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David Allen
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Research Profile (preview)
Physiology
Living Beings
Chemicals & Drugs
Anatomy
Disorders
Devices
Procedures
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Network (preview)
26
Lockman, Paul
11
Yokel, Robert
10
Geldenhuys, Werner
9
Mumper, Russell
9
Van Der Schyf, Cornelis
7
Cárdenas, Ana María
7
Caviedes, Pablo
7
Caviedes, Raúl
6
Abbruscato, Thomas
6
Koziara, Joanna
5
Rapoport, Stanley
5
Roder, Karen
5
Arriagada, Christian
5
Dwoskin, Linda
4
Smith, Quentin
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Publications
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All Publications
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2008: Zhang Zhenfa; Lockman Paul R; Mittapalli Rajendar K; Allen David D; Dwoskin Linda P; Crooks Peter A
bis-Pyridinium cyclophanes: novel ligands with high affinity for the blood-brain barrier choline transporter.
Bioorganic & medicinal chemistry letters 2008;18(20):5622-5.
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2008: Lockman Paul R; Manda Vamshi K; Geldenhuys Werner J; Mittapalli Rajendar K; Thomas Fancy; Albayati Zaineb Fadhel; Crooks Peter A; Dwoskin Linda P; Allen David D
Carrier-mediated transport of the quaternary ammonium neuronal nicotinic receptor antagonist n,n'-dodecylbispicolinium dibromide at the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 2008;324(1):244-50.
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2007: Gaasch Julie A; Geldenhuys Werner J; Lockman Paul R; Allen David D; Van der Schyf Cornelis J
Voltage-gated calcium channels provide an alternate route for iron uptake in neuronal cell cultures.
Neurochemical research 2007;32(10):1686-93.
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2007: Gaasch Julie A; Lockman Paul R; Geldenhuys Werner J; Allen David D; Van der Schyf Cornelis J
Brain iron toxicity: differential responses of astrocytes, neurons, and endothelial cells.
Neurochemical research 2007;32(7):1196-208.
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2007: Schugar Harvey; Green David E; Bowen Meryn L; Scott Lauren E; Storr Tim; Böhmerle Karin; Thomas Fancy; Allen David D; Lockman Paul R; Merkel Michael; Thompson Katherine H; Orvig Chris
Combating Alzheimer's disease with multifunctional molecules designed for metal passivation.
Angewandte Chemie (International ed. in English) 2007;46(10):1716-8.
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2006: Opazo Patricia; Saud Katherine; de Saint Pierre Michelle; Cárdenas Ana María; Allen David D; Segura-Aguilar Juan; Caviedes Raúl; Caviedes Pablo
Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome.
Journal of neuroscience research 2006;84(6):1303-10.
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2006: McCall Kenneth L; Allen David D; Fike David S
Predictors of academic success in a doctor of pharmacy program.
American journal of pharmaceutical education 2006;70(5):106.
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2006: Koziara J M; Lockman P R; Allen D D; Mumper R J
The blood-brain barrier and brain drug delivery.
Journal of nanoscience and nanotechnology 2006;6(9-10):2712-35.
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2006: Lockman Paul R; Gaasch Julie; McAfee Ghia; Abbruscato Thomas J; Van der Schyf Cornelis J; Allen David D
Nicotine exposure does not alter plasma to brain choline transfer.
Neurochemical research 2006;31(4):503-8.
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2006: Saud Katherine; Arriagada Christian; Cárdenas Ana María; Shimahara Takeshi; Allen David D; Caviedes Raúl; Caviedes Pablo
Neuronal dysfunction in Down syndrome: contribution of neuronal models in cell culture.
Journal of physiology, Paris 2006;99(2-3):201-10.
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2006: Geldenhuys Werner J; Gaasch Kevin E; Watson Mark; Allen David D; Van der Schyf Cornelis J
Optimizing the use of open-source software applications in drug discovery.
Drug discovery today 2006;11(3-4):127-32.
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2006: Allen David D; Geldenhuys Werner J
Molecular modeling of blood-brain barrier nutrient transporters: in silico basis for evaluation of potential drug delivery to the central nervous system.
Life sciences 2006;78(10):1029-33.
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2006: Paulson Jennifer R; Roder Karen E; McAfee Ghia; Allen David D; Van der Schyf Cornelis J; Abbruscato Thomas J
Tobacco smoke chemicals attenuate brain-to-blood potassium transport mediated by the Na,K,2Cl-cotransporter during hypoxia-reoxygenation.
The Journal of pharmacology and experimental therapeutics 2006;316(1):248-54.
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2005: Allen David D; Caviedes Raúl; Cárdenas Ana María; Shimahara Takeshi; Segura-Aguilar Juan; Caviedes Pablo A
Cell lines as in vitro models for drug screening and toxicity studies.
Drug development and industrial pharmacy 2005;31(8):757-68.
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2005: Lockman P R; McAfee G; Geldenhuys W J; Van der Schyf C J; Abbruscato T J; Allen D D
Brain uptake kinetics of nicotine and cotinine after chronic nicotine exposure.
The Journal of pharmacology and experimental therapeutics 2005;314(2):636-42.
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2005: Lockman P R; Van der Schyf C J; Abbruscato T J; Allen D D
Chronic nicotine exposure alters blood-brain barrier permeability and diminishes brain uptake of methyllycaconitine.
Journal of neurochemistry 2005;94(1):37-44.
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2005: Geldenhuys Werner J; Lockman Paul R; Nguyen Tiffany H; Van der Schyf Cornelis J; Crooks Peter A; Dwoskin Linda P; Allen David D
3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter.
Bioorganic & medicinal chemistry 2005;13(13):4253-61.
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2005: Geldenhuys Werner J; Lockman Paul R; Philip Ashok E; McAfee James H; Miller Bryan L; McCurdy Christopher R; Allen David D
Inhibition of choline uptake by N-cyclohexylcholine, a high affinity ligand for the choline transporter at the blood-brain barrier.
Journal of drug targeting 2005;13(4):259-66.
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2005: Cui Zhengrong; Lockman Paul R; Atwood Craig S; Hsu Cheng-Hsuan; Gupte Anshul; Allen David D; Mumper Russell J
Novel D-penicillamine carrying nanoparticles for metal chelation therapy in Alzheimer's and other CNS diseases.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2005;59(2):263-72.
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2004: Lockman Paul R; McAfee James H; Geldenhuys Werner J; Allen David D
Cation transport specificity at the blood-brain barrier.
Neurochemical research 2004;29(12):2245-50.
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2004: Koziara Joanna M; Lockman Paul R; Allen David D; Mumper Russell J
Paclitaxel nanoparticles for the potential treatment of brain tumors.
Journal of controlled release : official journal of the Controlled Release Society 2004;99(2):259-69.
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2004: Geldenhuys Werner J; Lockman Paul R; McAfee James H; Fitzpatrick Kevin T; Van der Schyf Cornelis J; Allen David D
Molecular modeling studies on the active binding site of the blood-brain barrier choline transporter.
Bioorganic & medicinal chemistry letters 2004;14(12):3085-92.
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2004: Crooks Peter A; Ayers Joshua T; Xu Rui; Sumithran Sangeetha P; Grinevich Vladimir P; Wilkins Lincoln H; Deaciuc A Gabriela; Allen David D; Dwoskin Linda P
Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.
Bioorganic & medicinal chemistry letters 2004;14(8):1869-74.
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2004: Lockman Paul R; Koziara Joanna M; Mumper Russell J; Allen David D
Nanoparticle surface charges alter blood-brain barrier integrity and permeability.
Journal of drug targeting 2004;12(9-10):635-41.
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2003: Lockman Paul R; Oyewumi Moses O; Koziara Joanna M; Roder Karen E; Mumper Russell J; Allen David D
Brain uptake of thiamine-coated nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society 2003;93(3):271-82.
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2003: Koziara Joanna M; Lockman Paul R; Allen David D; Mumper Russell J
In situ blood-brain barrier transport of nanoparticles.
Pharmaceutical research 2003;20(11):1772-8.
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2003: Allen D D; Lockman P R
The blood-brain barrier choline transporter as a brain drug delivery vector.
Life sciences 2003;73(13):1609-15.
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2003: Lockman P R; Mumper R J; Allen D D
Evaluation of blood-brain barrier thiamine efflux using the in situ rat brain perfusion method.
Journal of neurochemistry 2003;86(3):627-34.
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2003: Lockman Paul R; Koziara Joanna; Roder Karen E; Paulson Jennifer; Abbruscato Thomas J; Mumper Russell J; Allen David D
In vivo and in vitro assessment of baseline blood-brain barrier parameters in the presence of novel nanoparticles.
Pharmaceutical research 2003;20(5):705-13.
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2003: Allen David D; Lockman Paul R; Roder Karen E; Dwoskin Linda P; Crooks Peter A
Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter.
The Journal of pharmacology and experimental therapeutics 2003;304(3):1268-74.
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2003: Crossgrove Janelle S; Allen David D; Bukaveckas Bonny L; Rhineheimer Susan S; Yokel Robert A
Manganese distribution across the blood-brain barrier. I. Evidence for carrier-mediated influx of managanese citrate as well as manganese and manganese transferrin.
Neurotoxicology 2003;24(1):3-13.
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2003: Smith Quentin R; Allen David D
In situ brain perfusion technique.
Methods in molecular medicine 2003;89():209-18.
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2002: Cárdenas Ana María; Arriagada Christian; Allen David D; Caviedes Raúl; Cortes José F; Martin José; Couve Eduardo; Rapoport Stanley I; Shimahara Takeshi; Caviedes Pablo
Cell lines derived from hippocampal neurons of the normal and trisomy 16 mouse fetus (a model for Down syndrome) exhibit neuronal markers, cholinergic function, and functional neurotransmitter receptors.
Experimental neurology 2002;177(1):159-70.
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2002: Crowe A P; Lockman P R; Abbruscato T J; Allen D D
Novel choline transport characteristics in Caco-2 cells.
Drug development and industrial pharmacy 2002;28(7):773-81.
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2002: Lockman P R; Allen D D
The transport of choline.
Drug development and industrial pharmacy 2002;28(7):749-71.
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2002: Cárdenas Ana María; Allen David D; Arriagada Christian; Olivares Alexis; Bennett Lori B; Caviedes Raúl; Dagnino-Subiabre Alexies; Mendoza Isabel E; Segura-Aguilar Juan; Rapoport Stanley I; Caviedes Pablo
Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome.
Journal of neuroscience research 2002;68(1):46-58.
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2002: Allen David D; Cárdenas Ana María; Arriagada Christian; Bennett Lori B; García Carlos J; Caviedes Raúl; Rapoport Stanley I; Caviedes Pablo
A dorsal root ganglia cell line derived from trisomy 16 fetal mice, a model for Down syndrome.
Neuroreport 2002;13(4):491-6.
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2002: Lockman P R; Mumper R J; Khan M A; Allen D D
Nanoparticle technology for drug delivery across the blood-brain barrier.
Drug development and industrial pharmacy 2002;28(1):1-13.
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2001: Lockman P R; Roder K E; Allen D D
Inhibition of the rat blood-brain barrier choline transporter by manganese chloride.
Journal of neurochemistry 2001;79(3):588-94.
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2001: Allen D D; Bond C A
Prepharmacy predictors of success in pharmacy school: grade point averages, pharmacy college admissions test, communication abilities, and critical thinking skills.
Pharmacotherapy 2001;21(7):842-9.
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2001: Allen D D; Smith Q R
Characterization of the blood-brain barrier choline transporter using the in situ rat brain perfusion technique.
Journal of neurochemistry 2001;76(4):1032-41.
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2001: Rojas-Fernandez C H; Lanctot K L; Allen D D; MacKnight C
Pharmacotherapy of behavioral and psychological symptoms of dementia: time for a different paradigm?
Pharmacotherapy 2001;21(1):74-102.
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2000: Allen D D; Martín J; Arriagada C; Cárdenas A M; Rapoport S I; Caviedes R; Caviedes P
Impaired cholinergic function in cell lines derived from the cerebral cortex of normal and trisomy 16 mice.
The European journal of neuroscience 2000;12(9):3259-64.
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1999: Allen D D; Smith Q R
Blood-brain barrier choline transport in the senescent rat.
Neuroscience letters 1999;277(3):198-202.
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1999: Yokel R A; Allen D D; Ackley D C
The distribution of aluminum into and out of the brain.
Journal of inorganic biochemistry 1999;76(2):127-32.
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1998: Metting T L; Burgio D E; Terry A V; Beach J W; McCurdy C R; Allen D D
Inhibition of brain choline uptake by isoarecolone and lobeline derivatives: implications for potential vector-mediated brain drug delivery.
Neuroscience letters 1998;258(1):25-8.
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1997: Allen D D; Galdzicki Z; Brining S K; Fukuyama R; Rapoport S I; Smith Q R
Beta-amyloid induced increase in choline flux across PC12 cell membranes.
Neuroscience letters 1997;234(1):71-3.
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1996: Meyer J J; Allen D D; Yokel R A
Hippocampal acetylcholine increases during eyeblink conditioning in the rabbit.
Physiology & behavior 1996;60(5):1199-203.
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1996: Fredenburg A M; Sethi R K; Allen D D; Yokel R A
The pharmacokinetics and blood-brain barrier permeation of the chelators 1,2 dimethly-, 1,2 diethyl-, and 1-[ethan-1'ol]-2-methyl-3-hydroxypyridin-4-one in the rat.
Toxicology 1996;108(3):191-9.
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1995: Allen D D; Orvig C; Yokel R A
Evidence for energy-dependent transport of aluminum out of brain extracellular fluid.
Toxicology 1995;98(1-3):31-9.
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1994: Yokel R A; Allen D D; Meyer J J
Studies of aluminum neurobehavioral toxicity in the intact mammal.
Cellular and molecular neurobiology 1994;14(6):791-808.
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1994: Allen D D; Orvig C; Yokel R A
Pharmacokinetics of aluminum 3-hydroxypyridin-4-one complexes: implications for aluminum redistribution subsequent to chelation therapy.
Toxicology 1994;92(1-3):193-202.
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1994: Allen D D; Orvig C; Yokel R A
Pharmacokinetics and distribution of tris(maltolato)aluminum(III) into the central nervous system.
Neurotoxicology 1994;15(2):371-8.
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1992: Allen D D; Crooks P A; Yokel R A
4-Trimethylammonium antipyrine: a quaternary ammonium nonradionuclide marker for blood-brain barrier integrity during in vivo microdialysis.
Journal of pharmacological and toxicological methods 1992;28(3):129-35.
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1992: Yokel R A; Allen D D; Burgio D E; McNamara P J
Antipyrine as a dialyzable reference to correct differences in efficiency among and within sampling devices during in vivo microdialysis.
Journal of pharmacological and toxicological methods 1992;27(3):135-42.
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1992: Allen D D; Yokel R A
Dissimilar aluminum and gallium permeation of the blood-brain barrier demonstrated by in vivo microdialysis.
Journal of neurochemistry 1992;58(3):903-8.
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