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Howard Cooke

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Mice

Chemicals & Drugs

Anatomy

Physiology

Spermatogenesis

Concepts & Ideas

Procedures

Devices

Chromosomes, Artificial, Yeast

Disorders

Male Infertility

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Network (preview)

Co-Publications
Name
12
Speed, Robert
10
Ross, Andrew
9
Elliott, David
8
McGill, Niolette
7
Ruggiu, M
7
Taggart, Mary
7
Hargreave, Timothy
6
Grimes, BR
6
Chandley, AC
6
Costa, Yael
5
Maratou, Klio
5
Venables, Julian
5
Saunders, Philippa
4
Reynolds, Nicola
4
de las Heras, Jose

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Publications

TOP 3
Ollinger Rupert; Childs Andrew J; Burgess Hannah M; Speed Robert M; Lundegaard Pia R; Reynolds Nicola; Gray Nicola K; Cooke Howard J; Adams Ian R
Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice.
Reynolds Nicola; Collier Brian; Bingham Victoria; Gray Nicola K; Cooke Howard J
Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl.
Bolcun-Filas Ewelina; Costa Yael; Speed Robert; Taggart Mary; Benavente Ricardo; De Rooij Dirk G; Cooke Howard J
SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination.

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All Publications

2008: Ollinger Rupert; Childs Andrew J; Burgess Hannah M; Speed Robert M; Lundegaard Pia R; Reynolds Nicola; Gray Nicola K; Cooke Howard J; Adams Ian R
Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice.
PLoS genetics 2008;4(9):e1000199.
2007: Reynolds Nicola; Collier Brian; Bingham Victoria; Gray Nicola K; Cooke Howard J
Translation of the synaptonemal complex component Sycp3 is enhanced in vivo by the germ cell specific regulator Dazl.
RNA (New York, N.Y.) 2007;13(7):974-81.
2007: Bolcun-Filas Ewelina; Costa Yael; Speed Robert; Taggart Mary; Benavente Ricardo; De Rooij Dirk G; Cooke Howard J
SYCE2 is required for synaptonemal complex assembly, double strand break repair, and homologous recombination.
The Journal of cell biology 2007;176(6):741-7.
2007: Costa Yael; Cooke Howard J
Dissecting the mammalian synaptonemal complex using targeted mutations.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 2007;15(5):579-89.
2006: Costa Yael; Speed Robert M; Gautier Philippe; Semple Colin A; Maratou Klio; Turner James M A; Cooke Howard J
Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?
Human molecular genetics 2006;15(15):2324-34.
2005: Reynolds Nicola; Collier Brian; Maratou Klio; Bingham Victoria; Speed Robert M; Taggart Mary; Semple Colin A; Gray Nicola K; Cooke Howard J
Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells.
Human molecular genetics 2005;14(24):3899-909.
2005: Collier Brian; Gorgoni Barbara; Loveridge Carolyn; Cooke Howard J; Gray Nicola K
The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells.
The EMBO journal 2005;24(14):2656-66.
2005: Costa Yael; Speed Robert; Ollinger Rupert; Alsheimer Manfred; Semple Colin A; Gautier Philippe; Maratou Klio; Novak Ivana; Höög Christer; Benavente Ricardo; Cooke Howard J
Two novel proteins recruited by synaptonemal complex protein 1 (SYCP1) are at the centre of meiosis.
Journal of cell science 2005;118(Pt 12):2755-62.
2005: Kotzamanis George; Cheung Wing; Abdulrazzak Hassan; Perez-Luz Sara; Howe Steven; Cooke Howard; Huxley Clare
Construction of human artificial chromosome vectors by recombineering.
Gene 2005;351():29-38.
2005: Reynolds Nicola; Cooke Howard J
Role of the DAZ genes in male fertility.
Reproductive biomedicine online 2005;10(1):72-80.
2004: Zeng Kang; de las Heras Jose I; Ross Andrew; Yang Jian; Cooke Howard; Shen Ming Hong
Localisation of centromeric proteins to a fraction of mouse minor satellite DNA on a mini-chromosome in human, mouse and chicken cells.
Chromosoma 2004;113(2):84-91.
2004: Cooke Howard J
Silence of the centromeres--not.
Trends in biotechnology 2004;22(7):319-21.
2004: Forster Thorsten; Costa Yael; Roy Douglas; Cooke Howard J; Maratou Klio
Triple-target microarray experiments: a novel experimental strategy.
BMC genomics 2004;5(1):13.
2004: Magin-Lachmann C; Kotzamanis G; D'Aiuto L; Cooke H; Huxley C; Wagner E
In vitro and in vivo delivery of intact BAC DNA -- comparison of different methods.
The journal of gene medicine 2004;6(2):195-209.
2004: Maratou Klio; Forster Thorsten; Costa Yael; Taggart Mary; Speed Robert M; Ireland John; Teague Peter; Roy Douglas; Cooke Howard J
Expression profiling of the developing testis in wild-type and Dazl knockout mice.
Molecular reproduction and development 2004;67(1):26-54.
2004: de las Heras Jose I; D'Aiuto Leonardo; Cooke Howard
Mammalian artificial chromosome formation in human cells after lipofection of a PAC precursor.
Methods in molecular biology (Clifton, N.J.) 2004;240():187-206.
2003: D'Aiuto Leonardo; de las Heras Jose I; Ross Andrew; Shen Ming Hong; Cooke Howard
Generation of a telomere-based episomal vector.
Biotechnology progress 2003;19(6):1775-80.
2003: Rilianawati; Speed R; Taggart M; Cooke H J
Spermatogenesis in testes of Dazl null mice after transplantation of wild-type germ cells.
Reproduction (Cambridge, England) 2003;126(5):599-604.
2003: Saunders P T K; Turner J M A; Ruggiu M; Taggart M; Burgoyne P S; Elliott D; Cooke H J
Absence of mDazl produces a final block on germ cell development at meiosis.
Reproduction (Cambridge, England) 2003;126(5):589-97.
2002: Cooke Howard J; Saunders Philippa T K
Mouse models of male infertility.
Nature reviews. Genetics 2002;3(10):790-801.
2002: Vogel T; Speed R M; Ross A; Cooke H J
Partial rescue of the Dazl knockout mouse by the human DAZL gene.
Molecular human reproduction 2002;8(9):797-804.
2001: Shen M H; Ross A; Yang J; de las Heras J I; Cooke H
Neo-centromere formation on a 2.6 Mb mini-chromosome in DT40 cells.
Chromosoma 2001;110(6):421-9.
2001: Grimes B R; Schindelhauer D; McGill N I; Ross A; Ebersole T A; Cooke H J
Stable gene expression from a mammalian artificial chromosome.
EMBO reports 2001;2(10):910-4.
2001: Venables J P; Ruggiu M; Cooke H J
The RNA-binding specificity of the mouse Dazl protein.
Nucleic acids research 2001;29(12):2479-83.
2001: Cooke H
Mammalian artificial chromosomes as vectors: progress and prospects.
Cloning and stem cells 2001;3(4):243-9.
2000: Paracchini S; Stuppia L; Gatta V; Palka G; Moro E; Foresta C; Mengua L; Oliva R; Ballescà J L; Kremer J A; van Golde R J; Tuerlings J H; Hargreave T; Ross A; Cooke H; Huellen K; Vogt P H; Tyler-Smith C
Y-chromosomal DNA haplotypes in infertile European males carrying Y-microdeletions.
Journal of endocrinological investigation 2000;23(10):671-6.
2000: Venables J P; Cooke H J
Lessons from knockout and transgenic mice for infertility in men.
Journal of endocrinological investigation 2000;23(9):584-91.
2000: Elliott D J; Venables J P; Newton C S; Lawson D; Boyle S; Eperon I C; Cooke H J
An evolutionarily conserved germ cell-specific hnRNP is encoded by a retrotransposed gene.
Human molecular genetics 2000;9(14):2117-24.
2000: Ruggiu M; Cooke H J
In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein.
Gene 2000;252(1-2):119-26.
2000: Ebersole T A; Ross A; Clark E; McGill N; Schindelhauer D; Cooke H; Grimes B
Mammalian artificial chromosome formation from circular alphoid input DNA does not require telomere repeats.
Human molecular genetics 2000;9(11):1623-31.
2000: Elliott D J; Bourgeois C F; Klink A; Stévenin J; Cooke H J
A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5717-22.
2000: Ruggiu M; Saunders P T; Cooke H J
Dynamic subcellular distribution of the DAZL protein is confined to primate male germ cells.
Journal of andrology 2000;21(3):470-7.
2000: Venables J P; Elliott D J; Makarova O V; Makarov E M; Cooke H J; Eperon I C
RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing.
Human molecular genetics 2000;9(5):685-94.
1999: Vogel T; Speed R M; Teague P; Cooke H J
Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype.
Human reproduction (Oxford, England) 1999;14(12):3023-9.
1999: Slee R; Grimes B; Speed R M; Taggart M; Maguire S M; Ross A; McGill N I; Saunders P T; Cooke H J
A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8040-5.
1999: Venables J P; Vernet C; Chew S L; Elliott D J; Cowmeadow R B; Wu J; Cooke H J; Artzt K; Eperon I C
T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis.
Human molecular genetics 1999;8(6):959-69.
1999: Ruggiu M; Cooke H
Y bind RNA for spermatogenesis?
International journal of andrology 1999;22(1):19-27.
1999: Cooke H J
Y chromosome and male infertility.
Reviews of reproduction 1999;4(1):5-10.
1998: Masumoto H; Ikeno M; Nakano M; Okazaki T; Grimes B; Cooke H; Suzuki N
Assay of centromere function using a human artificial chromosome.
Chromosoma 1998;107(6-7):406-16.
1998: Hargreave T B; Ghosh C; Cooke H
Genetics of male infertility.
Molecular and cellular endocrinology 1998;145(1-2):143-51.
1998: Cooke H J; Hargreave T; Elliott D J
Understanding the genes involved in spermatogenesis: a progress report.
Fertility and sterility 1998;69(6):989-95.
1998: Ikeno M; Grimes B; Okazaki T; Nakano M; Saitoh K; Hoshino H; McGill N I; Cooke H; Masumoto H
Construction of YAC-based mammalian artificial chromosomes.
Nature biotechnology 1998;16(5):431-9.
1998: Elliott D J; Oghene K; Makarov G; Makarova O; Hargreave T B; Chandley A C; Eperon I C; Cooke H J
Dynamic changes in the subnuclear organisation of pre-mRNA splicing proteins and RBM during human germ cell development.
Journal of cell science 1998;111 ( Pt 9)():1255-65.
1998: Grimes B; Cooke H
Engineering mammalian chromosomes.
Human molecular genetics 1998;7(10):1635-40.
1997: Elliott D J; Cooke H J
The molecular genetics of male infertility.
BioEssays : news and reviews in molecular, cellular and developmental biology 1997;19(9):801-9.
1997: Ruggiu M; Speed R; Taggart M; McKay S J; Kilanowski F; Saunders P; Dorin J; Cooke H J
The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis.
Nature 1997;389(6646):73-7.
1997: Warburton P E; Cooke H J
Hamster chromosomes containing amplified human alpha-satellite DNA show delayed sister chromatid separation in the absence of de novo kinetochore formation.
Chromosoma 1997;106(3):149-59.
1997: Schindelhauer D; Cooke H J
Efficient combination of large DNA in vitro: in gel site specific recombination (IGSSR) of PAC fragments containing alpha satellite DNA and the human HPRT gene locus.
Nucleic acids research 1997;25(11):2241-3.
1997: Klink A; Lee M; Cooke H J
The mouse synaptosomal complex protein gene Sycp3 maps to band C of chromosome 10.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(5):376-7.
1997: Elliott D J; Millar M R; Oghene K; Ross A; Kiesewetter F; Pryor J; McIntyre M; Hargreave T B; Saunders P T; Vogt P H; Chandley A C; Cooke H
Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(8):3848-53.
1996: Prosser J; Inglis J D; Condie A; Ma K; Kerr S; Thakrar R; Taylor K; Cameron J M; Cooke H J
Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(11):835-42.
1996: Qureshi S J; Ross A R; Ma K; Cooke H J; Intyre M A; Chandley A C; Hargreave T B
Polymerase chain reaction screening for Y chromosome microdeletions: a first step towards the diagnosis of genetically-determined spermatogenic failure in men.
Molecular human reproduction 1996;2(10):775-9.
1996: Kerr S M; Taggart M H; Lee M; Cooke H J
Ott, a mouse X-linked multigene family expressed specifically during meiosis.
Human molecular genetics 1996;5(8):1139-48.
1996: Elliott D J; Ma K; Kerr S M; Thakrar R; Speed R; Chandley A C; Cooke H
An RBM homologue maps to the mouse Y chromosome and is expressed in germ cells.
Human molecular genetics 1996;5(7):869-74.
1996: Kipling D; Salido E C; Shapiro L J; Cooke H J
High frequency de novo alterations in the long-range genomic structure of the mouse pseudoautosomal region.
Nature genetics 1996;13(1):78-80.
1996: Cooke H J; Lee M; Kerr S; Ruggiu M
A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonads.
Human molecular genetics 1996;5(4):513-6.
1996: Kerr S M; Taggart M H; Lee M; Cooke H J
Sequence and mapping of mouse synaptonemal complex protein genes Sycpl and Sycpl-rs.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(3):209-11.
1996: Kipling D; Wilson H E; Thomson E J; Lee M; Perry J; Palmer S; Ashworth A; Cooke H J
Structural variation of the pseudoautosomal region between and within inbred mouse strains.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):171-5.
1996: Hargreave T B; Chandley A C; Ross A; Qureshi S; Kun M; Cooke H
Y chromosome microdeletions and male subfertility.
Andrologia 1996;28 Suppl 1():19-21.
1995: Farr C J; Bayne R A; Kipling D; Mills W; Critcher R; Cooke H J
Generation of a human X-derived minichromosome using telomere-associated chromosome fragmentation.
The EMBO journal 1995;14(21):5444-54.
1995: Kipling D; Mitchell A R; Masumoto H; Wilson H E; Nicol L; Cooke H J
CENP-B binds a novel centromeric sequence in the Asian mouse Mus caroli.
Molecular and cellular biology 1995;15(8):4009-20.
1995: Kipling D; Wilson H E; Thomson E J; Cooke H J
YAC cloning Mus musculus telomeric DNA: physical, genetic, in situ and STS markers for the distal telomere of chromosome 10.
Human molecular genetics 1995;4(6):1007-14.
1994: Kerr S M; Vambrie S; McKay S J; Cooke H J
Analysis of cDNA sequences from mouse testis.
Mammalian genome : official journal of the International Mammalian Genome Society 1994;5(9):557-65.
1994: McKay S; Thomson E; Cooke H
Sequence homologies and linkage group conservation of the human and mouse Cenpc genes.
Genomics 1994;22(1):36-40.
1994: Broccoli D; Cooke H J
Effect of telomeres on the interphase location of adjacent regions of the human X chromosome.
Experimental cell research 1994;212(2):308-13.
1994: Bayne R A; Broccoli D; Taggart M H; Thomson E J; Farr C J; Cooke H J
Sandwiching of a gene within 12 kb of a functional telomere and alpha satellite does not result in silencing.
Human molecular genetics 1994;3(4):539-46.
1994: Kipling D; Wilson H E; Mitchell A R; Taylor B A; Cooke H J
Mouse centromere mapping using oligonucleotide probes that detect variants of the minor satellite.
Chromosoma 1994;103(1):46-55.
1994: Allshire R C; Cooke H J
Chromosome substructure investigation. Telomeres.
Methods in molecular biology (Clifton, N.J.) 1994;29():493-503.
1994: Chandley A C; Cooke H J
Human male fertility--Y-linked genes and spermatogenesis.
Human molecular genetics 1994;3 Spec No():1449-52.
1993: Cooke H
DNA and police files.
Lancet 1993;342(8864):130.
1992: Farr C J; Stevanovic M; Thomson E J; Goodfellow P N; Cooke H J
Telomere-associated chromosome fragmentation: applications in genome manipulation and analysis.
Nature genetics 1992;2(4):275-82.
1992: McGill N I; Fantes J; Cooke H
Lambda CM8, a human sequence with putative centromeric function, does not map to the centromere but is present in one to two copies at 9qter.
Human molecular genetics 1992;1(9):749-51.
1992: McKay S J; Cooke H
hnRNP A2/B1 binds specifically to single stranded vertebrate telomeric repeat TTAGGGn.
Nucleic acids research 1992;20(24):6461-4.
1992: Kipling D; Cooke H J
Beginning or end? Telomere structure, genetics and biology.
Human molecular genetics 1992;1(1):3-6.
1992: McKay S J; Cooke H
A protein which specifically binds to single stranded TTAGGGn repeats.
Nucleic acids research 1992;20(6):1387-91.
1992: Cooke H
Using chromosome features in genome mapping.
Trends in biotechnology 1992;10(1-2):23-6.
1991: Kipling D; Ackford H E; Taylor B A; Cooke H J
Mouse minor satellite DNA genetically maps to the centromere and is physically linked to the proximal telomere.
Genomics 1991;11(2):235-41.
1991: Farr C; Fantes J; Goodfellow P; Cooke H
Functional reintroduction of human telomeres into mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(16):7006-10.
1991: Lindsey J; McGill N I; Lindsey L A; Green D K; Cooke H J
In vivo loss of telomeric repeats with age in humans.
Mutation research 1991;256(1):45-8.
1990: Cross S; Lindsey J; Fantes J; McKay S; McGill N; Cooke H
The structure of a subterminal repeated sequence present on many human chromosomes.
Nucleic acids research 1990;18(22):6649-57.
1990: Cooke H
The continuing search for the mammalian sex-determining gene.
Trends in genetics : TIG 1990;6(9):273-5.
1990: Kipling D; Cooke H J
Hypervariable ultra-long telomeres in mice.
Nature 1990;347(6291):400-2.
1989: Cross S H; Allshire R C; McKay S J; McGill N I; Cooke H J
Cloning of human telomeres by complementation in yeast.
Nature 1989;338(6218):771-4.
1988: Cooke H; Cross S
pYAC-4 Neo, a yeast artificial chromosome vector which codes for G418 resistance in mammalian cells.
Nucleic acids research 1988;16(24):11817.
1983: Fantes J A; Green D K; Cooke H J
Purifying human Y chromosomes by flow cytometry and sorting.
Cytometry 1983;4(1):88-91.

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