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Howard Colby

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Howard D Colby; Penelope A Longhurst; Joseph M Burczynski; Jill R Hayes; Bing-Bing Yuan; Jeffrey V Voigt
Downregulation of CYP2D16 by ACTH in the guinea pig adrenal cortex: time course, reversibility, and mechanism of action.
Howard D Colby; D M Nowak; Penelope A Longhurst; X Zhang; Jill R Hayes; JM Voigt
Bufuralol metabolism by guinea pig adrenal and hepatic microsomes.
Joseph M Burczynski; S J Southard; Jill R Hayes; Penelope A Longhurst; Howard D Colby
Changes in mitochondrial and microsomal lipid peroxidation and fatty acid profiles in adrenal glands, testes, and livers from alpha-tocopherol-deficient rats.

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All Publications

2003: Howard D Colby; Penelope A Longhurst; Joseph M Burczynski; Jill R Hayes; Bing-Bing Yuan; Jeffrey V Voigt
Downregulation of CYP2D16 by ACTH in the guinea pig adrenal cortex: time course, reversibility, and mechanism of action.
Pharmacology 2003;67(3):121-7.
2001: Howard D Colby; D M Nowak; Penelope A Longhurst; X Zhang; Jill R Hayes; JM Voigt
Bufuralol metabolism by guinea pig adrenal and hepatic microsomes.
Pharmacology 2001;62(4):229-33.
2001: Joseph M Burczynski; S J Southard; Jill R Hayes; Penelope A Longhurst; Howard D Colby
Changes in mitochondrial and microsomal lipid peroxidation and fatty acid profiles in adrenal glands, testes, and livers from alpha-tocopherol-deficient rats.
Free radical biology & medicine 2001;30(9):1029-35.
2001: Joseph M Burczynski; Jill R Hayes; JM Voigt; Penelope A Longhurst; Howard D Colby
Suppression of lipid peroxidation in adrenal microsomes following ACTH administration to guinea pigs.
The Journal of endocrinology 2001;168(2):333-8.
2001: Bing-Bing Yuan; Ruy Tchao; JM Voigt; Howard D Colby
Maturational changes in CYP2D16 expression and xenobiotic metabolism in adrenal glands from male and female guinea pigs.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(2):194-9.
2000: Howard D Colby; Y Huang; Q Jiang; JM Voigt
Bimodal expression of CYP2D16 in the guinea pig adrenal cortex.
Pharmacology 2000;61(2):78-82.
1999: Joseph M Burczynski; Jill R Hayes; Penelope A Longhurst; Howard D Colby
Species differences in adrenal lipid peroxidation: role of alpha-tocopherol.
Free radical biology & medicine 1999;26(7-8):987-91.
1999: I B Feingold; Penelope A Longhurst; Howard D Colby
Effects of adrenocorticotropic hormone and dexamethasone on adrenal and hepatic alpha-tocopherol concentrations.
Free radical biology & medicine 1999;26(5-6):633-8.
1998: Bing-Bing Yuan; Ruy Tchao; Y Funae; JM Voigt; Howard D Colby
Effects of ACTH administration on zonation of the guinea pig adrenal cortex.
Molecular and cellular endocrinology 1998;146(1-2):129-36.
1998: Y Huang; Q Jiang; K M Debolt; JM Voigt; Howard D Colby
Strain differences in adrenal microsomal steroid metabolism in guinea pigs.
The Journal of steroid biochemistry and molecular biology 1998;64(5-6):305-11.
1998: M Soltis; Howard D Colby
Inhibition of testicular steroid metabolism by administration of 1-aminobenzotriazole to rats.
Pharmacology 1998;56(1):51-6.
1997: Bing-Bing Yuan; Ruy Tchao; JM Voigt; Howard D Colby
Localization of CYP2D16 in the guinea pig adrenal cortex by immunohistochemistry and in situ hybridization.
Molecular and cellular endocrinology 1997;134(2):139-46.
1996: Y Huang; Q Jiang; JM Voigt; K M Debolt; Howard D Colby
Strain differences in adrenal CYP2D16 expression in guinea pigs. Relationship to xenobiotic metabolism.
Biochemical pharmacology 1996;52(12):1925-9.
1996: Q Jiang; Y Huang; JM Voigt; K M DeBolt; S Kominami; S Takemori; Y Funae; Howard D Colby
Differential effects of adrenocorticotropin in vivo on cytochromes P4502D16 and P450c17 in the guinea pig adrenal cortex.
Endocrinology 1996;137(11):4811-6.
1996: Q Jiang; Y Huang; JM Voigt; B K DeBolt; S Kominami; S Takemori; Y Funae; Howard D Colby
Expression and zonal distribution of CYP2D16 in the guinea pig adrenal cortex: relationship to xenobiotic metabolism.
Molecular pharmacology 1996;49(3):458-64.
1996: Howard D Colby; L B LaCagnin; L E Los
Stimulation of microsomal spironolactone metabolism by reduced glutathione.
Pharmacology 1996;52(1):30-4.
1995: D Xu; JM Voigt; B A Mico; Howard D Colby
Inhibition of adrenal steroid metabolism by administration of 1-aminobenzotriazole to guinea pigs.
The Journal of steroid biochemistry and molecular biology 1995;54(5-6):281-5.
1995: Q Jiang; JM Voigt; Howard D Colby
Molecular cloning and sequencing of a guinea pig cytochrome P4502D (CYP2D16): high level expression in adrenal microsomes.
Biochemical and biophysical research communications 1995;209(3):1149-56.
1995: Howard D Colby; B Abbott; M Cachovic; K M Debolt; B A Mico
Inactivation of adrenal cytochromes P450 by 1-aminobenzotriazole. Divergence of in vivo and in vitro actions.
Biochemical pharmacology 1995;49(8):1057-62.
1995: Howard D Colby; I W Larson; C Kowalski; M Levitt
Zonal differences in adrenocortical lipid peroxidation: role of alpha-tocopherol.
Free radical biology & medicine 1995;18(2):373-6.
1994: L E Los; Steven M Pitzenberger; Harri G Ramjit; A B Coddington; Howard D Colby
Hepatic metabolism of spironolactone. Production of 3-hydroxy-thiomethyl metabolites.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(6):903-8.
1994: Howard D Colby; H Purcell; S Kominami; S Takemori; D C Kossor
Adrenal activation of carbon tetrachloride: role of microsomal P450 isozymes.
Toxicology 1994;94(1-3):31-40.
1994: D Xu; JM Voigt; B A Mico; S Kominami; S Takemori; Howard D Colby
Inhibition of adrenal cytochromes P450 by 1-aminobenzotriazole in vitro. Selectivity for xenobiotic metabolism.
Biochemical pharmacology 1994;48(7):1421-6.
1994: Howard D Colby
In vitro assessment of adrenocortical toxicity.
Journal of pharmacological and toxicological methods 1994;32(1):1-6.
1994: L E Los; Howard D Colby
Binding of spironolactone metabolites in vivo to renal mineralocorticoid receptors in guinea pigs.
Pharmacology 1994;48(2):86-92.
1993: L E Los; A B Coddington; Harri G Ramjit; Howard D Colby
Identification of spironolactone metabolites in plasma and target organs of guinea pigs.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(6):1086-90.
1993: Howard D Colby; M Levitt; J M Bergstrom; H Purcell
Maturational changes in steroidogenesis in the inner and outer zones of the guinea pig adrenal cortex.
The Journal of steroid biochemistry and molecular biology 1993;45(6):501-7.
1993: I B Feingold; P A Longhurst; Howard D Colby
Regulation of adrenal and hepatic alpha-tocopherol content by androgens and estrogens.
Biochimica et biophysica acta 1993;1176(1-2):192-6.
1993: Howard D Colby; M Levitt; I W Larson
Zonal differences in the thermal lability of adrenal microsomal monooxygenases.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(1):200-2.
1992: D C Kossor; S Kominami; S Takemori; Howard D Colby
Destruction of testicular cytochrome P-450 by 7 alpha-thiospironolactone is catalyzed by the 17 alpha-hydroxylase.
The Journal of steroid biochemistry and molecular biology 1992;42(3-4):421-4.
1992: Howard D Colby; M Levitt; M R Pope; P B Johnson
Differential effects of adrenocorticotropic hormone on steroid hydroxylase activities in the inner and outer zones of the guinea pig adrenal cortex.
The Journal of steroid biochemistry and molecular biology 1992;42(3-4):329-35.
1992: I B Feingold; Howard D Colby
Sex differences in adrenal and hepatic alpha-tocopherol concentrations in rats.
Pharmacology 1992;44(2):113-6.
1992: D C Kossor; Howard D Colby
Dose-dependent actions of spironolactone on the inner and outer zones of the guinea pig adrenal cortex.
Pharmacology 1992;45(1):27-33.
1991: K A Rourke; J M Bergstrom; I W Larson; Howard D Colby
Mechanism of action of spironolactone on cortisol production by guinea pig adrenocortical cells.
Molecular and cellular endocrinology 1991;81(1-3):127-34.
1991: D C Kossor; S Kominami; S Takemori; Howard D Colby
Role of the steroid 17 alpha-hydroxylase in spironolactone-mediated destruction of adrenal cytochrome P-450.
Molecular pharmacology 1991;40(2):321-5.
1991: Howard D Colby; P B Johnson; M R Pope
Mechanisms responsible for the thermal sensitivity of adrenal microsomal monooxygenases.
Drug metabolism and disposition: the biological fate of chemicals 1991;19(3):679-82.
1991: Howard D Colby; J P O'Donnell; N L Flowers; D C Kossor; P B Johnson; M Levitt
Relationship between covalent binding to microsomal protein and the destruction of adrenal cytochrome P-450 by spironolactone.
Toxicology 1991;67(2):143-54.
1990: K A Rourke; Howard D Colby
Spironolactone inhibition of cortisol production by guinea pig adrenocortical cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1990;22(11):573-5.
1990: D A Staats; D P Lohr; Howard D Colby
Effects of carbon tetrachloride administration to guinea pigs on cytochromes P-450 and antioxidant levels in the inner and outer zones of the adrenal cortex.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(4):543-5.
1989: J H Sherry; P B Johnson; M Levitt; J Bergstrom; Howard D Colby
Regional differences in adrenal activation of spironolactone: relationship to steroid 17 alpha-hydroxylase activity.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(6):709-10.
1989: L B LaCagnin; M Levitt; J M Bergstrom; Howard D Colby
Inhibition of adrenocortical, mitochondrial and microsomal monooxygenases by SU-10'603, a steroid 17 alpha-hydroxylase inhibitor.
Journal of steroid biochemistry 1989;33(4A):599-604.
1989: D A Staats; D P Lohr; Howard D Colby
alpha-Tocopherol depletion eliminates the regional differences in adrenal mitochondrial lipid peroxidation.
Molecular and cellular endocrinology 1989;62(2):189-95.
1989: D A Staats; Howard D Colby
Modulation of the effects of ascorbic acid on lipid peroxidation by tocopherol in adrenocortical mitochondria.
Journal of steroid biochemistry 1989;32(4):609-11.
1989: N L Flowers; J P O'Donnell; Howard D Colby
Spironolactone metabolism in target tissues. Characteristics of deacetylation in kidney, liver, adrenal cortex, and testes.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(2):186-9.
1988: D A Staats; D Lohr; Howard D Colby
Relationship between mitochondrial lipid peroxidation and alpha-tocopherol levels in the guinea-pig adrenal cortex.
Biochimica et biophysica acta 1988;961(3):279-84.
1988: D A Staats; D P Lohr; Howard D Colby
Effects of tocopherol depletion on the regional differences in adrenal microsomal lipid peroxidation and steroid metabolism.
Endocrinology 1988;123(2):975-80.
1988: Howard D Colby; L B Lacagnin; P A Longhurst
Changes in adrenocortical monooxygenase activities in alloxan-diabetic rabbits.
Journal of steroid biochemistry 1988;29(6):731-3.
1988: L B LaCagnin; P Patricoski; Howard D Colby
Inhibition of hepatic microsomal drug metabolism by the steroid hydroxylase inhibitor SU-10'603.
Biochemical pharmacology 1988;37(8):1625-8.
1988: N L Flowers; J H Sherry; J P O'Donnell; Howard D Colby
Adrenal mitochondrial metabolism of spironolactone. Absence of metabolic activation.
Biochemical pharmacology 1988;37(8):1591-5.
1988: J H Sherry; P B Johnson; Howard D Colby
Species differences in adrenal spironolactone metabolism: relationship to cytochrome P-450 destruction.
Biochemical pharmacology 1988;37(2):355-7.
1987: D A Staats; Howard D Colby
Regional differences in microsomal lipid peroxidation and antioxidant levels in the guinea pig adrenal cortex.
Journal of steroid biochemistry 1987;28(6):637-42.
1987: L B LaCagnin; P Lutsie; Howard D Colby
Conversion of spironolactone to 7 alpha-thiomethylspironolactone by hepatic and renal microsomes.
Biochemical pharmacology 1987;36(20):3439-44.
1987: L B LaCagnin; Howard D Colby; N S Dalal; J P O'Donnell
Metabolic activation of hydralazine by rat liver microsomes.
Biochemical pharmacology 1987;36(16):2667-72.
1987: Howard D Colby; M R Pope; P B Johnson; J H Sherry
Effects of cadmium in vitro on microsomal steroid metabolism in the inner and outer zones of the guinea pig adrenal cortex.
Journal of biochemical toxicology 1987;2():1-11.
1986: L B LaCagnin; Howard D Colby; J P O'Donnell
The oxidative metabolism of hydralazine by rat liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(5):549-54.
1986: P A Longhurst; L B LaCagnin; D A Staats; Howard D Colby
Changes in hepatic drug metabolism in alloxan-diabetic male rabbits.
Biochemical pharmacology 1986;35(10):1768-71.
1986: L B Lacagnin; Howard D Colby; J P O'Donnell
Separation and quantitation of hydralazine metabolites by high-performance liquid chromatography.
Journal of chromatography 1986;377():319-27.
1986: J H Sherry; J P O'Donnell; L Flowers; L B Lacagnin; Howard D Colby
Metabolism of spironolactone by adrenocortical and hepatic microsomes: relationship to cytochrome P-450 destruction.
The Journal of pharmacology and experimental therapeutics 1986;236(3):675-80.
1986: J H Sherry; J P O'Donnell; Howard D Colby
Separation of spironolactone and its biologically active sulfur-containing metabolites by high-performance liquid chromatography.
Journal of chromatography 1986;374(1):183-90.
1985: Howard D Colby; M R Pope; J S Zulkoski; P I Eacho
Strain differences in microsomal xenobiotic metabolism by adrenocortical inner and outer zones.
Drug metabolism and disposition: the biological fate of chemicals 1985;13(3):371-3.
1984: P I Eacho; P B Johnson; M R Pope; Howard D Colby
Regional differences in adrenocortical benzo[a]pyrene metabolism in guinea pigs.
Biochemical pharmacology 1984;33(11):1811-3.
1984: Howard D Colby; J S Zulkoski; P B Johnson; M R Pope; P R Miles
Sites of action of cadmium in vitro on hepatic, adrenal, and pulmonary microsomal monooxygenases in guinea pigs.
Toxicology and applied pharmacology 1984;73(1):110-8.
1983: Howard D Colby; J S Zulkoski; P B Johnson; M R Pope; P R Miles
The duration of exposure of microsomal preparations to cadmium or zinc in vitro influences the inhibition of mono-oxygenases.
Drug metabolism and disposition: the biological fate of chemicals 1983;11(1):67-9.
1982: Howard D Colby; P B Johnson; J S Zulkoski; M R Pope
Differential effects of adrenocorticotropic hormone on adrenal microsomal xenobiotic and steroid metabolism in guinea pigs.
Drug metabolism and disposition: the biological fate of chemicals 1982;10(4):326-9.
1982: Howard D Colby; P B Johnson; M R Pope; J S Zulkoski
Metabolism of benzo [a] pyrene by guinea pig adrenal and hepatic microsomes.
Biochemical pharmacology 1982;31(5):639-46.
1981: J H Sherry; J P O'Donnell; Howard D Colby
Conversion of spironolactone to an active metabolite in target tissues: formation of 7 alpha-thiospironolactone by microsomal preparations from guinea pig liver, adrenals, kidneys, and testes.
Life sciences 1981;29(26):2727-36.
1981: Howard D Colby; P B Johnson; J S Zulkoski; M R Pope; P R Miles
Comparative effects of cadmium, zinc, and lead in vitro on pulmonary, adrenal, and hepatic microsomal metabolism in the guinea pig.
Journal of toxicology and environmental health 1981;8(5-6):907-15.
1980: Howard D Colby; M L Marquess; P B Johnson; M R Pope
Effects of steroid hormones in vitro on adrenal xenobiotic metabolism in the guinea pig.
Biochemical pharmacology 1980;29(17):2373-7.
1980: Howard D Colby; M L Marquess; P B Johnson; M R Pope; P R Heaps
Comparative effects of mixed function oxidase inhibitors on adrenal and hepatic xenobiotic metabolism in the guinea pig.
Biochemical pharmacology 1980;29(6):951-3.