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Roger Cone

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Brandon L Panaro; Roger D Cone
Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods.
Benjamin J Renquist; Kate L J Ellacott; Robert F Klein; Emily A Larson; Jonathan G Murphy; Dawn Olsen; Roger D Cone
Melanocortin-3 receptor regulates the normal fasting response.
Ida J Hatoum; Kasia Blaszczyk; Kelli L Boyd; Roger D Cone; Kate L J Ellacott; I Sadaf Farooqi; Julia M Keogh; Lian Li Ma; Nicholas Stylopoulos; Amanda M Vanhoose; Deng-Ping Yin; Lee M Kaplan
Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery.

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All Publications

2013: Brandon L Panaro; Roger D Cone
Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(17):7050-5.
2012: Benjamin J Renquist; Kate L J Ellacott; Robert F Klein; Emily A Larson; Jonathan G Murphy; Dawn Olsen; Roger D Cone
Melanocortin-3 receptor regulates the normal fasting response.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(23):E1489-98.
2012: Ida J Hatoum; Kasia Blaszczyk; Kelli L Boyd; Roger D Cone; Kate L J Ellacott; I Sadaf Farooqi; Julia M Keogh; Lian Li Ma; Nicholas Stylopoulos; Amanda M Vanhoose; Deng-Ping Yin; Lee M Kaplan
Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery.
The Journal of clinical endocrinology and metabolism 2012;97(6):E1023-31.
2012: Chao Zhang; Paul M Forlano; Roger D Cone
AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost.
Cell metabolism 2012;15(2):256-64.
2011: Roger D Cone; Richard B Simerly
Leptin grows up and gets a neural network.
Neuron 2011;71(1):4-6.
2011: Savannah Williams; Savannah Y Williams; Dehui Mi; Julien Sebag; Jackie D Corbin; C David Weaver; Roger D Cone
Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.
European journal of pharmacology 2011;660(1):139-47.
2011: Benjamin J Renquist; Rachel N Lippert; Julien A Sebag; Kate L J Ellacott; Roger D Cone
Physiological roles of the melanocortin MC₃ receptor.
European journal of pharmacology 2011;660(1):13-20.
2011: Masoud Ghamari-Langroudi; Roger D Cone
Shining a light on energy homeostasis.
Cell metabolism 2011;13(3):235-6.
2011: Dollada Srisai; Matthew P Gillum; Brandon L Panaro; Xian-Man Zhang; Naiphinich Kotchabhakdi; Gerald I Shulman; Kate L J Ellacott; Roger D Cone
Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse.
Endocrinology 2011;152(3):890-902.
2011: Masoud Ghamari-Langroudi; Dollada Srisai; Roger D Cone
Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):355-60.
2010: Masoud Ghamari-Langroudi; Kristen R Vella; Dollada Srisai; Michelle L Sugrue; Anthony N Hollenberg; Roger D Cone
Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity.
Molecular endocrinology (Baltimore, Md.) 2010;24(12):2366-81.
2009: Kenneth A Gruber; Wei Fan; Helena Åkerberg; Dan Larhammar; Melissa J S Chee; William F Colmers; Roger D Cone
Neuropeptide Y and gamma-melanocyte stimulating hormone (gamma-MSH) share a common pressor mechanism of action.
Endocrine 2009;35(3):312-24.
2008: Gregory M Sutton; Diego Perez-Tilve; Ruben Nogueiras; Jidong Fang; Jason K Kim; Roger D Cone; Jeffrey M Gimble; Matthias H Tschöp; Andrew A Butler
The melanocortin-3 receptor is required for entrainment to meal intake.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(48):12946-55.
2007: Kate L J Ellacott; Jonathan Murphy; Daniel L Marks; Roger D Cone
Obesity-induced inflammation in white adipose tissue is attenuated by loss of melanocortin-3 receptor signaling.
Endocrinology 2007;148(12):6186-94.
2007: Paul M Forlano; Roger D Cone
Conserved neurochemical pathways involved in hypothalamic control of energy homeostasis.
The Journal of comparative neurology 2007;505(3):235-48.
2007: Youngsup Song; Roger D Cone
Creation of a genetic model of obesity in a teleost.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(9):2042-9.
2007: Adriana Voss-Andreae; Jonathan Murphy; Kate L J Ellacott; Ronald C Stuart; Eduardo A Nillni; Roger D Cone; Wei Fan
Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue.
Endocrinology 2007;148(4):1550-60.
2006: Roger D Cone
Studies on the physiological functions of the melanocortin system.
Endocrine reviews 2006;27(7):736-49.
2006: Xi-Ping Ni; Andrew A Butler; Roger D Cone; Michael H Humphreys
Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones.
Journal of hypertension 2006;24(11):2239-46.
2006: Robert H Mak; Wai Cheung; Roger D Cone; Daniel L Marks
Mechanisms of disease: Cytokine and adipokine signaling in uremic cachexia.
Nature clinical practice. Nephrology 2006;2(9):527-34.
2006: Kate L J Ellacott; Roger D Cone
The role of the central melanocortin system in the regulation of food intake and energy homeostasis: lessons from mouse models.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006;361(1471):1265-74.
2006: Kate L J Ellacott; Ilia G Halatchev; Roger D Cone
Characterization of leptin-responsive neurons in the caudal brainstem.
Endocrinology 2006;147(7):3190-5.
2006: Robert H Mak; Wai Cheung; Roger D Cone; Daniel L Marks
Leptin and inflammation-associated cachexia in chronic kidney disease.
Kidney international 2006;69(5):794-7.
2006: Caurnel Morgan; Roger D Cone
Melanocortin-5 receptor deficiency in mice blocks a novel pathway influencing pheromone-induced aggression.
Behavior genetics 2006;36(2):291-300.
2006: Kate L J Ellacott; Ilia G Halatchev; Roger D Cone
Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis.
Peptides 2006;27(2):340-9.
2006: Daniel L Marks; Victor Hruby; Gregor Brookhart; Roger D Cone
The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R).
Peptides 2006;27(2):259-64.
2005: Masoud Ghamari-Langroudi; William F Colmers; Roger D Cone
PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors.
Cell metabolism 2005;2(3):191-9.
2005: Wai Cheung; Pin X Yu; Brian M Little; Roger D Cone; Daniel L Marks; Robert H Mak
Role of leptin and melanocortin signaling in uremia-associated cachexia.
The Journal of clinical investigation 2005;115(6):1659-65.
2005: Roger D Cone
Anatomy and regulation of the central melanocortin system.
Nature neuroscience 2005;8(5):571-8.
2005: Ilia G Halatchev; Roger D Cone
Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice.
Cell metabolism 2005;1(3):159-68.
2005: Robert H Mak; Wai Cheung; Roger D Cone; Daniel L Marks
Orexigenic and anorexigenic mechanisms in the control of nutrition in chronic kidney disease.
Pediatric nephrology (Berlin, Germany) 2005;20(3):427-31.
2005: Kanji A Takahashi; Roger D Cone
Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons.
Endocrinology 2005;146(3):1043-7.
2004: Csaba Fekete; Daniel L Marks; Sumit Sarkar; Charles H Emerson; William M Rand; Roger D Cone; Ronald M Lechan
Effect of Agouti-related protein in regulation of the hypothalamic-pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse.
Endocrinology 2004;145(11):4816-21.
2004: Ilia G Halatchev; Kate L J Ellacott; Wei Fan; Roger D Cone
Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism.
Endocrinology 2004;145(6):2585-90.
2004: Daniel L Marks; Nathalie Boucher; Christian-Marc Lanouette; Louis Pérusse; Gregor Brookhart; Anthony G Comuzzie; Yvon C Chagnon; Roger D Cone
Ala67Thr polymorphism in the Agouti-related peptide gene is associated with inherited leanness in humans.
American journal of medical genetics. Part A 2004;126A(3):267-71.
2004: Wei Fan; Kate L J Ellacott; Ilia G Halatchev; Kanji Takahashi; Pinxuan Yu; Roger D Cone
Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system.
Nature neuroscience 2004;7(4):335-6.
2004: David Cepoi; Teresa Phillips; Mary J Cismowski; Val S Goodfellow; Nicholas Ling; Roger D Cone; Wei Fan
Assessment of a small molecule melanocortin-4 receptor-specific agonist on energy homeostasis.
Brain research 2004;1000(1-2):64-71.
2004: Guoxia Han; Carrie Haskell-Luevano; Laura Kendall; Gregg Bonner; Mac E Hadley; Roger D Cone; Victor J Hruby
De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach.
Journal of medicinal chemistry 2004;47(6):1514-26.
2004: Caurnel Morgan; Ruth E Thomas; Weidong Ma; Milos V Novotny; Roger D Cone
Melanocortin-5 receptor deficiency reduces a pheromonal signal for aggression in male mice.
Chemical senses 2004;29(2):111-5.
2004: Kate L J Ellacott; Roger D Cone
The central melanocortin system and the integration of short- and long-term regulators of energy homeostasis.
Recent progress in hormone research 2004;59():395-408.
2004: Caurnel Morgan; Ruth E Thomas; Roger D Cone
Melanocortin-5 receptor deficiency promotes defensive behavior in male mice.
Hormones and behavior 2004;45(1):58-63.
2004: Kanji A Takahashi; James L Smart; Hongyan Liu; Roger D Cone
The anorexigenic fatty acid synthase inhibitor, C75, is a nonspecific neuronal activator.
Endocrinology 2004;145(1):184-93.
2003: Andrea M Haqq; Patricia René; Toshiro Kishi; Kathy Khong; Charlotte E Lee; Hongyan Liu; Jeffrey M Friedman; Joel K Elmquist; Roger D Cone
Characterization of a novel binding partner of the melanocortin-4 receptor: attractin-like protein.
The Biochemical journal 2003;376(Pt 3):595-605.
2003: Youngsup Song; Gregory Golling; Theresa L Thacker; Roger D Cone
Agouti-related protein (AGRP) is conserved and regulated by metabolic state in the zebrafish, Danio rerio.
Endocrine 2003;22(3):257-65.
2003: Caurnel Morgan; Henryk F Urbanski; Wei Fan; Huda Akil; Roger D Cone
Pheromone-induced anorexia in male Syrian hamsters.
American journal of physiology. Endocrinology and metabolism 2003;285(5):E1028-38.
2003: Baoji Xu; Evan H Goulding; Keling Zang; David Cepoi; Roger D Cone; Kevin R Jones; Laurence H Tecott; Louis F Reichardt
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor.
Nature neuroscience 2003;6(7):736-42.
2003: Daniel L Marks; Roger D Cone
The role of the melanocortin-3 receptor in cachexia.
Annals of the New York Academy of Sciences 2003;994():258-66.
2003: Andrew A Butler; Roger D Cone
Knockout studies defining different roles for melanocortin receptors in energy homeostasis.
Annals of the New York Academy of Sciences 2003;994():240-5.
2003: Michael Alexander cowley; Roger D Cone; Pablo J Enriori; Ingrid Louiselle; Sarah M Williams; Anne E Evans
Electrophysiological actions of peripheral hormones on melanocortin neurons.
Annals of the New York Academy of Sciences 2003;994():175-86.
2003: Lora K Heisler; Michael Alexander cowley; Toshiro Kishi; Laurence H Tecott; Wei Fan; Malcolm J Low; James L Smart; Marcelo Rubinstein; Jeffrey B Tatro; Jeffrey M Zigman; Roger D Cone; Joel K Elmquist
Central serotonin and melanocortin pathways regulating energy homeostasis.
Annals of the New York Academy of Sciences 2003;994():169-74.
2003: Suzanne M Appleyard; Michael Hayward; Juan I Young; Andrew A Butler; Roger D Cone; Marcelo Rubinstein; Malcolm J Low
A role for the endogenous opioid beta-endorphin in energy homeostasis.
Endocrinology 2003;144(5):1753-60.
2003: Xi-Ping Ni; David Pearce; Andrew A Butler; Roger D Cone; Michael H Humphreys
Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse.
The Journal of clinical investigation 2003;111(8):1251-8.
2003: Daniel L Marks; Andrew A Butler; Renn Turner; Gregor Brookhart; Roger D Cone
Differential role of melanocortin receptor subtypes in cachexia.
Endocrinology 2003;144(4):1513-23.
2003: Michael Alexander cowley; Roy G Smith; Sabrina Diano; Matthias H Tschöp; Nina Pronchuk; Kevin L Grove; Christian J Strasburger; Martin Bidlingmaier; Michael Esterman; Mark L Heiman; Luis M Garcia-Segura; Eduardo A Nillni; Pablo Mendez; Malcolm J Low; Peter Sotonyi; Jeffrey M Friedman; Hongyan Liu; Shirly Pinto; William F Colmers; Roger D Cone; Tamas L Horvath
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis.
Neuron 2003;37(4):649-61.
2002: Rachel L Batterham; Michael Alexander cowley; Caroline J Small; Herbert Herzog; Mark A Cohen; Catherine L Dakin; Alison M Wren; Audrey E Brynes; Malcolm J Low; Mohammad A Ghatei; Roger D Cone; Stephen R Bloom
Gut hormone PYY(3-36) physiologically inhibits food intake.
Nature 2002;418(6898):650-4.
2002: Lora K Heisler; Michael Alexander cowley; Laurence H Tecott; Wei Fan; Malcolm J Low; James L Smart; Marcelo Rubinstein; Jeffrey B Tatro; Jacob N Marcus; Henne Holstege; Charlotte E Lee; Roger D Cone; Joel K Elmquist
Activation of central melanocortin pathways by fenfluramine.
Science (New York, N.Y.) 2002;297(5581):609-11.
2002: Andrew A Butler; Roger D Cone
The melanocortin receptors: lessons from knockout models.
Neuropeptides 2002;36(2-3):77-84.
2002: Daniel L Marks; Andrew A Butler; Roger D Cone
Melanocortin pathway: animal models of obesity and disease.
Annales d'endocrinologie 2002;63(2 Pt 1):121-4.
2001: Roger D Cone; Michael Alexander cowley; Andrew A Butler; Wei Fan; Daniel L Marks; Malcolm J Low
The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25 Suppl 5():S63-7.
2001: Andrew A Butler; Roger D Cone
Knockout models resulting in the development of obesity.
Trends in genetics : TIG 2001;17(10):S50-4.
2001: Kathy Khong; S E Kurtz; R L Sykes; Roger D Cone
Expression of functional melanocortin-4 receptor in the hypothalamic GT1-1 cell line.
Neuroendocrinology 2001;74(3):193-201.
2001: Andrew A Butler; Daniel L Marks; Wei Fan; C M Kuhn; M Bartolome; Roger D Cone
Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat.
Nature neuroscience 2001;4(6):605-11.
2001: Michael Alexander cowley; J L Smart; M Rubinstein; M G Cerdán; Sabrina Diano; T L Horvath; Roger D Cone; Malcolm J Low
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus.
Nature 2001;411(6836):480-4.
2001: Daniel L Marks; N Ling; Roger D Cone
Role of the central melanocortin system in cachexia.
Cancer research 2001;61(4):1432-8.
2001: Daniel L Marks; Roger D Cone
Central melanocortins and the regulation of weight during acute and chronic disease.
Recent progress in hormone research 2001;56():359-75.
2000: Andrew A Butler; RA Kesterson; Kathy Khong; Mary Jane Cullen; Mary Ann Pelleymounter; J Dekoning; M Baetscher; Roger D Cone
A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse.
Endocrinology 2000;141(9):3518-21.
2000: Wei Fan; Daniela M Dinulescu; Andrew A Butler; J Zhou; Daniel L Marks; Roger D Cone
The central melanocortin system can directly regulate serum insulin levels.
Endocrinology 2000;141(9):3072-9.
2000: J De Souza; Andrew A Butler; Roger D Cone
Disproportionate inhibition of feeding in A(y) mice by certain stressors: a cautionary note.
Neuroendocrinology 2000;72(2):126-32.
2000: Roger D Cone
Haploinsufficiency of the melanocortin-4 receptor: part of a thrifty genotype?
The Journal of clinical investigation 2000;106(2):185-7.
2000: Daniela M Dinulescu; Roger D Cone
Agouti and agouti-related protein: analogies and contrasts.
The Journal of biological chemistry 2000;275(10):6695-8.
2000: S W Robinson; Daniela M Dinulescu; Roger D Cone
Genetic models of obesity and energy balance in the mouse.
Annual review of genetics 2000;34():687-745.
2000: C Haskell-Luevano; S Lim; W Yuan; Roger D Cone; V J Hruby
Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions.
Peptides 2000;21(1):49-57.
1999: C Haskell-Luevano; A Rosenquist; Andrew J Souers; Kathy Khong; Jonathan A Ellman; Roger D Cone
Compounds that activate the mouse melanocortin-1 receptor identified by screening a small molecule library based upon the beta-turn.
Journal of medicinal chemistry 1999;42(21):4380-7.
1999: Michael Alexander cowley; Nina Pronchuk; Wei Fan; Daniela M Dinulescu; William F Colmers; Roger D Cone
Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat.
Neuron 1999;24(1):155-63.
1999: Roger D Cone
[The central melanocortin system and its role in energy homeostasis].
Annales d'endocrinologie 1999;60(1):3-9.
1999: C Haskell-Luevano; P Chen; C Li; K Chang; M Susan Smith; Judy L Cameron; Roger D Cone
Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat.
Endocrinology 1999;140(3):1408-15.
1998: Daniela M Dinulescu; Wei Fan; Bruce Alan Boston; K McCall; M L Lamoreux; K J Moore; Jill Montagno; Roger D Cone
Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(21):12707-12.
1998: Xi-Ping Ni; RA Kesterson; S D Sharma; V J Hruby; Roger D Cone; E Wiedemann; Michael H Humphreys
Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists.
The American journal of physiology 1998;274(4 Pt 2):R931-8.
1998: D Lu; Dag Inge Våge; Roger D Cone
A ligand-mimetic model for constitutive activation of the melanocortin-1 receptor.
Molecular endocrinology (Baltimore, Md.) 1998;12(4):592-604.
1997: Wenbiao Chen; M A Kelly; X Opitz-Araya; R E Thomas; Malcolm J Low; Roger D Cone
Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides.
Cell 1997;91(6):789-98.
1997: Bruce Alan Boston; K M Blaydon; J Varnerin; Roger D Cone
Independent and additive effects of central POMC and leptin pathways on murine obesity.
Science (New York, N.Y.) 1997;278(5343):1641-4.
1997: RA Kesterson; Dennis Huszar; CA Lynch; R B Simerly; Roger D Cone
Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome.
Molecular endocrinology (Baltimore, Md.) 1997;11(5):630-7.
1997: Dennis Huszar; CA Lynch; Victoria Fairchild-Huntress; Judy H Dunmore; Q Fang; L R Berkemeier; W Gu; RA Kesterson; Bruce Alan Boston; Roger D Cone; FJ Smith; L Arthur Campfield; P Burn; F Lee
Targeted disruption of the melanocortin-4 receptor results in obesity in mice.
Cell 1997;88(1):131-41.
1997: Wei Fan; Bruce Alan Boston; RA Kesterson; V J Hruby; Roger D Cone
Role of melanocortinergic neurons in feeding and the agouti obesity syndrome.
Nature 1997;385(6612):165-8.
1997: S V Koppula; L S Robbins; D Lu; E Baack; Clifton R White; Neil A Swanson; Roger D Cone
Identification of common polymorphisms in the coding sequence of the human MSH receptor (MCIR) with possible biological effects.
Human mutation 1997;9(1):30-6.
1996: S J Li; K Varga; P Archer; Victor J Hruby; S D Sharma; RA Kesterson; Roger D Cone; George Kunos
Melanocortin antagonists define two distinct pathways of cardiovascular control by alpha- and gamma-melanocyte-stimulating hormones.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(16):5182-8.
1996: Bruce Alan Boston; Roger D Cone
Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line.
Endocrinology 1996;137(5):2043-50.
1996: Roger D Cone; D Lu; S Koppula; Dag Inge Våge; Helge Klungland; Bruce Alan Boston; Wenbiao Chen; D N Orth; C Pouton; RA Kesterson
The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation.
Recent progress in hormone research 1996;51():287-317; discussion 318.
1995: Victor J Hruby; D Lu; S D Sharma; A L Castrucci; RA Kesterson; FA al-Obeidi; Mac E Hadley; Roger D Cone
Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors.
Journal of medicinal chemistry 1995;38(18):3454-61.
1995: Peter Stenzel; RA Kesterson; W Yeung; Roger D Cone; Marvin B Rittenberg; Mary P Stenzel-Poore
Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart.
Molecular endocrinology (Baltimore, Md.) 1995;9(5):637-45.
1995: Wenbiao Chen; T S Shields; Philip J S Stork; Roger D Cone
A colorimetric assay for measuring activation of Gs- and Gq-coupled signaling pathways.
Analytical biochemistry 1995;226(2):349-54.
1995: CS Nelson; Roger D Cone; L S Robbins; Charles N Allen; John P Adelman
Cloning and expression of a 5HT7 receptor from Xenopus laevis.
Receptors & channels 1995;3(1):61-70.
1994: K G Mountjoy; M T Mortrud; Malcolm J Low; R B Simerly; Roger D Cone
Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.
Molecular endocrinology (Baltimore, Md.) 1994;8(10):1298-308.
1994: R Ellen Magenis; L Smith; J H Nadeau; K R Johnson; K G Mountjoy; Roger D Cone
Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(8):503-8.
1994: K G Mountjoy; I M Bird; William E Rainey; Roger D Cone
ACTH induces up-regulation of ACTH receptor mRNA in mouse and human adrenocortical cell lines.
Molecular and cellular endocrinology 1994;99(1):R17-20.
1993: L Roselli-Rehfuss; K G Mountjoy; L S Robbins; M T Mortrud; Malcolm J Low; Jeffrey B Tatro; M L Entwistle; R B Simerly; Roger D Cone
Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):8856-60.
1993: Roger D Cone; K G Mountjoy; L S Robbins; J H Nadeau; K R Johnson; L Roselli-Rehfuss; M T Mortrud
Cloning and functional characterization of a family of receptors for the melanotropic peptides.
Annals of the New York Academy of Sciences 1993;680():342-63.
1993: L S Robbins; J H Nadeau; K R Johnson; M A Kelly; L Roselli-Rehfuss; E Baack; K G Mountjoy; Roger D Cone
Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function.
Cell 1993;72(6):827-34.
1992: P I Woloshin; K M Walton; R P Rehfuss; Richard H Goodman; Roger D Cone
3',5'-cyclic adenosine monophosphate-regulated enhancer binding (CREB) activity is required for normal growth and differentiated phenotype in the FRTL5 thyroid follicular cell line.
Molecular endocrinology (Baltimore, Md.) 1992;6(10):1725-33.
1992: K G Mountjoy; L S Robbins; M T Mortrud; Roger D Cone
The cloning of a family of genes that encode the melanocortin receptors.
Science (New York, N.Y.) 1992;257(5074):1248-51.
1992: Daniel W Carr; R E Stofko-Hahn; I D Fraser; Roger D Cone; John D Scott
Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins. Characterization of AKAP 79.
The Journal of biological chemistry 1992;267(24):16816-23.
1992: L Roselli-Rehfuss; L S Robbins; Roger D Cone
Thyrotropin receptor messenger ribonucleic acid is expressed in most brown and white adipose tissues in the guinea pig.
Endocrinology 1992;130(4):1857-61.
1991: S Tsuzaki; Roger D Cone; A L Frazier; Alan C Moses
The interaction of signal transduction pathways in FRTL5 thyroid follicular cells: studies with stable expression of beta 2-adrenergic receptors.
Endocrinology 1991;128(3):1359-68.
1990: Q Y Zhou; David K Grandy; L Thambi; J A Kushner; Hubert H M Van Tol; Roger D Cone; D Pribnow; J Salon; James R Bunzow; Olivier Civelli
Cloning and expression of human and rat D1 dopamine receptors.
Nature 1990;347(6288):76-80.
1990: A L Frazier; L S Robbins; Philip J S Stork; Rolf Sprengel; Deborah L Segaloff; Roger D Cone
Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing.
Molecular endocrinology (Baltimore, Md.) 1990;4(8):1264-76.