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David Cohen

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TOP 3
Yuki Kawano; David E Cohen
Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease.
Valeriy Demchev; Anal Desai; Hye Won Kang; Yingxia Li; Geraldine Malana; Hamed Nayeb-Hashemi; Michele Niepel; Janis Stoll; David E Cohen; Divya Vangala; Chinweike Ukomadu
Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization.
Shuxin Han; David E Cohen
Functional characterization of thioesterase superfamily member 1/Acyl-CoA thioesterase 11: implications for metabolic regulation.

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All Publications

2013: Yuki Kawano; David E Cohen
Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease.
Journal of gastroenterology 2013;48(4):434-41.
2013: Valeriy Demchev; Anal Desai; Hye Won Kang; Yingxia Li; Geraldine Malana; Hamed Nayeb-Hashemi; Michele Niepel; Janis Stoll; David E Cohen; Divya Vangala; Chinweike Ukomadu
Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization.
PloS one 2013;8(3):e58084.
2012: Shuxin Han; David E Cohen
Functional characterization of thioesterase superfamily member 1/Acyl-CoA thioesterase 11: implications for metabolic regulation.
Journal of lipid research 2012;53(12):2620-31.
2012: Florian W Kiefer; Shriram Nallamshetty; Patrick O'Brien; Steffen Spoerl; Thomas M Stulnig; Cecile VERNOCHET; Maximilian Zeyda; Jonathan D Brown; David E Cohen; C Ronald Kahn; Jorge Plutzky
Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue.
Nature medicine 2012;18(6):918-25.
2012: Hye Won Kang; Yuki Kawano; Michele W Niepel; Shuxin Han; David E Cohen
Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates hepatic lipid and glucose metabolism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(5):2209-21.
2012: Yongzhao Zhang; Shuxin Han; Yuki Kawano; P. Reed larsen; Chih-Hao Lee; Yingxia Li; Sihao Liu; Alessandro Marsili; Michele W Niepel; David E Cohen
Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(14):5417-22.
2011: Parth Patwari; Eric E Schadt; Stephen G Young; Ann Marie Zavacki; Yongzhao Zhang; William A Chutkow; David E Cohen; Radu Dobrin; Valur Emilsson; Loren G Fong; P. Reed larsen; Samuel Lee; Alessandro Marsili; Richard T Lee
The arrestin domain-containing 3 protein regulates body mass and energy expenditure.
Cell metabolism 2011;14(5):671-83.
2011: Ekaterina Y Shishova; Sudeep Shrestha; Gregory L Stahl; Janis M Stoll; Ya Su; Gregory D Cuny; Baran A Ersoy; Marcie A Glicksman; Roger Gutierrez-Juarez; Linda Jelicks; Yingxia Li; Michele W Niepel; Erez F Scapa; David E Cohen
Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production.
Hepatology (Baltimore, Md.) 2011;54(2):664-74.
2011: David E Cohen; Dawn Fernandez; Francisco Lázaro-Diéguez; Anne Muesch
The serine/threonine kinase Par1b regulates epithelial lumen polarity via IRSp53-mediated cell-ECM signaling.
The Journal of cell biology 2011;192(3):525-40.
2010: Attilio Rigotti; David E Cohen; Silvana Zanlungo
STARTing to understand MLN64 function in cholesterol transport.
Journal of lipid research 2010;51(8):2015-7.
2010: Hye Won Kang; Jie Wei; David E Cohen
PC-TP/StARD2: Of membranes and metabolism.
Trends in endocrinology and metabolism: TEM 2010;21(7):449-56.
2010: Tamar H Taddei; James Dziura; S Chen; Ruhua Yang; Hideyuki Hyogo; Cameron Sullards; David E Cohen; Gregory Pastores; Pramod K Mistry
High incidence of cholesterol gallstone disease in type 1 Gaucher disease: characterizing the biliary phenotype of type 1 Gaucher disease.
Journal of inherited metabolic disease 2010;33(3):291-300.
2010: Hye Won Kang; Keishi Kanno; Erez F Scapa; David E Cohen
Regulatory role for phosphatidylcholine transfer protein/StarD2 in the metabolic response to peroxisome proliferator activated receptor alpha (PPARalpha).
Biochimica et biophysica acta 2010;1801(4):496-502.
2009: Hye Won Kang; Scott Ribich; Brian W. Kim; Susan J Hagen; Antonio Bianco; David E Cohen
Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue.
Journal of lipid research 2009;50(11):2212-21.
2009: Jie Wei; Hye Won Kang; David E Cohen
Thioesterase superfamily member 2 (Them2)/acyl-CoA thioesterase 13 (Acot13): a homotetrameric hotdog fold thioesterase with selectivity for long-chain fatty acyl-CoAs.
The Biochemical journal 2009;421(2):311-22.
2009: Jennifer L Estall; Mario Kahn; Marcus P Cooper; Ffolliott Martin Fisher; Michele K Wu; Dina Laznik; Lishu Qu; David E Cohen; Gerald I Shulman; Bruce M Spiegelman
Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression.
Diabetes 2009;58(7):1499-508.
2009: David Q-H Wang; David E Cohen; Martin C Carey
Biliary lipids and cholesterol gallstone disease.
Journal of lipid research 2009;50 Suppl():S406-11.
2008: Neil Wagle; Jun Xian; Ekaterina Y Shishova; Jie Wei; Marcie A Glicksman; Gregory D Cuny; Ross L Stein; David E Cohen
Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening.
Analytical biochemistry 2008;383(1):85-92.
2008: Erez F Scapa; Alessandro Pocai; Michele K Wu; Roger Gutierrez-Juarez; Lauren Glenz; Keishi Kanno; Hua Li; Sudha Biddinger; Linda Jelicks; Luciano Rossetti; David E Cohen
Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(7):2579-90.
2008: Ann-Hwee Lee; Erez F Scapa; David E Cohen; Laurie H Glimcher
Regulation of hepatic lipogenesis by the transcription factor XBP1.
Science (New York, N.Y.) 2008;320(5882):1492-6.
2008: David E Cohen
Balancing cholesterol synthesis and absorption in the gastrointestinal tract.
Journal of clinical lipidology 2008;2(2):S1-3.
2008: Clavia Ruth Wooton-Kee; David E Cohen; Mary Vore
Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat.
American journal of physiology. Gastrointestinal and liver physiology 2008;294(4):G1009-16.
2008: Sudha B Biddinger; Antonio Hernandez-Ono; Christian Rask-Madsen; Joel T Haas; José O Alemán; Ryo Suzuki; Erez F Scapa; Chhavi Agarwal; Martin C Carey; Gregory Stephanopoulos; David E Cohen; George L King; Henry N Ginsberg; C Ronald Kahn
Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.
Cell metabolism 2008;7(2):125-34.
2007: Keishi Kanno; Michele K Wu; Diana S Agate; Brandon J Fanelli; Neil Wagle; Erez F Scapa; Chinweike Ukomadu; David E Cohen
Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2.
The Journal of biological chemistry 2007;282(42):30728-36.
2007: Keishi Kanno; Michele K Wu; Erez F Scapa; Steven L Roderick; David E Cohen
Structure and function of phosphatidylcholine transfer protein (PC-TP)/StarD2.
Biochimica et biophysica acta 2007;1771(6):654-62.
2007: Ignacio Bravo; Ludwig Amigo; David E Cohen; Flavio Nervi; Attilio Rigotti; Omar L Francone; Silvana Zanlungo
Role of plasma and liver cholesterol- and lipoprotein-metabolism determinants in LpX formation in the mouse.
Biochimica et biophysica acta 2007;1770(6):979-88.
2006: Wen-Jun Wang; Juan M Baez; Rie Maurer; Hayes M Dansky; David E Cohen
Homozygous disruption of Pctp modulates atherosclerosis in apolipoprotein E-deficient mice.
Journal of lipid research 2006;47(11):2400-7.
2006: Huei-Ju Pan; Diana S Agate; Benjamin L King; Michele K Wu; Steven L Roderick; Edward H Leiter; David E Cohen
A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein.
FEBS letters 2006;580(25):5953-8.
2006: David E Cohen; Frank A Anania; Naga Chalasani
An assessment of statin safety by hepatologists.
The American journal of cardiology 2006;97(8A):77C-81C.
2005: Anne Henkel; Zhixin Wei; David E Cohen; Richard M Green
Mice overexpressing hepatic Abcb11 rapidly develop cholesterol gallstones.
Mammalian genome : official journal of the International Mammalian Genome Society 2005;16(12):903-8.
2005: Michele K Wu; David E Cohen
Phosphatidylcholine transfer protein regulates size and hepatic uptake of high-density lipoproteins.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(6):G1067-74.
2005: Michele K Wu; David E Cohen
Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(3):G456-61.
2005: Juan M Baez; Ira Tabas; David E Cohen
Decreased lipid efflux and increased susceptibility to cholesterol-induced apoptosis in macrophages lacking phosphatidylcholine transfer protein.
The Biochemical journal 2005;388(Pt 1):57-63.
2005: Suheeta Roy; Hideyuki Hyogo; Suresh K Yadav; Michele K Wu; Linda Jelicks; Joseph Locker; Philippe G Frank; Michael P Lisanti; David L Silver; David E Cohen
A biphasic response of hepatobiliary cholesterol metabolism to dietary fat at the onset of obesity in the mouse.
Hepatology (Baltimore, Md.) 2005;41(4):887-95.
2005: Michele K Wu; Hideyuki Hyogo; Suresh K Yadav; Phyllis M Novikoff; David E Cohen
Impaired response of biliary lipid secretion to a lithogenic diet in phosphatidylcholine transfer protein-deficient mice.
Journal of lipid research 2005;46(3):422-31.
2005: Sandrine Dubrac; Steven R Lear; Meenakshisundaram Ananthanarayanan; Natarajan Balasubramaniyan; Jaya Bollineni; Sarah Shefer; Hideyuki Hyogo; David E Cohen; Patricia J Blanche; Ronald M Krauss; Ashok K Batta; Gerald Salen; Frederick J Suchy; Nobuyo Maeda; Sandra K Erickson
Role of CYP27A in cholesterol and bile acid metabolism.
Journal of lipid research 2005;46(1):76-85.
2004: Junichi Shoda; Yoichi Inada; Atsutoshi Tsuji; Hiroshi Kusama; Tetsuya Ueda; Tadashi Ikegami; Hiroshi Suzuki; Yuichi Sugiyama; David E Cohen; Naomi Tanaka
Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4.
Journal of lipid research 2004;45(10):1813-25.
2004: Sonya Vanpatten; George Karkanias; Luciano Rossetti; David E Cohen
Intracerebroventricular leptin regulates hepatic cholesterol metabolism.
The Biochemical journal 2004;379(Pt 2):229-33.
2004: Anne Figge; Frank Lammert; Beverly Paigen; Anne Henkel; Siegfried Matern; Ron Korstanje; Benjamin L Shneider; Frank Chen; Erik Stoltenberg; Kathryn Spatz; Farzana Hoda; David E Cohen; Richard M Green
Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis.
The Journal of biological chemistry 2004;279(4):2790-9.
2003: David Q-H Wang; Susumu Tazuma; David E Cohen; Martin C Carey
Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(3):G494-502.
2003: Hideyuki Hyogo; Suheeta Roy; David E Cohen
Restoration of gallstone susceptibility by leptin in C57BL/6J ob/ob mice.
Journal of lipid research 2003;44(6):1232-40.
2003: Sandra K Erickson; Steven R Lear; Sean Deane; Sandrine Dubrac; Sandra L Huling; Lien Nguyen; Jaya Bollineni; Sarah Shefer; Hideyuki Hyogo; David E Cohen; Benjamin L Shneider; Ephraim Sehayek; Meenakshisundaram Ananthanarayanan; Natarajan Balasubramaniyan; Frederick J Suchy; Ashok K Batta; Gerald Salen
Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice.
Journal of lipid research 2003;44(5):1001-9.
2003: Ludwig Amigo; Silvana Zanlungo; Juan Miquel; Jane M Glick; Hideyuki Hyogo; David E Cohen; Attilio Rigotti; Flavio Nervi
Hepatic overexpression of sterol carrier protein-2 inhibits VLDL production and reciprocally enhances biliary lipid secretion.
Journal of lipid research 2003;44(2):399-407.
2003: Allan W Wolkoff; David E Cohen
Bile acid regulation of hepatic physiology: I. Hepatocyte transport of bile acids.
American journal of physiology. Gastrointestinal and liver physiology 2003;284(2):G175-9.
2002: William Schubert; Philippe G Frank; Scott E Woodman; Hideyuki Hyogo; David E Cohen; Chi-Wing Chow; Michael P Lisanti
Microvascular hyperpermeability in caveolin-1 (-/-) knock-out mice. Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice.
The Journal of biological chemistry 2002;277(42):40091-8.
2002: Hideyuki Hyogo; Suheeta Roy; Beverly Paigen; David E Cohen
Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts.
The Journal of biological chemistry 2002;277(37):34117-24.
2002: Steven L Roderick; Wayne W Chan; Diana S Agate; Laurence R Olsen; Matthew W Vetting; K R Rajashankar; David E Cohen
Structure of human phosphatidylcholine transfer protein in complex with its ligand.
Nature structural biology 2002;9(7):507-11.
2002: Hideyuki Hyogo; Susumu Tazuma; David E Cohen
Cholesterol gallstones.
Current opinion in gastroenterology 2002;18(3):366-71.
2002: Wayne W Chan; Steven L Roderick; David E Cohen
Human phosphatidylcholine transfer protein: purification, crystallization and preliminary X-ray diffraction data.
Biochimica et biophysica acta 2002;1596(1):1-5.
2002: Juan M Baez; Suzanne E Barbour; David E Cohen
Phosphatidylcholine transfer protein promotes apolipoprotein A-I-mediated lipid efflux in Chinese hamster ovary cells.
The Journal of biological chemistry 2002;277(8):6198-206.
2001: Philippe G Frank; A Pedraza; David E Cohen; Michael P Lisanti
Adenovirus-mediated expression of caveolin-1 in mouse liver increases plasma high-density lipoprotein levels.
Biochemistry 2001;40(36):10892-900.
2001: Sonya Vanpatten; N Ranginani; Sarah Shefer; Lien B Nguyen; Luciano Rossetti; David E Cohen
Impaired biliary lipid secretion in obese Zucker rats: leptin promotes hepatic cholesterol clearance.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(2):G393-404.
2001: Junichi Shoda; Koji Oda; Hiroshi Suzuki; Yuichi Sugiyama; K Ito; David E Cohen; L Feng; J Kamiya; Yuji Nimura; H Miyazaki; Masahito Kano; Yasushi Matsuzaki; Naomi Tanaka
Etiologic significance of defects in cholesterol, phospholipid, and bile acid metabolism in the liver of patients with intrahepatic calculi.
Hepatology (Baltimore, Md.) 2001;33(5):1194-205.
2001: Philippe G Frank; Ferruccio Galbiati; Daniela Volonte; Babak Razani; David E Cohen; Yves L Marcel; Michael P Lisanti
Influence of caveolin-1 on cellular cholesterol efflux mediated by high-density lipoproteins.
American journal of physiology. Cell physiology 2001;280(5):C1204-14.
2001: Pablo Mardones; Verónica Quiñones; Ludwig Amigo; M Moreno; Juan Miquel; M Schwarz; Helena E Miettinen; Bernardo L Trigatti; Monty Krieger; Sonya Vanpatten; David E Cohen; Attilio Rigotti
Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice.
Journal of lipid research 2001;42(2):170-80.
2000: L Feng; Wayne W Chan; Steven L Roderick; David E Cohen
High-level expression and mutagenesis of recombinant human phosphatidylcholine transfer protein using a synthetic gene: evidence for a C-terminal membrane binding domain.
Biochemistry 2000;39(50):15399-409.
2000: A Rigotti; David E Cohen
The Tangier disease gene encodes yet another pathophysiologically relevant atp-binding cassette protein.
Hepatology (Baltimore, Md.) 2000;31(2):538-40.
1999: David E Cohen; R M Green; M K Wu; David Beier
Cloning, tissue-specific expression, gene structure and chromosomal localization of human phosphatidylcholine transfer protein.
Biochimica et biophysica acta 1999;1447(2-3):265-70.
1999: David E Cohen
Hepatocellular transport and secretion of biliary lipids.
Current opinion in lipidology 1999;10(4):295-302.
1999: M K Wu; M O Boylan; David E Cohen
Cloning and gene structure of rat phosphatidylcholine transfer protein, Pctp.
Gene 1999;235(1-2):111-20.
1999: David Q-H Wang; F Lammert; David E Cohen; Beverly Paigen; Martin C Carey
Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis.
The American journal of physiology 1999;276(3 Pt 1):G751-60.
1999: David Q-H Wang; David E Cohen; F Lammert; Martin C Carey
No pathophysiologic relationship of soluble biliary proteins to cholesterol crystallization in human bile.
Journal of lipid research 1999;40(3):415-25.
1998: M Fuchs; F Lammert; D Q Wang; B Paigen; M C Carey; David E Cohen
Sterol carrier protein 2 participates in hypersecretion of biliary cholesterol during gallstone formation in genetically gallstone-susceptible mice.
The Biochemical journal 1998;336 ( Pt 1)():33-7.
1998: David E Cohen; George M Thurston; R A Chamberlin; George B. Benedek; Martin C Carey
Laser light scattering evidence for a common wormlike growth structure of mixed micelles in bile salt- and straight-chain detergent-phosphatidylcholine aqueous systems: relevance to the micellar structure of bile.
Biochemistry 1998;37(42):14798-814.
1998: A N Leonard; David E Cohen
Submicellar bile salts stimulate phosphatidylcholine transfer activity of sterol carrier protein 2.
Journal of lipid research 1998;39(10):1981-8.
1998: L Feng; David E Cohen
Baculovirus-mediated expression of recombinant rat phosphatidylcholine transfer protein.
Journal of lipid research 1998;39(9):1862-9.
1998: F Lammert; David E Cohen; Beverly Paigen; Martin C Carey; David Beier
The gene encoding the multispecific organic anion transporter (Cmoat) of the hepatocyte canalicular membrane maps to mouse chromosome 19.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(1):87-8.
1997: M Fuchs; Martin C Carey; David E Cohen
Evidence for an ATP-independent long-chain phosphatidylcholine translocator in hepatocyte membranes.
The American journal of physiology 1997;273(6 Pt 1):G1312-9.
1996: M Fuchs; David E Cohen
Transmembrane translocation of phosphatidylcholines and biliary lipid secretion: evidence for "flippases" in the canalicular plasma membrane.
Hepatology (Baltimore, Md.) 1996;24(6):1546-8.
1996: F E Kasmin; David E Cohen; S Batra; S A Cohen; J H Siegel
Needle-knife sphincterotomy in a tertiary referral center: efficacy and complications.
Gastrointestinal endoscopy 1996;44(1):48-53.
1996: David E Cohen
Hepatocellular transport and secretion of biliary phospholipids.
Seminars in liver disease 1996;16(2):191-200.
1995: David E Cohen; R M Green
Cloning and characterization of a cDNA encoding the specific phosphatidylcholine transfer protein from bovine liver.
Gene 1995;163(2):327-8.
1995: David E Cohen; M R Leonard
Immobilized artificial membrane chromatography: a rapid and accurate HPLC method for predicting bile salt-membrane interactions.
Journal of lipid research 1995;36(10):2251-60.
1995: M C Carey; David E Cohen
Update on physical state of bile.
The Italian journal of gastroenterology 1995;27(2):92-100.
1994: David E Cohen; M R Leonard; Martin C Carey
In vitro evidence that phospholipid secretion into bile may be coordinated intracellularly by the combined actions of bile salts and the specific phosphatidylcholine transfer protein of liver.
Biochemistry 1994;33(33):9975-80.
1994: F M Konikoff; David E Cohen; Martin C Carey
Phospholipid molecular species influence crystal habits and transition sequences of metastable intermediates during cholesterol crystallization from bile salt-rich model bile.
Journal of lipid research 1994;35(1):60-70.
1993: David E Cohen; E W Kaler; Martin C Carey
Cholesterol carriers in human bile: are "lamellae" involved?
Hepatology (Baltimore, Md.) 1993;18(6):1522-31.
1992: David E Cohen; L S Leighton; Martin C Carey
Bile salt hydrophobicity controls vesicle secretion rates and transformations in native bile.
The American journal of physiology 1992;263(3 Pt 1):G386-95.
1991: David E Cohen; Martin C Carey
Acyl chain unsaturation modulates distribution of lecithin molecular species between mixed micelles and vesicles in model bile. Implications for particle structure and metastable cholesterol solubilities.
Journal of lipid research 1991;32(8):1291-302.
1990: David E Cohen; Martin C Carey
Rapid (1 hour) high performance gel filtration chromatography resolves coexisting simple micelles, mixed micelles, and vesicles in bile.
Journal of lipid research 1990;31(11):2103-12.
1990: David E Cohen; Martin C Carey
Physical chemistry of biliary lipids during bile formation.
Hepatology (Baltimore, Md.) 1990;12(3 Pt 2):143S-147S; discussion 147S-148S.
1990: David E Cohen; M R Fisch; Martin C Carey
Principles of laser light-scattering spectroscopy: applications to the physicochemical study of model and native biles.
Hepatology (Baltimore, Md.) 1990;12(3 Pt 2):113S-121S; discussion 121S-122S.
1990: David E Cohen; M Angelico; Martin C Carey
Structural alterations in lecithin-cholesterol vesicles following interactions with monomeric and micellar bile salts: physical-chemical basis for subselection of biliary lecithin species and aggregative states of biliary lipids during bile formation.
Journal of lipid research 1990;31(1):55-70.
1989: David E Cohen; M Angelico; Martin C Carey
Quasielastic light scattering evidence for vesicular secretion of biliary lipids.
The American journal of physiology 1989;257(1 Pt 1):G1-8.