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Philip Cohen

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Phenomena

Phosphorylation

Genes & Molecular Sequences

Amino Acid Sequence

Concepts & Ideas

Chemicals & Drugs

Physiology

Enzyme Activation

Living Beings

Anatomy

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Co-Publications
Name
23
Morrice, Nick
22
Goedert, Michel
21
Alessi, Dario
20
Peggie, Mark
14
Cohen, Patricia
14
Cuenda, Ana
10
Campbell, David
8
Jakes, Ross
8
MacKintosh, Carol
7
Smythe, Carl
7
Rousseau, Simon
7
Knebel, Axel
7
Arthur, Simon
5
Bain, Jenny
5
Armstrong, Christopher

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Publications

TOP 3
Handoyo Hosea; Stafford Margaret J; McManus Eamon; Baltzis Dionissios; Peggie Mark; Cohen Philip
IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.
Clark Kristopher; Plater Lorna; Peggie Mark; Cohen Philip
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.
Yang Huei-Ting; Peggie Mark; Cohen Philip; Rousseau Simon
DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins.

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All Publications

2009: Handoyo Hosea; Stafford Margaret J; McManus Eamon; Baltzis Dionissios; Peggie Mark; Cohen Philip
IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.
The Biochemical journal 2009;424(1):109-18.
2009: Clark Kristopher; Plater Lorna; Peggie Mark; Cohen Philip
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.
The Journal of biological chemistry 2009;284(21):14136-46.
2009: Yang Huei-Ting; Peggie Mark; Cohen Philip; Rousseau Simon
DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins.
Biochemical and biophysical research communications 2009;380(3):705-9.
2009: Smith Hilary; Peggie Mark; Campbell David G; Vandermoere Franck; Carrick Emma; Cohen Philip
Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(12):4584-90.
2009: Klevernic Iva V; Morton Simon; Davis Roger J; Cohen Philip
Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage.
The Biochemical journal 2009;418(3):625-34.
2009: Klevernic Iva V; Martin Niall M B; Cohen Philip
Regulation of the activity and expression of ERK8 by DNA damage.
FEBS letters 2009;583(4):680-4.
2008: Morton Simon; Hesson Luke; Peggie Mark; Cohen Philip
Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma.
FEBS letters 2008;582(6):997-1002.
2008: Windheim Mark; Stafford Margaret; Peggie Mark; Cohen Philip
Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase.
Molecular and cellular biology 2008;28(5):1783-91.
2008: Yang Huei-Ting; Cohen Philip; Rousseau Simon
IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells.
Cellular signalling 2008;20(2):375-80.
2008: Windheim Mark; Peggie Mark; Cohen Philip
Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.
The Biochemical journal 2008;409(3):723-9.
2008: Mendoza Heidi; Campbell David G; Burness Kerry; Hastie James; Ronkina Natalia; Shim Jae-Hyuck; Arthur J Simon C; Davis Roger J; Gaestel Matthias; Johnson Gary L; Ghosh Sankar; Cohen Philip
Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.
The Biochemical journal 2008;409(3):711-22.
2008: Rousseau Simon; Papoutsopoulou Matoula; Symons Antony; Cook Dorthe; Lucocq John M; Prescott Alan R; O'Garra Anne; Ley Steven C; Cohen Philip
TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages.
Journal of cell science 2008;121(Pt 2):149-54.
2008: Ordureau Alban; Smith Hilary; Windheim Mark; Peggie Mark; Carrick Emma; Morrice Nick; Cohen Philip
The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.
The Biochemical journal 2008;409(1):43-52.
2007: Bain Jenny; Plater Lorna; Elliott Matt; Shpiro Natalia; Hastie C James; McLauchlan Hilary; Klevernic Iva; Arthur J Simon C; Alessi Dario R; Cohen Philip
The selectivity of protein kinase inhibitors: a further update.
The Biochemical journal 2007;408(3):297-315.
2007: Windheim Mark; Lang Christine; Peggie Mark; Plater Lorna A; Cohen Philip
Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide.
The Biochemical journal 2007;404(2):179-90.
2007: Cuadrado Ana; Lafarga Vanesa; Cheung Peter C F; Dolado Ignacio; Llanos Susana; Cohen Philip; Nebreda Angel R
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis.
The EMBO journal 2007;26(8):2115-26.
2007: Sapkota Gopal P; Cummings Lorna; Newell Felicity S; Armstrong Christopher; Bain Jennifer; Frodin Morten; Grauert Matthias; Hoffmann Matthias; Schnapp Gisela; Steegmaier Martin; Cohen Philip; Alessi Dario R
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.
The Biochemical journal 2007;401(1):29-38.
2006: Cohen Philip
The twentieth century struggle to decipher insulin signalling.
Nature reviews. Molecular cell biology 2006;7(11):867-73.
2006: Conner Sarah H; Kular Gursant; Peggie Mark; Shepherd Sharon; Schüttelkopf Alexander W; Cohen Philip; Van Aalten Daan M F
TAK1-binding protein 1 is a pseudophosphatase.
The Biochemical journal 2006;399(3):427-34.
2006: Rousseau Simon; Dolado Ignacio; Beardmore Victoria; Shpiro Natalia; Marquez Rudolfo; Nebreda Angel R; Arthur J Simon C; Case Lauren M; Tessier-Lavigne Marc; Gaestel Matthias; Cuenda Ana; Cohen Philip
CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway.
Cellular signalling 2006;18(11):1897-905.
2006: Morton Simon; Yang Huei-Ting; Moleleki Ntsane; Campbell David G; Cohen Philip; Rousseau Simon
Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ.
The Biochemical journal 2006;399(2):265-73.
2006: Stafford Margaret J; Morrice Nick A; Peggie Mark W; Cohen Philip
Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.
FEBS letters 2006;580(16):4010-4.
2006: Klevernic Iva V; Stafford Margaret J; Morrice Nicholas; Peggie Mark; Morton Simon; Cohen Philip
Characterization of the reversible phosphorylation and activation of ERK8.
The Biochemical journal 2006;394(Pt 1):365-73.
2006: Cohen Philip; Knebel Axel
KESTREL: a powerful method for identifying the physiological substrates of protein kinases.
The Biochemical journal 2006;393(Pt 1):1-6.
2005: Zhang Minghao; Windheim Mark; Roe S Mark; Peggie Mark; Cohen Philip; Prodromou Chrisostomos; Pearl Laurence H
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.
Molecular cell 2005;20(4):525-38.
2005: Rousseau Simon; Peggie Mark; Campbell David G; Nebreda Angel R; Cohen Philip
Nogo-B is a new physiological substrate for MAPKAP-K2.
The Biochemical journal 2005;391(Pt 2):433-40.
2005: Auld Gillian C; Campbell David G; Morrice Nick; Cohen Philip
Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL.
The Biochemical journal 2005;389(Pt 3):775-83.
2005: Eyers Claire E; McNeill Helen; Knebel Axel; Morrice Nick; Arthur Simon J C; Cuenda Ana; Cohen Philip
The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.
The Biochemical journal 2005;389(Pt 1):127-35.
2005: Cartlidge Robert A; Knebel Axel; Peggie Mark; Alexandrov Andrei; Phizicky Eric M; Cohen Philip
The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.
The EMBO journal 2005;24(9):1696-705.
2005: Murray James T; Cummings Lorna A; Bloomberg Graham B; Cohen Philip
Identification of different specificity requirements between SGK1 and PKBalpha.
FEBS letters 2005;579(5):991-4.
2004: Murray James T; Campbell David G; Morrice Nicholas; Auld Gillian C; Shpiro Natalia; Marquez Rodolpho; Peggie Mark; Bain Jenny; Bloomberg Graham B; Grahammer Florian; Lang Florian; Wulff Peer; Kuhl Dietmar; Cohen Philip
Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3.
The Biochemical journal 2004;384(Pt 3):477-88.
2004: Murray James T; Campbell David G; Peggie Mark; Mora Alfonso; Cohen Philip
Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL.
The Biochemical journal 2004;384(Pt 3):489-94.
2004: McNeill Helen; Knebel Axel; Arthur J Simon C; Cuenda Ana; Cohen Philip
A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs.
The Biochemical journal 2004;384(Pt 2):391-400.
2004: Morton Simon; Davis Roger J; Cohen Philip
Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2.
FEBS letters 2004;572(1-3):177-83.
2004: Cohen Philip
Philip Cohen.
Current biology : CB 2004;14(15):R597-8.
2004: Yoshida Hirotaka; Hastie C James; McLauchlan Hilary; Cohen Philip; Goedert Michel
Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK).
Journal of neurochemistry 2004;90(2):352-8.
2004: Cohen Philip; Goedert Michel
GSK3 inhibitors: development and therapeutic potential.
Nature reviews. Drug discovery 2004;3(6):479-87.
2004: Cheung Peter C F; Nebreda Angel R; Cohen Philip
TAB3, a new binding partner of the protein kinase TAK1.
The Biochemical journal 2004;378(Pt 1):27-34.
2004: Rena Graham; Bain Jenny; Elliott Matthew; Cohen Philip
D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.
EMBO reports 2004;5(1):60-5.
2004: Cole Adam; Frame Sheelagh; Cohen Philip
Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event.
The Biochemical journal 2004;377(Pt 1):249-55.
2003: Cheung Peter C F; Campbell David G; Nebreda Angel R; Cohen Philip
Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha.
The EMBO journal 2003;22(21):5793-805.
2003: Morton Simon; Davis Roger J; McLaren Ann; Cohen Philip
A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun.
The EMBO journal 2003;22(15):3876-86.
2003: Mody Nimesh; Campbell David G; Morrice Nick; Peggie Mark; Cohen Philip
An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro.
The Biochemical journal 2003;372(Pt 2):567-75.
2003: Bain Jenny; McLauchlan Hilary; Elliott Matthew; Cohen Philip
The specificities of protein kinase inhibitors: an update.
The Biochemical journal 2003;371(Pt 1):199-204.
2002: Rousseau Simon; Morrice Nick; Peggie Mark; Campbell David G; Gaestel Matthias; Cohen Philip
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.
The EMBO journal 2002;21(23):6505-14.
2002: Knebel Axel; Haydon Claire E; Morrice Nick; Cohen Philip
Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.
The Biochemical journal 2002;367(Pt 2):525-32.
2002: Velasco Guillermo; Armstrong Chris; Morrice Nick; Frame Sheelagh; Cohen Philip
Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin.
FEBS letters 2002;527(1-3):101-4.
2002: Ross Heike; Armstrong Christopher G; Cohen Philip
A non-radioactive method for the assay of many serine/threonine-specific protein kinases.
The Biochemical journal 2002;366(Pt 3):977-81.
2002: Cohen Philip
The origins of protein phosphorylation.
Nature cell biology 2002;4(5):E127-30.
2002: Rena Graham; Woods Yvonne L; Prescott Alan R; Peggie Mark; Unterman Terry G; Williams Michayla R; Cohen Philip
Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.
The EMBO journal 2002;21(9):2263-71.
2002: Cohen Philip
Protein kinases--the major drug targets of the twenty-first century?
Nature reviews. Drug discovery 2002;1(4):309-15.
2002: Wiggin Giselle R; Soloaga Ana; Foster Julia M; Murray-Tait Victoria; Cohen Philip; Arthur J Simon C
MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.
Molecular and cellular biology 2002;22(8):2871-81.
2002: Trotter Linda; Panton Wendy; Hajimohamadreza Iradj; Petalidis Lawrence; Ward Robin; Fleming Yvonne; Armstrong Christopher G; Cohen Philip; Karran Eric H; Kinloch Ross A
Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons.
Neuroscience letters 2002;320(1-2):29-32.
2002: Haydon Claire E; Watt Peter W; Morrice Nick; Knebel Axel; Gaestel Matthias; Cohen Philip
Identification of a phosphorylation site on skeletal muscle myosin light chain kinase that becomes phosphorylated during muscle contraction.
Archives of biochemistry and biophysics 2002;397(2):224-31.
2002: Fagerholm Susanna; Morrice Nick; Gahmberg Carl G; Cohen Philip
Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes.
The Journal of biological chemistry 2002;277(3):1728-38.
2001: Caivano M; Gorgoni B; Cohen P; Poli V
The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta ) and C/EBP delta transcription factors.
The Journal of biological chemistry 2001;276(52):48693-701.
2001: Cohen P
The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture.
European journal of biochemistry / FEBS 2001;268(19):5001-10.
2001: Cohen P; Frame S
The renaissance of GSK3.
Nature reviews. Molecular cell biology 2001;2(10):769-76.
2001: Frame S; Cohen P
GSK3 takes centre stage more than 20 years after its discovery.
The Biochemical journal 2001;359(Pt 1):1-16.
2001: Knebel A; Morrice N; Cohen P
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.
The EMBO journal 2001;20(16):4360-9.
2001: Mody N; Leitch J; Armstrong C; Dixon J; Cohen P
Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway.
FEBS letters 2001;502(1-2):21-4.
2001: Frame S; Cohen P; Biondi R M
A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation.
Molecular cell 2001;7(6):1321-7.
2001: Woods Y L; Cohen P; Becker W; Jakes R; Goedert M; Wang X; Proud C G
The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.
The Biochemical journal 2001;355(Pt 3):609-15.
2001: Woods Y L; Rena G; Morrice N; Barthel A; Becker W; Guo S; Unterman T G; Cohen P
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.
The Biochemical journal 2001;355(Pt 3):597-607.
2001: Cheung P C; Trinkle-Mulcahy L; Cohen P; Lucocq J M
Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi.
The Biochemical journal 2001;355(Pt 1):113-21.
2001: Rena G; Prescott A R; Guo S; Cohen P; Unterman T G
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.
The Biochemical journal 2001;354(Pt 3):605-12.
2001: Fagerholm S C; Prescott A; Cohen P; Gahmberg C G
An essential role for calmodulin in regulating human T cell aggregation.
FEBS letters 2001;491(1-2):131-6.
2000: Hefner Y; Borsch-Haubold A G; Murakami M; Wilde J I; Pasquet S; Schieltz D; Ghomashchi F; Yates J R; Armstrong C G; Paterson A; Cohen P; Fukunaga R; Hunter T; Kudo I; Watson S P; Gelb M H
Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.
The Journal of biological chemistry 2000;275(48):37542-51.
2000: Fleming Y; Armstrong C G; Morrice N; Paterson A; Goedert M; Cohen P
Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.
The Biochemical journal 2000;352 Pt 1():145-54.
2000: Davies S P; Reddy H; Caivano M; Cohen P
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
The Biochemical journal 2000;351(Pt 1):95-105.
2000: Arthur J S; Cohen P
MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells.
FEBS letters 2000;482(1-2):44-8.
2000: Lizcano J M; Morrice N; Cohen P
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
The Biochemical journal 2000;349(Pt 2):547-57.
2000: Williams M R; Arthur J S; Balendran A; van der Kaay J; Poli V; Cohen P; Alessi D R
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.
Current biology : CB 2000;10(8):439-48.
2000: Caivano M; Cohen P
Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3018-25.
2000: Walker K S; Watt P W; Cohen P
Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivo.
FEBS letters 2000;466(1):121-4.
1999: Chang A C; Sohlberg B; Trinkle-Mulcahy L; Claverie-Martin F; Cohen P; Cohen S N
Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene.
Gene 1999;240(1):45-55.
1999: Shaw M; Cohen P
Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells.
FEBS letters 1999;461(1-2):120-4.
1999: Kobayashi T; Deak M; Morrice N; Cohen P
Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.
The Biochemical journal 1999;344 Pt 1():189-97.
1999: Börsch-Haubold A G; Ghomashchi F; Pasquet S; Goedert M; Cohen P; Gelb M H; Watson S P
Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways.
European journal of biochemistry / FEBS 1999;265(1):195-203.
1999: Thomas G M; Frame S; Goedert M; Nathke I; Polakis P; Cohen P
A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin.
FEBS letters 1999;458(2):247-51.
1999: Hall-Jackson C A; Eyers P A; Cohen P; Goedert M; Boyle F T; Hewitt N; Plant H; Hedge P
Paradoxical activation of Raf by a novel Raf inhibitor.
Chemistry & biology 1999;6(8):559-68.
1999: Rena G; Guo S; Cichy S C; Unterman T G; Cohen P
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.
The Journal of biological chemistry 1999;274(24):17179-83.
1999: Eyers P A; van den IJssel P; Quinlan R A; Goedert M; Cohen P
Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580.
FEBS letters 1999;451(2):191-6.
1999: Hasegawa M; Cuenda A; Spillantini M G; Thomas G M; Buée-Scherrer V; Cohen P; Goedert M
Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.
The Journal of biological chemistry 1999;274(18):12626-31.
1999: Kobayashi T; Cohen P
Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.
The Biochemical journal 1999;339 ( Pt 2)():319-28.
1999: Hall-Jackson C A; Goedert M; Hedge P; Cohen P
Effect of SB 203580 on the activity of c-Raf in vitro and in vivo.
Oncogene 1999;18(12):2047-54.
1999: Cohen P
The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1382):485-95.
1999: Cuenda A; Cohen P
Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis.
The Journal of biological chemistry 1999;274(7):4341-6.
1999: Currie R A; Walker K S; Gray A; Deak M; Casamayor A; Downes C P; Cohen P; Alessi D R; Lucocq J
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
The Biochemical journal 1999;337 ( Pt 3)():575-83.
1999: Trinkle-Mulcahy L; Ajuh P; Prescott A; Claverie-Martin F; Cohen S; Lamond A I; Cohen P
Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors.
Journal of cell science 1999;112 ( Pt 2)():157-68.
1998: Lawler S; Fleming Y; Goedert M; Cohen P
Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro.
Current biology : CB 1998;8(25):1387-90.
1998: Moorhead G; Johnson D; Morrice N; Cohen P
The major myosin phosphatase in skeletal muscle is a complex between the beta-isoform of protein phosphatase 1 and the MYPT2 gene product.
FEBS letters 1998;438(3):141-4.
1998: Shaw M; Cohen P; Alessi D R
The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2.
The Biochemical journal 1998;336 ( Pt 1)():241-6.
1998: Doza Y N; Hall-Jackson C A; Cohen P
Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos.
Oncogene 1998;17(1):19-24.
1998: Cohen P; Goedert M
Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid.
Chemistry & biology 1998;5(7):R161-4.
1998: Eyers P A; Craxton M; Morrice N; Cohen P; Goedert M
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution.
Chemistry & biology 1998;5(6):321-8.
1998: Walker K S; Deak M; Paterson A; Hudson K; Cohen P; Alessi D R
Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.
The Biochemical journal 1998;331 ( Pt 1)():299-308.
1998: Cohen P
The Department of Biochemistry at the University of Dundee.
Molecular medicine (Cambridge, Mass.) 1998;4(2):65-9.
1998: Alessi D R; Cohen P
Mechanism of activation and function of protein kinase B.
Current opinion in genetics & development 1998;8(1):55-62.
1998: Dalby K N; Morrice N; Caudwell F B; Avruch J; Cohen P
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK.
The Journal of biological chemistry 1998;273(3):1496-505.
1997: Thomas G M; Haavik J; Cohen P
A stress-activated kinase cascade can mediate the activation of tyrosine hydroxylase in chromaffin cells.
Biochemical Society transactions 1997;25(4):S571.
1997: Cuenda A; Goedert M; Craxton M; Jakes R; Cohen P
Activation of the novel MAP kinase homologue SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6).
Biochemical Society transactions 1997;25(4):S569.
1997: Armstrong C G; Browne G J; Cohen P; Cohen P T
PPP1R6, a novel member of the family of glycogen-targetting subunits of protein phosphatase 1.
FEBS letters 1997;418(1-2):210-4.
1997: Shaw M; Cohen P; Alessi D R
Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216.
FEBS letters 1997;416(3):307-11.
1997: Lawler S; Cuenda A; Goedert M; Cohen P
SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK).
FEBS letters 1997;414(1):153-8.
1997: Thomas G; Haavik J; Cohen P
Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells.
European journal of biochemistry / FEBS 1997;247(3):1180-9.
1997: Cohen P; Alessi D R; Cross D A
PDK1, one of the missing links in insulin signal transduction?
FEBS letters 1997;410(1):3-10.
1997: Goedert M; Cuenda A; Craxton M; Jakes R; Cohen P
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.
The EMBO journal 1997;16(12):3563-71.
1997: Goedert M; Hasegawa M; Jakes R; Lawler S; Cuenda A; Cohen P
Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases.
FEBS letters 1997;409(1):57-62.
1997: Egloff M P; Johnson D F; Moorhead G; Cohen P T; Cohen P; Barford D
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1.
The EMBO journal 1997;16(8):1876-87.
1997: Cross D A; Watt P W; Shaw M; van der Kaay J; Downes C P; Holder J C; Cohen P
Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue.
FEBS letters 1997;406(1-2):211-5.
1997: Alessi D R; James S R; Downes C P; Holmes A B; Gaffney P R; Reese C B; Cohen P
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
Current biology : CB 1997;7(4):261-9.
1997: Johnson D; Cohen P; Chen M X; Chen Y H; Cohen P T
Identification of the regions on the M110 subunit of protein phosphatase 1M that interact with the M21 subunit and with myosin.
European journal of biochemistry / FEBS 1997;244(3):931-9.
1997: Cuenda A; Cohen P; Buée-Scherrer V; Goedert M
Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38).
The EMBO journal 1997;16(2):295-305.
1996: Alessi D R; Caudwell F B; Andjelkovic M; Hemmings B A; Cohen P
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase.
FEBS letters 1996;399(3):333-8.
1996: Alessi D R; Andjelkovic M; Caudwell B; Cron P; Morrice N; Cohen P; Hemmings B A
Mechanism of activation of protein kinase B by insulin and IGF-1.
The EMBO journal 1996;15(23):6541-51.
1996: MacKintosh C; Garton A J; McDonnell A; Barford D; Cohen P T; Tonks N K; Cohen P
Further evidence that inhibitor-2 acts like a chaperone to fold PP1 into its native conformation.
FEBS letters 1996;397(2-3):235-8.
1996: Clifton A D; Young P R; Cohen P
A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.
FEBS letters 1996;392(3):209-14.
1996: Cuenda A; Alonso G; Morrice N; Jones M; Meier R; Cohen P; Nebreda A R
Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells.
The EMBO journal 1996;15(16):4156-64.
1996: Johnson D F; Moorhead G; Caudwell F B; Cohen P; Chen Y H; Chen M X; Cohen P T
Identification of protein-phosphatase-1-binding domains on the glycogen and myofibrillar targetting subunits.
European journal of biochemistry / FEBS 1996;239(2):317-25.
1996: Gordon R D; Leighton I A; Campbell D G; Cohen P; Creaney A; Wilton D C; Masters D J; Ritchie G A; Mott R; Taylor I W; Bundell K R; Douglas L; Morten J; Needham M
Cloning and expression of cystolic phospholipase A2 (cPLA2) and a naturally occurring variant. Phosphorylation of Ser505 of recombinant cPLA2 by p42 mitogen-activated protein kinase results in an increase in specific activity.
European journal of biochemistry / FEBS 1996;238(3):690-7.
1996: Meier R; Rouse J; Cuenda A; Nebreda A R; Cohen P
Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells.
European journal of biochemistry / FEBS 1996;236(3):796-805.
1996: Cohen P
Dissection of protein kinase cascades that mediate cellular response to cytokines and cellular stress.
Advances in pharmacology (San Diego, Calif.) 1996;36():15-27.
1995: Cross D A; Alessi D R; Cohen P; Andjelkovich M; Hemmings B A
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
Nature 1995;378(6559):785-9.
1995: Baxter R M; Cohen P; Obermeier A; Ullrich A; Downes C P; Doza Y N
Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells.
European journal of biochemistry / FEBS 1995;234(1):84-91.
1995: Alessi D R; Cuenda A; Cohen P; Dudley D T; Saltiel A R
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.
The Journal of biological chemistry 1995;270(46):27489-94.
1995: Doherty M J; Moorhead G; Morrice N; Cohen P; Cohen P T
Amino acid sequence and expression of the hepatic glycogen-binding (GL)-subunit of protein phosphatase-1.
FEBS letters 1995;375(3):294-8.
1995: Leighton I A; Dalby K N; Caudwell F B; Cohen P T; Cohen P
Comparison of the specificities of p70 S6 kinase and MAPKAP kinase-1 identifies a relatively specific substrate for p70 S6 kinase: the N-terminal kinase domain of MAPKAP kinase-1 is essential for peptide phosphorylation.
FEBS letters 1995;375(3):289-93.
1995: MacKintosh R W; Dalby K N; Campbell D G; Cohen P T; Cohen P; MacKintosh C
The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1.
FEBS letters 1995;371(3):236-40.
1995: Cuenda A; Rouse J; Doza Y N; Meier R; Cohen P; Gallagher T F; Young P R; Lee J C
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.
FEBS letters 1995;364(2):229-33.
1995: Doza Y N; Cuenda A; Thomas G M; Cohen P; Nebreda A R
Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.
FEBS letters 1995;364(2):223-8.
1995: Goedert M; Spillantini M G; Jakes R; Crowther R A; Vanmechelen E; Probst A; Götz J; Bürki K; Cohen P
Molecular dissection of the paired helical filament.
Neurobiology of aging 1995;16(3):325-34.
1995: Moorhead G; MacKintosh C; Morrice N; Cohen P
Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography.
FEBS letters 1995;362(2):101-5.
1995: Alessi D R; Gomez N; Moorhead G; Lewis T; Keyse S M; Cohen P
Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines.
Current biology : CB 1995;5(3):283-95.
1995: Goedert M; Jakes R; Spillantini M G; Crowther R A; Cohen P; Vanmechelen E; Probst A; Götz J; Bürki K
Tau protein in Alzheimer's disease.
Biochemical Society transactions 1995;23(1):80-5.
1995: Alessi D R; Cohen P; Ashworth A; Cowley S; Leevers S J; Marshall C J
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf.
Methods in enzymology 1995;255():279-90.
1994: Chen Y H; Chen M X; Alessi D R; Campbell D G; Shanahan C; Cohen P; Cohen P T
Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M.
FEBS letters 1994;356(1):51-5.
1994: Saito Y; Vandenheede J R; Cohen P
The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells.
The Biochemical journal 1994;303 ( Pt 1)():27-31.
1994: Cross D A; Alessi D R; Vandenheede J R; McDowell H E; Hundal H S; Cohen P
The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf.
The Biochemical journal 1994;303 ( Pt 1)():21-6.
1994: Rouse J; Cohen P; Trigon S; Morange M; Alonso-Llamazares A; Zamanillo D; Hunt T; Nebreda A R
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins.
Cell 1994;78(6):1027-37.
1994: Traverse S; Cohen P
Identification of a latent MAP kinase kinase kinase in PC12 cells as B-raf.
FEBS letters 1994;350(1):13-8.
1994: Traverse S; Seedorf K; Paterson H; Marshall C J; Cohen P; Ullrich A
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor.
Current biology : CB 1994;4(8):694-701.
1994: Goedert M; Jakes R; Crowther R A; Cohen P; Vanmechelen E; Vandermeeren M; Cras P
Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein.
The Biochemical journal 1994;301 ( Pt 3)():871-7.
1994: Alessi D R; Saito Y; Campbell D G; Cohen P; Sithanandam G; Rapp U; Ashworth A; Marshall C J; Cowley S
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
The EMBO journal 1994;13(7):1610-9.
1994: Saito Y; Gomez N; Campbell D G; Ashworth A; Marshall C J; Cohen P
The threonine residues in MAP kinase kinase 1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor-stimulated rat phaeochromocytoma (PC12) cells.
FEBS letters 1994;341(1):119-24.
1994: Sutherland C; Cohen P
The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro.
FEBS letters 1994;338(1):37-42.
1993: Stokoe D; Caudwell B; Cohen P T; Cohen P
The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.
The Biochemical journal 1993;296 ( Pt 3)():843-9.
1993: Clarke P R; Siddhanti S R; Cohen P; Blackshear P J
Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate.
FEBS letters 1993;336(1):37-42.
1993: Traverse S; Cohen P; Paterson H; Marshall C; Rapp U; Grand R J
Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.
Oncogene 1993;8(11):3175-81.
1993: Sutherland C; Leighton I A; Cohen P
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.
The Biochemical journal 1993;296 ( Pt 1)():15-9.
1993: Leighton I A; Curmi P; Campbell D G; Cohen P; Sobel A
The phosphorylation of stathmin by MAP kinase.
Molecular and cellular biochemistry 1993;127-128():151-6.
1993: Sutherland C; Alterio J; Campbell D G; Le Bourdellès B; Mallet J; Haavik J; Cohen P
Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2.
European journal of biochemistry / FEBS 1993;217(2):715-22.
1993: Cohen P
Dissection of the protein phosphorylation cascades involved in insulin and growth factor action.
Biochemical Society transactions 1993;21 ( Pt 3)(3):555-67.
1993: Ferrigno P; Langan T A; Cohen P
Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases.
Molecular biology of the cell 1993;4(7):669-77.
1993: Alessi D R; Street A J; Cohen P; Cohen P T
Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme.
European journal of biochemistry / FEBS 1993;213(3):1055-66.
1993: Sutherland C; Campbell D G; Cohen P
Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase.
European journal of biochemistry / FEBS 1993;212(2):581-8.
1992: Gomez N; Traverse S; Cohen P
Identification of a MAP kinase kinase kinase in phaeochromocytoma (PC12) cells.
FEBS letters 1992;314(3):461-5.
1992: Ashworth A; Nakielny S; Cohen P; Marshall C
The amino acid sequence of a mammalian MAP kinase kinase.
Oncogene 1992;7(12):2555-6.
1992: Dent P; MacDougall L K; MacKintosh C; Campbell D G; Cohen P
A myofibrillar protein phosphatase from rabbit skeletal muscle contains the beta isoform of protein phosphatase-1 complexed to a regulatory subunit which greatly enhances the dephosphorylation of myosin.
European journal of biochemistry / FEBS 1992;210(3):1037-44.
1992: Alessi D; MacDougall L K; Sola M M; Ikebe M; Cohen P
The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1.
European journal of biochemistry / FEBS 1992;210(3):1023-35.
1992: Traverse S; Gomez N; Paterson H; Marshall C; Cohen P
Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor.
The Biochemical journal 1992;288 ( Pt 2)():351-5.
1992: Stokoe D; Engel K; Campbell D G; Cohen P; Gaestel M
Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.
FEBS letters 1992;313(3):307-13.
1992: Goedert M; Cohen E S; Jakes R; Cohen P
p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected]
FEBS letters 1992;312(1):95-9.
1992: Stokoe D; Campbell D G; Nakielny S; Hidaka H; Leevers S J; Marshall C; Cohen P
MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.
The EMBO journal 1992;11(11):3985-94.
1992: Cohen P
Signal integration at the level of protein kinases, protein phosphatases and their substrates.
Trends in biochemical sciences 1992;17(10):408-13.
1992: Howe L R; Leevers S J; Gómez N; Nakielny S; Cohen P; Marshall C J
Activation of the MAP kinase pathway by the protein kinase raf.
Cell 1992;71(2):335-42.
1992: Nakielny S; Campbell D G; Cohen P
MAP kinase kinase from rabbit skeletal muscle. A novel dual specificity enzyme showing homology to yeast protein kinases involved in pheromone-dependent signal transduction.
FEBS letters 1992;308(2):183-9.
1992: Cohen P; Campbell D G; Dent P; Gomez N; Lavoinne A; Nakielny S; Stokoe D; Sutherland C; Traverse S
Dissection of the protein kinase cascades involved in insulin and nerve growth factor action.
Biochemical Society transactions 1992;20(3):671-4.
1992: Nakielny S; Cohen P; Wu J; Sturgill T
MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase.
The EMBO journal 1992;11(6):2123-9.
1991: Smythe C; Cohen P
The discovery of glycogenin and the priming mechanism for glycogen biogenesis.
European journal of biochemistry / FEBS 1991;200(3):625-31.
1991: Gómez N; Cohen P
Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases.
Nature 1991;353(6340):170-3.
1991: Cohen P; Hardie D G
The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase.
Biochimica et biophysica acta 1991;1094(3):292-9.
1991: Sola M M; Langan T; Cohen P
p34cdc2 phosphorylation sites in histone H1 are dephosphorylated by protein phosphatase 2A1.
Biochimica et biophysica acta 1991;1094(2):211-6.
1991: Lavoinne A; Erikson E; Maller J L; Price D J; Avruch J; Cohen P
Purification and characterisation of the insulin-stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II.
European journal of biochemistry / FEBS 1991;199(3):723-8.
1991: Nakielny S; Campbell D G; Cohen P
The molecular mechanism by which adrenalin inhibits glycogen synthesis.
European journal of biochemistry / FEBS 1991;199(3):713-22.
1991: James P; Cohen P; Carafoli E
Identification and primary structure of calmodulin binding domains in the phosphorylase kinase holoenzyme.
The Journal of biological chemistry 1991;266(11):7087-91.
1991: MacDougall L K; Jones L R; Cohen P
Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban.
European journal of biochemistry / FEBS 1991;196(3):725-34.
1991: MacKintosh C; Coggins J; Cohen P
Plant protein phosphatases. Subcellular distribution, detection of protein phosphatase 2C and identification of protein phosphatase 2A as the major quinate dehydrogenase phosphatase.
The Biochemical journal 1991;273 ( Pt 3)():733-8.
1990: Dent P; Lavoinne A; Nakielny S; Caudwell F B; Watt P; Cohen P
The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle.
Nature 1990;348(6299):302-8.
1990: Gómez N; Tonks N K; Morrison C; Harmar T; Cohen P
Evidence for communication between nerve growth factor and protein tyrosine phosphorylation.
FEBS letters 1990;271(1-2):119-22.
1990: MacKintosh C; Beattie K A; Klumpp S; Cohen P; Codd G A
Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants.
FEBS letters 1990;264(2):187-92.
1990: Hubbard M J; Dent P; Smythe C; Cohen P
Targetting of protein phosphatase 1 to the sarcoplasmic reticulum of rabbit skeletal muscle by a protein that is very similar or identical to the G subunit that directs the enzyme to glycogen.
European journal of biochemistry / FEBS 1990;189(2):243-9.
1990: Smythe C; Watt P; Cohen P
Further studies on the role of glycogenin in glycogen biosynthesis.
European journal of biochemistry / FEBS 1990;189(1):199-204.
1990: Cohen P; Holmes C F; Tsukitani Y
Okadaic acid: a new probe for the study of cellular regulation.
Trends in biochemical sciences 1990;15(3):98-102.
1990: Dent P; Campbell D G; Caudwell F B; Cohen P
Identification of three in vivo phosphorylation sites on the glycogen-binding subunit of protein phosphatase 1 from rabbit skeletal muscle, and their response to adrenaline.
FEBS letters 1990;259(2):281-5.
1990: Haystead T A; Moore F; Cohen P; Hardie D G
Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes.
European journal of biochemistry / FEBS 1990;187(1):199-205.
1990: Cohen P
The structure and regulation of protein phosphatases.
Advances in second messenger and phosphoprotein research 1990;24():230-5.
1989: Hubbard M J; Cohen P
Regulation of protein phosphatase-1G from rabbit skeletal muscle. 2. Catalytic subunit translocation is a mechanism for reversible inhibition of activity toward glycogen-bound substrates.
European journal of biochemistry / FEBS 1989;186(3):711-6.
1989: Hubbard M J; Cohen P
Regulation of protein phosphatase-1G from rabbit skeletal muscle. 1. Phosphorylation by cAMP-dependent protein kinase at site 2 releases catalytic subunit from the glycogen-bound holoenzyme.
European journal of biochemistry / FEBS 1989;186(3):701-9.
1989: Cohen P; Cohen P T
Protein phosphatases come of age.
The Journal of biological chemistry 1989;264(36):21435-8.
1989: Campbell D G; Cohen P
The amino acid sequence of rabbit skeletal muscle glycogenin.
European journal of biochemistry / FEBS 1989;185(1):119-25.
1989: MacKintosh C; Cohen P
Identification of high levels of type 1 and type 2A protein phosphatases in higher plants.
The Biochemical journal 1989;262(1):335-9.
1989: Cohen P; Schelling D L; Stark M J
Remarkable similarities between yeast and mammalian protein phosphatases.
FEBS letters 1989;250(2):601-6.
1989: Cohen P; Klumpp S; Schelling D L
An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues.
FEBS letters 1989;250(2):596-600.
1989: Smythe C; Villar-Palasi C; Cohen P
Structural and functional studies on rabbit liver glycogenin.
European journal of biochemistry / FEBS 1989;183(1):205-9.
1989: Cohen P T; Cohen P
Discovery of a protein phosphatase activity encoded in the genome of bacteriophage lambda. Probable identity with open reading frame 221.
The Biochemical journal 1989;260(3):931-4.
1989: Cohen P T; Schelling D L; da Cruz e Silva O B; Barker H M; Cohen P
The major type-1 protein phosphatase catalytic subunits are the same gene products in rabbit skeletal muscle and rabbit liver.
Biochimica et biophysica acta 1989;1008(1):125-8.
1989: Dent P; Campbell D G; Hubbard M J; Cohen P
Multisite phosphorylation of the glycogen-binding subunit of protein phosphatase-1G by cyclic AMP-dependent protein kinase and glycogen synthase kinase-3.
FEBS letters 1989;248(1-2):67-72.
1989: Hubbard M J; Cohen P
The glycogen-binding subunit of protein phosphatase-1G from rabbit skeletal muscle. Further characterisation of its structure and glycogen-binding properties.
European journal of biochemistry / FEBS 1989;180(2):457-65.
1989: MacDougall L K; Campbell D G; Hubbard M J; Cohen P
Partial structure and hormonal regulation of rabbit liver inhibitor-1; distribution of inhibitor-1 and inhibitor-2 in rabbit and rat tissues.
Biochimica et biophysica acta 1989;1010(2):218-26.
1989: Haystead T A; Sim A T; Carling D; Honnor R C; Tsukitani Y; Cohen P; Hardie D G
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism.
Nature 1989;337(6202):78-81.
1989: Cohen P
The structure and regulation of protein phosphatases.
Annual review of biochemistry 1989;58():453-508.
1988: Schelling D; Leader D P; Zammit V A; Cohen P
Distinct type-1 protein phosphatases are associated with hepatic glycogen and microsomes.
Biochimica et biophysica acta 1988;972(2):221-31.
1988: Smythe C; Caudwell F B; Ferguson M; Cohen P
Isolation and structural analysis of a peptide containing the novel tyrosyl-glucose linkage in glycogenin.
The EMBO journal 1988;7(9):2681-6.
1988: Pitcher J; Smythe C; Cohen P
Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle.
European journal of biochemistry / FEBS 1988;176(2):391-5.
1988: Chisholm A A; Cohen P
The myosin-bound form of protein phosphatase 1 (PP-1M) is the enzyme that dephosphorylates native myosin in skeletal and cardiac muscles.
Biochimica et biophysica acta 1988;971(2):163-9.
1988: MacKintosh C; Campbell D G; Hiraga A; Cohen P
Phosphorylation of the glycogen-binding subunit of protein phosphatase-1G in response to adrenalin.
FEBS letters 1988;234(1):189-94.
1988: Chisholm A A; Cohen P
Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin.
Biochimica et biophysica acta 1988;968(3):392-400.
1987: Pitcher J; Smythe C; Campbell D G; Cohen P
Identification of the 38-kDa subunit of rabbit skeletal muscle glycogen synthase as glycogenin.
European journal of biochemistry / FEBS 1987;169(3):497-502.
1987: Berndt N; Campbell D G; Caudwell F B; Cohen P; da Cruz e Silva E F; da Cruz e Silva O B; Cohen P T
Isolation and sequence analysis of a cDNA clone encoding a type-1 protein phosphatase catalytic subunit: homology with protein phosphatase 2A.
FEBS letters 1987;223(2):340-6.
1987: Cohen P
Molecular mechanisms involved in the control of glycogenolysis in skeletal muscle by calcium ions and cyclic AMP.
Biochemical Society transactions 1987;15(5):999-1001.

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