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Michael Colvin

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Chemicals & Drugs

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TOP 3
Michael P Gamcsik; Mohit S Kasibhatla; Stephanie D Teeter; O Michael Colvin
Glutathione levels in human tumors.
Urban Emmenegger; Yuval Shaked; Shan Man; Guido Bocci; Ivan Spasojevic; Giulio Francia; Andrew Kouri; Robert Coke; William Cruz-Munoz; Susan M Ludeman; O Michael Colvin; Robert S Kerbel
Pharmacodynamic and pharmacokinetic study of chronic low-dose metronomic cyclophosphamide therapy in mice.
Lisa C Campbell; Francis J Keefe; Cindy D Scipio; Daphne C McKee; Christopher L Edwards; Steven H Herman; Lawrence E Johnson; O Michael Colvin; Colleen M McBride; Craig F Donatucci
Facilitating research participation and improving quality of life for African American prostate cancer survivors and their intimate partners. A pilot study of telephone-based coping skills training.

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All Publications

2012: Michael P Gamcsik; Mohit S Kasibhatla; Stephanie D Teeter; O Michael Colvin
Glutathione levels in human tumors.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2012;17(8):671-91.
2007: Urban Emmenegger; Yuval Shaked; Shan Man; Guido Bocci; Ivan Spasojevic; Giulio Francia; Andrew Kouri; Robert Coke; William Cruz-Munoz; Susan M Ludeman; O Michael Colvin; Robert S Kerbel
Pharmacodynamic and pharmacokinetic study of chronic low-dose metronomic cyclophosphamide therapy in mice.
Molecular cancer therapeutics 2007;6(8):2280-9.
2007: Lisa C Campbell; Francis J Keefe; Cindy D Scipio; Daphne C McKee; Christopher L Edwards; Steven H Herman; Lawrence E Johnson; O Michael Colvin; Colleen M McBride; Craig F Donatucci
Facilitating research participation and improving quality of life for African American prostate cancer survivors and their intimate partners. A pilot study of telephone-based coping skills training.
Cancer 2007;109(2 Suppl):414-24.
2006: Benjamin L Viglianti; Ana Ponce Kiess; Charles R Michelich; Daohai Yu; Sheela A Abraham; Linda Sanders; Pavel Yarmolenko; Thies Schroeder; James R MacFall; Daniel P Barboriak; O Michael Colvin; Marcel B Bally; Mark Dewhirst
Chemodosimetry of in vivo tumor liposomal drug concentration using MRI.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2006;56(5):1011-8.
2006: Ivan Spasojević; O Michael Colvin; Keith R Warshany; Ines Batinić-Haberle
New approach to the activation of anti-cancer pro-drugs by metalloporphyrin-based cytochrome P450 mimics in all-aqueous biologically relevant system.
Journal of inorganic biochemistry 2006;100(11):1897-902.
2006: David J Adams; Mateus Webba da Silva; James L Flowers; Glenda Kohlhagen; Yves Pommier; O Michael Colvin; Govindarajan Manikumar; Mansukh C Wani
Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex.
Cancer chemotherapy and pharmacology 2006;57(2):135-44.
2005: William P Petros; Penelope J Hopkins; Susan Spruill; Gloria Broadwater; James J Vredenburgh; O Michael Colvin; William P Peters; Roy B Jones; Jeff Hall; Jeffrey R Marks
Associations between drug metabolism genotype, chemotherapy pharmacokinetics, and overall survival in patients with breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(25):6117-25.
2005: Mateus Webba da Silva; Ross G Bierbryer; Christopher J Wilds; Anne M Noronha; O Michael Colvin; Paul S Miller; Michael P Gamcsik
Intrastrand base-stacking buttresses widening of major groove in interstrand cross-linked B-DNA.
Bioorganic & medicinal chemistry 2005;13(14):4580-7.
2005: Robert W Storms; Patrick D Green; Kristine M Safford; Donna Niedzwiecki; Christopher R Cogle; O Michael Colvin; Nelson J Chao; Henry E Rice; Clayton A Smith
Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34.
Blood 2005;106(1):95-102.
2005: Ryan H Shanks; David A Rizzieri; James L Flowers; O Michael Colvin; David J Adams
Preclinical evaluation of gemcitabine combination regimens for application in acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(11):4225-33.
2005: David M Noll; Mateus Webba da Silva; Anne M Noronha; Christopher J Wilds; O Michael Colvin; Michael P Gamcsik; Paul S Miller
Structure, flexibility, and repair of two different orientations of the same alkyl interstrand DNA cross-link.
Biochemistry 2005;44(18):6764-75.
2004: Lisa C Campbell; Francis J Keefe; Daphne C McKee; Christopher L Edwards; Steven H Herman; Lawrence E Johnson; O Michael Colvin; Colleen M McBride; Craig F Donattuci
Prostate cancer in African Americans: relationship of patient and partner self-efficacy to quality of life.
Journal of pain and symptom management 2004;28(5):433-44.
2004: Mateus Webba da Silva; Christopher J Wilds; Anne M Noronha; O Michael Colvin; Paul S Miller; Michael P Gamcsik
Accommodation of mispair aligned N3T-ethyl-N3T DNA interstrand cross link.
Biochemistry 2004;43(39):12549-54.
2004: James B Springer; Young H Chang; Kyo I Koo; O Michael Colvin; Michael Colvin; M Eileen Dolan; Shannon M Delaney; James L Flowers; Susan M Ludeman
1,3- vs 1,5-intramolecular alkylation reactions in isophosphoramide and phosphoramide mustards.
Chemical research in toxicology 2004;17(9):1217-26.
2004: Manny Bacolod; Stewart P Johnson; Anthony E Pegg; M Eileen Dolan; Robert C Moschel; Nancy S Bullock; Qingming Fang; O Michael Colvin; Paul Modrich; Darell D Bigner; Henry S Friedman
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
Molecular cancer therapeutics 2004;3(9):1127-35.
2004: Elizabeth Grubbs; Omar I Abdel-Wahab; Tsung-Yen Cheng; Zeinab Abdel-Wahab; Bercedis Peterson; Scott K Pruitt; O Michael Colvin; Henry S Friedman; Douglas S Tyler
In-transit melanoma: the role of alkylating-agent resistance in regional therapy.
Journal of the American College of Surgeons 2004;199(3):419-27.
2004: Ramsis K Benjamin; Fred H Hochberg; Elizabeth Fox; Peter M Bungay; William F Elmquist; Clinton F Stewart; James M Gallo; Jerry M Collins; Robert P Pelletier; John F de Groot; Robert C Hickner; Idil Cavus; Stuart A Grossman; O Michael Colvin
Review of microdialysis in brain tumors, from concept to application: first annual Carolyn Frye-Halloran symposium.
Neuro-oncology 2004;6(1):65-74.
2003: James L Flowers; Robert M Hoffman; Timothy A Driscoll; Monroe E Wall; Mansukh C Wani; Govindarajan Manikumar; Henry S Friedman; Mark Dewhirst; O Michael Colvin; David J Adams
The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH.
Cancer chemotherapy and pharmacology 2003;52(3):253-61.
2003: Janie A Ho; Chrisley V Pickens; Michael P Gamcsik; O Michael Colvin; Russell E Ware; Michael P Gamscik
In vitro induction of fetal hemoglobin in human erythroid progenitor cells.
Experimental hematology 2003;31(7):586-91.
2003: O Michael Colvin
Adventures with an enigmatic anticancer drug.
Cancer biology & therapy 2003;2(3):301-3.
2002: Mateus Webba da Silva; Anne M Noronha; David M Noll; Paul S Miller; O Michael Colvin; Michael P Gamcsik
Solution structure of a DNA duplex containing mispair-aligned N4C-ethyl-N4C interstrand cross-linked cytosines.
Biochemistry 2002;41(51):15181-8.
2002: Henry S Friedman; Stephen T Keir; Anthony E Pegg; Peter J Houghton; O Michael Colvin; Robert C Moschel; Darell D Bigner; M Eileen Dolan
O6-benzylguanine-mediated enhancement of chemotherapy.
Molecular cancer therapeutics 2002;1(11):943-8.
2002: Manny Bacolod; Stewart P Johnson; Francis Ali-Osman; Paul Modrich; Nancy S Bullock; O Michael Colvin; Darell D Bigner; Henry S Friedman
Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma.
Molecular cancer therapeutics 2002;1(9):727-36.
2002: Jennifer A Quinn; James Pluda; M Eileen Dolan; Shannon M Delaney; Richard S. Kaplan; Jeremy Rich; Allan H Friedman; David A Reardon; John H Sampson; O Michael Colvin; Michael M Haglund; Anthony E Pegg; Robert C Moschel; Roger E McLendon; James M Provenzale; Sridharan Gururangan; Sandra Tourt-Uhlig; James E Herndon; Darell D Bigner; Henry S Friedman
Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(9):2277-83.
2002: Kevin O Clarke; Susan M Ludeman; James B Springer; O Michael Colvin; Michael A Lea; Lawrence E Harrison
Exposure to a deuterated analogue of phenylbutyrate retards S-phase progression in HT-29 colon cancer cells.
Journal of pharmaceutical sciences 2002;91(4):1054-64.
2002: Narayanan Balu; Michael P Gamcsik; Michael Colvin; O Michael Colvin; M Eileen Dolan; Susan M Ludeman
Modified guanines representing O(6)-alkylation by the cyclophosphamide metabolites acrolein and chloroacetaldehyde: synthesis, stability, and ab initio studies.
Chemical research in toxicology 2002;15(3):380-7.
2002: William P Petros; Gloria Broadwater; Donald Berry; Roy B Jones; James J Vredenburgh; Colleen J Gilbert; John P Gibbs; O Michael Colvin; William P Peters
Association of high-dose cyclophosphamide, cisplatin, and carmustine pharmacokinetics with survival, toxicity, and dosing weight in patients with primary breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(3):698-705.
2002: Henry S Friedman; Stewart P Johnson; O Michael Colvin
Cellular mechanisms of cyclophosphamide resistance: model studies in human medulloblastoma cell lines.
Cancer treatment and research 2002;112():199-209.
2001: David J Adams; Marc C Levesque; J Brice Weinberg; K L Smith; James L Flowers; J Moore; O Michael Colvin; R Silber
Nitric oxide enhancement of fludarabine cytotoxicity for B-CLL lymphocytes.
Leukemia 2001;15(12):1852-9.
2001: Michael P Gamcsik; Mohit S Kasibhatla; David J Adams; James L Flowers; O Michael Colvin; Govindarajan Manikumar; M Wani; Monroe E Wall; Glenda Kohlhagen; Yves Pommier
Dual role of glutathione in modulating camptothecin activity: depletion potentiates activity, but conjugation enhances the stability of the topoisomerase I-DNA cleavage complex.
Molecular cancer therapeutics 2001;1(1):11-20.
2001: Tomotsugu Ichikawa; William P Petros; Susan M Ludeman; J Fangmeier; Fred H Hochberg; O Michael Colvin; E Antonio Chiocca
Intraneoplastic polymer-based delivery of cyclophosphamide for intratumoral bioconversion by a replicating oncolytic viral vector.
Cancer research 2001;61(3):864-8.
2000: GA Kong; G Anyarambhatla; William P Petros; Rod D Braun; O Michael Colvin; david needham; Mark Dewhirst
Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release.
Cancer research 2000;60(24):6950-7.
2000: Henry S Friedman; James Pluda; Jennifer A Quinn; Reginald Ewesuedo; L Long; Allan H Friedman; Ilkcan Cokgor; O Michael Colvin; Michael M Haglund; DM Ashley; Jeremy Rich; J Sampson; Anthony E Pegg; Robert C Moschel; Roger E McLendon; James M Provenzale; ES Stewart; Sandra Tourt-Uhlig; AM Garcia-Turner; James E Herndon; Darell D Bigner; M Eileen Dolan
Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(20):3522-8.
2000: David J Adams; Mark Dewhirst; James L Flowers; Michael P Gamcsik; O Michael Colvin; Govindarajan Manikumar; Mansukh C Wani; Monroe E Wall
Camptothecin analogues with enhanced antitumor activity at acidic pH.
Cancer chemotherapy and pharmacology 2000;46(4):263-71.
2000: James L Flowers; Susan M Ludeman; Michael P Gamcsik; O Michael Colvin; K L Shao; J H Boal; James B Springer; David J Adams
Evidence for a role of chloroethylaziridine in the cytotoxicity of cyclophosphamide.
Cancer chemotherapy and pharmacology 2000;45(4):335-44.
1999: Darrel P Cohen; David J Adams; James L Flowers; Monroe E Wall; Mansukh C Wani; Govindarajan Manikumar; O Michael Colvin; R Silber
Pre-clinical evaluation of SN-38 and novel camptothecin analogs against human chronic B-cell lymphocytic leukemia lymphocytes.
Leukemia research 1999;23(11):1061-70.
1999: Robert W Storms; A P Trujillo; James B Springer; L Shah; O Michael Colvin; Susan M Ludeman; Clay Smith
Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(16):9118-23.
1999: Henry S Friedman; William P Petros; Allan H Friedman; Larry J Schaaf; T Kerby; J Lawyer; M Parry; Peter J Houghton; S Lovell; Karima Rasheed; T Cloughsey; ES Stewart; O Michael Colvin; James M Provenzale; Roger E McLendon; Darell D Bigner; Ilkcan Cokgor; Michael M Haglund; Jeremy Rich; David Ashley; J Malczyn; Gary L Elfring; Langdon L Miller
Irinotecan therapy in adults with recurrent or progressive malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(5):1516-25.
1999: William P Petros; O Michael Colvin
Metabolic jeopardy with high-dose cyclophosphamide?--not so fast.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(4):723-4.
1999: Gary E Archer; John H Sampson; Roger E McLendon; Allan H Friedman; O Michael Colvin; M Rose; Howard Sands; W McCullough; Herbert E Fuchs; Darell D Bigner; Henry S Friedman
Intrathecal busulfan treatment of human neoplastic meningitis in athymic nude rats.
Journal of neuro-oncology 1999;44(3):233-41.
1999: Henry S Friedman; Anthony E Pegg; Stewart P Johnson; Natalia A Loktionova; M Eileen Dolan; Paul Modrich; Robert C Moschel; Robert F Struck; T P Brent; Susan M Ludeman; Nancy S Bullock; C Kilborn; Stephen T Keir; Q Dong; Darell D Bigner; O Michael Colvin
Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.
Cancer chemotherapy and pharmacology 1999;43(1):80-5.
1999: Q Dong; Stewart P Johnson; O Michael Colvin; Nancy S Bullock; C Kilborn; G Runyon; D M Sullivan; J Easton; Darell D Bigner; Rita Nahta; J Marks; Paul Modrich; Henry S Friedman
Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR).
Cancer chemotherapy and pharmacology 1999;43(1):73-9.
1998: Henry S Friedman; Roger E McLendon; T Kerby; M Dugan; Sandra H Bigner; A J Henry; DM Ashley; J Krischer; S Lovell; Karima Rasheed; F Marchev; A J Seman; Ilkcan Cokgor; Jeremy Rich; E Stewart; O Michael Colvin; James M Provenzale; Darell D Bigner; Michael M Haglund; Allan H Friedman; Paul Modrich
DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(12):3851-7.
1998: E M Shulman-Roskes; D A Noe; Michael P Gamcsik; A L Marlow; John Hilton; FREDERICK HAUSHEER; O Michael Colvin; Susan M Ludeman
The partitioning of phosphoramide mustard and its aziridinium ions among alkylation and P-N bond hydrolysis reactions.
Journal of medicinal chemistry 1998;41(4):515-29.
1998: M L Hanley; GB Elion; O Michael Colvin; Paul Modrich; Stephen T Keir; David J Adams; Darell D Bigner; Henry S Friedman
Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors.
Cancer chemotherapy and pharmacology 1998;42(6):479-82.
1998: C A Coggins; GB Elion; Peter J Houghton; CB Hare; Stephen T Keir; O Michael Colvin; Darell D Bigner; Henry S Friedman
Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents.
Cancer chemotherapy and pharmacology 1998;41(6):485-90.
1997: Henry S Friedman; Stewart P Johnson; Q Dong; S Clifford Schold; B K Ahmed Rasheed; Sandra H Bigner; Francis Ali-Osman; E Dolan; O Michael Colvin; P Houghton; G Germain; JT Drummond; Stephen T Keir; SL Marcelli; Darell D Bigner; Paul Modrich
Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft.
Cancer research 1997;57(14):2933-6.
1997: CB Hare; GB Elion; O Michael Colvin; Francis Ali-Osman; O W Griffith; William P Petros; Stephen T Keir; SL Marcelli; Darell D Bigner; Henry S Friedman
Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft.
Cancer chemotherapy and pharmacology 1997;40(5):409-14.
1996: L W Anderson; T L Chen; O Michael Colvin; Louise B. Grochow; Jerry M Collins; M J Kennedy; John M Strong
Cyclophosphamide and 4-Hydroxycyclophosphamide/aldophosphamide kinetics in patients receiving high-dose cyclophosphamide chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(9):1481-7.
1996: Richard J Jones; Michael I Collector; Jamie P Barber; Milada S Vala; Mary Jo Fackler; W S May; Constance A Griffin; Anita L Hawkins; B A Zehnbauer; John Hilton; O Michael Colvin; Saul J Sharkis
Characterization of mouse lymphohematopoietic stem cells lacking spleen colony-forming activity.
Blood 1996;88(2):487-91.
1996: G McCowage; R Tien; Roger E McLendon; G Felsberg; Herbert Fuchs; M L Graham; Joanne Kurtzberg; Albert Moghrabi; L Ferrell; T Kerby; M Duncan-Brown; E Stewart; Patricia L Robertson; O Michael Colvin; B Golembe; Darell D Bigner; Henry S Friedman
Successful treatment of childhood pilocytic astrocytomas metastatic to the leptomeninges with high-dose cyclophosphamide.
Medical and pediatric oncology 1996;27(1):32-9.
1996: DM Ashley; DC Longee; R Tien; Herbert Fuchs; M L Graham; Joanne Kurtzberg; J Casey; J Olson; L Meier; L Ferrell; T Kerby; M Duncan-Brown; E Stewart; O Michael Colvin; J M Pipas; G McCowage; Roger E McLendon; Darell D Bigner; Henry S Friedman
Treatment of patients with pineoblastoma with high dose cyclophosphamide.
Medical and pediatric oncology 1996;26(6):387-92.
1996: Q Dong; Nancy S Bullock; Francis Ali-Osman; O Michael Colvin; Darell D Bigner; Henry S Friedman
Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines.
Cancer chemotherapy and pharmacology 1996;37(3):242-46.
1995: Q Dong; Daniel Barsky; Michael E Colvin; C F Melius; Susan M Ludeman; J F Moravek; O Michael Colvin; Darell D Bigner; Paul Modrich; Henry S Friedman
A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5'-d(GAC).
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12170-4.
1995: Jon D Weingart; R C Thompson; Betty M. Tyler; O Michael Colvin; Henry Brem
Local delivery of the topoisomerase I inhibitor camptothecin sodium prolongs survival in the rat intracranial 9L gliosarcoma model.
International journal of cancer. Journal international du cancer 1995;62(5):605-9.
1995: Albert Moghrabi; Herbert Fuchs; M Brown; S Clifford Schold; M Graham; Joanne Kurtzberg; R Tien; G Felsberg; D H Lachance; O Michael Colvin
Cyclophosphamide in combination with sargramostim for treatment of recurrent medulloblastoma.
Medical and pediatric oncology 1995;25(3):190-6.
1995: K K Millis; Michael E Colvin; E M Shulman-Roskes; Susan M Ludeman; O Michael Colvin; Michael P Gamcsik
Comparison of the protonation of isophosphoramide mustard and phosphoramide mustard.
Journal of medicinal chemistry 1995;38(12):2166-75.
1995: L W Anderson; Susan M Ludeman; O Michael Colvin; Louise B. Grochow; John M Strong
Quantitation of 4-hydroxycyclophosphamide/aldophosphamide in whole blood.
Journal of chromatography. B, Biomedical applications 1995;667(2):247-57.
1995: Michael P Gamcsik; K K Millis; O Michael Colvin
Noninvasive detection of elevated glutathione levels in MCF-7 cells resistant to 4-hydroperoxycyclophosphamide.
Cancer research 1995;55(10):2012-6.
1995: Richard J Jones; Jamie P Barber; Milada S Vala; Michael I Collector; Scott H Kaufmann; S M Ludeman; O Michael Colvin; John Hilton
Assessment of aldehyde dehydrogenase in viable cells.
Blood 1995;85(10):2742-6.
1995: M J Kennedy; Deborah K Armstrong; A M Huelskamp; K Ohly; B V Clarke; O Michael Colvin; Louise B. Grochow; Tian Ling Chen; Nancy E Davidson
Phase I and pharmacologic study of the alkylating agent modulator novobiocin in combination with high-dose chemotherapy for the treatment of metastatic breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(5):1136-43.
1995: R T Streeper; Robert J Cotter; M E Colvin; John Hilton; O Michael Colvin
Molecular pharmacology of hepsulfam, NSC 3296801: identification of alkylated nucleosides, alkylation site, and site of DNA cross-linking.
Cancer research 1995;55(7):1491-8.
1995: D H Lachance; D Oette; S Clifford Schold; M Brown; Joanne Kurtzberg; M L Graham; R Tien; G Felsberg; O Michael Colvin; Albert Moghrabi
Dose escalation trial of cyclophosphamide with Sargramostim in the treatment of central nervous system (CNS) neoplasms.
Medical and pediatric oncology 1995;24(4):241-7.
1995: Susan M Ludeman; E M Shulman-Roskes; K K Wong; S Y Han; L W Anderson; John M Strong; O Michael Colvin
Oxime derivatives of the intermediary oncostatic metabolites of cyclophosphamide and ifosfamide: synthesis and deuterium labeling for applications to metabolite quantification.
Journal of pharmaceutical sciences 1995;84(4):393-8.
1995: K D Judy; Alessandro Olivi; K G Buahin; A Domb; Jonathan I Epstein; O Michael Colvin; Henry Brem
Effectiveness of controlled release of a cyclophosphamide derivative with polymers against rat gliomas.
Journal of neurosurgery 1995;82(3):481-6.
1995: Tian Ling Chen; J L Passos-Coelho; D A Noe; M J Kennedy; K C Black; O Michael Colvin; Louise B. Grochow
Nonlinear pharmacokinetics of cyclophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation.
Cancer research 1995;55(4):810-6.
1995: Jeremy Rich; GB Elion; D Wellner; O Michael Colvin; Dennis R Groothuis; John Hilton; Kurt Schlageter; D D Bigner; O W Griffith; H S Friedman
The effect of L-amino acid oxidase on activity of melphalan against an intracranial xenograft.
Cancer chemotherapy and pharmacology 1995;36(5):379-84.
1994: Henry S Friedman; Gary E Archer; Roger E McLendon; J M Schuster; O Michael Colvin; A Guaspari; R Blum; P A Savina; Herbert E Fuchs; Darell D Bigner
Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats.
Cancer research 1994;54(17):4710-4.
1994: Henry S Friedman; M Eileen Dolan; Scott H Kaufmann; O Michael Colvin; O W Griffith; Robert C Moschel; S Clifford Schold; Darell D Bigner; Francis Ali-Osman
Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
Cancer research 1994;54(13):3487-93.
1994: K A Walter; Mitchell A Cahan; A Gur; Betty M. Tyler; John Hilton; O Michael Colvin; Peter C Burger; A Domb; Henry Brem
Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma.
Cancer research 1994;54(8):2207-12.
1994: W Dang; O Michael Colvin; Henry Brem; W Mark Saltzman
Covalent coupling of methotrexate to dextran enhances the penetration of cytotoxicity into a tissue-like matrix.
Cancer research 1994;54(7):1729-35.
1994: Tian Ling Chen; M J Kennedy; V M Dunlap; O Michael Colvin
Determination of plasma novobiocin levels by a reversed-phase high-performance liquid chromatographic assay.
Journal of chromatography 1994;652(1):109-13.
1994: R H Aaron; GB Elion; O Michael Colvin; M Graham; Stephen T Keir; Darell D Bigner; Henry S Friedman
Busulfan therapy of central nervous system xenografts in athymic mice.
Cancer chemotherapy and pharmacology 1994;35(2):127-31.
1994: Mitchell A Cahan; K A Walter; O Michael Colvin; Henry Brem
Cytotoxicity of taxol in vitro against human and rat malignant brain tumors.
Cancer chemotherapy and pharmacology 1994;33(5):441-4.
1993: M I Mahmoud; James J Potter; O Michael Colvin; John Hilton; Esteban Mezey
Effect of 4-(diethylamino)benzaldehyde on ethanol metabolism in mice.
Alcoholism, clinical and experimental research 1993;17(6):1223-7.
1993: Michael P Gamcsik; Susan M Ludeman; E M Shulman-Roskes; I J McLennan; Michael E Colvin; O Michael Colvin
Protonation of phosphoramide mustard and other phosphoramides.
Journal of medicinal chemistry 1993;36(23):3636-45.
1993: M G Bolton; John Hilton; Keith D Robertson; R T Streeper; O Michael Colvin; D A Noe
Kinetic analysis of the reaction of melphalan with water, phosphate, and glutathione.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(6):986-96.
1993: J M Schuster; Henry S Friedman; Gary E Archer; Herbert E Fuchs; Roger E McLendon; O Michael Colvin; Darell D Bigner
Intraarterial therapy of human glioma xenografts in athymic rats using 4-hydroperoxycyclophosphamide.
Cancer research 1993;53(10 Suppl):2338-43.
1993: O Michael Colvin; H S Friedman; M P Gamcsik; Catherine Fenselau; John Hilton
Role of glutathione in cellular resistance to alkylating agents.
Advances in enzyme regulation 1993;33():19-26.
1992: P C Phillips; T T Than; L C Cork; John Hilton; Benjamin S Carson; O Michael Colvin; Louise B. Grochow
Intrathecal 4-hydroperoxycyclophosphamide: neurotoxicity, cerebrospinal fluid pharmacokinetics, and antitumor activity in a rabbit model of VX2 leptomeningeal carcinomatosis.
Cancer research 1992;52(22):6168-74.
1992: Dennis R Groothuis; B E Lippitz; I Fekete; Kurt Schlageter; P Molnar; O Michael Colvin; C R Roe; D D Bigner; H S Friedman
The effect of an amino acid-lowering diet on the rate of melphalan entry into brain and xenotransplanted glioma.
Cancer research 1992;52(20):5590-6.
1992: Henry S Friedman; O Michael Colvin; Scott H Kaufmann; Susan M Ludeman; Nancy S Bullock; Darell D Bigner; O W Griffith
Cyclophosphamide resistance in medulloblastoma.
Cancer research 1992;52(19):5373-8.
1992: M Krenn; Michael P Gamcsik; Georgia B Vogelsang; O Michael Colvin; Kam W Leong
Improvements in solubility and stability of thalidomide upon complexation with hydroxypropyl-beta-cyclodextrin.
Journal of pharmaceutical sciences 1992;81(7):685-9.
1992: Georgia B Vogelsang; Evan Farmer; Allan Hess; V Altamonte; W E Beschorner; D A Jabs; RUSSELL CORIO; L S Levin; O Michael Colvin; John R Wingard
Thalidomide for the treatment of chronic graft-versus-host disease.
The New England journal of medicine 1992;326(16):1055-8.
1992: Stuart A Grossman; C Reinhard; O Michael Colvin; M Chasin; R Brundrett; Rafael J Tamargo; Henry Brem
The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers.
Journal of neurosurgery 1992;76(4):640-7.
1992: Deborah K Armstrong; G B Gordon; John Hilton; R T Streeper; O Michael Colvin; Nancy E Davidson
Hepsulfam sensitivity in human breast cancer cell lines: the role of glutathione and glutathione S-transferase in resistance.
Cancer research 1992;52(6):1416-21.
1991: M W Nabors; Constance A Griffin; B A Zehnbauer; Ralph Hruban; P C Phillips; Stuart A Grossman; Henry Brem; O Michael Colvin
Multidrug resistance gene (MDR1) expression in human brain tumors.
Journal of neurosurgery 1991;75(6):941-6.
1991: A I Radin; X L Zhoa; T H Woo; O Michael Colvin; John Hilton
Structure and expression of the cytosolic aldehyde dehydrogenase gene in cyclophosphamide-resistant murine leukemia L1210 cells.
Biochemical pharmacology 1991;42(10):1933-9.
1990: Tian Ling Chen; Paul S Miller; P O Ts'o; O Michael Colvin; T L Chem
Disposition and metabolism of oligodeoxynucleoside methylphosphonate following a single i.v. injection in mice.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(5):815-8.
1990: Michael B Kastan; E Schlaffer; J E Russo; O Michael Colvin; Curt I Civin; John Hilton
Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells.
Blood 1990;75(10):1947-50.
1990: FREDERICK HAUSHEER; U C Singh; J D Saxe; O Michael Colvin; P O T'su
Can oligonucleoside methylphosphonates form a stable triplet with a double DNA helix?
Anti-cancer drug design 1990;5(2):159-67.
1990: Richard J Jones; Carole B Miller; B A Zehnbauer; S D Rowley; O Michael Colvin; L L Sensenbrenner
In vitro evaluation of combination drug purging for autologous bone marrow transplantation.
Bone marrow transplantation 1990;5(5):301-7.
1990: Zhi-Min Yuan; Catherine Fenselau; D M Dulik; W Martin; W B Emary; R B Brundrett; O Michael Colvin; Robert J Cotter
Laser desorption electron impact: application to a study of the mechanism of conjugation of glutathione and cyclophosphamide.
Analytical chemistry 1990;62(8):868-70.
1990: Henry S Friedman; O Michael Colvin; K Aisaka; J Popp; E H Bossen; K A Reimer; J B Powell; John Hilton; S S Gross; R Levi
Glutathione protects cardiac and skeletal muscle from cyclophosphamide-induced toxicity.
Cancer research 1990;50(8):2455-62.
1990: Herbert E Fuchs; Gary E Archer; O Michael Colvin; Sandra H Bigner; J M Schuster; G N Fuller; L H Muhlbaier; S Clifford Schold; Henry S Friedman; Darell D Bigner
Activity of intrathecal 4-hydroperoxycyclophosphamide in a nude rat model of human neoplastic meningitis.
Cancer research 1990;50(6):1954-9.
1990: B E Lippitz; Edward C Halperin; O W Griffith; O Michael Colvin; G Honore; C B Ostertag; Darell D Bigner; Henry S Friedman
L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice.
Neurosurgery 1990;26(2):255-60.
1990: E R Lilley; M C Rosenberg; GB Elion; O Michael Colvin; Darell D Bigner; Henry S Friedman
Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft.
Cancer research 1990;50(2):284-7.
1989: M C Rosenberg; O Michael Colvin; O W Griffith; Sandra H Bigner; GB Elion; J K Horton; E Lilley; Darell D Bigner; Henry S Friedman
Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion.
Cancer research 1989;49(24 Pt 1):6917-22.
1989: FREDERICK HAUSHEER; U C Singh; J D Saxe; O Michael Colvin
Identification of local determinants of DNA interstrand crosslink formation by cyclophosphamide metabolites.
Anti-cancer drug design 1989;4(4):281-94.
1989: Henry S Friedman; S Clifford Schold; M S Mahaley; O Michael Colvin; W Jerry Oakes; N A Vick; Peter C Burger; Sandra H Bigner; Michael J Borowitz; Edward C Halperin
Phase II treatment of medulloblastoma and pineoblastoma with melphalan: clinical therapy based on experimental models of human medulloblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(7):904-11.
1989: S D Rowley; Richard J Jones; Steven Piantadosi; Hayden Braine; O Michael Colvin; JANICE DAVIS SPROUL; R Saral; Saul J Sharkis; John R Wingard; A M Yeager
Efficacy of ex vivo purging for autologous bone marrow transplantation in the treatment of acute nonlymphoblastic leukemia.
Blood 1989;74(1):501-6.
1989: T L Chen; Georgia B Vogelsang; Brent G Petty; R B Brundrett; D A Noe; G W Santos; O Michael Colvin
Plasma pharmacokinetics and urinary excretion of thalidomide after oral dosing in healthy male volunteers.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(4):402-5.
1989: FREDERICK HAUSHEER; S N Rao; Michael P Gamcsik; P A Kollman; O Michael Colvin; J D Saxe; Barry D Nelkin; I J McLennan; G Barnett; Stephen B Baylin
Computational analysis of structural and energetic consequences of DNA methylation.
Carcinogenesis 1989;10(6):1131-7.
1989: Henry S Friedman; O Michael Colvin; O W Griffith; B Lippitz; GB Elion; S Clifford Schold; John Hilton; Darell D Bigner
Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion.
Journal of the National Cancer Institute 1989;81(7):524-7.
1989: J E Russo; John Hilton; O Michael Colvin
The role of aldehyde dehydrogenase isozymes in cellular resistance to the alkylating agent cyclophosphamide.
Progress in clinical and biological research 1989;290():65-79.
1989: Louise B. Grochow; Richard J Jones; R B Brundrett; Hayden Braine; Tian Ling Chen; R Saral; G W Santos; O Michael Colvin
Pharmacokinetics of busulfan: correlation with veno-occlusive disease in patients undergoing bone marrow transplantation.
Cancer chemotherapy and pharmacology 1989;25(1):55-61.
1988: Stephen Xavier Skapek; O Michael Colvin; O W Griffith; D R Groothuis; E V Colapinto; Y Lee; John Hilton; GB Elion; Darell D Bigner; Henry S Friedman
Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts.
Biochemical pharmacology 1988;37(22):4313-7.
1988: Henry S Friedman; Stephen Xavier Skapek; O Michael Colvin; GB Elion; M R Blum; P M Savina; John Hilton; S Clifford Schold; Joanne Kurtzberg; Darell D Bigner
Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma.
Cancer research 1988;48(19):5397-402.
1988: Henry S Friedman; O Michael Colvin; Stephen Xavier Skapek; Susan M Ludeman; GB Elion; S Clifford Schold; P F Jacobsen; L H Muhlbaier; Darell D Bigner
Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents.
Cancer research 1988;48(15):4189-95.
1988: Richard J Jones; O Michael Colvin; L L Sensenbrenner
Prediction of the ability to purge tumor from murine bone marrow using clonogenic assays.
Cancer research 1988;48(12):3394-7.
1988: Stephen Xavier Skapek; O Michael Colvin; O W Griffith; GB Elion; Darell D Bigner; Henry S Friedman
Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice.
Cancer research 1988;48(10):2764-7.
1987: Richard J Jones; M Zuehlsdorf; S D Rowley; John Hilton; G W Santos; L L Sensenbrenner; O Michael Colvin
Variability in 4-hydroperoxycyclophosphamide activity during clinical purging for autologous bone marrow transplantation.
Blood 1987;70(5):1490-4.
1987: Richard J Jones; Saul J Sharkis; P Celano; O Michael Colvin; S D Rowley; L L Sensenbrenner
Progenitor cell assays predict hematopoietic reconstitution after syngeneic transplantation in mice.
Blood 1987;70(4):1186-92.