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Dan Cook

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Chemicals & Drugs

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Publications

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Nicholas A Boyle; Vivek K Rajwanshi; Marija Prhavc; Guangyi Wang; Patrick Fagan; Fu Chen; Gregory J Ewing; Jennifer L Brooks; Tiffany Hurd; Janet M Leeds; Thomas W Bruice; P Dan Cook
Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase.
Thazha P Prakash; Marija Prhavc; Anne B Eldrup; P Dan Cook; Steven S Carroll; David B Olsen; Mark Stahlhut; Joanne E Tomassini; Malcolm MacCoss; Sheila M Galloway; Cathy Hilliard; Balkrishen Bhat
Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
Nicholas A Boyle; Patrick Fagan; Jennifer L Brooks; Marija Prhavc; John Lambert; P Dan Cook
2',3'-dideoxynucleoside 5'-beta, gamma-(difluoromethylene) triphosphates with alpha-P-thio or alpha-P-seleno modifications: synthesis and their inhibition of HIV-1 reverse transcriptase.

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All Publications

2005: Nicholas A Boyle; Vivek K Rajwanshi; Marija Prhavc; Guangyi Wang; Patrick Fagan; Fu Chen; Gregory J Ewing; Jennifer L Brooks; Tiffany Hurd; Janet M Leeds; Thomas W Bruice; P Dan Cook
Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase.
Journal of medicinal chemistry 2005;48(7):2695-700.
2005: Thazha P Prakash; Marija Prhavc; Anne B Eldrup; P Dan Cook; Steven S Carroll; David B Olsen; Mark Stahlhut; Joanne E Tomassini; Malcolm MacCoss; Sheila M Galloway; Cathy Hilliard; Balkrishen Bhat
Synthesis and evaluation of S-acyl-2-thioethyl esters of modified nucleoside 5'-monophosphates as inhibitors of hepatitis C virus RNA replication.
Journal of medicinal chemistry 2005;48(4):1199-210.
2005: Nicholas A Boyle; Patrick Fagan; Jennifer L Brooks; Marija Prhavc; John Lambert; P Dan Cook
2',3'-dideoxynucleoside 5'-beta, gamma-(difluoromethylene) triphosphates with alpha-P-thio or alpha-P-seleno modifications: synthesis and their inhibition of HIV-1 reverse transcriptase.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1651-64.
2005: Vivek K Rajwanshi; Marija Prhavc; Patrick Fagan; Jennifer L Brooks; Tiffany Hurd; P Dan Cook; Guangyi Wang
Synthesis of 5'-triphosphate mimics (P3Ms) of 3'-azido-3',5'-dideoxythymidine and 3',5'-dideoxy-5'-difluoromethylenethymidine as HIV-1 reverse transcriptase inhibitors.
Nucleosides, nucleotides & nucleic acids 2005;24(3):179-89.
2004: Guangyi Wang; Nicholas A Boyle; Fu Chen; Vasanthakumar Rajappan; Patrick Fagan; Jennifer L Brooks; Tiffany Hurd; Janet M Leeds; Vivek K Rajwanshi; Yi Jin; Marija Prhavc; Thomas W Bruice; P Dan Cook
Synthesis of AZT 5'-triphosphate mimics and their inhibitory effects on HIV-1 reverse transcriptase.
Journal of medicinal chemistry 2004;47(27):6902-13.
2004: Anne B Eldrup; Marija Prhavc; Jennifer Brooks; Balkrishen Bhat; Thazha P Prakash; Quanlai Song; Sanjib Bera; Neelima Bhat; Prasad Dande; P Dan Cook; C Frank Bennett; Steven S Carroll; Richard G Ball; Michele Bosserman; Christine Burlein; Lawrence F Colwell; John F Fay; Osvaldo A Flores; Krista Getty; Robert L LaFemina; Joseph F Leone; Malcolm MacCoss; Daniel R McMasters; Joanne E Tomassini; Derek Von Langen; Bohdan Wolanski; David B Olsen
Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.
Journal of medicinal chemistry 2004;47(21):5284-97.
2004: Anne B Eldrup; Charles R Allerson; C Frank Bennett; Sanjib Bera; Balkrishen Bhat; Neelima Bhat; Michele Bosserman; Jennifer Brooks; Christine Burlein; Steven S Carroll; P Dan Cook; Krista Getty; Malcolm MacCoss; Daniel R McMasters; David B Olsen; Thazha P Prakash; Marija Prhavc; Quanlai Song; Joanne E Tomassini; Jie Xia
Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.
Journal of medicinal chemistry 2004;47(9):2283-95.
2004: Guangyi Wang; Kandasamy Sakthivel; Vasanthakumar Rajappan; Thomas W Bruice; Kathleen Tucker; Patrick Fagan; Jennifer L Brooks; Tiffany Hurd; Janet M Leeds; P Dan Cook
Synthesis of azole nucleoside 5'-monophosphate mimics (P1Ms) and their inhibitory properties of IMP dehydrogenases.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):317-37.
2003: Marija Prhavc; Thazha P Prakash; George Minasov; P Dan Cook; Martin Egli; Muthiah Manoharan
2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects.
Organic letters 2003;5(12):2017-20.
2001: Marija Prhavc; Balkrishen Bhat; George Just; P Dan Cook; Muthiah Manoharan
Chimeric RNA with modified backbones: alternating methylene(methylimino) linked phosphodiester backbone oligonucleotides with 2'-OH and 2'-OMe groups.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):995-7.
1999: Marianna Teplova; S T Wallace; Valentina Tereshko; George Minasov; AM Symons; P Dan Cook; Muthiah Manoharan; Martin Egli
Structural origins of the exonuclease resistance of a zwitterionic RNA.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(25):14240-5.
1999: Muthiah Manoharan; L K Andrade; P Dan Cook
Site-specific cross-linking of nucleic acids using the abasic site.
Organic letters 1999;1(2):311-4.
1999: L M Cowsert; C T Ohashi; Balkrishen Bhat; D Peoc'h; AM Symons; P Dan Cook; Muthiah Manoharan
MMI linkage modification increases potency and stability of H-ras antisense oligonucleotides.
Nucleosides & nucleotides 1999;18(6-7):1383-4.
1999: Marianna Teplova; George Minasov; Valentina Tereshko; Gopal B Inamati; P Dan Cook; Muthiah Manoharan; Martin Egli
Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nature structural biology 1999;6(6):535-9.
1999: Allister S Fraser; Andrew M Kawasaki; P Dan Cook
Purine based combinatorial chemistry: solution phase simultaneous addition of functionalities. Iterative deconvolution by orthogonal protection to a single compound with potent antibacterial activity.
Nucleosides & nucleotides 1999;18(4-5):1087-9.
1999: Neil A Whittemore; A N Mullenix; Gopal B Inamati; Muthiah Manoharan; P Dan Cook; Albert A Tuinman; David C Baker; J Q Chambers
Synthesis and electrochemistry of anthraquinone-oligodeoxynucleotide conjugates.
Bioconjugate chemistry 1999;10(2):261-70.
1998: H An; B D Haly; P Dan Cook
New piperazinyl polyazacyclophane scaffolds, libraries and biological activities.
Bioorganic & medicinal chemistry letters 1998;8(17):2345-50.
1998: H An; B D Haly; P Dan Cook
Discovery of novel pyridinopolyamines with potent antimicrobial activity: deconvolution of mixtures synthesized by solution-phase combinatorial chemistry.
Journal of medicinal chemistry 1998;41(5):706-16.
1997: Martin K Bijsterbosch; Muthiah Manoharan; ET Rump; RL De Vrueh; Richard Van Veghel; K L Tivel; Erik A L Biessen; C Frank Bennett; P Dan Cook; Theo Van berkel
In vivo fate of phosphorothioate antisense oligodeoxynucleotides: predominant uptake by scavenger receptors on endothelial liver cells.
Nucleic acids research 1997;25(16):3290-6.