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Carmen Allegra

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Mark S Roh; Linda H Colangelo; Michael J O'Connell; Greg Yothers; Melvin Deutsch; Carmen J Allegra; Morton Kahlenberg; Luis Baez-Diaz; Carol S Ursiny; Nicholas J Petrelli; Norman Wolmark
Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03.
Carmen J Allegra; Greg Yothers; Michael J O'Connell; Saima Sharif; Linda H Colangelo; Samia H Lopa; Nicholas J Petrelli; Richard M Goldberg; James N Atkins; Thomas E Seay; Louis Fehrenbacher; Seamus O'Reilly; Luis Chu; Catherine A Azar; Norman Wolmark
Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer.
George P Kim; Linda H Colangelo; Soonmyung Paik; Michael J O'Connell; Ilan R Kirsch; Carmen J Allegra; Norman Wolmark
Predictive value of microsatellite instability-high remains controversial.

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2009: Mark S Roh; Linda H Colangelo; Michael J O'Connell; Greg Yothers; Melvin Deutsch; Carmen J Allegra; Morton Kahlenberg; Luis Baez-Diaz; Carol S Ursiny; Nicholas J Petrelli; Norman Wolmark
Preoperative multimodality therapy improves disease-free survival in patients with carcinoma of the rectum: NSABP R-03.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(31):5124-30.
2009: Carmen J Allegra; Greg Yothers; Michael J O'Connell; Saima Sharif; Linda H Colangelo; Samia H Lopa; Nicholas J Petrelli; Richard M Goldberg; James N Atkins; Thomas E Seay; Louis Fehrenbacher; Seamus O'Reilly; Luis Chu; Catherine A Azar; Norman Wolmark
Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(20):3385-90.
2007: George P Kim; Linda H Colangelo; Soonmyung Paik; Michael J O'Connell; Ilan R Kirsch; Carmen J Allegra; Norman Wolmark
Predictive value of microsatellite instability-high remains controversial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(30):4857; author reply 4857-8.
2007: M Chen; Lambratu Rahman; Donna Voeller; EK Kastanos; S X Yang; L Feigenbaum; Carmen J Allegra; Frederic J Kaye; Patricia S Steeg; Maria Zajac-Kaye
Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas.
Oncogene 2007;26(33):4817-24.
2007: George P Kim; Linda H Colangelo; H Samuel Wieand; Soonmyung Paik; Ilan R Kirsch; Norman Wolmark; Carmen J Allegra
Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project Collaborative Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(7):767-72.
2005: Carmen J Allegra; Ray Hall; Greg Yothers
Prevalence of burnout in the u.s. Oncology community: results of a 2003 survey.
Journal of oncology practice / American Society of Clinical Oncology 2005;1(4):140-7.
2004: Lambratu Rahman; Donna Voeller; Monzur Rahman; Stan Lipkowitz; Carmen J Allegra; J Carl Barrett; Frederic J Kaye; Maria Zajac-Kaye
Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme.
Cancer cell 2004;5(4):341-51.
2003: Carmen J Allegra; Soonmyung Paik; Linda H Colangelo; Allyson L Parr; Ilan Kirsch; George Kim; Pamela Klein; Patrick G Johnston; Norman Wolmark; H Samuel Wieand
Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(2):241-50.
2002: Donna Voeller; Maria Zajac-Kaye; Robert J Fisher; Carmen J Allegra
The identification of thymidylate synthase peptide domains located in the interface region that bind thymidylate synthase mRNA.
Biochemical and biophysical research communications 2002;297(1):24-31.
2002: Carmen J Allegra; Allyson L Parr; Lester E Wold; Michelle R Mahoney; Daniel J Sargent; Patrick Johnston; Pamela Klein; Katie Behan; Michael J O'Connell; Ralph Levitt; John W Kugler; Maria Tria Tirona; Richard M Goldberg
Investigation of the prognostic and predictive value of thymidylate synthase, p53, and Ki-67 in patients with locally advanced colon cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(7):1735-43.
2001: Jean L Grem; LK Yee; Barbara Schuler; J Michael Hamilton; Alice P Chen; C Chabuk; Frank Grollman; M Grabenc; Carmen J Allegra; Chris H Takimoto
N-(phosphonacetyl)-L-aspartate and calcium leucovorin modulation of fluorouracil administered by constant rate and circadian pattern of infusion over 72 hours in metastatic gastrointestinal adenocarcinoma.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(11):1581-7.
2001: Rebecca R Thomas; William Dahut; Nancy Harold; Jean L Grem; Brian P Monahan; M Liang; RA Band; John R Cottrell; Victor Llorens; J A Smith; W Corse; Arbuck Susan; J Wright; Alice P Chen; JD Shapiro; J Michael Hamilton; Carmen J Allegra; Chris H Takimoto
A phase I and pharmacologic study of 9-aminocamptothecin administered as a 120-h infusion weekly to adult cancer patients.
Cancer chemotherapy and pharmacology 2001;48(3):215-22.
2001: Allyson L Parr; Timothy G Myers; Susan Holbeck; Y J Loh; Carmen J Allegra
Thymidylate synthase as a molecular target for drug discovery using the National Cancer Institute's Anticancer Drug Screen.
Anti-cancer drugs 2001;12(7):569-74.
2001: EK Kastanos; Maria Zajac-Kaye; P A Dennis; Carmen J Allegra
Downregulation of p21/WAF1 expression by thymidylate synthase.
Biochemical and biophysical research communications 2001;285(2):195-200.
2001: Donna Voeller; Allyson L Parr; Carmen J Allegra
Development of human anti-thymidine kinase antibodies.
Anti-cancer drugs 2001;12(6):555-9.
2001: Jean L Grem; K D Danenberg; Katie Behan; Allyson L Parr; L Young; P V Danenberg; Diana Nguyen; J Drake; Anne Monks; Carmen J Allegra
Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(4):999-1009.
2001: J Liu; L Grogan; Marion M Nau; Carmen J Allegra; Edward Chu; John J Wright
Physical interaction between p53 and primary response gene Egr-1.
International journal of oncology 2001;18(4):863-70.
2001: Jean L Grem; Mary Quinn; Abdel-Salam Attia Ismail; Chris H Takimoto; Richard M Lush; David J Liewehr; Seth M Steinberg; FRANK BALIS; Alice P Chen; Brian P Monahan; Nancy Harold; W Corse; Janet Pang; RF Murphy; Carmen J Allegra; J Michael Hamilton
Pharmacokinetics and pharmacodynamic effects of 5-fluorouracil given as a one-hour intravenous infusion.
Cancer chemotherapy and pharmacology 2001;47(2):117-25.
2001: Muhammad Wasif Saif; Richard F Little; J Michael Hamilton; Carmen J Allegra; Wyndham H Wilson
Reactivation of chronic hepatitis B infection following intensive chemotherapy and successful treatment with lamivudine: a case report and review of the literature.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(1):123-9.
2000: Muhammad Wasif Saif; J Michael Hamilton; Carmen J Allegra
Varicella zoster meningitis preceeded by thrombophlebitis in a patient with Hodgkin's disease.
Leukemia & lymphoma 2000;39(3-4):421-6.
2000: J Liu; Marion M Nau; J C Yeh; Carmen J Allegra; Edward Chu; John J Wright
Molecular heterogeneity and function of EWS-WT1 fusion transcripts in desmoplastic small round cell tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(9):3522-9.
2000: J Niklinski; GF Claassen; C Meyers; Mark A Gregory; Carmen J Allegra; Frederic J Kaye; Stephen R Hann; Maria Zajac-Kaye
Disruption of Myc-tubulin interaction by hyperphosphorylation of c-Myc during mitosis or by constitutive hyperphosphorylation of mutant c-Myc in Burkitt's lymphoma.
Molecular and cellular biology 2000;20(14):5276-84.
2000: A Itkes; Carmen J Allegra; Maria Zajac-Kaye
Multiprotein complexes present at the MIF motifs flanking the promoter of the human c-myc gene.
FEBS letters 2000;474(1):23-8.
2000: Lee Pai-Scherf; Jorge Carrasquillo; Chang H Paik; Otto A Gansow; Millie Whatley; D Pearson; KO Webber; Michael Hamilton; Carmen J Allegra; Martin W Brechbiel; Mark C Willingham; Ira Pastan
Imaging and phase I study of 111In- and 90Y-labeled anti-LewisY monoclonal antibody B3.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(5):1720-30.
2000: Xiukun Lin; Leslie A Parsels; Donna Voeller; Carmen J Allegra; Gladys F Maley; Frank Maley; Edward Chu
Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA.
Nucleic acids research 2000;28(6):1381-9.
2000: Erwin A Kruger; Paul H Duray; M G Tsokos; David J Venzon; Steven Libutti; Shannon C Dixon; MICHELLE RUDEK-RENAUT; James M Pluda; Carmen J Allegra; William D Figg
Endostatin inhibits microvessel formation in the ex vivo rat aortic ring angiogenesis assay.
Biochemical and biophysical research communications 2000;268(1):183-91.
2000: Chris H Takimoto; Geraldine Morrison; Nancy Harold; Mary Quinn; Brian P Monahan; RA Band; John R Cottrell; A Guemei; Victor Llorens; H Hehman; Abdel-Salam Attia Ismail; D Flemming; David Gosky; H Hirota; Sosamma J Berger; Nathan A Berger; Alice P Chen; JD Shapiro; Arbuck Susan; J Wright; J Michael Hamilton; Carmen J Allegra; Jean L Grem
Phase I and pharmacologic study of irinotecan administered as a 96-hour infusion weekly to adult cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(3):659-67.
2000: Maria Zajac-Kaye; N Ben-Baruch; EK Kastanos; Frederic J Kaye; Carmen J Allegra
Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells.
The Biochemical journal 2000;345 Pt 3():535-41.
2000: Donna Voeller; Jean L Grem; Y Pommier; K Paull; Carmen J Allegra
Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs.
Cancer chemotherapy and pharmacology 2000;45(5):409-16.
1999: JD Shapiro; Nancy Harold; Chris H Takimoto; J Michael Hamilton; David Vaughn; Alice Chen; Seth M Steinberg; David J Liewehr; Carmen J Allegra; Brian P Monahan; Alex E Lash; Frank Grollman; D Flemming; Katie Behan; Patrick G Johnston; Daniel Haller; Mary Quinn; Geraldine Morrison; Jean L Grem
A pilot study of interferon alpha-2a, fluorouracil, and leucovorin given with granulocyte-macrophage colony stimulating factor in advanced gastrointestinal adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2399-408.
1999: Jean L Grem; JM Sorensen; E Cullen; Chris H Takimoto; Seth M Steinberg; Alice P Chen; J Michael Hamilton; Arbuck Susan; N McAtee; D Lawrence; Barry Goldspiel; Patrick G Johnston; Carmen J Allegra
A Phase I study of raltitrexed, an antifolate thymidylate synthase inhibitor, in adult patients with advanced solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2381-91.
1999: Chris H Takimoto; LK Yee; David J Venzon; Barbara Schuler; Frank Grollman; C Chabuk; J Michael Hamilton; Alice P Chen; Carmen J Allegra; Jean L Grem
High inter- and intrapatient variation in 5-fluorouracil plasma concentrations during a prolonged drug infusion.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(6):1347-52.
1999: Carmen J Allegra
Antifolates: the next millennium.
Seminars in oncology 1999;26(2 Suppl 6):1-2.
1999: Samir N Khleif; Scott I Abrams; J Michael Hamilton; Elke Bergmann-Leitner; A Chen; A Bastian; S Bernstein; Y Chung; Carmen J Allegra; Jeffrey Schlom
A phase I vaccine trial with peptides reflecting ras oncogene mutations of solid tumors.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1999;22(2):155-65.
1999: Edward Chu; Sitki Copur; Jingfang Ju; Tian-min Chen; Samir N Khleif; Donna Voeller; N Mizunuma; M Patel; Gladys F Maley; Frank Maley; Carmen J Allegra
Thymidylate synthase protein and p53 mRNA form an in vivo ribonucleoprotein complex.
Molecular and cellular biology 1999;19(2):1582-94.
1998: Norman Wolmark; John Bryant; Roy Smith; Jean L Grem; Carmen J Allegra; DM Hyams; J Atkins; NV Dimitrov; R Oishi; Diane Prager; Louis Fehrenbacher; Edward Romond; Linda H Colangelo; Bernard Fisher
Adjuvant 5-fluorouracil and leucovorin with or without interferon alfa-2a in colon carcinoma: National Surgical Adjuvant Breast and Bowel Project protocol C-05.
Journal of the National Cancer Institute 1998;90(23):1810-6.
1998: Allyson L Parr; J C Drake; R E Gress; G Schwartz; Seth M Steinberg; Carmen J Allegra
5-fluorouracil-mediated thymidylate synthase induction in malignant and nonmalignant human cells.
Biochemical pharmacology 1998;56(2):231-5.
1998: Katie Behan; Patrick G Johnston; Carmen J Allegra
Epitope mapping of a series of human thymidylate synthase monoclonal antibodies.
Cancer research 1998;58(12):2606-11.
1998: Jean L Grem; Seth M Steinberg; Alice P Chen; N McAtee; E Cullen; J Michael Hamilton; Carmen J Allegra
The utility of monitoring carcinoembyronic antigen during systemic therapy for advanced colorectal cancer.
Oncology reports 1998;5(3):559-67.
1998: A Ismail; Cees J van Groeningen; Anthea Hardcastle; Q Ren; G Wynne Aherne; FJ Geoffroy; Carmen J Allegra; Jean L Grem
Modulation of fluorouracil cytotoxicity by interferon-alpha and -gamma.
Molecular pharmacology 1998;53(2):252-61.
1997: Jean L Grem; N McAtee; RF Murphy; FRANK BALIS; E Cullen; Alice P Chen; J Michael Hamilton; Seth M Steinberg; Mary Quinn; JM Sorensen; Arbuck Susan; D Lawrence; Janet Pang; Carmen J Allegra
A pilot study of gamma-1b-interferon in combination with fluorouracil, leucovorin, and alpha-2a-interferon.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(7):1125-34.
1997: Bernhard C Pestalozzi; HF Peterson; Richard D Gelber; Aron Goldhirsch; Barry A Gusterson; Helen Trihia; Jurij Lindtner; Hernán Cortés-Funes; E Simmoncini; Michael J Byrne; Rastko Golouh; Carl-Magnus Rudenstam; Monica Castiglione-Gertsch; Carmen J Allegra; Patrick G Johnston
Prognostic importance of thymidylate synthase expression in early breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(5):1923-31.
1997: Chris H Takimoto; William Dahut; M T Marino; H Nakashima; M D Liang; Nancy Harold; Richard W Lieberman; Arbuck Susan; RA Band; Alice P Chen; J Michael Hamilton; L R Cantilena; Carmen J Allegra; Jean L Grem
Pharmacodynamics and pharmacokinetics of a 72-hour infusion of 9-aminocamptothecin in adult cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(4):1492-501.
1997: J Liu; Marion M Nau; J Zucman-Rossi; John I Powell; Carmen J Allegra; John J Wright
LINE-I element insertion at the t(11;22) translocation breakpoint of a desmoplastic small round cell tumor.
Genes, chromosomes & cancer 1997;18(3):232-9.
1997: Patrick G Johnston; R Mick; Wendy Recant; Katie Behan; M E Dolan; M J Ratain; Enrique Beckmann; Ralph R Weichselbaum; Carmen J Allegra; E E Vokes
Thymidylate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer.
Journal of the National Cancer Institute 1997;89(4):308-13.
1997: John J Wright; K J Hoffmeister; J D Cotelingam; Carmen J Allegra
Neutrophilia and organomegaly in two patients with cancer.
Hospital practice (1995) 1997;32(1):135-6, 139-42.
1997: Jean L Grem; LK Yee; David J Venzon; Chris H Takimoto; Carmen J Allegra
Inter- and intraindividual variation in dihydropyrimidine dehydrogenase activity in peripheral blood mononuclear cells.
Cancer chemotherapy and pharmacology 1997;40(2):117-25.
1997: Q Ren; Cees J van Groeningen; Anthea Hardcastle; G Wynne Aherne; FJ Geoffroy; Carmen J Allegra; Patrick G Johnston; Jean L Grem
Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
Oncology research 1997;9(2):77-88.
1996: Chris H Takimoto; William Dahut; Nancy Harold; H Nakashima; Ronald Lieberman; M D Liang; Arbuck Susan; Alice P Chen; J Michael Hamilton; L R Cantilena; Carmen J Allegra; Jean L Grem
Clinical pharmacology of 9-aminocamptothecin.
Annals of the New York Academy of Sciences 1996;803():324-6.
1996: Patrick G Johnston; F Geoffrey; J Drake; D Voeller; Jean L Grem; Carmen J Allegra
The cellular interaction of 5-fluorouracil and cisplatin in a human colon carcinoma cell line.
European journal of cancer (Oxford, England : 1990) 1996;32A(12):2148-54.
1996: Edward Chu; T Cogliati; Sitki Copur; A Borre; D M Voeller; Carmen J Allegra; S Segal
Identification of in vivo target RNA sequences bound by thymidylate synthase.
Nucleic acids research 1996;24(16):3222-8.
1996: Jean L Grem; P M Politi; S L Berg; N M Benchekroun; M Patel; FRANK BALIS; B K Sinha; William Dahut; Carmen J Allegra
Cytotoxicity and DNA damage associated with pyrazoloacridine in MCF-7 breast cancer cells.
Biochemical pharmacology 1996;51(12):1649-59.
1996: BK Temeck; J E Liebmann; C Theodossiou; Seth M Steinberg; John A Cook; D C Metz; T H Shawker; Carmen J Allegra; Angelo Russo; Harvey I Pass
Phase II trial of 5-fluorouracil, leucovorin, interferon-alpha-2a, and cisplatin as neoadjuvant chemotherapy for locally advanced esophageal carcinoma.
Cancer 1996;77(12):2432-9.
1996: B Yu; Jorge Carrasquillo; Diane E Milenic; Y Chung; P Perentesis; I Feuerestein; D Eggensperger; C F Qi; Chang H Paik; J Reynolds; Jean L Grem; G Curt; K Siler; Jeffrey Schlom; Carmen J Allegra
Phase I trial of iodine 131-labeled COL-1 in patients with gastrointestinal malignancies: influence of serum carcinoembryonic antigen and tumor bulk on pharmacokinetics.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(6):1798-809.
1996: J C Drake; Carmen J Allegra; R G Moran; Patrick G Johnston
Resistance to tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines.
Biochemical pharmacology 1996;51(10):1349-55.
1996: William Dahut; Nancy Harold; Chris H Takimoto; Carmen J Allegra; A Chen; J Michael Hamilton; Arbuck Susan; M Sorensen; Frank Grollman; H Nakashima; Ronald Lieberman; M Liang; W Corse; Jean L Grem
Phase I and pharmacologic study of 9-aminocamptothecin given by 72-hour infusion in adult cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(4):1236-44.
1996: Chris H Takimoto; Z H Lu; R Zhang; M D Liang; L V Larson; L R Cantilena; Jean L Grem; Carmen J Allegra; R B Diasio; Edward Chu
Severe neurotoxicity following 5-fluorouracil-based chemotherapy in a patient with dihydropyrimidine dehydrogenase deficiency.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(3):477-81.
1996: Edward Chu; Carmen J Allegra
The role of thymidylate synthase as an RNA binding protein.
BioEssays : news and reviews in molecular, cellular and developmental biology 1996;18(3):191-8.
1996: Edward Chu; Carmen J Allegra
Mechanisms of clinical resistance to 5-fluorouracil chemotherapy.
Cancer treatment and research 1996;87():175-95.
1996: Edward Chu; Carmen J Allegra
The role of thymidylate synthase in cellular regulation.
Advances in enzyme regulation 1996;36():143-63.
1996: Edward Chu; Jean L Grem; Patrick G Johnston; Carmen J Allegra
New concepts for the development and use of antifolates.
Stem cells (Dayton, Ohio) 1996;14(1):41-6.
1996: Patrick G Johnston; Chris H Takimoto; Jean L Grem; B A Chabner; Carmen J Allegra; Edward Chu
Antimetabolites.
Cancer chemotherapy and biological response modifiers 1996;16():1-27.
1995: Patrick G Johnston; Katie Behan; Carmen J Allegra; J C Drake
Fluorouracil: active in ZD1694 (tomudex)-resistant cell lines with markedly elevated thymidylate synthase levels.
Journal of the National Cancer Institute 1995;87(20):1558-9.
1995: Patrick G Johnston; Carmen J Allegra
Colorectal cancer biology: clinical implications.
Seminars in oncology 1995;22(5):418-32.
1995: Carmen J Allegra
Tamoxifen, uridine transport, and dome formation in human breast cancer cells.
The cancer journal from Scientific American 1995;1(3):182-3.
1995: Jean L Grem; F Geoffroy; P M Politi; D P Cuddy; Douglas Ross; D Nguyen; Seth M Steinberg; Carmen J Allegra
Determinants of sensitivity to 1-beta-D-arabinofuranosylcytosine in HCT 116 and NCI-H630 human colon carcinoma cells.
Molecular pharmacology 1995;48(2):305-15.
1995: B C Pestalozzi; C J McGinn; Timothy J Kinsella; J C Drake; M C Glennon; Carmen J Allegra; Patrick G Johnston
Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells.
British journal of cancer 1995;71(6):1151-7.
1995: J C Drake; D M Voeller; Carmen J Allegra; Patrick G Johnston
The effect of dose and interval between 5-fluorouracil and leucovorin on the formation of thymidylate synthase ternary complex in human cancer cells.
British journal of cancer 1995;71(6):1145-50.
1995: Sitki Copur; K Aiba; J C Drake; Carmen J Allegra; Edward Chu
Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil.
Biochemical pharmacology 1995;49(10):1419-26.
1995: P G Johnston; Heinz-Josef Lenz; Cynthia G Leichman; Kathleen D Danenberg; Carmen J Allegra; Peter V Danenberg; Lawrence Leichman
Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.
Cancer research 1995;55(7):1407-12.
1995: D M Voeller; Liming Changchien; Gladys F Maley; Frank Maley; T Takechi; R E Turner; William R Montfort; Carmen J Allegra; Edward Chu
Characterization of a specific interaction between Escherichia coli thymidylate synthase and Escherichia coli thymidylate synthase mRNA.
Nucleic acids research 1995;23(5):869-75.
1995: Sitki Copur; William Dahut; Edward Chu; Carmen J Allegra
Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.
Anti-cancer drugs 1995;6(1):154-7.
1995: Carmen J Allegra
New therapeutic strategies for patients with gastrointestinal malignancies using biochemical modulation of fluorouracil.
JAMA : the journal of the American Medical Association 1995;273(3):236-9.
1995: M K Hong; W B Laskin; B E Herman; M H Johnston; J J Vargo; Seth M Steinberg; Carmen J Allegra; P G Johnston
Expansion of the Ki-67 proliferative compartment correlates with degree of dysplasia in Barrett's esophagus.
Cancer 1995;75(2):423-9.
1995: Edward Chu; T Takechi; K L Jones; D M Voeller; Sitki Copur; Gladys F Maley; Frank Maley; S Segal; Carmen J Allegra
Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro.
Molecular and cellular biology 1995;15(1):179-85.
1995: P M Politi; F Xie; William Dahut; Harry Ford; James A Kelley; A Bastian; A Setser; Carmen J Allegra; Alice P Chen; J Michael Hamilton
Phase I clinical trial of continuous infusion cyclopentenyl cytosine.
Cancer chemotherapy and pharmacology 1995;36(6):513-23.
1994: Patrick G Johnston; Edwin R Fisher; H E Rockette; Bernard Fisher; N Wolmark; J C Drake; B A Chabner; Carmen J Allegra
The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1994;12(12):2640-7.
1994: Jean L Grem; D M Voeller; F Geoffroy; E Horak; Patrick G Johnston; Carmen J Allegra
Determinants of trimetrexate lethality in human colon cancer cells.
British journal of cancer 1994;70(6):1075-84.
1994: Jean L Grem; P Daychild; J Drake; F Geoffroy; Jane Trepel; F Pirnia; Carmen J Allegra
Cytotoxicity and metabolism of 4-methoxy-8-(beta-D-ribofuranosylamino)pyrimido[5,4-d]pyrimidine in HCT 116 colon cancer cells.
Biochemical pharmacology 1994;48(11):2117-26.
1994: Edward Chu; D M Voeller; Paul F Morrison; K L Jones; T Takechi; Gladys F Maley; Frank Maley; Carmen J Allegra
The effect of reducing reagents on binding of thymidylate synthase protein to thymidylate synthase messenger RNA.
The Journal of biological chemistry 1994;269(32):20289-93.
1994: Chris H Takimoto; Raymond W Klecker; William Dahut; L K Yee; John M Strong; Carmen J Allegra; Jean L Grem
Analysis of the active lactone form of 9-aminocamptothecin in plasma using solid-phase extraction and high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications 1994;655(1):97-104.
1994: D Voeller; J Kovacs; V Andrawis; Edward Chu; H Masur; Carmen J Allegra
Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone).
The Journal of infectious diseases 1994;169(2):456-9.
1994: Edward Chu; D M Voeller; K L Jones; T Takechi; Gladys F Maley; Frank Maley; S Segal; Carmen J Allegra
Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells.
Molecular and cellular biology 1994;14(1):207-13.
1994: F J Geoffroy; Carmen J Allegra; B Sinha; Jean L Grem
Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells.
Oncology research 1994;6(12):581-91.
1994: Edward Chu; Patrick G Johnston; Jean L Grem; Chris H Takimoto; C Van Groeningen; B A Chabner; Carmen J Allegra
Antimetabolites.
Cancer chemotherapy and biological response modifiers 1994;15():1-31.
1994: D M Voeller; Carmen J Allegra
Intracellular metabolism of 5-methyltetrahydrofolate and 5-formyltetrahydrofolate in a human breast-cancer cell line.
Cancer chemotherapy and pharmacology 1994;34(6):491-6.
1994: G A Sotos; Liam Grogan; Carmen J Allegra
Preclinical and clinical aspects of biomodulation of 5-fluorouracil.
Cancer treatment reviews 1994;20(1):11-49.
1993: Chris H Takimoto; D B Voeller; John M Strong; L Anderson; Edward Chu; Carmen J Allegra
Effects of 5-fluorouracil substitution on the RNA conformation and in vitro translation of thymidylate synthase messenger RNA.
The Journal of biological chemistry 1993;268(28):21438-42.
1993: Riad Agbaria; Harry Ford; James A Kelley; F Xie; P Politi; Jean L Grem; D A Cooney; Victor E Marquez; Carmen J Allegra; David G Johns
Measurement of cyclopentenyl cytosine 5'-triphosphate in vitro and in vivo by multidimensional high-performance liquid chromatography.
Analytical biochemistry 1993;213(1):90-6.
1993: J C Drake; Carmen J Allegra; Patrick G Johnston
Immunological quantitation of thymidylate synthase-FdUMP-5,10-methylenetetrahydrofolate ternary complex with the monoclonal antibody TS 106.
Anti-cancer drugs 1993;4(4):431-5.
1993: Liam Grogan; G A Sotos; Carmen J Allegra
Leucovorin modulation of fluorouracil.
Oncology (Williston Park, N.Y.) 1993;7(8):63-72; discussion 75-6.
1993: Jean L Grem; N McAtee; FRANK BALIS; R Murphy; David Venzon; B Kramer; Barry Goldspiel; M Begley; Carmen J Allegra
A phase II study of continuous infusion 5-fluorouracil and leucovorin with weekly cisplatin in metastatic colorectal carcinoma.
Cancer 1993;72(3):663-8.
1993: Patrick G Johnston; J C Drake; Seth M Steinberg; Carmen J Allegra
Quantitation of thymidylate synthase in human tumors using an ultrasensitive enzyme-linked immunoassay.
Biochemical pharmacology 1993;45(12):2483-6.
1993: Joseph A Kovacs; F Powell; D Voeller; Carmen J Allegra
Inhibition of Pneumocystis carinii dihydropteroate synthetase by para-acetamidobenzoic acid: possible mechanism of action of isoprinosine in human immunodeficiency virus infection.
Antimicrobial agents and chemotherapy 1993;37(6):1227-31.
1993: Edward Chu; Chris H Takimoto; D Voeller; Jean L Grem; Carmen J Allegra
Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro.
Biochemistry 1993;32(18):4756-60.
1993: H Richard Alexander; Jean L Grem; Harvey I Pass; M Hamilton; N McAtee; Douglas L Fraker; Carmen J Allegra
Neoadjuvant chemotherapy for locally advanced gastric adenocarcinoma.
Oncology (Williston Park, N.Y.) 1993;7(5):37-42; discussion 42-4, 49-50, 53.
1993: S Gupta-Burt; H Shamkhani; Eddie Reed; Robert E Tarone; Carmen J Allegra; L H Pai; Miriam C Poirier
Relationship between patient response in ovarian and breast cancer and platinum drug-DNA adduct formation.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1993;2(3):229-34.
1993: Edward Chu; David M Koeller; Patrick G Johnston; S Zinn; Carmen J Allegra
Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma.
Molecular pharmacology 1993;43(4):527-33.
1993: Edward Chu; D Voeller; David M Koeller; J C Drake; Chris H Takimoto; Gladys F Maley; Frank Maley; Carmen J Allegra
Identification of an RNA binding site for human thymidylate synthase.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):517-21.
1993: Edward Chu; Patrick G Johnston; Chris H Takimoto; P M Politi; Jean L Grem; B A Chabner; Carmen J Allegra
Antimetabolites.
Cancer chemotherapy and biological response modifiers 1993;14():1-25.
1993: Carmen J Allegra; D Voeller
Clinical use of leucovorin: intracellular metabolism.
Advances in experimental medicine and biology 1993;339():43-9; discussion 55-6.
1993: Edward Chu; Carmen J Allegra
Regulation of thymidylate synthase in human colon cancer cells treated with 5-fluorouracil and interferon-gamma.
Advances in experimental medicine and biology 1993;339():143-51; discussion 165-7.
1993: Jean L Grem; N McAtee; J C Drake; S Steinberg; Carmen J Allegra
Dose-dependent inhibition of aspartate carbamoyltransferase in peripheral blood mononuclear cells in patients receiving N-(phosphonacetyl)-L-aspartate.
Advances in experimental medicine and biology 1993;339():119-23.
1992: Patrick G Johnston; cristina Rondinone; D Voeller; Carmen J Allegra
Identification of a protein factor secreted by 3T3-L1 preadipocytes inhibitory for the human MCF-7 breast cancer cell line.
Cancer research 1992;52(24):6860-5.
1992: L K Yee; Carmen J Allegra; Seth M Steinberg; Jean L Grem
Decreased catabolism of fluorouracil in peripheral blood mononuclear cells during combination therapy with fluorouracil, leucovorin, and interferon alpha-2a.
Journal of the National Cancer Institute 1992;84(23):1820-5.
1992: L H Pai; S M Swain; D J Venzon; Eddie Reed; Miriam C Poirier; S Gupta-Burt; A M Denicoff; Carmen J Allegra
Therapy of patients with metastatic breast cancer with 5-fluorouracil, leucovorin and carboplatin.
Anti-cancer drugs 1992;3(5):463-9.
1992: Patrick G Johnston; J C Drake; Jane Trepel; Carmen J Allegra
Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines.
Cancer research 1992;52(16):4306-12.
1992: L K Yee; Carmen J Allegra; Jane Trepel; Jean L Grem
Metabolism and RNA incorporation of cyclopentenyl cytosine in human colorectal cancer cells.
Biochemical pharmacology 1992;43(7):1587-99.
1992: Jean L Grem; Edward Chu; D Boarman; FRANK BALIS; RF Murphy; N McAtee; Carmen J Allegra
Biochemical modulation of fluorouracil with leucovorin and interferon: preclinical and clinical investigations.
Seminars in oncology 1992;19(2 Suppl 3):36-44.
1992: Edward Chu; Jean L Grem; Patrick G Johnston; P M Politi; B A Chabner; Carmen J Allegra
Antimetabolites.
Cancer chemotherapy and biological response modifiers 1992;13():1-30.
1992: D M Boarman; Carmen J Allegra
Intracellular metabolism of 5-formyl tetrahydrofolate in human breast and colon cell lines.
Cancer research 1992;52(1):36-44.
1991: Patrick G Johnston; C M Liang; S Henry; B A Chabner; Carmen J Allegra
Production and characterization of monoclonal antibodies that localize human thymidylate synthase in the cytoplasm of human cells and tissue.
Cancer research 1991;51(24):6668-76.
1991: Edward Chu; David M Koeller; J L Casey; J C Drake; B A Chabner; P C Elwood; S Zinn; Carmen J Allegra
Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(20):8977-81.
1991: Jean L Grem; Carmen J Allegra
Sequence-dependent interaction of 5-fluorouracil and arabinosyl-5-azacytosine or 1-beta-D-arabinofuranosylcytosine.
Biochemical pharmacology 1991;42(2):409-18.
1991: Edward Chu; J C Drake; David M Koeller; S Zinn; CA Jamis-Dow; G C Yeh; Carmen J Allegra
Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines.
Molecular pharmacology 1991;39(2):136-43.
1990: D M Boarman; J Baram; Carmen J Allegra
Mechanism of leucovorin reversal of methotrexate cytotoxicity in human MCF-7 breast cancer cells.
Biochemical pharmacology 1990;40(12):2651-60.
1990: Jean L Grem; Carmen J Allegra
Enhancement of the toxicity and DNA incorporation of arabinosyl-5-azacytosine and 1-beta-D-arabinofuranosylcytosine by cyclopentenyl cytosine.
Cancer research 1990;50(22):7279-84.
1990: Edward Chu; S Zinn; D Boarman; Carmen J Allegra
Interaction of gamma interferon and 5-fluorouracil in the H630 human colon carcinoma cell line.
Cancer research 1990;50(18):5834-40.
1990: Edward Chu; G M Lai; S Zinn; Carmen J Allegra
Resistance of a human ovarian cancer line to 5-fluorouracil associated with decreased levels of 5-fluorouracil in DNA.
Molecular pharmacology 1990;38(3):410-7.
1990: Carmen J Allegra; D Boarman
Interaction of methotrexate polyglutamates and dihydrofolate during leucovorin rescue in a human breast cancer cell line (MCF-7).
Cancer research 1990;50(12):3574-8.
1990: Edward Chu; J C Drake; D Boarman; J Baram; Carmen J Allegra
Mechanism of thymidylate synthase inhibition by methotrexate in human neoplastic cell lines and normal human myeloid progenitor cells.
The Journal of biological chemistry 1990;265(15):8470-8.
1990: Carmen J Allegra; J Jenkins; Raymond B Weiss; FRANK BALIS; J C Drake; J Brooks; R Thomas; G A Curt
A phase I and pharmacokinetic study of trimetrexate using a 24-hour continuous-injection schedule.
Investigational new drugs 1990;8(2):159-66.
1990: J C Drake; J Baram; Carmen J Allegra
Isolation and characterization of a novel dihydrofolate formylating enzyme from human MCF-7 breast cancer cells.
Biochemical pharmacology 1990;39(3):615-8.
1990: Carmen J Allegra; D Boarman; Joseph A Kovacs; P Morrison; J Beaver; B A Chabner; Henry Masur
Interaction of sulfonamide and sulfone compounds with Toxoplasma gondii dihydropteroate synthase.
The Journal of clinical investigation 1990;85(2):371-9.
1990: Fred R Sattler; Carmen J Allegra; T D Verdegem; B Akil; C U Tuazon; C Hughlett; D Ogata-Arakaki; J Feinberg; James H Shelhamer; H Clifford Lane
Trimetrexate-leucovorin dosage evaluation study for treatment of Pneumocystis carinii pneumonia.
The Journal of infectious diseases 1990;161(1):91-6.
1989: Henry Masur; H Clifford Lane; Joseph A Kovacs; Carmen J Allegra; Jennifer C Edman
NIH conference. Pneumocystis pneumonia: from bench to clinic.
Annals of internal medicine 1989;111(10):813-26.
1989: Jean L Grem; Carmen J Allegra
Toxicity of levamisole and 5-fluorouracil in human colon carcinoma cells.
Journal of the National Cancer Institute 1989;81(18):1413-7.
1989: Joseph A Kovacs; Carmen J Allegra; J Beaver; D Boarman; M Lewis; J E Parrillo; B Chabner; Henry Masur
Characterization of de novo folate synthesis in Pneumocystis carinii and Toxoplasma gondii: potential for screening therapeutic agents.
The Journal of infectious diseases 1989;160(2):312-20.
1989: S M Swain; Marc Lippman; E F Egan; J C Drake; Seth M Steinberg; Carmen J Allegra
Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(7):890-9.
1989: Paul F Morrison; Carmen J Allegra
Folate cycle kinetics in human breast cancer cells.
The Journal of biological chemistry 1989;264(18):10552-66.
1988: J G Park; J M Collins; Adi F Gazdar; Carmen J Allegra; S M Steinberg; R F Greene; B S Kramer
Enhancement of fluorinated pyrimidine-induced cytotoxicity by leucovorin in human colorectal carcinoma cell lines.
Journal of the National Cancer Institute 1988;80(19):1560-4.
1988: Joseph A Kovacs; Carmen J Allegra; S Kennedy; J C Swan; J Drake; J E Parrillo; B Chabner; Henry Masur
Efficacy of trimetrexate, a potent lipid-soluble antifolate, in the treatment of rodent Pneumocystis carinii pneumonia.
The American journal of tropical medicine and hygiene 1988;39(5):491-6.
1988: P W Sholar; J Baram; R Seither; Carmen J Allegra
Inhibition of folate-dependent enzymes by 7-OH-methotrexate.
Biochemical pharmacology 1988;37(18):3531-4.
1988: J Baram; B A Chabner; J C Drake; A L Fitzhugh; P W Sholar; Carmen J Allegra
Identification and biochemical properties of 10-formyldihydrofolate, a novel folate found in methotrexate-treated cells.
The Journal of biological chemistry 1988;263(15):7105-11.
1988: Joseph A Kovacs; Carmen J Allegra; J C Swan; J C Drake; J E Parrillo; B A Chabner; Henry Masur
Potent antipneumocystis and antitoxoplasma activities of piritrexim, a lipid-soluble antifolate.
Antimicrobial agents and chemotherapy 1988;32(4):430-3.
1988: Carmen J Allegra; B A Chabner; C U Tuazon; D Ogata-Arakaki; B Baird; J C Drake; Henry Masur
Treatment of Pneumocystis carinii pneumonia with trimetrexate in acquired immunodeficiency syndrome (AIDS).
Seminars in oncology 1988;15(2 Suppl 2):46-9.
1988: P Rogers; Carmen J Allegra; R F Murphy; J C Drake; Henry Masur; David G Poplack; B A Chabner; J E Parrillo; H Clifford Lane; FRANK BALIS
Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome.
Antimicrobial agents and chemotherapy 1988;32(3):324-6.
1988: Carmen J Allegra; G F Egan; J C Drake; Seth M Steinberg; S M Swain
The treatment of metastatic breast cancer with 5-fluorouracil and leucovorin.
Advances in experimental medicine and biology 1988;244():107-12.
1987: Carmen J Allegra; B A Chabner; C U Tuazon; D Ogata-Arakaki; B Baird; J C Drake; J T Simmons; E E Lack; James H Shelhamer; FRANK BALIS
Trimetrexate for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome.
The New England journal of medicine 1987;317(16):978-85.
1987: Carmen J Allegra; K Hoang; G C Yeh; J C Drake; J Baram
Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate.
The Journal of biological chemistry 1987;262(28):13520-6.
1987: J C Drake; Carmen J Allegra; J Baram; B T Kaufman; B A Chabner
Effects on dihydrofolate reductase of methotrexate metabolites and intracellular folates formed following methotrexate exposure of human breast cancer cells.
Biochemical pharmacology 1987;36(14):2416-8.
1987: Joseph A Kovacs; Carmen J Allegra; B A Chabner; J C Swan; J Drake; M Lunde; J E Parrillo; Henry Masur
Potent effect of trimetrexate, a lipid-soluble antifolate, on Toxoplasma gondii.
The Journal of infectious diseases 1987;155(5):1027-32.
1987: Carmen J Allegra; Joseph A Kovacs; J C Drake; J C Swan; B A Chabner; Henry Masur
Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent.
The Journal of experimental medicine 1987;165(3):926-31.
1987: Carmen J Allegra; Joseph A Kovacs; J C Drake; J C Swan; B A Chabner; Henry Masur
Potent in vitro and in vivo antitoxoplasma activity of the lipid-soluble antifolate trimetrexate.
The Journal of clinical investigation 1987;79(2):478-82.
1987: Carmen J Allegra; B A Chabner; P W Sholar; C Bagley; J C Drake; Marc Lippman
Preliminary results of a phase II trial for the treatment of metastatic breast cancer with 5-fluorouracil and leucovorin.
NCI monographs : a publication of the National Cancer Institute 1987;(5):199-202.
1987: A L Fitzhugh; B A Chabner; P W Sholar; J Baram; Carmen J Allegra
Antifolate metabolism and sites of action: implications for the design of new antifolates.
NCI monographs : a publication of the National Cancer Institute 1987;(5):153-7.
1987: Carmen J Allegra; J Baram; B A Chabner; G C Yeh; K Aiba; G A Curt
Antimetabolites.
Cancer chemotherapy and biological response modifiers 1987;9():1-22.
1985: B A Chabner; Carmen J Allegra; G A Curt; N J Clendeninn; J Baram; S Koizumi; J C Drake; J Jolivet
Polyglutamation of methotrexate. Is methotrexate a prodrug?
The Journal of clinical investigation 1985;76(3):907-12.
1985: Carmen J Allegra; B A Chabner; J C Drake; R Lutz; D Rodbard; J Jolivet
Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates.
The Journal of biological chemistry 1985;260(17):9720-6.
1985: Carmen J Allegra; J C Drake; J Jolivet; B A Chabner
Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(15):4881-5.
1985: Carmen J Allegra; J C Drake; B A Bell; G A Curt; B A Chabner
Measuring levels of methotrexate.
The New England journal of medicine 1985;313(3):184.
1985: J C Drake; Carmen J Allegra; G A Curt; B A Chabner
Competitive protein-binding assay for trimetrexate.
Cancer treatment reports 1985;69(6):641-4.