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Stefan Constantinescu

Research Profile

Chemicals & Drugs

Physiology

Living Beings

Mouse

Phenomena

Anatomy

Disorders

Myeloproliferative Disorders

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Genes & Molecular Sequences

Amino Acid Sequences

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Publications

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Adam J Mead; Simon Moule; Christian Pecquet; Michelle Rugless; Anna Schuh; Joannah Score; Paresh Vyas; Petter Woll; Deborah Atkinson; Nicola Bienz; Adam Burns; Onima Chowdhury; Ruth Clifford; Stefan N Constantinescu; Nick Cross; Alexandra Dusa; Rosemary E Gale; Shirley Henderson; Sten Eirik W Jacobsen
Impact of isolated germline JAK2V617I mutation on human hematopoiesis.
Jean-Philippe Defour; Vitalina Gryshkova; Miki Itaya; Christian Pecquet; Takeshi Sato; Steven O Smith; Ian C Brett; Stefan N Constantinescu
Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.
Christian Pecquet; Yohan Royer; Judith Staerk; William Vainchenker; Jean-Luc Villeval; Rodolphe Besancenot; Pierre J Courtoy; Jean-Philippe Defour; Carmen C Diaconu; Alexandra Dusa; Michael Girardot; Stéphane Giraudier; Laurent Knoops; Caroline Marty; Stefan N Constantinescu
Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes.

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All Publications

2013: Adam J Mead; Simon Moule; Christian Pecquet; Michelle Rugless; Anna Schuh; Joannah Score; Paresh Vyas; Petter Woll; Deborah Atkinson; Nicola Bienz; Adam Burns; Onima Chowdhury; Ruth Clifford; Stefan N Constantinescu; Nick Cross; Alexandra Dusa; Rosemary E Gale; Shirley Henderson; Sten Eirik W Jacobsen
Impact of isolated germline JAK2V617I mutation on human hematopoiesis.
Blood 2013;121(20):4156-65.
2013: Jean-Philippe Defour; Vitalina Gryshkova; Miki Itaya; Christian Pecquet; Takeshi Sato; Steven O Smith; Ian C Brett; Stefan N Constantinescu
Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(7):2540-5.
2012: Christian Pecquet; Yohan Royer; Judith Staerk; William Vainchenker; Jean-Luc Villeval; Rodolphe Besancenot; Pierre J Courtoy; Jean-Philippe Defour; Carmen C Diaconu; Alexandra Dusa; Michael Girardot; Stéphane Giraudier; Laurent Knoops; Caroline Marty; Stefan N Constantinescu
Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes.
Blood 2012;119(20):4625-35.
2012: N Ben Khalifa; Stefan N Constantinescu; Pierre J Courtoy; Jean-Noël Octave; Jean-Christophe Renauld; Donatienne Tyteca; Pascal Kienlen-Campard
Contribution of Kunitz protease inhibitor and transmembrane domains to amyloid precursor protein homodimerization.
Neuro-degenerative diseases 2012;10(1-4):92-5.
2011: Judith Staerk; William Vainchenker; Hélène Antoine-Poirel; Ian Brett; Jean-Philippe Defour; Miki Itaya; Emilie Leroy; Christian Pecquet; Steven O Smith; Stefan N Constantinescu
Orientation-specific signalling by thrombopoietin receptor dimers.
The EMBO journal 2011;30(21):4398-413.
2011: Sandrine Medves; Carmen P Montano-Almendras; Laura A Noël; Hélène Schoemans; Roxana I Albu; Stefan N Constantinescu; Jean-Baptiste Demoulin
Multiple oligomerization domains of KANK1-PDGFRβ are required for JAK2-independent hematopoietic cell proliferation and signaling via STAT5 and ERK.
Haematologica 2011;96(10):1406-14.
2011: William Vainchenker; Stefan N Constantinescu; François Delhommeau; Olivier A Bernard
New mutations and pathogenesis of myeloproliferative neoplasms.
Blood 2011;118(7):1723-35.
2011: Tekla Hornakova; Lorraine Springuel; Julien Devreux; Alexandra Dusa; Stefan N Constantinescu; Laurent Knoops; Jean-Christophe Renauld
Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors.
Haematologica 2011;96(6):845-53.
2011: Roxana I Albu; Stefan N Constantinescu
Extracellular domain N-glycosylation controls human thrombopoietin receptor cell surface levels.
Frontiers in endocrinology 2011;2():71.
2010: Naouel Ben Khalifa; Joanne Van Hees; Bernadette Tasiaux; Sandra Huysseune; Steven O Smith; Stefan N Constantinescu; Jean-Noël Octave; Pascal Kienlen-Campard
What is the role of amyloid precursor protein dimerization?
Cell adhesion & migration 2010;4(2):268-72.
2010: Christian Pecquet; Judith Staerk; Ronan Chaligné; Valerie Goss; Kimberly A Lee; Xiaowu Zhang; John Rush; Joanne Van Hees; Hélène A Poirel; Jean-Marie Scheiff; William Vainchenker; Stéphane Giraudier; Roberto D Polakiewicz; Stefan N Constantinescu
Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor.
Blood 2010;115(5):1037-48.
2010: Rodolphe Besancenot; Ronan Chaligné; Carole Tonetti; Florence Pasquier; Caroline Marty; Yann Lécluse; William Vainchenker; Stefan N Constantinescu; Stéphane Giraudier
A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferation.
PLoS biology 2010;8(9):.
2009: Isabelle Plo; Yanyan Zhang; Jean Pierre Le Couédic; Mayuka Nakatake; Jean-Michel Boulet; Miki Itaya; Steven O Smith; Najet Debili; Stefan N Constantinescu; William Vainchenker; Fawzia Louache; Stéphane de Botton
An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia.
The Journal of experimental medicine 2009;206(8):1701-7.
2009: Caroline Marty; Ronan Chaligné; Catherine Lacout; Stefan N Constantinescu; William Vainchenker; Jean-Luc Villeval
Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity.
The Journal of biological chemistry 2009;284(18):11781-91.
2009: Tekla Hornakova; Judith Staerk; Yohan Royer; Elisabetta Flex; Marco Tartaglia; Stefan N Constantinescu; Laurent Knoops; Jean-Christophe Renauld
Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers.
The Journal of biological chemistry 2009;284(11):6773-81.
2009: Takeshi Sato; Tzu Chun Tang; Gabriella Reubins; Jeffrey Z Fei; Taiki Fujimoto; Pascal Kienlen-Campard; Stefan N Constantinescu; Jean-Noël Octave; Saburo Aimoto; Steven O Smith
A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(5):1421-6.
2008: William Vainchenker; Alexandra Dusa; Stefan N Constantinescu
JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies.
Seminars in cell & developmental biology 2008;19(4):385-93.
2008: Laurent Knoops; T Hornakova; Yohan Royer; Stefan N Constantinescu; Jean-Christophe Renauld
JAK kinases overexpression promotes in vitro cell transformation.
Oncogene 2008;27(11):1511-9.
2008: L Knoops; C Hermans; Augustin Ferrant; Stefan N Constantinescu
Clinical implications of JAK2 mutations in myeloproliferative disorders.
Acta clinica Belgica 2008;63(2):93-8.
2008: Stefan N Constantinescu; Michael Girardot; Christian Pecquet
Mining for JAK-STAT mutations in cancer.
Trends in biochemical sciences 2008;33(3):122-31.
2008: Youngkyun Lee; Seok-Won Hyung; Hee Jung Jung; Hyung-Joon Kim; Judith Staerk; Stefan N Constantinescu; Eun-Ju Chang; Zang Hee Lee; Sang-Won Lee; Hong-Hee Kim
The ubiquitin-mediated degradation of Jak1 modulates osteoclastogenesis by limiting interferon-beta-induced inhibitory signaling.
Blood 2008;111(2):885-93.
2007: Michelle B Hookham; Joanne Elliott; Yvonne Suessmuth; Judith Staerk; Alister Ward; William Vainchenker; Melanie J Percy; Mary Frances McMullin; Stefan N Constantinescu; James A Johnston
The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3.
Blood 2007;109(11):4924-9.
2007: Judith Staerk; Anders Kallin; Yohan Royer; C C Diaconu; A Dusa; Jean-Baptiste Demoulin; William Vainchenker; Stefan N Constantinescu
JAK2, the JAK2 V617F mutant and cytokine receptors.
Pathologie-biologie 2007;55(2):88-91.
2006: François Delhommeau; Didier F Pisani; Chloé James; Nicole Casadevall; Stefan N Constantinescu; William Vainchenker
Oncogenic mechanisms in myeloproliferative disorders.
Cellular and molecular life sciences : CMLS 2006;63(24):2939-53.
2006: Takeshi Sato; Pascal Kienlen-Campard; Mahiuddin Ahmed; Wei Liu; Huilin Li; James I Elliott; Saburo Aimoto; Stefan N Constantinescu; Jean-Noel Octave; Steven O Smith
Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.
Biochemistry 2006;45(17):5503-16.
2006: Judith Staerk; Catherine Lacout; Takeshi Sato; Steven O Smith; William Vainchenker; Stefan N Constantinescu
An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor.
Blood 2006;107(5):1864-71.
2005: Judith Staerk; Anders Kallin; Jean-Baptiste Demoulin; William Vainchenker; Stefan N Constantinescu
JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor.
The Journal of biological chemistry 2005;280(51):41893-9.
2005: Chloé James; Valérie Ugo; Nicole Casadevall; Stefan N Constantinescu; William Vainchenker
A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects.
Trends in molecular medicine 2005;11(12):546-54.
2005: Dalila Sekkaï; Gaëtan Gruel; Magali Herry; Virginie Moucadel; Stefan N Constantinescu; Olivier Albagli; Diana Tronik-Le Roux; William Vainchenker; Annelise Bennaceur-Griscelli
Microarray analysis of LIF/Stat3 transcriptional targets in embryonic stem cells.
Stem cells (Dayton, Ohio) 2005;23(10):1634-42.
2005: Zhizhuang Joe Zhao; William Vainchenker; Sanford B Krantz; Nicole Casadevall; Stefan N Constantinescu
Role of tyrosine kinases and phosphatases in polycythemia vera.
Seminars in hematology 2005;42(4):221-9.
2005: Wei Liu; Evan Crocker; Stefan N Constantinescu; Steven O Smith
Helix packing and orientation in the transmembrane dimer of gp55-P of the spleen focus forming virus.
Biophysical journal 2005;89(2):1194-202.
2005: Yohan Royer; Judith Staerk; Marcel Costuleanu; Pierre J Courtoy; Stefan N Constantinescu
Janus kinases affect thrombopoietin receptor cell surface localization and stability.
The Journal of biological chemistry 2005;280(29):27251-61.
2005: Chloé James; Valérie Ugo; Jean Pierre Le Couédic; Judith Staerk; François Delhommeau; Catherine Lacout; Loïc Garçon; Hana Raslova; Roland Berger; Annelise Bennaceur-Griscelli; Jean-Luc Villeval; Stefan N Constantinescu; Nicole Casadevall; William Vainchenker
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.
Nature 2005;434(7037):1144-8.
2005: Katharina F Kubatzky; Wei Liu; Kerri Goldgraben; Carlos Simmerling; Steven O Smith; Stefan N Constantinescu
Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function.
The Journal of biological chemistry 2005;280(15):14844-54.
2005: Virginie Moucadel; Stefan N Constantinescu
Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors.
The Journal of biological chemistry 2005;280(14):13364-73.
2004: Yohan Royer; Catherine Menu; Xuedong Liu; Stefan N Constantinescu
High-throughput gateway bicistronic retroviral vectors for stable expression in mammalian cells: exploring the biologic effects of STAT5 overexpression.
DNA and cell biology 2004;23(6):355-65.
2003: Nadine Seubert; Yohan Royer; Judith Staerk; Katharina F Kubatzky; Virginie Moucadel; Shyam Krishnakumar; Steven O Smith; Stefan N Constantinescu
Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer.
Molecular cell 2003;12(5):1239-50.
2003: Stefan N Constantinescu; Tzvia Keren; William P Russ; Iban Ubarretxena-Belandia; Yaniv Malka; Katharina F Kubatzky; Donald M Engelman; Harvey Lodish; Yoav I Henis
The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins.
The Journal of biological chemistry 2003;278(44):43755-63.
2002: Diane Lejeune; Laure Dumoutier; Stefan N Constantinescu; Wiebe Kruijer; Jan Jacob Schuringa; Jean-Christophe Renauld
Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10.
The Journal of biological chemistry 2002;277(37):33676-82.
2002: Akhilesh Pandey; Nieves Ibarrola; Irina Kratchmarova; Minerva M Fernandez; Stefan N Constantinescu; Osamu Ohara; Sansana Sawasdikosol; Harvey Lodish; Matthias Mann
A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling.
The Journal of biological chemistry 2002;277(21):19131-8.
2001: Lily J. Huang; Stefan N Constantinescu; Harvey Lodish
The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor.
Molecular cell 2001;8(6):1327-38.
2001: Stefan N Constantinescu; Tzvia Keren; Merav Socolovsky; H Nam; Yoav I Henis; Harvey Lodish
Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(8):4379-84.
2001: Stefan N Constantinescu; Lily J. Huang; H Nam; Harvey Lodish
The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif.
Molecular cell 2001;7(2):377-85.
2000: X Liu; Stefan N Constantinescu; Y Sun; Jonathan S Bogan; D Hirsch; Robert A. Weinberg; Harvey Lodish
Generation of mammalian cells stably expressing multiple genes at predetermined levels.
Analytical biochemistry 2000;280(1):20-8.
1999: Stefan N Constantinescu; X Liu; W Beyer; AE Fallon; Srinivasan Shekar; Yoav I Henis; Steven O Smith; Harvey Lodish
Activation of the erythropoietin receptor by the gp55-P viral envelope protein is determined by a single amino acid in its transmembrane domain.
The EMBO journal 1999;18(12):3334-47.
1998: Stefan N Constantinescu; H Wu; X Liu; W Beyer; AE Fallon; Harvey Lodish
The anemic Friend virus gp55 envelope protein induces erythroid differentiation in fetal liver colony-forming units-erythroid.
Blood 1998;91(4):1163-72.
1998: Merav Socolovsky; Stefan N Constantinescu; S Bergelson; A Sirotkin; Harvey Lodish
Cytokines in hematopoiesis: specificity and redundancy in receptor function.
Advances in protein chemistry 1998;52():141-98.
1997: X Liu; Y Sun; Stefan N Constantinescu; E Karam; Robert A. Weinberg; Harvey Lodish
Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(20):10669-74.