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Philip Cole

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Chemicals & Drugs

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Beverley M Dancy; Louis C Mahadevan; DAVID MEYERS; Chandrani Mukherjee; Daniel J Peterson; Minoru Yoshida; Jin Zhang; Young-Hoon Ahn; Jef Boeke; Erin M Bowers; Nicholas T Crump; Philip A Cole
Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition.
Wei Wei; Shanzhi Yan; Shawn Anderson; Sabrina Castellano; Carlos M Coelho; Philip A Cole; Michael S Kobor; Xiang Li; Antonello Mai; Roger Marek; DAVID MEYERS; Ciro Milite; Chandrani Mukherjee; dante rotili; Pankaj Sah; Gianluca Sbardella; Timothy W Bredy
p300/CBP-associated factor selectively regulates the extinction of conditioned fear.
Isabel Martinez Ferrando; Katie Herbst-Robinson; Harrys K C Jacob; Vikram Katju; Henrik Molina; Akhilesh Pandey; Jin Zhang; Jun Zhong; Ron Bose; Raghothama Chaerkady; Beverley M Dancy; Philip A Cole
Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics.

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All Publications

2012: Beverley M Dancy; Louis C Mahadevan; DAVID MEYERS; Chandrani Mukherjee; Daniel J Peterson; Minoru Yoshida; Jin Zhang; Young-Hoon Ahn; Jef Boeke; Erin M Bowers; Nicholas T Crump; Philip A Cole
Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition.
Chembiochem : a European journal of chemical biology 2012;13(14):2113-21.
2012: Wei Wei; Shanzhi Yan; Shawn Anderson; Sabrina Castellano; Carlos M Coelho; Philip A Cole; Michael S Kobor; Xiang Li; Antonello Mai; Roger Marek; DAVID MEYERS; Ciro Milite; Chandrani Mukherjee; dante rotili; Pankaj Sah; Gianluca Sbardella; Timothy W Bredy
p300/CBP-associated factor selectively regulates the extinction of conditioned fear.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(35):11930-41.
2012: Isabel Martinez Ferrando; Katie Herbst-Robinson; Harrys K C Jacob; Vikram Katju; Henrik Molina; Akhilesh Pandey; Jin Zhang; Jun Zhong; Ron Bose; Raghothama Chaerkady; Beverley M Dancy; Philip A Cole
Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics.
Molecular & cellular proteomics : MCP 2012;11(8):355-69.
2012: Yu Wang; DAVID MEYERS; London L P J Ooi; Han Chong Toh; Pierce Chow; Alexander Y F Chung; Philip A Cole; Caroline G L Lee
MicroRNA-224 is up-regulated in hepatocellular carcinoma through epigenetic mechanisms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(7):3032-41.
2012: Blair C R Dancy; Beverley M Dancy; William J Drury; Christine A Jelinek; Ananya Majumdar; Shonoi A Ming; Romeo Papazyan; Yan Sun; SEAN TAVERNA; Robert J Cotter; Philip A Cole
Azalysine analogues as probes for protein lysine deacetylation and demethylation.
Journal of the American Chemical Society 2012;134(11):5138-48.
2012: Mary Katherine Tarrant; Zhi Xie; Gai Yan; Natasha E Zachara; Heng Zhu; Seth Blackshaw; Jeffrey C Culhane; Felicia A Etzkorn; Christopher Gross; Gerald W Hart; Yoshitaka Ichikawa; Jun Seop Jeong; Yu Lin Jiang; Tatsuji Matsuoka; Jiang Qian; Hee-Sool Rho; Philip A Cole
Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis.
Nature chemical biology 2012;8(3):262-9.
2012: Martin S Taylor; Jef Boeke; Po-Yuan Hsiao; You Sang Hwang; Philip A Cole
Ghrelin O-acyltransferase assays and inhibition.
Methods in enzymology 2012;514():205-28.
2011: Zhihong Wang; Sarah Head; Kwangsoo Kim; Daniel J Leahy; Patti A Longo; Mary Katherine Tarrant; Philip A Cole
Mechanistic insights into the activation of oncogenic forms of EGF receptor.
Nature structural & molecular biology 2011;18(12):1388-93.
2011: Ying Zhang; Ronald J Hicks; Tadashi Honda; Young-Hoon Ahn; Ivor J Benjamin; Vittorio Calabrese; Philip A Cole; Albena T Dinkova-Kostova
HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway.
Chemistry & biology 2011;18(11):1355-61.
2011: Samuel L Collins; Jonathan D Powell; Young-Hoon Ahn; Katharine E Black; Yee Chan-Li; Philip A Cole; Maureen R Horton
Hyaluronan fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor.
American journal of respiratory cell and molecular biology 2011;45(4):675-83.
2011: Frédéric R Santer; Jan Bouchal; Ilaria T R Cavarretta; Philip A Cole; Holger H H Erb; Philipp P S Höschele; DAVID MEYERS; Su Jung Oh; Walther Parson; Zoran Culig
Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines.
Molecular cancer therapeutics 2011;10(9):1644-55.
2011: Lan Wang; Haiming Xu; Hao Xu; J Zhang; Xinyang Zhao; Fabiana Perna; Robert G Roeder; Xiao-Jian Sun; Francesca Voza; Ly Vu; Takashi Asai; Philip A Cole; Tony DeBlasio; Alexander Gural; Megan A Hatlen; Gang Huang; Yanwen Jiang; Fan Liu; Ari Melnick; Silvia Menendez; Stephen D Nimer
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation.
Science (New York, N.Y.) 2011;333(6043):765-9.
2011: Natalya A Smirnova; Rachel E Speer; Young-Hoon Ahn; Manuela Basso; Philip A Cole; Renee E Haskew-Layton; Dmitry M Hushpulian; Jimmy B Payappilly; John T Pinto; Ilay Rakhman; Rajiv R Ratan; Irina Gazaryan
Development of Neh2-luciferase reporter and its application for high throughput screening and real-time monitoring of Nrf2 activators.
Chemistry & biology 2011;18(6):752-65.
2011: Cheng-Ran Xu; Philip A Cole; DAVID MEYERS; Jay Kormish; Sharon Dent; Kenneth S Zaret
Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas.
Science (New York, N.Y.) 2011;332(6032):963-6.
2011: Roger Marek; Carlos M Coelho; Robert K P Sullivan; Danay Baker-Andresen; Xiang Li; Vikram Ratnu; Kevin J Dudley; DAVID MEYERS; Chandrani Mukherjee; Philip A Cole; Pankaj Sah; Timothy W Bredy
Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(20):7486-91.
2011: Nicholas T Crump; Catherine A Hazzalin; Erin M Bowers; Rhoda M Alani; Philip A Cole; Louis C Mahadevan
Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(19):7814-9.
2011: Lauren P Blair; Nathan L Avaritt; Rong Huang; Philip A Cole; SEAN TAVERNA; Alan J Tackett
MassSQUIRM: An assay for quantitative measurement of lysine demethylase activity.
Epigenetics : official journal of the DNA Methylation Society 2011;6(4):490-9.
2011: Yong Tang; Marc A Holbert; Neda Delgoshaie; Hugo Wurtele; Benoît Guillemette; Katrina Meeth; Hua Yuan; Paul Drogaris; Eun-Hye Lee; Chantal Durette; Pierre Thibault; Alain Verreault; Philip A Cole; Ronen Marmorstein
Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation.
Structure (London, England : 1993) 2011;19(2):221-31.
2011: Kannan R Karukurichi; Philip A Cole
Probing the reaction coordinate of the p300/CBP histone acetyltransferase with bisubstrate analogs.
Bioorganic chemistry 2011;39(1):42-7.
2010: SEAN TAVERNA; Philip A Cole
Drug discovery: Reader's block.
Nature 2010;468(7327):1050-1.
2010: Brad P Barnett; You Sang Hwang; Martin S Taylor; Henriette Kirchner; Paul T Pfluger; Vincent Bernard; Yu-Yi Lin; Erin M Bowers; Chandrani Mukherjee; Woo-Jin Song; Patti A Longo; Daniel J Leahy; Mehboob A Hussain; Matthias H Tschöp; Jef Boeke; Philip A Cole
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor.
Science (New York, N.Y.) 2010;330(6011):1689-92.
2010: M L Bellows; M S Taylor; Philip A Cole; L Shen; Robert Siliciano; H K Fung; Christodoulos A Floudas
Discovery of entry inhibitors for HIV-1 via a new de novo protein design framework.
Biophysical journal 2010;99(10):3445-53.
2010: Sang-Won Min; Seo-Hyun Cho; Yungui Zhou; Sebastian Schroeder; Vahram Haroutunian; William W Seeley; Eric J Huang; Yong Shen; Eliezer Masliah; Chandrani Mukherjee; DAVID MEYERS; Philip A Cole; Melanie Ott; Li Gan
Acetylation of tau inhibits its degradation and contributes to tauopathy.
Neuron 2010;67(6):953-66.
2010: Nicolas Reynoird; Brian E Schwartz; Manuela Delvecchio; Karin Sadoul; DAVID MEYERS; Chandrani Mukherjee; Cécile Caron; Hiroshi Kimura; Sophie Rousseaux; Philip A Cole; Daniel Panne; Christopher A French; Saadi Khochbin
Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains.
The EMBO journal 2010;29(17):2943-52.
2010: Rong Huang; Marc A Holbert; Mary Katherine Tarrant; Sandrine Curtet; David Colquhoun; Beverley M Dancy; Blair C Dancy; You Sang Hwang; Yong Tang; Katrina Meeth; Ronen Marmorstein; Robert N Cole; Saadi Khochbin; Philip A Cole
Site-specific introduction of an acetyl-lysine mimic into peptides and proteins by cysteine alkylation.
Journal of the American Chemical Society 2010;132(29):9986-7.
2010: Rong Huang; Isabel Martinez-Ferrando; Philip A Cole
Enhanced interrogation: emerging strategies for cell signaling inhibition.
Nature structural & molecular biology 2010;17(6):646-9.
2010: Erin M Bowers; Gai Yan; Chandrani Mukherjee; Andrew Orry; Ling Wang; Marc A Holbert; Nicholas T Crump; Catherine A Hazzalin; Glen Liszczak; Hua Yuan; Cecilia Larocca; S Adrian Saldanha; Ruben Abagyan; Yan Sun; DAVID MEYERS; Ronen Marmorstein; Louis C Mahadevan; Rhoda M Alani; Philip A Cole
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.
Chemistry & biology 2010;17(5):471-82.
2010: Young-Hoon Ahn; You Sang Hwang; Hua Liu; Xiu Jun Wang; Ying Zhang; Katherine K Stephenson; Tatiana N Boronina; Robert N Cole; Albena T Dinkova-Kostova; Paul Talalay; Philip A Cole
Electrophilic tuning of the chemoprotective natural product sulforaphane.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(21):9590-5.
2010: Prashant Mali; Bin-Kuan Chou; Jonathan Yen; Zhaohui Ye; Jizhong Zou; Sarah Dowey; Robert A Brodsky; Joyce E Ohm; Wayne Yu; Stephen B Baylin; Kosuke Yusa; Allan Bradley; DAVID MEYERS; Chandrani Mukherjee; Philip A Cole; Linzhao Cheng
Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.
Stem cells (Dayton, Ohio) 2010;28(4):713-20.
2010: Jeffrey C Culhane; Dongqing Wang; Paul M Yen; Philip A Cole
Comparative analysis of small molecules and histone substrate analogues as LSD1 lysine demethylase inhibitors.
Journal of the American Chemical Society 2010;132(9):3164-76.
2010: Kannan R Karukurichi; Ling Wang; Lerna Uzasci; Cara Marie Manlandro; Qing Wang; Philip A Cole
Analysis of p300/CBP histone acetyltransferase regulation using circular permutation and semisynthesis.
Journal of the American Chemical Society 2010;132(4):1222-3.
2009: Lassad Oussaief; Aurélie Hippocrate; Vanessa Ramirez; Aurore Rampanou; Wei Zhang; DAVID MEYERS; Philip A Cole; RIDHA KHELIFA; Irène Joab
Phosphatidylinositol 3-kinase/Akt pathway targets acetylation of Smad3 through Smad3/CREB-binding protein interaction: contribution to transforming growth factor beta1-induced Epstein-Barr virus reactivation.
The Journal of biological chemistry 2009;284(36):23912-24.
2009: Chen Qiu; Mary K Tarrant; Tatiana Boronina; Patti A Longo; Jennifer M Kavran; Robert N Cole; Philip A Cole; Daniel J Leahy
In vitro enzymatic characterization of near full length EGFR in activated and inhibited states.
Biochemistry 2009;48(28):6624-32.
2009: D A Herrera; J Anavian; I S Tarkin; B A Armitage; L K Schroder; Philip A Cole
Delayed operative management of fractures of the scapula.
The Journal of bone and joint surgery. British volume 2009;91(5):619-26.
2009: Magnus L Hansson; Anita E Popko-Scibor; Mariana Saint Just Ribeiro; Beverley M Dancy; Mikael J Lindberg; Philip A Cole; Annika E Wallberg
The transcriptional coactivator MAML1 regulates p300 autoacetylation and HAT activity.
Nucleic acids research 2009;37(9):2996-3006.
2009: Dongqing Wang; Xianmin Xia; Ying Liu; Alexis Oetting; Robert L Walker; Yuelin Zhu; Paul Meltzer; Philip A Cole; Yun-Bo Shi; Paul M Yen
Negative regulation of TSHalpha target gene by thyroid hormone involves histone acetylation and corepressor complex dissociation.
Molecular endocrinology (Baltimore, Md.) 2009;23(5):600-9.
2009: Kathryn Elizabeth Muratore; Markus A Seeliger; Zhihong Wang; Dina Fomina; Johnathan Neiswinger; James J Havranek; David Baker; John Kuriyan; Philip A Cole
Comparative analysis of mutant tyrosine kinase chemical rescue.
Biochemistry 2009;48(15):3378-86.
2009: Lawrence szewczuk; Mary Katherine Tarrant; Philip A Cole
Protein phosphorylation by semisynthesis: from paper to practice.
Methods in enzymology 2009;462():1-24.
2009: Mary Katherine Tarrant; Philip A Cole
The chemical biology of protein phosphorylation.
Annual review of biochemistry 2009;78():797-825.
2008: Ling Wang; Yong Tang; Philip A Cole; Ronen Marmorstein
Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function.
Current opinion in structural biology 2008;18(6):741-7.
2008: Yi Liu; Renaud Dentin; Danica Chen; Susan Hedrick; Kim Ravnskjaer; Simon Schenk; Jill Milne; DAVID MEYERS; Philip A Cole; John Yates; Jerrold Olefsky; Leonard Guarente; Marc Montminy
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.
Nature 2008;456(7219):269-73.
2008: Philip A Cole
Chemical probes for histone-modifying enzymes.
Nature chemical biology 2008;4(10):590-7.
2008: Lawrence szewczuk; Mary K Tarrant; Vedangi Sample; William J Drury; Jin Zhang; Philip A Cole
Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis.
Biochemistry 2008;47(39):10407-19.
2008: Nicholas M Levinson; Markus A Seeliger; Philip A Cole; John Kuriyan
Structural basis for the recognition of c-Src by its inactivator Csk.
Cell 2008;134(1):124-34.
2008: Yong Tang; Marc A Holbert; Hugo Wurtele; Katrina Meeth; Walter Rocha; Marlene Gharib; Eva Jiang; Pierre Thibault; Alain Verreault; Alain Verrault; Philip A Cole; Ronen Marmorstein
Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP.
Nature structural & molecular biology 2008;15(7):738-45.
2008: KERRY PAUMI; Sidhartha Chaudhury; Blair C R Dancy; Jeffrey J Gray; Philip A Cole
Analysis of protein kinase autophosphorylation using expressed protein ligation and computational modeling.
Journal of the American Chemical Society 2008;130(17):5667-9.
2008: Chen Qiu; Mary K Tarrant; Sung Hee Choi; Aruna Sathyamurthy; Ron Bose; Sudeep Banjade; Ashutosh Pal; William G Bornmann; Mark A Lemmon; Philip A Cole; Daniel J Leahy
Mechanism of activation and inhibition of the HER4/ErbB4 kinase.
Structure (London, England : 1993) 2008;16(3):460-7.
2008: Xin Liu; Ling Wang; Kehao Zhao; Paul R Thompson; You Sang Hwang; Ronen Marmorstein; Philip A Cole
The structural basis of protein acetylation by the p300/CBP transcriptional coactivator.
Nature 2008;451(7180):846-50.
2008: M Suresh; Mukhtar Ahmed; Natalie G Ahn; Hainard Alexandre; Ramars Amanchy; Philip C Andrews; Joel S Bader; Brian M Balgley; Marcus Bantscheff; Keiryn Bennett; Erik Björling; Blagoy Blagoev; Ron Bose; Samir K Brahmachari; Alma S Burlingame; Xosé R Bustelo; Gerard Cagney; Greg T Cantin; Helene L Cardasis; Julio E Celis; Raghothama Chaerkady; Feixia Chu; Philip A Cole; Catherine E Costello; Robert J Cotter; David Crockett; James P DeLany; Angelo M DeMarzo; Leroi V DeSouza; Eric W Deutsch; Eric Dransfield; Gerard Drewes; Arnaud Droit; Michael J Dunn; Kojo Seys John Elenitoba-Johnson; Rob M Ewing; Jennifer E Van Eyk; Vitor Faca; Jayson Falkner; Xiangming Fang; Catherine Fenselau; Daniel Figeys; Pierre Gagné; Cecilia Gelfi; Kris Gevaert; Jeffrey M Gimble; Florian Gnad; renu goel; Pavel Gromov; Samir M Hanash; William S Hancock; H C Harsha; Gerald W Hart; Faith Hays; Fuchu He; Prashantha Hebbar; Kenny Helsens; Heiko Hermeking; Winston Hide; Karin Hjernø; Denis F Hochstrasser; Oliver Hofmann; David M Horn; Ralph Hruban; Nieves Ibarrola; Peter James; Ole N Jensen; Pia Hønnerup Jensen; Peter Jung; Richard Kumaran Kandasamy; Indu Kheterpal; Reiko F Kikuno; Ulrike Korf; Roman Körner; Bernhard Kuster; Min-Seok Kwon; Hyoung-Joo Lee; Young-Jin Lee; Michael Lefevre; Minna Lehvaslaiho; Pierre Lescuyer; Fredrik Levander; Megan S Lim; Christian Löbke; Joseph A Loo; Matthias Mann; Lennart Martens; Juan Martinez-Heredia; Mark McComb; James McRedmond; Alexander Mehrle; Rajasree Menon; Christine A Miller; Harald Mischak; S Sujatha Mohan; Riaz Mohmood; Henrik Molina; Michael F Moran; James D Morgan; Robert Moritz; Martine Morzel; David C Muddiman; Anuradha Nalli; J Daniel Navarro; Thomas A Neubert; Osamu Ohara; Rafael Oliva; Gilbert S Omenn; Masaaki Oyama; Young-Ki Paik; Kyla Pennington; Rainer Pepperkok; Balamurugan Periaswamy; Emanuel F Petricoin; Guy G Poirier; T S Keshava Prasad; Samuel O Purvine; B Abdul Rahiman; Prasanna Ramachandran; Y L Ramachandra; Robert H Rice; Jens Rick; Ragna H Ronnholm; Johanna Salonen; jean-charles sanchez; Thierry Sayd; Beerelli Seshi; Kripa Shankari; Shi Jun Sheng; Vivekananda Shetty; K Shivakumar; Richard J Simpson; Ravi Sirdeshmukh; K W Michael Siu; Jeffrey Smith; Richard D Smith; David J States; Sumio Sugano; Matthew Sullivan; Giulio Superti-Furga; Maarit Takatalo; Visith Thongboonkerd; Jonathan C Trinidad; Mathias Uhlen; Joël Vandekerckhove; Julian Vasilescu; Timothy D Veenstra; José-Manuel Vidal-Taboada; Mauno Vihinen; Robin Wait; Xiaoyue Wang; Stefan Wiemann; Billy Wu; Tao Xu; John R Yates; Jun Zhong; Ming Zhou; Yunping Zhu; Petra Zurbig; Akhilesh Pandey
Human Proteinpedia enables sharing of human protein data.
Nature biotechnology 2008;26(2):164-7.
2007: Xuewu Zhang; KERRY PAUMI; Ron Bose; Natalia Jura; Philip A Cole; John Kuriyan
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
Nature 2007;450(7170):741-4.
2007: Lawrence szewczuk; S Adrian Saldanha; Surajit Ganguly; Erin M Bowers; Margarita Javoroncov; Balasubramanyam Karanam; Jeffrey C Culhane; Marc A Holbert; David Klein; Ruben Abagyan; Philip A Cole
De novo discovery of serotonin N-acetyltransferase inhibitors.
Journal of medicinal chemistry 2007;50(22):5330-8.
2007: Jeffrey C Culhane; Philip A Cole
LSD1 and the chemistry of histone demethylation.
Current opinion in chemical biology 2007;11(5):561-8.
2007: Niall S Kenneth; Ben A Ramsbottom; Natividad Gomez-Roman; Lynne Marshall; Philip A Cole; Robert J White
TRRAP and GCN5 are used by c-Myc to activate RNA polymerase III transcription.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(38):14917-22.
2007: Kathryn Elizabeth Muratore; Philip A Cole
A lock on phosphotyrosine signaling.
ACS chemical biology 2007;2(7):454-6.
2007: Balasubramanyam Karanam; Ling Wang; Dongxia Wang; Xin Liu; Ronen Marmorstein; Robert J Cotter; Philip A Cole
Multiple roles for acetylation in the interaction of p300 HAT with ATF-2.
Biochemistry 2007;46(28):8207-16.
2007: Maojun Yang; Jeffrey C Culhane; Lawrence szewczuk; Pegah R Jalili; Haydn L Ball; Mischa Machius; Philip A Cole; Hongtao Yu
Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine.
Biochemistry 2007;46(27):8058-65.
2007: Xiaoyi Hu; Yongjun Dang; Karen Tenney; Phillip Crews; Chiawei W Tsai; Katherine M Sixt; Philip A Cole; Jun O Liu
Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases.
Chemistry & biology 2007;14(7):764-74.
2007: Lawrence szewczuk; Jeffrey C Culhane; Maojun Yang; Ananya Majumdar; Hongtao Yu; Philip A Cole
Mechanistic analysis of a suicide inactivator of histone demethylase LSD1.
Biochemistry 2007;46(23):6892-902.
2007: Maojun Yang; Jeffrey C Culhane; Lawrence szewczuk; Christian B Gocke; Chad A Brautigam; Diana R Tomchick; Mischa Machius; Philip A Cole; Hongtao Yu
Structural basis of histone demethylation by LSD1 revealed by suicide inactivation.
Nature structural & molecular biology 2007;14(6):535-9.
2007: You Sang Hwang; Surajit Ganguly; Anthony K Ho; David Klein; Philip A Cole
Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug.
Bioorganic & medicinal chemistry 2007;15(5):2147-55.
2007: You Sang Hwang; Paul R Thompson; Ling Wang; Lihua Jiang; Neil L Kelleher; Philip A Cole
A selective chemical probe for coenzyme A-requiring enzymes.
Angewandte Chemie (International ed. in English) 2007;46(40):7621-4.
2006: Balasubramanyam Karanam; Lihua Jiang; Ling Wang; Neil L Kelleher; Philip A Cole
Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation.
The Journal of biological chemistry 2006;281(52):40292-301.
2006: Ron Bose; Marc A Holbert; KERRY PAUMI; Philip A Cole
Protein tyrosine kinase-substrate interactions.
Current opinion in structural biology 2006;16(6):668-75.
2006: Robert Cheng; Martin E M Noble; Vicky Skamnaki; Nick R Brown; Edward D Lowe; Luke Kontogiannis; Kui Shen; Philip A Cole; Giuliano Siligardi; Louise N Johnson
The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.
The Journal of biological chemistry 2006;281(32):23167-79.
2006: Ron Bose; Henrik Molina; A Scott Patterson; John K Bitok; Balamurugan Periaswamy; Joel S Bader; Akhilesh Pandey; Philip A Cole
Phosphoproteomic analysis of Her2/neu signaling and inhibition.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):9773-8.
2006: Xuewu Zhang; Jodi Gureasko; Kui Shen; Philip A Cole; John Kuriyan
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.
Cell 2006;125(6):1137-49.
2006: Nicholas M Levinson; Olga Kuchment; Kui Shen; Matthew Adam Young; Michael Koldobskiy; Martin Karplus; Philip A Cole; John Kuriyan
A Src-like inactive conformation in the abl tyrosine kinase domain.
PLoS biology 2006;4(5):e144.
2006: Jeffrey C Culhane; Lawrence szewczuk; Xin Liu; Guoping Da; Ronen Marmorstein; Philip A Cole
A mechanism-based inactivator for histone demethylase LSD1.
Journal of the American Chemical Society 2006;128(14):4536-7.
2006: Dirk Schwarzer; Zhongsen Zhang; Weiping Zheng; Philip A Cole
Negative regulation of a protein tyrosine phosphatase by tyrosine phosphorylation.
Journal of the American Chemical Society 2006;128(13):4192-3.
2006: Yingfeng Qiao; Henrik Molina; Akhilesh Pandey; Jin Zhang; Philip A Cole
Chemical rescue of a mutant enzyme in living cells.
Science (New York, N.Y.) 2006;311(5765):1293-7.
2005: Kui Shen; Aliya C Hines; Dirk Schwarzer; KERRY PAUMI; Philip A Cole
Protein kinase structure and function analysis with chemical tools.
Biochimica et biophysica acta 2005;1754(1-2):65-78.
2005: Yujun Zheng; Karanam Balasubramanyam; Marek Cebrat; Donald Buck; Fabien Guidez; Arthur Zelent; Rhoda M Alani; Philip A Cole
Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor.
Journal of the American Chemical Society 2005;127(49):17182-3.
2005: Dirk Schwarzer; Philip A Cole
Protein semisynthesis and expressed protein ligation: chasing a protein's tail.
Current opinion in chemical biology 2005;9(6):561-9.
2005: Bogdan Lewczuk; Weiping Zheng; Magdalena Prusik; Philip A Cole; Barbara Przybylska-Gornowicz
N-bromoacetyltryptamine strongly and reversibly inhibits in vitro melatonin secretion from mammalian pinealocytes.
Neuro endocrinology letters 2005;26(5):581-92.
2005: Joanne Cleary; Kajal V Sitwala; Michael S Khodadoust; Roland P S Kwok; Nirit Mor-Vaknin; Marek Cebrat; Philip A Cole; David M Markovitz
p300/CBP-associated factor drives DEK into interchromatin granule clusters.
The Journal of biological chemistry 2005;280(36):31760-7.
2005: Yujun Zheng; Fatemah Mamdani; Dmitri Toptygin; Ludwig Brand; James T Stivers; Philip A Cole
Fluorescence analysis of a dynamic loop in the PCAF/GCN5 histone acetyltransferase.
Biochemistry 2005;44(31):10501-9.
2005: Aliya C Hines; Keykavous Parang; Ronald A Kohanski; Stevan Hubbard; Philip A Cole
Bisubstrate analog probes for the insulin receptor protein tyrosine kinase: molecular yardsticks for analyzing catalytic mechanism and inhibitor design.
Bioorganic chemistry 2005;33(4):285-97.
2005: Fabien Guidez; Louise Howell; Mark Isalan; Marek Cebrat; Rhoda M Alani; Sarah Ivins; Itsaso Hormaeche; Melanie J McConnell; Sarah Pierce; Philip A Cole; Jonathan D Licht; Arthur Zelent
Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein.
Molecular and cellular biology 2005;25(13):5552-66.
2005: Dongxia Wang; Paul Thompson; Philip A Cole; Robert J Cotter
Structural analysis of a highly acetylated protein using a curved-field reflectron mass spectrometer.
Proteomics 2005;5(9):2288-96.
2005: Weiping Zheng; Dirk Schwarzer; Aaron Lebeau; joan weller; David Klein; Philip A Cole
Cellular stability of serotonin N-acetyltransferase conferred by phosphonodifluoromethylene alanine (Pfa) substitution for Ser-205.
The Journal of biological chemistry 2005;280(11):10462-7.
2005: Edwin Cheung; Mari Luz Acevedo; Philip A Cole; W Lee Kraus
Altered pharmacology and distinct coactivator usage for estrogen receptor-dependent transcription through activating protein-1.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):559-64.
2005: Ho-Geun Yoon; Youngsok Choi; Philip A Cole; Jiemin Wong
Reading and function of a histone code involved in targeting corepressor complexes for repression.
Molecular and cellular biology 2005;25(1):324-35.
2004: Yujiang Shi; Fei Lan; Caitlin Matson; Peter Mulligan; Johnathan R Whetstine; Philip A Cole; Robert A Casero; Yang Shi
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
Cell 2004;119(7):941-53.
2004: Vatsala Sagar; Weiping Zheng; Paul R Thompson; Philip A Cole
Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors.
Bioorganic & medicinal chemistry 2004;12(12):3383-90.
2004: Aliya C Hines; Philip A Cole
Design, synthesis, and characterization of an ATP-peptide conjugate inhibitor of protein kinase A.
Bioorganic & medicinal chemistry letters 2004;14(11):2951-4.
2004: You Sang Hwang; Philip A Cole
Efficient synthesis of phosphorylated prodrugs with bis(POM)-phosphoryl chloride.
Organic letters 2004;6(10):1555-6.
2004: Paul R Thompson; Dongxia Wang; Ling Wang; Marcella Fulco; Natalia Pediconi; Dianzheng Zhang; Woojin An; Qingyuan Ge; Robert G Roeder; Jiemin Wong; Massimo Levrero; Vittorio Sartorelli; Robert J Cotter; Philip A Cole
Regulation of the p300 HAT domain via a novel activation loop.
Nature structural & molecular biology 2004;11(4):308-15.
2004: Christopher J Farrell; Jae Myun Lee; Eui-Cheol Shin; Marek Cebrat; Philip A Cole; S Diane Hayward
Inhibition of Epstein-Barr virus-induced growth proliferation by a nuclear antigen EBNA2-TAT peptide.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4625-30.
2004: Melanie Ott; Alexander Dorr; Claudia Hetzer-Egger; Katrin Kaehlcke; Martina Schnolzer; Peter Henklein; Philip A Cole; Ming-Ming Zhou; Eric Verdin
Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation.
Novartis Foundation symposium 2004;259():182-93; discussion 193-6, 223-5.
2004: Yujun Zheng; Paul R Thompson; Marek Cebrat; Ling Wang; Meghann K Devlin; Rhoda M Alani; Philip A Cole
Selective HAT inhibitors as mechanistic tools for protein acetylation.
Methods in enzymology 2004;376():188-99.
2003: Kui Shen; Philip A Cole
Conversion of a tyrosine kinase protein substrate to a high affinity ligand by ATP linkage.
Journal of the American Chemical Society 2003;125(52):16172-3.
2003: Weiping Zheng; Zhongsen Zhang; Surajit Ganguly; joan weller; David Klein; Philip A Cole
Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation.
Nature structural biology 2003;10(12):1054-7.
2003: Philip A Cole; Kui Shen; Yingfeng Qiao; Dongxia Wang
Protein tyrosine kinases Src and Csk: a tail's tale.
Current opinion in chemical biology 2003;7(5):580-5.
2003: Weiping Zheng; Philip A Cole
Novel bisubstrate analog inhibitors of serotonin N-acetyltransferase: the importance of being neutral.
Bioorganic chemistry 2003;31(5):398-411.
2003: Marek Cebrat; Cheol M Kim; Paul R Thompson; Matthew Daugherty; Philip A Cole
Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300.
Bioorganic & medicinal chemistry 2003;11(15):3307-13.
2003: Katrin Kaehlcke; Alexander Dorr; Claudia Hetzer-Egger; veronique kiermer; Peter Henklein; Martina Schnoelzer; Erwann P Loret; Philip A Cole; Eric Verdin; Melanie Ott
Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation.
Molecular cell 2003;12(1):167-76.
2003: Kara A Scheibner; Zhongsen Zhang; Philip A Cole
Merging fluorescence resonance energy transfer and expressed protein ligation to analyze protein-protein interactions.
Analytical biochemistry 2003;317(2):226-32.
2003: Philip A Cole; Aliya D Courtney; Kui Shen; Zhongsen Zhang; Yingfeng Qiao; Wei Lu; Daniel M Williams
Chemical approaches to reversible protein phosphorylation.
Accounts of chemical research 2003;36(6):444-52.
2003: Wei Lu; Kui Shen; Philip A Cole
Chemical dissection of the effects of tyrosine phosphorylation of SHP-2.
Biochemistry 2003;42(18):5461-8.
2003: Zhi-Qing Huang; Jiwen Li; Laurent M Sachs; Philip A Cole; Jiemin Wong
A role for cofactor-cofactor and cofactor-histone interactions in targeting p300, SWI/SNF and Mediator for transcription.
The EMBO journal 2003;22(9):2146-55.
2003: Sara A Georges; Holli A Giebler; Philip A Cole; Karolin Luger; Paul J Laybourn; Jennifer K Nyborg
Tax recruitment of CBP/p300, via the KIX domain, reveals a potent requirement for acetyltransferase activity that is chromatin dependent and histone tail independent.
Molecular and cellular biology 2003;23(10):3392-404.
2003: Kathleen C Lee; Jiwen Li; Philip A Cole; Jiemin Wong; W Lee Kraus
Transcriptional activation by thyroid hormone receptor-beta involves chromatin remodeling, histone acetylation, and synergistic stimulation by p300 and steroid receptor coactivators.
Molecular endocrinology (Baltimore, Md.) 2003;17(5):908-22.
2003: Zhongsen Zhang; Kui Shen; Wei Lu; Philip A Cole
The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation.
The Journal of biological chemistry 2003;278(7):4668-74.
2002: Debdutta Bandyopadhyay; Nihal A Okan; Elise Bales; Lucia Nascimento; Philip A Cole; Estela E Medrano
Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes.
Cancer research 2002;62(21):6231-9.
2002: Arienne N Poux; Marek Cebrat; Cheol M Kim; Philip A Cole; Ronen Marmorstein
Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14065-70.
2002: Dongxia Wang; Walter J Esselman; Philip A Cole
Substrate conformational restriction and CD45-catalyzed dephosphorylation of tail tyrosine-phosphorylated Src protein.
The Journal of biological chemistry 2002;277(43):40428-33.
2002: Hanxin Lu; Cynthia A Pise-Masison; Terace M Fletcher; R Louis Schiltz; Akhilesh K Nagaich; Michael F Radonovich; Gordon Hager; Philip A Cole; John N Brady
Acetylation of nucleosomal histones by p300 facilitates transcription from tax-responsive human T-cell leukemia virus type 1 chromatin template.
Molecular and cellular biology 2002;22(13):4450-62.
2002: Keykavous Parang; Jeffrey A Kohn; S Adrian Saldanha; Philip A Cole
Development of photo-crosslinking reagents for protein kinase-substrate interactions.
FEBS letters 2002;520(1-3):156-60.
2002: William Lowry; Jianyun Huang; Yong-Chao Ma; Shariq Ali; Dongxia Wang; Daniel M Williams; Masato Okada; Philip A Cole; Xin-Yun Huang
Csk, a critical link of g protein signals to actin cytoskeletal reorganization.
Developmental cell 2002;2(6):733-44.
2002: Weiping Zheng; Philip A Cole
Serotonin N-acetyltransferase: mechanism and inhibition.
Current medicinal chemistry 2002;9(12):1187-99.
2002: Daniel M Williams; Philip A Cole
Proton demand inversion in a mutant protein tyrosine kinase reaction.
Journal of the American Chemical Society 2002;124(21):5956-7.
2002: Kara A Scheibner; Jacqueline De Angelis; Stephen K Burley; Philip A Cole
Investigation of the roles of catalytic residues in serotonin N-acetyltransferase.
The Journal of biological chemistry 2002;277(20):18118-26.
2002: Kotha Subbaramaiah; Philip A Cole; Andrew J Dannenberg
Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms.
Cancer research 2002;62(9):2522-30.
2002: Eva Wolf; Jacqueline De Angelis; Ehab M Khalil; Philip A Cole; Stephen K Burley
X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition.
Journal of molecular biology 2002;317(2):215-24.
2002: Keykavous Parang; Philip A Cole
Designing bisubstrate analog inhibitors for protein kinases.
Pharmacology & therapeutics 2002;93(2-3):145-57.
2002: Antonio Costanzo; Paola Merlo; Natalia Pediconi; Marcella Fulco; Vittorio Sartorelli; Philip A Cole; Giulia Fontemaggi; Maurizio Fanciulli; Louis Schiltz; Giovanni Blandino; Clara Balsano; Massimo Levrero
DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.
Molecular cell 2002;9(1):175-86.
2001: Anna Polesskaya; Irina Naguibneva; Lauriane Fritsch; Arnaud Duquet; Slimane Ait-Si-Ali; SLIMANE AIT-SI-ALI; Arlette Vervisch; Linda L Pritchard; Philip A Cole; Annick Harel-Bellan
CBP/p300 and muscle differentiation: no HAT, no muscle.
The EMBO journal 2001;20(23):6816-25.
2001: Hiroshi Asahara; B Santoso; Ernesto Guzman; Keyong Du; Philip A Cole; I Davidson; Marc Montminy
Chromatin-dependent cooperativity between constitutive and inducible activation domains in CREB.
Molecular and cellular biology 2001;21(23):7892-900.
2001: Alexander Shekhtman; Ranajeet Ghose; D Wang; Philip A Cole; David Cowburn
Novel mechanism of regulation of the non-receptor protein tyrosine kinase Csk: insights from NMR mapping studies and site-directed mutagenesis.
Journal of molecular biology 2001;314(1):129-38.
2001: Wei Lu; D Gong; D Bar-Sagi; Philip A Cole
Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling.
Molecular cell 2001;8(4):759-69.
2001: D Wang; Philip A Cole
Protein tyrosine kinase Csk-catalyzed phosphorylation of Src containing unnatural tyrosine analogues.
Journal of the American Chemical Society 2001;123(37):8883-6.
2001: Paul R Thompson; H Kurooka; Y Nakatani; Philip A Cole
Transcriptional coactivator protein p300. Kinetic characterization of its histone acetyltransferase activity.
The Journal of biological chemistry 2001;276(36):33721-9.
2001: Cheol M Kim; Philip A Cole
Bisubstrate ketone analogues as serotonin N-acetyltransferase inhibitors.
Journal of medicinal chemistry 2001;44(15):2479-85.
2001: Paul R Thompson; Philip A Cole
Probing the mechanism of enzymatic phosphoryl transfer with a chemical trick.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8170-1.
2001: D M Williams; Philip A Cole
Kinase chips hit the proteomics era.
Trends in biochemical sciences 2001;26(5):271-3.
2001: Weiping Zheng; Kara A Scheibner; A K Ho; Philip A Cole
Mechanistic studies on the alkyltransferase activity of serotonin N-acetyltransferase.
Chemistry & biology 2001;8(4):379-89.
2001: Dongxia Wang; X Y Huang; Philip A Cole
Molecular determinants for Csk-catalyzed tyrosine phosphorylation of the Src tail.
Biochemistry 2001;40(7):2004-10.
2001: Keykavous Parang; Jeffrey H Till; AJ Ablooglu; Ronald A Kohanski; Stevan Hubbard; Philip A Cole
Mechanism-based design of a protein kinase inhibitor.
Nature structural biology 2001;8(1):37-41.
2000: D M Williams; Dongxia Wang; Philip A Cole
Chemical rescue of a mutant protein-tyrosine kinase.
The Journal of biological chemistry 2000;275(49):38127-30.
2000: AJ Ablooglu; Jeffrey H Till; K Kim; Keykavous Parang; Philip A Cole; Stevan Hubbard; Ronald A Kohanski
Probing the catalytic mechanism of the insulin receptor kinase with a tetrafluorotyrosine-containing peptide substrate.
The Journal of biological chemistry 2000;275(39):30394-8.
2000: TK Kundu; Vikas Palhan; Z Wang; Woojin An; Philip A Cole; Robert G Roeder
Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300.
Molecular cell 2000;6(3):551-61.
2000: OD Lau; A D Courtney; A Vassilev; L A Marzilli; Robert J Cotter; Y Nakatani; Philip A Cole
p300/CBP-associated factor histone acetyltransferase processing of a peptide substrate. Kinetic analysis of the catalytic mechanism.
The Journal of biological chemistry 2000;275(29):21953-9.
2000: K Kim; Keykavous Parang; OD Lau; Philip A Cole
Tyrosine analogues as alternative substrates for protein tyrosine kinase Csk: insights into substrate selectivity and catalytic mechanism.
Bioorganic & medicinal chemistry 2000;8(6):1263-8.
2000: OD Lau; T K Kundu; R E Soccio; SLIMANE AIT-SI-ALI; E M Khalil; A Vassilev; A P Wolffe; Y Nakatani; R G Roeder; Philip A Cole
HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.
Molecular cell 2000;5(3):589-95.
1999: Ehab M Khalil; Jacqueline De Angelis; M Ishii; Philip A Cole
Mechanism-based inhibition of the melatonin rhythm enzyme: pharmacologic exploitation of active site functional plasticity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(22):12418-23.
1999: D Sondhi; Philip A Cole
Domain interactions in protein tyrosine kinase Csk.
Biochemistry 1999;38(34):11147-55.
1999: Philip A Cole; D Sondhi; K Kim
Chemical approaches to the study of protein tyrosine kinases and their implications for mechanism and inhibitor design.
Pharmacology & therapeutics 1999;82(2-3):219-29.
1999: K Kim; Philip A Cole
Synthesis of (2S,3R)-beta-methyltyrosine catalyzed by tyrosine phenol-lyase.
Bioorganic & medicinal chemistry letters 1999;9(8):1205-8.
1998: Ehab M Khalil; Jacqueline De Angelis; Philip A Cole
Indoleamine analogs as probes of the substrate selectivity and catalytic mechanism of serotonin N-acetyltransferase.
The Journal of biological chemistry 1998;273(46):30321-7.
1998: Tom W Muir; D Sondhi; Philip A Cole
Expressed protein ligation: a general method for protein engineering.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6705-10.
1998: Jacqueline De Angelis; JA Gastel; David Klein; Philip A Cole
Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC 2.3.1.87).
The Journal of biological chemistry 1998;273(5):3045-50.
1998: D Sondhi; W Xu; Zhou Songyang; Michael J Eck; Philip A Cole
Peptide and protein phosphorylation by protein tyrosine kinase Csk: insights into specificity and mechanism.
Biochemistry 1998;37(1):165-72.
1997: M R Grace; C T Walsh; Philip A Cole
Divalent ion effects and insights into the catalytic mechanism of protein tyrosine kinase Csk.
Biochemistry 1997;36(7):1874-81.
1996: Philip A Cole
Chaperone-assisted protein expression.
Structure (London, England : 1993) 1996;4(3):239-42.
1995: Philip A Cole; M R Grace; Robert S Phillips; P Burn; Christopher T Walsh
The role of the catalytic base in the protein tyrosine kinase Csk.
The Journal of biological chemistry 1995;270(38):22105-8.
1994: Philip A Cole; P Burn; B Takacs; Christopher T Walsh
Evaluation of the catalytic mechanism of recombinant human Csk (C-terminal Src kinase) using nucleotide analogs and viscosity effects.
The Journal of biological chemistry 1994;269(49):30880-7.
1990: Philip A Cole; C H Robinson
Mechanism and inhibition of cytochrome P-450 aromatase.
Journal of medicinal chemistry 1990;33(11):2933-42.
1990: Philip A Cole; C H Robinson
Conversion of 19-oxo[2 beta-2H]androgens into oestrogens by human placental aromatase. An unexpected stereochemical outcome.
The Biochemical journal 1990;268(3):553-61.
1990: Philip A Cole; J M Bean; C H Robinson
Conversion of a 3-desoxysteroid to 3-desoxyestrogen by human placental aromatase.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):2999-3003.