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Gerald Cohen

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Chemicals & Drugs

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B-Cell Chronic Lymphocytic Leukemia

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Shankar Varadarajan; Jun Wei; Michael Butterworth; David Dinsdale; Maurizio Pellecchia; Gerald M Cohen
Sabutoclax (BI97C1) and BI112D1, Putative Inhibitors of MCL-1, Induce Mitochondrial Fragmentation Either Upstream of or Independent of Apoptosis.
Shankar Varadarajan; Gary B Willars; Edward T W Bampton; David Dinsdale; Maurizio Pellecchia; Joshua L Smalley; Kayoko Tanaka; Gerald M Cohen
Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.
S Varadarajan; J Wei; E T W Bampton; Michael Butterworth; R E Caves; David Dinsdale; T W Gant; J Mitcheson; M Pellecchia; J L Smalley; K Tanaka; Gerald M Cohen
A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.

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2013: Shankar Varadarajan; Jun Wei; Michael Butterworth; David Dinsdale; Maurizio Pellecchia; Gerald M Cohen
Sabutoclax (BI97C1) and BI112D1, Putative Inhibitors of MCL-1, Induce Mitochondrial Fragmentation Either Upstream of or Independent of Apoptosis.
Neoplasia (New York, N.Y.) 2013;15(5):568-78.
2013: Shankar Varadarajan; Gary B Willars; Edward T W Bampton; David Dinsdale; Maurizio Pellecchia; Joshua L Smalley; Kayoko Tanaka; Gerald M Cohen
Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.
PloS one 2013;8(2):e56603.
2012: S Varadarajan; J Wei; E T W Bampton; Michael Butterworth; R E Caves; David Dinsdale; T W Gant; J Mitcheson; M Pellecchia; J L Smalley; K Tanaka; Gerald M Cohen
A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.
Cell death and differentiation 2012;19(12):1896-907.
2012: A Craxton; L Fairall; N Harper; John W R Schwabe; M Butterworth; Aaron Ciechanover; Gerald M Cohen
NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1.
Cell death and differentiation 2012;19(9):1424-34.
2011: Meike Vogler; Edward T W Bampton; David Dinsdale; Martin J S Dyer; Alison H Goodall; Hassan A Hamali; Roger T Snowden; Xiao-Ming Sun; Gerald M Cohen
BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.
Blood 2011;117(26):7145-54.
2011: Meike Vogler; David Dickens; Martin J S Dyer; Andrew Owen; Munir Pirmohamed; Gerald M Cohen
The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein.
Biochemical and biophysical research communications 2011;408(2):344-9.
2010: Maria Baou; Susan L Kohlhaas; Michael Butterworth; Meike Vogler; David Dinsdale; Renata Walewska; Aneela Majid; Eric Eldering; Martin J S Dyer; Gerald M Cohen
Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.
Haematologica 2010;95(9):1510-8.
2009: Satoshi Inoue; Nick Harper; Renata Walewska; Martin J S Dyer; Gerald M Cohen
Enhanced Fas-associated death domain recruitment by histone deacetylase inhibitors is critical for the sensitization of chronic lymphocytic leukemia cells to TRAIL-induced apoptosis.
Molecular cancer therapeutics 2009;8(11):3088-97.
2009: Xiao-Ming Sun; Ana Canda-Sánchez; Ganesh Ramesh Manjeri; Gerald M Cohen; Michael J Pinkoski
Phenylarsine oxide interferes with the death inducing signaling complex and inhibits tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induced apoptosis.
Experimental cell research 2009;315(14):2453-62.
2009: Michelle A Hughes; Nicholas Harper; Michael Butterworth; Kelvin Cain; Gerald M Cohen; Marion MacFarlane
Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.
Molecular cell 2009;35(3):265-79.
2009: M Vogler; K Weber; David Dinsdale; I Schmitz; K Schulze-Osthoff; Martin J S Dyer; Gerald M Cohen
Different forms of cell death induced by putative BCL2 inhibitors.
Cell death and differentiation 2009;16(7):1030-9.
2009: Satoshi Inoue; G Browne; Gerry Melino; Gerald M Cohen
Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway.
Cell death and differentiation 2009;16(7):1053-61.
2009: Meike Vogler; Michael Butterworth; Aneela Majid; Renata Walewska; Xiao-Ming Sun; Martin J S Dyer; Gerald M Cohen
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia.
Blood 2009;113(18):4403-13.
2009: M Vogler; David Dinsdale; Martin J S Dyer; Gerald M Cohen
Bcl-2 inhibitors: small molecules with a big impact on cancer therapy.
Cell death and differentiation 2009;16(3):360-7.
2009: Mario Rossi; Satoshi Inoue; Renata Walewska; Richard A Knight; Martin J S Dyer; Gerald M Cohen; Gerry Melino
Caspase cleavage of Itch in chronic lymphocytic leukemia cells.
Biochemical and biophysical research communications 2009;379(3):659-64.
2008: emre sayan; Berna S Sayan; V Gogvadze; David Dinsdale; U Nyman; Tania Wilmann; B Zhivotovsky; Gerald M Cohen; Richard A Knight; Gerry Melino
P73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis.
Oncogene 2008;27(31):4363-72.
2008: M Vogler; David Dinsdale; Xiao-Ming Sun; Kenneth W Young; Michael Butterworth; Pierluigi Nicotera; Martin J S Dyer; Gerald M Cohen
A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells.
Cell death and differentiation 2008;15(5):820-30.
2008: Satoshi Inoue; Renata Walewska; Martin J S Dyer; Gerald M Cohen
Downregulation of Mcl-1 potentiates HDACi-mediated apoptosis in leukemic cells.
Leukemia 2008;22(4):819-25.
2007: Alessandro Natoni; Marion MacFarlane; Satoshi Inoue; Renata Walewska; Aneela Majid; Deborah Knee; David R Stover; Martin J S Dyer; Gerald M Cohen
TRAIL signals to apoptosis in chronic lymphocytic leukaemia cells primarily through TRAIL-R1 whereas cross-linked agonistic TRAIL-R2 antibodies facilitate signalling via TRAIL-R2.
British journal of haematology 2007;139(4):568-77.
2007: Satoshi Inoue; J Riley; Timothy W Gant; Martin J S Dyer; Gerald M Cohen
Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa.
Leukemia 2007;21(8):1773-82.
2007: Berna S Sayan; emre sayan; Ai Li Yang; Rami I Aqeilan; Eleonora Candi; Gerald M Cohen; Richard A Knight; Carlo M Croce; Gerry Melino
Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):10871-6.
2007: Susan L Kohlhaas; Andrew Craxton; Xiao-Ming Sun; Michael J Pinkoski; Gerald M Cohen
Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis.
The Journal of biological chemistry 2007;282(17):12831-41.
2007: Alison J Faragher; Xiao-Ming Sun; Michael Butterworth; Nicholas Harper; Mike Mulheran; Sandrine Ruchaud; William C Earnshaw; Gerald M Cohen
Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase.
Molecular biology of the cell 2007;18(4):1337-47.
2006: S Inoue; Davina Twiddy; M J S Dyer; Gerald M Cohen
Upregulation of TRAIL-R2 is not involved in HDACi mediated sensitization to TRAIL-induced apoptosis.
Cell death and differentiation 2006;13(12):2160-2.
2006: Satoshi Inoue; Antonello Mai; Martin J S Dyer; Gerald M Cohen
Inhibition of histone deacetylase class I but not class II is critical for the sensitization of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.
Cancer research 2006;66(13):6785-92.
2006: Berna S Sayan; emre sayan; Richard A Knight; Gerry Melino; Gerald M Cohen
p53 is cleaved by caspases generating fragments localizing to mitochondria.
The Journal of biological chemistry 2006;281(19):13566-73.
2006: Davina Twiddy; Gerald M Cohen; Marion MacFarlane; Kelvin Cain
Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex.
The Journal of biological chemistry 2006;281(7):3876-88.
2005: Marion MacFarlane; Susan L Kohlhaas; Michael J Sutcliffe; Martin J S Dyer; Gerald M Cohen
TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignancies.
Cancer research 2005;65(24):11265-70.
2005: Marion MacFarlane; Satoshi Inoue; Susan L Kohlhaas; Aneela Majid; Nicholas Harper; D B J Kennedy; Martin J S Dyer; Gerald M Cohen
Chronic lymphocytic leukemic cells exhibit apoptotic signaling via TRAIL-R1.
Cell death and differentiation 2005;12(7):773-82.
2004: Satoshi Inoue; Marion MacFarlane; Nicholas Harper; L M C Wheat; Martin J S Dyer; Gerald M Cohen
Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies.
Cell death and differentiation 2004;11 Suppl 2():S193-206.
2004: Davina Twiddy; David G Brown; colin adrain; Rebekah Jukes; Seamus Martin; Gerald M Cohen; Marion MacFarlane; Kelvin Cain
Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex.
The Journal of biological chemistry 2004;279(19):19665-82.
2004: Satoshi Inoue; Roger T Snowden; Martin J S Dyer; Gerald M Cohen
CDDO induces apoptosis via the intrinsic pathway in lymphoid cells.
Leukemia 2004;18(5):948-52.
2004: Xiao-Ming Sun; Michael Butterworth; Marion MacFarlane; Wolfgang Dubiel; Aaron Ciechanover; Gerald M Cohen
Caspase activation inhibits proteasome function during apoptosis.
Molecular cell 2004;14(1):81-93.
2004: David Dinsdale; Justine C Lee; Grant Dewson; Gerald M Cohen; Marcus E Peter
Intermediate filaments control the intracellular distribution of caspases during apoptosis.
The American journal of pathology 2004;164(2):395-407.
2003: Nicholas Harper; Michelle A Hughes; Stuart N Farrow; Gerald M Cohen; Marion MacFarlane
Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling.
The Journal of biological chemistry 2003;278(45):44338-47.
2003: Roger T Snowden; Xiao-Ming Sun; Martin J S Dyer; Gerald M Cohen
Bisindolylmaleimide IX is a potent inducer of apoptosis in chronic lymphocytic leukaemic cells and activates cleavage of Mcl-1.
Leukemia 2003;17(10):1981-9.
2003: Nicholas Harper; Michelle Hughes; Marion MacFarlane; Gerald M Cohen
Fas-associated death domain protein and caspase-8 are not recruited to the tumor necrosis factor receptor 1 signaling complex during tumor necrosis factor-induced apoptosis.
The Journal of biological chemistry 2003;278(28):25534-41.
2003: Grant Dewson; Roger T Snowden; Jason B Almond; Martin J S Dyer; Gerald M Cohen
Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.
Oncogene 2003;22(17):2643-54.
2003: Shawn B Bratton; Gerald M Cohen
Death receptors leave a caspase footprint that Smacs of XIAP.
Cell death and differentiation 2003;10(1):4-6.
2002: Marion MacFarlane; Nicholas Harper; Roger T Snowden; Martin J S Dyer; Georgina A Barnett; James Pringle; Gerald M Cohen
Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia.
Oncogene 2002;21(44):6809-18.
2002: Marion MacFarlane; Wendy Merrison; Shawn B Bratton; Gerald M Cohen
Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
The Journal of biological chemistry 2002;277(39):36611-6.
2002: Justine C Lee; Olaf Schickling; Alexander H Stegh; Robert Glen Oshima; David Dinsdale; Gerald M Cohen; Marcus E Peter
DEDD regulates degradation of intermediate filaments during apoptosis.
The Journal of cell biology 2002;158(6):1051-66.
2002: Shawn B Bratton; J Lewis; Michael Butterworth; Colin S Duckett; Gerald M Cohen
XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis.
Cell death and differentiation 2002;9(9):881-92.
2002: Jason B Almond; Gerald M Cohen
The proteasome: a novel target for cancer chemotherapy.
Leukemia 2002;16(4):433-43.
2002: Xiao-Ming Sun; Shawn B Bratton; Michael Butterworth; Marion MacFarlane; Gerald M Cohen
Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein.
The Journal of biological chemistry 2002;277(13):11345-51.
2002: Kelvin Cain; Shawn B Bratton; Gerald M Cohen
The Apaf-1 apoptosome: a large caspase-activating complex.
Biochimie 2002;84(2-3):203-14.
2001: Kelvin Cain; C Langlais; Xiao-Ming Sun; David G Brown; Gerald M Cohen
Physiological concentrations of K+ inhibit cytochrome c-dependent formation of the apoptosome.
The Journal of biological chemistry 2001;276(45):41985-90.
2001: Grant Dewson; Gerald M Cohen; Andrew J Wardlaw
Interleukin-5 inhibits translocation of Bax to the mitochondria, cytochrome c release, and activation of caspases in human eosinophils.
Blood 2001;98(7):2239-47.
2001: Nicholas Harper; Stuart N Farrow; A Kaptein; Gerald M Cohen; Marion MacFarlane
Modulation of tumor necrosis factor apoptosis-inducing ligand- induced NF-kappa B activation by inhibition of apical caspases.
The Journal of biological chemistry 2001;276(37):34743-52.
2001: Jason B Almond; Roger T Snowden; A Hunter; David Dinsdale; Kelvin Cain; Gerald M Cohen
Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex.
Leukemia 2001;15(9):1388-97.
2001: G J Thompson; C Langlais; Kelvin Cain; Edward C Conley; Gerald M Cohen
Elevated extracellular [K+] inhibits death-receptor- and chemical-mediated apoptosis prior to caspase activation and cytochrome c release.
The Biochemical journal 2001;357(Pt 1):137-45.
2001: Shawn B Bratton; Gerald M Cohen
Apoptotic death sensor: an organelle's alter ego?
Trends in pharmacological sciences 2001;22(6):306-15.
2001: Peter Greaves; Richard Edwards; Gerald M Cohen; Marion MacFarlane
"Have you seen this?" Diffuse hepatic apoptosis.
Toxicologic pathology 2001;29(3):398-400.
2001: DL Roberts; Wendy Merrison; Marion MacFarlane; Gerald M Cohen
The inhibitor of apoptosis protein-binding domain of Smac is not essential for its proapoptotic activity.
The Journal of cell biology 2001;153(1):221-8.
2001: Shawn B Bratton; G Walker; DL Roberts; Kelvin Cain; Gerald M Cohen
Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex.
Cell death and differentiation 2001;8(4):425-33.
2001: Shawn B Bratton; G Walker; S M Srinivasula; Xiao-Ming Sun; Michael Butterworth; E S Alnemri; Gerald M Cohen
Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes.
The EMBO journal 2001;20(5):998-1009.
2001: Shawn B Bratton; Gerald M Cohen
Caspase cascades in chemically-induced apoptosis.
Advances in experimental medicine and biology 2001;500():407-20.
2000: Helen M Beere; BB Wolf; K Cain; D D Mosser; A Mahboubi; Tomomi Kuwana; Pankaj Tailor; R I Morimoto; Gerald M Cohen; Douglas R Green
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome.
Nature cell biology 2000;2(8):469-75.
2000: Marion MacFarlane; Gerald M Cohen; Martin Dickens
JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation.
The Biochemical journal 2000;348 Pt 1():93-101.
2000: Shawn B Bratton; Marion MacFarlane; Kelvin Cain; Gerald M Cohen
Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis.
Experimental cell research 2000;256(1):27-33.
2000: Marion MacFarlane; Wendy Merrison; David Dinsdale; Gerald M Cohen
Active caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions in TRAIL-induced apoptosis.
The Journal of cell biology 2000;148(6):1239-54.
2000: Kelvin Cain; Shawn B Bratton; C Langlais; G Walker; David G Brown; Xiao-Ming Sun; Gerald M Cohen
Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes.
The Journal of biological chemistry 2000;275(9):6067-70.
1999: Kelvin Cain; David G Brown; C Langlais; Gerald M Cohen
Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex.
The Journal of biological chemistry 1999;274(32):22686-92.
1999: Xiao-Ming Sun; Marion MacFarlane; J Zhuang; BB Wolf; Douglas R Green; Gerald M Cohen
Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis.
The Journal of biological chemistry 1999;274(8):5053-60.
1999: Sek C Chow; EA Slee; Marion MacFarlane; Gerald M Cohen
Caspase-1 is not involved in CD95/Fas-induced apoptosis in Jurkat T cells.
Experimental cell research 1999;246(2):491-500.
1998: J Zhuang; Gerald M Cohen
Release of mitochondrial cytochrome c is upstream of caspase activation in chemical-induced apoptosis in human monocytic tumour cells.
Toxicology letters 1998;102-103():121-9.
1998: J Zhuang; David Dinsdale; Gerald M Cohen
Apoptosis, in human monocytic THP.1 cells, results in the release of cytochrome c from mitochondria prior to their ultracondensation, formation of outer membrane discontinuities and reduction in inner membrane potential.
Cell death and differentiation 1998;5(11):953-62.
1998: D King; James Pringle; M Hutchinson; Gerald M Cohen
Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lymphocytic leukemia cells.
Leukemia 1998;12(10):1553-60.
1998: S T Harkin; Gerald M Cohen; Andreas J Gescher
Modulation of apoptosis in rat thymocytes by analogs of staurosporine: lack of direct association with inhibition of protein kinase C.
Molecular pharmacology 1998;54(4):663-70.
1998: J Zhuang; Y Ren; Roger T Snowden; H Zhu; V Gogvadze; J S Savill; Gerald M Cohen
Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program.
The Journal of biological chemistry 1998;273(25):15628-32.
1998: J M Chandler; Gerald M Cohen; Marion MacFarlane
Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver.
The Journal of biological chemistry 1998;273(18):10815-8.
1997: H Zhu; David Dinsdale; E S Alnemri; Gerald M Cohen
Apoptosis in human monocytic THP.1 cells involves several distinct targets of N-tosyl-L-phenylalanyl chloromethyl ketone (TPCK).
Cell death and differentiation 1997;4(7):590-9.
1997: Gerald M Cohen
Caspases: the executioners of apoptosis.
The Biochemical journal 1997;326 ( Pt 1)():1-16.
1997: Salmaan H Inayat-Hussain; C Couet; Gerald M Cohen; Kelvin Cain
Processing/activation of CPP32-like proteases is involved in transforming growth factor beta1-induced apoptosis in rat hepatocytes.
Hepatology (Baltimore, Md.) 1997;25(6):1516-26.
1997: Marion MacFarlane; Kelvin Cain; Xiao-Ming Sun; E S Alnemri; Gerald M Cohen
Processing/activation of at least four interleukin-1beta converting enzyme-like proteases occurs during the execution phase of apoptosis in human monocytic tumor cells.
The Journal of cell biology 1997;137(2):469-79.
1997: J M Chandler; E S Alnemri; Gerald M Cohen; Marion MacFarlane
Activation of CPP32 and Mch3 alpha in wild-type p53-induced apoptosis.
The Biochemical journal 1997;322 ( Pt 1)():19-23.
1996: M MacFarlane; N A Jones; C Dive; Gerald M Cohen
DNA-damaging agents induce both p53-dependent and p53-independent apoptosis in immature thymocytes.
Molecular pharmacology 1996;50(4):900-11.
1996: EA Slee; H Zhu; Sek C Chow; Marion MacFarlane; D W Nicholson; Gerald M Cohen
Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32.
The Biochemical journal 1996;315 ( Pt 1)():21-4.
1996: Kelvin Cain; Salmaan H Inayat-Hussain; C Couet; Gerald M Cohen
A cleavage-site-directed inhibitor of interleukin-1 beta-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes.
The Biochemical journal 1996;314 ( Pt 1)():27-32.
1995: Howard Fearnhead; M MacFarlane; David Dinsdale; Gerald M Cohen
DNA degradation and proteolysis in thymocyte apoptosis.
Toxicology letters 1995;82-83():135-41.
1995: Howard Fearnhead; David Dinsdale; Gerald M Cohen
An interleukin-1 beta-converting enzyme-like protease is a common mediator of apoptosis in thymocytes.
FEBS letters 1995;375(3):283-8.
1995: H Zhu; Howard Fearnhead; Gerald M Cohen
An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells.
FEBS letters 1995;374(2):303-8.
1995: Gareth R Bicknell; Gerald M Cohen
Cleavage of DNA to large kilobase pair fragments occurs in some forms of necrosis as well as apoptosis.
Biochemical and biophysical research communications 1995;207(1):40-7.
1995: Kelvin Cain; Salmaan H Inayat-Hussain; L Kokileva; Gerald M Cohen
Multi-step DNA cleavage in rat liver nuclei is inhibited by thiol reactive agents.
FEBS letters 1995;358(3):255-61.
1995: Howard Fearnhead; A Jennifer Rivett; David Dinsdale; Gerald M Cohen
A pre-existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli.
FEBS letters 1995;357(3):242-6.
1994: Kelvin Cain; Salmaan H Inayat-Hussain; L Kokileva; Gerald M Cohen
DNA cleavage in rat liver nuclei activated by Mg2+ or Ca2+ + Mg2+ is inhibited by a variety of structurally unrelated inhibitors.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1994;72(11-12):631-8.
1994: Richard D Verschoyle; P Carthew; Lake Jean Holley; P Cullis; Gerald M Cohen
The comparative toxicity of chlorambucil and chlorambucil-spermidine conjugate to BALB/c mice.
Cancer letters 1994;85(2):217-22.
1994: J T Wolfe; D Ross; Gerald M Cohen
A role for metals and free radicals in the induction of apoptosis in thymocytes.
FEBS letters 1994;352(1):58-62.
1994: Howard Fearnhead; M Chwalinski; R T Snowden; M G Ormerod; Gerald M Cohen
Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle.
Biochemical pharmacology 1994;48(6):1073-9.
1994: Xiao-Ming Sun; P Carthew; David Dinsdale; R T Snowden; Gerald M Cohen
The involvement of apoptosis in etoposide-induced thymic atrophy.
Toxicology and applied pharmacology 1994;128(1):78-85.
1994: C Norbury; M MacFarlane; Howard Fearnhead; Gerald M Cohen
Cdc2 activation is not required for thymocyte apoptosis.
Biochemical and biophysical research communications 1994;202(3):1400-6.
1994: Kelvin Cain; Salmaan H Inayat-Hussain; J T Wolfe; Gerald M Cohen
DNA fragmentation into 200-250 and/or 30-50 kilobase pair fragments in rat liver nuclei is stimulated by Mg2+ alone and Ca2+/Mg2+ but not by Ca2+ alone.
FEBS letters 1994;349(3):385-91.
1994: Gerald M Cohen; Xiao-Ming Sun; Howard Fearnhead; Marion MacFarlane; D G Brown; R T Snowden; David Dinsdale
Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(2):507-16.
1994: Xiao-Ming Sun; Gerald M Cohen
Mg(2+)-dependent cleavage of DNA into kilobase pair fragments is responsible for the initial degradation of DNA in apoptosis.
The Journal of biological chemistry 1994;269(21):14857-60.
1994: Xiao-Ming Sun; R T Snowden; David Dinsdale; M G Ormerod; Gerald M Cohen
Changes in nuclear chromatin precede internucleosomal DNA cleavage in the induction of apoptosis by etoposide.
Biochemical pharmacology 1994;47(2):187-95.
1993: M Butterworth; D G Upshall; Gerald M Cohen
A novel role for carboxylesterase in the elevation of cellular cysteine by esters of cysteine.
Biochemical pharmacology 1993;46(7):1131-7.
1993: Gerald M Cohen; Xiao-Ming Sun; R T Snowden; M G Ormerod; David Dinsdale
Identification of a transitional preapoptotic population of thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(2):566-74.
1993: M Butterworth; D G Upshall; M Hobbs; Gerald M Cohen
Elevation of cysteine and replenishment of glutathione in rat lung slices by cysteine isopropylester and other cysteine precursors.
Biochemical pharmacology 1993;45(9):1769-74.
1993: M J Hobbs; M Butterworth; Gerald M Cohen; D G Upshall
Structure-activity relationships of cysteine esters and their effects on thiol levels in rat lung in vitro.
Biochemical pharmacology 1993;45(8):1605-12.
1993: M Raffray; D McCarthy; R T Snowden; Gerald M Cohen
Apoptosis as a mechanism of tributyltin cytotoxicity to thymocytes: relationship of apoptotic markers to biochemical and cellular effects.
Toxicology and applied pharmacology 1993;119(1):122-30.
1993: D G Brown; X M Sun; Gerald M Cohen
Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation.
The Journal of biological chemistry 1993;268(5):3037-9.
1993: M Raffray; Gerald M Cohen
Thymocyte apoptosis as a mechanism for tributyltin-induced thymic atrophy in vivo.
Archives of toxicology 1993;67(4):231-6.
1993: M G Ormerod; Xiao-Ming Sun; R T Snowden; R Davies; Howard Fearnhead; Gerald M Cohen
Increased membrane permeability of apoptotic thymocytes: a flow cytometric study.
Cytometry 1993;14(6):595-602.
1993: M G Ormerod; Xiao-Ming Sun; D Brown; R T Snowden; Gerald M Cohen
Quantification of apoptosis and necrosis by flow cytometry.
Acta oncologica (Stockholm, Sweden) 1993;32(4):417-24.
1992: Xiao-Ming Sun; David Dinsdale; R T Snowden; Gerald M Cohen; D N Skilleter
Characterization of apoptosis in thymocytes isolated from dexamethasone-treated rats.
Biochemical pharmacology 1992;44(11):2131-7.
1992: Gerald M Cohen; Xiao-Ming Sun; R T Snowden; David Dinsdale; D N Skilleter
Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation.
The Biochemical journal 1992;286 ( Pt 2)():331-4.
1992: Lake Jean Holley; A Mather; R T Wheelhouse; P M Cullis; John A Hartley; J P Bingham; Gerald M Cohen
Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate.
Cancer research 1992;52(15):4190-5.
1992: Xiao-Ming Sun; R T Snowden; D N Skilleter; David Dinsdale; M G Ormerod; Gerald M Cohen
A flow-cytometric method for the separation and quantitation of normal and apoptotic thymocytes.
Analytical biochemistry 1992;204(2):351-6.
1992: W A Morgan; J A Hartley; Gerald M Cohen
Quinone-induced DNA single strand breaks in rat hepatocytes and human chronic myelogenous leukaemic K562 cells.
Biochemical pharmacology 1992;44(2):215-21.
1992: Lake Jean Holley; A Mather; P Cullis; M R Symons; P Wardman; R A Watt; Gerald M Cohen
Uptake and cytotoxicity of novel nitroimidazole-polyamine conjugates in Ehrlich ascites tumour cells.
Biochemical pharmacology 1992;43(4):763-9.
1992: M Butterworth; D G Upshall; L L Smith; Gerald M Cohen
Cysteine isopropylester protects against paracetamol-induced toxicity.
Biochemical pharmacology 1992;43(3):483-8.
1991: S J Hardwick; J T Skamarauskas; L L Smith; D G Upshall; Gerald M Cohen
Protection of rats against the effects of alpha-naphthylthiourea (ANTU) by elevation of non-protein sulphydryl levels.
Biochemical pharmacology 1991;42(6):1203-8.
1991: M Raffray; Gerald M Cohen
Bis(tri-n-butyltin)oxide induces programmed cell death (apoptosis) in immature rat thymocytes.
Archives of toxicology 1991;65(2):135-9.
1990: A Adam; L L Smith; Gerald M Cohen
An evaluation of the redox cycling potencies of paraquat and nitrofurantoin in microsomal and lung slice systems.
Biochemical pharmacology 1990;40(7):1533-9.
1990: Gerald M Cohen; L L Smith
Potential therapeutic exploitation of the pulmonary polyamine uptake system.
Biochemical Society transactions 1990;18(5):743-5.
1990: A Adam; L L Smith; Gerald M Cohen
An assessment of the role of redox cycling in mediating the toxicity of paraquat and nitrofurantoin.
Environmental health perspectives 1990;85():113-7.
1990: Gerald M Cohen
Pulmonary metabolism of foreign compounds: its role in metabolic activation.
Environmental health perspectives 1990;85():31-41.
1990: S J Hardwick; A Adam; L L Smith; Gerald M Cohen
A novel lung slice system with compromised antioxidant defenses.
Environmental health perspectives 1990;85():129-33.
1990: S J Hardwick; A Adam; L L Smith; Gerald M Cohen
Potentiation of the cell specific toxicity of paraquat by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Implications for the heterogeneous distribution of glutathione (GSH) in rat lung.
Biochemical pharmacology 1990;39(3):581-9.
1990: Gerald M Cohen; C R Stubberfield
Pyridine nucleotide changes in hepatocytes exposed to quinones.
Free radical research communications 1990;8(4-6):355-63.
1989: C R Stubberfield; Gerald M Cohen
Interconversion of NAD(H) to NADP(H). A cellular response to quinone-induced oxidative stress in isolated hepatocytes.
Biochemical pharmacology 1989;38(16):2631-7.
1988: C R Stubberfield; Gerald M Cohen
NAD+ depletion and cytotoxicity in isolated hepatocytes.
Biochemical pharmacology 1988;37(20):3967-74.
1988: T W Gant; D N Rao; R P Mason; Gerald M Cohen
Redox cycling and sulphydryl arylation; their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes.
Chemico-biological interactions 1988;65(2):157-73.
1987: K A O'Brien; L L Smith; Gerald M Cohen
Inability of a human lung tumour cell line (A549) to detect chemically induced organ-specific toxicity to the lung.
Toxicology in vitro : an international journal published in association with BIBRA 1987;1(2):85-90.