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Gerald Cohen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Physiology

Enzyme Activation

Anatomy

Disorders

Leukemia, Lymphocytic, Chronic, B-Cell

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Co-Publications
Name
26
MacFarlane, Marion
23
Sun, Xiao-Ming
20
Dinsdale, David
17
Dyer, Martin
17
Cain, Kelvin
11
Bratton, Shawn
9
Inoue, Satoshi
8
Harper, Nicholas
8
Butterworth, Michael
6
Snowden, Roger
5
Melino, Gerry
5
Inayat-Hussain, Salmaan
4
Brown, David
4
Knight, Richard
4
Langlais, C

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Publications

TOP 3
Inoue Satoshi; Harper Nick; Walewska Renata; Dyer Martin J S; Cohen Gerald M
Enhanced Fas-associated death domain recruitment by histone deacetylase inhibitors is critical for the sensitization of chronic lymphocytic leukemia cells to TRAIL-induced apoptosis.
Hughes Michelle A; Harper Nicholas; Butterworth Michael; Cain Kelvin; Cohen Gerald M; MacFarlane Marion
Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.
Sun Xiao-Ming; Canda-Sánchez Ana; Manjeri Ganesh R; Cohen Gerald M; Pinkoski Michael J
Phenylarsine oxide interferes with the death inducing signaling complex and inhibits tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced apoptosis.

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All Publications

2009: Inoue Satoshi; Harper Nick; Walewska Renata; Dyer Martin J S; Cohen Gerald M
Enhanced Fas-associated death domain recruitment by histone deacetylase inhibitors is critical for the sensitization of chronic lymphocytic leukemia cells to TRAIL-induced apoptosis.
Molecular cancer therapeutics 2009;8(11):3088-97.
2009: Hughes Michelle A; Harper Nicholas; Butterworth Michael; Cain Kelvin; Cohen Gerald M; MacFarlane Marion
Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.
Molecular cell 2009;35(3):265-79.
2009: Sun Xiao-Ming; Canda-Sánchez Ana; Manjeri Ganesh R; Cohen Gerald M; Pinkoski Michael J
Phenylarsine oxide interferes with the death inducing signaling complex and inhibits tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced apoptosis.
Experimental cell research 2009;315(14):2453-62.
2009: Vogler M; Weber K; Dinsdale D; Schmitz I; Schulze-Osthoff K; Dyer M J S; Cohen G M
Different forms of cell death induced by putative BCL2 inhibitors.
Cell death and differentiation 2009;16(7):1030-9.
2009: Inoue S; Browne G; Melino G; Cohen G M
Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway.
Cell death and differentiation 2009;16(7):1053-61.
2009: Vogler Meike; Butterworth Michael; Majid Aneela; Walewska Renata J; Sun Xiao-Ming; Dyer Martin J S; Cohen Gerald M
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia.
Blood 2009;113(18):4403-13.
2009: Vogler M; Dinsdale D; Dyer M J S; Cohen G M
Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.
Cell death and differentiation 2009;16(3):360-7.
2009: Rossi Mario; Inoue Satoshi; Walewska Renata; Knight Richard A; Dyer Martin J S; Cohen Gerald M; Melino Gerry
Caspase cleavage of Itch in chronic lymphocytic leukemia cells.
Biochemical and biophysical research communications 2009;379(3):659-64.
2008: Sayan A E; Sayan B S; Gogvadze V; Dinsdale D; Nyman U; Hansen T M; Zhivotovsky B; Cohen G M; Knight R A; Melino G
P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis.
Oncogene 2008;27(31):4363-72.
2008: Vogler M; Dinsdale D; Sun X-M; Young K W; Butterworth M; Nicotera P; Dyer M J S; Cohen G M
A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells.
Cell death and differentiation 2008;15(5):820-30.
2008: Inoue S; Walewska R; Dyer M J S; Cohen G M
Downregulation of Mcl-1 potentiates HDACi-mediated apoptosis in leukemic cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2008;22(4):819-25.
2007: Natoni Alessandro; MacFarlane Marion; Inoue Satoshi; Walewska Renata; Majid Aneela; Knee Deborah; Stover David R; Dyer Martin J S; Cohen Gerald M
TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2.
British journal of haematology 2007;139(4):568-77.
2007: Inoue S; Riley J; Gant T W; Dyer M J S; Cohen G M
Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2007;21(8):1773-82.
2007: Sayan Berna S; Sayan A Emre; Yang Ai Li; Aqeilan Rami I; Candi Eleonora; Cohen Gerald M; Knight Richard A; Croce Carlo M; Melino Gerry
Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):10871-6.
2007: Kohlhaas Susan L; Craxton Andrew; Sun Xiao-Ming; Pinkoski Michael J; Cohen Gerald M
Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.
The Journal of biological chemistry 2007;282(17):12831-41.
2007: Faragher Alison J; Sun Xiao-Ming; Butterworth Michael; Harper Nick; Mulheran Mike; Ruchaud Sandrine; Earnshaw William C; Cohen Gerald M
Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase.
Molecular biology of the cell 2007;18(4):1337-47.
2006: Inoue S; Twiddy D; Dyer M J S; Cohen G M
Upregulation of TRAIL-R2 is not involved in HDACi mediated sensitization to TRAIL-induced apoptosis.
Cell death and differentiation 2006;13(12):2160-2.
2006: Inoue Satoshi; Mai Antonello; Dyer Martin J S; Cohen Gerald M
Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.
Cancer research 2006;66(13):6785-92.
2006: Sayan Berna S; Sayan A Emre; Knight Richard A; Melino Gerry; Cohen Gerald M
p53 is cleaved by caspases generating fragments localizing to mitochondria.
The Journal of biological chemistry 2006;281(19):13566-73.
2006: Twiddy Davina; Cohen Gerald M; Macfarlane Marion; Cain Kelvin
Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex.
The Journal of biological chemistry 2006;281(7):3876-88.
2005: MacFarlane Marion; Kohlhaas Susan L; Sutcliffe Michael J; Dyer Martin J S; Cohen Gerald M
TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies.
Cancer research 2005;65(24):11265-70.
2005: MacFarlane M; Inoue S; Kohlhaas S L; Majid A; Harper N; Kennedy D B J; Dyer M J S; Cohen G M
Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1.
Cell death and differentiation 2005;12(7):773-82.
2004: Inoue S; MacFarlane M; Harper N; Wheat L M C; Dyer M J S; Cohen G M
Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies.
Cell death and differentiation 2004;11 Suppl 2():S193-206.
2004: Twiddy Davina; Brown David G; Adrain Colin; Jukes Rebekah; Martin Seamus J; Cohen Gerald M; MacFarlane Marion; Cain Kelvin
Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex.
The Journal of biological chemistry 2004;279(19):19665-82.
2004: Inoue S; Snowden R T; Dyer M J S; Cohen G M
CDDO induces apoptosis via the intrinsic pathway in lymphoid cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2004;18(5):948-52.
2004: Sun Xiao-Ming; Butterworth Michael; MacFarlane Marion; Dubiel Wolfgang; Ciechanover Aaron; Cohen Gerald M
Caspase activation inhibits proteasome function during apoptosis.
Molecular cell 2004;14(1):81-93.
2004: Dinsdale David; Lee Justine C; Dewson Grant; Cohen Gerald M; Peter Marcus E
Intermediate filaments control the intracellular distribution of caspases during apoptosis.
The American journal of pathology 2004;164(2):395-407.
2003: Harper Nicholas; Hughes Michelle A; Farrow Stuart N; Cohen Gerald M; MacFarlane Marion
Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling.
The Journal of biological chemistry 2003;278(45):44338-47.
2003: Snowden R T; Sun X-M; Dyer M J S; Cohen G M
Bisindolylmaleimide IX is a potent inducer of apoptosis in chronic lymphocytic leukaemic cells and activates cleavage of Mcl-1.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003;17(10):1981-9.
2003: Harper Nicholas; Hughes Michelle; MacFarlane Marion; Cohen Gerald M
Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis.
The Journal of biological chemistry 2003;278(28):25534-41.
2003: Dewson Grant; Snowden Roger T; Almond Jason B; Dyer Martin J S; Cohen Gerald M
Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.
Oncogene 2003;22(17):2643-54.
2003: Bratton S B; Cohen G M
Death receptors leave a caspase footprint that Smacs of XIAP.
Cell death and differentiation 2003;10(1):4-6.
2002: MacFarlane Marion; Harper Nicholas; Snowden Roger T; Dyer Martin J S; Barnett Georgina A; Pringle J Howard; Cohen Gerald M
Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia.
Oncogene 2002;21(44):6809-18.
2002: Lee Justine C; Schickling Olaf; Stegh Alexander H; Oshima Robert G; Dinsdale David; Cohen Gerald M; Peter Marcus E
DEDD regulates degradation of intermediate filaments during apoptosis.
The Journal of cell biology 2002;158(6):1051-66.
2002: Bratton S B; Lewis J; Butterworth M; Duckett C S; Cohen G M
XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis.
Cell death and differentiation 2002;9(9):881-92.
2002: MacFarlane Marion; Merrison Wendy; Bratton Shawn B; Cohen Gerald M
Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
The Journal of biological chemistry 2002;277(39):36611-6.
2002: Almond J B; Cohen G M
The proteasome: a novel target for cancer chemotherapy.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2002;16(4):433-43.
2002: Sun Xiao-Ming; Bratton Shawn B; Butterworth Michael; MacFarlane Marion; Cohen Gerald M
Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein.
The Journal of biological chemistry 2002;277(13):11345-51.
2002: Cain Kelvin; Bratton Shawn B; Cohen Gerald M
The Apaf-1 apoptosome: a large caspase-activating complex.
Biochimie 2002;84(2-3):203-14.
2001: Cain K; Langlais C; Sun X M; Brown D G; Cohen G M
Physiological concentrations of K+ inhibit cytochrome c-dependent formation of the apoptosome.
The Journal of biological chemistry 2001;276(45):41985-90.
2001: Dewson G; Cohen G M; Wardlaw A J
Interleukin-5 inhibits translocation of Bax to the mitochondria, cytochrome c release, and activation of caspases in human eosinophils.
Blood 2001;98(7):2239-47.
2001: Almond J B; Snowden R T; Hunter A; Dinsdale D; Cain K; Cohen G M
Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2001;15(9):1388-97.
2001: Harper N; Farrow S N; Kaptein A; Cohen G M; MacFarlane M
Modulation of tumor necrosis factor apoptosis-inducing ligand- induced NF-kappa B activation by inhibition of apical caspases.
The Journal of biological chemistry 2001;276(37):34743-52.
2001: Thompson G J; Langlais C; Cain K; Conley E C; Cohen G M
Elevated extracellular [K+] inhibits death-receptor- and chemical-mediated apoptosis prior to caspase activation and cytochrome c release.
The Biochemical journal 2001;357(Pt 1):137-45.
2001: Bratton S B; Cohen G M
Apoptotic death sensor: an organelle's alter ego?
Trends in pharmacological sciences 2001;22(6):306-15.
2001: Greaves P; Edwards R; Cohen G M; MacFarlane M
"Have you seen this?" Diffuse hepatic apoptosis.
Toxicologic pathology 2001;29(3):398-400.
2001: Bratton S B; Walker G; Roberts D L; Cain K; Cohen G M
Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex.
Cell death and differentiation 2001;8(4):425-33.
2001: Roberts D L; Merrison W; MacFarlane M; Cohen G M
The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity.
The Journal of cell biology 2001;153(1):221-8.
2001: Bratton S B; Walker G; Srinivasula S M; Sun X M; Butterworth M; Alnemri E S; Cohen G M
Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes.
The EMBO journal 2001;20(5):998-1009.
2001: Bratton S B; Cohen G M
Caspase cascades in chemically-induced apoptosis.
Advances in experimental medicine and biology 2001;500():407-20.
2000: Beere H M; Wolf B B; Cain K; Mosser D D; Mahboubi A; Kuwana T; Tailor P; Morimoto R I; Cohen G M; Green D R
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome.
Nature cell biology 2000;2(8):469-75.
2000: MacFarlane M; Cohen G M; Dickens M
JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation.
The Biochemical journal 2000;348 Pt 1():93-101.
2000: Bratton S B; MacFarlane M; Cain K; Cohen G M
Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis.
Experimental cell research 2000;256(1):27-33.
2000: MacFarlane M; Merrison W; Dinsdale D; Cohen G M
Active caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions in TRAIL-induced apoptosis.
The Journal of cell biology 2000;148(6):1239-54.
2000: Cain K; Bratton S B; Langlais C; Walker G; Brown D G; Sun X M; Cohen G M
Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes.
The Journal of biological chemistry 2000;275(9):6067-70.
1999: Cain K; Brown D G; Langlais C; Cohen G M
Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex.
The Journal of biological chemistry 1999;274(32):22686-92.
1999: Sun X M; MacFarlane M; Zhuang J; Wolf B B; Green D R; Cohen G M
Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.
The Journal of biological chemistry 1999;274(8):5053-60.
1999: Chow S C; Slee E A; MacFarlane M; Cohen G M
Caspase-1 is not involved in CD95/Fas-induced apoptosis in Jurkat T cells.
Experimental cell research 1999;246(2):491-500.
1998: Zhuang J; Cohen G M
Release of mitochondrial cytochrome c is upstream of caspase activation in chemical-induced apoptosis in human monocytic tumour cells.
Toxicology letters 1998;102-103():121-9.
1998: Zhuang J; Dinsdale D; Cohen G M
Apoptosis, in human monocytic THP.1 cells, results in the release of cytochrome c from mitochondria prior to their ultracondensation, formation of outer membrane discontinuities and reduction in inner membrane potential.
Cell death and differentiation 1998;5(11):953-62.
1998: King D; Pringle J H; Hutchinson M; Cohen G M
Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lymphocytic leukemia cells.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1998;12(10):1553-60.
1998: Harkin S T; Cohen G M; Gescher A
Modulation of apoptosis in rat thymocytes by analogs of staurosporine: lack of direct association with inhibition of protein kinase C.
Molecular pharmacology 1998;54(4):663-70.
1998: Zhuang J; Ren Y; Snowden R T; Zhu H; Gogvadze V; Savill J S; Cohen G M
Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program.
The Journal of biological chemistry 1998;273(25):15628-32.
1998: Chandler J M; Cohen G M; MacFarlane M
Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver.
The Journal of biological chemistry 1998;273(18):10815-8.
1997: Zhu H; Dinsdale D; Alnemri E S; Cohen G M
Apoptosis in human monocytic THP.1 cells involves several distinct targets of N-tosyl-L-phenylalanyl chloromethyl ketone (TPCK).
Cell death and differentiation 1997;4(7):590-9.
1997: Cohen G M
Caspases: the executioners of apoptosis.
The Biochemical journal 1997;326 ( Pt 1)():1-16.
1997: Inayat-Hussain S H; Couet C; Cohen G M; Cain K
Processing/activation of CPP32-like proteases is involved in transforming growth factor beta1-induced apoptosis in rat hepatocytes.
Hepatology (Baltimore, Md.) 1997;25(6):1516-26.
1997: MacFarlane M; Cain K; Sun X M; Alnemri E S; Cohen G M
Processing/activation of at least four interleukin-1beta converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells.
The Journal of cell biology 1997;137(2):469-79.
1997: Chandler J M; Alnemri E S; Cohen G M; MacFarlane M
Activation of CPP32 and Mch3 alpha in wild-type p53-induced apoptosis.
The Biochemical journal 1997;322 ( Pt 1)():19-23.
1996: MacFarlane M; Jones N A; Dive C; Cohen G M
DNA-damaging agents induce both p53-dependent and p53-independent apoptosis in immature thymocytes.
Molecular pharmacology 1996;50(4):900-11.
1996: Slee E A; Zhu H; Chow S C; MacFarlane M; Nicholson D W; Cohen G M
Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.
The Biochemical journal 1996;315 ( Pt 1)():21-4.
1996: Cain K; Inayat-Hussain S H; Couet C; Cohen G M
A cleavage-site-directed inhibitor of interleukin-1 beta-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes.
The Biochemical journal 1996;314 ( Pt 1)():27-32.
1995: Fearnhead H O; MacFarlane M; Dinsdale D; Cohen G M
DNA degradation and proteolysis in thymocyte apoptosis.
Toxicology letters 1995;82-83():135-41.
1995: Fearnhead H O; Dinsdale D; Cohen G M
An interleukin-1 beta-converting enzyme-like protease is a common mediator of apoptosis in thymocytes.
FEBS letters 1995;375(3):283-8.
1995: Zhu H; Fearnhead H O; Cohen G M
An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells.
FEBS letters 1995;374(2):303-8.
1995: Bicknell G R; Cohen G M
Cleavage of DNA to large kilobase pair fragments occurs in some forms of necrosis as well as apoptosis.
Biochemical and biophysical research communications 1995;207(1):40-7.
1995: Cain K; Inayat-Hussain S H; Kokileva L; Cohen G M
Multi-step DNA cleavage in rat liver nuclei is inhibited by thiol reactive agents.
FEBS letters 1995;358(3):255-61.
1995: Fearnhead H O; Rivett A J; Dinsdale D; Cohen G M
A pre-existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli.
FEBS letters 1995;357(3):242-6.
1994: Cain K; Inayat-Hussain S H; Kokileva L; Cohen G M
DNA cleavage in rat liver nuclei activated by Mg2+ or Ca2+ + Mg2+ is inhibited by a variety of structurally unrelated inhibitors.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1994;72(11-12):631-8.
1994: Verschoyle R D; Carthew P; Holley J L; Cullis P; Cohen G M
The comparative toxicity of chlorambucil and chlorambucil-spermidine conjugate to BALB/c mice.
Cancer letters 1994;85(2):217-22.
1994: Sun X M; Carthew P; Dinsdale D; Snowden R T; Cohen G M
The involvement of apoptosis in etoposide-induced thymic atrophy.
Toxicology and applied pharmacology 1994;128(1):78-85.
1994: Fearnhead H O; Chwalinski M; Snowden R T; Ormerod M G; Cohen G M
Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle.
Biochemical pharmacology 1994;48(6):1073-9.
1994: Wolfe J T; Ross D; Cohen G M
A role for metals and free radicals in the induction of apoptosis in thymocytes.
FEBS letters 1994;352(1):58-62.
1994: Norbury C; MacFarlane M; Fearnhead H; Cohen G M
Cdc2 activation is not required for thymocyte apoptosis.
Biochemical and biophysical research communications 1994;202(3):1400-6.
1994: Cain K; Inayat-Hussain S H; Wolfe J T; Cohen G M
DNA fragmentation into 200-250 and/or 30-50 kilobase pair fragments in rat liver nuclei is stimulated by Mg2+ alone and Ca2+/Mg2+ but not by Ca2+ alone.
FEBS letters 1994;349(3):385-91.
1994: Cohen G M; Sun X M; Fearnhead H; MacFarlane M; Brown D G; Snowden R T; Dinsdale D
Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(2):507-16.
1994: Sun X M; Cohen G M
Mg(2+)-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis.
The Journal of biological chemistry 1994;269(21):14857-60.
1994: Sun X M; Snowden R T; Dinsdale D; Ormerod M G; Cohen G M
Changes in nuclear chromatin precede internucleosomal DNA cleavage in the induction of apoptosis by etoposide.
Biochemical pharmacology 1994;47(2):187-95.
1993: Butterworth M; Upshall D G; Cohen G M
A novel role for carboxylesterase in the elevation of cellular cysteine by esters of cysteine.
Biochemical pharmacology 1993;46(7):1131-7.
1993: Cohen G M; Sun X M; Snowden R T; Ormerod M G; Dinsdale D
Identification of a transitional preapoptotic population of thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(2):566-74.
1993: Butterworth M; Upshall D G; Hobbs M; Cohen G M
Elevation of cysteine and replenishment of glutathione in rat lung slices by cysteine isopropylester and other cysteine precursors.
Biochemical pharmacology 1993;45(9):1769-74.
1993: Hobbs M J; Butterworth M; Cohen G M; Upshall D G
Structure-activity relationships of cysteine esters and their effects on thiol levels in rat lung in vitro.
Biochemical pharmacology 1993;45(8):1605-12.
1993: Raffray M; McCarthy D; Snowden R T; Cohen G M
Apoptosis as a mechanism of tributyltin cytotoxicity to thymocytes: relationship of apoptotic markers to biochemical and cellular effects.
Toxicology and applied pharmacology 1993;119(1):122-30.
1993: Brown D G; Sun X M; Cohen G M
Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation.
The Journal of biological chemistry 1993;268(5):3037-9.
1993: Raffray M; Cohen G M
Thymocyte apoptosis as a mechanism for tributyltin-induced thymic atrophy in vivo.
Archives of toxicology 1993;67(4):231-6.
1993: Ormerod M G; Sun X M; Snowden R T; Davies R; Fearnhead H; Cohen G M
Increased membrane permeability of apoptotic thymocytes: a flow cytometric study.
Cytometry 1993;14(6):595-602.
1993: Ormerod M G; Sun X M; Brown D; Snowden R T; Cohen G M
Quantification of apoptosis and necrosis by flow cytometry.
Acta oncologica (Stockholm, Sweden) 1993;32(4):417-24.
1992: Sun X M; Dinsdale D; Snowden R T; Cohen G M; Skilleter D N
Characterization of apoptosis in thymocytes isolated from dexamethasone-treated rats.
Biochemical pharmacology 1992;44(11):2131-7.
1992: Cohen G M; Sun X M; Snowden R T; Dinsdale D; Skilleter D N
Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation.
The Biochemical journal 1992;286 ( Pt 2)():331-4.
1992: Holley J L; Mather A; Wheelhouse R T; Cullis P M; Hartley J A; Bingham J P; Cohen G M
Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate.
Cancer research 1992;52(15):4190-5.
1992: Sun X M; Snowden R T; Skilleter D N; Dinsdale D; Ormerod M G; Cohen G M
A flow-cytometric method for the separation and quantitation of normal and apoptotic thymocytes.
Analytical biochemistry 1992;204(2):351-6.
1992: Morgan W A; Hartley J A; Cohen G M
Quinone-induced DNA single strand breaks in rat hepatocytes and human chronic myelogenous leukaemic K562 cells.
Biochemical pharmacology 1992;44(2):215-21.
1992: Holley J; Mather A; Cullis P; Symons M R; Wardman P; Watt R A; Cohen G M
Uptake and cytotoxicity of novel nitroimidazole-polyamine conjugates in Ehrlich ascites tumour cells.
Biochemical pharmacology 1992;43(4):763-9.
1992: Butterworth M; Upshall D G; Smith L L; Cohen G M
Cysteine isopropylester protects against paracetamol-induced toxicity.
Biochemical pharmacology 1992;43(3):483-8.
1991: Hardwick S J; Skamarauskas J T; Smith L L; Upshall D G; Cohen G M
Protection of rats against the effects of alpha-naphthylthiourea (ANTU) by elevation of non-protein sulphydryl levels.
Biochemical pharmacology 1991;42(6):1203-8.
1991: Raffray M; Cohen G M
Bis(tri-n-butyltin)oxide induces programmed cell death (apoptosis) in immature rat thymocytes.
Archives of toxicology 1991;65(2):135-9.
1990: Adam A; Smith L L; Cohen G M
An evaluation of the redox cycling potencies of paraquat and nitrofurantoin in microsomal and lung slice systems.
Biochemical pharmacology 1990;40(7):1533-9.
1990: Cohen G M; Smith L L
Potential therapeutic exploitation of the pulmonary polyamine uptake system.
Biochemical Society transactions 1990;18(5):743-5.
1990: Adam A; Smith L L; Cohen G M
An assessment of the role of redox cycling in mediating the toxicity of paraquat and nitrofurantoin.
Environmental health perspectives 1990;85():113-7.
1990: Cohen G M
Pulmonary metabolism of foreign compounds: its role in metabolic activation.
Environmental health perspectives 1990;85():31-41.
1990: Hardwick S J; Adam A; Smith L L; Cohen G M
A novel lung slice system with compromised antioxidant defenses.
Environmental health perspectives 1990;85():129-33.
1990: Hardwick S J; Adam A; Smith L L; Cohen G M
Potentiation of the cell specific toxicity of paraquat by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Implications for the heterogeneous distribution of glutathione (GSH) in rat lung.
Biochemical pharmacology 1990;39(3):581-9.
1990: Cohen G M; Stubberfield C R
Pyridine nucleotide changes in hepatocytes exposed to quinones.
Free radical research communications 1990;8(4-6):355-63.
1989: Stubberfield C R; Cohen G M
Interconversion of NAD(H) to NADP(H). A cellular response to quinone-induced oxidative stress in isolated hepatocytes.
Biochemical pharmacology 1989;38(16):2631-7.
1988: Stubberfield C R; Cohen G M
NAD+ depletion and cytotoxicity in isolated hepatocytes.
Biochemical pharmacology 1988;37(20):3967-74.
1988: Gant T W; Rao D N; Mason R P; Cohen G M
Redox cycling and sulphydryl arylation; their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes.
Chemico-biological interactions 1988;65(2):157-73.

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