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Philip Cohen

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Sam Strickson; David G Campbell; Christoph H Emmerich; Axel Knebel; Lorna Plater; Maria Stella Ritorto; Natalia Shpiro; Philip Cohen
The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system.
Kristopher Clark; J Simon C Arthur; Hwan Geun Choi; Nathanael S Gray; Yosua Kristariyanto; Kirsty F MacKenzie; Ed McIver; Patrick G A Pedrioli; Mark Peggie; Kasparas Petkevicius; Lorna Plater; Jiazhen Zhang; Philip Cohen
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.
Karine Enesa; Alban ORDUREAU; Janet Patterson-Kane; Hilary Smith; J Simon C Arthur; David Barford; Peter C F Cheung; Philip Cohen
Pellino1 is required for interferon production by viral double-stranded RNA.

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All Publications

2013: Sam Strickson; David G Campbell; Christoph H Emmerich; Axel Knebel; Lorna Plater; Maria Stella Ritorto; Natalia Shpiro; Philip Cohen
The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system.
The Biochemical journal 2013;451(3):427-37.
2012: Kristopher Clark; J Simon C Arthur; Hwan Geun Choi; Nathanael S Gray; Yosua Kristariyanto; Kirsty F MacKenzie; Ed McIver; Patrick G A Pedrioli; Mark Peggie; Kasparas Petkevicius; Lorna Plater; Jiazhen Zhang; Philip Cohen
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(42):16986-91.
2012: Karine Enesa; Alban ORDUREAU; Janet Patterson-Kane; Hilary Smith; J Simon C Arthur; David Barford; Peter C F Cheung; Philip Cohen
Pellino1 is required for interferon production by viral double-stranded RNA.
The Journal of biological chemistry 2012;287(41):34825-35.
2012: Eduardo Pauls; Mark Peggie; Natalia Shpiro; Ronald J Sorcek; Li Tan; Erick R Young; Hwan Geun Choi; Philip Cohen
Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells.
The Journal of biological chemistry 2012;287(23):19216-28.
2012: Nicolas Dzamko; Nathanael Gray; Francisco Inesta-Vaquera; Patrick Pedrioli; Li Tan; Chengsong Xie; Jiazhen Zhang; Simon Arthur; Huaibin Cai; Hwanguen Choi; Kristopher Clark; Philip Cohen; Dario R Alessi
The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling.
PloS one 2012;7(6):e39132.
2011: Catherine E Gleason; Robert Gourlay; Alban ORDUREAU; J Simon C Arthur; Philip Cohen
Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.
The Journal of biological chemistry 2011;286(41):35663-74.
2011: Kristopher Clark; Shizuo Akira; Osamu Takeuchi; Philip Cohen
The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(41):17093-8.
2011: Sambit K Nanda; Alban ORDUREAU; Janet C Patterson-Kane; David W Powell; Rachel Toth; Ram K C Venigalla; J Simon C Arthur; Philip Cohen
Polyubiquitin binding to ABIN1 is required to prevent autoimmunity.
The Journal of experimental medicine 2011;208(6):1215-28.
2011: Hilary Smith; Xin-Yu Liu; Liang Dai; Eddy T H Goh; Aye-Thu Chan; Jiajia Xi; Cheah-Chen Seh; Insaf A Qureshi; Julien Lescar; Christiane Ruedl; Robert Gourlay; Simon Morton; Joanne Hough; Edward G McIver; Philip Cohen; Peter C F Cheung
The role of TBK1 and IKKε in the expression and activation of Pellino 1.
The Biochemical journal 2011;434(3):537-48.
2011: Kristopher Clark; Mark Peggie; Lorna Plater; Ronald J Sorcek; Erick R R Young; Jeffrey B Madwed; Joanne Hough; Edward G McIver; Philip Cohen
Novel cross-talk within the IKK family controls innate immunity.
The Biochemical journal 2011;434(1):93-104.
2010: Philip Cohen; Marianna Tcherpakov
Will the ubiquitin system furnish as many drug targets as protein kinases?
Cell 2010;143(5):686-93.
2010: Philip Cohen
Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation.
The Biochemical journal 2010;425(1):53-4.
2009: Hosea Handoyo; Margaret J Stafford; Edward J McManus; Dionissios Baltzis; Mark Peggie; Philip Cohen
IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2.
The Biochemical journal 2009;424(1):109-18.
2009: Kristopher Clark; Lorna Plater; Mark Peggie; Philip Cohen
Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.
The Journal of biological chemistry 2009;284(21):14136-46.
2009: Hilary Smith; Mark Peggie; David G Campbell; Franck VANDERMOERE; Emma Carrick; Philip Cohen
Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(12):4584-90.
2009: Iva V Klevernic; Simon Morton; Roger J Davis; Philip Cohen
Phosphorylation of Ewing's sarcoma protein (EWS) and EWS-Fli1 in response to DNA damage.
The Biochemical journal 2009;418(3):625-34.
2009: Huei-Ting Yang; Mark Peggie; Philip Cohen; Simon Rousseau
DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins.
Biochemical and biophysical research communications 2009;380(3):705-9.
2009: Iva V Klevernic; Niall M B Martin; Philip Cohen
Regulation of the activity and expression of ERK8 by DNA damage.
FEBS letters 2009;583(4):680-4.
2008: Simon Morton; Luke Hesson; Mark Peggie; Philip Cohen
Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma.
FEBS letters 2008;582(6):997-1002.
2008: Mark Windheim; Margaret Stafford; Mark Peggie; Philip Cohen
Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase.
Molecular and cellular biology 2008;28(5):1783-91.
2008: Huei-Ting Yang; Philip Cohen; Simon Rousseau
IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells.
Cellular signalling 2008;20(2):375-80.
2008: Mark Windheim; Mark Peggie; Philip Cohen
Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology.
The Biochemical journal 2008;409(3):723-9.
2008: Heidi Mendoza; David G Campbell; Kerry Burness; James Hastie; Natalia Ronkina; Jae-Hyuck Shim; J Simon C Arthur; Roger J Davis; Matthias Gaestel; Gary L Johnson; Sankar Ghosh; Philip Cohen
Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex.
The Biochemical journal 2008;409(3):711-22.
2008: Simon Rousseau; Matoula Papoutsopoulou; Antony Symons; Dorthe Cook; John M Lucocq; Alan R Prescott; Anne O'Garra; Steven C Ley; Philip Cohen
TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages.
Journal of cell science 2008;121(Pt 2):149-54.
2008: Alban ORDUREAU; Hilary Smith; Mark Windheim; Mark Peggie; Emma Carrick; Nick Morrice; Philip Cohen
The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.
The Biochemical journal 2008;409(1):43-52.
2007: Jenny Bain; Lorna Plater; Matthew Elliott; Natalia Shpiro; C James Hastie; Hilary McLauchlan; Iva Klevernic; J Simon C Arthur; Dario R Alessi; Philip Cohen
The selectivity of protein kinase inhibitors: a further update.
The Biochemical journal 2007;408(3):297-315.
2007: Mark Windheim; Christine Lang; Mark Peggie; Lorna A Plater; Philip Cohen
Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide.
The Biochemical journal 2007;404(2):179-90.
2007: Ana Cuadrado; Vanesa Lafarga; Peter C F Cheung; Ignacio Dolado; Susana Llanos; Philip Cohen; Angel R Nebreda
A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis.
The EMBO journal 2007;26(8):2115-26.
2007: Gopal P Sapkota; Lorna Cummings; Felicity S Newell; Christopher Armstrong; Jenny Bain; Morten Frodin; Matthias Grauert; Matthias Hoffmann; Gisela Schnapp; Martin Steegmaier; Philip Cohen; Dario R Alessi
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo.
The Biochemical journal 2007;401(1):29-38.
2006: Philip Cohen
The twentieth century struggle to decipher insulin signalling.
Nature reviews. Molecular cell biology 2006;7(11):867-73.
2006: Sarah H Conner; Gursant S Kular; Mark Peggie; Sharon Shepherd; Alexander W Schüttelkopf; Philip Cohen; Daan M F van Aalten
TAK1-binding protein 1 is a pseudophosphatase.
The Biochemical journal 2006;399(3):427-34.
2006: Simon Rousseau; Ignacio Dolado; Victoria A Beardmore; Natalia Shpiro; Rodolfo Marquez; Angel R Nebreda; J Simon C Arthur; Lauren M Case; Marc Tessier-Lavigne; Matthias Gaestel; Ana Cuenda; Philip Cohen
CXCL12 and C5a trigger cell migration via a PAK1/2-p38alpha MAPK-MAPKAP-K2-HSP27 pathway.
Cellular signalling 2006;18(11):1897-905.
2006: Simon Morton; Huei-Ting Yang; Ntsane Moleleki; David G Campbell; Philip Cohen; Simon Rousseau
Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ.
The Biochemical journal 2006;399(2):265-73.
2006: Margaret J Stafford; Nick A Morrice; Mark Peggie; Philip Cohen
Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62.
FEBS letters 2006;580(16):4010-4.
2006: Iva V Klevernic; Margaret J Stafford; Nick Morrice; Mark Peggie; Simon Morton; Philip Cohen
Characterization of the reversible phosphorylation and activation of ERK8.
The Biochemical journal 2006;394(Pt 1):365-73.
2006: Philip Cohen; Axel Knebel
KESTREL: a powerful method for identifying the physiological substrates of protein kinases.
The Biochemical journal 2006;393(Pt 1):1-6.
2005: Minghao Zhang; Mark Windheim; S Mark Roe; Mark Peggie; Philip Cohen; Chrisostomos Prodromou; Laurence H Pearl
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.
Molecular cell 2005;20(4):525-38.
2005: Simon Rousseau; Mark Peggie; David G Campbell; Angel R Nebreda; Philip Cohen
Nogo-B is a new physiological substrate for MAPKAP-K2.
The Biochemical journal 2005;391(Pt 2):433-40.
2005: Gillian C Auld; David G Campbell; Nick Morrice; Philip Cohen
Identification of calcium-regulated heat-stable protein of 24 kDa (CRHSP24) as a physiological substrate for PKB and RSK using KESTREL.
The Biochemical journal 2005;389(Pt 3):775-83.
2005: Claire E Eyers; Helen McNeill; Axel Knebel; Nick Morrice; Simon J C Arthur; Ana Cuenda; Philip Cohen
The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ.
The Biochemical journal 2005;389(Pt 1):127-35.
2005: Robert A Cartlidge; Axel Knebel; Mark Peggie; Andrei Alexandrov; Eric M Phizicky; Philip Cohen
The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.
The EMBO journal 2005;24(9):1696-705.
2005: James T Murray; Lorna A Cummings; Graham B Bloomberg; Philip Cohen
Identification of different specificity requirements between SGK1 and PKBalpha.
FEBS letters 2005;579(5):991-4.
2004: James T Murray; David G Campbell; Nick Morrice; Gillian C Auld; Natalia Shpiro; Rodolfo Marquez; Mark Peggie; Jenny Bain; Graham B Bloomberg; Florian Grahammer; Florian Lang; Peer Wulff; Dietmar Kuhl; Philip Cohen
Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3.
The Biochemical journal 2004;384(Pt 3):477-88.
2004: James T Murray; David G Campbell; Mark Peggie; Alfonso Mora; Mora Alfonso; Philip Cohen
Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL.
The Biochemical journal 2004;384(Pt 3):489-94.
2004: Helen McNeill; Axel Knebel; J Simon C Arthur; Ana Cuenda; Philip Cohen
A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs.
The Biochemical journal 2004;384(Pt 2):391-400.
2004: Simon Morton; Roger J Davis; Philip Cohen
Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2.
FEBS letters 2004;572(1-3):177-83.
2004: Philip Cohen
Philip Cohen.
Current biology : CB 2004;14(15):R597-8.
2004: Hirotaka Yoshida; C James Hastie; Hilary McLauchlan; Philip Cohen; Michel Goedert
Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK).
Journal of neurochemistry 2004;90(2):352-8.
2004: Philip Cohen; Michel Goedert
GSK3 inhibitors: development and therapeutic potential.
Nature reviews. Drug discovery 2004;3(6):479-87.
2004: Peter C F Cheung; Angel R Nebreda; Philip Cohen
TAB3, a new binding partner of the protein kinase TAK1.
The Biochemical journal 2004;378(Pt 1):27-34.
2004: Graham Rena; Jenny Bain; Matthew Elliott; Philip Cohen
D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.
EMBO reports 2004;5(1):60-5.
2004: Adam Cole; Sheelagh Frame; Philip Cohen
Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event.
The Biochemical journal 2004;377(Pt 1):249-55.
2003: Peter C F Cheung; David G Campbell; Angel R Nebreda; Philip Cohen
Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha.
The EMBO journal 2003;22(21):5793-805.
2003: Simon Morton; Roger J Davis; Ann McLaren; Philip Cohen
A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun.
The EMBO journal 2003;22(15):3876-86.
2003: Nimesh Mody; David G Campbell; Nick Morrice; Mark Peggie; Philip Cohen
An analysis of the phosphorylation and activation of extracellular-signal-regulated protein kinase 5 (ERK5) by mitogen-activated protein kinase kinase 5 (MKK5) in vitro.
The Biochemical journal 2003;372(Pt 2):567-75.
2003: Jenny Bain; Hilary McLauchlan; Matthew Elliott; Philip Cohen
The specificities of protein kinase inhibitors: an update.
The Biochemical journal 2003;371(Pt 1):199-204.
2002: Simon Rousseau; Nick Morrice; Mark Peggie; David G Campbell; Matthias Gaestel; Philip Cohen
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.
The EMBO journal 2002;21(23):6505-14.
2002: Axel Knebel; Claire E Haydon; Nick Morrice; Philip Cohen
Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.
The Biochemical journal 2002;367(Pt 2):525-32.
2002: Heike Ross; Christopher G Armstrong; Philip Cohen
A non-radioactive method for the assay of many serine/threonine-specific protein kinases.
The Biochemical journal 2002;366(Pt 3):977-81.
2002: Guillermo Velasco; Chris Armstrong; Nick Morrice; Sheelagh Frame; Philip Cohen
Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin.
FEBS letters 2002;527(1-3):101-4.
2002: Philip Cohen
The origins of protein phosphorylation.
Nature cell biology 2002;4(5):E127-30.
2002: Graham Rena; Yvonne L Woods; Alan R Prescott; Mark Peggie; Terry G Unterman; Michayla R Williams; Philip Cohen
Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion.
The EMBO journal 2002;21(9):2263-71.
2002: Philip Cohen
Protein kinases--the major drug targets of the twenty-first century?
Nature reviews. Drug discovery 2002;1(4):309-15.
2002: Giselle R Wiggin; Ana Soloaga; Julia M Foster; Victoria Murray-Tait; Philip Cohen; J Simon C Arthur
MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts.
Molecular and cellular biology 2002;22(8):2871-81.
2002: Linda Trotter; Wendy Panton; Iradj Hajimohamadreza; Lawrence Petalidis; Robin Ward; Yvonne Fleming; Christopher G Armstrong; Philip Cohen; Eric H Karran; Ross A Kinloch
Mitogen-activated protein kinase kinase 7 is activated during low potassium-induced apoptosis in rat cerebellar granule neurons.
Neuroscience letters 2002;320(1-2):29-32.
2002: Susanna C Fagerholm; Nick Morrice; Carl G Gahmberg; Philip Cohen
Phosphorylation of the cytoplasmic domain of the integrin CD18 chain by protein kinase C isoforms in leukocytes.
The Journal of biological chemistry 2002;277(3):1728-38.
2002: Claire E Haydon; Peter W Watt; Nick Morrice; Axel Knebel; Matthias Gaestel; Philip Cohen
Identification of a phosphorylation site on skeletal muscle myosin light chain kinase that becomes phosphorylated during muscle contraction.
Archives of biochemistry and biophysics 2002;397(2):224-31.
2001: M Caivano; Barbara Gorgoni; Philip Cohen; Valeria Poli
The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta ) and C/EBP delta transcription factors.
The Journal of biological chemistry 2001;276(52):48693-701.
2001: Philip Cohen
The role of protein phosphorylation in human health and disease. The Sir Hans Krebs Medal Lecture.
European journal of biochemistry / FEBS 2001;268(19):5001-10.
2001: Philip Cohen; Sheelagh Frame
The renaissance of GSK3.
Nature reviews. Molecular cell biology 2001;2(10):769-76.
2001: Sheelagh Frame; Philip Cohen
GSK3 takes centre stage more than 20 years after its discovery.
The Biochemical journal 2001;359(Pt 1):1-16.
2001: Axel Knebel; Nick Morrice; Philip Cohen
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta.
The EMBO journal 2001;20(16):4360-9.
2001: N Mody; J Leitch; C Armstrong; J Dixon; Philip Cohen
Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway.
FEBS letters 2001;502(1-2):21-4.
2001: Sheelagh Frame; Philip Cohen; Ricardo M Biondi
A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation.
Molecular cell 2001;7(6):1321-7.
2001: Yvonne L Woods; Philip Cohen; Walter Becker; Ross Jakes; Michel Goedert; Xuemin Wang; Christopher G Proud
The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.
The Biochemical journal 2001;355(Pt 3):609-15.
2001: Yvonne L Woods; Graham Rena; Nick Morrice; Andreas Barthel; Walter Becker; S Guo; Terry G Unterman; Philip Cohen
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.
The Biochemical journal 2001;355(Pt 3):597-607.
2001: Peter C F Cheung; Laura Trinkle-Mulcahy; Philip Cohen; John M Lucocq
Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi.
The Biochemical journal 2001;355(Pt 1):113-21.
2001: Graham Rena; Alan R Prescott; S Guo; Philip Cohen; Terry G Unterman
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.
The Biochemical journal 2001;354(Pt 3):605-12.
2001: Susanna C Fagerholm; A Prescott; Philip Cohen; Carl G Gahmberg
An essential role for calmodulin in regulating human T cell aggregation.
FEBS letters 2001;491(1-2):131-6.
2000: Y Hefner; A G Borsch-Haubold; M Murakami; Jonathan Wilde; S Pasquet; DM Schieltz; Farideh Ghomashchi; John R Yates; Christopher G Armstrong; A Paterson; Philip Cohen; R Fukunaga; Tony Hunter; I Kudo; Steve P Watson; Michael H Gelb
Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.
The Journal of biological chemistry 2000;275(48):37542-51.
2000: Yvonne Fleming; Christopher G Armstrong; Nick Morrice; A Paterson; Michel Goedert; Philip Cohen
Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7.
The Biochemical journal 2000;352 Pt 1():145-54.
2000: SP Davies; H Reddy; M Caivano; Philip Cohen
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
The Biochemical journal 2000;351(Pt 1):95-105.
2000: J Simon C Arthur; Philip Cohen
MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells.
FEBS letters 2000;482(1-2):44-8.
2000: Jose Lizcano; Nick Morrice; Philip Cohen
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
The Biochemical journal 2000;349(Pt 2):547-57.
2000: Michayla R Williams; J Simon C Arthur; A Balendran; Jeroen van der Kaay; V Poli; Philip Cohen; Dario R Alessi
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells.
Current biology : CB 2000;10(8):439-48.
2000: M Caivano; Philip Cohen
Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(6):3018-25.
2000: KS Walker; Peter W Watt; Philip Cohen
Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivo.
FEBS letters 2000;466(1):121-4.
1999: A C Chang; Björn Sohlberg; Laura Trinkle-Mulcahy; F Claverie-Martin; Philip Cohen; Stanley N Cohen
Alternative splicing regulates the production of ARD-1 endoribonuclease and NIPP-1, an inhibitor of protein phosphatase-1, as isoforms encoded by the same gene.
Gene 1999;240(1):45-55.
1999: T Kobayashi; Maria Deak; Nick Morrice; Philip Cohen
Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.
The Biochemical journal 1999;344 Pt 1():189-97.
1999: M Shaw; Philip Cohen
Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells.
FEBS letters 1999;461(1-2):120-4.
1999: AG Börsch-Haubold; Farideh Ghomashchi; S Pasquet; Michel Goedert; Philip Cohen; M H Gelb; Steve P Watson
Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways.
European journal of biochemistry / FEBS 1999;265(1):195-203.
1999: Gareth M Thomas; Sheelagh Frame; Michel Goedert; I Nathke; P Polakis; Philip Cohen
A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin.
FEBS letters 1999;458(2):247-51.
1999: CA Hall-Jackson; PA Eyers; Philip Cohen; Michel Goedert; F T Boyle; N Hewitt; H Plant; P Hedge
Paradoxical activation of Raf by a novel Raf inhibitor.
Chemistry & biology 1999;6(8):559-68.
1999: Graham Rena; S Guo; S C Cichy; Terry G Unterman; Philip Cohen
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B.
The Journal of biological chemistry 1999;274(24):17179-83.
1999: PA Eyers; Paul van den IJssel; Roy A Quinlan; Michel Goedert; Philip Cohen
Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580.
FEBS letters 1999;451(2):191-6.
1999: M Hasegawa; Ana Cuenda; Maria Grazia Spillantini; Gareth M Thomas; Valérie Buée-Scherrer; Philip Cohen; Michel Goedert
Stress-activated protein kinase-3 interacts with the PDZ domain of alpha1-syntrophin. A mechanism for specific substrate recognition.
The Journal of biological chemistry 1999;274(18):12626-31.
1999: T Kobayashi; Philip Cohen
Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.
The Biochemical journal 1999;339 ( Pt 2)():319-28.
1999: CA Hall-Jackson; Michel Goedert; P Hedge; Philip Cohen
Effect of SB 203580 on the activity of c-Raf in vitro and in vivo.
Oncogene 1999;18(12):2047-54.
1999: Philip Cohen
The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1382):485-95.
1999: Ana Cuenda; Philip Cohen
Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis.
The Journal of biological chemistry 1999;274(7):4341-6.
1999: RA Currie; KS Walker; Alex Gray; Maria Deak; Antonio Casamayor; C Peter Downes; Philip Cohen; Dario R Alessi; John M Lucocq
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1.
The Biochemical journal 1999;337 ( Pt 3)():575-83.
1999: Laura Trinkle-Mulcahy; Paul Ajuh; Alan R Prescott; F Claverie-Martin; S Cohen; Angus I Lamond; Philip Cohen
Nuclear organisation of NIPP1, a regulatory subunit of protein phosphatase 1 that associates with pre-mRNA splicing factors.
Journal of cell science 1999;112 ( Pt 2)():157-68.
1998: S Lawler; Yvonne Fleming; Michel Goedert; Philip Cohen
Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro.
Current biology : CB 1998;8(25):1387-90.
1998: M Shaw; Philip Cohen; Dario R Alessi
The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2.
The Biochemical journal 1998;336 ( Pt 1)():241-6.
1998: Greg B G Moorhead; D Johnson; Nick Morrice; Philip Cohen
The major myosin phosphatase in skeletal muscle is a complex between the beta-isoform of protein phosphatase 1 and the MYPT2 gene product.
FEBS letters 1998;438(3):141-4.
1998: Y N Doza; CA Hall-Jackson; Philip Cohen
Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos.
Oncogene 1998;17(1):19-24.
1998: Philip Cohen; Michel Goedert
Engineering protein kinases with distinct nucleotide specificities and inhibitor sensitivities by mutation of a single amino acid.
Chemistry & biology 1998;5(7):R161-4.
1998: PA Eyers; M Craxton; Nick Morrice; Philip Cohen; Michel Goedert
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution.
Chemistry & biology 1998;5(6):321-8.
1998: KS Walker; Maria Deak; A Paterson; K Hudson; Philip Cohen; Dario R Alessi
Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha.
The Biochemical journal 1998;331 ( Pt 1)():299-308.
1998: Philip Cohen
The Department of Biochemistry at the University of Dundee.
Molecular medicine (Cambridge, Mass.) 1998;4(2):65-9.
1998: Dario R Alessi; Philip Cohen
Mechanism of activation and function of protein kinase B.
Current opinion in genetics & development 1998;8(1):55-62.
1998: K N Dalby; Nick Morrice; F B Caudwell; Joseph Avruch; Philip Cohen
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK.
The Journal of biological chemistry 1998;273(3):1496-505.
1997: Christopher G Armstrong; Gareth J Browne; Philip Cohen; Patricia T W Cohen
PPP1R6, a novel member of the family of glycogen-targetting subunits of protein phosphatase 1.
FEBS letters 1997;418(1-2):210-4.
1997: Gareth M Thomas; J Haavik; Philip Cohen
A stress-activated kinase cascade can mediate the activation of tyrosine hydroxylase in chromaffin cells.
Biochemical Society transactions 1997;25(4):S571.
1997: Ana Cuenda; Michel Goedert; Molly Craxton; Ross Jakes; Philip Cohen
Activation of the novel MAP kinase homologue SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6).
Biochemical Society transactions 1997;25(4):S569.
1997: M Shaw; Philip Cohen; Dario R Alessi
Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216.
FEBS letters 1997;416(3):307-11.
1997: S Lawler; Ana Cuenda; Michel Goedert; Philip Cohen
SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK).
FEBS letters 1997;414(1):153-8.
1997: Gareth M Thomas; J Haavik; Philip Cohen
Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells.
European journal of biochemistry / FEBS 1997;247(3):1180-9.
1997: Philip Cohen; Dario R Alessi; Darren A E Cross
PDK1, one of the missing links in insulin signal transduction?
FEBS letters 1997;410(1):3-10.
1997: Michel Goedert; Ana Cuenda; Molly Craxton; Ross Jakes; Philip Cohen
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.
The EMBO journal 1997;16(12):3563-71.
1997: Michel Goedert; M Hasegawa; Ross Jakes; S Lawler; Ana Cuenda; Philip Cohen
Phosphorylation of microtubule-associated protein tau by stress-activated protein kinases.
FEBS letters 1997;409(1):57-62.
1997: M P Egloff; D F Johnson; G Moorhead; Patricia T W Cohen; Philip Cohen; David Barford
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1.
The EMBO journal 1997;16(8):1876-87.
1997: Darren A E Cross; Peter W Watt; M Shaw; Jeroen van der Kaay; C Peter Downes; Julie C Holder; Philip Cohen
Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue.
FEBS letters 1997;406(1-2):211-5.
1997: Dario R Alessi; SR James; C Peter Downes; Andrew B Holmes; PR Gaffney; CB Reese; Philip Cohen
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha.
Current biology : CB 1997;7(4):261-9.
1997: D Johnson; Philip Cohen; M X Chen; Y H Chen; Patricia T W Cohen
Identification of the regions on the M110 subunit of protein phosphatase 1M that interact with the M21 subunit and with myosin.
European journal of biochemistry / FEBS 1997;244(3):931-9.
1997: Ana Cuenda; Philip Cohen; Valérie Buée-Scherrer; Michel Goedert
Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38).
The EMBO journal 1997;16(2):295-305.
1996: Dario R Alessi; F B Caudwell; Mirjana Andjelkovic; Brian A Hemmings; Philip Cohen
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase.
FEBS letters 1996;399(3):333-8.
1996: Dario R Alessi; Mirjana Andjelkovic; B Caudwell; P Cron; Nick Morrice; Philip Cohen; Brian A Hemmings
Mechanism of activation of protein kinase B by insulin and IGF-1.
The EMBO journal 1996;15(23):6541-51.
1996: Carol MacKintosh; A J Garton; A McDonnell; D Barford; Patricia T W Cohen; N K Tonks; Philip Cohen
Further evidence that inhibitor-2 acts like a chaperone to fold PP1 into its native conformation.
FEBS letters 1996;397(2-3):235-8.
1996: A D Clifton; Peter Young; Philip Cohen
A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress.
FEBS letters 1996;392(3):209-14.
1996: Ana Cuenda; G Alonso; Nick Morrice; M Jones; R Meier; Philip Cohen; A R Nebreda
Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells.
The EMBO journal 1996;15(16):4156-64.
1996: D F Johnson; Greg B G Moorhead; F B Caudwell; Philip Cohen; Y H Chen; M X Chen; Patricia T W Cohen
Identification of protein-phosphatase-1-binding domains on the glycogen and myofibrillar targetting subunits.
European journal of biochemistry / FEBS 1996;239(2):317-25.
1996: R D Gordon; I A Leighton; D G Campbell; Philip Cohen; A Creaney; D C Wilton; D J Masters; G A Ritchie; R Mott; I W Taylor; K R Bundell; L Douglas; J Morten; M Needham
Cloning and expression of cystolic phospholipase A2 (cPLA2) and a naturally occurring variant. Phosphorylation of Ser505 of recombinant cPLA2 by p42 mitogen-activated protein kinase results in an increase in specific activity.
European journal of biochemistry / FEBS 1996;238(3):690-7.
1996: R Meier; J Rouse; Ana Cuenda; A R Nebreda; Philip Cohen
Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells.
European journal of biochemistry / FEBS 1996;236(3):796-805.
1996: Philip Cohen
Dissection of protein kinase cascades that mediate cellular response to cytokines and cellular stress.
Advances in pharmacology (San Diego, Calif.) 1996;36():15-27.
1995: Darren A E Cross; Dario R Alessi; Philip Cohen; M Andjelkovich; Brian A Hemmings
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
Nature 1995;378(6559):785-9.
1995: M J Doherty; Greg B G Moorhead; Nick Morrice; Philip Cohen; Patricia T W Cohen
Amino acid sequence and expression of the hepatic glycogen-binding (GL)-subunit of protein phosphatase-1.
FEBS letters 1995;375(3):294-8.
1995: I A Leighton; K N Dalby; F B Caudwell; Patricia T W Cohen; Philip Cohen
Comparison of the specificities of p70 S6 kinase and MAPKAP kinase-1 identifies a relatively specific substrate for p70 S6 kinase: the N-terminal kinase domain of MAPKAP kinase-1 is essential for peptide phosphorylation.
FEBS letters 1995;375(3):289-93.
1995: Dario R Alessi; A Cuenda; Philip Cohen; D T Dudley; Alan Saltiel
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.
The Journal of biological chemistry 1995;270(46):27489-94.
1995: R M Baxter; Philip Cohen; A Obermeier; A Ullrich; C Peter Downes; Y N Doza
Phosphotyrosine residues in the nerve-growth-factor receptor (Trk-A). Their role in the activation of inositolphospholipid metabolism and protein kinase cascades in phaeochromocytoma (PC12) cells.
European journal of biochemistry / FEBS 1995;234(1):84-91.
1995: R W MacKintosh; K N Dalby; D G Campbell; Patricia T W Cohen; Philip Cohen; Carol MacKintosh
The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1.
FEBS letters 1995;371(3):236-40.
1995: Ana Cuenda; J Rouse; Y N Doza; R Meier; Philip Cohen; T F Gallagher; Peter Young; J C Lee
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.
FEBS letters 1995;364(2):229-33.
1995: Y N Doza; Ana Cuenda; Gareth M Thomas; Philip Cohen; A R Nebreda
Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.
FEBS letters 1995;364(2):223-8.
1995: Michel Goedert; Maria Grazia Spillantini; Ross Jakes; R Anthony Crowther; Eugeen Vanmechelen; A Probst; J Götz; K Bürki; Philip Cohen
Molecular dissection of the paired helical filament.
Neurobiology of aging 1995;16(3):325-34.
1995: Greg B G Moorhead; Carol MacKintosh; Nick Morrice; Philip Cohen
Purification of the hepatic glycogen-associated form of protein phosphatase-1 by microcystin-Sepharose affinity chromatography.
FEBS letters 1995;362(2):101-5.
1995: Dario R Alessi; N Gomez; Greg B G Moorhead; T Lewis; Stephen M Keyse; Philip Cohen
Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines.
Current biology : CB 1995;5(3):283-95.
1995: Michel Goedert; Ross Jakes; Maria Grazia Spillantini; R Anthony Crowther; Philip Cohen; Eugeen Vanmechelen; A Probst; J Götz; K Bürki
Tau protein in Alzheimer's disease.
Biochemical Society transactions 1995;23(1):80-5.
1995: Dario R Alessi; Philip Cohen; Alan Ashworth; S Cowley; S J Leevers; C J Marshall
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf.
Methods in enzymology 1995;255():279-90.
1994: Y H Chen; M X Chen; Dario R Alessi; D G Campbell; C Shanahan; Philip Cohen; Patricia T W Cohen
Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M.
FEBS letters 1994;356(1):51-5.
1994: Y Saito; J R Vandenheede; Philip Cohen
The mechanism by which epidermal growth factor inhibits glycogen synthase kinase 3 in A431 cells.
The Biochemical journal 1994;303 ( Pt 1)():27-31.
1994: Darren A E Cross; Dario R Alessi; J R Vandenheede; H E McDowell; Harinder S Hundal; Philip Cohen
The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf.
The Biochemical journal 1994;303 ( Pt 1)():21-6.
1994: J Rouse; Philip Cohen; S Trigon; Michel Morange; A Alonso-Llamazares; D Zamanillo; Tim Hunt; A R Nebreda
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins.
Cell 1994;78(6):1027-37.
1994: S Traverse; Philip Cohen
Identification of a latent MAP kinase kinase kinase in PC12 cells as B-raf.
FEBS letters 1994;350(1):13-8.
1994: S Traverse; K Seedorf; H Paterson; C J Marshall; Philip Cohen; A Ullrich
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor.
Current biology : CB 1994;4(8):694-701.
1994: Michel Goedert; Ross Jakes; R Anthony Crowther; Philip Cohen; Eugeen Vanmechelen; M Vandermeeren; Patrick Cras
Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein.
The Biochemical journal 1994;301 ( Pt 3)():871-7.
1994: Dario R Alessi; Y Saito; D G Campbell; Philip Cohen; G Sithanandam; U Rapp; Alan Ashworth; C J Marshall; S Cowley
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
The EMBO journal 1994;13(7):1610-9.
1994: Y Saito; N Gomez; D G Campbell; Alan Ashworth; C J Marshall; Philip Cohen
The threonine residues in MAP kinase kinase 1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor-stimulated rat phaeochromocytoma (PC12) cells.
FEBS letters 1994;341(1):119-24.
1994: Calum Sutherland; Philip Cohen
The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro.
FEBS letters 1994;338(1):37-42.
1993: Paul Clarke; S R Siddhanti; Philip Cohen; Perry Blackshear
Okadaic acid-sensitive protein phosphatases dephosphorylate MARCKS, a major protein kinase C substrate.
FEBS letters 1993;336(1):37-42.
1993: David Stokoe; B Caudwell; Patricia T W Cohen; Philip Cohen
The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.
The Biochemical journal 1993;296 ( Pt 3)():843-9.
1993: Calum Sutherland; I A Leighton; Philip Cohen
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.
The Biochemical journal 1993;296 ( Pt 1)():15-9.
1993: S Traverse; Philip Cohen; H Paterson; C Marshall; U Rapp; R J Grand
Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.
Oncogene 1993;8(11):3175-81.
1993: I A Leighton; P Curmi; D G Campbell; Philip Cohen; A Sobel
The phosphorylation of stathmin by MAP kinase.
Molecular and cellular biochemistry 1993;127-128():151-6.
1993: Calum Sutherland; J Alterio; D G Campbell; B Le Bourdellès; Jacques Mallet; J Haavik; Philip Cohen
Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2.
European journal of biochemistry / FEBS 1993;217(2):715-22.
1993: Philip Cohen
Dissection of the protein phosphorylation cascades involved in insulin and growth factor action.
Biochemical Society transactions 1993;21 ( Pt 3)(3):555-67.
1993: P Ferrigno; T A Langan; Philip Cohen
Protein phosphatase 2A1 is the major enzyme in vertebrate cell extracts that dephosphorylates several physiological substrates for cyclin-dependent protein kinases.
Molecular biology of the cell 1993;4(7):669-77.
1993: Dario R Alessi; A J Street; Philip Cohen; Patricia T W Cohen
Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme.
European journal of biochemistry / FEBS 1993;213(3):1055-66.
1993: C Sutherland; D G Campbell; Philip Cohen
Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase.
European journal of biochemistry / FEBS 1993;212(2):581-8.
1992: N Gomez; S Traverse; Philip Cohen
Identification of a MAP kinase kinase kinase in phaeochromocytoma (PC12) cells.
FEBS letters 1992;314(3):461-5.
1992: P Dent; L K MacDougall; Carol MacKintosh; D G Campbell; Philip Cohen
A myofibrillar protein phosphatase from rabbit skeletal muscle contains the beta isoform of protein phosphatase-1 complexed to a regulatory subunit which greatly enhances the dephosphorylation of myosin.
European journal of biochemistry / FEBS 1992;210(3):1037-44.
1992: Dario R Alessi; L K MacDougall; M M Sola; M Ikebe; Philip Cohen
The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1.
European journal of biochemistry / FEBS 1992;210(3):1023-35.
1992: Alan Ashworth; S Nakielny; Philip Cohen; C Marshall
The amino acid sequence of a mammalian MAP kinase kinase.
Oncogene 1992;7(12):2555-6.
1992: S Traverse; N Gomez; H Paterson; C Marshall; Philip Cohen
Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor.
The Biochemical journal 1992;288 ( Pt 2)():351-5.
1992: David Stokoe; K Engel; D G Campbell; Philip Cohen; M Gaestel
Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins.
FEBS letters 1992;313(3):307-13.
1992: Michel Goedert; E S Cohen; Ross Jakes; Philip Cohen
p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. Implications for Alzheimer's disease [corrected].
FEBS letters 1992;312(1):95-9.
1992: David Stokoe; D G Campbell; S Nakielny; H Hidaka; S J Leevers; C Marshall; Philip Cohen
MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.
The EMBO journal 1992;11(11):3985-94.
1992: L R Howe; S J Leevers; N Gómez; S Nakielny; Philip Cohen; C J Marshall
Activation of the MAP kinase pathway by the protein kinase raf.
Cell 1992;71(2):335-42.
1992: Philip Cohen
Signal integration at the level of protein kinases, protein phosphatases and their substrates.
Trends in biochemical sciences 1992;17(10):408-13.
1992: S Nakielny; D G Campbell; Philip Cohen
MAP kinase kinase from rabbit skeletal muscle. A novel dual specificity enzyme showing homology to yeast protein kinases involved in pheromone-dependent signal transduction.
FEBS letters 1992;308(2):183-9.
1992: Philip Cohen; D G Campbell; P Dent; N Gomez; A Lavoinne; S Nakielny; David Stokoe; Calum Sutherland; S Traverse
Dissection of the protein kinase cascades involved in insulin and nerve growth factor action.
Biochemical Society transactions 1992;20(3):671-4.
1992: S Nakielny; Philip Cohen; Jie Wu; T Sturgill
MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase.
The EMBO journal 1992;11(6):2123-9.
1991: Philip Cohen; D Grahame Hardie
The actions of cyclic AMP on biosynthetic processes are mediated indirectly by cyclic AMP-dependent protein kinase.
Biochimica et biophysica acta 1991;1094(3):292-9.
1991: Carl Smythe; Philip Cohen
The discovery of glycogenin and the priming mechanism for glycogen biogenesis.
European journal of biochemistry / FEBS 1991;200(3):625-31.
1991: N Gómez; Philip Cohen
Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases.
Nature 1991;353(6340):170-3.
1991: M M Sola; T Langan; Philip Cohen
p34cdc2 phosphorylation sites in histone H1 are dephosphorylated by protein phosphatase 2A1.
Biochimica et biophysica acta 1991;1094(2):211-6.
1991: A Lavoinne; E Erikson; J L Maller; D J Price; Joseph Avruch; Philip Cohen
Purification and characterisation of the insulin-stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II.
European journal of biochemistry / FEBS 1991;199(3):723-8.
1991: S Nakielny; D G Campbell; Philip Cohen
The molecular mechanism by which adrenalin inhibits glycogen synthesis.
European journal of biochemistry / FEBS 1991;199(3):713-22.
1991: P James; Philip Cohen; E Carafoli
Identification and primary structure of calmodulin binding domains in the phosphorylase kinase holoenzyme.
The Journal of biological chemistry 1991;266(11):7087-91.
1991: L K MacDougall; L R Jones; Philip Cohen
Identification of the major protein phosphatases in mammalian cardiac muscle which dephosphorylate phospholamban.
European journal of biochemistry / FEBS 1991;196(3):725-34.
1991: Carol MacKintosh; J Coggins; Philip Cohen
Plant protein phosphatases. Subcellular distribution, detection of protein phosphatase 2C and identification of protein phosphatase 2A as the major quinate dehydrogenase phosphatase.
The Biochemical journal 1991;273 ( Pt 3)():733-8.
1990: P Dent; A Lavoinne; S Nakielny; F B Caudwell; P Watt; Philip Cohen
The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle.
Nature 1990;348(6299):302-8.
1990: N Gómez; N K Tonks; C Morrison; T Harmar; Philip Cohen
Evidence for communication between nerve growth factor and protein tyrosine phosphorylation.
FEBS letters 1990;271(1-2):119-22.
1990: Carol MacKintosh; Kenneth A Beattie; S Klumpp; Philip Cohen; Geoffrey A Codd
Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants.
FEBS letters 1990;264(2):187-92.
1990: M J Hubbard; P Dent; Carl Smythe; Philip Cohen
Targetting of protein phosphatase 1 to the sarcoplasmic reticulum of rabbit skeletal muscle by a protein that is very similar or identical to the G subunit that directs the enzyme to glycogen.
European journal of biochemistry / FEBS 1990;189(2):243-9.
1990: Carl Smythe; P Watt; Philip Cohen
Further studies on the role of glycogenin in glycogen biosynthesis.
European journal of biochemistry / FEBS 1990;189(1):199-204.
1990: Philip Cohen; C F Holmes; Y Tsukitani
Okadaic acid: a new probe for the study of cellular regulation.
Trends in biochemical sciences 1990;15(3):98-102.
1990: T A Haystead; F Moore; Philip Cohen; D Grahame Hardie
Roles of the AMP-activated and cyclic-AMP-dependent protein kinases in the adrenaline-induced inactivation of acetyl-CoA carboxylase in rat adipocytes.
European journal of biochemistry / FEBS 1990;187(1):199-205.
1990: Philip Cohen
The structure and regulation of protein phosphatases.
Advances in second messenger and phosphoprotein research 1990;24():230-5.
1990: P Dent; D G Campbell; F B Caudwell; Philip Cohen
Identification of three in vivo phosphorylation sites on the glycogen-binding subunit of protein phosphatase 1 from rabbit skeletal muscle, and their response to adrenaline.
FEBS letters 1990;259(2):281-5.
1989: Philip Cohen; P T Cohen
Protein phosphatases come of age.
The Journal of biological chemistry 1989;264(36):21435-8.
1989: M J Hubbard; Philip Cohen
Regulation of protein phosphatase-1G from rabbit skeletal muscle. 2. Catalytic subunit translocation is a mechanism for reversible inhibition of activity toward glycogen-bound substrates.
European journal of biochemistry / FEBS 1989;186(3):711-6.
1989: M J Hubbard; Philip Cohen
Regulation of protein phosphatase-1G from rabbit skeletal muscle. 1. Phosphorylation by cAMP-dependent protein kinase at site 2 releases catalytic subunit from the glycogen-bound holoenzyme.
European journal of biochemistry / FEBS 1989;186(3):701-9.
1989: D G Campbell; Philip Cohen
The amino acid sequence of rabbit skeletal muscle glycogenin.
European journal of biochemistry / FEBS 1989;185(1):119-25.
1989: Carol MacKintosh; Philip Cohen
Identification of high levels of type 1 and type 2A protein phosphatases in higher plants.
The Biochemical journal 1989;262(1):335-9.
1989: Carl Smythe; C Villar-Palasi; Philip Cohen
Structural and functional studies on rabbit liver glycogenin.
European journal of biochemistry / FEBS 1989;183(1):205-9.
1989: Philip Cohen; D L Schelling; M J Stark
Remarkable similarities between yeast and mammalian protein phosphatases.
FEBS letters 1989;250(2):601-6.
1989: Philip Cohen; S Klumpp; D L Schelling
An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues.
FEBS letters 1989;250(2):596-600.
1989: Patricia T W Cohen; Philip Cohen
Discovery of a protein phosphatase activity encoded in the genome of bacteriophage lambda. Probable identity with open reading frame 221.
The Biochemical journal 1989;260(3):931-4.
1989: Patricia T W Cohen; D L Schelling; O B da Cruz e Silva; H M Barker; Philip Cohen
The major type-1 protein phosphatase catalytic subunits are the same gene products in rabbit skeletal muscle and rabbit liver.
Biochimica et biophysica acta 1989;1008(1):125-8.
1989: P Dent; D G Campbell; M J Hubbard; Philip Cohen
Multisite phosphorylation of the glycogen-binding subunit of protein phosphatase-1G by cyclic AMP-dependent protein kinase and glycogen synthase kinase-3.
FEBS letters 1989;248(1-2):67-72.
1989: M J Hubbard; Philip Cohen
The glycogen-binding subunit of protein phosphatase-1G from rabbit skeletal muscle. Further characterisation of its structure and glycogen-binding properties.
European journal of biochemistry / FEBS 1989;180(2):457-65.
1989: L K MacDougall; D G Campbell; M J Hubbard; Philip Cohen
Partial structure and hormonal regulation of rabbit liver inhibitor-1; distribution of inhibitor-1 and inhibitor-2 in rabbit and rat tissues.
Biochimica et biophysica acta 1989;1010(2):218-26.
1989: T A Haystead; A T Sim; David Carling; R C Honnor; Y Tsukitani; Philip Cohen; D Grahame Hardie
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism.
Nature 1989;337(6202):78-81.
1989: Philip Cohen
The structure and regulation of protein phosphatases.
Annual review of biochemistry 1989;58():453-508.
1988: D Schelling; D P Leader; V A Zammit; Philip Cohen
Distinct type-1 protein phosphatases are associated with hepatic glycogen and microsomes.
Biochimica et biophysica acta 1988;972(2):221-31.
1988: A A Chisholm; Philip Cohen
The myosin-bound form of protein phosphatase 1 (PP-1M) is the enzyme that dephosphorylates native myosin in skeletal and cardiac muscles.
Biochimica et biophysica acta 1988;971(2):163-9.
1988: J Pitcher; Carl Smythe; Philip Cohen
Glycogenin is the priming glucosyltransferase required for the initiation of glycogen biogenesis in rabbit skeletal muscle.
European journal of biochemistry / FEBS 1988;176(2):391-5.
1988: Carl Smythe; F B Caudwell; M Ferguson; Philip Cohen
Isolation and structural analysis of a peptide containing the novel tyrosyl-glucose linkage in glycogenin.
The EMBO journal 1988;7(9):2681-6.
1988: Carol MacKintosh; D G Campbell; A Hiraga; Philip Cohen
Phosphorylation of the glycogen-binding subunit of protein phosphatase-1G in response to adrenalin.
FEBS letters 1988;234(1):189-94.
1988: A A Chisholm; Philip Cohen
Identification of a third form of protein phosphatase 1 in rabbit skeletal muscle that is associated with myosin.
Biochimica et biophysica acta 1988;968(3):392-400.
1987: J Pitcher; Carl Smythe; D G Campbell; Philip Cohen
Identification of the 38-kDa subunit of rabbit skeletal muscle glycogen synthase as glycogenin.
European journal of biochemistry / FEBS 1987;169(3):497-502.
1987: Norbert Berndt; D G Campbell; F B Caudwell; Philip Cohen; E F da Cruz e Silva; O B da Cruz e Silva; Patricia T W Cohen
Isolation and sequence analysis of a cDNA clone encoding a type-1 protein phosphatase catalytic subunit: homology with protein phosphatase 2A.
FEBS letters 1987;223(2):340-6.
1987: Philip Cohen
Molecular mechanisms involved in the control of glycogenolysis in skeletal muscle by calcium ions and cyclic AMP.
Biochemical Society transactions 1987;15(5):999-1001.