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Mario Colombo
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40
Parmiani, Giorgio
39
Melani, Cecilia
19
Chiodoni, Claudia
19
Stoppacciaro, Antonella
18
Musiani, Piero
17
Parenza, Mariella
13
Forni, Guido
13
Rodolfo, Monica
12
Lollini, Pier-Luigi
12
Di Carlo, Emma
11
Arienti, Flavio
11
Guiducci, Cristiana
11
Rivoltini, Licia
10
Nanni, Patrizia
10
Cavallo, Federica
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All Publications
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2009: Piconese Silvia; Gri Giorgia; Tripodo Claudio; Musio Silvia; Gorzanelli Andrea; Frossi Barbara; Pedotti Rosetta; Pucillo Carlo E; Colombo Mario P
Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation.
Blood 2009;114(13):2639-48.
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2009: Colombo Mario P; Piconese Silvia
Polyps wrap mast cells and Treg within tumorigenic tentacles.
Cancer research 2009;69(14):5619-22.
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2008: Gri Giorgia; Piconese Silvia; Frossi Barbara; Manfroi Vanessa; Merluzzi Sonia; Tripodo Claudio; Viola Antonella; Odom Sandra; Rivera Juan; Colombo Mario P; Pucillo Carlo E
CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction.
Immunity 2008;29(5):771-81.
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2008: Sangaletti Sabina; Di Carlo Emma; Gariboldi Silvia; Miotti Silvia; Cappetti Barbara; Parenza Mariella; Rumio Cristiano; Brekken Rolf A; Chiodoni Claudia; Colombo Mario P
Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis.
Cancer research 2008;68(21):9050-9.
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2008: Sangaletti Sabina; Colombo Mario P
Matricellular proteins at the crossroad of inflammation and cancer.
Cancer letters 2008;267(2):245-53.
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2008: Felicetti Federica; Errico M Cristina; Bottero Lisabianca; Segnalini Patrizia; Stoppacciaro Antonella; Biffoni Mauro; Felli Nadia; Mattia Gianfranco; Petrini Marina; Colombo Mario P; Peschle Cesare; Carè Alessandra
The promyelocytic leukemia zinc finger-microRNA-221/-222 pathway controls melanoma progression through multiple oncogenic mechanisms.
Cancer research 2008;68(8):2745-54.
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2008: Piconese Silvia; Valzasina Barbara; Colombo Mario P
OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection.
The Journal of experimental medicine 2008;205(4):825-39.
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2008: Rotta Gianluca; Matteoli Gianluca; Mazzini Elisa; Nuciforo Paolo; Colombo Mario P; Rescigno Maria
Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity.
The Journal of experimental medicine 2008;205(3):657-67.
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2007: Melani Cecilia; Sangaletti Sabina; Barazzetta Francesca M; Werb Zena; Colombo Mario P
Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma.
Cancer research 2007;67(23):11438-46.
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2007: Colombo Mario P; Piconese Silvia
Regulatory-T-cell inhibition versus depletion: the right choice in cancer immunotherapy.
Nature reviews. Cancer 2007;7(11):880-7.
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2007: Cantiani Lara; Manara Maria Cristina; Zucchini Cinzia; De Sanctis Paola; Zuntini Monia; Valvassori Luisa; Serra Massimo; Olivero Martina; Di Renzo Maria Flavia; Colombo Mario Paolo; Picci Piero; Scotlandi Katia
Caveolin-1 reduces osteosarcoma metastases by inhibiting c-Src activity and met signaling.
Cancer research 2007;67(16):7675-85.
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2007: Curti Antonio; Pandolfi Simona; Valzasina Barbara; Aluigi Michela; Isidori Alessandro; Ferri Elisa; Salvestrini Valentina; Bonanno Giuseppina; Rutella Sergio; Durelli Ilaria; Horenstein Alberto L; Fiore Francesca; Massaia Massimo; Colombo Mario P; Baccarani Michele; Lemoli Roberto M
Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25- into CD25+ T regulatory cells.
Blood 2007;109(7):2871-7.
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2006: Chiodoni Claudia; Iezzi Manuela; Guiducci Cristiana; Sangaletti Sabina; Alessandrini Isabella; Ratti Chiara; Tiboni Francesca; Musiani Piero; Granger D Neil; Colombo Mario P
Triggering CD40 on endothelial cells contributes to tumor growth.
The Journal of experimental medicine 2006;203(11):2441-50.
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2006: Gallina Giovanna; Dolcetti Luigi; Serafini Paolo; De Santo Carmela; Marigo Ilaria; Colombo Mario P; Basso Giuseppe; Brombacher Frank; Borrello Ivan; Zanovello Paola; Bicciato Silvio; Bronte Vincenzo
Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells.
The Journal of clinical investigation 2006;116(10):2777-90.
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2006: Valzasina Barbara; Piconese Silvia; Guiducci Cristiana; Colombo Mario P
Tumor-induced expansion of regulatory T cells by conversion of CD4+CD25- lymphocytes is thymus and proliferation independent.
Cancer research 2006;66(8):4488-95.
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2006: Manara Maria Cristina; Bernard Ghislaine; Lollini Pier-Luigi; Nanni Patrizia; Zuntini Monia; Landuzzi Lorena; Benini Stefania; Lattanzi Giovanna; Sciandra Marika; Serra Massimo; Colombo Mario Paolo; Bernard Alain; Picci Piero; Scotlandi Katia
CD99 acts as an oncosuppressor in osteosarcoma.
Molecular biology of the cell 2006;17(4):1910-21.
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2006: Comes Alberto; Rosso Ombretta; Orengo Anna Maria; Di Carlo Emma; Sorrentino Carlo; Meazza Raffaella; Piazza Tiziana; Valzasina Barbara; Nanni Patrizia; Colombo Mario P; Ferrini Silvano
CD25+ regulatory T cell depletion augments immunotherapy of micrometastases by an IL-21-secreting cellular vaccine.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(3):1750-8.
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2006: Aluigi Michela; Fogli Miriam; Curti Antonio; Isidori Alessandro; Gruppioni Elisa; Chiodoni Claudia; Colombo Mario P; Versura Piera; D'Errico-Grigioni Antonia; Ferri Elisa; Baccarani Michele; Lemoli Roberto M
Nucleofection is an efficient nonviral transfection technique for human bone marrow-derived mesenchymal stem cells.
Stem cells (Dayton, Ohio) 2006;24(2):454-61.
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2005: Curti Antonio; Pandolfi Simona; Aluigi Michela; Isidori Alessandro; Alessandrini Isabella; Chiodoni Claudia; Testoni Nicoletta; Colombo Mario P; Baccarani Michele; Lemoli Roberto M
Interleukin-12 production by leukemia-derived dendritic cells counteracts the inhibitory effect of leukemic microenvironment on T cells.
Experimental hematology 2005;33(12):1521-30.
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2005: Airoldi Irma; Di Carlo Emma; Cocco Claudia; Sorrentino Carlo; Fais Franco; Cilli Michele; D'Antuono Tommaso; Colombo Mario Paolo; Pistoia Vito
Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancy.
Blood 2005;106(12):3846-53.
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2005: Airoldi Irma; Di Carlo Emma; Cocco Claudia; Sorrentino Carlo; Fais Franco; Cilli Michele; D'Antuono Tommaso; Colombo Mario Paolo; Pistoia Vito
Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancy.
Blood 2005;106(12):3846-53.
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2005: Colombo Mario P; Mantovani Alberto
Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion.
Cancer research 2005;65(20):9113-6.
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2005: Massa Chiara; Melani Cecilia; Colombo Mario P
Chaperon and adjuvant activity of hsp70: different natural killer requirement for cross-priming of chaperoned and bystander antigens.
Cancer research 2005;65(17):7942-9.
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2005: Sangaletti Sabina; Gioiosa Lucia; Guiducci Cristiana; Rotta Gianluca; Rescigno Maria; Stoppacciaro Antonella; Chiodoni Claudia; Colombo Mario P
Accelerated dendritic-cell migration and T-cell priming in SPARC-deficient mice.
Journal of cell science 2005;118(Pt 16):3685-94.
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2005: Benini Stefania; Perbal Bernard; Zambelli Diana; Colombo Mario Paolo; Manara Maria Cristina; Serra Massimo; Parenza Mariella; Martinez Vincent; Picci Piero; Scotlandi Katia
In Ewing's sarcoma CCN3(NOV) inhibits proliferation while promoting migration and invasion of the same cell type.
Oncogene 2005;24(27):4349-61.
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2005: Avogadri Francesca; Martinoli Chiara; Petrovska Liljana; Chiodoni Claudia; Transidico Pietro; Bronte Vincenzo; Longhi Renato; Colombo Mario P; Dougan Gordon; Rescigno Maria
Cancer immunotherapy based on killing of Salmonella-infected tumor cells.
Cancer research 2005;65(9):3920-7.
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2005: Guiducci Cristiana; Vicari Alain P; Sangaletti Sabina; Trinchieri Giorgio; Colombo Mario P
Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection.
Cancer research 2005;65(8):3437-46.
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2005: Valzasina Barbara; Guiducci Cristiana; Dislich Heidrun; Killeen Nigel; Weinberg Andrew D; Colombo Mario P
Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR.
Blood 2005;105(7):2845-51.
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2005: Dalerba Piero; Guiducci Cristiana; Poliani Pietro Luigi; Cifola Ingrid; Parenza Mariella; Frattini Milo; Gallino Gianfrancesco; Carnevali Ileana; Di Giulio Ilvia; Andreola Salvatore; Lombardo Claudia; Rivoltini Licia; Schweighoffer Tamás; Belli Filiberto; Colombo Mario P; Parmiani Giorgio; Castelli Chiara
Reconstitution of human telomerase reverse transcriptase expression rescues colorectal carcinoma cells from in vitro senescence: evidence against immortality as a constitutive trait of tumor cells.
Cancer research 2005;65(6):2321-9.
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2005: De Santo Carmela; Serafini Paolo; Marigo Ilaria; Dolcetti Luigi; Bolla Manlio; Del Soldato Piero; Melani Cecilia; Guiducci Cristiana; Colombo Mario P; Iezzi Manuela; Musiani Piero; Zanovello Paola; Bronte Vincenzo
Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(11):4185-90.
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2005: Guiducci Cristiana; Valzasina Barbara; Dislich Heidrun; Colombo Mario P
CD40/CD40L interaction regulates CD4+CD25+ T reg homeostasis through dendritic cell-produced IL-2.
European journal of immunology 2005;35(2):557-67.
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2004: Sfondrini Lucia; Besusso Dario; Bronte Vincenzo; Macino Beatrice; Rossini Anna; Colombo Mario Paolo; Ménard Sylvie; Balsari Andrea
CpG-Oligodeoxynucleotides activate tyrosinase-related protein 2-specific T lymphocytes but do not lead to a protective tumor-specific memory response.
Cancer immunology, immunotherapy : CII 2004;53(8):697-704.
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2004: Cerisano Vanessa; Aalto Yan; Perdichizzi Stefania; Bernard Ghislaine; Manara Maria Cristina; Benini Stefania; Cenacchi Giovanna; Preda Paola; Lattanzi Giovanna; Nagy Bálint; Knuutila Sakari; Colombo Mario Paolo; Bernard Alain; Picci Piero; Scotlandi Katia
Molecular mechanisms of CD99-induced caspase-independent cell death and cell-cell adhesion in Ewing's sarcoma cells: actin and zyxin as key intracellular mediators.
Oncogene 2004;23(33):5664-74.
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2004: Melani Cecilia; Stoppacciaro Antonella; Foroni Chiara; Felicetti Federica; Caré Alessandra; Colombo Mario P
Angiopoietin decoy secreted at tumor site impairs tumor growth and metastases by inducing local inflammation and altering neoangiogenesis.
Cancer immunology, immunotherapy : CII 2004;53(7):600-8.
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2004: Felicetti Federica; Bottero Lisabianca; Felli Nadia; Mattia Gianfranco; Labbaye Catherine; Alvino Ester; Peschle Cesare; Colombo Mario P; Carè Alessandra
Role of PLZF in melanoma progression.
Oncogene 2004;23(26):4567-76.
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2004: Guiducci Cristiana; Di Carlo Emma; Parenza Mariella; Hitt Mary; Giovarelli Mirella; Musiani Piero; Colombo Mario P
Intralesional injection of adenovirus encoding CC chemokine ligand 16 inhibits mammary tumor growth and prevents metastatic-induced death after surgical removal of the treated primary tumor.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(7):4026-36.
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2004: Massa Chiara; Guiducci Cristiana; Arioli Ivano; Parenza Mariella; Colombo Mario P; Melani Cecilia
Enhanced efficacy of tumor cell vaccines transfected with secretable hsp70.
Cancer research 2004;64(4):1502-8.
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2004: Di Carlo Emma; Comes Alberto; Orengo Anna Maria; Rosso Ombretta; Meazza Raffaella; Musiani Piero; Colombo Mario P; Ferrini Silvano
IL-21 induces tumor rejection by specific CTL and IFN-gamma-dependent CXC chemokines in syngeneic mice.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1540-7.
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2004: Vicari Alain P; Vanbervliet Béatrice; Massacrier Catherine; Chiodoni Claudia; Vaure Céline; Aït-Yahia Smina; Dercamp Christophe; Matsos Fabien; Reynard Olivier; Taverne Catherine; Merle Philippe; Colombo Mario P; O'Garra Anne; Trinchieri Giorgio; Caux Christophe
In vivo manipulation of dendritic cell migration and activation to elicit antitumour immunity.
Novartis Foundation symposium 2004;256():241-54; discussion 254-69.
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2003: Sangaletti Sabina; Stoppacciaro Antonella; Guiducci Cristiana; Torrisi Maria Rosaria; Colombo Mario P
Leukocyte, rather than tumor-produced SPARC, determines stroma and collagen type IV deposition in mammary carcinoma.
The Journal of experimental medicine 2003;198(10):1475-85.
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2003: Rotta Gianluca; Edwards Emmerson W; Sangaletti Sabina; Bennett Clare; Ronzoni Simona; Colombo Mario P; Steinman Ralph M; Randolph Gwendalyn J; Rescigno Maria
Lipopolysaccharide or whole bacteria block the conversion of inflammatory monocytes into dendritic cells in vivo.
The Journal of experimental medicine 2003;198(8):1253-63.
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2003: Melani Cecilia; Chiodoni Claudia; Forni Guido; Colombo Mario P
Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity.
Blood 2003;102(6):2138-45.
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2003: Curcio Claudia; Di Carlo Emma; Clynes Raphael; Smyth Mark J; Boggio Katia; Quaglino Elena; Spadaro Michela; Colombo Mario P; Amici Augusto; Lollini Pier-Luigi; Musiani Piero; Forni Guido
Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas.
The Journal of clinical investigation 2003;111(8):1161-70.
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2003: Meccia Ettore; Bottero Lisabianca; Felicetti Federica; Peschle Cesare; Colombo Mario P; Carè Alessandra
HOXB7 expression is regulated by the transcription factors NF-Y, YY1, Sp1 and USF-1.
Biochimica et biophysica acta 2003;1626(1-3):1-9.
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2003: Bronte Vincenzo; Serafini Paolo; De Santo Carmela; Marigo Ilaria; Tosello Valeria; Mazzoni Alessandra; Segal David M; Staib Caroline; Lowel Marianne; Sutter Gerd; Colombo Mario P; Zanovello Paola
IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):270-8.
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2003: Gri Giorgia; Gallo Elena; Di Carlo Emma; Musiani Piero; Colombo Mario P
OX40 ligand-transduced tumor cell vaccine synergizes with GM-CSF and requires CD40-Apc signaling to boost the host T cell antitumor response.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(1):99-106.
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2003: Curti Antonio; Parenza Mariella; Colombo Mario P
Autologous and MHC class I-negative allogeneic tumor cells secreting IL-12 together cure disseminated A20 lymphoma.
Blood 2003;101(2):568-75.
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2002: Vicari Alain P; Chiodoni Claudia; Vaure Céline; Aït-Yahia Smina; Dercamp Christophe; Matsos Fabien; Reynard Olivier; Taverne Catherine; Merle Philippe; Colombo Mario P; O'Garra Anne; Trinchieri Giorgio; Caux Christophe
Reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor antibody.
The Journal of experimental medicine 2002;196(4):541-9.
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2002: Gri Giorgia; Chiodoni Claudia; Gallo Elena; Stoppacciaro Antonella; Liew Foo Y; Colombo Mario P
Antitumor effect of interleukin (IL)-12 in the absence of endogenous IFN-gamma: a role for intrinsic tumor immunogenicity and IL-15.
Cancer research 2002;62(15):4390-7.
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2002: Curti A; Colombo M P; Baccarani M; Lemoli R M
Transduction of MHC-class I negative allogeneic cell line to improve the efficacy of anti-tumor vaccination.
Journal of biological regulators and homeostatic agents 2002;16(3):236-40.
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2002: Comes Alberto; Di Carlo Emma; Musiani Piero; Rosso Ombretta; Meazza Raffaella; Chiodoni Claudia; Colombo Mario P; Ferrini Silvano
IFN-gamma-independent synergistic effects of IL-12 and IL-15 induce anti-tumor immune responses in syngeneic mice.
European journal of immunology 2002;32(7):1914-23.
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2002: Sfondrini Lucia; Besusso Dario; Zoia Maria Teresa; Rodolfo Monica; Invernizzi Anna Maria; Taniguchi Masaru; Nakayama Toshinori; Colombo Mario Paolo; Ménard Sylvie; Balsari Andrea
Absence of the CD1 molecule up-regulates antitumor activity induced by CpG oligodeoxynucleotides in mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):151-8.
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2002: Colombo Mario P; Trinchieri Giorgio
Interleukin-12 in anti-tumor immunity and immunotherapy.
Cytokine & growth factor reviews 2002;13(2):155-68.
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2002: Maio Michele; Fonsatti Ester; Lamaj Elda; Altomonte Maresa; Cattarossi Ilaria; Santantonio Cristina; Melani Cecilia; Belli Filiberto; Arienti Flavio; Colombo Mario P; Parmiani Giorgio
Vaccination of stage IV patients with allogeneic IL-4- or IL-2-gene-transduced melanoma cells generates functional antibodies against vaccinating and autologous melanoma cells.
Cancer immunology, immunotherapy : CII 2002;51(1):9-14.
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2001: Nanni P; Nicoletti G; De Giovanni C; Landuzzi L; Di Carlo E; Cavallo F; Pupa S M; Rossi I; Colombo M P; Ricci C; Astolfi A; Musiani P; Forni G; Lollini P L
Combined allogeneic tumor cell vaccination and systemic interleukin 12 prevents mammary carcinogenesis in HER-2/neu transgenic mice.
The Journal of experimental medicine 2001;194(9):1195-205.
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2001: Gavallo F; Di Carlo E; Quaglin E; Jezzi M; Strasly M; Bussolino F; Colombo M P; Nanni P; Lollini P L; Musiani P; Forni G
Prevention by delay: nonspecific immunity elicited by IL-12 hinders Her-2/neu mammary carcinogenesis in transgenic mice.
Journal of biological regulators and homeostatic agents 2001;15(4):351-8.
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2001: Chiodoni C; Stoppacciaro A; Sangaletti S; Gri G; Cappetti B; Koezuka Y; Colombo M P
Different requirements for alpha-galactosylceramide and recombinant IL-12 antitumor activity in the treatment of C-26 colon carcinoma hepatic metastases.
European journal of immunology 2001;31(10):3101-10.
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2001: Carè A; Felicetti F; Meccia E; Bottero L; Parenza M; Stoppacciaro A; Peschle C; Colombo M P
HOXB7: a key factor for tumor-associated angiogenic switch.
Cancer research 2001;61(17):6532-9.
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2001: Mazzocchi A; Melani C; Rivoltini L; Castelli C; Del Vecchio M; Lombardo C; Colombo M P; Parmiani G
Simultaneous transduction of B7-1 and IL-2 genes into human melanoma cells to be used as vaccine: enhancement of stimulatory activity for autologous and allogeneic lymphocytes.
Cancer immunology, immunotherapy : CII 2001;50(4):199-211.
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2001: Strasly M; Cavallo F; Geuna M; Mitola S; Colombo M P; Forni G; Bussolino F
IL-12 inhibition of endothelial cell functions and angiogenesis depends on lymphocyte-endothelial cell cross-talk.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3890-9.
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2000: Coral S; Fonsatti E; Sigalotti L; De Nardo C; Visintin A; Nardi G; Colizzi F; Colombo M P; Romano G; Altomonte M; Maio M
Overexpression of protectin (CD59) down-modulates the susceptibility of human melanoma cells to homologous complement.
Journal of cellular physiology 2000;185(3):317-23.
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2000: Rovero S; Amici A; Di Carlo E; Bei R; Nanni P; Quaglino E; Porcedda P; Boggio K; Smorlesi A; Lollini P L; Landuzzi L; Colombo M P; Giovarelli M; Musiani P; Forni G
DNA vaccination against rat her-2/Neu p185 more effectively inhibits carcinogenesis than transplantable carcinomas in transgenic BALB/c mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):5133-42.
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2000: Paglia P; Terrazzini N; Schulze K; Guzmán C A; Colombo M P
In vivo correction of genetic defects of monocyte/macrophages using attenuated Salmonella as oral vectors for targeted gene delivery.
Gene therapy 2000;7(20):1725-30.
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2000: Montosi G; Paglia P; Garuti C; Guzman C A; Bastin J M; Colombo M P; Pietrangelo A
Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis.
Blood 2000;96(3):1125-9.
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2000: Sfondrini L; Rodolfo M; Singh M; Colombo M P; Colnaghi M I; Ménard S; Balsari A
Cooperative effects of Mycobacterium tuberculosis Ag38 gene transduction and interleukin 12 in vaccination against spontaneous tumor development in proto-neu transgenic mice.
Cancer research 2000;60(14):3777-81.
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2000: Forni G; Lollini P L; Musiani P; Colombo M P
Immunoprevention of cancer: is the time ripe?
Cancer research 2000;60(10):2571-5.
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2000: Medina E; Paglia P; Rohde M; Colombo M P; Guzmán C A
Modulation of host immune responses stimulated by Salmonella vaccine carrier strains by using different promoters to drive the expression of the recombinant antigen.
European journal of immunology 2000;30(3):768-77.
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1999: Arienti F; Belli F; Napolitano F; Sulé-Suso J; Mazzocchi A; Gallino G F; Cattelan A; Santantonio C; Rivoltini L; Melani C; Colombo M P; Cascinelli N; Maio M; Parmiani G;
Vaccination of melanoma patients with interleukin 4 gene-transduced allogeneic melanoma cells.
Human gene therapy 1999;10(18):2907-16.
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1999: Rodolfo M; Colombo M P
Interleukin-12 as an adjuvant for cancer immunotherapy.
Methods (San Diego, Calif.) 1999;19(1):114-20.
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1999: Rodolfo M; Zilocchi C; Accornero P; Cappetti B; Arioli I; Colombo M P
IL-4-transduced tumor cell vaccine induces immunoregulatory type 2 CD8 T lymphocytes that cure lung metastases upon adoptive transfer.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1923-8.
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1999: Chiodoni C; Paglia P; Stoppacciaro A; Rodolfo M; Parenza M; Colombo M P
Dendritic cells infiltrating tumors cotransduced with granulocyte/macrophage colony-stimulating factor (GM-CSF) and CD40 ligand genes take up and present endogenous tumor-associated antigens, and prime naive mice for a cytotoxic T lymphocyte response.
The Journal of experimental medicine 1999;190(1):125-33.
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1999: Neglia F; Orengo A M; Cilli M; Meazza R; Tomassetti A; Canevari S; Melani C; Colombo M P; Ferrini S
DNA vaccination against the ovarian carcinoma-associated antigen folate receptor alpha (FRalpha) induces cytotoxic T lymphocyte and antibody responses in mice.
Cancer gene therapy 1999;6(4):349-57.
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1999: Sard L; Accornero P; Tornielli S; Delia D; Bunone G; Campiglio M; Colombo M P; Gramegna M; Croce C M; Pierotti M A; Sozzi G
The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8489-92.
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1999: Rodolfo M; Zilocchi C; Cappetti B; Parmiani G; Melani C; Colombo M P
Cytotoxic T lymphocyte response against non-immunoselected tumor antigens predicts the outcome of gene therapy with IL-12-transduced tumor cell vaccine.
Gene therapy 1999;6(5):865-72.
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1999: Fonsatti E; Lamaj E; Coral S; Sigalotti L; Nardi G; Gasparollo A; Colombo M P; Altomonte M; Maio M
In vitro analysis of the melanoma/endothelium interaction increasing the release of soluble intercellular adhesion molecule 1 by endothelial cells.
Cancer immunology, immunotherapy : CII 1999;48(2-3):132-8.
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1999: Carè A; Valtieri M; Mattia G; Meccia E; Masella B; Luchetti L; Felicetti F; Colombo M P; Peschle C
Enforced expression of HOXB7 promotes hematopoietic stem cell proliferation and myeloid-restricted progenitor differentiation.
Oncogene 1999;18(11):1993-2001.
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1999: Medina E; Guzmán C A; Staendner L H; Colombo M P; Paglia P
Salmonella vaccine carrier strains: effective delivery system to trigger anti-tumor immunity by oral route.
European journal of immunology 1999;29(2):693-9.
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1999: Cavallo F; Di Carlo E; Butera M; Verrua R; Colombo M P; Musiani P; Forni G
Immune events associated with the cure of established tumors and spontaneous metastases by local and systemic interleukin 12.
Cancer research 1999;59(2):414-21.
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1998: Di Carlo E; Modesti A; Coletti A; Colombo M P; Giovarelli M; Forni G; Diodoro M G; Musiani P
Interaction between endothelial cells and the secreted cytokine drives the fate of an IL4- or an IL5-transduced tumour.
The Journal of pathology 1998;186(4):390-7.
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1998: Rodolfo M; Melani C; Zilocchi C; Cappetti B; Luison E; Arioli I; Parenza M; Canevari S; Colombo M P
IgG2a induced by interleukin (IL) 12-producing tumor cell vaccines but not IgG1 induced by IL-4 vaccine is associated with the eradication of experimental metastases.
Cancer research 1998;58(24):5812-7.
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1998: Belardelli F; Ferrantini M; Santini S M; Baccarini S; Proietti E; Colombo M P; Sprent J; Tough D F
The induction of in vivo proliferation of long-lived CD44hi CD8+ T cells after the injection of tumor cells expressing IFN-alpha1 into syngeneic mice.
Cancer research 1998;58(24):5795-802.
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1998: Paglia P; Medina E; Arioli I; Guzman C A; Colombo M P
Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma.
Blood 1998;92(9):3172-6.
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1998: Accornero P; Radrizzani M; Carè A; Mattia G; Chiodoni C; Kurrle R; Colombo M P
HIV/gp120 and PMA/ionomycin induced apoptosis but not activation induced cell death require PKC for Fas-L upregulation.
FEBS letters 1998;436(3):461-5.
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1998: Melani C; Figini M; Nicosia D; Luison E; Ramakrishna V; Casorati G; Parmiani G; Eshhar Z; Canevari S; Colombo M P
Targeting of interleukin 2 to human ovarian carcinoma by fusion with a single-chain Fv of antifolate receptor antibody.
Cancer research 1998;58(18):4146-54.
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1998: Boggio K; Nicoletti G; Di Carlo E; Cavallo F; Landuzzi L; Melani C; Giovarelli M; Rossi I; Nanni P; De Giovanni C; Bouchard P; Wolf S; Modesti A; Musiani P; Lollini P L; Colombo M P; Forni G
Interleukin 12-mediated prevention of spontaneous mammary adenocarcinomas in two lines of Her-2/neu transgenic mice.
The Journal of experimental medicine 1998;188(3):589-96.
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1998: Rivoltini L; Radrizzani M; Accornero P; Squarcina P; Chiodoni C; Mazzocchi A; Castelli C; Tarsini P; Viggiano V; Belli F; Colombo M P; Parmiani G
Human melanoma-reactive CD4+ and CD8+ CTL clones resist Fas ligand-induced apoptosis and use Fas/Fas ligand-independent mechanisms for tumor killing.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(3):1220-30.
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1998: Zilocchi C; Stoppacciaro A; Chiodoni C; Parenza M; Terrazzini N; Colombo M P
Interferon gamma-independent rejection of interleukin 12-transduced carcinoma cells requires CD4+ T cells and Granulocyte/Macrophage colony-stimulating factor.
The Journal of experimental medicine 1998;188(1):133-43.
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1998: Caré A; Silvani A; Meccia E; Mattia G; Peschle C; Colombo M P
Transduction of the SkBr3 breast carcinoma cell line with the HOXB7 gene induces bFGF expression, increases cell proliferation and reduces growth factor dependence.
Oncogene 1998;16(25):3285-9.
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1998: Colombo M P
Tumor and dendritic cells as cellular vaccines: confrontation and perspectives--a symposium in writing.
Cancer immunology, immunotherapy : CII 1998;46(2):69.
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1998: Nanni P; Rossi I; De Giovanni C; Landuzzi L; Nicoletti G; Stoppacciaro A; Parenza M; Colombo M P; Lollini P L
Interleukin 12 gene therapy of MHC-negative murine melanoma metastases.
Cancer research 1998;58(6):1225-30.
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1997: Stoppacciaro A; Paglia P; Lombardi L; Parmiani G; Baroni C; Colombo M P
Genetic modification of a carcinoma with the IL-4 gene increases the influx of dendritic cells relative to other cytokines.
European journal of immunology 1997;27(9):2375-82.
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1997: Radrizzani M; Accornero P; Delia D; Kurrle R; Colombo M P
Apoptosis induced by HIV-gp120 in a Th1 clone involves the generation of reactive oxygen intermediates downstream CD95 triggering.
FEBS letters 1997;411(1):87-92.
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1997: Cavallo F; Signorelli P; Giovarelli M; Musiani P; Modesti A; Brunda M J; Colombo M P; Forni G
Antitumor efficacy of adenocarcinoma cells engineered to produce interleukin 12 (IL-12) or other cytokines compared with exogenous IL-12.
Journal of the National Cancer Institute 1997;89(14):1049-58.
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1997: Belli F; Arienti F; Sulé-Suso J; Clemente C; Mascheroni L; Cattelan A; Santantonio C; Gallino G F; Melani C; Rao S; Colombo M P; Maio M; Cascinelli N; Parmiani G;
Active immunization of metastatic melanoma patients with interleukin-2-transduced allogeneic melanoma cells: evaluation of efficacy and tolerability.
Cancer immunology, immunotherapy : CII 1997;44(4):197-203.
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1997: Paglia P; Arioli I; Frahm N; Chakraborty T; Colombo M P; Guzmàn C A
The defined attenuated Listeria monocytogenes delta mp12 mutant is an effective oral vaccine carrier to trigger a long-lasting immune response against a mouse fibrosarcoma.
European journal of immunology 1997;27(6):1570-5.
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1997: Musiani P; Modesti A; Giovarelli M; Cavallo F; Colombo M P; Lollini P L; Forni G
Cytokines, tumour-cell death and immunogenicity: a question of choice.
Immunology today 1997;18(1):32-6.
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1997: Accornero P; Radrizzani M; Delia D; Gerosa F; Kurrle R; Colombo M P
Differential susceptibility to HIV-GP120-sensitized apoptosis in CD4+ T-cell clones with different T-helper phenotypes: role of CD95/CD95L interactions.
Blood 1997;89(2):558-69.
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1997: Parmiani G; Colombo M P; Melani C; Arienti F
Cytokine gene transduction in the immunotherapy of cancer.
Advances in pharmacology (San Diego, Calif.) 1997;40():259-307.
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1996: Rodolfo M; Zilocchi C; Melani C; Cappetti B; Arioli I; Parmiani G; Colombo M P
Immunotherapy of experimental metastases by vaccination with interleukin gene-transduced adenocarcinoma cells sharing tumor-associated antigens. Comparison between IL-12 and IL-2 gene-transduced tumor cell vaccines.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5536-42.
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1996: Arienti F; Sulé-Suso J; Belli F; Mascheroni L; Rivoltini L; Melani C; Maio M; Cascinelli N; Colombo M P; Parmiani G
Limited antitumor T cell response in melanoma patients vaccinated with interleukin-2 gene-transduced allogeneic melanoma cells.
Human gene therapy 1996;7(16):1955-63.
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1996: Caré A; Silvani A; Meccia E; Mattia G; Stoppacciaro A; Parmiani G; Peschle C; Colombo M P
HOXB7 constitutively activates basic fibroblast growth factor in melanomas.
Molecular and cellular biology 1996;16(9):4842-51.
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1996: Colombo M P; Vagliani M; Spreafico F; Parenza M; Chiodoni C; Melani C; Stoppacciaro A
Amount of interleukin 12 available at the tumor site is critical for tumor regression.
Cancer research 1996;56(11):2531-4.
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1996: Colombo M P; Lombardi L; Melani C; Parenza M; Baroni C; Ruco L; Stoppacciaro A
Hypoxic tumor cell death and modulation of endothelial adhesion molecules in the regression of granulocyte colony-stimulating factor-transduced tumors.
The American journal of pathology 1996;148(2):473-83.
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1996: Vagliani M; Rodolfo M; Cavallo F; Parenza M; Melani C; Parmiani G; Forni G; Colombo M P
Interleukin 12 potentiates the curative effect of a vaccine based on interleukin 2-transduced tumor cells.
Cancer research 1996;56(3):467-70.
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1996: Paglia P; Chiodoni C; Rodolfo M; Colombo M P
Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.
The Journal of experimental medicine 1996;183(1):317-22.
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1996: Parmiani G; Arienti F; Sulé-Suso J; Melani C; Colombo M P; Ramakrishna V; Belli F; Mascheroni L; Rivoltini L; Cascinelli N
Cytokine-based gene therapy of human tumors. An overview.
Folia biologica 1996;42(6):305-9.
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1995: Melani C; Sulé-Suso J; Arienti F; MacCalli C; Passerini F; Colombo M P; Parmiani G
A human melanoma cell line transduced with an interleukin-4 gene by a retroviral vector releases biologically active IL-4 and maintains the original tumor antigenic phenotype.
Human gene therapy 1995;6(11):1427-36.
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1995: Colombo M P; Rodolfo M
Tumor cells engineered to produce cytokines or cofactors as cellular vaccines: do animal studies really support clinical trials?
Cancer immunology, immunotherapy : CII 1995;41(5):265-70.
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1995: De Giovanni C; Melani C; Nanni P; Landuzzi L; Nicoletti G; Frabetti F; Griffoni C; Colombo M P; Lollini P L
Redundancy of autocrine loops in human rhabdomyosarcoma cells: induction of differentiation by suramin.
British journal of cancer 1995;72(5):1224-9.
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1995: Parmiani G; Colombo M P
Somatic gene therapy of human melanoma: preclinical studies and early clinical trials.
Melanoma research 1995;5(5):295-301.
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1995: Sulé-Suso J; Arienti F; Melani C; Colombo M P; Parmiani G
A B7-1-transfected human melanoma line stimulates proliferation and cytotoxicity of autologous and allogeneic lymphocytes.
European journal of immunology 1995;25(10):2737-42.
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1995: Melani C; Pupa S M; Stoppacciaro A; Ménard S; Colnaghi M I; Parmiani G; Colombo M P
An in vivo model to compare human leukocyte infiltration in carcinoma xenografts producing different chemokines.
International journal of cancer. Journal international du cancer 1995;62(5):572-8.
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1995: Silvani A; Ferrari G; Paonessa G; Toniatti C; Parmiani G; Colombo M P
Down-regulation of interleukin 6 receptor alpha chain in interleukin 6 transduced melanoma cells causes selective resistance to interleukin 6 but not to oncostatin M.
Cancer research 1995;55(10):2200-5.
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1995: Radrizzani M; Accornero P; Amidei A; Aiello A; Delia D; Kurrle R; Colombo M P
IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation.
Cellular immunology 1995;161(1):14-21.
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1995: Martinotti A; Stoppacciaro A; Vagliani M; Melani C; Spreafico F; Wysocka M; Parmiani G; Trinchieri G; Colombo M P
CD4 T cells inhibit in vivo the CD8-mediated immune response against murine colon carcinoma cells transduced with interleukin-12 genes.
European journal of immunology 1995;25(1):137-46.
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1994: Pericle F; Giovarelli M; Colombo M P; Ferrari G; Musiani P; Modesti A; Cavallo F; Di Pierro F; Novelli F; Forni G
An efficient Th2-type memory follows CD8+ lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mammary adenocarcinoma engineered to release IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(12):5659-73.
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1994: Allione A; Consalvo M; Nanni P; Lollini P L; Cavallo F; Giovarelli M; Forni M; Gulino A; Colombo M P; Dellabona P
Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants.
Cancer research 1994;54(23):6022-6.
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1994: Arienti F; Sulé-Suso J; Melani C; Maccalli C; Belli F; Illeni M T; Anichini A; Cascinelli N; Colombo M P; Parmiani G
Interleukin-2 gene-transduced human melanoma cells efficiently stimulate MHC-unrestricted and MHC-restricted autologous lymphocytes.
Human gene therapy 1994;5(9):1139-50.
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1994: Melani C; Chiodoni C; Arienti F; Maccalli C; Sule-Suso J; Anichini A; Colombo M P; Parmiani G
Cytokine gene transduction in tumor cells: interleukin (IL)-2 or IL-4 gene transfer in human melanoma cells.
Natural immunity 1994;13(2-3):76-84.
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1994: Carè A; Mattia G; Montesoro E; Parolini I; Russo G; Colombo M P; Peschle C
c-fes expression in ontogenetic development and hematopoietic differentiation.
Oncogene 1994;9(3):739-47.
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1994: Mattei S; Colombo M P; Melani C; Silvani A; Parmiani G; Herlyn M
Expression of cytokine/growth factors and their receptors in human melanoma and melanocytes.
International journal of cancer. Journal international du cancer 1994;56(6):853-7.
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1994: Ferrero M; Desiderio M A; Martinotti A; Melani C; Bernelli-Zazzera A; Colombo M P; Cairo G
Expression of a growth arrest specific gene (gas-6) during liver regeneration: molecular mechanisms and signalling pathways.
Journal of cellular physiology 1994;158(2):263-9.
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1994: Vagliani M; D'Eustachio P; Colombo M P
Refined localization of H7 and Ctt1 on distal mouse chromosome 9.
Immunogenetics 1994;40(1):79-81.
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1994: Stoppacciaro A; Forni G; Colombo M P
Different tumours, transduced with different cytokine genes as G-CSF and IL-2, show inhibition of tumour take through neutrophil activation but differ in T cell functions.
Folia biologica 1994;40(1-2):89-99.
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1993: Forni G; Giovarelli M; Cavallo F; Consalvo M; Allione A; Modesti A; Musiani P; Colombo M P
Cytokine-induced tumor immunogenicity: from exogenous cytokines to gene therapy.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1993;14(4):253-7.
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1993: Melani C; Silvani A; Parmiani G; Colombo M P
Lymphotoxin gene expression by melanocytes and melanoma cell lines and persistence of unspliced mRNA.
FEBS letters 1993;335(1):114-8.
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1993: Desiderio M A; Mattei S; Biondi G; Colombo M P
Cytosolic and nuclear spermidine acetyltransferases in growing NIH 3T3 fibroblasts stimulated with serum or polyamines: relationship to polyamine-biosynthetic decarboxylases and histone acetyltransferase.
The Biochemical journal 1993;293 ( Pt 2)():475-9.
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1993: Stoppacciaro A; Melani C; Parenza M; Mastracchio A; Bassi C; Baroni C; Parmiani G; Colombo M P
Regression of an established tumor genetically modified to release granulocyte colony-stimulating factor requires granulocyte-T cell cooperation and T cell-produced interferon gamma.
The Journal of experimental medicine 1993;178(1):151-61.
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1993: Melani C; Mattia G F; Silvani A; Carè A; Rivoltini L; Parmiani G; Colombo M P
Interleukin-6 expression in human neutrophil and eosinophil peripheral blood granulocytes.
Blood 1993;81(10):2744-9.
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1993: Rivoltini L; Viggiano V; Spinazzè S; Santoro A; Colombo M P; Takatsu K; Parmiani G
In vitro anti-tumor activity of eosinophils from cancer patients treated with subcutaneous administration of interleukin 2. Role of interleukin 5.
International journal of cancer. Journal international du cancer 1993;54(1):8-15.
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1993: Vagliani M; Melani C; Parmiani G; D'Eustachio P; Wettstein P J; Colombo M P
Immunodominance in the T-cell response to multiple non-H-2 histocompatibility antigens. V. Chromosomal mapping of the immunodominant cytotoxic T-cell target-1 (CTT-1).
Immunogenetics 1993;38(2):157-60.
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1992: Colombo M P; Modesti A; Parmiani G; Forni G
Local cytokine availability elicits tumor rejection and systemic immunity through granulocyte-T-lymphocyte cross-talk.
Cancer research 1992;52(18):4853-7.
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1992: Colombo M P; Maccalli C; Mattei S; Melani C; Radrizzani M; Parmiani G
Expression of cytokine genes, including IL-6, in human malignant melanoma cell lines.
Melanoma research 1992;2(3):181-9.
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1992: Martinotti A; Cariani C T; Melani C; Sozzi G; Spurr N K; Pierotti M A; Colombo M P
Isolation and mapping to 17p12-13 of the human homologous of the murine growth arrest specific Gas-3 gene.
Human molecular genetics 1992;1(5):331-4.
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1992: Cairo G; Ferrero M; Biondi G; Colombo M P
Expression of a growth arrest specific gene (gas-1) in transformed cells.
British journal of cancer 1992;66(1):27-31.
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1992: Colombo M P; Lombardi L; Stoppacciaro A; Melani C; Parenza M; Bottazzi B; Parmiani G
Granulocyte colony-stimulating factor (G-CSF) gene transduction in murine adenocarcinoma drives neutrophil-mediated tumor inhibition in vivo. Neutrophils discriminate between G-CSF-producing and G-CSF-nonproducing tumor cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(1):113-9.
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1992: Colombo M P; Mattei S; Parmiani G
Cytokine gene transfer in tumor cells as an approach to antitumor therapy.
International journal of clinical & laboratory research 1992;21(4):278-82.
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1992: Colombo M P; Martinotti A; Howard T A; Schneider C; D'Eustachio P; Seldin M F
Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16.
Mammalian genome : official journal of the International Mammalian Genome Society 1992;2(2):130-4.
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1991: Melani C; Rivoltini L; Parmiani G; Calabretta B; Colombo M P
Inhibition of proliferation by c-myb antisense oligodeoxynucleotides in colon adenocarcinoma cell lines that express c-myb.
Cancer research 1991;51(11):2897-901.
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1991: Colombo M P; Ferrari G; Stoppacciaro A; Parenza M; Rodolfo M; Mavilio F; Parmiani G
Granulocyte colony-stimulating factor gene transfer suppresses tumorigenicity of a murine adenocarcinoma in vivo.
The Journal of experimental medicine 1991;173(4):889-97.
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1991: Rivoltini L; Cattoretti G; Arienti F; Mastroianni A; Melani C; Colombo M P; Parmiani G
The high lysability by LAK cells of colon-carcinoma cells resistant to doxorubicin is associated with a high expression of ICAM-1, LFA-3, NCA and a less-differentiated phenotype.
International journal of cancer. Journal international du cancer 1991;47(5):746-54.
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1991: Colombo M P; Ferrari G; Biondi G; Galasso D; Howe C C; Parmiani G
Down-regulation of SPARC/osteonectin/BM-40 expression in methylcholanthrene-induced fibrosarcomas and in Kirsten-MSV transformed fibroblasts.
European journal of cancer (Oxford, England : 1990) 1991;27(1):58-62.
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1991: Rodolfo M; Salvi C; Bassi C; Rovetta G; Melani C; Colombo M P; Parmiani G
Adjuvant adoptive immunotherapy with IL2 and lymphocytes from tumor-bearing mice: in vitro tumor-stimulated lymphocytes are more effective than LAK cells.
Natural immunity and cell growth regulation 1991;10(6):308-19.
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1990: Desiderio M A; Lugaro G; Galasso D; Colombo M P
Effect of adrenergic and Ca2+ antagonists on increased ornithine decarboxylase expression in regenerating rat liver.
Biochemical pharmacology 1990;40(7):1605-13.
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1990: Rivoltini L; Colombo M P; Supino R; Ballinari D; Tsuruo T; Parmiani G
Modulation of multidrug resistance by verapamil or mdr1 anti-sense oligodeoxynucleotide does not change the high susceptibility to lymphokine-activated killers in mdr-resistant human carcinoma (LoVo) line.
International journal of cancer. Journal international du cancer 1990;46(4):727-32.
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1989: Colombo M P; Baracetti P; Cairo G; Schneider C; Parmiani G
A TaqI RFLP at the gas-2 locus.
Nucleic acids research 1989;17(18):7545.
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1989: Colombo M P; Baracetti P; Schneider C; Cairo G
Ava I RFLP at the gas-1 locus on mouse chromosome 12.
Nucleic acids research 1989;17(13):5415.
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1989: Colombo M P; Biondi G; Galasso D; Baracetti P; Howe C C; Parmiani G
Osteonectin transcript and metastatic behavior in v-Ki-ras transformed fibroblasts.
International journal of cancer. Supplement = Journal international du cancer. Supplement 1989;4():76-7.
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1988: Colombo M P; Galasso D; Ferrari G; Parmiani G
Strain polymorphism and tentative mapping of mouse ornithine decarboxylase.
Nucleic acids research 1988;16(18):9075.
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1988: Colombo M P; Ferrari G; Parmiani G; Wettstein P J
Retroviral heterogeneity in mouse lymphomas.
Oncogene 1988;2(4):395-8.
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1985: Lollini P L; Colombo M P; De Giovanni C; Nicoletti G; Parmiani G; Prodi G; Nanni P
In vivo reexpression of H-2 antigens in B16 melanoma cells.
Experimental and clinical immunogenetics 1985;2(1):14-23.
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