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Juan Contreras

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Mert Icyuz; Stacie M J Bryant; Henry K Fortinberry; Kfir Molakandov; Gene P Siegal; Juan L Contreras; Hongju Wu
Adenovirus infection activates akt1 and induces cell proliferation in pancreatic islets1.
Clintoria Richards-Williams; Juan L Contreras; Kathleen H Berecek; Erik M Schwiebert
Extracellular ATP and zinc are co-secreted with insulin and activate multiple P2X purinergic receptor channels expressed by islet beta-cells to potentiate insulin secretion.
Joshua L Argo; Juan L Contreras; Mary M Wesley; John D Christein
Pancreatic resection with islet cell autotransplant for the treatment of severe chronic pancreatitis.

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All Publications

2009: Mert Icyuz; Stacie M J Bryant; Henry K Fortinberry; Kfir Molakandov; Gene P Siegal; Juan L Contreras; Hongju Wu
Adenovirus infection activates akt1 and induces cell proliferation in pancreatic islets1.
Transplantation 2009;87(6):821-4.
2008: Clintoria Richards-Williams; Juan L Contreras; Kathleen H Berecek; Erik M Schwiebert
Extracellular ATP and zinc are co-secreted with insulin and activate multiple P2X purinergic receptor channels expressed by islet beta-cells to potentiate insulin secretion.
Purinergic signalling 2008;4(4):393-405.
2008: Joshua L Argo; Juan L Contreras; Mary M Wesley; John D Christein
Pancreatic resection with islet cell autotransplant for the treatment of severe chronic pancreatitis.
The American surgeon 2008;74(6):530-6; discussion 536-7.
2008: Judith M Thomas; Juan L Contreras; Pei-Xuan Wang; Devin E Eckhoff; Clement K Asiedu; William J Hubbard; Samuel Cartner; Francis T Thomas; Michelle L Robbin; Steven Nadler; William J Cook; Joshua Sharff; David M Neville; Joseph Shiloach
Retraction: Peritransplant tolerance induction with anti-CD3-immunotoxin: a matter of proinflammatory cytokine control.
Transplantation 2008;85(6):920.
2008: Juan L Contreras
Extrahepatic transplant sites for islet xenotransplantation.
Xenotransplantation 2008;15(2):99-101.
2007: Tie Han; Yizhe Tang; Hideyo Ugai; Leslie E Perry; Gene P Siegal; Juan L Contreras; Hongju Wu
Genetic incorporation of the protein transduction domain of Tat into Ad5 fiber enhances gene transfer efficacy.
Virology journal 2007;4():103.
2006: Judith M Thomas; Devin E Eckhoff; Juan L Contreras; Francis T Thomas; David M Neville; Andrew Lobashevsky; William J Hubbard; William J Cook
Retraction: Durable donor-specific T and B cell tolerance in rhesus macaques induced with peritransplantation anti-CD3 immunotoxin and deoxyspergualin: absence of chronic allograft nephropathy.
Transplantation 2006;82(4):577.
2006: Mariam A Stoff-Khalili; Angel A Rivera; Long P Le; Alexander Stoff; Maaike Everts; Juan L Contreras; D Chen; L Teng; Marianne G Rots; Hidde J Haisma; Rodney P Rocconi; Gerd J Bauerschmitz; Daniel T Rein; Masato Yamamoto; Gene P Siegal; Peter Dall; J Michael Mathis; David T Curiel
Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agents.
Cancer gene therapy 2006;13(6):606-18.
2005: Mario Vilatoba; Christopher Eckstein; Guadalupe Bilbao; Cheryl A Smyth; Stacie Jenkins; John A Thompson; Devin E Eckhoff; Juan L Contreras
Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis.
Surgery 2005;138(2):342-51.
2005: Mario Vilatobá; Devin E Eckhoff; Juan L Contreras
[Liver transplantation of living donor adult-to-adult].
Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición 2005;57(2):252-61.
2005: Mario Vilatobá; Devin E Eckhoff; Juan L Contreras
[Recipient selection for liver transplantation].
Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición 2005;57(2):244-51.
2005: Dong Xie; Cheryl A Smyth; Christopher Eckstein; Guadalupe Bilbao; Jimmy Mays; Devin E Eckhoff; Juan L Contreras
Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation.
Biomaterials 2005;26(4):403-12.
2005: Mario Vilatoba; Christopher Eckstein; Guadalupe Bilbao; L Frennete; Devin E Eckhoff; Juan L Contreras
17beta-estradiol differentially activates mitogen-activated protein-kinases and improves survival following reperfusion injury of reduced-size liver in mice.
Transplantation proceedings 2005;37(1):399-403.
2004: Tyler O Kirby; Angel Rivera; Daniel T Rein; Minghui Wang; Ilya V Ulasov; Martina Breidenbach; Manjula Kataram; Juan L Contreras; Carlos Krumdieck; Masato Yamamoto; Marianne G Rots; Hidde J Haisma; Ronald D Alvarez; Parameshwar J Mahasreshti; David T Curiel
A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8697-703.
2004: Juan L Contreras; Christopher Eckstein; Cheryl A Smyth; Guadalupe Bilbao; Mario Vilatoba; Sharman E Ringland; Carlton Young; John A Thompson; José A Fernández; John H Griffin; Devin E Eckhoff
Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death.
Diabetes 2004;53(11):2804-14.
2004: Juan L Contreras; Dong Xie; Jimmy Mays; Cheryl A Smyth; Christopher Eckstein; Firoz G Rahemtulla; Carlton J Young; J Anthony Thompson; Guadalupe Bilbao; David T Curiel; Devin E Eckhoff
A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets.
Surgery 2004;136(3):537-47.
2004: Juan L Contreras; Mario Vilatoba; Christopher Eckstein; Guadalupe Bilbao; J Anthony Thompson; Devin E Eckhoff
Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice.
Surgery 2004;136(2):390-400.
2004: Devin E Eckhoff; Christopher Eckstein; Cheryl A Smyth; Mario Vilatoba; Guadalupe Bilbao; Firoz G Rahemtulla; Carlton J Young; J Anthony Thompson; Irshad H Chaudry; Juan L Contreras
Enhanced isolated pancreatic islet recovery and functionality in rats by 17beta-estradiol treatment of brain death donors.
Surgery 2004;136(2):336-45.
2004: Juan L Contreras; Cheryl A Smyth; David T Curiel; Devin E Eckhoff
Nonhuman primate models in type 1 diabetes research.
ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2004;45(3):334-42.
2003: Juan L Contreras; Christopher Eckstein; Cheryl A Smyth; Marty T Sellers; Mario Vilatoba; Guadalupe Bilbao; Firoz G Rahemtulla; Carlton J Young; John A Thompson; Irshad H Chaudry; Devin E Eckhoff
Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats.
Diabetes 2003;52(12):2935-42.
2003: Juan L Contreras; Cheryl A Smyth; Christopher Eckstein; Guadalupe Bilbao; John A Thompson; Carlton J Young; Devin E Eckhoff
Peripheral mobilization of recipient bone marrow-derived endothelial progenitor cells enhances pancreatic islet revascularization and engraftment after intraportal transplantation.
Surgery 2003;134(2):390-8.
2003: Devin E Eckhoff; Cheryl A Smyth; Christopher Eckstein; Guadalupe Bilbao; Carlton J Young; John A Thompson; Juan L Contreras
Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction.
Surgery 2003;134(2):169-79.
2003: Juan L Contreras; Hongju Wu; Cheryl A Smyth; Christopher Eckstein; Carlton J Young; Toshiro Seki; Guadalupe Bilbao; David T Curiel; Devin E Eckhoff
Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets.
Transplantation 2003;76(1):252-61.
2003: Juan L Contreras; Cheryl A Smyth; Guadalupe Bilbao; Christopher Eckstein; Carlton J Young; John A Thompson; David T Curiel; Devin E Eckhoff
Coupling endoplasmic reticulum stress to cell death program in isolated human pancreatic islets: effects of gene transfer of Bcl-2.
Transplant international : official journal of the European Society for Organ Transplantation 2003;16(7):537-42.
2003: Juan L Contreras; Stacie Jenkins; Devin E Eckhoff; William J Hubbard; Andrew Lobashevsky; Guadalupe Bilbao; Francis T Thomas; David M Neville; Judith M Thomas
Stable alpha- and beta-islet cell function after tolerance induction to pancreatic islet allografts in diabetic primates.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(2):128-38.
2002: Juan L Contreras; Cheryl A Smyth; Guadalupe Bilbao; Carlton J Young; John A Thompson; Devin E Eckhoff
17beta-Estradiol protects isolated human pancreatic islets against proinflammatory cytokine-induced cell death: molecular mechanisms and islet functionality.
Transplantation 2002;74(9):1252-9.
2002: Juan L Contreras; Cheryl A Smyth; Guadalupe Bilbao; Carlton J Young; John A Thompson; Devin E Eckhoff
Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets.
Transplantation 2002;74(8):1063-9.
2002: Guadalupe Bilbao; Juan L Contreras; David T Curiel
Genetically engineered intracellular single-chain antibodies in gene therapy.
Molecular biotechnology 2002;22(2):191-211.
2002: Devin E Eckhoff; Guadalupe Bilbao; Luc Frenette; John A Thompson; Juan L Contreras
17-Beta-estradiol protects the liver against warm ischemia/reperfusion injury and is associated with increased serum nitric oxide and decreased tumor necrosis factor-alpha.
Surgery 2002;132(2):302-9.
2002: Guadalupe Bilbao; Juan L Contreras; Igor Dmitriev; Cheryl A Smyth; Stacie Jenkins; Devin E Eckhoff; Francis Thomas; Judith Thomas; David T Curiel
Genetically modified adenovirus vector containing an RGD peptide in the HI loop of the fiber knob improves gene transfer to nonhuman primate isolated pancreatic islets.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2002;2(3):237-43.
2002: Juan L Contreras; Guadalupe Bilbao; Cheryl A Smyth; Devin E Eckhoff; Xiao Ling Jiang; Stacie Jenkins; Francis T Thomas; David T Curiel; Judith M Thomas
Cytoprotection of pancreatic islets before and early after transplantation using gene therapy.
Kidney international 2002;61(1 Suppl):S79-84.
2001: F Thomas; J Wu; Juan L Contreras; C Smyth; Guadalupe Bilbao; J He; J Thomas
A tripartite anoikis-like mechanism causes early isolated islet apoptosis.
Surgery 2001;130(2):333-8.
2001: Juan L Contreras; Guadalupe Bilbao; Cheryl A Smyth; Devin E Eckhoff; X L Xiang; Stacie Jenkins; Samuel Cartner; David T Curiel; Francis T Thomas; Judith M Thomas
Gene transfer of the Bcl-2 gene confers cytoprotection to isolated adult porcine pancreatic islets exposed to xenoreactive antibodies and complement.
Surgery 2001;130(2):166-74.
2001: Judith M Thomas; Juan L Contreras; C A Smyth; Andrew Lobashevsky; Stacie Jenkins; William J Hubbard; Devin E Eckhoff; Scott Stavrou; David M Neville; Francis T Thomas
Successful reversal of streptozotocin-induced diabetes with stable allogeneic islet function in a preclinical model of type 1 diabetes.
Diabetes 2001;50(6):1227-36.
2001: William J Hubbard; JK Moore; Juan L Contreras; C A Smyth; Z W Chen; Andrew Lobashevsky; K Nagata; David M Neville; Judith M Thomas
Phenotypic and functional analysis of T-cell recovery after anti-CD3 immunotoxin treatment for tolerance induction in rhesus macaques.
Human immunology 2001;62(5):479-87.
2001: Juan L Contreras; Guadalupe Bilbao; Cheryl A Smyth; Xiao Ling Jiang; Devin E Eckhoff; Sheri M Jenkins; Francis T Thomas; David T Curiel; Judith M Thomas
Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene.
Transplantation 2001;71(8):1015-23.
2001: Devin E Eckhoff; Luc Frenette; Marty T Sellers; Brendan M McGuire; Juan L Contreras; John S Bynon; D C McGiffin
Combined cardiac surgery and liver transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2001;7(1):60-1.
2000: Devin E Eckhoff; Carl E Haisch; Juan L Contreras; Francis T Thomas; M Robbins; Luc Frenette; Judith M Thomas
Experience with renal transplantation in the nonhuman primate: a modified ureteroneocystostomy to prevent urologic complications.
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2000;13(5):247-51.
2000: Judith M Thomas; Devin E Eckhoff; Juan L Contreras; Andrew Lobashevsky; William J Hubbard; JK Moore; William J Cook; Francis T Thomas; David M Neville
Durable donor-specific T and B cell tolerance in rhesus macaques induced with peritransplantation anti-CD3 immunotoxin and deoxyspergualin: absence of chronic allograft nephropathy.
Transplantation 2000;69(12):2497-503.
2000: Devin E Eckhoff; Brendan M McGuire; C Young; Marty T Sellers; Juan L Contreras; Luc Frenette; Sharon L Hudson; John S Bynon
Liver transplantation in the era of cost constraints.
Southern medical journal 2000;93(4):392-6.
2000: Juan L Contreras; Devin E Eckhoff; Samuel Cartner; Guadalupe Bilbao; Camillo Ricordi; David M Neville; Francis T Thomas; Judith M Thomas
Long-term functional islet mass and metabolic function after xenoislet transplantation in primates.
Transplantation 2000;69(2):195-201.
2000: Jesús Gómez-Navarro; Juan L Contreras; Waleed O Arafat; Xiao Ling Jiang; David M Krisky; Thomas J Oligino; Pierfrancesco Marconi; B Hubbard; Joseph C Glorioso; David T Curiel; Judith M Thomas
Genetically modified CD34+ cells as cellular vehicles for gene delivery into areas of angiogenesis in a rhesus model.
Gene therapy 2000;7(1):43-52.
2000: Devin E Eckhoff; Todd H Baron; WG Blackard; Desiree E Morgan; R Crowe; Marty T Sellers; Brendan M McGuire; Juan L Contreras; John S Bynon
Role of ERCP in asymptomatic orthotopic liver transplant patients with abnormal liver enzymes.
The American journal of gastroenterology 2000;95(1):141-4.
1999: Judith M Thomas; Juan L Contreras; Xiao Ling Jiang; Devin E Eckhoff; Pei-Xuan Wang; William J Hubbard; Andrew Lobashevsky; Weila Wang; Clement K Asiedu; Scott Stavrou; William J Cook; Michelle L Robbin; Francis T Thomas; David M Neville
Peritransplant tolerance induction in macaques: early events reflecting the unique synergy between immunotoxin and deoxyspergualin.
Transplantation 1999;68(11):1660-73.
1999: Francis T Thomas; Juan L Contreras; Guadalupe Bilbao; Camillo Ricordi; David T Curiel; Judith M Thomas
Anoikis, extracellular matrix, and apoptosis factors in isolated cell transplantation.
Surgery 1999;126(2):299-304.
1999: Guadalupe Bilbao; Juan L Contreras; Devin E Eckhoff; Galina Mikheeva; Victor Krasnykh; Joanne T Douglas; Francis T Thomas; Judith M Thomas; David T Curiel
Reduction of ischemia-reperfusion injury of the liver by in vivo adenovirus-mediated gene transfer of the antiapoptotic Bcl-2 gene.
Annals of surgery 1999;230(2):185-93.
1999: Guadalupe Bilbao; Juan L Contreras; Huang-Ge Zhang; M J Pike; K Overturf; Galina Mikheeva; Victor Krasnykh; David T Curiel
Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic bcl-2 gene.
Journal of virology 1999;73(8):6992-7000.
1999: Juan L Contreras; Devin E Eckhoff; Samuel Cartner; Luc Frenette; Francis T Thomas; Michelle L Robbin; David M Neville; Judith M Thomas
Tolerability and side effects of anti-CD3-immunotoxin in preclinical testing in kidney and pancreatic islet transplant recipients.
Transplantation 1999;68(2):215-9.
1999: Francis T Thomas; Camillo Ricordi; Juan L Contreras; William J Hubbard; Xiao Ling Jiang; Devin E Eckhoff; Samuel Cartner; Guadalupe Bilbao; David M Neville; Judith M Thomas
Reversal of naturally occuring diabetes in primates by unmodified islet xenografts without chronic immunosuppression.
Transplantation 1999;67(6):846-54.
1999: Guadalupe Bilbao; Juan L Contreras; Jesús Gómez-Navarro; Devin E Eckhoff; Galina Mikheeva; Victor Krasnykh; T Hynes; Francis T Thomas; Judith M Thomas; David T Curiel
Genetic modification of liver grafts with an adenoviral vector encoding the Bcl-2 gene improves organ preservation.
Transplantation 1999;67(6):775-83.
1999: Clement K Asiedu; Y Meng; Weila Wang; Z Huang; Juan L Contreras; James F George; Judith M Thomas
Immunoregulatory role of CD8alpha in the veto effect.
Transplantation 1999;67(3):372-80.
1999: Guadalupe Bilbao; Juan L Contreras; Galina Mikheeva; Victor Krasnykh; Devin E Eckhoff; Francis T Thomas; Judith Thomas; David T Curiel
Genetic cytoprotection of human endothelial cells during preservation time with an adenoviral vector encoding the anti-apoptotic human Bcl-2 gene.
Transplantation proceedings 1999;31(1-2):1012-5.
1999: Guadalupe Bilbao; H Zhang; Juan L Contreras; Tong Zhou; M Feng; I Saito; John D Mountz; David T Curiel
Construction of a recombinant adenovirus vector encoding Fas ligand with a CRE/Loxp inducible system.
Transplantation proceedings 1999;31(1-2):792-3.
1998: Devin E Eckhoff; Brendan M McGuire; Carlton J Young; Marty T Sellers; Luc Frenette; Sharon L Hudson; Juan L Contreras; Steven J Bynon
Race: a critical factor in organ donation, patient referral and selection, and orthotopic liver transplantation?
Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 1998;4(6):499-505.
1998: Juan L Contreras; Pei-Xuan Wang; Devin E Eckhoff; Andrew Lobashevsky; Clement K Asiedu; Luc Frenette; Michelle L Robbin; William J Hubbard; Samuel Cartner; S Nadler; William J Cook; J Sharff; J Shiloach; Francis T Thomas; David M Neville; Judith M Thomas
Peritransplant tolerance induction with anti-CD3-immunotoxin: a matter of proinflammatory cytokine control.
Transplantation 1998;65(9):1159-69.
1998: Huang-Ge Zhang; Guadalupe Bilbao; Tong Zhou; Juan L Contreras; Jesús Gómez-Navarro; M Feng; I Saito; John D Mountz; David T Curiel
Application of a Fas ligand encoding a recombinant adenovirus vector for prolongation of transgene expression.
Journal of virology 1998;72(3):2483-90.
1998: Devin E Eckhoff; Brendan M McGuire; Luc Frenette; Juan L Contreras; Sharon L Hudson; John S Bynon
Tacrolimus (FK506) and mycophenolate mofetil combination therapy versus tacrolimus in adult liver transplantation.
Transplantation 1998;65(2):180-7.
1997: Judith M Thomas; David M Neville; Juan L Contreras; Devin E Eckhoff; G Meng; Andrew Lobashevsky; Pei-Xuan Wang; Z Q Huang; Kathryn Verbanac; Carl E Haisch; Francis T Thomas
Preclinical studies of allograft tolerance in rhesus monkeys: a novel anti-CD3-immunotoxin given peritransplant with donor bone marrow induces operational tolerance to kidney allografts.
Transplantation 1997;64(1):124-35.