FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

James Cook

Research Profile

Chemicals & Drugs

Living Beings

Concepts & Ideas

Genes & Molecular Sequences

Molecular Structure

Co-author Network

Publications

TOP 3
Bradford D Fischer; Ojas A Namjoshi; Laura P Teixeira; Michael L van Linn; James M Cook; James K Rowlett
Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation.
Srdjan Joksimovic; Marija M Milinković; Gordana Brajković; James M Cook; Jovana Divljaković; Werner Sieghart; Tamara Timić; Michael L Van Linn; Zdravko Varagic; Wenyuan Yin; Miroslav M Savić
Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α1 GABA(A) receptors.
Daniela Rüedi-Bettschen; Terry Clayton; James M Cook; Sundari Rallapalli; James K Rowlett; Donna M Platt
Modulation of α5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of James Cook (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Bradford D Fischer; Ojas A Namjoshi; Laura P Teixeira; Michael L van Linn; James M Cook; James K Rowlett
Role of gamma-aminobutyric acid type A (GABAA) receptor subtypes in acute benzodiazepine physical dependence-like effects: evidence from squirrel monkeys responding under a schedule of food presentation.
Psychopharmacology 2013;227(2):347-54.
2013: Srdjan Joksimovic; Marija M Milinković; Gordana Brajković; James M Cook; Jovana Divljaković; Werner Sieghart; Tamara Timić; Michael L Van Linn; Zdravko Varagic; Wenyuan Yin; Miroslav M Savić
Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α1 GABA(A) receptors.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2013;23(5):390-9.
2013: Daniela Rüedi-Bettschen; Terry Clayton; James M Cook; Sundari Rallapalli; James K Rowlett; Donna M Platt
Modulation of α5 subunit-containing GABAA receptors alters alcohol drinking by rhesus monkeys.
Alcoholism, clinical and experimental research 2013;37(4):624-34.
2013: Marija Milić; Tamara Radulović; Sundari Rallapalli; Poonam Biawat; James M Cook; Jovana Divljaković; Srdjan Joksimovic; Tamara Timić; Miroslav M Savić
PWZ-029, an inverse agonist selective for α₅ GABAA receptors, improves object recognition, but not water-maze memory in normal and scopolamine-treated rats.
Behavioural brain research 2013;241():206-13.
2013: Leah Makaron; Casey A Moran; Ojas Namjoshi; Sundari Rallapalli; James M Cook; James K Rowlett
Cognition-impairing effects of benzodiazepine-type drugs: role of GABAA receptor subtypes in an executive function task in rhesus monkeys.
Pharmacology, biochemistry, and behavior 2013;104():62-8.
2013: Jovana Divljaković; Marija Milić; Ojas A Namjoshi; Tamara Timić; Veera V Tiruveedhula; James M Cook; Miroslav M Savić
βCCT, an antagonist selective for α(1)GABA(A) receptors, reverses diazepam withdrawal-induced anxiety in rats.
Brain research bulletin 2013;91():1-7.
2013: Ojas A Namjoshi; Hanna Ng; Sundari K Rallapalli; Joachim Ramerstorfer; Bryan L Roth; James K Rowlett; Werner Sieghart; Zdravko Varagic; Zhi-jian Wang; Edward Merle Johnson; Yun-Teng Johnson; Samarpan Majumder; James M Cook
Search for α3β₂/₃γ2 subtype selective ligands that are stable on human liver microsomes.
Bioorganic & medicinal chemistry 2013;21(1):93-101.
2012: Chitra R Edwankar; Rahul V Edwankar; Jeffrey R Deschamps; James M Cook
Nature-inspired stereospecific total synthesis of P-(+)-dispegatrine and four other monomeric sarpagine indole alkaloids.
Angewandte Chemie (International ed. in English) 2012;51(47):11762-5.
2012: Marija Milić; Sundari Rallapalli; James M Cook; Jovana Divljaković; Tamara Timić; Michael L van Linn; Miroslav M Savić
The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats.
Behavioural pharmacology 2012;23(2):191-7.
2012: Rahul V Edwankar; Ojas A Namjoshi; Jeffrey Deschamps; Chitra R Edwankar; James M Cook
Brønsted acid mediated cyclization of enaminones. Rapid and efficient access to the tetracyclic framework of the Strychnos alkaloids.
Journal of natural products 2012;75(2):181-8.
2011: Rahul V Edwankar; Jeffrey Deschamps; Chitra R Edwankar; James M Cook
Regiospecific, enantiospecific total synthesis of C-19 methyl substituted sarpagine alkaloids dihydroperaksine-17-al and dihydroperaksine.
Organic letters 2011;13(19):5216-9.
2011: Ojas A Namjoshi; Angelica Gryboski; German O Fonseca; Michael L Van Linn; Zhi-jian Wang; Jeffrey Deschamps; James M Cook
Development of a two-step route to 3-PBC and βCCt, two agents active against alcohol self-administration in rodent and primate models.
The Journal of organic chemistry 2011;76(11):4721-7.
2010: Bradford D Fischer; Stephanie C Licata; Rahul V Edwankar; Zhi-Jian Wang; Shengming Huang; Xiaohui He; Jianming Yu; Hao Zhou; Edward M Johnson; James M Cook; Roman Furtmüller; Joachim Ramerstorfer; Werner Sieghart; Bryan L Roth; Samarpan Majumder; James K Rowlett
Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure.
Neuropharmacology 2010;59(7-8):612-8.
2010: Wenyuan Yin; Samarpan Majumder; Terry Clayton; Steven Petrou; Michael L VanLinn; Ojas A Namjoshi; C Ma; Brett A Cromer; Bryan L Roth; Donna M Platt; James M Cook
Design, synthesis, and subtype selectivity of 3,6-disubstituted β-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse.
Bioorganic & medicinal chemistry 2010;18(21):7548-64.
2010: Miroslav M Savić; Jelena M Kukić; Renée J Grayer; Marija M Milinković; Petar D Marin; Jovana Divljaković; Michael Van Linn; James M Cook; Silvana D Petrović
Behavioural characterization of four endemic Stachys taxa.
Phytotherapy research : PTR 2010;24(9):1309-16.
2010: M Shahjahan Kabir; Ojas A Namjoshi; Ranjit Verma; Rebecca Polanowski; Sarah M Krueger; David Sherman; Marc A Rott; William R Schwan; Aaron Monte; James M Cook
A new class of potential anti-tuberculosis agents: Synthesis and preliminary evaluation of novel acrylic acid ethyl ester derivatives.
Bioorganic & medicinal chemistry 2010;18(12):4178-86.
2010: M Shahjahan Kabir; Michael Lorenz; Michael L Van Linn; Ojas A Namjoshi; Shamim Ara; James M Cook
A very active cu-catalytic system for the synthesis of aryl, heteroaryl, and vinyl sulfides.
The Journal of organic chemistry 2010;75(11):3626-43.
2010: Michael L Van Linn; James M Cook
Mechanistic studies on the cis to trans epimerization of trisubstituted 1,2,3,4-tetrahydro-beta-carbolines.
The Journal of organic chemistry 2010;75(11):3587-99.
2010: Wenyuan Yin; M Shahjahan Kabir; Zhijian Wang; Sundari K Rallapalli; Jun Ma; James M Cook
Enantiospecific total synthesis of the important biogenetic intermediates along the ajmaline pathway, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epivellosimine and macusine A.
The Journal of organic chemistry 2010;75(10):3339-49.
2010: Miroslav M Savić; Samarpan Majumder; Shengming Huang; Rahul V Edwankar; Roman Furtmüller; Srdjan Joksimovic; Terry Clayton; Joachim Ramerstorfer; Marija M Milinković; Bryan L Roth; Werner Sieghart; James M Cook
Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?
Progress in neuro-psychopharmacology & biological psychiatry 2010;34(2):376-86.
2010: M Shahjahan Kabir; Michael Lorenz; Ojas A Namjoshi; James M Cook
First application of an efficient and versatile ligand for copper-catalyzed cross-coupling reactions of vinyl halides with N-heterocycles and phenols.
Organic letters 2010;12(3):464-7.
2009: Chitra R Edwankar; Rahul V Edwankar; Ojas A Namjoshi; Sundari K Rallapalli; Jie Yang; James M Cook
Recent progress in the total synthesis of indole alkaloids.
Current opinion in drug discovery & development 2009;12(6):752-71.
2009: Miroslav M Savić; Marija M Milinković; Sundari Rallapalli; Terry Clayton; Srdjan Joksimovic; Michael Van Linn; James M Cook
The differential role of alpha1- and alpha5-containing GABA(A) receptors in mediating diazepam effects on spontaneous locomotor activity and water-maze learning and memory in rats.
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2009;12(9):1179-93.
2009: Felix M Rivas; James P Stables; Lauren Murphree; Rahul V Edwankar; Chitra R Edwankar; Shengming Huang; Hiteshkumar D Jain; Hao Zhou; Samarpan Majumder; Subramanian Sankar; Bryan L Roth; Joachim Ramerstorfer; Roman Furtmüller; Werner Sieghart; James M Cook
Antiseizure activity of novel gamma-aminobutyric acid (A) receptor subtype-selective benzodiazepine analogues in mice and rat models.
Journal of medicinal chemistry 2009;52(7):1795-8.
2009: Hephzibah J Kumpaty; Michael L Van Linn; M Shahjahan Kabir; F Holger Försterling; Jeffrey Deschamps; James M Cook
Study of the cis to trans isomerization of 1-phenyl-2,3-disubstituted tetrahydro-beta-carbolines at C(1). Evidence for the carbocation-mediated mechanism.
The Journal of organic chemistry 2009;74(7):2771-9.
2009: Jun Ma; Wenyuan Yin; Hao Zhou; Xuebin Liao; James M Cook
General approach to the total synthesis of 9-methoxy-substituted indole alkaloids: synthesis of mitragynine, as well as 9-methoxygeissoschizol and 9-methoxy-N(b)-methylgeissoschizol.
The Journal of organic chemistry 2009;74(1):264-73.
2008: M Shahjahan Kabir; Kathleen Engelbrecht; Rebecca Polanowski; Sarah M Krueger; Rachel Ignasiak; Marc Rott; William R Schwan; Mary E Stemper; Kurt D Reed; David Sherman; James M Cook; Aaron Monte
New classes of Gram-positive selective antibacterials: inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis.
Bioorganic & medicinal chemistry letters 2008;18(21):5745-9.
2008: Dongmei Han; F Holger Försterling; Xiaoyan Li; Jeffrey Deschamps; Damon Parrish; Hui Cao; Sundari Rallapalli; Terry Clayton; Yun Teng; Samarpan Majumder; Subramaniam Sankar; Bryan L Roth; Werner Sieghart; Roman Furtmuller; James K Rowlett; Michael Weed; James M Cook
A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis.
Bioorganic & medicinal chemistry 2008;16(19):8853-62.
2008: Jie Yang; Xiangyu Z Wearing; Philip W Le Quesne; Jeffrey Deschamps; James M Cook
Enantiospecific synthesis of (+)-alstonisine via a stereospecific osmylation process.
Journal of natural products 2008;71(8):1431-40.
2008: Miroslav M Savić; Terry Clayton; Roman Furtmüller; Ivana Gavrilović; Janko Samardzić; Snezana Savić; Sigismund Huck; Werner Sieghart; James M Cook
PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats.
Brain research 2008;1208():150-9.
2008: Hiteshkumar D Jain; Chunchun Zhang; Shuo Zhou; Hao Zhou; Jun Ma; Xiaoxiang Liu; Xuebin Liao; Amy M Deveau; Christine M Dieckhaus; Michael A Johnson; Kirsten S Smith; Timothy L MacDonald; Hideaki Kakeya; Hiroyuki Osada; James M Cook
Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein.
Bioorganic & medicinal chemistry 2008;16(8):4626-51.
2008: Miroslav M Savić; Shengming Huang; Roman Furtmüller; Terry Clayton; Sigismund Huck; Dragan I Obradović; Nenad D Ugresić; Werner Sieghart; Dubravko R Bokonjić; James M Cook
Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2008;33(2):332-9.
2007: Jun Ma; Wenyuan Yin; Hao Zhou; James M Cook
Total synthesis of the opioid agonistic indole alkaloid mitragynine and the first total syntheses of 9-methoxygeissoschizol and 9-methoxy-Nb-methylgeissoschizol.
Organic letters 2007;9(18):3491-4.
2007: Xuebin Liao; Shengming Huang; Hao Zhou; Damon Parrish; James M Cook
Cascade approach toward the core structure of neosarpagine.
Organic letters 2007;9(8):1469-71.
2007: Wenyuan Yin; Jun Ma; Felix M Rivas; James M Cook
First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A.
Organic letters 2007;9(2):295-8.
2007: T Clayton; J L Chen; M Ernst; L Richter; B A Cromer; Craig J Morton; H Ng; C C Kaczorowski; F J Helmstetter; Roman Furtmüller; G Ecker; M W Parker; Werner Sieghart; James M Cook
An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models.
Current medicinal chemistry 2007;14(26):2755-75.
2007: Dongmei Han; F Holger Försterling; Jeffrey Deschamps; Damon Parrish; Xiaoxiang Liu; Wenyuan Yin; Shengming Huang; James M Cook
Conformational analysis of the cis- and trans-adducts of the Pictet - Spengler reaction. Evidence for the structural basis for the C(1) - N(2) scission process in the cis- to trans-isomerization.
Journal of natural products 2007;70(1):75-82.
2007: Harry L June; Katrina L Foster; William J A Eiler; Josuha Goergen; Jason B Cook; Nathan Johnson; Boikai Mensah-Zoe; Jothan O Simmons; Harry L June; Wenyuan Yin; James M Cook; Gregg E Homanics
Dopamine and benzodiazepine-dependent mechanisms regulate the EtOH-enhanced locomotor stimulation in the GABAA alpha1 subunit null mutant mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007;32(1):137-52.
2006: Xuebin Liao; Hao Zhou; Jianming Yu; James M Cook
An improved total synthesis of (+)-macroline and alstonerine as well as the formal total synthesis of (-)-talcarpine and (-)-anhydromacrosalhine-methine.
The Journal of organic chemistry 2006;71(23):8884-90.
2006: Miroslav M Savić; Dragan I Obradović; Nenad D Ugresić; James M Cook; Wenyuan Yin; Michael Van Linn; Dubravko R Bokonjić
Benzodiazepine site inverse agonists and locomotor activity in rats: bimodal and biphasic influence.
Pharmacology, biochemistry, and behavior 2006;84(1):35-42.
2006: P V V Srirama Sarma; James M Cook
Enantiospecific synthesis of (+)-N(a)-methylpericyclivine and (-)-N(a)-methylakuammidine as well as the ring-A oxygenated natural products, (+)-10-methoxy N(a)-methylpericyclivine and 10-hydroxy N(a)-methylpericyclivine.
Organic letters 2006;8(6):1017-20.
2006: Hao Zhou; Xuebin Liao; Wenyuan Yin; Jun Ma; James M Cook
General approach for the synthesis of 12-methoxy-substituted sarpagine indole alkaloids including (-)-12-methoxy-N(b)-methylvoachalotine, (+)-12-methoxy-N(a)-methylvellosimine, (+)-12-methoxyaffinisine, and (-)-fuchsiaefoline.
The Journal of organic chemistry 2006;71(1):251-9.
2005: Xuebin Liao; Hao Zhou; Xiangyu Z Wearing; Jun Ma; James M Cook
The first regiospecific, enantiospecific total synthesis of 6-oxoalstophylline and an improved total synthesis of alstonerine and alstophylline as well as the bisindole alkaloid macralstonine.
Organic letters 2005;7(16):3501-4.
2005: Jason B Cook; Katrina L Foster; William J A Eiler; Peter F McKay; James Woods; Scott C Harvey; Marin Garcia; Collette Grey; Shannan McCane; Dynesha Mason; Rancia Cummings; Xiaoyan Li; James M Cook; Harry L June
Selective GABAA alpha5 benzodiazepine inverse agonist antagonizes the neurobehavioral actions of alcohol.
Alcoholism, clinical and experimental research 2005;29(8):1390-401.
2005: Miroslav M Savić; Dragan I Obradović; Nenad D Ugresić; James M Cook; P V V S Sarma; Dubravko R Bokonjić
Bidirectional effects of benzodiazepine binding site ligands on active avoidance acquisition and retention: differential antagonism by flumazenil and beta-CCt.
Psychopharmacology 2005;180(3):455-65.
2005: P V V Srirama Sarma; Dongmei Han; Jeffrey Deschamps; James M Cook
Confirmation of the structure of (3S)-3-hydroxyquinine: synthesis and X-ray crystal structure of its 9-aceto analogue.
Journal of natural products 2005;68(6):942-4.
2005: Jianming Yu; Xiangyu Z Wearing; James M Cook
A general strategy for the synthesis of vincamajine-related indole alkaloids: stereocontrolled total synthesis of (+)-dehydrovoachalotine, (-)-vincamajinine, and (-)-11-methoxy-17-epivincamajine as well as the related quebrachidine diol, vincamajine diol, and vincarinol.
The Journal of organic chemistry 2005;70(10):3963-79.
2005: Miroslav M Savić; Dragan I Obradović; Nenad D Ugresić; James M Cook; Wenyuan Yin; Dubravko R Bokonjić
Bidirectional effects of benzodiazepine binding site ligands in the passive avoidance task: differential antagonism by flumazenil and beta-CCt.
Behavioural brain research 2005;158(2):293-300.
2005: Hui Cao; Scott G Van Ornum; Jeffrey Deschamps; Judith L Flippen-Anderson; Frank Laib; James M Cook
Synthesis of dicyclopenta[a,e]pentalenes via a molybdenum carbonyl mediated tandem allenic Pauson-Khand reaction and the X-ray crystal structure of a planar dicyclopenta[a,e]pentalene.
Journal of the American Chemical Society 2005;127(3):933-43.
2004: Miroslav M Savić; Dragan I Obradović; Nenad D Ugresić; James M Cook; Wenyuan Yin; Dubravko R Bokonjić
Bidirectional effects of benzodiazepine binding site ligands in the elevated plus-maze: differential antagonism by flumazenil and beta-CCt.
Pharmacology, biochemistry, and behavior 2004;79(2):279-90.
2004: Peter F McKay; Katrina L Foster; Dynesha Mason; Rancia Cummings; Marin Garcia; La Shone Williams; Collette Grey; Shannan McCane; Xiaohui He; James M Cook; Harry L June
A high affinity ligand for GABAA-receptor containing alpha5 subunit antagonizes ethanol's neurobehavioral effects in Long-Evans rats.
Psychopharmacology 2004;172(4):455-62.
2004: Dongmei Han; F Holger Försterling; Xiaoyan Li; Jeffrey Deschamps; Hui Cao; James M Cook
Determination of the stable conformation of GABA(A)-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis.
Bioorganic & medicinal chemistry letters 2004;14(6):1465-9.
2004: Jianming Yu; Xiangyu Z Wearing; James M Cook
Stereocontrolled total synthesis of (-)-vincamajinine and (-)-11-methoxy-17-epivincamajine.
Journal of the American Chemical Society 2004;126(5):1358-9.
2004: Katrina L Foster; Peter F McKay; Regat Seyoum; Dana Milbourne; Wenyuan Yin; P V V S Sarma; James M Cook; Harry L June
GABA(A) and opioid receptors of the central nucleus of the amygdala selectively regulate ethanol-maintained behaviors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(2):269-84.
2004: Hao Zhou; Xuebin Liao; James M Cook
Regiospecific, enantiospecific total synthesis of the 12-alkoxy-substituted indole alkaloids, (+)-12-methoxy-Na-methylvellosimine, (+)-12-methoxyaffinisine, and (-)-fuchsiaefoline.
Organic letters 2004;6(2):249-52.
2003: Xiaoyan Li; Hui Cao; Chunchun Zhang; Roman Furtmueller; Karoline Fuchs; Sigismund Huck; Werner Sieghart; Jeffrey Deschamps; James M Cook
Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist.
Journal of medicinal chemistry 2003;46(26):5567-70.
2003: Harry L June; Katrina L Foster; Peter F McKay; Regat Seyoum; James E Woods; Scott C Harvey; William J A Eiler; Collette Grey; Michelle R Carroll; Shannan McCane; Cecily M Jones; Wenyuan Yin; Dynesha Mason; Rancia Cummings; Marin Garcia; Chunrong Ma; P V V S Sarma; James M Cook; Phil Skolnick
The reinforcing properties of alcohol are mediated by GABA(A1) receptors in the ventral pallidum.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(12):2124-37.
2003: Jianming Yu; Tao Wang; Xiaoxiang Liu; Jeffrey Deschamps; Judith L Flippen-Anderson; Xuebin Liao; James M Cook
General approach for the synthesis of sarpagine indole alkaloids. Enantiospecific total synthesis of (+)-vellosimine, (+)-normacusine B, (-)-alkaloid Q3, (-)-panarine, (+)-Na-methylvellosimine, and (+)-Na-methyl-16-epipericyclivine.
The Journal of organic chemistry 2003;68(20):7565-81.
2003: Shuo Zhao; Xuebin Liao; Tao Wang; Judith L Flippen-Anderson; James M Cook
The enantiospecific, stereospecific total synthesis of the ring-A oxygenated sarpagine indole alkaloids (+)-majvinine, (+)-10-methoxyaffinisine, and (+)-N(a)-methylsarpagine, as well as the total synthesis of the alstonia bisindole alkaloid macralstonidine.
The Journal of organic chemistry 2003;68(16):6279-95.
2003: Jianming Yu; Tao Wang; Xiangyu Z Wearing; Jun Ma; James M Cook
Enantiospecific total synthesis of (-)-(E)16-epiaffinisine, (+)-(E)16-epinormacusine B, and (+)-dehydro-16-epiaffinisine as well as the stereocontrolled total synthesis of alkaloid G.
The Journal of organic chemistry 2003;68(15):5852-9.
2003: Hui Cao; Judith L Flippen-Anderson; James M Cook
The synthesis of a dicyclopenta[a,e]pentalene via a molybdenum hexacarbonyl-mediated tandem allenic Pauson-Khand reaction.
Journal of the American Chemical Society 2003;125(11):3230-1.
2002: Jianming Yu; Xuebin Liao; James M Cook
Stereospecific, enantiospecific total synthesis of the sarpagine indole alkaloids (E)16-epiaffinisine, (E)16-epinormacusine B, and dehydro-16-epiaffinisine.
Organic letters 2002;4(26):4681-4.
2002: Xiangyu Z Wearing; James M Cook
Enantiospecific, stereospecific total synthesis of the oxindole alkaloid alstonisine.
Organic letters 2002;4(24):4237-40.
2002: Xiaoxiang Liu; Jeffrey R Deschamp; James M Cook
Regiospecific, enantiospecific total synthesis of the alkoxy-substituted indole bases, 16-epi-N(a)-methylgardneral, 11-methoxyaffinisine, and 11-methoxymacroline as well as the indole alkaloids alstophylline and macralstonine.
Organic letters 2002;4(20):3339-42.
2002: Scott C Harvey; Katrina L Foster; Peter F McKay; Michelle R Carroll; Regat Seyoum; James E Woods; Collette Grey; Cecily M Jones; Shannan McCane; Rancia Cummings; Dynesha Mason; Chunrong Ma; James M Cook; Harry L June
The GABA(A) receptor alpha1 subtype in the ventral pallidum regulates alcohol-seeking behaviors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(9):3765-75.
2002: Shuo Zhao; Kirsten S Smith; Amy Morin Deveau; Christine M Dieckhaus; Michael A Johnson; Timothy L MacDonald; James M Cook
Biological activity of the tryprostatins and their diastereomers on human carcinoma cell lines.
Journal of medicinal chemistry 2002;45(8):1559-62.
2002: Shuo Zhao; Xuebin Liao; James M Cook
Enantiospecific, stereospecific total synthesis of (+)-majvinine, (+)-10-methoxyaffinisine, and (+)-N(a)-methylsarpagine as well as the total synthesis of the Alstonia bisindole macralstonidine.
Organic letters 2002;4(5):687-90.
2001: Xiaoxiang Liu; James M Cook
General approach for the synthesis of sarpagine/macroline indole alkaloids. Enantiospecific total synthesis of the indole alkaloid trinervine.
Organic letters 2001;3(25):4023-6.
2001: C Ma; Xiaoxiang Liu; X Li; Judith L Flippen-Anderson; S Yu; James M Cook
Efficient asymmetric synthesis of biologically important tryptophan analogues via a palladium-mediated heteroannulation reaction.
The Journal of organic chemistry 2001;66(13):4525-42.
2001: Harry L June; Scott C Harvey; Katrina L Foster; Peter F McKay; Rancia Cummings; Marin Garcia; Dynesha Mason; Collette Grey; Shannan McCane; La Shone Williams; T B Johnson; X He; S Rock; James M Cook
GABA(A) receptors containing (alpha)5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors: an extended ethanol reward circuitry.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(6):2166-77.
2001: T Zheng; Judith L Flippen-Anderson; P Yu; Tao Wang; R Mirghani; James M Cook
Stereocontrolled conversion of quinine into 10(R),11-dihydroxydihydroquinine via the sharpless osmylation process.
The Journal of organic chemistry 2001;66(4):1509-11.
2001: Tao Wang; Q Xu; P Yu; Xiaoxiang Liu; James M Cook
Stereocontrolled total synthesis of alkaloid G via the oxy-anion Cope rearrangement and improved total synthesis of (+)-ajmaline.
Organic letters 2001;3(3):345-8.
2000: Tao Wang; James M Cook
General approach for the synthesis of sarpagine/ajmaline indole alkaloids. Stereospecific total synthesis of the sarpagine alkaloid (+)-vellosimine.
Organic letters 2000;2(14):2057-9.
2000: P Yu; Tao Wang; J Li; James M Cook
Enantiospecific total synthesis of the sarpagine related indole alkaloids talpinine and talcarpine as well as the improved total synthesis of alstonerine and anhydromacrosalhine-methine via the asymmetric Pictet-Spengler reaction.
The Journal of organic chemistry 2000;65(10):3173-91.
2000: Q Huang; X He; C Ma; R Liu; S Yu; C A Dayer; Galen R Wenger; RM McKernan; James M Cook
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach.
Journal of medicinal chemistry 2000;43(1):71-95.
2000: X He; Q Huang; C Ma; S Yu; RM McKernan; James M Cook
Pharmacophore/receptor models for GABA(A)/BzR alpha2beta3gamma2, alpha3beta3gamma2 and alpha4beta3gamma2 recombinant subtypes. Included volume analysis and comparison to alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2 subtypes.
Drug design and discovery 2000;17(2):131-71.
1999: X He; Q Huang; S Yu; C Ma; RM McKernan; James M Cook
Studies of molecular pharmacophore/receptor models for GABAA/BzR subtypes: binding affinities of symmetrically substituted pyrazolo[4,3-c]quinolin-3-ones at recombinant alpha x beta 3 gamma 2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis.
Drug design and discovery 1999;16(1):77-91.
1999: Q Huang; E D Cox; T Gan; C Ma; Dennis W Bennett; RM McKernan; James M Cook
Studies of molecular pharmacophore/receptor models for GABAA/benzodiazepine receptor subtypes: binding affinities of substituted beta-carbolines at recombinant alpha x beta 3 gamma 2 subtypes and quantitative structure-activity relationship studies via a comparative molecular field analysis.
Drug design and discovery 1999;16(1):55-76.
1998: Q Huang; R Liu; P Zhang; X He; RM McKernan; T Gan; Dennis W Bennett; James M Cook
Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via comparative molecular field analysis.
Journal of medicinal chemistry 1998;41(21):4130-42.
1998: E D Cox; H Diaz-Arauzo; Q Huang; M S Reddy; C Ma; Bradford Harris; RM McKernan; P Skolnick; James M Cook
Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors.
Journal of medicinal chemistry 1998;41(14):2537-52.
1998: Harry L June; CR Cason; G Cheatham; R Lui; T Gan; James M Cook
GABAA-benzodiazepine receptors in the striatum are involved in the sedation produced by a moderate, but not an intoxicating ethanol dose in outbred Wistar rats.
Brain research 1998;794(1):103-18.
1996: R Liu; R J Hu; P Zhang; Phil Skolnick; James M Cook
Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors.
Journal of medicinal chemistry 1996;39(9):1928-34.
1995: P Zhang; W Zhang; R Liu; Bradford Harris; Phil Skolnick; James M Cook
Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors.
Journal of medicinal chemistry 1995;38(10):1679-88.
1995: W Zhang; Koehler F Konrad; P Zhang; James M Cook
Development of a comprehensive pharmacophore model for the benzodiazepine receptor.
Drug design and discovery 1995;12(3):193-248.
1994: W Zhang; Koehler F Konrad; Bradford Harris; Phil Skolnick; James M Cook
Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors.
Journal of medicinal chemistry 1994;37(6):745-57.
1993: G Wong; Koehler F Konrad; Phil Skolnick; Z Q Gu; S Ananthan; P Schönholzer; W Hunkeler; W Zhang; James M Cook
Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors.
Journal of medicinal chemistry 1993;36(13):1820-30.
1992: M S Allen; A J LaLoggia; L J Dorn; M J Martin; G Costantino; T J Hagen; Koehler F Konrad; Phil Skolnick; James M Cook
Predictive binding of beta-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach.
Journal of medicinal chemistry 1992;35(22):4001-10.
1992: K Takada; J E Barrett; M S Allen; James M Cook; Jonathan L Katz
Punishment of schedule-controlled behavior with beta-carboline injections: antagonism and comparisons with other compounds.
The Journal of pharmacology and experimental therapeutics 1992;261(1):138-45.
1992: M S Allen; Phil Skolnick; James M Cook
Synthesis of novel 2-phenyl-2H-pyrazolo[4,3-c]isoquinolin-3-ols: topological comparisons with analogues of 2-phenyl-2,5-dihydropyrazolo[4,3-c]quinolin-3(3H)-ones at benzodiazepine receptors.
Journal of medicinal chemistry 1992;35(2):368-74.
1991: H Diaz-Arauzo; G E Evoniuk; Phil Skolnick; James M Cook
The agonist pharmacophore of the benzodiazepine receptor. Synthesis of a selective anticonvulsant/anxiolytic.
Journal of medicinal chemistry 1991;34(5):1754-6.
1991: H Diaz-Arauzo; Koehler F Konrad; T J Hagen; James M Cook
Synthetic and computer assisted analysis of the pharmacophore for agonists at benzodiazepine receptors.
Life sciences 1991;49(3):207-16.
1990: M L Trudell; S L Lifer; Y C Tan; M J Martin; L Deng; Phil Skolnick; James M Cook
Synthesis of substituted 7,12-dihydropyrido[3,2-b:5,4-b']diindoles: rigid planar benzodiazepine receptor ligands with inverse agonist/antagonist properties.
Journal of medicinal chemistry 1990;33(9):2412-20.
1990: S P Hollinshead; M L Trudell; Phil Skolnick; James M Cook
Structural requirements for agonist actions at the benzodiazepine receptor: studies with analogues of 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester.
Journal of medicinal chemistry 1990;33(3):1062-9.
1990: H Díaz-Araúzo; James M Cook; D J Christie
Synthesis of 10,11-dihydroxydihydroquinidine N-oxide, a new metabolite of quinidine. Preparation and 1H-nmr spectroscopy of the metabolites of quinine and quinidine and conformational analysis via 2D COSY nmr spectroscopy.
Journal of natural products 1990;53(1):112-24.
1990: James M Cook; H Diaz-Arauzo; M S Allen
Inverse agonists, probes to study the structure, topology and function of the benzodiazepine receptor.
NIDA research monograph 1990;105():133-9.
1989: J V Martin; James M Cook; T J Hagen; W B Mendelson
Inhibition of sleep and benzodiazepine receptor binding by a beta-carboline derivative.
Pharmacology, biochemistry, and behavior 1989;34(1):37-42.
1989: K Takada; T Suzuki; T Hagen; James M Cook; Jonathan L Katz
Behavioral effects of benzodiazepine antagonists in chlordiazepoxide tolerant and non-tolerant rats.
Life sciences 1989;44(4):289-99.
1988: M S Allen; T J Hagen; M L Trudell; P W Codding; Phil Skolnick; James M Cook
Synthesis of novel 3-substituted beta-carbolines as benzodiazepine receptor ligands: probing the benzodiazepine receptor pharmacophore.
Journal of medicinal chemistry 1988;31(9):1854-61.
1988: D J Christie; H Diaz-Arauzo; James M Cook
Antibody-mediated platelet destruction by quinine, quinidine, and their metabolites.
The Journal of laboratory and clinical medicine 1988;112(1):92-8.
1988: K Takada; T J Hagen; James M Cook; Steven R Goldberg; Jonathan L Katz
Discriminative stimulus effects of intravenous nicotine in squirrel monkeys.
Pharmacology, biochemistry, and behavior 1988;30(1):243-7.
1988: Ramon Trullas; H Ginter; B Jackson; Phil Skolnick; M S Allen; T J Hagen; James M Cook
3-Ethoxy-beta-carboline: a high affinity benzodiazepine receptor ligand with partial inverse agonist properties.
Life sciences 1988;43(15):1189-97.
1987: T J Hagen; Phil Skolnick; James M Cook
Synthesis of 6-substituted beta-carbolines that behave as benzodiazepine receptor antagonists or inverse agonists.
Journal of medicinal chemistry 1987;30(4):750-3.
1987: M L Trudell; Anthony Basile; H E Shannon; Phil Skolnick; James M Cook
Synthesis of 7,12-dihydropyrido[3,4-b:5,4-b']diindoles. A novel class of rigid, planar benzodiazepine receptor ligands.
Journal of medicinal chemistry 1987;30(3):456-8.
1986: W E Hoffman; Ronald F Albrecht; D J Miletich; T J Hagen; James M Cook
Cerebrovascular and cerebral metabolic effects of physostigmine, midazolam, and a benzodiazepine antagonist.
Anesthesia and analgesia 1986;65(6):639-44.
1984: D J Christie; R W Weber; P C Mullen; James M Cook; R H Aster
Structural features of the quinidine and quinine molecules necessary for binding of drug-induced antibodies to human platelets.
The Journal of laboratory and clinical medicine 1984;104(5):730-40.