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Peter Colman

Research Profile

Chemicals & Drugs

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Peter Czabotar; Grant Dewson; W Douglas Fairlie; Colin Hockings; David C S Huang; Ruth M Kluck; Erinna Lee; Stephen Ma; Adeline Y Robin; Brian J Smith; Dana Westphal; Shenggen Yao; Jerry M Adams; Peter M Colman
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.
Peter M Colman
Early days in drug discovery by crystallography - personal recollections.
Toru Okamoto; John Thibault; Ninad Mehta; Michele Barry; Stephanie Campbell; Peter M Colman; David C S Huang; Marc Kvansakul
Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins.

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2013: Peter Czabotar; Grant Dewson; W Douglas Fairlie; Colin Hockings; David C S Huang; Ruth M Kluck; Erinna Lee; Stephen Ma; Adeline Y Robin; Brian J Smith; Dana Westphal; Shenggen Yao; Jerry M Adams; Peter M Colman
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.
Cell 2013;152(3):519-31.
2013: Peter M Colman
Early days in drug discovery by crystallography - personal recollections.
Acta crystallographica. Section A, Foundations of crystallography 2013;69(Pt 1):60-2.
2012: Toru Okamoto; John Thibault; Ninad Mehta; Michele Barry; Stephanie Campbell; Peter M Colman; David C S Huang; Marc Kvansakul
Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins.
Journal of virology 2012;86(21):11501-11.
2012: Jian-Guo Zhang; Soo San Wan; Jake Baum; Rajini Brammananth; Irina Caminschi; Wei Jin Chin; Peter M Colman; Ross L Coppel; Peter Czabotar; David C S Huang; Emma C Josefsson; Benjamin T Kile; Susie Kitsoulis; Jinhua Lu; Justine D Mintern; Narla Mohandas; Nicos A Nicola; Maya A Olshina; Lorraine A O'Reilly; Antonia N Policheni; Adeline Y Robin; Ken Shortman; Kirsteen M Tullett; Mark F Van Delft; Wilson Wong; Mark D Wright; Mireille Lahoud
The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments.
Immunity 2012;36(4):646-57.
2011: Erinna Lee; Matthew A Perugini; Anne Pettikiriarachchi; Brian J Smith; Peter M Colman; Grant Dewson; C Dogovski; Marco Evangelista; W Douglas Fairlie
Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins.
Structure (London, England : 1993) 2011;19(10):1467-76.
2011: Erinna Lee; Kelsey N Mayer; Brian J Smith; Peter M Colman; Marco Evangelista; Samuel H Gellman; W Seth Horne; W Douglas Fairlie
Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design.
Chembiochem : a European journal of chemical biology 2011;12(13):2025-32.
2011: Erinna Lee; Oliver B Clarke; Marco Evangelista; Zhiping Feng; Terence P Speed; Elissaveta B Tchoubrieva; Andreas Strasser; Bernd H Kalinna; Peter M Colman; W Douglas Fairlie
Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(17):6999-7003.
2010: Marc Kvansakul; Andrew H Wei; Jamie I Fletcher; Simon N Willis; Lin Chen; Andrew W Roberts; David C S Huang; Peter M Colman
Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
PLoS pathogens 2010;6(12):e1001236.
2009: Erinna Lee; Anna Fedorova; Kerry Zobel; Michelle J Boyle; Hong Yang; Matthew A Perugini; Peter M Colman; David C S Huang; Kurt Deshayes; W Douglas Fairlie
Novel Bcl-2 homology-3 domain-like sequences identified from screening randomized peptide libraries for inhibitors of the pro-survival Bcl-2 proteins.
The Journal of biological chemistry 2009;284(45):31315-26.
2009: Erinna F Lee; Peter Czabotar; Hong Yang; Brad E Sleebs; Guillaume Lessene; Peter M Colman; Brian J Smith; W Douglas Fairlie
Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.
The Journal of biological chemistry 2009;284(44):30508-17.
2009: Anthony N Hodder; Robyn L Malby; Oliver B Clarke; W Douglas Fairlie; Peter M Colman; Brendan S Crabb; Brian J Smith
Structural insights into the protease-like antigen Plasmodium falciparum SERA5 and its noncanonical active-site serine.
Journal of molecular biology 2009;392(1):154-65.
2009: Peter Czabotar; Peter M Colman; David C S Huang
Bax activation by Bim?
Cell death and differentiation 2009;16(9):1187-91.
2009: Peter M Colman
New antivirals and drug resistance.
Annual review of biochemistry 2009;78():95-118.
2008: Guillaume Lessene; Peter E Czabotar; Peter M Colman
BCL-2 family antagonists for cancer therapy.
Nature reviews. Drug discovery 2008;7(12):989-1000.
2008: Grant Dewson; Tobias Kratina; Huiyan W Sim; Hamsa Puthalakath; Jerry M Adams; Peter M Colman; Ruth M Kluck
To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.
Molecular cell 2008;30(3):369-80.
2008: Erinna Lee; Peter Czabotar; Mark F Van Delft; Ewa M Michalak; Michelle J Boyle; Simon N Willis; Hamsa Puthalakath; Philippe Bouillet; Peter M Colman; David C S Huang; W Douglas Fairlie
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
The Journal of cell biology 2008;180(2):341-55.
2007: Erinna Lee; Peter Czabotar; Brian J Smith; Kurt Deshayes; Kerry Zobel; Peter M Colman; W Douglas Fairlie
Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family.
Cell death and differentiation 2007;14(9):1711-3.
2007: Peter Czabotar; Erinna Lee; Mark F Van Delft; Catherine L Day; Brian J Smith; David C S Huang; W Douglas Fairlie; Mark G Hinds; Peter M Colman
Structural insights into the degradation of Mcl-1 induced by BH3 domains.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6217-22.
2007: Marc Kvansakul; Mark F Van Delft; Erinna Lee; Jacqueline M Gulbis; W Douglas Fairlie; David C S Huang; Peter M Colman
A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.
Molecular cell 2007;25(6):933-42.
2006: Lukasz Kedzierski; Robyn L Malby; Brian J Smith; Matthew A Perugini; Anthony N Hodder; Thomas Ilg; Peter M Colman; Emanuela Handman
Structure of Leishmania mexicana phosphomannomutase highlights similarities with human isoforms.
Journal of molecular biology 2006;363(1):215-27.
2006: W Douglas Fairlie; Matthew A Perugini; Marc Kvansakul; Lin Chen; David C S Huang; Peter M Colman
CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13.
Cell death and differentiation 2006;13(3):426-34.
2005: Jacqueline F Satchell; Robyn L Malby; Cindy S Luo; Akinola Adisa; Aysun E Alpyurek; Nectarios Klonis; Brian J Smith; Leann Tilley; Peter M Colman
Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum.
Acta crystallographica. Section D, Biological crystallography 2005;61(Pt 9):1213-21.
2005: Peter M Colman
Zanamivir: an influenza virus neuraminidase inhibitor.
Expert review of anti-infective therapy 2005;3(2):191-9.
2005: Lin Chen; Simon N Willis; Andrew Wei; Brian J Smith; Jamie I Fletcher; Mark G Hinds; Peter M Colman; Catherine L Day; Jerry M Adams; David C S Huang
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.
Molecular cell 2005;17(3):393-403.
2005: Jerry M Adams; David C S Huang; Andreas Strasser; S Willis; Lin Chen; Andrew Wei; Mark F Van Delft; Jamie I Fletcher; Hamsa Puthalakath; Junya Kuroda; Ewa M Michalak; Priscilla N Kelly; Philippe Bouillet; Andreas Villunger; Lorraine A O'Reilly; Mary L Bath; Darrin P Smith; Alexander Egle; Alan W Harris; Mark G Hinds; Peter M Colman; Suzanne Cory
Subversion of the Bcl-2 life/death switch in cancer development and therapy.
Cold Spring Harbor symposia on quantitative biology 2005;70():469-77.
2004: Michael C Lawrence; Natalie A Borg; Victor A Streltsov; Patricia A Pilling; V Chandana Epa; Joseph N Varghese; Jennifer L McKimm-Breschkin; Peter M Colman
Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III.
Journal of molecular biology 2004;335(5):1343-57.
2003: Jennifer L McKimm-Breschkin; Peter M Colman; Betty Jin; Guy Y Krippner; Mandy McDonald; Phillip A Reece; Simon P Tucker; Lynne Waddington; Keith G Watson; Wen-Yang Wu
Tethered neuraminidase inhibitors that bind an influenza virus: a first step towards a diagnostic method for influenza.
Angewandte Chemie (International ed. in English) 2003;42(27):3118-21.
2003: Peter M Colman; Michael C Lawrence
The structural biology of type I viral membrane fusion.
Nature reviews. Molecular cell biology 2003;4(4):309-19.
2002: Brian J Smith; Jennifer L McKimm-Breshkin; Mandy McDonald; Ross T Fernley; Joseph N Varghese; Peter M Colman
Structural studies of the resistance of influenza virus neuramindase to inhibitors.
Journal of medicinal chemistry 2002;45(11):2207-12.
2002: Brian J Smith; Michael C Lawrence; Peter M Colman
Modelling the structure of the fusion protein from human respiratory syncytial virus.
Protein engineering 2002;15(5):365-71.
2001: L Chen; Peter M Colman; Leah J Cosgrove; Michael C Lawrence; Lynne J Lawrence; PA Tulloch; Jeffrey J Gorman
Cloning, expression, and crystallization of the fusion protein of Newcastle disease virus.
Virology 2001;290(2):290-9.
2001: Brian J Smith; Peter M Colman; Mark von Itzstein; B Danylec; Joseph N Varghese
Analysis of inhibitor binding in influenza virus neuraminidase.
Protein science : a publication of the Protein Society 2001;10(4):689-96.
2001: P G Wyatt; B A Coomber; D N Evans; T I Jack; H E Fulton; Alan J Wonacott; Peter M Colman; J Varghese
Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides.
Bioorganic & medicinal chemistry letters 2001;11(5):669-73.
2001: L Chen; Jeffrey J Gorman; Jennifer L McKimm-Breschkin; Lynne J Lawrence; PA Tulloch; Brian J Smith; Peter M Colman; Michael C Lawrence
The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion.
Structure (London, England : 1993) 2001;9(3):255-66.
2001: V Chandana Epa; Peter M Colman
Shape and electrostatic complementarity at viral antigen-antibody complexes.
Current topics in microbiology and immunology 2001;260():45-53.
1999: Peter M Colman
A novel approach to antiviral therapy for influenza.
The Journal of antimicrobial chemotherapy 1999;44 Suppl B():17-22.
1998: Anjali Sahasrabudhe; L Lawrence; V Chandana Epa; Joseph N Varghese; Peter M Colman; Jennifer L McKimm-Breschkin
Substrate, inhibitor, or antibody stabilizes the Glu 119 Gly mutant influenza virus neuraminidase.
Virology 1998;247(1):14-21.
1998: Robyn L Malby; AJ McCoy; Alexander A Kortt; Peter J Hudson; Peter M Colman
Three-dimensional structures of single-chain Fv-neuraminidase complexes.
Journal of molecular biology 1998;279(4):901-10.
1998: Joseph N Varghese; Paul W Smith; SL Sollis; TJ Blick; Anjali Sahasrabudhe; Jennifer L McKimm-Breschkin; Peter M Colman
Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
Structure (London, England : 1993) 1998;6(6):735-46.
1998: N R Taylor; Anne Cleasby; Onkar M P Singh; T Skarzynski; Alan J Wonacott; Paul W Smith; SL Sollis; PD Howes; P C Cherry; RC Bethell; Peter M Colman; J Varghese
Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.
Journal of medicinal chemistry 1998;41(6):798-807.
1998: Jennifer L McKimm-Breschkin; Anjali Sahasrabudhe; TJ Blick; Mandy McDonald; Peter M Colman; Graham Hart; R C Bethell; Joseph N Varghese
Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors.
Journal of virology 1998;72(3):2456-62.
1997: Joseph N Varghese; Peter M Colman; A van Donkelaar; TJ Blick; Anjali Sahasrabudhe; Jennifer L McKimm-Breschkin
Structural evidence for a second sialic acid binding site in avian influenza virus neuraminidases.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(22):11808-12.
1997: Peter M Colman
Virus versus antibody.
Structure (London, England : 1993) 1997;5(5):591-3.
1997: AJ McCoy; V Chandana Epa; Peter M Colman
Electrostatic complementarity at protein/protein interfaces.
Journal of molecular biology 1997;268(2):570-84.
1996: Jennifer L McKimm-Breschkin; M McDonald; TJ Blick; Peter M Colman
Mutation in the influenza virus neuraminidase gene resulting in decreased sensitivity to the neuraminidase inhibitor 4-guanidino-Neu5Ac2en leads to instability of the enzyme.
Virology 1996;225(1):240-2.
1995: TJ Blick; T Tiong; Anjali Sahasrabudhe; Joseph N Varghese; Peter M Colman; Graham Hart; R C Bethell; Jennifer L McKimm-Breschkin
Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en.
Virology 1995;214(2):475-84.
1995: Joseph N Varghese; V Chandana Epa; Peter M Colman
Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase.
Protein science : a publication of the Protein Society 1995;4(6):1081-7.
1994: Peter M Colman
Structure-based drug design.
Current opinion in structural biology 1994;4(6):868-74.
1994: Peter M Colman
Influenza virus neuraminidase: structure, antibodies, and inhibitors.
Protein science : a publication of the Protein Society 1994;3(10):1687-96.
1994: Robyn L Malby; W R Tulip; V R Harley; Jennifer L McKimm-Breschkin; W Graeme Laver; R G Webster; Peter M Colman
The structure of a complex between the NC10 antibody and influenza virus neuraminidase and comparison with the overlapping binding site of the NC41 antibody.
Structure (London, England : 1993) 1994;2(8):733-46.
1994: Michael C Lawrence; T Izard; M Beuchat; R J Blagrove; Peter M Colman
Structure of phaseolin at 2.2 A resolution. Implications for a common vicilin/legumin structure and the genetic engineering of seed storage proteins.
Journal of molecular biology 1994;238(5):748-76.
1994: T Izard; Michael C Lawrence; Robyn L Malby; G G Lilley; Peter M Colman
The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli.
Structure (London, England : 1993) 1994;2(5):361-9.
1994: Alexander A Kortt; Robyn L Malby; J B Caldwell; LC Gruen; N Ivancic; Michael C Lawrence; G J Howlett; R G Webster; Peter J Hudson; Peter M Colman
Recombinant anti-sialidase single-chain variable fragment antibody. Characterization, formation of dimer and higher-molecular-mass multimers and the solution of the crystal structure of the single-chain variable fragment/sialidase complex.
European journal of biochemistry / FEBS 1994;221(1):151-7.
1994: Joseph N Varghese; T P Garrett; Peter M Colman; L Chen; Peter B Høj; Geoffrey B Fincher
Three-dimensional structures of two plant beta-glucan endohydrolases with distinct substrate specificities.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2785-9.
1994: Peter M Colman
Effects of amino acid sequence changes on antibody-antigen interactions.
Research in immunology 1994;145(1):33-6.
1993: Michael C Lawrence; Peter M Colman
Shape complementarity at protein/protein interfaces.
Journal of molecular biology 1993;234(4):946-50.
1993: Peter M Colman; P A Hoyne; Michael C Lawrence
Sequence and structure alignment of paramyxovirus hemagglutinin-neuraminidase with influenza virus neuraminidase.
Journal of virology 1993;67(6):2972-80.
1993: Robyn L Malby; J B Caldwell; LC Gruen; V R Harley; N Ivancic; Alexander A Kortt; G G Lilley; B E Power; R G Webster; Peter M Colman
Recombinant antineuraminidase single chain antibody: expression, characterization, and crystallization in complex with antigen.
Proteins 1993;16(1):57-63.
1992: Joseph N Varghese; Jennifer L McKimm-Breschkin; J B Caldwell; Alexander A Kortt; Peter M Colman
The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor.
Proteins 1992;14(3):327-32.
1992: W R Tulip; Joseph N Varghese; R G Webster; W Graeme Laver; Peter M Colman
Crystal structures of two mutant neuraminidase-antibody complexes with amino acid substitutions in the interface.
Journal of molecular biology 1992;227(1):149-59.
1992: W R Tulip; Joseph N Varghese; W Graeme Laver; R G Webster; Peter M Colman
Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex.
Journal of molecular biology 1992;227(1):122-48.
1992: Peter M Colman
Structural basis of antigenic variation: studies of influenza virus neuraminidase.
Immunology and cell biology 1992;70 ( Pt 3)():209-14.
1991: W R Tulip; Joseph N Varghese; A T Baker; A van Donkelaar; W Graeme Laver; R G Webster; Peter M Colman
Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutants.
Journal of molecular biology 1991;221(2):487-97.
1991: Joseph N Varghese; Peter M Colman
Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 A resolution.
Journal of molecular biology 1991;221(2):473-86.
1990: Michael C Lawrence; E Suzuki; Joseph N Varghese; P C Davis; A Van Donkelaar; PA Tulloch; Peter M Colman
The three-dimensional structure of the seed storage protein phaseolin at 3 A resolution.
The EMBO journal 1990;9(1):9-15.
1989: Peter M Colman; W R Tulip; Joseph N Varghese; PA Tulloch; A T Baker; W Graeme Laver; Gillian M Air; R G Webster
Three-dimensional structures of influenza virus neuraminidase-antibody complexes.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1989;323(1217):511-8.
1989: W R Tulip; Joseph N Varghese; R G Webster; Gillian M Air; W Graeme Laver; Peter M Colman
Crystal structures of neuraminidase-antibody complexes.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():257-63.
1988: Joseph N Varghese; R G Webster; W Graeme Laver; Peter M Colman
Structure of an escape mutant of glycoprotein N2 neuraminidase of influenza virus A/Tokyo/3/67 at 3 A.
Journal of molecular biology 1988;200(1):201-3.
1988: Peter M Colman
Structure of antibody-antigen complexes: implications for immune recognition.
Advances in immunology 1988;43():99-132.
1987: R G Webster; Gillian M Air; D W Metzger; Peter M Colman; Joseph N Varghese; A T Baker; W Graeme Laver
Antigenic structure and variation in an influenza virus N9 neuraminidase.
Journal of virology 1987;61(9):2910-6.
1987: Peter M Colman; W Graeme Laver; Joseph N Varghese; A T Baker; PA Tulloch; Gillian M Air; R G Webster
Three-dimensional structure of a complex of antibody with influenza virus neuraminidase.
Nature 1987;326(6111):358-63.
1987: A T Baker; Joseph N Varghese; W Graeme Laver; Gillian M Air; Peter M Colman
Three-dimensional structure of neuraminidase of subtype N9 from an avian influenza virus.
Proteins 1987;2(2):111-7.
1986: PA Tulloch; Peter M Colman; P C Davis; W Graeme Laver; R G Webster; Gillian M Air
Electron and X-ray diffraction studies of influenza neuraminidase complexed with monoclonal antibodies.
Journal of molecular biology 1986;190(2):215-25.
1983: Joseph N Varghese; W Graeme Laver; Peter M Colman
Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution.
Nature 1983;303(5912):35-40.
1983: Peter M Colman; Joseph N Varghese; W Graeme Laver
Structure of the catalytic and antigenic sites in influenza virus neuraminidase.
Nature 1983;303(5912):41-4.
1983: E Suzuki; A Van Donkelaar; J N Varghese; G G Lilley; R J Blagrove; Peter M Colman
Crystallization of phaseolin from Phaseolus vulgaris.
The Journal of biological chemistry 1983;258(4):2634-6.
1981: Peter M Colman; Keith H Gough; G G Lilley; R J Blagrove; R G Webster; W G Laver
Crystalline monoclonal fab fragment with specificity towards an influenza virus neuraminidase.
Journal of molecular biology 1981;152(3):609-14.
1980: Peter M Colman; PA Tulloch; D D Shukla; Keith H Gough
Particle and crystal symmetry of Erysimum latent virus.
Journal of molecular biology 1980;142(2):263-8.
1980: Peter M Colman; E Suzuki; A Van Donkelaar
The structure of cucurbitin: subunit symmetry and organization in situ.
European journal of biochemistry / FEBS 1980;103(3):585-8.