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Simon Cook

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Anatomy

Phenomena

Phosphorylation

Physiology

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Co-Publications
Name
16
Balmanno, Kathryn
6
Hadfield, Kathryn
5
Ley, Rebecca
5
Todd, Daniel
5
Weston, Claire
4
Wiggins, Ceri
4
Chalmers, Claire
4
Garner, Andrew
4
Ewings, Katherine
4
Molton, Sarah
1
Palmer, Timothy
1
Park, Jong-Hwan
1
Hemberger, Myriam
1
Inohara, Naohiro
1
Keyse, Stephen

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Publications

TOP 3
Krueger Felix; Madeja Zofia; Hemberger Myriam; McMahon Martin; Cook Simon J; Gaunt Stephen J
Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway.
Gillings Annette S; Balmanno Kathryn; Wiggins Ceri M; Johnson Mark; Cook Simon J
Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics.
Balmanno Kathryn; Chell Simon D; Gillings Annette S; Hayat Shaista; Cook Simon J
Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines.

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All Publications

2009: Krueger Felix; Madeja Zofia; Hemberger Myriam; McMahon Martin; Cook Simon J; Gaunt Stephen J
Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway.
Cellular signalling 2009;21(12):1846-56.
2009: Gillings Annette S; Balmanno Kathryn; Wiggins Ceri M; Johnson Mark; Cook Simon J
Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics.
The FEBS journal 2009;276(21):6050-62.
2009: Balmanno Kathryn; Chell Simon D; Gillings Annette S; Hayat Shaista; Cook Simon J
Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines.
International journal of cancer. Journal international du cancer 2009;125(10):2332-41.
2009: Gilley Rebecca; March H Nikki; Cook Simon J
ERK1/2, but not ERK5, is necessary and sufficient for phosphorylation and activation of c-Fos.
Cellular signalling 2009;21(6):969-77.
2009: Balmanno K; Cook S J
Tumour cell survival signalling by the ERK1/2 pathway.
Cell death and differentiation 2009;16(3):368-77.
2009: Berwick Daniel C; Calissano Mattia; Corness Jacqueline D; Cook Simon J; Latchman David S
Regulation of Brn-3a N-terminal transcriptional activity by MEK1/2-ERK1/2 signalling in neural differentiation.
Brain research 2009;1256():8-18.
2008: Densham Ruth M; Todd Daniel E; Balmanno Kathy; Cook Simon J
ERK1/2 and p38 cooperate to delay progression through G1 by promoting cyclin D1 protein turnover.
Cellular signalling 2008;20(11):1986-94.
2008: Arkell Rebecca S; Dickinson Robin J; Squires Matthew; Hayat Shaista; Keyse Stephen M; Cook Simon J
DUSP6/MKP-3 inactivates ERK1/2 but fails to bind and inactivate ERK5.
Cellular signalling 2008;20(5):836-43.
2007: Wiggins Ceri M; Band Hamid; Cook Simon J
c-Cbl is not required for ERK1/2-dependent degradation of BimEL.
Cellular signalling 2007;19(12):2605-11.
2007: Ewings Katherine E; Wiggins Ceri M; Cook Simon J
Bim and the pro-survival Bcl-2 proteins: opposites attract, ERK repels.
Cell cycle (Georgetown, Tex.) 2007;6(18):2236-40.
2007: Ewings Katherine E; Hadfield-Moorhouse Kathryn; Wiggins Ceri M; Wickenden Julie A; Balmanno Kathryn; Gilley Rebecca; Degenhardt Kurt; White Eileen; Cook Simon J
ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL.
The EMBO journal 2007;26(12):2856-67.
2007: Cook Simon J; Morley Simon J
Nutrient-responsive mTOR signalling grows on Sterile ground.
The Biochemical journal 2007;403(1):e1-3.
2007: Turner Suzanne D; Yeung Debra; Hadfield Kathryn; Cook Simon J; Alexander Denis R
The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT and AP-1 by RAS-dependent mechanisms.
Cellular signalling 2007;19(4):740-7.
2007: Chalmers Claire J; Gilley Rebecca; March Helen N; Balmanno Kathryn; Cook Simon J
The duration of ERK1/2 activity determines the activation of c-Fos and Fra-1 and the composition and quantitative transcriptional output of AP-1.
Cellular signalling 2007;19(4):695-704.
2006: Boughan Parjeet K; Argent Richard H; Body-Malapel Mathilde; Park Jong-Hwan; Ewings Katie E; Bowie Andrew G; Ong Shao Jin; Cook Simon J; Sorensen Ole E; Manzo Barbara A; Inohara Naohiro; Klein Nigel J; Nuñez Gabriel; Atherton John C; Bajaj-Elliott Mona
Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection.
The Journal of biological chemistry 2006;281(17):11637-48.
2005: Molton Sarah A; Weston Claire; Balmanno Kathryn; Newson Catherine; Todd Daniel E; Garner Andrew P; Cook Simon J
The conditional kinase DeltaMEKK1:ER* selectively activates the JNK pathway and protects against serum withdrawal-induced cell death.
Cellular signalling 2005;17(11):1412-22.
2005: Austin Mark; Cook Simon J
Increased expression of Mcl-1 is required for protection against serum starvation in phosphatase and tensin homologue on chromosome 10 null mouse embryonic fibroblasts, but repression of Bim is favored in human glioblastomas.
The Journal of biological chemistry 2005;280(39):33280-8.
2005: Ley Rebecca; Hadfield Kathryn; Howes Elizabeth; Cook Simon J
Identification of a DEF-type docking domain for extracellular signal-regulated kinases 1/2 that directs phosphorylation and turnover of the BH3-only protein BimEL.
The Journal of biological chemistry 2005;280(18):17657-63.
2004: Todd Daniel E; Densham Ruth M; Molton Sarah A; Balmanno Kathryn; Newson Catherine; Weston Claire R; Garner Andrew P; Scott Linda; Cook Simon J
ERK1/2 and p38 cooperate to induce a p21CIP1-dependent G1 cell cycle arrest.
Oncogene 2004;23(19):3284-95.
2004: Ley Rebecca; Ewings Katherine E; Hadfield Kathryn; Howes Elizabeth; Balmanno Kathryn; Cook Simon J
Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover.
The Journal of biological chemistry 2004;279(10):8837-47.
2003: Balmanno Kathryn; Millar Tracy; McMahon Martin; Cook Simon J
DeltaRaf-1:ER* bypasses the cyclic AMP block of extracellular signal-regulated kinase 1 and 2 activation but not CDK2 activation or cell cycle reentry.
Molecular and cellular biology 2003;23(24):9303-17.
2003: Chalmers Claire J; Balmanno Kathryn; Hadfield Kathryn; Ley Rebecca; Cook Simon J
Thrombin inhibits Bim (Bcl-2-interacting mediator of cell death) expression and prevents serum-withdrawal-induced apoptosis via protease-activated receptor 1.
The Biochemical journal 2003;375(Pt 1):99-109.
2003: Molton Sarah A; Todd Daniel E; Cook Simon J
Selective activation of the c-Jun N-terminal kinase (JNK) pathway fails to elicit Bax activation or apoptosis unless the phosphoinositide 3'-kinase (PI3K) pathway is inhibited.
Oncogene 2003;22(30):4690-701.
2003: Ley Rebecca; Balmanno Kathryn; Hadfield Kathryn; Weston Claire; Cook Simon J
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.
The Journal of biological chemistry 2003;278(21):18811-6.
2003: Weston Claire R; Balmanno Kathryn; Chalmers Claire; Hadfield Kathryn; Molton Sarah A; Ley Rebecca; Wagner Erwin F; Cook Simon J
Activation of ERK1/2 by deltaRaf-1:ER* represses Bim expression independently of the JNK or PI3K pathways.
Oncogene 2003;22(9):1281-93.
2002: Garner Andrew P; Weston Claire R; Todd Daniel E; Balmanno Kathryn; Cook Simon J
Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint.
Oncogene 2002;21(53):8089-104.
2002: Squires Matthew S; Nixon Paula M; Cook Simon J
Cell-cycle arrest by PD184352 requires inhibition of extracellular signal-regulated kinases (ERK) 1/2 but not ERK5/BMK1.
The Biochemical journal 2002;366(Pt 2):673-80.
2002: Watterson Kenneth R; Johnston Evelyn; Chalmers Claire; Pronin Alexey; Cook Simon J; Benovic Jeffrey L; Palmer Timothy M
Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2.
The Journal of biological chemistry 2002;277(8):5767-77.
2000: Cook S J; Balmanno K; Garner A; Millar T; Taverner C; Todd D
Regulation of cell cycle re-entry by growth, survival and stress signalling pathways.
Biochemical Society transactions 2000;28(2):233-40.
1999: Balmanno K; Cook S J
Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells.
Oncogene 1999;18(20):3085-97.

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