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Fredric Cohen

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Publications

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Michael Y K Leung; Fredric S Cohen
Increasing hydrophobicity of residues in an anti-HIV-1 Env peptide synergistically improves potency.
Fredric S Cohen; Olaf S Andersen
Cells on the MEND: exploring the role of lipidic forces in membrane trafficking.
Ruben M Markosyan; Fredric S Cohen
Negative potentials across biological membranes promote fusion by class II and class III viral proteins.

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All Publications

2011: Michael Y K Leung; Fredric S Cohen
Increasing hydrophobicity of residues in an anti-HIV-1 Env peptide synergistically improves potency.
Biophysical journal 2011;100(8):1960-8.
2011: Fredric S Cohen; Olaf S Andersen
Cells on the MEND: exploring the role of lipidic forces in membrane trafficking.
The Journal of general physiology 2011;137(2):133-6.
2010: Ruben M Markosyan; Fredric S Cohen
Negative potentials across biological membranes promote fusion by class II and class III viral proteins.
Molecular biology of the cell 2010;21(12):2001-12.
2009: Ruben M Markosyan; Michael Y Leung; Fredric S Cohen
The six-helix bundle of human immunodeficiency virus Env controls pore formation and enlargement and is initiated at residues proximal to the hairpin turn.
Journal of virology 2009;83(19):10048-57.
2008: Sergey A Akimov; Vadim A Frolov; Peter I Kuzmin; Joshua Zimmerberg; Yuri A Chizmadzhev; Fredric S Cohen
Domain formation in membranes caused by lipid wetting of protein.
Physical review. E, Statistical, nonlinear, and soft matter physics 2008;77(5 Pt 1):051901.
2008: Artem G Ayuyan; Fredric S Cohen
Raft composition at physiological temperature and pH in the absence of detergents.
Biophysical journal 2008;94(7):2654-66.
2007: Ruben M Markosyan; Margaret Kielian; Fredric S Cohen
Fusion induced by a class II viral fusion protein, semliki forest virus E1, is dependent on the voltage of the target cell.
Journal of virology 2007;81(20):11218-25.
2007: Sergey A Akimov; Peter I Kuzmin; Joshua Zimmerberg; Fredric S Cohen
Lateral tension increases the line tension between two domains in a lipid bilayer membrane.
Physical review. E, Statistical, nonlinear, and soft matter physics 2007;75(1 Pt 1):011919.
2006: Artem G Ayuyan; Fredric S Cohen
Lipid peroxides promote large rafts: effects of excitation of probes in fluorescence microscopy and electrochemical reactions during vesicle formation.
Biophysical journal 2006;91(6):2172-83.
2006: Vadim A Frolov; Yuri A Chizmadzhev; Fredric S Cohen; Joshua Zimmerberg
"Entropic traps" in the kinetics of phase separation in multicomponent membranes stabilize nanodomains.
Biophysical journal 2006;91(1):189-205.
2005: Ruben M Markosyan; Fredric S Cohen; Gregory Melikian
Time-resolved imaging of HIV-1 Env-mediated lipid and content mixing between a single virion and cell membrane.
Molecular biology of the cell 2005;16(12):5502-13.
2005: Samvel R Mkrtchyan; Ruben M Markosyan; Michael T Eadon; John P Moore; Gregory Melikian; Fredric S Cohen
Ternary complex formation of human immunodeficiency virus type 1 Env, CD4, and chemokine receptor captured as an intermediate of membrane fusion.
Journal of virology 2005;79(17):11161-9.
2005: Peter I Kuzmin; Sergey A Akimov; Yuri A Chizmadzhev; Joshua Zimmerberg; Fredric S Cohen
Line tension and interaction energies of membrane rafts calculated from lipid splay and tilt.
Biophysical journal 2005;88(2):1120-33.
2005: Levon Abrahamyan; Samvel R Mkrtchyan; James M Binley; Min Lu; Gregory Melikian; Fredric S Cohen
The cytoplasmic tail slows the folding of human immunodeficiency virus type 1 Env from a late prebundle configuration into the six-helix bundle.
Journal of virology 2005;79(1):106-15.
2004: Ruben M Markosyan; P Bates; Fredric S Cohen; Gregory Melikian
A study of low pH-induced refolding of Env of avian sarcoma and leukosis virus into a six-helix bundle.
Biophysical journal 2004;87(5):3291-8.
2004: Fredric S Cohen; Gregory Melikian
The energetics of membrane fusion from binding, through hemifusion, pore formation, and pore enlargement.
The Journal of membrane biology 2004;199(1):1-14.
2004: Gregory Melikian; Richard J O Barnard; Ruben M Markosyan; John A T Young; Fredric S Cohen
Low pH is required for avian sarcoma and leukosis virus Env-induced hemifusion and fusion pore formation but not for pore growth.
Journal of virology 2004;78(7):3753-62.
2003: E Borrego-Diaz; Mark Peeples; Ruben M Markosyan; Gregory Melikian; Fredric S Cohen
Completion of trimeric hairpin formation of influenza virus hemagglutinin promotes fusion pore opening and enlargement.
Virology 2003;316(2):234-44.
2003: Levon Abrahamyan; Ruben M Markosyan; J P Moore; Fredric S Cohen; Gregory Melikian
Human immunodeficiency virus type 1 Env with an intersubunit disulfide bond engages coreceptors but requires bond reduction after engagement to induce fusion.
Journal of virology 2003;77(10):5829-36.
2003: Ruben M Markosyan; Fredric S Cohen; Gregory Melikian
HIV-1 envelope proteins complete their folding into six-helix bundles immediately after fusion pore formation.
Molecular biology of the cell 2003;14(3):926-38.
2002: Andrey Samsonov; Prodyot Chatterjee; Vladimir Razinkov; Christina H Eng; Margaret Kielian; Fredric S Cohen
Effects of membrane potential and sphingolipid structures on fusion of Semliki Forest virus.
Journal of virology 2002;76(24):12691-702.
2002: Ruben M Markosyan; Xiuwen Ma; Min Lu; Fredric S Cohen; Gregory Melikian
The mechanism of inhibition of HIV-1 env-mediated cell-cell fusion by recombinant cores of gp41 ectodomain.
Virology 2002;302(1):174-84.
2001: Andrey Samsonov; I Mihalyov; Fredric S Cohen
Characterization of cholesterol-sphingomyelin domains and their dynamics in bilayer membranes.
Biophysical journal 2001;81(3):1486-500.
2001: Fredric S Cohen; Gregory Melikian
Implications of a fusion peptide structure.
Nature structural biology 2001;8(8):653-5.
2001: Peter I Kuzmin; Joshua Zimmerberg; Yuri A Chizmadzhev; Fredric S Cohen
A quantitative model for membrane fusion based on low-energy intermediates.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7235-40.
2001: Ruben M Markosyan; Gregory Melikian; Fredric S Cohen
Evolution of intermediates of influenza virus hemagglutinin-mediated fusion revealed by kinetic measurements of pore formation.
Biophysical journal 2001;80(2):812-21.
2000: Vladimir Razinkov; Fredric S Cohen
Sterols and sphingolipids strongly affect the growth of fusion pores induced by the hemagglutinin of influenza virus.
Biochemistry 2000;39(44):13462-8.
2000: Gregory Melikian; Ruben M Markosyan; Michael Roth; Fredric S Cohen
A point mutation in the transmembrane domain of the hemagglutinin of influenza virus stabilizes a hemifusion intermediate that can transit to fusion.
Molecular biology of the cell 2000;11(11):3765-75.
2000: Gregory Melikian; Ruben M Markosyan; H Hemmati; M K Delmedico; D M Lambert; Fredric S Cohen
Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion.
The Journal of cell biology 2000;151(2):413-23.
2000: Yuri A Chizmadzhev; Peter I Kuzmin; DA Kumenko; Joshua Zimmerberg; Fredric S Cohen
Dynamics of fusion pores connecting membranes of different tensions.
Biophysical journal 2000;78(5):2241-56.
2000: Ruben M Markosyan; Fredric S Cohen; Gregory Melikian
The lipid-anchored ectodomain of influenza virus hemagglutinin (GPI-HA) is capable of inducing nonenlarging fusion pores.
Molecular biology of the cell 2000;11(4):1143-52.
2000: Gregory Melikian; Ruben M Markosyan; S A Brener; Y Rozenberg; Fredric S Cohen
Role of the cytoplasmic tail of ecotropic moloney murine leukemia virus Env protein in fusion pore formation.
Journal of virology 2000;74(1):447-55.
1999: Vladimir Razinkov; Gregory Melikian; Fredric S Cohen
Hemifusion between cells expressing hemagglutinin of influenza virus and planar membranes can precede the formation of fusion pores that subsequently fully enlarge.
Biophysical journal 1999;77(6):3144-51.
1999: H Qiao; R Todd Armstrong; Gregory Melikian; Fredric S Cohen; Judith M White
A specific point mutant at position 1 of the influenza hemagglutinin fusion peptide displays a hemifusion phenotype.
Molecular biology of the cell 1999;10(8):2759-69.
1999: Ruben M Markosyan; Gregory Melikian; Fredric S Cohen
Tension of membranes expressing the hemagglutinin of influenza virus inhibits fusion.
Biophysical journal 1999;77(2):943-52.
1999: Vladimir Razinkov; I Martin; S J Turco; Fredric S Cohen; J M Ruysschaert; R M Epand
Relationship of membrane sidedness to the effects of the lipophosphoglycan of Leishmania donovani on the fusion of influenza virus.
European journal of biochemistry / FEBS 1999;262(3):890-9.
1999: Gregory Melikian; S Lin; Michael Roth; Fredric S Cohen
Amino acid sequence requirements of the transmembrane and cytoplasmic domains of influenza virus hemagglutinin for viable membrane fusion.
Molecular biology of the cell 1999;10(6):1821-36.
1999: Yuri A Chizmadzhev; DA Kumenko; Peter I Kuzmin; Leonid V Chernomordik; Joshua Zimmerberg; Fredric S Cohen
Lipid flow through fusion pores connecting membranes of different tensions.
Biophysical journal 1999;76(6):2951-65.
1998: Fredric S Cohen; Gregory Melikian
Methodologies in the study of cell-cell fusion.
Methods (San Diego, Calif.) 1998;16(2):215-26.
1998: Vladimir Razinkov; Gregory Melikian; R M Epand; R F Epand; Fredric S Cohen
Effects of spontaneous bilayer curvature on influenza virus-mediated fusion pores.
The Journal of general physiology 1998;112(4):409-22.
1997: Vladimir Razinkov; E I Hernandez-Jimenez; II Mikhalyov; Fredric S Cohen; Julian G Molotkovsky
New fluorescent lysolipids: preparation and selective labeling of inner liposome leaflet.
Biochimica et biophysica acta 1997;1329(1):149-58.
1997: Gregory Melikian; H Jin; R A Lamb; Fredric S Cohen
The role of the cytoplasmic tail region of influenza virus hemagglutinin in formation and growth of fusion pores.
Virology 1997;235(1):118-28.
1997: Gregory Melikian; S A Brener; D C Ok; Fredric S Cohen
Inner but not outer membrane leaflets control the transition from glycosylphosphatidylinositol-anchored influenza hemagglutinin-induced hemifusion to full fusion.
The Journal of cell biology 1997;136(5):995-1005.
1997: E I Hernandez-Jimenez; Vladimir Razinkov; II Mikhalyov; A V Kozminykh; Fredric S Cohen; Julian G Molotkovsky
Selective labeling of the inner liposome leaflet by fluorescent lipid probes, and studies of liposome fusion with influenza virus.
Membrane & cell biology 1997;11(4):515-27.
1996: Gregory Melikian; B N Deriy; D C Ok; Fredric S Cohen
Voltage-dependent translocation of R18 and DiI across lipid bilayers leads to fluorescence changes.
Biophysical journal 1996;71(5):2680-91.
1996: Walter Niles; J R Silvius; Fredric S Cohen
Resonance energy transfer imaging of phospholipid vesicle interaction with a planar phospholipid membrane: undulations and attachment sites in the region of calcium-mediated membrane--membrane adhesion.
The Journal of general physiology 1996;107(3):329-51.
1996: Fredric S Cohen
Voltage drives a long segment of polar residues of colicins across membranes.
The Journal of general physiology 1996;107(3):307-10.
1996: Judith M White; tsafi danieli; Yoav I Henis; Gregory Melikian; Fredric S Cohen
Membrane fusion by the influenza hemagglutinin: the fusion pore.
Society of General Physiologists series 1996;51():223-9.
1995: Gregory Melikian; Walter Niles; V A Ratinov; M Karhanek; J Zimmerberg; Fredric S Cohen
Comparison of transient and successful fusion pores connecting influenza hemagglutinin expressing cells to planar membranes.
The Journal of general physiology 1995;106(5):803-19.
1995: Gregory Melikian; Walter Niles; Fredric S Cohen
The fusion kinetics of influenza hemagglutinin expressing cells to planar bilayer membranes is affected by HA density and host cell surface.
The Journal of general physiology 1995;106(5):783-802.
1995: Gregory Melikian; Judith M White; Fredric S Cohen
GPI-anchored influenza hemagglutinin induces hemifusion to both red blood cell and planar bilayer membranes.
The Journal of cell biology 1995;131(3):679-91.
1995: William A Cramer; J Bernard Heymann; S L Schendel; B N Deriy; Fredric S Cohen; P A Elkins; Cynthia V Stauffacher
Structure-function of the channel-forming colicins.
Annual review of biophysics and biomolecular structure 1995;24():611-41.
1993: Gregory Melikian; Walter Niles; Fredric S Cohen
Influenza virus hemagglutinin-induced cell-planar bilayer fusion: quantitative dissection of fusion pore kinetics into stages.
The Journal of general physiology 1993;102(6):1151-70.
1993: Gregory Melikian; Walter Niles; Mark Peeples; Fredric S Cohen
Influenza hemagglutinin-mediated fusion pores connecting cells to planar membranes: flickering to final expansion.
The Journal of general physiology 1993;102(6):1131-49.
1993: Walter Niles; Fredric S Cohen
Single event recording shows that docking onto receptor alters the kinetics of membrane fusion mediated by influenza hemagglutinin.
Biophysical journal 1993;65(1):171-6.
1993: Fredric S Cohen; Walter Niles
Reconstituting channels into planar membranes: a conceptual framework and methods for fusing vesicles to planar bilayer phospholipid membranes.
Methods in enzymology 1993;220():50-68.
1992: Walter Niles; Q Li; Fredric S Cohen
Computer detection of the rapid diffusion of fluorescent membrane fusion markers in images observed with video microscopy.
Biophysical journal 1992;63(3):710-22.
1992: William A Cramer; Y L Zhang; S Schendel; Rod Merrill; H Y Song; Cynthia V Stauffacher; Fredric S Cohen
Dynamic properties of the colicin E1 ion channel.
FEMS microbiology immunology 1992;5(1-3):71-81.
1991: Walter Niles; Fredric S Cohen
The role of N-acetylneuraminic (sialic) acid in the pH dependence of influenza virion fusion with planar phospholipid membranes.
The Journal of general physiology 1991;97(6):1121-40.
1991: Walter Niles; Fredric S Cohen
Fusion of influenza virions with a planar lipid membrane detected by video fluorescence microscopy.
The Journal of general physiology 1991;97(6):1101-19.
1991: H Y Song; Fredric S Cohen; William A Cramer
Membrane topography of ColE1 gene products: the hydrophobic anchor of the colicin E1 channel is a helical hairpin.
Journal of bacteriology 1991;173(9):2927-34.
1991: Walter Niles; Fredric S Cohen
Video microscopy studies of vesicle-planar membrane adhesion and fusion.
Annals of the New York Academy of Sciences 1991;635():273-84.
1990: A R Merrill; Fredric S Cohen; William A Cramer
On the nature of the structural change of the colicin E1 channel peptide necessary for its translocation-competent state.
Biochemistry 1990;29(24):5829-36.
1990: William A Cramer; Fredric S Cohen; A R Merrill; H Y Song
Structure and dynamics of the colicin E1 channel.
Molecular microbiology 1990;4(4):519-26.
1990: Walter Niles; Mark Peeples; Fredric S Cohen
Kinetics of virus-induced hemolysis measured for single erythrocytes.
Virology 1990;174(2):593-8.
1989: Komei Shirabe; Fredric S Cohen; S Xu; A A Peterson; J W Shiver; A Nakazawa; William A Cramer
Decrease of anion selectivity caused by mutation of Thr501 and Gly502 to Glu in the hydrophobic domain of the colicin E1 channel.
The Journal of biological chemistry 1989;264(4):1951-7.
1989: Fredric S Cohen; Walter Niles; Myles H Akabas
Fusion of phospholipid vesicles with a planar membrane depends on the membrane permeability of the solute used to create the osmotic pressure.
The Journal of general physiology 1989;93(2):201-10.
1989: Walter Niles; Fredric S Cohen; Alan Finkelstein
Hydrostatic pressures developed by osmotically swelling vesicles bound to planar membranes.
The Journal of general physiology 1989;93(2):211-44.
1988: J W Shiver; Fredric S Cohen; A R Merrill; William A Cramer
Site-directed mutagenesis of the charged residues near the carboxy terminus of the colicin E1 ion channel.
Biochemistry 1988;27(22):8421-8.
1988: Walter Niles; R A Levis; Fredric S Cohen
Planar bilayer membranes made from phospholipid monolayers form by a thinning process.
Biophysical journal 1988;53(3):327-35.
1987: Walter Niles; Fredric S Cohen
Video fluorescence microscopy studies of phospholipid vesicle fusion with a planar phospholipid membrane. Nature of membrane-membrane interactions and detection of release of contents.
The Journal of general physiology 1987;90(5):703-35.
1987: J W Shiver; William A Cramer; Fredric S Cohen; L J Bishop; P J de Jong
On the explanation of the acidic pH requirement for in vitro activity of colicin E1. Site-directed mutagenesis at Glu-468.
The Journal of biological chemistry 1987;262(29):14273-81.
1986: L J Bishop; Fredric S Cohen; V L Davidson; W A Cramer
Chemical modification of the two histidine and single cysteine residues in the channel-forming domain of colicin E1.
The Journal of membrane biology 1986;92(3):237-45.
1984: Myles H Akabas; Fredric S Cohen; Alan Finkelstein
Separation of the osmotically driven fusion event from vesicle-planar membrane attachment in a model system for exocytosis.
The Journal of cell biology 1984;98(3):1063-71.
1984: Fredric S Cohen; Myles H Akabas; J Zimmerberg; Alan Finkelstein
Parameters affecting the fusion of unilamellar phospholipid vesicles with planar bilayer membranes.
The Journal of cell biology 1984;98(3):1054-62.
1982: Fredric S Cohen; Myles H Akabas; Alan Finkelstein
Osmotic swelling of phospholipid vesicles causes them to fuse with a planar phospholipid bilayer membrane.
Science (New York, N.Y.) 1982;217(4558):458-60.