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John Collinge

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Andrew G B Thompson; A Sarah Walker; Marie-Claire Porter; Peter Rudge; John Collinge; Liz Ford; Zoe Fox; Gosala S Gopalakrishnan; Michele Gorham; Jessica Lowe; Ana Lukic; Simon Mead
The Medical Research Council prion disease rating scale: a new outcome measure for prion disease therapeutic trials developed and validated using systematic observational studies.
Jon Beck; Aaron Borg; Jeremy Brown; Tracy Campbell; John Collinge; Nick C Fox; Pietro Fratta; John Hardy; Davina Hensman; John Hodges; Henry Houlden; Adrian M Isaacs; Colin J Mahoney; Andrea Malaspina; Richard W Orrell; James M Polke; Mark Poulter; Jonathan D Rohrer; Martin N Rossor; James Rowe; Jonathan M Schott; Katie Sidle; Sarah J Tabrizi; James Uphill; Jason D Warren; Gary Adamson; Simon Mead
Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population.
Rita Guerreiro; John Hardy; Lilinaz Hazrati; John S K Kauwe; Jean-Charles Lambert; Tammaryn Lashley; Elisa Majounie; Kevin Morgan; Jennifer Pocock; John Powell; Rosa Rademakers; Ekaterina Rogaeva; Celeste Sassi; Andrew Singleton; Peter St George-Hyslop; Julie Williams; Aleksandra Wojtas; Steven Younkin; Philippe Amouyel; Jose Bras; Minerva Carrasquillo; John Collinge; Carlos Cruchaga; Alison Goate
TREM2 variants in Alzheimer's disease.

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2013: Andrew G B Thompson; A Sarah Walker; Marie-Claire Porter; Peter Rudge; John Collinge; Liz Ford; Zoe Fox; Gosala S Gopalakrishnan; Michele Gorham; Jessica Lowe; Ana Lukic; Simon Mead
The Medical Research Council prion disease rating scale: a new outcome measure for prion disease therapeutic trials developed and validated using systematic observational studies.
Brain : a journal of neurology 2013;136(Pt 4):1116-27.
2013: Jon Beck; Aaron Borg; Jeremy Brown; Tracy Campbell; John Collinge; Nick C Fox; Pietro Fratta; John Hardy; Davina Hensman; John Hodges; Henry Houlden; Adrian M Isaacs; Colin J Mahoney; Andrea Malaspina; Richard W Orrell; James M Polke; Mark Poulter; Jonathan D Rohrer; Martin N Rossor; James Rowe; Jonathan M Schott; Katie Sidle; Sarah J Tabrizi; James Uphill; Jason D Warren; Gary Adamson; Simon Mead
Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population.
American journal of human genetics 2013;92(3):345-53.
2013: Rita Guerreiro; John Hardy; Lilinaz Hazrati; John S K Kauwe; Jean-Charles Lambert; Tammaryn Lashley; Elisa Majounie; Kevin Morgan; Jennifer Pocock; John Powell; Rosa Rademakers; Ekaterina Rogaeva; Celeste Sassi; Andrew Singleton; Peter St George-Hyslop; Julie Williams; Aleksandra Wojtas; Steven Younkin; Philippe Amouyel; Jose Bras; Minerva Carrasquillo; John Collinge; Carlos Cruchaga; Alison Goate
TREM2 variants in Alzheimer's disease.
The New England journal of medicine 2013;368(2):117-27.
2013: Shaheen Akhtar; Sebastian Brandner; John Collinge; Mar Fernandez de Marco; Julia Grizenkova; Holger Hummerich; Adam Wenborn; Sarah E Lloyd
Sod1 deficiency reduces incubation time in mouse models of prion disease.
PloS one 2013;8(1):e54454.
2012: Julia Grizenkova; Holger Hummerich; Shaheen Akhtar; Emmanuel A Asante; Sebastian Brandner; John Collinge; Elizabeth M C Fisher; Jérémie Fizet; Mark Poulter; Andrew Tomlinson; Victor L J Tybulewicz; Adam Wenborn; Frances K Wiseman; Sarah E Lloyd
Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(34):13722-7.
2012: Shabnam Ghazi-Noori; Emmanuel A Asante; Sebastian Brandner; John Collinge; Michael Farmer; Mar Fernandez de Marco; Elizabeth M C Fisher; Kristina E Froud; Sarah Mizielinska; Catherine O'Malley; Nick Parkinson; Caroline Powell; Michelle Smidak; Adrian M Isaacs
Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice.
Brain : a journal of neurology 2012;135(Pt 3):819-32.
2012: Colin J Mahoney; simon mead; Kin Mok; Tamas Revesz; Jonathan D Rohrer; Martin N Rossor; Jonathan M Schott; Tim Shakespeare; Jon Beck; John Collinge; Nick C Fox; John Hardy; Tammaryn Lashley; Elizabeth K Warrington; Tom Yeatman; Jason D Warren
Frontotemporal dementia with the C9ORF72 hexanucleotide repeat expansion: clinical, neuroanatomical and neuropathological features.
Brain : a journal of neurology 2012;135(Pt 3):736-50.
2012: Harpreet Hyare; Anil Ramlackhansingh; Peter Rudge; Sebastian Brandner; David J Brooks; John Collinge; Paul Edison; Giorgio Gelosa; Simon Mead
11C-PiB PET does not detect PrP-amyloid in prion disease patients including variant Creutzfeldt-Jakob disease.
Journal of neurology, neurosurgery, and psychiatry 2012;83(3):340-1.
2012: Rocio Castro-Seoane; John Collinge; Mar Fernandez de Marco; Holger Hummerich; Jacqueline M Linehan; Trevor Sweeting; M Howard Tattum; Sebastian Brandner; Peter-Christian Klöhn
Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection.
PLoS pathogens 2012;8(2):e1002538.
2012: Daniel McNaughton; John Collinge; Rita Guerreiro; John Hardy; William Knight; James Lowe; Jessica Lowe; David J Nicholl; Mark Poulter; Tamas Revesz; Martin Rossor; Natalie Ryan; Simon Mead
Duplication of amyloid precursor protein (APP), but not prion protein (PRNP) gene is a significant cause of early onset dementia in a large UK series.
Neurobiology of aging 2012;33(2):426.e13-21.
2012: Christopher Carswell; John Collinge; Ana Lukic; Simon Mead; Peter Rudge; John Stevens; Andrew Thompson; Harpreet Hyare
MRI findings are often missed in the diagnosis of Creutzfeldt-Jakob disease.
BMC neurology 2012;12():153.
2012: Christopher Carswell; John Collinge; Janet Darbyshire; Rebecca Macfarlane; Simon Mead; Suvankar Pal; Michael Rañopa; Durre Siddique; Dafydd Thomas; Sarah Walker; Tom Webb; Steve Wroe; Peter Rudge
Video Rating in Neurodegenerative Disease Clinical Trials: The Experience of PRION-1.
Dementia and geriatric cognitive disorders extra 2012;2(1):286-97.
2011: simon mead; M Ranopa; P Rudge; A G B Thompson; John Collinge; J H Darbyshire; G S Gopalakrishnan; F Hudson; A Kennedy; A MacKay; Stephen J Wroe; A S Walker
PRION-1 scales analysis supports use of functional outcome measures in prion disease.
Neurology 2011;77(18):1674-83.
2011: Pelagia Deriziotis; Michael H Glickman; Alfred L Goldberg; Rob Goold; Kerri J Kinghorn; Mark Kristiansen; Dasha Krutauz; James A Nathan; Rina Rosenzweig; David M Smith; Ralph André; John Collinge; Sarah J Tabrizi
Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry.
The EMBO journal 2011;30(15):3065-77.
2011: Diego N Kaski; Catherine Pennington; Jon Beck; Mark Poulter; James Uphill; Matthew T Bishop; Jaqueline M Linehan; Catherine O'Malley; Jonathan D F Wadsworth; Susan Joiner; Richard S G Knight; James W Ironside; Sebastian Brandner; John Collinge; simon mead
Inherited prion disease with 4-octapeptide repeat insertion: disease requires the interaction of multiple genetic risk factors.
Brain : a journal of neurology 2011;134(Pt 6):1829-38.
2011: Stéphanie Ratté; Martin Vreugdenhil; J K R Boult; A Patel; E A Asante; John Collinge; John Jefferys
Threshold for epileptiform activity is elevated in prion knockout mice.
Neuroscience 2011;179():56-61.
2011: Sara Rollinson; Jonathan D Rohrer; Julie van der Zee; Kristel Sleegers; Simon Mead; Sebastiaan Engelborghs; John Collinge; Peter P De Deyn; David M A Mann; Christine Van Broeckhoven; Stuart Pickering-Brown
No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration.
Neurobiology of aging 2011;32(4):754-5.
2011: Jonathan D F Wadsworth; Inmaculada Dalmau-Mena; Susan Joiner; Jacqueline M Linehan; Catherine O'Malley; Caroline Powell; Sebastian Brandner; Emmanuel A Asante; James W Ironside; David A Hilton; John Collinge
Effect of fixation on brain and lymphoreticular vCJD prions and bioassay of key positive specimens from a retrospective vCJD prevalence study.
The Journal of pathology 2011;223(4):511-8.
2011: Julie Ann Edgeworth; Anita Sicilia; Jackie Linehan; Sebastian Brandner; Graham S Jackson; John Collinge
A standardized comparison of commercially available prion decontamination reagents using the Standard Steel-Binding Assay.
The Journal of general virology 2011;92(Pt 3):718-26.
2011: Malin K Sandberg; Huda Al-Doujaily; Bernadette Sharps; Anthony R Clarke; John Collinge
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases.
Nature 2011;470(7335):540-2.
2011: Julie Ann Edgeworth; Michael Farmer; Anita Sicilia; Paul Tavares; Jonathan Beck; Tracy Campbell; Jessica Lowe; simon mead; Peter Rudge; John Collinge; Graham S Jackson
Detection of prion infection in variant Creutzfeldt-Jakob disease: a blood-based assay.
Lancet 2011;377(9764):487-93.
2011: Sarah Lloyd; Simon Mead; John Collinge
Genetics of prion disease.
Topics in current chemistry 2011;305():1-22.
2011: R Goold; S Rabbanian; L Sutton; R Andre; P Arora; J Moonga; Anthony R Clarke; Giampietro Schiavo; P Jat; John Collinge; Sarah J Tabrizi
Rapid cell-surface prion protein conversion revealed using a novel cell system.
Nature communications 2011;2():281.
2011: Jonathan D F Wadsworth; John Collinge
Molecular pathology of human prion disease.
Acta neuropathologica 2011;121(1):69-77.
2011: Lilla Reiniger; Ana Lukic; Jacqueline Linehan; Peter Rudge; John Collinge; Simon Mead; Sebastian Brandner
Tau, prions and Aβ: the triad of neurodegeneration.
Acta neuropathologica 2011;121(1):5-20.
2010: J D F Wadsworth; Emmanuel A Asante; John Collinge
Review: contribution of transgenic models to understanding human prion disease.
Neuropathology and applied neurobiology 2010;36(7):576-97.
2010: Durrenajaf Siddique; Harpreet Hyare; Stephen J Wroe; Thomas Webb; Rebecca Macfarlane; Peter Rudge; John Collinge; Caroline Powell; Sebastian Brandner; Po-Wah So; Sarah Walker; simon mead; Tarek A Yousry; John S Thornton
Magnetization transfer ratio may be a surrogate of spongiform change in human prion diseases.
Brain : a journal of neurology 2010;133(10):3058-68.
2010: Malin K Sandberg; Huda Al-Doujaily; Christina J Sigurdson; Markus Glatzel; Catherine O'Malley; Caroline Powell; Emmanuel A Asante; Jacqueline M Linehan; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein.
The Journal of general virology 2010;91(Pt 10):2651-7.
2010: Julie A Edgeworth; Nathalie Gros; Jack Alden; Susan Joiner; Jonathan D F Wadsworth; Jackie Linehan; Sebastian Brandner; Graham S Jackson; Charles Weissmann; John Collinge
Spontaneous generation of mammalian prions.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(32):14402-6.
2010: Jon A Beck; Mark Poulter; Tracy A Campbell; Gary Adamson; James B Uphill; Rita Guerreiro; Graham S Jackson; James C Stevens; Hadi Manji; John Collinge; simon mead
PRNP allelic series from 19 years of prion protein gene sequencing at the MRC Prion Unit.
Human mutation 2010;31(7):E1551-63.
2010: John Collinge
Medicine. Prion strain mutation and selection.
Science (New York, N.Y.) 2010;328(5982):1111-2.
2010: Sarah E Lloyd; Emma G Maytham; Julia Grizenkova; Holger Hummerich; John Collinge
A Copine family member, Cpne8, is a candidate quantitative trait gene for prion disease incubation time in mouse.
Neurogenetics 2010;11(2):185-91.
2010: Harpreet Hyare; Stephen J Wroe; D Siddique; T Webb; Nick C Fox; J Stevens; John Collinge; Tarek A Yousry; J S Thornton
Brain-water diffusion coefficients reflect the severity of inherited prion disease.
Neurology 2010;74(8):658-65.
2010: Laura D'Castro; Adam Wenborn; Nathalie Gros; Susan Joiner; Sabrina Cronier; John Collinge; Jonathan D F Wadsworth
Isolation of proteinase K-sensitive prions using pronase E and phosphotungstic acid.
PloS one 2010;5(12):e15679.
2010: Julia Grizenkova; Shaheen Akhtar; John Collinge; Sarah E Lloyd
The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.
PloS one 2010;5(12):e15019.
2010: Ruth Chia; M Howard Tattum; Samantha Jones; John Collinge; Elizabeth M C Fisher; Graham S Jackson
Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis.
PloS one 2010;5(5):e10627.
2009: Diego Kaski; Simon Mead; Harpreet Hyare; Sarah Cooper; Ravi Jampana; James Overell; Richard Knight; John Collinge; Peter Rudge
Variant CJD in an individual heterozygous for PRNP codon 129.
Lancet 2009;374(9707):2128.
2009: Simon Mead; Jerome Whitfield; Mark Poulter; Paresh Shah; James Uphill; Tracy Campbell; Huda Al-Dujaily; Holger Hummerich; Jon Beck; Charles A Mein; Claudio Verzilli; John Whittaker; Michael P Alpers; John Collinge
A novel protective prion protein variant that colocalizes with kuru exposure.
The New England journal of medicine 2009;361(21):2056-65.
2009: Laszlo L P Hosszu; Clare R Trevitt; Samantha Jones; Mark Batchelor; David J Scott; Graham S Jackson; John Collinge; Jonathan P Waltho; Anthony R Clarke
Conformational properties of beta-PrP.
The Journal of biological chemistry 2009;284(33):21981-90.
2009: T Webb; simon mead; Jon Beck; J Uphill; S Pal; S Hampson; J D F Wadsworth; I Dalmau Mena; C O'Malley; Stephen J Wroe; A Schapira; Sebastian Brandner; John Collinge
Seven-year discordance in age at onset in monozygotic twins with inherited prion disease (P102L).
Neuropathology and applied neurobiology 2009;35(4):427-32.
2009: T E F Webb; J Whittaker; John Collinge; simon mead
Age of onset and death in inherited prion disease are heritable.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2009;150B(4):496-501.
2009: Sarah E Lloyd; Julia Grizenkova; Hirva Pota; John Collinge
Shadoo (Sprn) and prion disease incubation time in mice.
Mammalian genome : official journal of the International Mammalian Genome Society 2009;20(6):367-74.
2009: Tanya Hart; Laszlo L P Hosszu; Clare R Trevitt; Graham S Jackson; Jonathan P Waltho; John Collinge; Anthony R Clarke
Folding kinetics of the human prion protein probed by temperature jump.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5651-6.
2009: John Collinge; Michele Gorham; Fleur Hudson; Angus Kennedy; Geraldine Keogh; Suvankar Pal; Martin N Rossor; Peter Rudge; Durre Siddique; Moira Spyer; Dafydd Thomas; Sarah Walker; Tom Webb; Stephen J Wroe; Janet Darbyshire
Safety and efficacy of quinacrine in human prion disease (PRION-1 study): a patient-preference trial.
Lancet neurology 2009;8(4):334-44.
2009: Sara Rollinson; Patrizia Rizzu; Stephen Sikkink; Matthew Baker; Nicola Halliwell; Julie Snowden; Bryan Joseph Traynor; Dina Ruano; Nigel J Cairns; Jonathan D Rohrer; Simon Mead; John Collinge; Martin N Rossor; Ela Akay; Rita Guerreiro; Rosa Rademakers; Karen E Morrison; Pau Pastor; Elena Alonso; Pablo Martinez-Lage; Neil Graff-Radford; David Neary; Peter Heutink; D M A Mann; John Van Swieten; Stuart Pickering-Brown
Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration.
Neurobiology of aging 2009;30(4):656-65.
2009: Julie Ann Edgeworth; Graham S Jackson; Anthony R Clarke; Charles Weissmann; John Collinge
Highly sensitive, quantitative cell-based assay for prions adsorbed to solid surfaces.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(9):3479-83.
2009: MOURAD TAYEBI; John Collinge; Simon Hawke
Unswitched immunoglobulin M response prolongs mouse survival in prion disease.
The Journal of general virology 2009;90(Pt 3):777-82.
2009: Emmanuel A Asante; Ian Gowland; Andrew Grimshaw; Jacqueline M Linehan; Michelle Smidak; Richard Houghton; Olufunmilayo Osiguwa; Andrew Tomlinson; Susan Joiner; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
Absence of spontaneous disease and comparative prion susceptibility of transgenic mice expressing mutant human prion proteins.
The Journal of general virology 2009;90(Pt 3):546-58.
2009: Sarah E Lloyd; Emma G Maytham; Hirva Pota; Julia Grizenkova; Eleni Molou; James Uphill; Holger Hummerich; Jerome Whitfield; Michael P Alpers; Simon Mead; John Collinge
HECTD2 is associated with susceptibility to mouse and human prion disease.
PLoS genetics 2009;5(2):e1000383.
2009: Andrew J Nicoll; John Collinge
Preventing prion pathogenicity by targeting the cellular prion protein.
Infectious disorders drug targets 2009;9(1):48-57.
2009: Sarah E Lloyd; Martin N Rossor; Nick C Fox; Simon Mead; John Collinge
HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q.
BMC medical genetics 2009;10():90.
2008: Jonathan A Beck; Tracy A Campbell; G Adamson; Mark Poulter; James B Uphill; E Molou; John Collinge; simon mead
Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease.
Journal of medical genetics 2008;45(12):813-7.
2008: Sabrina Cronier; Nathalie Gros; M Howard Tattum; Graham S Jackson; Anthony R Clarke; John Collinge; Jonathan D F Wadsworth
Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin.
The Biochemical journal 2008;416(2):297-305.
2008: simon mead; Mark Poulter; John Beck; James Uphill; Chris Jones; Cheng Eng Ang; Charles A Mein; John Collinge
Successful amplification of degraded DNA for use with high-throughput SNP genotyping platforms.
Human mutation 2008;29(12):1452-8.
2008: Sebastian Brandner; Jerome Whitfield; Ken Boone; Anderson Puwa; Catherine O'Malley; Jacqueline M Linehan; Susan Joiner; Francesco Scaravilli; Ian Calder; Michael P Alpers; Jonathan D F Wadsworth; John Collinge
Central and peripheral pathology of kuru: pathological analysis of a recent case and comparison with other forms of human prion disease.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1510):3755-63.
2008: Jonathan D F Wadsworth; Susan Joiner; Jacqueline M Linehan; Emmanuel A Asante; Sebastian Brandner; John Collinge
Review. The origin of the prion agent of kuru: molecular and biological strain typing.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1510):3747-53.
2008: simon mead; Jerome Whitfield; Mark Poulter; Paresh Shah; James Uphill; Jonathan Beck; Tracy Campbell; Huda Al-Dujaily; Holger Hummerich; Michael P Alpers; John Collinge
Genetic susceptibility, evolution and the kuru epidemic.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1510):3741-6.
2008: John Collinge; Jerome Whitfield; Edward McKintosh; Adam Frosh; simon mead; Andrew Hill; Sebastian Brandner; Dafydd Thomas; Michael P Alpers
A clinical study of kuru patients with long incubation periods at the end of the epidemic in Papua New Guinea.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1510):3725-39.
2008: Jerome T Whitfield; Wandagi H Pako; John Collinge; Michael P Alpers
Mortuary rites of the South Fore and kuru.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1510):3721-4.
2008: John Collinge
Review. Lessons of kuru research: background to recent studies with some personal reflections.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1510):3689-96.
2008: John Collinge; Michael P Alpers
Reminiscences and reflections on kuru, personal and scientific.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1510):3613.
2008: John Collinge; Michael P Alpers
Introduction.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2008;363(1510):3607-12.
2008: Stéphanie Ratté; Steven A Prescott; John Collinge; John Jefferys
Hippocampal bursts caused by changes in NMDA receptor-dependent excitation in a mouse model of variant CJD.
Neurobiology of disease 2008;32(1):96-104.
2008: Thomas E F Webb; Suvankar Pal; Durrenajaf Siddique; Dominic C Heaney; Jacqueline M Linehan; Jonathan D F Wadsworth; Susan Joiner; Jon Beck; Stephen J Wroe; Valerie Stevenson; Sebastian Brandner; simon mead; John Collinge
First report of Creutzfeldt-Jakob disease occurring in 2 siblings unexplained by PRNP mutation.
Journal of neuropathology and experimental neurology 2008;67(9):838-41.
2008: Marie O'Shea; Emma G Maytham; Jacqueline M Linehan; Sebastian Brandner; John Collinge; Sarah E Lloyd
Investigation of mcp1 as a quantitative trait gene for prion disease incubation time in mouse.
Genetics 2008;180(1):559-66.
2008: Jonathan D Rohrer; Jason D Warren; Josephine Barnes; simon mead; Jonathan Beck; Tracey Pepple; Richard Boyes; Rohani Omar; John Collinge; John M Stevens; Elizabeth K Warrington; Martin N Rossor; Nick C Fox
Mapping the progression of progranulin-associated frontotemporal lobar degeneration.
Nature clinical practice. Neurology 2008;4(8):455-60.
2008: Melanie D White; Michael Farmer; Ilaria Mirabile; Sebastian Brandner; John Collinge; Giovanna R Mallucci
Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(29):10238-43.
2008: Andrew D Powell; Emil Toescu; John Collinge; John Jefferys
Alterations in Ca2+-buffering in prion-null mice: association with reduced afterhyperpolarizations in CA1 hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(15):3877-86.
2008: Jonathan D Rohrer; Jason D Warren; Rohani Omar; simon mead; Jonathan Beck; Tamas Revesz; Janice Holton; John M Stevens; Safa Al-Sarraj; Stuart M Pickering-Brown; John Hardy; Nick C Fox; John Collinge; Elizabeth K Warrington; Martin N Rossor
Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene.
Archives of neurology 2008;65(4):506-13.
2008: Jonathan D F Wadsworth; Susan Joiner; Jacqueline M Linehan; Melanie Desbruslais; Katie Fox; Sharon Cooper; Sabrina Cronier; Emmanuel A Asante; simon mead; Sebastian Brandner; Andrew Hill; John Collinge
Kuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3885-90.
2008: Jonathan Beck; Jonathan D Rohrer; Tracy Campbell; Adrian Isaacs; Karen E Morrison; Emily F Goodall; Elizabeth K Warrington; John Stevens; Tamas Revesz; Janice Holton; Safa Al-Sarraj; Andrew King; Rachael I Scahill; Jason D Warren; Nick C Fox; Martin N Rossor; John Collinge; simon mead
A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series.
Brain : a journal of neurology 2008;131(Pt 3):706-20.
2008: Jonathan D F Wadsworth; Caroline Powell; Jonathan A Beck; Susan Joiner; Jacqueline M Linehan; Sebastian Brandner; simon mead; John Collinge
Molecular diagnosis of human prion disease.
Methods in molecular biology (Clifton, N.J.) 2008;459():197-227.
2007: simon mead; Susan Joiner; Melanie Desbruslais; Jonathan A Beck; Michael O'Donoghue; Peter Lantos; Jonathan D F Wadsworth; John Collinge
Creutzfeldt-Jakob disease, prion protein gene codon 129VV, and a novel PrPSc type in a young British woman.
Archives of neurology 2007;64(12):1780-4.
2007: John Collinge; Anthony R Clarke
A general model of prion strains and their pathogenicity.
Science (New York, N.Y.) 2007;318(5852):930-6.
2007: Azadeh Khalili-Shirazi; Maria Kaisar; Gary Mallinson; Samantha Jones; Daljit Bhelt; Carol Fraser; Anthony R Clarke; Simon Hawke; Graham S Jackson; John Collinge
Beta-PrP form of human prion protein stimulates production of monoclonal antibodies to epitope 91-110 that recognise native PrPSc.
Biochimica et biophysica acta 2007;1774(11):1438-50.
2007: simon mead; Thomas E F Webb; Tracy A Campbell; Jon Beck; Jacqueline M Linehan; S Rutherfoord; Susan Joiner; Jonathan D F Wadsworth; J Heckmann; Stephen J Wroe; LJ Doey; Andrew King; John Collinge
Inherited prion disease with 5-OPRI: phenotype modification by repeat length and codon 129.
Neurology 2007;69(8):730-8.
2007: William D Knight; J Kennedy; simon mead; Martin N Rossor; Jon Beck; John Collinge; C Mummery
A novel presenilin 1 deletion (p.L166del) associated with early onset familial Alzheimer's disease.
European journal of neurology : the official journal of the European Federation of Neurological Societies 2007;14(7):829-31.
2007: R G Macfarlane; Stephen J Wroe; John Collinge; Tarek A Yousry; H Rolf Jäger
Neuroimaging findings in human prion disease.
Journal of neurology, neurosurgery, and psychiatry 2007;78(7):664-70.
2007: Jonathan D F Wadsworth; John Collinge
Update on human prion disease.
Biochimica et biophysica acta 2007;1772(6):598-609.
2007: Mark Kristiansen; Pelagia Deriziotis; Derek E Dimcheff; Graham S Jackson; Huib Ovaa; Heike Naumann; Anthony R Clarke; Fijs W B van Leeuwen; Victoria Menéndez-Benito; Nico P Dantuma; John L Portis; John Collinge; Sarah J Tabrizi
Disease-associated prion protein oligomers inhibit the 26S proteasome.
Molecular cell 2007;26(2):175-88.
2007: Giovanna Mallucci; Melanie D White; Michael Farmer; Andrew Dickinson; Husna Khatun; Andrew D Powell; Sebastian Brandner; John Jefferys; John Collinge
Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice.
Neuron 2007;53(3):325-35.
2007: Lisa A Stone; Graham S Jackson; John Collinge; Jonathan D F Wadsworth; Anthony R Clarke
Inhibition of proteinase K activity by copper(II) ions.
Biochemistry 2007;46(1):245-52.
2007: Jonathan D F Wadsworth; Susan Joiner; K Fox; Jacqueline M Linehan; Melanie Desbruslais; Sebastian Brandner; Emmanuel A Asante; John Collinge
Prion infectivity in variant Creutzfeldt-Jakob disease rectum.
Gut 2007;56(1):90-4.
2006: Mark A Wells; Clare Jelinska; Laszlo L P Hosszu; C Jeremy Craven; Anthony R Clarke; John Collinge; Jonathan P Waltho; Graham S Jackson
Multiple forms of copper (II) co-ordination occur throughout the disordered N-terminal region of the prion protein at pH 7.4.
The Biochemical journal 2006;400(3):501-10.
2006: Stephen J Wroe; Suvankar Pal; Durrenajaf Siddique; Harpreet Hyare; Rebecca Macfarlane; Susan Joiner; Jacqueline M Linehan; Sebastian Brandner; Jonathan D F Wadsworth; Patricia Hewitt; John Collinge
Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report.
Lancet 2006;368(9552):2061-7.
2006: Jonathan D Rohrer; simon mead; Rohani Omar; Mark Poulter; Jason D Warren; John Collinge; Martin N Rossor
Prion protein (PRNP) genotypes in frontotemporal lobar degeneration syndromes.
Annals of neurology 2006;60(5):616; author reply 617.
2006: Mark A Wells; Graham S Jackson; Samantha Jones; Laszlo L P Hosszu; C Jeremy Craven; Anthony R Clarke; John Collinge; Jonathan P Waltho
A reassessment of copper(II) binding in the full-length prion protein.
The Biochemical journal 2006;399(3):435-44.
2006: N Parkinson; Paul Geoffrey Ince; M O Smith; R Highley; Gaia Skibinski; Peter M Andersen; Karen E Morrison; H S Pall; Orla Hardiman; John Collinge; Pamela J Shaw; Elizabeth M C Fisher
ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B).
Neurology 2006;67(6):1074-7.
2006: simon mead; Mark Poulter; Jon Beck; Thomas E F Webb; Tracy A Campbell; Jacqueline M Linehan; Melanie Desbruslais; Susan Joiner; Jonathan D F Wadsworth; Andrew King; Peter Lantos; John Collinge
Inherited prion disease with six octapeptide repeat insertional mutation--molecular analysis of phenotypic heterogeneity.
Brain : a journal of neurology 2006;129(Pt 9):2297-317.
2006: Clare R Trevitt; John Collinge
A systematic review of prion therapeutics in experimental models.
Brain : a journal of neurology 2006;129(Pt 9):2241-65.
2006: Patrick A Lewis; M Howard Tattum; Samantha Jones; Daljit Bhelt; Mark Batchelor; Anthony R Clarke; John Collinge; Graham S Jackson
Codon 129 polymorphism of the human prion protein influences the kinetics of amyloid formation.
The Journal of general virology 2006;87(Pt 8):2443-9.
2006: Emmanuel A Asante; Jacqueline M Linehan; Ian Gowland; Susan Joiner; Katie Fox; Sharon Cooper; Olufumilayo Osiguwa; Michelle Gorry; Julie Welch; Richard Houghton; Melanie Desbruslais; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
Dissociation of pathological and molecular phenotype of variant Creutzfeldt-Jakob disease in transgenic human prion protein 129 heterozygous mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(28):10759-64.
2006: John Collinge; Jerome Whitfield; Edward McKintosh; Jon Beck; simon mead; Dafydd J Thomas; Michael P Alpers
Kuru in the 21st century--an acquired human prion disease with very long incubation periods.
Lancet 2006;367(9528):2068-74.
2006: Adam D Waldman; Rebecca Cordery; David G MacManus; Alison K Godbolt; John Collinge; Martin N Rossor
Regional brain metabolite abnormalities in inherited prion disease and asymptomatic gene carriers demonstrated in vivo by quantitative proton magnetic resonance spectroscopy.
Neuroradiology 2006;48(6):428-33.
2006: Jonathan D F Wadsworth; Susan Joiner; Jacqueline M Linehan; Sharon Cooper; Caroline Powell; Gary Mallinson; Jennifer Buckell; Ian Gowland; Emmanuel A Asante; Herbert Budka; Sebastian Brandner; John Collinge
Phenotypic heterogeneity in inherited prion disease (P102L) is associated with differential propagation of protease-resistant wild-type and mutant prion protein.
Brain : a journal of neurology 2006;129(Pt 6):1557-69.
2006: Patrick A Lewis; Francesca Properzi; Kanella Prodromidou; Anthony R Clarke; John Collinge; Graham S Jackson
Removal of the glycosylphosphatidylinositol anchor from PrP(Sc) by cathepsin D does not reduce prion infectivity.
The Biochemical journal 2006;395(2):443-8.
2006: M Howard Tattum; Sara Cohen-Krausz; Kanjana Thumanu; Christopher W Wharton; Azadeh Khalili-Shirazi; Graham S Jackson; Elena V Orlova; John Collinge; Anthony R Clarke; Helen R Saibil
Elongated oligomers assemble into mammalian PrP amyloid fibrils.
Journal of molecular biology 2006;357(3):975-85.
2006: Andrew Hill; Susan Joiner; Jonathan A Beck; Tracy A Campbell; Andrew Dickinson; Mark Poulter; Jonathan D F Wadsworth; John Collinge
Distinct glycoform ratios of protease resistant prion protein associated with PRNP point mutations.
Brain : a journal of neurology 2006;129(Pt 3):676-85.
2006: Alison K Godbolt; Jonathan A Beck; John Collinge; Lisa Cipolotti; Nick C Fox; Martin N Rossor
A second family with familial AD and the V717L APP mutation has a later age at onset.
Neurology 2006;66(4):611-2.
2005: Laszlo L P Hosszu; Mark A Wells; Graham S Jackson; Samantha Jones; Mark Batchelor; Anthony R Clarke; C Jeremy Craven; Jonathan P Waltho; John Collinge
Definable equilibrium states in the folding of human prion protein.
Biochemistry 2005;44(50):16649-57.
2005: Samantha Jones; Mark Batchelor; Daljit Bhelt; Anthony R Clarke; John Collinge; Graham S Jackson
Recombinant prion protein does not possess SOD-1 activity.
The Biochemical journal 2005;392(Pt 2):309-12.
2005: Mark Kristiansen; Marcus J Messenger; Peter-Christian Klöhn; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge; Sarah J Tabrizi
Disease-related prion protein forms aggresomes in neuronal cells leading to caspase activation and apoptosis.
The Journal of biological chemistry 2005;280(46):38851-61.
2005: Susan Joiner; Jacqueline M Linehan; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
High levels of disease related prion protein in the ileum in variant Creutzfeldt-Jakob disease.
Gut 2005;54(10):1506-8.
2005: Azadeh Khalili-Shirazi; Linda Summers; Jacqueline M Linehan; Gary Mallinson; David J Anstee; Simon Hawke; Graham S Jackson; John Collinge
PrP glycoforms are associated in a strain-specific ratio in native PrPSc.
The Journal of general virology 2005;86(Pt 9):2635-44.
2005: Gaia Skibinski; Nicholas J Parkinson; Jeremy M Brown; Lisa Chakrabarti; Sarah L Lloyd; Holger Hummerich; Jørgen E Nielsen; John R Hodges; Maria Grazia Spillantini; Tove Thusgaard; Sebastian Brandner; Arne Brun; Martin N Rossor; Anders Gade; Peter Johannsen; Sven Asger Sørensen; Susanne Gydesen; Elizabeth M C Fisher; John Collinge
Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia.
Nature genetics 2005;37(8):806-8.
2005: John Collinge
Molecular neurology of prion disease.
Journal of neurology, neurosurgery, and psychiatry 2005;76(7):906-19.
2005: Azadeh Khalili-Shirazi; Sonia Quaratino; Marco Londei; Linda Summers; MOURAD TAYEBI; Anthony R Clarke; Simon Hawke; Graham S Jackson; John Collinge
Protein conformation significantly influences immune responses to prion protein.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(6):3256-63.
2005: Graham S Jackson; Edward McKintosh; Eckhard Flechsig; Kanella Prodromidou; Petra Hirsch; Jacqueline M Linehan; Sebastian Brandner; Anthony R Clarke; Charles Weissmann; John Collinge
An enzyme-detergent method for effective prion decontamination of surgical steel.
The Journal of general virology 2005;86(Pt 3):869-78.
2005: Rebecca Cordery; K Alner; Lisa Cipolotti; M Ron; A Kennedy; John Collinge; Martin N Rossor
The neuropsychology of variant CJD: a comparative study with inherited and sporadic forms of prion disease.
Journal of neurology, neurosurgery, and psychiatry 2005;76(3):330-6.
2005: Majid Hafezparast; Sebastian Brandner; Jacqueline M Linehan; Joanne E Martin; John Collinge; Elizabeth M C Fisher
Prion disease incubation time is not affected in mice heterozygous for a dynein mutation.
Biochemical and biophysical research communications 2005;326(1):18-22.
2005: Giovanna Mallucci; John Collinge
Rational targeting for prion therapeutics.
Nature reviews. Neuroscience 2005;6(1):23-34.
2004: Jonathan D F Wadsworth; Emmanuel A Asante; Melanie Desbruslais; Jacqueline M Linehan; Susan Joiner; Ian Gowland; Julie Welch; Lisa Stone; Sarah E Lloyd; Andrew Hill; Sebastian Brandner; John Collinge
Human prion protein with valine 129 prevents expression of variant CJD phenotype.
Science (New York, N.Y.) 2004;306(5702):1793-6.
2004: Giovanna Mallucci; John Collinge
Update on Creutzfeldt-Jakob disease.
Current opinion in neurology 2004;17(6):641-7.
2004: Alison K Godbolt; Jonathan A Beck; John Collinge; P Garrard; Jason D Warren; Nick C Fox; Martin N Rossor
A presenilin 1 R278I mutation presenting with language impairment.
Neurology 2004;63(9):1702-4.
2004: Adam Frosh; Lorraine C Smith; Carl J Jackson; Jacqueline M Linehan; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
Analysis of 2000 consecutive UK tonsillectomy specimens for disease-related prion protein.
Lancet 2004;364(9441):1260-2.
2004: Vincent Beringue; Didier Vilette; Gary Mallinson; Fabienne Archer; Maria Kaisar; MOURAD TAYEBI; Graham S Jackson; Anthony R Clarke; Hubert Laude; John Collinge; Simon Hawke
PrPSc binding antibodies are potent inhibitors of prion replication in cell lines.
The Journal of biological chemistry 2004;279(38):39671-6.
2004: Sarah E Lloyd; Jacqueline M Linehan; Melanie Desbruslais; Susan Joiner; Jennifer Buckell; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
Characterization of two distinct prion strains derived from bovine spongiform encephalopathy transmissions to inbred mice.
The Journal of general virology 2004;85(Pt 8):2471-8.
2004: Laszlo L P Hosszu; Graham S Jackson; Clare R Trevitt; Samantha Jones; Mark Batchelor; Daljit Bhelt; Kanella Prodromidou; Anthony R Clarke; Jonathan P Waltho; John Collinge
The residue 129 polymorphism in human prion protein does not confer susceptibility to Creutzfeldt-Jakob disease by altering the structure or global stability of PrPC.
The Journal of biological chemistry 2004;279(27):28515-21.
2004: MOURAD TAYEBI; Perry Enever; Zahid Sattar; John Collinge; Simon Hawke
Disease-associated prion protein elicits immunoglobulin M responses in vivo.
Molecular medicine (Cambridge, Mass.) 2004;10(7-12):104-11.
2004: Jonathan A Beck; Mark Poulter; Tracy A Campbell; James B Uphill; Gary Adamson; Jennian F Geddes; Tamas Revesz; Mary B Davis; Nicholas W Wood; John Collinge; Sarah J Tabrizi
Somatic and germline mosaicism in sporadic early-onset Alzheimer's disease.
Human molecular genetics 2004;13(12):1219-24.
2004: Sarah E Lloyd; Simon R Thompson; Jonathan A Beck; Jacqueline M Linehan; Jonathan D F Wadsworth; Sebastian Brandner; John Collinge; Elizabeth M C Fisher
Identification and characterization of a novel mouse prion gene allele.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(5):383-9.
2004: Emmanuel A Asante; Yuan-Gen Li; Ian Gowland; John Jefferys; John Collinge
Pathogenic human prion protein rescues PrP null phenotype in transgenic mice.
Neuroscience letters 2004;360(1-2):33-6.
2004: Jerry Brown; Susanne Gydesen; Peter Johannsen; Anders Gade; Gaia Skibinski; Lisa Chakrabarti; Arne Brun; Maria Grazia Spillantini; Despina Yancopoulou; Tove Thusgaard; Asger Sorensen; Elizabeth Fisher; John Collinge
Frontotemporal dementia linked to chromosome 3.
Dementia and geriatric cognitive disorders 2004;17(4):274-6.
2004: Andrew Hill; John Collinge
Prion strains and species barriers.
Contributions to microbiology 2004;11():33-49.
2003: Giovanna Mallucci; Andrew Dickinson; Jacqueline M Linehan; Peter-Christian Klöhn; Sebastian Brandner; John Collinge
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis.
Science (New York, N.Y.) 2003;302(5646):871-4.
2003: Vincent Beringue; Gary Mallinson; Maria Kaisar; MOURAD TAYEBI; Zahid Sattar; Graham Jackson; David J Anstee; John Collinge; Simon Hawke
Regional heterogeneity of cellular prion protein isoforms in the mouse brain.
Brain : a journal of neurology 2003;126(Pt 9):2065-73.
2003: Andrew Hill; Susan Joiner; Jonathan D F Wadsworth; Katie C L Sidle; Jeanne E Bell; Herbert Budka; James W Ironside; John Collinge
Molecular classification of sporadic Creutzfeldt-Jakob disease.
Brain : a journal of neurology 2003;126(Pt 6):1333-46.
2003: simon mead; Michael P H Stumpf; Jerome Whitfield; Jonathan A Beck; Mark Poulter; Tracy Campbell; James B Uphill; David Goldstein; Michael Alpers; Elizabeth M C Fisher; John Collinge
Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics.
Science (New York, N.Y.) 2003;300(5619):640-3.
2003: Edward McKintosh; Sarah J Tabrizi; John Collinge
Prion diseases.
Journal of neurovirology 2003;9(2):183-93.
2003: Andrew King; LJ Doey; Martin N Rossor; simon mead; John Collinge; Peter Lantos
Phenotypic variability in the brains of a family with a prion disease characterized by a 144-base pair insertion in the prion protein gene.
Neuropathology and applied neurobiology 2003;29(2):98-105.
2003: Anthony R White; Perry Enever; MOURAD TAYEBI; Rosey Mushens; Jacqueline M Linehan; Sebastian Brandner; David J Anstee; John Collinge; Simon Hawke
Monoclonal antibodies inhibit prion replication and delay the development of prion disease.
Nature 2003;422(6927):80-3.
2003: John C Janssen; Jonathan A Beck; Tracy A Campbell; Andrew Dickinson; Nick C Fox; Robert J Harvey; Henry Houlden; Martin N Rossor; John Collinge
Early onset familial Alzheimer's disease: Mutation frequency in 31 families.
Neurology 2003;60(2):235-9.
2003: Jonathan D F Wadsworth; Andrew Hill; Jonathan A Beck; John Collinge
Molecular and clinical classification of human prion disease.
British medical bulletin 2003;66():241-54.
2003: Andrew Hill; John Collinge
Subclinical prion infection in humans and animals.
British medical bulletin 2003;66():161-70.
2002: Emmanuel A Asante; Jacqueline M Linehan; Melanie Desbruslais; Susan Joiner; Ian Gowland; Andrew L Wood; Julie Welch; Andrew Hill; Sarah E Lloyd; Jonathan D F Wadsworth; John Collinge
BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein.
The EMBO journal 2002;21(23):6358-66.
2002: Eleni Makrinou; John Collinge; Michael Antoniou
Genomic characterization of the human prion protein (PrP) gene locus.
Mammalian genome : official journal of the International Mammalian Genome Society 2002;13(12):696-703.
2002: Susanne Gydesen; Jeremy M Brown; Arne Brun; Lisa Chakrabarti; Anders Gade; Peter Johannsen; Martin N Rossor; Tove Thusgaard; A Grove; Despina Yancopoulou; Maria Grazia Spillantini; Elizabeth M C Fisher; John Collinge; S A Sorensen
Chromosome 3 linked frontotemporal dementia (FTD-3).
Neurology 2002;59(10):1585-94.
2002: Susan Joiner; Jacqueline M Linehan; Sebastian Brandner; Jonathan D F Wadsworth; John Collinge
Irregular presence of abnormal prion protein in appendix in variant Creutzfeldt-Jakob disease.
Journal of neurology, neurosurgery, and psychiatry 2002;73(5):597-8.
2002: Sarah E Lloyd; James B Uphill; Paul V Targonski; Elizabeth M C Fisher; John Collinge
Identification of genetic loci affecting mouse-adapted bovine spongiform encephalopathy incubation time in mice.
Neurogenetics 2002;4(2):77-81.
2002: Emmanuel A Asante; Ian Gowland; Jacqueline M Linehan; SP Mahal; John Collinge
Expression pattern of a mini human PrP gene promoter in transgenic mice.
Neurobiology of disease 2002;10(1):1-7.
2002: Giovanna Mallucci; S Ratté; Emmanuel A Asante; Jacqueline M Linehan; Ian Gowland; John Jefferys; John Collinge
Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration.
The EMBO journal 2002;21(3):202-10.
2002: Andrew Hill; John Collinge
Species-barrier-independent prion replication in apparently resistant species.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2002;110(1):44-53.
2001: Graham S Jackson; John Collinge
The molecular pathology of CJD: old and new variants.
Molecular pathology : MP 2001;54(6):393-9.
2001: simon mead; SP Mahal; Jon Beck; T Campbell; Martin Farrall; E Fisher; John Collinge
Sporadic--but not variant--Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1.
American journal of human genetics 2001;69(6):1225-35.
2001: Graham S Jackson; Jonathan A Beck; C Navarrete; J Brown; P M Sutton; M Contreras; John Collinge
HLA-DQ7 antigen and resistance to variant CJD.
Nature 2001;414(6861):269-70.
2001: Eckhard Flechsig; Ivan Hegyi; Masato Enari; Petra Schwarz; John Collinge; Charles Weissmann
Transmission of scrapie by steel-surface-bound prions.
Molecular medicine (Cambridge, Mass.) 2001;7(10):679-84.
2001: Jonathan A Beck; simon mead; Tracy A Campbell; Andrew Dickinson; D P Wientjens; Esther A Croes; C.M. Duijn; John Collinge
Two-octapeptide repeat deletion of prion protein associated with rapidly progressive dementia.
Neurology 2001;57(2):354-6.
2001: Jonathan D F Wadsworth; Susan Joiner; Andrew Hill; Tracy A Campbell; Melanie Desbruslais; P J Luthert; John Collinge
Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay.
Lancet 2001;358(9277):171-80.
2001: Graham S Jackson; I Murray; Laszlo L P Hosszu; N Gibbs; Jonathan P Waltho; Anthony R Clarke; John Collinge
Location and properties of metal-binding sites on the human prion protein.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8531-5.
2001: John C Janssen; Peter L Lantos; Nick C Fox; Robert J Harvey; Jon Beck; Andrew Dickinson; Tracy A Campbell; John Collinge; Diane P Hanger; Lisa Cipolotti; John M Stevens; Martin N Rossor
Autopsy-confirmed familial early-onset Alzheimer disease caused by the l153V presenilin 1 mutation.
Archives of neurology 2001;58(6):953-8.
2001: Sarah E Lloyd; O N Onwuazor; Jonathan A Beck; Gary Mallinson; Martin Farrall; Paul V Targonski; John Collinge; Elizabeth M C Fisher
Identification of multiple quantitative trait loci linked to prion disease incubation period in mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6279-83.
2001: SP Mahal; Emmanuel A Asante; M Antoniou; John Collinge
Isolation and functional characterisation of the promoter region of the human prion protein gene.
Gene 2001;268(1-2):105-14.
2001: Anthony R Clarke; Graham S Jackson; John Collinge
The molecular biology of prion propagation.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1406):185-95.
2001: Andrew Hill; John Collinge
Strain variations and species barriers.
Contributions to microbiology 2001;7():48-57.
2001: Emmanuel A Asante; John Collinge
Transgenic studies of the influence of the PrP structure on TSE diseases.
Advances in protein chemistry 2001;57():273-311.
2001: John Collinge
Prion diseases of humans and animals: their causes and molecular basis.
Annual review of neuroscience 2001;24():519-50.
2000: Graham S Jackson; John Collinge
Prion disease--the propagation of infectious protein topologies.
Microbes and infection / Institut Pasteur 2000;2(12):1445-9.
2000: Andrew Hill; Susan Joiner; Jacqueline M Linehan; Melanie Desbruslais; P L Lantos; John Collinge
Species-barrier-independent prion replication in apparently resistant species.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10248-53.
2000: simon mead; Jon Beck; Andrew Dickinson; Elizabeth M C Fisher; John Collinge
Examination of the human prion protein-like gene doppel for genetic susceptibility to sporadic and variant Creutzfeldt-Jakob disease.
Neuroscience letters 2000;290(2):117-20.
2000: John C Janssen; M Hall; Nick C Fox; Robert J Harvey; Jon Beck; Andrew Dickinson; T Campbell; John Collinge; Peter L Lantos; Lisa Cipolotti; John M Stevens; Martin N Rossor
Alzheimer's disease due to an intronic presenilin-1 (PSEN1 intron 4) mutation: A clinicopathological study.
Brain : a journal of neurology 2000;123 ( Pt 5)():894-907.
1999: Giovanna Mallucci; Tracy A Campbell; Andrew Dickinson; Jon Beck; M Holt; G Plant; K W de Pauw; R N Hakin; C E Clarke; S Howell; G A B Davies-Jones; M Lawden; C M Smith; P Ince; James W Ironside; L R Bridges; A Dean; I Weeks; John Collinge
Inherited prion disease with an alanine to valine mutation at codon 117 in the prion protein gene.
Brain : a journal of neurology 1999;122 ( Pt 10)():1823-37.
1999: Laszlo L P Hosszu; Nicola J Baxter; Graham S Jackson; A Power; Anthony R Clarke; Jonathan P Waltho; C Jeremy Craven; John Collinge
Structural mobility of the human prion protein probed by backbone hydrogen exchange.
Nature structural biology 1999;6(8):740-3.
1999: John Collinge
Variant Creutzfeldt-Jakob disease.
Lancet 1999;354(9175):317-23.
1999: Jonathan D F Wadsworth; Graham S Jackson; Andrew Hill; John Collinge
Molecular biology of prion propagation.
Current opinion in genetics & development 1999;9(3):338-45.
1999: Jonathan D F Wadsworth; Andrew Hill; Susan Joiner; Graham S Jackson; Anthony R Clarke; John Collinge
Strain-specific prion-protein conformation determined by metal ions.
Nature cell biology 1999;1(1):55-9.
1999: Graham S Jackson; Andrew Hill; C Joseph; Laszlo L P Hosszu; A Power; Jonathan P Waltho; Anthony R Clarke; John Collinge
Multiple folding pathways for heterologously expressed human prion protein.
Biochimica et biophysica acta 1999;1431(1):1-13.
1999: Graham S Jackson; Laszlo L P Hosszu; A Power; Andrew Hill; J Kenney; Helen R Saibil; C Jeremy Craven; Jonathan P Waltho; Anthony R Clarke; John Collinge
Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations.
Science (New York, N.Y.) 1999;283(5409):1935-7.
1999: Andrew Hill; R J Butterworth; Susan Joiner; G Jackson; Martin N Rossor; D J Thomas; AC Frosh; Neil Samuel Tolley; J E Bell; M Spencer; A King; Safa Al-Sarraj; James W Ironside; P L Lantos; John Collinge
Investigation of variant Creutzfeldt-Jakob disease and other human prion diseases with tonsil biopsy samples.
Lancet 1999;353(9148):183-9.
1999: A Ashworth; S Lloyd; Jerry Brown; Susanne Gydesen; S A Sorensen; Arne Brun; E Englund; C Humphreys; D Housman; M Badura; V Stanton; K Taylor; J Cameron; D Munroe; J Johansson; Martin N Rossor; Elizabeth M C Fisher; John Collinge
Molecular genetic characterisation of frontotemporal dementia on chromosome 3.
Dementia and geriatric cognitive disorders 1999;10 Suppl 1():93-101.
1999: M S Palmer; Jonathan A Beck; Tracy A Campbell; C B Humphries; P K Roques; Nick C Fox; R Harvey; Martin N Rossor; John Collinge
Pathogenic presenilin 1 mutations (P436S & I143F) in early-onset Alzheimer's disease in the UK. Mutations in brief no. 223. Online.
Human mutation 1999;13(3):256.
1999: Andrew Hill; M Antoniou; John Collinge
Protease-resistant prion protein produced in vitro lacks detectable infectivity.
The Journal of general virology 1999;80 ( Pt 1)():11-4.
1998: Andrew Hill; Katie C L Sidle; Susan Joiner; P Keyes; T C Martin; M Dawson; John Collinge
Molecular screening of sheep for bovine spongiform encephalopathy.
Neuroscience letters 1998;255(3):159-62.
1998: John Collinge; Martin N Rossor; D Thomas; AC Frosh; Neil Samuel Tolley
Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum. Tonsil biopsy helps diagnose new variant Creutzfeldt-Jakob disease.
BMJ (Clinical research ed.) 1998;317(7156):472-3.
1998: E Fisher; G Telling; John Collinge
Prions and the prion disorders.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(7):497-502.
1998: R J Harvey; D Ellison; John Hardy; Michael Hutton; P K Roques; John Collinge; Nick C Fox; Martin N Rossor
Chromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine-->serine (L250S) substitution at codon 250 of the presenilin 1 gene.
Journal of neurology, neurosurgery, and psychiatry 1998;64(1):44-9.
1997: Andrew Hill; Melanie Desbruslais; Susan Joiner; Katie C L Sidle; Ian Gowland; John Collinge; LJ Doey; Peter Lantos
The same prion strain causes vCJD and BSE.
Nature 1997;389(6650):448-50, 526.
1997: Andrew Hill; R G Will; J Ironside; John Collinge
Type of prion protein in UK farmers with Creutzfeldt-Jakob disease.
Lancet 1997;350(9072):188.
1997: P L Lantos; K Bhatia; L J Doey; S al-Sarraj; R Doshi; J Beck; John Collinge
Is the neuropathology of new variant Creutzfeldt-Jakob disease and kuru similar?
Lancet 1997;350(9072):187-8.
1997: Andrew Hill; M Zeidler; J Ironside; John Collinge
Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy.
Lancet 1997;349(9045):99-100.
1997: John Collinge
Human prion diseases and bovine spongiform encephalopathy (BSE).
Human molecular genetics 1997;6(10):1699-705.
1996: John Collinge; K C Sidle; J Meads; J Ironside; Andrew Hill
Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD.
Nature 1996;383(6602):685-90.
1996: Otto Windl; M Dempster; J P Estibeiro; Richard Lathe; R De Silva; T Esmonde; Robert Will; A Springbett; Tracy A Campbell; K C Sidle; M S Palmer; John Collinge
Genetic basis of Creutzfeldt-Jakob disease in the United Kingdom: a systematic analysis of predisposing mutations and allelic variation in the PRNP gene.
Human genetics 1996;98(3):259-64.
1996: S B Colling; John Collinge; John Jefferys
Hippocampal slices from prion protein null mice: disrupted Ca(2+)-activated K+ currents.
Neuroscience letters 1996;209(1):49-52.
1996: John Collinge; Martin N Rossor
A new variant of prion disease.
Lancet 1996;347(9006):916-7.
1996: Herbert Budka; A Aguzzi; P Brown; J M Brucher; O Bugiani; John Collinge; H Diringer; F Gullotta; M Haltia; JEAN-JACQUES HAUW; J W Ironside; Hans A Kretzschmar; P L Lantos; Carlo Masullo; Maurizio Pocchiari; W Schlote; J Tateishi; Robert G Will
[Consensus report: tissue handling in suspected Creutzfeldt-Jakob disease and other spongiform encephalopathies (prion diseases) in the human. European Union Biomed-1 Concerted Action].
Der Pathologe 1996;17(2):171-5.
1996: Tracy A Campbell; M S Palmer; R G Will; W R Gibb; P J Luthert; John Collinge
A prion disease with a novel 96-base pair insertional mutation in the prion protein gene.
Neurology 1996;46(3):761-6.
1996: M S Palmer; R H van Leeven; S P Mahal; Tracy A Campbell; C B Humphreys; John Collinge
Sequence variation in intron of prion protein gene, crucial for complete diagnostic strategies.
Human mutation 1996;7(3):280-1.
1995: John Collinge; M S Palmer; K C Sidle; Andrew Hill; I Gowland; J Meads; E Asante; R Bradley; L J Doey; P L Lantos
Unaltered susceptibility to BSE in transgenic mice expressing human prion protein.
Nature 1995;378(6559):779-83.
1995: T C Britton; S al-Sarraj; C Shaw; T Campbell; John Collinge
Sporadic Creutzfeldt-Jakob disease in a 16-year-old in the UK.
Lancet 1995;346(8983):1155.
1995: J Brown; A Ashworth; S Gydesen; A Sorensen; Martin N Rossor; John Hardy; John Collinge
Familial non-specific dementia maps to chromosome 3.
Human molecular genetics 1995;4(9):1625-8.
1995: A Ashworth; J Brown; S Gydesen; S A Sorensen; Martin N Rossor; John Hardy; John Collinge
Frontal lobe or 'nonspecific' dementias are genetically heterogeneous.
Neurology 1995;45(9):1781.
1995: John Collinge; M S Palmer; K C Sidle; I Gowland; R Medori; J Ironside; P Lantos
Transmission of fatal familial insomnia to laboratory animals.
Lancet 1995;346(8974):569-70.
1995: Herbert Budka; A Aguzzi; P Brown; J M Brucher; O Bugiani; John Collinge; H Diringer; F Gullotta; M Haltia; JEAN-JACQUES HAUW
Tissue handling in suspected Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases)
Brain pathology (Zurich, Switzerland) 1995;5(3):319-22.
1995: I G Yulug; Nicholas Katsanis; Jackie de Belleroche; John Collinge; Elizabeth M C Fisher
An improved protocol for the analysis of SOD1 gene mutations, and a new mutation in exon 4.
Human molecular genetics 1995;4(6):1101-4.
1995: Henry Houlden; Richard Crook; karen duff; Michael Hutton; John Collinge; P Roques; Martin N Rossor; John Hardy
Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease.
Neuroscience letters 1995;188(3):202-4.
1995: Miles A Whittington; K C Sidle; I Gowland; J Meads; Andrew Hill; M S Palmer; John Jefferys; John Collinge
Rescue of neurophysiological phenotype seen in PrP null mice by transgene encoding human prion protein.
Nature genetics 1995;9(2):197-201.
1994: Glenn C Telling; Michael Scott; KK Hsiao; D Foster; S L Yang; M Torchia; K C Sidle; John Collinge; Stephen J DeArmond; Stanley B Prusiner
Transmission of Creutzfeldt-Jakob disease from humans to transgenic mice expressing chimeric human-mouse prion protein.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(21):9936-40.
1994: A Ashworth; T Campbell; M Palmer; John Collinge; J Brown
G/T polymorphism in CRYA2 gene.
Human molecular genetics 1994;3(9):1712.
1994: John Collinge; Miles A Whittington; K C Sidle; C J Smith; M S Palmer; Anthony R Clarke; John Jefferys
Prion protein is necessary for normal synaptic function.
Nature 1994;370(6487):295-7.
1994: Henry Houlden; Richard Crook; John Hardy; P Roques; John Collinge; Martin N Rossor
Confirmation that familial clustering and age of onset in late onset Alzheimer's disease are determined at the apolipoprotein E locus.
Neuroscience letters 1994;174(2):222-4.
1994: John Collinge; M S Palmer; K C Sidle; S P Mahal; T Campbell; J Brown; John Hardy; A E Brun; L Gustafson; E Bakker
Familial Pick's disease and dementia in frontal lobe degeneration of non-Alzheimer type are not variants of prion disease.
Journal of neurology, neurosurgery, and psychiatry 1994;57(6):762.
1994: John Collinge; M S Palmer
Molecular genetics of human prion diseases.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1994;343(1306):371-8.
1993: John Collinge; M S Palmer
Prion diseases in humans and their relevance to other neurodegenerative diseases.
Dementia (Basel, Switzerland) 1993;4(3-4):178-85.
1993: M S Palmer; S P Mahal; Tracy A Campbell; Andrew Hill; K C Sidle; J L Laplanche; John Collinge
Deletions in the prion protein gene are not associated with CJD.
Human molecular genetics 1993;2(5):541-4.
1993: J Brown; S Gydesen; S A Sorensen; A Brun; S Smith; Henry Houlden; R Twells; Michael Mullan; Martin N Rossor; John Collinge
Genetic characterization of a familial non-specific dementia originating in Jutland, Denmark.
Journal of the neurological sciences 1993;114(2):138-43.
1993: John Collinge; M S Palmer; T Campbell; K C Sidle; D Carroll; A Harding
Inherited prion disease (PrP lysine 200) in Britain: two case reports.
BMJ (Clinical research ed.) 1993;306(6873):301-2.
1993: John Collinge
Inherited prion diseases.
Advances in neurology 1993;61():155-65.
1993: M S Palmer; John Collinge
Mutations and polymorphisms in the prion protein gene.
Human mutation 1993;2(3):168-73.
1992: M S Palmer; John Collinge
Human prion diseases.
Current opinion in neurology and neurosurgery 1992;5(6):895-901.
1992: P L Lantos; I S McGill; I Janota; L J Doey; John Collinge; M T Bruce; S A Whatley; Brian H Anderton; J Clinton; G W Roberts
Prion protein immunocytochemistry helps to establish the true incidence of prion diseases.
Neuroscience letters 1992;147(1):67-71.
1992: M S Palmer; John Collinge
Human prion diseases.
Baillière's clinical neurology 1992;1(3):627-51.
1992: John Collinge; M S Palmer
Prion diseases.
Current opinion in genetics & development 1992;2(3):448-54.
1992: John Collinge; J Brown; John Hardy; Michael Mullan; Martin N Rossor; H Baker; T J Crow; R Lofthouse; M Poulter; R Ridley
Inherited prion disease with 144 base pair gene insertion. 2. Clinical and pathological features.
Brain : a journal of neurology 1992;115 ( Pt 3)():687-710.
1992: M Poulter; Harry F Baker; C D Frith; Martin Leach; R Lofthouse; Rosalind M Ridley; T Shah; F Owen; John Collinge; J Brown
Inherited prion disease with 144 base pair gene insertion. 1. Genealogical and molecular studies.
Brain : a journal of neurology 1992;115 ( Pt 3)():675-85.
1992: F Owen; M Poulter; John Collinge; Martin Leach; R Lofthouse; Timothy J Crow; A E Harding
A dementing illness associated with a novel insertion in the prion protein gene.
Brain research. Molecular brain research 1992;13(1-2):155-7.
1991: John Collinge; M Poulter; M B Davis; M Baraitser; F Owen; Timothy J Crow; A E Harding
Presymptomatic detection or exclusion of prion protein gene defects in families with inherited prion diseases.
American journal of human genetics 1991;49(6):1351-4.
1991: John Collinge; D Curtis
Decreased hippocampal expression of a glutamate receptor gene in schizophrenia.
The British journal of psychiatry : the journal of mental science 1991;159():857-9.
1991: M S Palmer; A J Dryden; J T Hughes; John Collinge
Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease.
Nature 1991;352(6333):340-2.
1991: John Collinge; M S Palmer; A J Dryden
Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease.
Lancet 1991;337(8755):1441-2.
1991: John Collinge; Lynn E DeLisi; A Boccio; E C Johnstone; A Lane; C Larkin; Martin Leach; R Lofthouse; F Owen; M Poulter
Evidence for a pseudo-autosomal locus for schizophrenia using the method of affected sibling pairs.
The British journal of psychiatry : the journal of mental science 1991;158():624-9.
1991: F Owen; M Poulter; John Collinge; Martin Leach; T Shah; R Lofthouse; Y F Chen; Timothy J Crow; A E Harding; John Hardy
Insertions in the prion protein gene in atypical dementias.
Experimental neurology 1991;112(2):240-2.
1991: J Brown; S Smith; A Brun; John Collinge; S Gydesen; John Hardy; Michael Mullan; Alison Goate
Genetic characterization of a novel familial dementia.
Annals of the New York Academy of Sciences 1991;640():181-3.
1990: John Collinge; F Owen; M Poulter; Martin Leach; Timothy J Crow; Martin N Rossor; John Hardy; Michael Mullan; I Janota; P L Lantos
Prion dementia without characteristic pathology.
Lancet 1990;336(8706):7-9.
1990: F Owen; M Poulter; John Collinge; Timothy J Crow
A codon 129 polymorphism in the PRIP gene.
Nucleic acids research 1990;18(10):3103.
1990: F Owen; M Poulter; T Shah; John Collinge; R Lofthouse; H Baker; R Ridley; J McVey; Timothy J Crow
An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease.
Brain research. Molecular brain research 1990;7(3):273-6.
1989: John Collinge; A E Harding; F Owen; M Poulter; R Lofthouse; A M Boughey; T Shah; Timothy J Crow
Diagnosis of Gerstmann-Sträussler syndrome in familial dementia with prion protein gene analysis.
Lancet 1989;2(8653):15-7.
1989: F Owen; M Poulter; R Lofthouse; John Collinge; T J Crow; D Risby; Harry F Baker; Rosalind M Ridley; Karen K. Hsiao Ashe; Stanley B Prusiner
Insertion in prion protein gene in familial Creutzfeldt-Jakob disease.
Lancet 1989;1(8628):51-2.