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Rudolf Allemann

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Jian-Xu Li; David J Miller; Ju-Xin Ruan; Ling-Jian Wang; Chang-Qing Yang; Rudolf K Allemann; Xiao-Ya Chen; Xin Fang; Juan A Faraldos; Qin Zhao; Peng Zhang
Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency.
E Joel Loveridge; Stella M Matthews; Sara B-M Whittaker; Christopher Williams; Matthew P Crump; William M Dawson; Rhiannon M Evans; Ulrich L Günther; Rudolf K Allemann
Aliphatic (1)H, (13)C and (15)N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda in complex with NADP(+) and folate.
Juan A Faraldos; Veronica Gonzalez; Mustafa Köksal; Amang Li; Fanglei Yu; David W Christianson; Rudolf K Allemann
Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases.

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2013: Jian-Xu Li; David J Miller; Ju-Xin Ruan; Ling-Jian Wang; Chang-Qing Yang; Rudolf K Allemann; Xiao-Ya Chen; Xin Fang; Juan A Faraldos; Qin Zhao; Peng Zhang
Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency.
The Biochemical journal 2013;451(3):417-26.
2013: E Joel Loveridge; Stella M Matthews; Sara B-M Whittaker; Christopher Williams; Matthew P Crump; William M Dawson; Rhiannon M Evans; Ulrich L Günther; Rudolf K Allemann
Aliphatic (1)H, (13)C and (15)N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda in complex with NADP(+) and folate.
Biomolecular NMR assignments 2013;7(1):61-4.
2012: Juan A Faraldos; Veronica Gonzalez; Mustafa Köksal; Amang Li; Fanglei Yu; David W Christianson; Rudolf K Allemann
Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases.
Journal of the American Chemical Society 2012;134(51):20844-8.
2012: Oscar Cascón; Juan A Faraldos; Veronica Gonzalez; David J Miller; Sabrina Touchet; Rudolf K Allemann
Chemoenzymatic preparation of germacrene analogues.
Chemical communications (Cambridge, England) 2012;48(78):9702-4.
2012: Zulfa Yoosuf-Aly; Juan A Faraldos; David J Miller; Rudolf K Allemann
Chemoenzymatic synthesis of the alarm pheromone (+)-verbenone from geranyl diphosphate.
Chemical communications (Cambridge, England) 2012;48(56):7040-2.
2012: Piotr Wysoczanski; Matthew P Crump; E Joel Loveridge; Robert J Mart; Sara B-M Whittaker; Christopher Williams; Rudolf K Allemann
NMR solution structure of a photoswitchable apoptosis activating Bak peptide bound to Bcl-xL.
Journal of the American Chemical Society 2012;134(18):7644-7.
2012: Juan A Faraldos; Verónica González; Amang Li; David J Miller; Zulfa Yoosuf-Aly; Oscar Cascón; Rudolf K Allemann
A 1,6-ring closure mechanism for (+)-δ-cadinene synthase?
Journal of the American Chemical Society 2012;134(13):5900-8.
2012: E Joel Loveridge; Enas M Behiry; Jiannan Guo; Rudolf K Allemann
Evidence that a 'dynamic knockout' in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis.
Nature chemistry 2012;4(4):292-7.
2012: Danilo Aros; Veronica Gonzalez; Carsten T Müller; Rudolf K Allemann; Carlo Rosati; Hilary J Rogers
Volatile emissions of scented Alstroemeria genotypes are dominated by terpenes, and a myrcene synthase gene is highly expressed in scented Alstroemeria flowers.
Journal of experimental botany 2012;63(7):2739-52.
2012: Juan A Faraldos; Veronica Gonzalez; Rudolf K Allemann
The role of aristolochene synthase in diphosphate activation.
Chemical communications (Cambridge, England) 2012;48(26):3230-2.
2012: Robert J Mart; Antonio Ricci; Piotr Wysoczański; Andrea Brancale; Sabine Kneißl; Rudolf K Allemann
Design of photocontrolled RNA-binding peptidomimetics.
Chembiochem : a European journal of chemical biology 2012;13(4):515-9.
2011: E Joel Loveridge; Anna Sobolewska; William M Dawson; Rhiannon M Evans; Rudolf K Allemann
Reduced susceptibility of Moritella profunda dihydrofolate reductase to trimethoprim is not due to glutamate 28.
The protein journal 2011;30(8):546-8.
2011: Juan A Faraldos; Verónica González; Michael Senske; Rudolf K Allemann
Templating effects in aristolochene synthase catalysis: elimination versus cyclisation.
Organic & biomolecular chemistry 2011;9(20):6920-3.
2011: Thomas Fricke; Arwyn T Jones; Robert J Mart; Paul J Smith; Catherine L Watkins; Marie Wiltshire; Rachel J Errington; Rudolf K Allemann
Chemical synthesis of cell-permeable apoptotic peptides from in vivo produced proteins.
Bioconjugate chemistry 2011;22(9):1763-7.
2011: Juan A Faraldos; Rebecca Fullerton; Verónica González; Eric M Tippmann; Alicja K Antonczak; Rudolf K Allemann
Probing eudesmane cation-π interactions in catalysis by aristolochene synthase with non-canonical amino acids.
Journal of the American Chemical Society 2011;133(35):13906-9.
2011: E Joel Loveridge; Rudolf K Allemann
Effect of pH on hydride transfer by Escherichia coli dihydrofolate reductase.
Chembiochem : a European journal of chemical biology 2011;12(8):1258-62.
2011: Juan A Faraldos; Rudolf K Allemann
Inhibition of (+)-aristolochene synthase with iminium salts resembling eudesmane cation.
Organic letters 2011;13(5):1202-5.
2010: Rhiannon M Evans; Enas M Behiry; Lai-hock Tey; Jiannan Guo; E Joel Loveridge; Rudolf K Allemann
Catalysis by dihydrofolate reductase from the psychropiezophile Moritella profunda.
Chembiochem : a European journal of chemical biology 2010;11(14):2010-7.
2010: E Joel Loveridge; Rudolf K Allemann
The temperature dependence of the kinetic isotope effects of dihydrofolate reductase from Thermotoga maritima is influenced by intersubunit interactions.
Biochemistry 2010;49(25):5390-6.
2010: Juan A Faraldos; Benson M Kariuki; Rudolf K Allemann
Intermediacy of eudesmane cation during catalysis by aristolochene synthase.
The Journal of organic chemistry 2010;75(4):1119-25.
2010: E Joel Loveridge; Lai-hock Tey; Rudolf K Allemann
Solvent effects on catalysis by Escherichia coli dihydrofolate reductase.
Journal of the American Chemical Society 2010;132(3):1137-43.
2009: E Joel Loveridge; Giovanni Maglia; Rudolf K Allemann
The role of arginine 28 in catalysis by dihydrofolate reductase from the hyperthermophile Thermotoga maritima.
Chembiochem : a European journal of chemical biology 2009;10(16):2624-7.
2009: Sam Hay; Rhiannon M Evans; Colin Levy; E Joel Loveridge; Xi Wang; David Leys; Rudolf K Allemann; Nigel S Scrutton
Are the catalytic properties of enzymes from piezophilic organisms pressure adapted?
Chembiochem : a European journal of chemical biology 2009;10(14):2348-53.
2009: Heather A Gennadios; Veronica Gonzalez; Luigi Di Costanzo; Amang Li; Fanglei Yu; David J Miller; Rudolf K Allemann; David W Christianson
Crystal structure of (+)-delta-cadinene synthase from Gossypium arboreum and evolutionary divergence of metal binding motifs for catalysis.
Biochemistry 2009;48(26):6175-83.
2009: E Joel Loveridge; Robert J Rodriguez; Richard S Swanwick; Rudolf K Allemann
Effect of dimerization on the stability and catalytic activity of dihydrofolate reductase from the hyperthermophile Thermotoga maritima.
Biochemistry 2009;48(25):5922-33.
2009: E Joel Loveridge; Enas M Behiry; Richard S Swanwick; Rudolf K Allemann
Different reaction mechanisms for mesophilic and thermophilic dihydrofolate reductases.
Journal of the American Chemical Society 2009;131(20):6926-7.
2009: Rudolf K Allemann; Rhiannon M Evans; E Joel Loveridge
Probing coupled motions in enzymatic hydrogen tunnelling reactions.
Biochemical Society transactions 2009;37(Pt 2):349-53.
2009: David J Miller; Fanglei Yu; David W Knight; Rudolf K Allemann
6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase.
Organic & biomolecular chemistry 2009;7(5):962-75.
2008: sam hay; Jiayun Pang; Phillip J Monaghan; Xi Wang; Rhiannon M Evans; Michael J Sutcliffe; Rudolf K Allemann; Nigel S Scrutton
Secondary kinetic isotope effects as probes of environmentally-coupled enzymatic hydrogen tunneling reactions.
Chemphyschem : a European journal of chemical physics and physical chemistry 2008;9(11):1536-9.
2008: Wayne R Edwards; Kathy Busse; Rudolf K Allemann; D Dafydd Jones
Linking the functions of unrelated proteins using a novel directed evolution domain insertion method.
Nucleic acids research 2008;36(13):e78.
2008: David J Miller; Jiali Gao; Donald G Truhlar; Neil J Young; Veronica Gonzalez; Rudolf K Allemann
Stereochemistry of eudesmane cation formation during catalysis by aristolochene synthase from Penicillium roqueforti.
Organic & biomolecular chemistry 2008;6(13):2346-54.
2008: Ekaterina Y Shishova; Fanglei Yu; David J Miller; Juan A Faraldos; Yuxin Zhao; Robert M Coates; Rudolf K Allemann; David E Cane; David W Christianson
X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis.
The Journal of biological chemistry 2008;283(22):15431-9.
2008: Klaus Fütterer; Raimond B G Ravelli; Scott A White; Andrew J Nicoll; Rudolf K Allemann
Differential specific radiation damage in the Cu II-bound and Pd II-bound forms of an alpha-helical foldamer: a case study of crystallographic phasing by RIP and SAD.
Acta crystallographica. Section D, Biological crystallography 2008;64(Pt 3):264-72.
2008: E Joel Loveridge; Rhiannon M Evans; Rudolf K Allemann
Solvent effects on environmentally coupled hydrogen tunnelling during catalysis by dihydrofolate reductase from Thermotoga maritima.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(34):10782-8.
2007: Rudolf K Allemann; Neil J Young; Shuhua Ma; Donald G Truhlar; Jiali Gao
Synthetic efficiency in enzyme mechanisms involving carbocations: aristolochene synthase.
Journal of the American Chemical Society 2007;129(43):13008-13.
2007: Fanglei Yu; David J Miller; Rudolf K Allemann
Probing the reaction mechanism of aristolochene synthase with 12,13-difluorofarnesyl diphosphate.
Chemical communications (Cambridge, England) 2007;(40):4155-7.
2007: David J Miller; Fanglei Yu; Neil J Young; Rudolf K Allemann
Competitive inhibition of aristolochene synthase by phenyl-substituted farnesyl diphosphates: evidence of active site plasticity.
Organic & biomolecular chemistry 2007;5(20):3287-98.
2007: David J Miller; Fanglei Yu; Rudolf K Allemann
Aristolochene synthase-catalyzed cyclization of 2-fluorofarnesyl-diphosphate to 2-fluorogermacrene A.
Chembiochem : a European journal of chemical biology 2007;8(15):1819-25.
2007: Jiayun Pang; Rudolf K Allemann
Molecular dynamics simulation of thermal unfolding of Thermatoga maritima DHFR.
Physical chemistry chemical physics : PCCP 2007;9(6):711-8.
2007: D J Miller; Rudolf K Allemann
myo-Inositol monophosphatase: a challenging target for mood stabilising drugs.
Mini reviews in medicinal chemistry 2007;7(2):107-13.
2006: Rudolf K Allemann; Rhiannon M Evans; Lai-hock Tey; Giovanni Maglia; Jiayun Pang; Robert Rodriguez; Paul J Shrimpton; Richard S Swanwick
Protein motions during catalysis by dihydrofolate reductases.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2006;361(1472):1317-21.
2006: Andrew J Nicoll; David J Miller; Klaus Fütterer; Raymond Ravelli; Rudolf K Allemann
Designed high affinity Cu2+-binding alpha-helical foldamer.
Journal of the American Chemical Society 2006;128(28):9187-93.
2006: Silvia Forcat; Rudolf K Allemann
Stabilisation of transition states prior to and following eudesmane cation in aristolochene synthase.
Organic & biomolecular chemistry 2006;4(13):2563-7.
2006: Jiayun Pang; Jingzhi Pu; Jiali Gao; Donald G Truhlar; Rudolf K Allemann
Hydride transfer reaction catalyzed by hyperthermophilic dihydrofolate reductase is dominated by quantum mechanical tunneling and is promoted by both inter- and intramonomeric correlated motions.
Journal of the American Chemical Society 2006;128(24):8015-23.
2006: Richard S Swanwick; Giovanni Maglia; Lai-hock Tey; Rudolf K Allemann
Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase.
The Biochemical journal 2006;394(Pt 1):259-65.
2005: Andrew J Nicoll; Chris J Weston; Charley Cureton; Christian Ludwig; Felican Dancea; Neil Spencer; Oliver S Smart; Ulrich L Günther; Rudolf K Allemann
De novo design of a stable N-terminal helical foldamer.
Organic & biomolecular chemistry 2005;3(24):4310-5.
2005: Lucia Guerrero; Oliver S Smart; Chris J Weston; Darcy C Burns; andrew woolley; Rudolf K Allemann
Photochemical regulation of DNA-binding specificity of MyoD.
Angewandte Chemie (International ed. in English) 2005;44(47):7778-82.
2005: Lucia Guerrero; Oliver S Smart; andrew woolley; Rudolf K Allemann
Photocontrol of DNA binding specificity of a miniature engrailed homeodomain.
Journal of the American Chemical Society 2005;127(44):15624-9.
2005: Richard S Swanwick; Alison M Daines; Lai-hock Tey; Sabine L Flitsch; Rudolf K Allemann
Increased thermal stability of site-selectively glycosylated dihydrofolate reductase.
Chembiochem : a European journal of chemical biology 2005;6(8):1338-40.
2005: Richard S Swanwick; Alison M Daines; Sabine L Flitsch; Rudolf K Allemann
Synthesis of homogenous site-selectively glycosylated proteins.
Organic & biomolecular chemistry 2005;3(4):572-4.
2004: Silvia Forcat; Rudolf K Allemann
Dual role for phenylalanine 178 during catalysis by aristolochene synthase.
Chemical communications (Cambridge, England) 2004;(18):2094-5.
2004: Andrew J Nicoll; Rudolf K Allemann
Nucleophilic and general acid catalysis at physiological pH by a designed miniature esterase.
Organic & biomolecular chemistry 2004;2(15):2175-80.
2004: Chris J Weston; Charly H Cureton; Melanie J Calvert; Oliver S Smart; Rudolf K Allemann
A stable miniature protein with oxaloacetate decarboxylase activity.
Chembiochem : a European journal of chemical biology 2004;5(8):1075-80.
2004: Richard S Swanwick; Paul J Shrimpton; Rudolf K Allemann
Pivotal role of Gly 121 in dihydrofolate reductase from Escherichia coli: the altered structure of a mutant enzyme may form the basis of its diminished catalytic performance.
Biochemistry 2004;43(14):4119-27.
2004: David J Miller; M Bashir-Uddin Surfraz; Mahmoud Akhtar; David Gani; Rudolf K Allemann
Removal of the phosphate group in mechanism-based inhibitors of inositol monophosphatase leads to unusual inhibitory activity.
Organic & biomolecular chemistry 2004;2(5):671-88.
2004: Elizebeth C Turner; Charlotte H Cureton; Chris J Weston; Oliver S Smart; Rudolf K Allemann
Controlling the DNA binding specificity of bHLH proteins through intramolecular interactions.
Chemistry & biology 2004;11(1):69-77.
2003: Giovanni Maglia; Rudolf K Allemann
Evidence for environmentally coupled hydrogen tunneling during dihydrofolate reductase catalysis.
Journal of the American Chemical Society 2003;125(44):13372-3.
2003: Athina Deligeorgopoulou; Susan E Taylor; Silvia Forcat; Rudolf K Allemann
Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysis.
Chemical communications (Cambridge, England) 2003;(17):2162-3.
2003: Giovanni Maglia; Masood H Javed; Rudolf K Allemann
Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima.
The Biochemical journal 2003;374(Pt 2):529-35.
2003: Athina Deligeorgopoulou; Rudolf K Allemann
Evidence for differential folding of farnesyl pyrophosphate in the active site of aristolochene synthase: a single-point mutation converts aristolochene synthase into an (E)-beta-farnesene synthase.
Biochemistry 2003;42(25):7741-7.
2003: Rakesh BARGOTA; Mahmoud Akhtar; Keith Biggadike; David Gani; Rudolf K Allemann
Structure-activity relationship on human serum paraoxonase (PON1) using substrate analogues and inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(10):1623-6.
2003: Paul J Shrimpton; Alex Mullaney; Rudolf K Allemann
Functional role for Tyr 31 in the catalytic cycle of chicken dihydrofolate reductase.
Proteins 2003;51(2):216-23.
2002: Melanie J Calvert; Susan E Taylor; Rudolf K Allemann
Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate.
Chemical communications (Cambridge, England) 2002;(20):2384-5.
2002: Melanie J Calvert; Peter R Ashton; Rudolf K Allemann
Germacrene A is a product of the aristolochene synthase-mediated conversion of farnesylpyrophosphate to aristolochene.
Journal of the American Chemical Society 2002;124(39):11636-41.
2002: Paul J Shrimpton; Rudolf K Allemann
Role of water in the catalytic cycle of E. coli dihydrofolate reductase.
Protein science : a publication of the Protein Society 2002;11(6):1442-51.
2001: S E Taylor; T J Rutherford; Rudolf K Allemann
Design, synthesis and characterisation of a peptide with oxaloacetate decarboxylase activity.
Bioorganic & medicinal chemistry letters 2001;11(19):2631-5.
2000: M Sieber; Rudolf K Allemann
Thermodynamics of DNA binding of MM17, a 'single chain dimer' of transcription factor MASH-1.
Nucleic acids research 2000;28(10):2122-7.
1999: C Dezan; D Meierhans; A G Künne; Rudolf K Allemann
Acquisition of myogenic specificity through replacement of one amino acid of MASH-1 and introduction of an additional alpha-helical turn.
Biological chemistry 1999;380(6):705-10.
1998: D Meierhans; Rudolf K Allemann
The N-terminal methionine is a major determinant of the DNA binding specificity of MEF-2C.
The Journal of biological chemistry 1998;273(40):26052-60.
1998: M Sieber; Rudolf K Allemann
Arginine (348) is a major determinant of the DNA binding specificity of transcription factor E12.
Biological chemistry 1998;379(6):731-5.
1998: A G K-unne; M Sieber; D Meierhans; Rudolf K Allemann
Thermodynamics of the DNA binding reaction of transcription factor MASH-1.
Biochemistry 1998;37(12):4217-23.
1998: M Sieber; Rudolf K Allemann
Single chain dimers of MASH-1 bind DNA with enhanced affinity.
Nucleic acids research 1998;26(6):1408-13.
1997: D Meierhans; Rudolf K Allemann
High level expression in soluble form, one step purification, and characterization of the DNA binding domain of MEF-2C.
Protein expression and purification 1997;11(3):297-303.
1997: D Meierhans; M Sieber; Rudolf K Allemann
High affinity binding of MEF-2C correlates with DNA bending.
Nucleic acids research 1997;25(22):4537-44.
1997: Rudolf K Allemann; M Egli
DNA recognition and bending.
Chemistry & biology 1997;4(9):643-50.
1997: A G Künne; Rudolf K Allemann
Covalently linking BHLH subunits of MASH-1 increases specificity of DNA binding.
Biochemistry 1997;36(5):1085-91.
1996: A G Künne; D Meierhans; Rudolf K Allemann
Basic helix-loop-helix protein MyoD displays modest DNA binding specificity.
FEBS letters 1996;391(1-2):79-83.
1995: D Meierhan; C el-Ariss; M Neuenschwander; M Sieber; J F Stackhouse; Rudolf K Allemann
DNA binding specificity of the basic-helix-loop-helix protein MASH-1.
Biochemistry 1995;34(35):11026-36.
1993: K Johnsson; Rudolf K Allemann; Hans Widmer; S A Benner
Synthesis, structure and activity of artificial, rationally designed catalytic polypeptides.
Nature 1993;365(6446):530-2.
1991: Rudolf K Allemann; Scott Presnell; S A Benner
A hybrid of bovine pancreatic ribonuclease and human angiogenin: an external loop as a module controlling substrate specificity?
Protein engineering 1991;4(7):831-5.
1989: S A Benner; Rudolf K Allemann
The return of pancreatic ribonucleases.
Trends in biochemical sciences 1989;14(10):396-7.
1987: S A Benner; Rudolf K Allemann; A D Ellington; L Ge; A Glasfeld; G F Leanz; T Krauch; L J MacPherson; S Moroney; J A Piccirilli
Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry.
Cold Spring Harbor symposia on quantitative biology 1987;52():53-63.