2000: Ekman N; Arighi E; Rajantie I; Saharinen P; Ristimäki A; Silvennoinen O; Alitalo K
The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner.
Oncogene 2000;19(36):4151-8.
2000: Saaristo A; Partanen T A; Arola J; Jussila L; Hytönen M; Mäkitie A; Vento S; Kaipainen A; Malmberg H; Alitalo K
Vascular endothelial growth factor-C and its receptor VEGFR-3 in the nasal mucosa and in nasopharyngeal tumors.
The American journal of pathology 2000;157(1):7-14.
2000: Karkkainen M J; Ferrell R E; Lawrence E C; Kimak M A; Levinson K L; McTigue M A; Alitalo K; Finegold D N
Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema.
Nature genetics 2000;25(2):153-9.
2000: Li X; Pontén A; Aase K; Karlsson L; Abramsson A; Uutela M; Bäckström G; Hellström M; Boström H; Li H; Soriano P; Betsholtz C; Heldin C H; Alitalo K; Ostman A; Eriksson U
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
Nature cell biology 2000;2(5):302-9.
2000: Paavonen K; Puolakkainen P; Jussila L; Jahkola T; Alitalo K
Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing.
The American journal of pathology 2000;156(5):1499-504.
2000: Achen M G; Roufail S; Domagala T; Catimel B; Nice E C; Geleick D M; Murphy R; Scott A M; Caesar C; Makinen T; Alitalo K; Stacker S A
Monoclonal antibodies to vascular endothelial growth factor-D block its interactions with both VEGF receptor-2 and VEGF receptor-3.
European journal of biochemistry / FEBS 2000;267(9):2505-15.
2000: Loo B B; Darwish K K; Vainikka S S; Saarikettu J J; Vihko P P; Hermonen J J; Goldman A A; Alitalo K K; Jalkanen M M
Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4.
The international journal of biochemistry & cell biology 2000;32(5):489-97.
2000: Vuorela P; Helske S; Hornig C; Alitalo K; Weich H; Halmesmäki E
Amniotic fluid--soluble vascular endothelial growth factor receptor-1 in preeclampsia.
Obstetrics and gynecology 2000;95(3):353-7.
2000: Eichmann A; Yuan L; Bréant C; Alitalo K; Koskinen P J
Developmental expression of pim kinases suggests functions also outside of the hematopoietic system.
Oncogene 2000;19(9):1215-24.
2000: Veikkola T; Karkkainen M; Claesson-Welsh L; Alitalo K
Regulation of angiogenesis via vascular endothelial growth factor receptors.
Cancer research 2000;60(2):203-12.
2000: Lymboussaki A; Achen M G; Stacker S A; Alitalo K
Growth factors regulating lymphatic vessels.
Current topics in microbiology and immunology 2000;251():75-82.
1999: Skobe M; Brown L F; Tognazzi K; Ganju R K; Dezube B J; Alitalo K; Detmar M
Vascular endothelial growth factor-C (VEGF-C) and its receptors KDR and flt-4 are expressed in AIDS-associated Kaposi's sarcoma.
The Journal of investigative dermatology 1999;113(6):1047-53.
1999: Partanen T A; Alitalo K; Miettinen M
Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors.
Cancer 1999;86(11):2406-12.
1999: Petrova T V; Makinen T; Alitalo K
Signaling via vascular endothelial growth factor receptors.
Experimental cell research 1999;253(1):117-30.
1999: Lymboussaki A; Olofsson B; Eriksson U; Alitalo K
Vascular endothelial growth factor (VEGF) and VEGF-C show overlapping binding sites in embryonic endothelia and distinct sites in differentiated adult endothelia.
Circulation research 1999;85(11):992-9.
1999: Stacker S A; Stenvers K; Caesar C; Vitali A; Domagala T; Nice E; Roufail S; Simpson R J; Moritz R; Karpanen T; Alitalo K; Achen M G
Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers.
The Journal of biological chemistry 1999;274(45):32127-36.
1999: Jones N; Master Z; Jones J; Bouchard D; Gunji Y; Sasaki H; Daly R; Alitalo K; Dumont D J
Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
The Journal of biological chemistry 1999;274(43):30896-905.
1999: Partanen T A; Makinen T; Arola J; Suda T; Weich H A; Alitalo K
Endothelial growth factor receptors in human fetal heart.
Circulation 1999;100(6):583-6.
1999: Blaauwgeers H G; Holtkamp G M; Rutten H; Witmer A N; Koolwijk P; Partanen T A; Alitalo K; Kroon M E; Kijlstra A; van Hinsbergh V W; Schlingemann R O
Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation.
The American journal of pathology 1999;155(2):421-8.
1999: Makinen T; Olofsson B; Karpanen T; Hellman U; Soker S; Klagsbrun M; Eriksson U; Alitalo K
Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1.
The Journal of biological chemistry 1999;274(30):21217-22.
1999: Veikkola T; Alitalo K
VEGFs, receptors and angiogenesis.
Seminars in cancer biology 1999;9(3):211-20.
1999: Aase K; Lymboussaki A; Kaipainen A; Olofsson B; Alitalo K; Eriksson U
Localization of VEGF-B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature.
Developmental dynamics : an official publication of the American Association of Anatomists 1999;215(1):12-25.
1999: Valtola R; Salven P; Heikkilä P; Taipale J; Joensuu H; Rehn M; Pihlajaniemi T; Weich H; deWaal R; Alitalo K
VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer.
The American journal of pathology 1999;154(5):1381-90.
1999: Vuorela-Vepsäläinen P; Alfthan H; Orpana A; Alitalo K; Stenman U H; Halmesmäki E
Vascular endothelial growth factor is bound in amniotic fluid and maternal serum.
Human reproduction (Oxford, England) 1999;14(5):1346-51.
1999: Klefstrom J; Kovanen P E; Somersalo K; Hueber A O; Littlewood T; Evan G I; Greenberg A H; Saksela E; Timonen T; Alitalo K
c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors.
Oncogene 1999;18(13):2181-8.
1999: Ruohola J K; Valve E M; Karkkainen M J; Joukov V; Alitalo K; Härkönen P L
Vascular endothelial growth factors are differentially regulated by steroid hormones and antiestrogens in breast cancer cells.
Molecular and cellular endocrinology 1999;149(1-2):29-40.
1999: Wise L M; Veikkola T; Mercer A A; Savory L J; Fleming S B; Caesar C; Vitali A; Makinen T; Alitalo K; Stacker S A
Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3071-6.
1999: Weninger W; Partanen T A; Breiteneder-Geleff S; Mayer C; Kowalski H; Mildner M; Pammer J; Stürzl M; Kerjaschki D; Alitalo K; Tschachler E
Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells.
Laboratory investigation; a journal of technical methods and pathology 1999;79(2):243-51.
1999: Breiteneder-Geleff S; Soleiman A; Kowalski H; Horvat R; Amann G; Kriehuber E; Diem K; Weninger W; Tschachler E; Alitalo K; Kerjaschki D
Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium.
The American journal of pathology 1999;154(2):385-94.
1999: Iljin K; Dube A; Kontusaari S; Korhonen J; Lahtinen I; Oettgen P; Alitalo K
Role of ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(2):377-86.
1999: Korpelainen E I; Kärkkäinen M; Gunji Y; Vikkula M; Alitalo K
Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response.
Oncogene 1999;18(1):1-8.
1999: Taipale J; Makinen T; Arighi E; Kukk E; Karkkainen M; Alitalo K
Vascular endothelial growth factor receptor-3.
Current topics in microbiology and immunology 1999;237():85-96.
1999: Eriksson U; Alitalo K
Structure, expression and receptor-binding properties of novel vascular endothelial growth factors.
Current topics in microbiology and immunology 1999;237():41-57.
1998: Korpelainen E I; Karkkainen M J; Tenhunen A; Lakso M; Rauvala H; Vierula M; Parvinen M; Alitalo K
Overexpression of VEGF in testis and epididymis causes infertility in transgenic mice: evidence for nonendothelial targets for VEGF.
The Journal of cell biology 1998;143(6):1705-12.
1998: Pepper M S; Mandriota S J; Jeltsch M; Kumar V; Alitalo K
Vascular endothelial growth factor (VEGF)-C synergizes with basic fibroblast growth factor and VEGF in the induction of angiogenesis in vitro and alters endothelial cell extracellular proteolytic activity.
Journal of cellular physiology 1998;177(3):439-52.
1998: Laurén J; Gunji Y; Alitalo K
Is angiopoietin-2 necessary for the initiation of tumor angiogenesis?
The American journal of pathology 1998;153(5):1333-9.
1998: Enholm B; Jussila L; Karkkainen M; Alitalo K
Vascular endothelial growth factor-C: a growth factor for lymphatic and blood vascular endothelial cells.
Trends in cardiovascular medicine 1998;8(7):292-7.
1998: Dumont D J; Jussila L; Taipale J; Lymboussaki A; Mustonen T; Pajusola K; Breitman M; Alitalo K
Cardiovascular failure in mouse embryos deficient in VEGF receptor-3.
Science (New York, N.Y.) 1998;282(5390):946-9.
1998: Olofsson B; Korpelainen E; Pepper M S; Mandriota S J; Aase K; Kumar V; Gunji Y; Jeltsch M M; Shibuya M; Alitalo K; Eriksson U
Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11709-14.
1998: Lymboussaki A; Partanen T A; Olofsson B; Thomas-Crusells J; Fletcher C D; de Waal R M; Kaipainen A; Alitalo K
Expression of the vascular endothelial growth factor C receptor VEGFR-3 in lymphatic endothelium of the skin and in vascular tumors.
The American journal of pathology 1998;153(2):395-403.
1998: Vuorela P; Matikainen M T; Kuusela P; Ylikorkala O; Alitalo K; Halmesmäki E
Endothelial tie receptor antigen in maternal and cord blood of healthy and preeclamptic subjects.
Obstetrics and gynecology 1998;92(2):179-83.
1998: Wartiovaara U; Salven P; Mikkola H; Lassila R; Kaukonen J; Joukov V; Orpana A; Ristimäki A; Heikinheimo M; Joensuu H; Alitalo K; Palotie A
Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation.
Thrombosis and haemostasis 1998;80(1):171-5.
1998: Salven P; Lymboussaki A; Heikkilä P; Jääskela-Saari H; Enholm B; Aase K; von Euler G; Eriksson U; Alitalo K; Joensuu H
Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors.
The American journal of pathology 1998;153(1):103-8.
1998: Jussila L; Valtola R; Partanen T A; Salven P; Heikkilä P; Matikainen M T; Renkonen R; Kaipainen A; Detmar M; Tschachler E; Alitalo R; Alitalo K
Lymphatic endothelium and Kaposi's sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3.
Cancer research 1998;58(8):1599-604.
1998: Korpelainen E I; Alitalo K
Signaling angiogenesis and lymphangiogenesis.
Current opinion in cell biology 1998;10(2):159-64.
1998: Ristimäki A; Narko K; Enholm B; Joukov V; Alitalo K
Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C.
The Journal of biological chemistry 1998;273(14):8413-8.
1998: Kinnula V L; Aito H; Klefstrom J; Alitalo K; Raivio K O
Similarities between TNF and exogenous oxidants on the cytotoxic response of c-Myc-expressing fibroblasts in vitro.
Cancer letters 1998;125(1-2):191-8.
1998: Joukov V; Kumar V; Sorsa T; Arighi E; Weich H; Saksela O; Alitalo K
A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities.
The Journal of biological chemistry 1998;273(12):6599-602.
1998: Eichmann A; Corbel C; Jaffredo T; Bréant C; Joukov V; Kumar V; Alitalo K; le Douarin N M
Avian VEGF-C: cloning, embryonic expression pattern and stimulation of the differentiation of VEGFR2-expressing endothelial cell precursors.
Development (Cambridge, England) 1998;125(4):743-52.
1998: Achen M G; Jeltsch M; Kukk E; Mäkinen T; Vitali A; Wilks A F; Alitalo K; Stacker S A
Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4).
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):548-53.
1998: Jussila L; Alitalo K; Kaipainen A
[The biology of lymphatic vessels - new findings ]
Duodecim; lääketieteellinen aikakauskirja 1998;114(4):343-8.
1997: Klefstrom J; Arighi E; Littlewood T; Jäättelä M; Saksela E; Evan G I; Alitalo K
Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappaB activation.
The EMBO journal 1997;16(24):7382-92.
1997: Saharinen P; Ekman N; Sarvas K; Parker P; Alitalo K; Silvennoinen O
The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta.
Blood 1997;90(11):4341-53.
1997: Joukov V; Kaipainen A; Jeltsch M; Pajusola K; Olofsson B; Kumar V; Eriksson U; Alitalo K
Vascular endothelial growth factors VEGF-B and VEGF-C.
Journal of cellular physiology 1997;173(2):211-5.
1997: Chilov D; Kukk E; Taira S; Jeltsch M; Kaukonen J; Palotie A; Joukov V; Alitalo K
Genomic organization of human and mouse genes for vascular endothelial growth factor C.
The Journal of biological chemistry 1997;272(40):25176-83.
1997: Ekman N; Lymboussaki A; Västrik I; Sarvas K; Kaipainen A; Alitalo K
Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries.
Circulation 1997;96(6):1729-32.
1997: Oh S J; Jeltsch M M; Birkenhäger R; McCarthy J E; Weich H A; Christ B; Alitalo K; Wilting J
VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane.
Developmental biology 1997;188(1):96-109.
1997: Monni O; Joensuu H; Franssila K; Klefstrom J; Alitalo K; Knuutila S
BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma.
Blood 1997;90(3):1168-74.
1997: Joukov V; Sorsa T; Kumar V; Jeltsch M; Claesson-Welsh L; Cao Y; Saksela O; Kalkkinen N; Alitalo K
Proteolytic processing regulates receptor specificity and activity of VEGF-C.
The EMBO journal 1997;16(13):3898-911.
1997: Kukk E; Wartiovaara U; Gunji Y; Kaukonen J; Bühring H J; Rappold I; Matikainen M T; Vihko P; Partanen J; Palotie A; Alitalo K; Alitalo R
Analysis of Tie receptor tyrosine kinase in haemopoietic progenitor and leukaemia cells.
British journal of haematology 1997;98(1):195-203.
1997: Rappold I; Ziegler B L; Köhler I; Marchetto S; Rosnet O; Birnbaum D; Simmons P J; Zannettino A C; Hill B; Neu S; Knapp W; Alitalo R; Alitalo K; Ullrich A; Kanz L; Bühring H J
Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase.
Blood 1997;90(1):111-25.
1997: Enholm B; Paavonen K; Ristimäki A; Kumar V; Gunji Y; Klefstrom J; Kivinen L; Laiho M; Olofsson B; Joukov V; Eriksson U; Alitalo K
Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia.
Oncogene 1997;14(20):2475-83.
1997: Jeltsch M; Kaipainen A; Joukov V; Meng X; Lakso M; Rauvala H; Swartz M; Fukumura D; Jain R K; Alitalo K
Hyperplasia of lymphatic vessels in VEGF-C transgenic mice.
Science (New York, N.Y.) 1997;276(5317):1423-5.
1997: Joukov V; Vihinen M; Vainikka S; Sowadski J M; Alitalo K; Bergman M
Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure.
The Biochemical journal 1997;322 ( Pt 3)():927-35.
1997: Vuorela P; Hatva E; Lymboussaki A; Kaipainen A; Joukov V; Persico M G; Alitalo K; Halmesmäki E
Expression of vascular endothelial growth factor and placenta growth factor in human placenta.
Biology of reproduction 1997;56(2):489-94.
1996: Kukk E; Lymboussaki A; Taira S; Kaipainen A; Jeltsch M; Joukov V; Alitalo K
VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development.
Development (Cambridge, England) 1996;122(12):3829-37.
1996: Hatva E; Jääskeläinen J; Hirvonen H; Alitalo K; Haltia M
Tie endothelial cell-specific receptor tyrosine kinase is upregulated in the vasculature of arteriovenous malformations.
Journal of neuropathology and experimental neurology 1996;55(11):1124-33.
1996: Kaukonen J; Lahtinen I; Laine S; Alitalo K; Palotie A
BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias.
British journal of haematology 1996;94(3):455-60.
1996: Olofsson B; Pajusola K; von Euler G; Chilov D; Alitalo K; Eriksson U
Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform.
The Journal of biological chemistry 1996;271(32):19310-7.
1996: Salvén P; Joensuu H; Heikkilä P; Matikainen M T; Wasenius V M; Alanko A; Alitalo K
Endothelial Tie growth factor receptor provides antigenic marker for assessment of breast cancer angiogenesis.
British journal of cancer 1996;74(1):69-72.
1996: Böhling T; Hatva E; Kujala M; Claesson-Welsh L; Alitalo K; Haltia M
Expression of growth factors and growth factor receptors in capillary hemangioblastoma.
Journal of neuropathology and experimental neurology 1996;55(5):522-7.
1996: Joukov V; Pajusola K; Kaipainen A; Chilov D; Lahtinen I; Kukk E; Saksela O; Kalkkinen N; Alitalo K
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.
The EMBO journal 1996;15(7):1751.
1996: Hatva E; Böhling T; Jääskeläinen J; Persico M G; Haltia M; Alitalo K
Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas.
The American journal of pathology 1996;148(3):763-75.
1996: Paavonen K; Horelli-Kuitunen N; Chilov D; Kukk E; Pennanen S; Kallioniemi O P; Pajusola K; Olofsson B; Eriksson U; Joukov V; Palotie A; Alitalo K
Novel human vascular endothelial growth factor genes VEGF-B and VEGF-C localize to chromosomes 11q13 and 4q34, respectively.
Circulation 1996;93(6):1079-82.
1996: Olofsson B; Pajusola K; Kaipainen A; von Euler G; Joukov V; Saksela O; Orpana A; Pettersson R F; Alitalo K; Eriksson U
Vascular endothelial growth factor B, a novel growth factor for endothelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(6):2576-81.
1996: Batard P; Sansilvestri P; Scheinecker C; Knapp W; Debili N; Vainchenker W; Bühring H J; Monier M N; Kukk E; Partanen J; Matikainen M T; Alitalo R; Hatzfeld J; Alitalo K
The Tie receptor tyrosine kinase is expressed by human hematopoietic progenitor cells and by a subset of megakaryocytic cells.
Blood 1996;87(6):2212-20.
1996: Joukov V; Pajusola K; Kaipainen A; Chilov D; Lahtinen I; Kukk E; Saksela O; Kalkkinen N; Alitalo K
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.
The EMBO journal 1996;15(2):290-98.
1996: Vainikka S; Joukov V; Klint P; Alitalo K
Association of a 85-kDa serine kinase with activated fibroblast growth factor receptor-4.
The Journal of biological chemistry 1996;271(3):1270-3.
1996: Alitalo K
[Endothelial growth factor and growth factor receptor genes]
Duodecim; lääketieteellinen aikakauskirja 1996;112(4):341-4.
1995: Mäkelä T P; Hellsten E; Vesa J; Hirvonen H; Palotie A; Peltonen L; Alitalo K
The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein.
Oncogene 1995;11(12):2699-704.
1995: Heiskanen M; Hellsten E; Kallioniemi O P; Mäkelä T P; Alitalo K; Peltonen L; Palotie A
Visual mapping by fiber-FISH.
Genomics 1995;30(1):31-6.
1995: Korhonen J; Lahtinen I; Halmekytö M; Alhonen L; Jänne J; Dumont D; Alitalo K
Endothelial-specific gene expression directed by the tie gene promoter in vivo.
Blood 1995;86(5):1828-35.
1995: Laan M; Kallioniemi O P; Hellsten E; Alitalo K; Peltonen L; Palotie A
Mechanically stretched chromosomes as targets for high-resolution FISH mapping.
Genome research 1995;5(1):13-20.
1995: Västrik I; Mäkelä T P; Koskinen P J; Alitalo K
Determination of sequences responsible for the differential regulation of Myc function by delta Max and Max.
Oncogene 1995;11(3):553-60.
1995: Mustonen T; Alitalo K
Endothelial receptor tyrosine kinases involved in angiogenesis.
The Journal of cell biology 1995;129(4):895-8.
1995: Ruohola J K; Valve E M; Vainikka S; Alitalo K; Härkönen P L
Androgen and fibroblast growth factor (FGF) regulation of FGF receptors in S115 mouse mammary tumor cells.
Endocrinology 1995;136(5):2179-88.
1995: Kaipainen A; Korhonen J; Mustonen T; van Hinsbergh V W; Fang G H; Dumont D; Breitman M; Alitalo K
Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3566-70.
1995: Västrik I; Kaipainen A; Penttilä T L; Lymboussakis A; Alitalo R; Parvinen M; Alitalo K
Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro.
The Journal of cell biology 1995;128(6):1197-208.
1995: Hatva E; Kaipainen A; Mentula P; Jääskeläinen J; Paetau A; Haltia M; Alitalo K
Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors.
The American journal of pathology 1995;146(2):368-78.
1995: Bergman M; Joukov V; Virtanen I; Alitalo K
Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading.
Molecular and cellular biology 1995;15(2):711-22.
1995: Hellsten E; Vesa J; Heiskanen M; Mäkelä T P; Järvelä I; Cowell J K; Mead S; Alitalo K; Palotie A; Peltonen L
Identification of YAC clones for human chromosome 1p32 and physical mapping of the infantile neuronal ceroid lipofuscinosis (INCL) locus.
Genomics 1995;25(2):404-12.
1995: Laitinen J; Sistonen L; Alitalo K; Hölttä E
Cell transformation by c-Ha-rasVal12 oncogene is accompanied by a decrease in histone H1 zero and an increase in nucleosomal repeat length.
Journal of cellular biochemistry 1995;57(1):1-11.
1994: Kaipainen A; Vlaykova T; Hatva E; Böhling T; Jekunen A; Pyrhönen S; Alitalo K
Enhanced expression of the tie receptor tyrosine kinase mesenger RNA in the vascular endothelium of metastatic melanomas.
Cancer research 1994;54(24):6571-7.
1994: Tamagnone L; Lahtinen I; Mustonen T; Virtaneva K; Francis F; Muscatelli F; Alitalo R; Smith C I; Larsson C; Alitalo K
BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2.
Oncogene 1994;9(12):3683-8.
1994: Pajusola K; Aprelikova O; Pelicci G; Weich H; Claesson-Welsh L; Alitalo K
Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.
Oncogene 1994;9(12):3545-55.
1994: Klefstrom J; Västrik I; Saksela E; Valle J; Eilers M; Alitalo K
c-Myc induces cellular susceptibility to the cytotoxic action of TNF-alpha.
The EMBO journal 1994;13(22):5442-50.
1994: Vainikka S; Joukov V; Wennström S; Bergman M; Pelicci P G; Alitalo K
Signal transduction by fibroblast growth factor receptor-4 (FGFR-4). Comparison with FGFR-1.
The Journal of biological chemistry 1994;269(28):18320-6.
1994: Oetken C; Couture C; Bergman M; Bonnefoy-Bérard N; Williams S; Alitalo K; Burn P; Mustelin T
TCR/CD3-triggering causes increased activity of the p50csk tyrosine kinase and engagement of its SH2 domain.
Oncogene 1994;9(6):1625-31.
1994: Pertovaara L; Kaipainen A; Mustonen T; Orpana A; Ferrara N; Saksela O; Alitalo K
Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.
The Journal of biological chemistry 1994;269(9):6271-4.
1994: Koskinen P J; Västrik I; Mäkelä T P; Eisenman R N; Alitalo K
Max activity is affected by phosphorylation at two NH2-terminal sites.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(3):313-20.
1994: Korhonen J; Polvi A; Partanen J; Alitalo K
The mouse tie receptor tyrosine kinase gene: expression during embryonic angiogenesis.
Oncogene 1994;9(2):395-403.
1994: Autero M; Saharinen J; Pessa-Morikawa T; Soula-Rothhut M; Oetken C; Gassmann M; Bergman M; Alitalo K; Burn P; Gahmberg C G
Tyrosine phosphorylation of CD45 phosphotyrosine phosphatase by p50csk kinase creates a binding site for p56lck tyrosine kinase and activates the phosphatase.
Molecular and cellular biology 1994;14(2):1308-21.
1994: Västrik I; Mäkelä T P; Koskinen P J; Klefstrom J; Alitalo K
Myc protein: partners and antagonists.
Critical reviews in oncogenesis 1994;5(1):59-68.
1993: Polvi A; Armstrong E; Lai C; Lemke G; Huebner K; Spritz R A; Guida L C; Nicholls R D; Alitalo K
The human TYRO3 gene and pseudogene are located in chromosome 15q14-q25.
Gene 1993;134(2):289-93.
1993: Kaipainen A; Korhonen J; Pajusola K; Aprelikova O; Persico M G; Terman B I; Alitalo K
The related FLT4, FLT1, and KDR receptor tyrosine kinases show distinct expression patterns in human fetal endothelial cells.
The Journal of experimental medicine 1993;178(6):2077-88.
1993: Pajusola K; Aprelikova O; Armstrong E; Morris S; Alitalo K
Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts.
Oncogene 1993;8(11):2931-7.
1993: Klefstrom J; Koskinen P J; Saksela E; Jäättelä M; Bravo R; Alitalo K
A sub-set of immediate early mRNAs induced by tumor necrosis factor-alpha during cellular cytotoxic and non-cytotoxic responses.
International journal of cancer. Journal international du cancer 1993;55(4):655-9.
1993: Tamagnone L; Partanen J; Armstrong E; Lasota J; Ohgami K; Tazunoki T; LaForgia S; Huebner K; Alitalo K
The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain.
Oncogene 1993;8(7):2009-14.
1993: Koskinen P J; Mäkelä T P; Västrik I; Alitalo K
Myc amplification: regulation of myc function.
Clinica chimica acta; international journal of clinical chemistry 1993;217(1):57-62.
1993: Armstrong E; Kastury K; Aprelikova O; Bullrich F; Nezelof C; Gogusev J; Wasmuth J J; Alitalo K; Morris S; Huebner K
FLT4 receptor tyrosine kinase gene mapping to chromosome band 5q35 in relation to the t(2;5), t(5;6), and t(3;5) translocations.
Genes, chromosomes & cancer 1993;7(3):144-51.
1993: Hellsten E; Vesa J; Speer M C; Mäkelä T P; Järvelä I; Alitalo K; Ott J; Peltonen L
Refined assignment of the infantile neuronal ceroid lipofuscinosis (INCL, CLN1) locus at 1p32: incorporation of linkage disequilibrium in multipoint analysis.
Genomics 1993;16(3):720-5.
1993: Partanen J; Vainikka S; Alitalo K
Structural and functional specificity of FGF receptors.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;340(1293):297-303.
1993: Maglione D; Guerriero V; Viglietto G; Ferraro M G; Aprelikova O; Alitalo K; Del Vecchio S; Lei K J; Chou J Y; Persico M G
Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14.
Oncogene 1993;8(4):925-31.
1993: Koskinen P J; Alitalo K
Role of myc amplification and overexpression in cell growth, differentiation and death.
Seminars in cancer biology 1993;4(1):3-12.
1993: Pertovaara L; Tienari J; Vainikka S; Partanen J; Saksela O; Lehtonen E; Alitalo K
Modulation of fibroblast growth factor receptor expression and signalling during retinoic acid-induced differentiation of Tera-2 teratocarcinoma cells.
Biochemical and biophysical research communications 1993;191(1):149-56.
1993: Pertovaara L; Saksela O; Alitalo K
Enhanced bFGF gene expression in response to transforming growth factor-beta stimulation of AKR-2B cells.
Growth factors (Chur, Switzerland) 1993;9(1):81-6.
1992: Vainikka S; Partanen J; Bellosta P; Coulier F; Birnbaum D; Basilico C; Jaye M; Alitalo K
Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction.
The EMBO journal 1992;11(12):4273-80.
1992: Korhonen J; Partanen J; Armstrong E; Vaahtokari A; Elenius K; Jalkanen M; Alitalo K
Enhanced expression of the tie receptor tyrosine kinase in endothelial cells during neovascularization.
Blood 1992;80(10):2548-55.
1992: Pajusola K; Aprelikova O; Korhonen J; Kaipainen A; Pertovaara L; Alitalo R; Alitalo K
FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.
Cancer research 1992;52(20):5738-43.
1992: Mäkelä T P; Partanen J; Schwab M; Alitalo K
Plasmid pLTRpoly: a versatile high-efficiency mammalian expression vector.
Gene 1992;118(2):293-4.
1992: Bergman M; Mustelin T; Oetken C; Partanen J; Flint N A; Amrein K E; Autero M; Burn P; Alitalo K
The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.
The EMBO journal 1992;11(8):2919-24.
1992: Warrington J A; Bailey S K; Armstrong E; Aprelikova O; Alitalo K; Dolganov G M; Wilcox A S; Sikela J M; Wolfe S F; Lovett M
A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5.
Genomics 1992;13(3):803-8.
1992: Korhonen J; Partanen J; Alitalo K
Expression of FGFR-4 mRNA in developing mouse tissues.
The International journal of developmental biology 1992;36(2):323-9.
1992: Mäkelä T P; Hellsten E; Vesa J; Alitalo K; Peltonen L
An Alu variable polyA repeat polymorphism upstream of L-myc at 1p32.
Human molecular genetics 1992;1(3):217.
1992: Mäkelä T P; Saksela K; Alitalo K
Amplification and rearrangement of L-myc in human small-cell lung cancer.
Mutation research 1992;276(3):307-15.
1992: Mäkelä T P; Koskinen P J; Västrik I; Alitalo K
Alternative forms of Max as enhancers or suppressors of Myc-ras cotransformation.
Science (New York, N.Y.) 1992;256(5055):373-7.
1992: Partanen J; Armstrong E; Mäkelä T P; Korhonen J; Sandberg M; Renkonen R; Knuutila S; Huebner K; Alitalo K
A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.
Molecular and cellular biology 1992;12(4):1698-707.
1992: Mäkelä T P; Shiraishi M; Borrello M G; Sekiya T; Alitalo K
Rearrangement and co-amplification of L-myc and rlf in primary lung cancer.
Oncogene 1992;7(3):405-9.
1992: Saksela K; Mäkelä T P; Hughes K; Woodgett J R; Alitalo K
Activation of protein kinase C increases phosphorylation of the L-myc trans-activator domain at a GSK-3 target site.
Oncogene 1992;7(2):347-53.
1992: Lehtola L; Partanen J; Sistonen L; Korhonen J; Wärri A; Härkönen P; Clarke R; Alitalo K
Analysis of tyrosine kinase mRNAs including four FGF receptor mRNAs expressed in MCF-7 breast-cancer cells.
International journal of cancer. Journal international du cancer 1992;50(4):598-603.
1992: Aprelikova O; Pajusola K; Partanen J; Armstrong E; Alitalo R; Bailey S K; McMahon J; Wasmuth J; Huebner K; Alitalo K
FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter.
Cancer research 1992;52(3):746-8.
1992: Armstrong E; Partanen J; Cannizzaro L; Huebner K; Alitalo K
Localization of the fibroblast growth factor receptor-4 gene to chromosome region 5q33-qter.
Genes, chromosomes & cancer 1992;4(1):94-8.
1992: Armstrong E; Cannizzaro L; Bergman M; Huebner K; Alitalo K
The c-src tyrosine kinase (CSK) gene, a potential antioncogene, localizes to human chromosome region 15q23----q25.
Cytogenetics and cell genetics 1992;60(2):119-20.
1992: Lehtola L; Lehväslaiho H; Koskinen P; Alitalo K
A chimeric EGFR/neu receptor in studies of neu function.
Cancer treatment and research 1992;61():213-28.
1992: Lehtola L; Lehväslaiho H; Koskinen P; Alitalo K
A chimeric EGFR/neu receptor in functional analysis of the neu oncoprotein.
Acta oncologica (Stockholm, Sweden) 1992;31(2):147-50.
1992: Partanen J; Vainikka S; Korhonen J; Armstrong E; Alitalo K
Diverse receptors for fibroblast growth factors.
Progress in growth factor research 1992;4(1):69-83.
1992: Korhonen J; Partanen J; Eerola E; Vainikka S; Alitalo R; Mäkelä T P; Sandberg M; Hirvonen H; Alitalo K
Five FGF receptors with distinct expression patterns.
EXS 1992;61():91-100.
1991: Partanen J; Armstrong E; Bergman M; Mäkelä T P; Hirvonen H; Huebner K; Alitalo K
cyl encodes a putative cytoplasmic tyrosine kinase lacking the conserved tyrosine autophosphorylation site (Y416src).
Oncogene 1991;6(11):2013-8.
1991: Armstrong E; Hästbacka J; Partanen J; Huebner K; Alitalo K
RFLPs in the fibroblast growth factor receptor-4 locus (FGFR4) in 5q33-qter.
Nucleic acids research 1991;19(18):5096.
1991: Lehtola L; Nistér M; Hölttä E; Westermark B; Alitalo K
Down-regulation of cellular platelet-derived growth factor receptors induced by an activated neu receptor tyrosine kinase.
Cell regulation 1991;2(8):651-61.
1991: Mäkelä T P; Kere J; Winqvist R; Alitalo K
Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer.
Molecular and cellular biology 1991;11(8):4015-21.
1991: Mäkelä T P; Saksela K; Evan G; Alitalo K
A fusion protein formed by L-myc and a novel gene in SCLC.
The EMBO journal 1991;10(6):1331-5.
1991: Partanen J; Mäkelä T P; Eerola E; Korhonen J; Hirvonen H; Claesson-Welsh L; Alitalo K
FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.
The EMBO journal 1991;10(6):1347-54.
1991: Koskinen P J; Sistonen L; Evan G; Morimoto R; Alitalo K
Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells.
Journal of virology 1991;65(2):842-51.
1991: Lehtola L; Sistonen L; Koskinen P; Lehväslaiho H; Di Renzo M F; Comoglio P M; Alitalo K
Constitutively activated neu oncoprotein tyrosine kinase interferes with growth factor-induced signals for gene activation.
Journal of cellular biochemistry 1991;45(1):69-81.
1991: Saksela K; Koskinen P J; Alitalo K
Binding of a nuclear factor to the upstream region of the c-myc gene.
Oncogene research 1991;6(1):73-6.
1991: Koskinen P J; Sistonen L; Bravo R; Alitalo K
Immediate early gene responses of NIH 3T3 fibroblasts and NMuMG epithelial cells to TGF beta-1.
Growth factors (Chur, Switzerland) 1991;5(4):283-93.
1991: Västrik I; Mäkelä T P; Koskinen P J; Saksela K; Alitalo K
myc, max, and a novel rlf-L-myc fusion protein in small-cell lung cancer.
Princess Takamatsu symposia 1991;22():307-18.
1991: Korhonen J; Partanen J; Eerola E; Vainikka S; Ilvesmäki V; Voutilainen R; Julkunen M; Mäkelä T; Alitalo K
Novel human FGF receptors with distinct expression patterns.
Annals of the New York Academy of Sciences 1991;638():403-5.
1991: Mäkelä T P; Mattson K; Alitalo K
Tumour markers and oncogenes in lung cancer.
European journal of cancer (Oxford, England : 1990) 1991;27(10):1323-7.
1990: Hirvonen H; Mäkelä T P; Sandberg M; Kalimo H; Vuorio E; Alitalo K
Expression of the myc proto-oncogenes in developing human fetal brain.
Oncogene 1990;5(12):1787-97.
1990: Partanen J; Mäkelä T P; Alitalo R; Lehväslaiho H; Alitalo K
Putative tyrosine kinases expressed in K-562 human leukemia cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(22):8913-7.
1990: Laitinen J; Sistonen L; Alitalo K; Hölttä E
c-Ha-rasVal 12 oncogene-transformed NIH-3T3 fibroblasts display more decondensed nucleosomal organization than normal fibroblasts.
The Journal of cell biology 1990;111(1):9-17.
1990: Sistonen L; Koskinen P J; Lehväslaiho H; Lehtola L; Bravo R; Alitalo K
Downregulation of the early genomic growth factor response in neu oncogene-transformed cells.
Oncogene 1990;5(6):815-21.
1990: Alitalo R; Partanen J; Pertovaara L; Hölttä E; Sistonen L; Andersson L; Alitalo K
Increased erythroid potentiating activity/tissue inhibitor of metalloproteinases and jun/fos transcription factor complex characterize tumor promoter-induced megakaryoblastic differentiation of K562 leukemia cells.
Blood 1990;75(10):1974-82.
1990: Koskinen P; Lehväslaiho H; MacDonald-Bravo H; Alitalo K; Bravo R
Similar early gene responses to ligand-activated EGFR and neu tyrosine kinases in NIH3T3 cells.
Oncogene 1990;5(4):615-8.
1990: Lehväslaiho H; Sistonen L; diRenzo F; Partanen J; Comoglio P; Hölttä E; Alitalo K
Regulation by EGF is maintained in an overexpressed chimeric EGFR/neu receptor tyrosine kinase.
Journal of cellular biochemistry 1990;42(3):123-33.
1989: Sistonen L; Hölttä E; Lehväslaiho H; Lehtola L; Alitalo K
Activation of the neu tyrosine kinase induces the fos/jun transcription factor complex, the glucose transporter and ornithine decarboxylase.
The Journal of cell biology 1989;109(5):1911-9.
1989: Saksela K; Mäkelä T P; Alitalo K
Oncogene expression in small-cell lung cancer cell lines and a testicular germ-cell tumor: activation of the N-myc gene and decreased RB mRNA.
International journal of cancer. Journal international du cancer 1989;44(1):182-5.
1989: Mäkelä T P; Saksela K; Alitalo K
Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene.
Molecular and cellular biology 1989;9(4):1545-52.
1989: Sihvola M; Sistonen L; Alitalo K; Hurme M
Mechanism of T cell proliferation in vivo: analysis of IL-2 receptor expression and activation of c-myc and c-myb oncogenes during lymphatic regeneration.
Biochemical and biophysical research communications 1989;160(1):181-8.
1989: Hurme M; Sihvola M; Alitalo K; Keski-Oja J
Transforming growth factor-beta does not alter interleukin-1 expression in cultured human macrophages.
Journal of cellular biochemistry 1989;39(4):467-75.
1989: Pertovaara L; Sistonen L; Bos T J; Vogt P K; Keski-Oja J; Alitalo K
Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation.
Molecular and cellular biology 1989;9(3):1255-62.
1989: Legraverend C; Potter A; Hölttä E; Alitalo K; Andersson L C
Interleukin-2 induces a rapid increase in ornithine decarboxylase mRNA in a cloned murine T lymphocytic cell line.
Experimental cell research 1989;181(1):273-81.
1989: Hirvonen H; Sandberg M; Kalimo H; Hukkanen V; Vuorio E; Salmi T T; Alitalo K
The N-myc proto-oncogene and IGF-II growth factor mRNAs are expressed by distinct cells in human fetal kidney and brain.
The Journal of cell biology 1989;108(3):1093-104.
1989: Sistonen L; Hölttä E; Mäkelä T P; Keski-Oja J; Alitalo K
The cellular response to induction of the p21 c-Ha-ras oncoprotein includes stimulation of jun gene expression.
The EMBO journal 1989;8(3):815-22.
1989: Lehväslaiho H; Lehtola L; Sistonen L; Alitalo K
A chimeric EGF-R-neu proto-oncogene allows EGF to regulate neu tyrosine kinase and cell transformation.
The EMBO journal 1989;8(1):159-66.
1989: Saksela K; Mäkelä T P; Evan G; Alitalo K
Rapid phosphorylation of the L-myc protein induced by phorbol ester tumor promoters and serum.
The EMBO journal 1989;8(1):149-57.
1989: Lehtola L; Lehväslaiho H; Sistonen L; Beguinot L; Alitalo K
Receptor downregulation and DNA synthesis are modulated by EGF and TPA in cells expressing an EGFR/neu chimera.
Growth factors (Chur, Switzerland) 1989;1(4):323-34.
1988: Vuorio T; Wärri A; Sandberg M; Alitalo K; Vuorio E
Expression of the c-Ha-ras and neu oncogenes in DMBA-induced, anti-estrogen-treated rat mammary tumors.
International journal of cancer. Journal international du cancer 1988;42(5):774-9.
1988: Alitalo R; Mäkelä T P; Koskinen P; Andersson L C; Alitalo K
Enhanced expression of transforming growth factor beta during megakaryoblastic differentiation of K562 leukemia cells.
Blood 1988;71(4):899-906.
1988: Hölttä E; Sistonen L; Alitalo K
The mechanisms of ornithine decarboxylase deregulation in c-Ha-ras oncogene-transformed NIH 3T3 cells.
The Journal of biological chemistry 1988;263(9):4500-7.
1988: Sandberg M; Vuorio T; Hirvonen H; Alitalo K; Vuorio E
Enhanced expression of TGF-beta and c-fos mRNAs in the growth plates of developing human long bones.
Development (Cambridge, England) 1988;102(3):461-70.
1987: Mäkelä T P; Alitalo R; Paulsson Y; Westermark B; Heldin C H; Alitalo K
Regulation of platelet-derived growth factor gene expression by transforming growth factor beta and phorbol ester in human leukemia cell lines.
Molecular and cellular biology 1987;7(10):3656-62.
1987: Alitalo K; Koskinen P; Mäkelä T P; Saksela K; Sistonen L; Winqvist R
myc oncogenes: activation and amplification.
Biochimica et biophysica acta 1987;907(1):1-32.
1987: Sistonen L; Keski-Oja J; Ulmanen I; Hölttä E; Wikgren B J; Alitalo K
Dose effects of transfected c-Ha-rasVal 12 oncogene in transformed cell clones.
Experimental cell research 1987;168(2):518-30.
1987: Alhonen-Hongisto L; Leinonen P; Sinervirta R; Laine R; Winqvist R; Alitalo K; Jänne O A; Jänne J
Mouse and human ornithine decarboxylase genes. Methylation polymorphism and amplification.
The Biochemical journal 1987;242(1):205-10.
1986: Winqvist R; Mäkelä T P; Seppänen P; Jänne O A; Alhonen-Hongisto L; Jänne J; Grzeschik K H; Alitalo K
Human ornithine decarboxylase sequences map to chromosome regions 2pter----p23 and 7cen----qter but are not coamplified with the NMYC oncogene.
Cytogenetics and cell genetics 1986;42(3):133-40.
1985: Alitalo K; Saksela K; Winqvist R; Alitalo R; Keski-Oja J; Laiho M; Ilvonen M; Knuutila S; de la Chapelle A
Acute myelogenous leukaemia with c-myc amplification and double minute chromosomes.
Lancet 1985;2(8463):1035-9.
1984: Winqvist R; Saksela K; Alitalo K
The myc proteins are not associated with chromatin in mitotic cells.
The EMBO journal 1984;3(12):2947-50.

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