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Janet Connolly

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Ted H Hansen; Janet M Connolly; Keith G Gould; daved fremont
Basic and translational applications of engineered MHC class I proteins.
Baomei Wang; Tina M Primeau; Nancy Myers; Henry W Rohrs; Michael L Gross; Lonnie Lybarger; Ted H Hansen; Janet M Connolly
A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire.
Steven M Truscott; Xiaoli Wang; Lonnie Lybarger; William E Biddison; Cortez McBerry; John M Martinko; Janet M Connolly; Gerald P Linette; daved fremont; Ted H Hansen; Beatriz M Carreno
Human major histocompatibility complex (MHC) class I molecules with disulfide traps secure disease-related antigenic peptides and exclude competitor peptides.

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All Publications

2010: Ted H Hansen; Janet M Connolly; Keith G Gould; daved fremont
Basic and translational applications of engineered MHC class I proteins.
Trends in immunology 2010;31(10):363-9.
2009: Baomei Wang; Tina M Primeau; Nancy Myers; Henry W Rohrs; Michael L Gross; Lonnie Lybarger; Ted H Hansen; Janet M Connolly
A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire.
Science (New York, N.Y.) 2009;326(5954):871-4.
2008: Steven M Truscott; Xiaoli Wang; Lonnie Lybarger; William E Biddison; Cortez McBerry; John M Martinko; Janet M Connolly; Gerald P Linette; daved fremont; Ted H Hansen; Beatriz M Carreno
Human major histocompatibility complex (MHC) class I molecules with disulfide traps secure disease-related antigenic peptides and exclude competitor peptides.
The Journal of biological chemistry 2008;283(12):7480-90.
2007: Vesselin Mitaksov; Steven M Truscott; Lonnie Lybarger; Janet M Connolly; Ted H Hansen; daved fremont
Structural engineering of pMHC reagents for T cell vaccines and diagnostics.
Chemistry & biology 2007;14(8):909-22.
2007: Steven M Truscott; Lonnie Lybarger; John M Martinko; Vesselin Mitaksov; David M Kranz; Janet M Connolly; daved fremont; Ted H Hansen
Disulfide bond engineering to trap peptides in the MHC class I binding groove.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6280-9.
2005: Tina Primeau; Nancy Myers; Yik Y L Yu; Lonnie Lybarger; Xiaoli Wang; Steven M Truscott; Ted H Hansen; Janet M Connolly
Applications of major histocompatibility complex class I molecules expressed as single chains.
Immunologic research 2005;32(1-3):109-21.
2003: Lonnie Lybarger; Yik Y L Yu; Michael Miley; daved fremont; Nancy Myers; Tina Primeau; Steven M Truscott; Janet M Connolly; Ted H Hansen
Enhanced immune presentation of a single-chain major histocompatibility complex class I molecule engineered to optimize linkage of a C-terminally extended peptide.
The Journal of biological chemistry 2003;278(29):27105-11.
2003: Tara M C Hornell; Nancy Myers; Ted H Hansen; Janet M Connolly
Homology between an alloantigen and a self MHC allele calibrates the avidity of the alloreactive T cell repertoire independent of TCR affinity.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(9):4506-14.
2002: Yik Y L Yu; Nikolai Netuschil; Lonnie Lybarger; Janet M Connolly; Ted H Hansen
Cutting edge: single-chain trimers of MHC class I molecules form stable structures that potently stimulate antigen-specific T cells and B cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(7):3145-9.
2001: Tara M C Hornell; S M Martin; Nancy Myers; Janet M Connolly
Peptide length variants p2Ca and QL9 present distinct conformations to L(d)-specific T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4207-14.
2000: Nancy Myers; Michael R Harris; Janet M Connolly; Lonnie Lybarger; Yik Y L Yu; Ted H Hansen
Kb, Kd, and Ld molecules share common tapasin dependencies as determined using a novel epitope tag.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5656-63.
1999: Tara M C Hornell; Joyce C Solheim; Nancy Myers; William E Gillanders; GK Balendiran; Ted H Hansen; Janet M Connolly
Alloreactive and syngeneic CTL are comparably dependent on interaction with MHC class I alpha-helical residues.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(6):3217-25.
1997: J R Cook; E M Wormstall; Tara M C Hornell; J Russell; Janet M Connolly; Ted H Hansen
Quantitation of the cell surface level of Ld resulting in positive versus negative selection of the 2C transgenic T cell receptor in vivo.
Immunity 1997;7(2):233-41.
1997: William E Gillanders; H L Hanson; Ronald J Rubocki; Ted H Hansen; Janet M Connolly
Class I-restricted cytotoxic T cell recognition of split peptide ligands.
International immunology 1997;9(1):81-9.
1995: B M Carreno; Joyce C Solheim; M Harris; I Stroynowski; Janet M Connolly; Ted H Hansen
TAP associates with a unique class I conformation, whereas calnexin associates with multiple class I forms in mouse and man.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4726-33.
1995: J R Cook; Joyce C Solheim; Janet M Connolly; Ted H Hansen
Induction of peptide-specific CD8+ CTL clones in beta 2-microglobulin-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(1):47-57.
1994: Janet M Connolly
The peptide p2Ca is immunodominant in allorecognition of Ld by beta chain variable region V beta 8+ but not V beta 8- strains.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11482-6.
1994: M Alexander-Miller; R A Robinson; J D Smith; William E Gillanders; L G Harrison; Ted H Hansen; Janet M Connolly; David R Lee
Definition of TCR recognition sites on Ld-tum- complexes.
International immunology 1994;6(11):1699-707.
1993: J A Goss; Martha Alexander-Miller; J Gorka; M Wayne Flye; Janet M Connolly; Ted H Hansen
Specific prolongation of allograft survival by a T-cell-receptor-derived peptide.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(21):9872-6.
1993: Martha Alexander-Miller; K Burke; U H Koszinowski; Ted H Hansen; Janet M Connolly
Alloreactive cytotoxic T lymphocytes generated in the presence of viral-derived peptides show exquisite peptide and MHC specificity.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(1):1-10.
1993: Joyce C Solheim; Martha Alexander-Miller; J M Martinko; Janet M Connolly
Biased T cell receptor usage by Ld-restricted, tum- peptide-specific cytotoxic T lymphocyte clones.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(3):800-11.
1993: J A Goss; R Pyo; M Wayne Flye; Janet M Connolly; Ted H Hansen
Major histocompatibility complex-specific prolongation of murine skin and cardiac allograft survival after in vivo depletion of V beta+ T cells.
The Journal of experimental medicine 1993;177(1):35-44.
1991: Ronald J Rubocki; Janet M Connolly; Ted H Hansen; R W Melvold; B S Kim; W H Hildebrand; J Martinko
Mutation at amino acid position 133 of H-2Dd prevents beta 2m association and immune recognition but not surface expression.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2352-7.
1991: M A Alexander; C A Damico; K M Wieties; Ted H Hansen; Janet M Connolly
Correlation between CD8 dependency and determinant density using peptide-induced, Ld-restricted cytotoxic T lymphocytes.
The Journal of experimental medicine 1991;173(4):849-58.
1991: W R Lie; Nancy Myers; Janet M Connolly; J Gorka; David R Lee; Ted H Hansen
The specific binding of peptide ligand to Ld class I major histocompatibility complex molecules determines their antigenic structure.
The Journal of experimental medicine 1991;173(2):449-59.
1990: W R Lie; Nancy Myers; J Gorka; Ronald J Rubocki; Janet M Connolly; Ted H Hansen
Peptide ligand-induced conformation and surface expression of the Ld class I MHC molecule.
Nature 1990;344(6265):439-41.
1990: Janet M Connolly; Ted H Hansen; A L Ingold; T A Potter
Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(6):2137-41.
1989: J Beck Keeney; M Hedayat; N M Myers; Janet M Connolly; Ted H Hansen
Locus-specific regulation of Kd, Dd, and Ld class I genes in the BALB/c S49 lymphoma sublines.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(7):2364-73.
1988: Janet M Connolly; T A Potter; E M Wormstall; Ted H Hansen
The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses.
The Journal of experimental medicine 1988;168(1):325-41.