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Kirk Conrad

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Kirk P Conrad; Valerie L Baker
Corpus luteal contribution to maternal pregnancy physiology and outcomes in assisted reproductive technologies.
Mark S Segal; Alexander I Agoulnik; YanPeng Diao; Maria B Grant; Jennifer Kielczewski; Shiyu Li; Jonathan McGuane; Laura Sautina; Kirk P Conrad
Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice.
Kirk P Conrad; Sanjeev G Shroff
Effects of relaxin on arterial dilation, remodeling, and mechanical properties.

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All Publications

2013: Kirk P Conrad; Valerie L Baker
Corpus luteal contribution to maternal pregnancy physiology and outcomes in assisted reproductive technologies.
American journal of physiology. Regulatory, integrative and comparative physiology 2013;304(2):R69-72.
2012: Mark S Segal; Alexander I Agoulnik; YanPeng Diao; Maria B Grant; Jennifer Kielczewski; Shiyu Li; Jonathan McGuane; Laura Sautina; Kirk P Conrad
Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice.
Blood 2012;119(2):629-36.
2011: Kirk P Conrad; Sanjeev G Shroff
Effects of relaxin on arterial dilation, remodeling, and mechanical properties.
Current hypertension reports 2011;13(6):409-20.
2011: Kirk P Conrad
Maternal vasodilation in pregnancy: the emerging role of relaxin.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;301(2):R267-75.
2011: Jonathan McGuane; Jacqueline Novak; J Peter Rubin; Laura Sautina; Mark Segal; Julianna E Debrah; Maria B Grant; Yagna P R Jarajapu; Kirk P Conrad
Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide.
Endocrinology 2011;152(7):2786-96.
2011: Dan O Debrah; Julianna E Debrah; Jamie L Haney; Jonathan McGuane; Michael S Sacks; Kirk P Conrad; Sanjeev G Shroff
Relaxin regulates vascular wall remodeling and passive mechanical properties in mice.
Journal of applied physiology (Bethesda, Md. : 1985) 2011;111(1):260-71.
2011: Jonathan McGuane; Leslie A Danielson; Julianna E Debrah; J Peter Rubin; Jacqueline Novak; Kirk P Conrad
Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans.
Hypertension 2011;57(6):1151-60.
2011: Sandra A Founds; Lauren A Terhorst; Kirk P Conrad; W Allen Hogge; Arun Jeyabalan; Yvette P Conley
Gene expression in first trimester preeclampsia placenta.
Biological research for nursing 2011;13(2):134-9.
2010: Kirk P Conrad
Unveiling the vasodilatory actions and mechanisms of relaxin.
Hypertension 2010;56(1):2-9.
2009: Jonathan McGuane; Julianna E Debrah; Dan O Debrah; J Peter Rubin; Mark Segal; Sanjeev G Shroff; Kirk P Conrad
Role of relaxin in maternal systemic and renal vascular adaptations during gestation.
Annals of the New York Academy of Sciences 2009;1160():304-12.
2008: Augustine Rajakumar; H M Michael; Ashi Daftary; Arundhathi Jeyabalan; C Gilmour; Kirk P Conrad
Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteins.
Placenta 2008;29(3):290-9.
2007: Augustine Rajakumar; Arundhathi Jeyabalan; Nina Markovic; Roberta B Ness; Carol Gilmour; Kirk P Conrad
Placental HIF-1 alpha, HIF-2 alpha, membrane and soluble VEGF receptor-1 proteins are not increased in normotensive pregnancies complicated by late-onset intrauterine growth restriction.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(2):R766-74.
2007: Arundhathi Jeyabalan; Sanjeev G Shroff; Jaqueline Novak; Kirk P Conrad
The vascular actions of relaxin.
Advances in experimental medicine and biology 2007;612():65-87.
2007: Arundhathi Jeyabalan; Kirk P Conrad
Renal function during normal pregnancy and preeclampsia.
Frontiers in bioscience : a journal and virtual library 2007;12():2425-37.
2007: Arundhathi Jeyabalan; Jacqueline Novak; Ketah D Doty; Julianna Matthews; Michelle C Fisher; Laurie J Kerchner; Kirk P Conrad
Vascular matrix metalloproteinase-9 mediates the inhibition of myogenic reactivity in small arteries isolated from rats after short-term administration of relaxin.
Endocrinology 2007;148(1):189-97.
2006: Jacqueline Novak; Laura J Parry; Julianna E Matthews; Laurie J Kerchner; Kimberly Indovina; Karen Hanley-Yanez; Ketah D Doty; Dan O Debrah; Sanjeev G Shroff; Kirk P Conrad
Evidence for local relaxin ligand-receptor expression and function in arteries.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(13):2352-62.
2006: Marie Smith; Lee A Danielson; Kirk P Conrad; John M Davison
Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers.
Journal of the American Society of Nephrology : JASN 2006;17(11):3192-7.
2006: Dan O Debrah; Jacqueline Novak; Julianna E Matthews; Rolando J J Ramirez; Sanjeev G Shroff; Kirk P Conrad
Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats.
Endocrinology 2006;147(11):5126-31.
2006: Marie Smith; Alison Murdoch; Lee A Danielson; Kirk P Conrad; John M Davison
Relaxin has a role in establishing a renal response in pregnancy.
Fertility and sterility 2006;86(1):253-5.
2006: Arundhathi Jeyabalan; Laurie J Kerchner; Michelle C Fisher; Jonathan McGuane; Ketah D Doty; Kirk P Conrad
Matrix metalloproteinase-2 activity, protein, mRNA, and tissue inhibitors in small arteries from pregnant and relaxin-treated nonpregnant rats.
Journal of applied physiology (Bethesda, Md. : 1985) 2006;100(6):1955-63.
2006: Augustine Rajakumar; Ketah D Doty; Ashi Daftary; Nina Markovic; Kirk P Conrad
Expression of von Hippel Lindau (pVHL) protein in placentae from normal pregnant women and women with preeclampsia.
Placenta 2006;27(4-5):411-21.
2005: Dan O Debrah; Kirk P Conrad; Arundhathi Jeyabalan; Lee A Danielson; Sanjeev G Shroff
Relaxin increases cardiac output and reduces systemic arterial load in hypertensive rats.
Hypertension 2005;46(4):745-50.
2005: Laurie J Kerchner; Jacqueline Novak; Karen Hanley-Yanez; Ketah D Doty; Lee A Danielson; Kirk P Conrad
Evidence against the hypothesis that endothelial endothelin B receptor expression is regulated by relaxin and pregnancy.
Endocrinology 2005;146(6):2791-7.
2005: Dan O Debrah; Kirk P Conrad; Jacqueline Novak; Lee A Danielson; Sanjeev G Shroff
Recombinant human relaxin (rhRLX) modifies systemic arterial properties in conscious rats irrespective of gender, but in a biphasic fashion.
Annals of the New York Academy of Sciences 2005;1041():155-62.
2005: Kirk P Conrad; Arundhathi Jeyabalan; Lee A Danielson; Laurie J Kerchner; Jacqueline Novak
Role of relaxin in maternal renal vasodilation of pregnancy.
Annals of the New York Academy of Sciences 2005;1041():147-54.
2005: Dan O Debrah; Kirk P Conrad; Lee A Danielson; Sanjeev G Shroff
Effects of relaxin on systemic arterial hemodynamics and mechanical properties in conscious rats: sex dependency and dose response.
Journal of applied physiology (Bethesda, Md. : 1985) 2005;98(3):1013-20.
2005: Kirk P Conrad; Jacqueline Novak; Lee A Danielson; Laurie J Kerchner; Arundhathi Jeyabalan
Mechanisms of renal vasodilation and hyperfiltration during pregnancy: current perspectives and potential implications for preeclampsia.
Endothelium : journal of endothelial cell research 2005;12(1-2):57-62.
2004: Augustine Rajakumar; H M Brandon; Ashi Daftary; Roberta B Ness; Kirk P Conrad
Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae.
Placenta 2004;25(10):763-9.
2004: Kirk P Conrad
Mechanisms of renal vasodilation and hyperfiltration during pregnancy.
Journal of the Society for Gynecologic Investigation 2004;11(7):438-48.
2004: John M Davison; Volker Homuth; Arundhathi Jeyabalan; Kirk P Conrad; S Ananth Karumanchi; Susan E Quaggin; Ralf Dechend; Friedrich C Luft
New aspects in the pathophysiology of preeclampsia.
Journal of the American Society of Nephrology : JASN 2004;15(9):2440-8.
2004: Kirk P Conrad; Jacqueline Novak
Emerging role of relaxin in renal and cardiovascular function.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;287(2):R250-61.
2004: Jacqueline Novak; Augustine Rajakumar; Theresa M Miles; Kirk P Conrad
Nitric oxide synthase isoforms in the rat kidney during pregnancy.
Journal of the Society for Gynecologic Investigation 2004;11(5):280-8.
2004: Kirk P Conrad; Dan O Debrah; Jacqueline Novak; Lee A Danielson; Sanjeev G Shroff
Relaxin modifies systemic arterial resistance and compliance in conscious, nonpregnant rats.
Endocrinology 2004;145(7):3289-96.
2004: Robert W Powers; Alana K Majors; Laurie J Kerchner; Kirk P Conrad
Renal handling of homocysteine during normal pregnancy and preeclampsia.
Journal of the Society for Gynecologic Investigation 2004;11(1):45-50.
2003: Arundhathi Jeyabalan; Jacqueline Novak; Lee A Danielson; Laurie J Kerchner; Shannon L Opett; Kirk P Conrad
Essential role for vascular gelatinase activity in relaxin-induced renal vasodilation, hyperfiltration, and reduced myogenic reactivity of small arteries.
Circulation research 2003;93(12):1249-57.
2003: Lee A Danielson; Kirk P Conrad
Time course and dose response of relaxin-mediated renal vasodilation, hyperfiltration, and changes in plasma osmolality in conscious rats.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;95(4):1509-14.
2003: Augustine Rajakumar; Ketah D Doty; Ashi Daftary; Gail Harger; Kirk P Conrad
Impaired oxygen-dependent reduction of HIF-1alpha and -2alpha proteins in pre-eclamptic placentae.
Placenta 2003;24(2-3):199-208.
2002: Jacqueline Novak; Rolando J J Ramirez; Robin E Gandley; David Orrin Sherwood; Kirk P Conrad
Myogenic reactivity is reduced in small renal arteries isolated from relaxin-treated rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;283(2):R349-55.
2002: Kirk P Conrad; Robert W Powers; Alan K Davis; Jacqueline Novak
Citrulline is not the major product using the standard "NOS activity" assay on renal cortical homogenates.
American journal of physiology. Regulatory, integrative and comparative physiology 2002;282(1):R303-10.
2001: DF Benyo; A Smarason; C W Redman; C Sims; Kirk P Conrad
Expression of inflammatory cytokines in placentas from women with preeclampsia.
The Journal of clinical endocrinology and metabolism 2001;86(6):2505-12.
2001: Jacqueline Novak; Lee A Danielson; Laurie J Kerchner; David Orrin Sherwood; Rolando J J Ramirez; Pamela A Moalli; Kirk P Conrad
Relaxin is essential for renal vasodilation during pregnancy in conscious rats.
The Journal of clinical investigation 2001;107(11):1469-75.
2001: Augustine Rajakumar; K A Whitelock; Lisa A Weissfeld; Ashi Daftary; Nina Markovic; Kirk P Conrad
Selective overexpression of the hypoxia-inducible transcription factor, HIF-2alpha, in placentas from women with preeclampsia.
Biology of reproduction 2001;64(2):499-506.
2001: Robin E Gandley; Kirk P Conrad; Margaret K McLaughlin
Endothelin and nitric oxide mediate reduced myogenic reactivity of small renal arteries from pregnant rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(1):R1-7.
2000: Lee A Danielson; L J Kercher; Kirk P Conrad
Impact of gender and endothelin on renal vasodilation and hyperfiltration induced by relaxin in conscious rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(4):R1298-304.
2000: Augustine Rajakumar; Kirk P Conrad
Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta.
Biology of reproduction 2000;63(2):559-69.
1999: Kirk P Conrad; Laurie J Kerchner; M D Mosher
Plasma and 24-h NO(x) and cGMP during normal pregnancy and preeclampsia in women on a reduced NO(x) diet.
The American journal of physiology 1999;277(1 Pt 2):F48-57.
1999: Kirk P Conrad; Robin E Gandley; Teruyuki Ogawa; S Nakanishi; Lee A Danielson
Endothelin mediates renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats.
The American journal of physiology 1999;276(5 Pt 2):F767-76.
1999: D Fairchild Benyo; Kirk P Conrad
Expression of the erythropoietin receptor by trophoblast cellsin the human placenta.
Biology of reproduction 1999;60(4):861-70.
1999: Lee A Danielson; David Orrin Sherwood; Kirk P Conrad
Relaxin is a potent renal vasodilator in conscious rats.
The Journal of clinical investigation 1999;103(4):525-33.
1998: Kirk P Conrad; Theresa M Miles; DF Benyo
Circulating levels of immunoreactive cytokines in women with preeclampsia.
American journal of reproductive immunology (New York, N.Y. : 1989) 1998;40(2):102-11.
1997: Robin E Gandley; K C Griggs; Kirk P Conrad; Margaret K McLaughlin
Intrinsic tone and passive mechanics of isolated renal arteries from virgin and late-pregnant rats.
The American journal of physiology 1997;273(1 Pt 2):R22-7.
1997: DF Benyo; Theresa M Miles; Kirk P Conrad
Hypoxia stimulates cytokine production by villous explants from the human placenta.
The Journal of clinical endocrinology and metabolism 1997;82(5):1582-8.
1997: Kirk P Conrad; DF Benyo
Placental cytokines and the pathogenesis of preeclampsia.
American journal of reproductive immunology (New York, N.Y. : 1989) 1997;37(3):240-9.
1997: S M Sladek; R R Magness; Kirk P Conrad
Nitric oxide and pregnancy.
The American journal of physiology 1997;272(2 Pt 2):R441-63.
1996: Lee A Danielson; Kirk P Conrad
Prostaglandins maintain renal vasodilation and hyperfiltration during chronic nitric oxide synthase blockade in conscious pregnant rats.
Circulation research 1996;79(6):1161-6.
1996: Kirk P Conrad; DF Benyo; A Westerhausen-Larsen; T M Miles
Expression of erythropoietin by the human placenta.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(7):760-8.
1995: Kirk P Conrad; A K Davis
Nitric oxide synthase activity in placentae from women with pre-eclampsia.
Placenta 1995;16(8):691-9.
1995: Lee A Danielson; Kirk P Conrad
Acute blockade of nitric oxide synthase inhibits renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats.
The Journal of clinical investigation 1995;96(1):482-90.
1995: S R Gough; M D Mosher; Kirk P Conrad
Metabolism of erythropoietin in conscious pregnant rats.
The American journal of physiology 1995;268(5 Pt 2):R1117-20.
1995: Margaret K McLaughlin; Kirk P Conrad
Nitric oxide biosynthesis during pregnancy: implications for circulatory changes.
Clinical and experimental pharmacology & physiology 1995;22(2):164-71.
1994: Kirk P Conrad; M D Mosher; T Brinck-Johnsen; M C Colpoys
Effects of 17 beta-estradiol and progesterone on pressor responses in conscious ovariectomized rats.
The American journal of physiology 1994;266(4 Pt 2):R1267-72.
1993: Kirk P Conrad; M Vill; P G McGuire; WG Dail; A K Davis
Expression of nitric oxide synthase by syncytiotrophoblast in human placental villi.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(13):1269-76.
1993: G O Del Valle; M D Mosher; Kirk P Conrad
Serum immunoreactive erythropoietin and red blood cell mass during pregnancy in conscious rats.
The American journal of physiology 1993;265(2 Pt 2):R399-403.
1993: K C Griggs; Kirk P Conrad; K Mackey; Margaret K McLaughlin
Endothelial modulation of renal interlobar arteries from pregnant rats.
The American journal of physiology 1993;265(2 Pt 2):F309-15.
1993: Kirk P Conrad; M Gellai; William G North; H Valtin
Influence of oxytocin on renal hemodynamics and sodium excretion.
Annals of the New York Academy of Sciences 1993;689():346-62.
1993: Kirk P Conrad; G M Joffe; Harriet G Kruszyna; R Kruszyna; L G Rochelle; Roger P Smith; J E Chavez; M D Mosher
Identification of increased nitric oxide biosynthesis during pregnancy in rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(6):566-71.
1992: G J Gilson; M D Mosher; Kirk P Conrad
Systemic hemodynamics and oxygen transport during pregnancy in chronically instrumented, conscious rats.
The American journal of physiology 1992;263(6 Pt 2):H1911-8.
1992: Kirk P Conrad; S L Whittemore
NG-monomethyl-L-arginine and nitroarginine potentiate pressor responsiveness of vasoconstrictors in conscious rats.
The American journal of physiology 1992;262(6 Pt 2):R1137-44.
1992: Kirk P Conrad; R D Russ
Augmentation of baroreflex-mediated bradycardia in conscious pregnant rats.
The American journal of physiology 1992;262(3 Pt 2):R472-7.
1991: Kirk P Conrad; S A Barrera; Peter A Friedman; V M Schmidt
Evidence for attenuation of myo-inositol uptake, phosphoinositide turnover and inositol phosphate production in aortic vasculature of rats during pregnancy.
The Journal of clinical investigation 1991;87(5):1700-9.
1991: M A Brandt; Kirk P Conrad
In vivo and in vitro studies of a putative inhibitor of cyclic guanosine 3',5'-monophosphate production.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1991;196(1):30-5.
1989: Kirk P Conrad; K A Vernier
Plasma level, urinary excretion, and metabolic production of cGMP during gestation in rats.
The American journal of physiology 1989;257(4 Pt 2):R847-53.
1989: Kirk P Conrad; P M Morganelli; T Brinck-Johnsen; M C Colpoys
The renin-angiotensin system during pregnancy in chronically instrumented, conscious rats.
American journal of obstetrics and gynecology 1989;161(4):1065-72.
1986: Kirk P Conrad; M Gellai; William G North; H Valtin
Influence of oxytocin on renal hemodynamics and electrolyte and water excretion.
The American journal of physiology 1986;251(2 Pt 2):F290-6.
1986: Kirk P Conrad; M C Colpoys
Evidence against the hypothesis that prostaglandins are the vasodepressor agents of pregnancy. Serial studies in chronically instrumented, conscious rats.
The Journal of clinical investigation 1986;77(1):236-45.
1984: Kirk P Conrad; T Brinck-Johnsen; M Gellai; H Valtin
Renal autoregulation in chronically catheterized conscious rats.
The American journal of physiology 1984;247(2 Pt 2):F229-33.