FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Charles Coombes

Research Profile

Disorders

Chemicals & Drugs

Procedures

Anatomy

Concepts & Ideas

Physiology

Gene Expression Regulation, Neoplastic

Co-author Network

Publications

TOP 3
David S Guttery; Allison Hills; Stephanie D Marchese; Karen Page; Kevin Blighe; R Charles Coombes; Justin Stebbing; Jacqueline A Shaw
Hide and seek: tell-tale signs of breast cancer lurking in the blood.
Belinda Lee; Jacqueline S Lewis; Adrian K P Lim; Keshthra Satchithananda; R Charles Coombes; Jonathan Krell; Justin Stebbing
The efficacy of axillary ultrasound in the detection of nodal metastasis in breast cancer.
Darren K Patten; Zubair Wani; Susan J Cleator; R Charles Coombes; Daniel R Leff; Carlo Palmieri; Dimitri J Hadjiminas
Is the presence of small volume disease in the sentinel node an indication for axillary clearance?

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Charles Coombes (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: David S Guttery; Allison Hills; Stephanie D Marchese; Karen Page; Kevin Blighe; R Charles Coombes; Justin Stebbing; Jacqueline A Shaw
Hide and seek: tell-tale signs of breast cancer lurking in the blood.
Cancer metastasis reviews 2013;32(1-2):289-302.
2013: Belinda Lee; Jacqueline S Lewis; Adrian K P Lim; Keshthra Satchithananda; R Charles Coombes; Jonathan Krell; Justin Stebbing
The efficacy of axillary ultrasound in the detection of nodal metastasis in breast cancer.
AJR. American journal of roentgenology 2013;200(3):W314-20.
2013: Darren K Patten; Zubair Wani; Susan J Cleator; R Charles Coombes; Daniel R Leff; Carlo Palmieri; Dimitri J Hadjiminas
Is the presence of small volume disease in the sentinel node an indication for axillary clearance?
Breast (Edinburgh, Scotland) 2013;22(1):70-3.
2013: Justin Stebbing; Laura Woodley; Miranda Avery; Angelo Di Leo; Adam E Frampton; Jonathan Krell; Rachel Payne; Marta Pestrin; Justine Reise; R Charles Coombes
The Efficacy of Lapatinib in Metastatic Breast Cancer with HER2 Non-Amplified Primary Tumors and EGFR Positive Circulating Tumor Cells: A Proof-Of-Concept Study.
PloS one 2013;8(5):e62543.
2013: Gordon Mallarkey; R Charles Coombes
Targeted therapies in medical oncology: successes, failures and next steps.
Therapeutic advances in medical oncology 2013;5(1):5-16.
2012: Ylenia Lombardo; Loren Michel; Gemma Molyneux; Manikandan Periyasamy; Pritesh S Trivedi; Jayson Wang; Ernesto Yagüe; Aleksandra Filipović; Georgios Giamas; Yunhui Hu; R Charles Coombes
Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(41):16558-63.
2012: Gordon Mallarkey; R Charles Coombes
Pathways and biomarkers in breast cancer: latest evidence.
Therapeutic advances in medical oncology 2012;4(4):157-66.
2012: Kaiyumars Contractor; R Charles Coombes; Laura Kenny; Stephen Mangar; Carlo Palmieri; Pippa Riddle; Lula Rosso; Rohini Sharma; Justin Stebbing; Giampaolo Tomasi; Federico E Turkheimer; Harpreet Wasan; Adil Al-Nahhas; Amarnath Challapalli; Eric Aboagye
Imaging of cellular proliferation in liver metastasis by [18F]fluorothymidine positron emission tomography: effect of therapy.
Physics in medicine and biology 2012;57(11):3419-33.
2012: R E Payne; N Su; F Wang; E Yagüe; A Zebrowski; J Krell; Y Luo; X-J Ma; R Charles Coombes
Viable circulating tumour cell detection using multiplex RNA in situ hybridisation predicts progression-free survival in metastatic breast cancer patients.
British journal of cancer 2012;106(11):1790-7.
2012: Kaiyumars Contractor; R Charles Coombes; Jimmy Jacob; Eric O Aboagye; Amarnath Challapalli; Justin Stebbing
Monitoring early response to taxane therapy in advanced breast cancer with circulating tumor cells and [(18)F] 3´-deoxy-3´-fluorothymidine PET: a pilot study.
Biomarkers in medicine 2012;6(2):231-3.
2012: J Sven D Mieog; James P Morden; Cornelis J H van de Velde; Judith M Bliss; R Charles Coombes
Carpal tunnel syndrome and musculoskeletal symptoms in postmenopausal women with early breast cancer treated with exemestane or tamoxifen after 2-3 years of tamoxifen: a retrospective analysis of the Intergroup Exemestane Study.
The lancet oncology 2012;13(4):420-32.
2012: Justin Stebbing; Tingting Wang; Andrew R Green; Soo-Chin Lee; Heinz-Josef Lenz; R Charles Coombes; Tanya Rapoz D'Silva; Ian O Ellis; Aleksandra Filipovic; Georgios Giamas
LMTK3 expression in breast cancer: association with tumor phenotype and clinical outcome.
Breast cancer research and treatment 2012;132(2):537-44.
2012: Judith M Bliss; Laura Cisar; Alan S Coates; Robert E Coleman; Jørn Andersen; Thierry Delozier; John F Forbes; Jacek Jassem; Stephen E Jones; Lucy S Kilburn; Per E Lønning; Thomas Menschik; James Morden; Robert Paridaens; Justine Reise; Cornelis J H van de Velde; R Charles Coombes
Disease-related outcomes with long-term follow-up: an updated analysis of the intergroup exemestane study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(7):709-17.
2012: Jacqueline A Shaw; Justin Stebbing; Rosemary A Walker; Becky Ward; Kevin Blighe; James Brown; Suzy Cleator; David Guttery; Natasha Hava; Karen Page; Carlo Palmieri; Rachel Payne; Chetana Ruangpratheep; R Charles Coombes
Genomic analysis of circulating cell-free DNA infers breast cancer dormancy.
Genome research 2012;22(2):220-31.
2012: Carlo Palmieri; David Shipway; Tri Tat; Vivienne Watson; Constantine Alifrangis; Marie Emson; Diane Mackie; R Charles Coombes
A randomized feasibility study of docetaxel versus vinorelbine in advanced breast cancer.
The oncologist 2012;17(11):1429-e47.
2011: Mitch Dowsett; Matthew Ellis; Daniel F Hayes; N Lynn Henry; Judith C Hugh; Tracy Lively; Lisa McShane; Torsten O Nielsen; Soon Paik; Frederique Penault-Llorca; Ljudmila Prudkin; Meredith Regan; Janine Salter; Ian E Smith; Christos Sotiriou; Giuseppe Viale; Jo Anne Zujewski; Roger A'Hern; John Bartlett; R Charles Coombes; Jack Cuzick
Assessment of Ki67 in breast cancer: recommendations from the International Ki67 in Breast Cancer working group.
Journal of the National Cancer Institute 2011;103(22):1656-64.
2011: Gordon Mallarkey; R Charles Coombes
Advancing breast cancer therapy by translational research: highlights of the Improving Care and Knowledge through Translational Research (IMPAKT) breast cancer conference.
Therapeutic advances in medical oncology 2011;3(5):223-7.
2011: Yoshiya Horimoto; R Charles Coombes; Mona El-Bahrawy; Johan Hartman; Ka-Kei Ho; Sari I Mäkelä; Julie Millour; Yolanda Olmos; Steven Pollock; Matti Poutanen; Valerie Speirs; Eric W-F Lam
ERβ1 represses FOXM1 expression through targeting ERα to control cell proliferation in breast cancer.
The American journal of pathology 2011;179(3):1148-56.
2011: Justin Stebbing; Veena Surendrakumar; Richard Szydlo; Arun Thiyagarajan; R Charles Coombes; Jonathan Krell; Jacqueline S Lewis; Rachel Payne; David Peston; Sami Shousha
Epidermal growth factor receptor status in early stage breast cancer is associated with cellular proliferation but not cross-talk.
Journal of clinical pathology 2011;64(9):829-31.
2011: Donald A Berry; Marco Bregni; Jean Caputo; R Charles Coombes; John P Crown; Elisabeth G E de Vries; William E Barlow; Russell L Basser; Jonas Bergh; ALESSANDRO MASSIMO GIANNI; Gabriel N Hortobagyi; Marcella M Johnson; Xiudong Lei; Robert C Leonard; Ulrike A Nitz; Paolo Pedrazzoli; William P Peters; Henri Roché; Sjoerd Rodenhuis; Martin S Tallman; Yutaka Tokuda; Naoto T Ueno; Axel R Zander; Taner Demirer
High-dose chemotherapy with autologous stem-cell support as adjuvant therapy in breast cancer: overview of 15 randomized trials.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(24):3214-23.
2011: R Charles Coombes; Derek Cooper; Marinus O den Boer; Frans Erdkamp; Marc Espie; Judith M Bliss; Robert E Coleman; Lucy S Kilburn; Michel Marty; Justine A Reise; Marina W K Thomas; Alejandro Tres; Nicole Tubiana-Mathieu; Jacob Wals; Andrew Wardley; Katie Wilkinson; Pierre Hupperets
Randomized, phase III trial of sequential epirubicin and docetaxel versus epirubicin alone in postmenopausal patients with node-positive breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(24):3247-54.
2011: Bhavesh H Patel; Hetal Patel; Simak Ali; R Charles Coombes; Andrew M Mason; Anthony G M Barrett
Conversion of α-amino acids into bioactive o-aminoalkyl resorcylates and related dihydroxyisoindolinones.
The Journal of organic chemistry 2011;76(15):6209-17.
2011: Georgios Giamas; Andrew R Green; Jimmy Jacob; Heinz-Josef Lenz; Walter Messier; Andrew Photiou; Belul Assefa Shifa; Simak Ali; Leandro Castellano; R Charles Coombes; Ian O Ellis; Aleksandra Filipović; Cathy Tralau-Stewart; Dongyun Yang; Hua Zhang; Wu Zhang; Justin Stebbing
Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer.
Nature medicine 2011;17(6):715-9.
2011: Paul T R Thiruchelvam; Chun-Fui Lai; Hui Hua; Ross S Thomas; Antoni Hurtado; William Hudson; Andrew R Bayly; Fiona J Kyle; Manikandan Periyasamy; Andrew Photiou; Alan C Spivey; Eric ORTLUND; Richard J Whitby; Jason S Carroll; R Charles Coombes; Lakjaya Buluwela; Simak Ali
The liver receptor homolog-1 regulates estrogen receptor expression in breast cancer cells.
Breast cancer research and treatment 2011;127(2):385-96.
2011: K Page; N Hava; B Ward; J Brown; D S Guttery; C Ruangpratheep; K Blighe; A Sharma; Rosemary A Walker; R Charles Coombes; Jacqueline A Shaw
Detection of HER2 amplification in circulating free DNA in patients with breast cancer.
British journal of cancer 2011;104(8):1342-8.
2011: Carlo Palmieri; Deep Shah; Jonathan Krell; Ondrej Gojis; Katy Hogben; Pippa Riddle; Riz Ahmad; Tri Tat; Kevin Fox; Andrew Porter; Sarah Mahmoud; Stephanie Kirschke; Sami Shousha; Mihir Gudi; R Charles Coombes; Robert Leonard; Susan Cleator
Management and outcome of HER2-positive early breast cancer treated with or without trastuzumab in the adjuvant trastuzumab era.
Clinical breast cancer 2011;11(2):93-102.
2011: Carlo Palmieri; Adam Januszewski; Susie Stanway; R Charles Coombes
Irosustat: a first-generation steroid sulfatase inhibitor in breast cancer.
Expert review of anticancer therapy 2011;11(2):179-83.
2011: Jacqui A Shaw; James Brown; R Charles Coombes; Jimmy Jacob; Rachel Payne; Belinda Lee; Karen Page; Natasha Hava; Justin Stebbing
Circulating tumor cells and plasma DNA analysis in patients with indeterminate early or metastatic breast cancer.
Biomarkers in medicine 2011;5(1):87-91.
2011: R Charles Coombes; Lucy S Kilburn
Time to TEAM: exemestane, or tamoxifen then exemestane?
Lancet 2011;377(9762):280-1.
2011: Gordon Mallarkey; R Charles Coombes
Latest advances in medical oncology: highlights from Milan ESMO 2010 annual congress.
Therapeutic advances in medical oncology 2011;3(1):3-9.
2011: Simak Ali; Laki Buluwela; R Charles Coombes
Antiestrogens and their therapeutic applications in breast cancer and other diseases.
Annual review of medicine 2011;62():217-32.
2011: Aleksandra Filipović; Julian Hendrik Gronau; Andrew Green; Jayson Wang; Sabari Vallath; Dongmin Shao; Sabeena Rasul; Ian O Ellis; Ernesto Yagüe; Justin Sturge; R Charles Coombes
Biological and clinical implications of nicastrin expression in invasive breast cancer.
Breast cancer research and treatment 2011;125(1):43-53.
2010: Dean A Heathcote; Hetal Patel; Sebastian H B Kroll; Pascale Hazel; Manikandan Periyasamy; Mary Alikian; Seshu K Kanneganti; Ashutosh S Jogalekar; Bodo Scheiper; Marion Barbazanges; Andreas Blum; Jan Brackow; Alekasandra Siwicka; Robert D M Pace; Matthew J Fuchter; James P Snyder; Dennis C Liotta; Paul S Freemont; Eric O Aboagye; R Charles Coombes; Anthony G M Barrett; Simak Ali
A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.
Journal of medicinal chemistry 2010;53(24):8508-22.
2010: R Charles Coombes; Gordon Mallarkey
Latest therapeutic advances from the ASCO 2010 Annual Meeting.
Therapeutic advances in medical oncology 2010;2(6):347-50.
2010: Robert E Coleman; Linda M Banks; Samia I Girgis; Eduard Vrdoljak; John Fox; Simon J Cawthorn; Ashraf Patel; Judith M Bliss; R Charles Coombes; Lucy S Kilburn
Reversal of skeletal effects of endocrine treatments in the Intergroup Exemestane Study.
Breast cancer research and treatment 2010;124(1):153-61.
2010: Laura Kenny; Kaiyumars B Contractor; Rainer Hinz; Justin Stebbing; Carlo Palmieri; Jie Jiang; Sami Shousha; Adil Al-Nahhas; R Charles Coombes; Eric O Aboagye
Reproducibility of [11C]choline-positron emission tomography and effect of trastuzumab.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(16):4236-45.
2010: Marion Procter; Thomas M Suter; Evandro de Azambuja; Urania Dafni; Veerle van Dooren; Susanne Muehlbauer; Miguel Angel Climent; Ernst Rechberger; Walter Tsang-Wu Liu; Mazakasu Toi; R Charles Coombes; David Dodwell; Olivia Pagani; Jorge Madrid; Marcia Hall; Shin-Cheh Chen; Christian Focan; Michael Muschol; Dirk J van Veldhuisen; Martine J Piccart-Gebhart
Longer-term assessment of trastuzumab-related cardiac adverse events in the Herceptin Adjuvant (HERA) trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(21):3422-8.
2010: J Millour; D Constantinidou; Alexandra V Stavropoulou; M S C Wilson; S S Myatt; J M-M Kwok; K Sivanandan; R Charles Coombes; R H Medema; J Hartman; A E Lykkesfeldt; Eric W-F Lam
FOXM1 is a transcriptional target of ERalpha and has a critical role in breast cancer endocrine sensitivity and resistance.
Oncogene 2010;29(20):2983-95.
2010: Barrie Peck; Chun-Yuan Chen; Ka-Kei Ho; Paolo Di Fruscia; Stephen S Myatt; R Charles Coombes; Matthew J Fuchter; Chwan-Deng Hsiao; Eric W-F Lam
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.
Molecular cancer therapeutics 2010;9(4):844-55.
2010: Katherine R Gray; Kaiyumars B Contractor; Laura Kenny; Adil Al-Nahhas; Sami Shousha; Justin Stebbing; Harpreet S Wasan; R Charles Coombes; Eric O Aboagye; Federico E Turkheimer; Lula Rosso
Kinetic filtering of [(18)F]Fluorothymidine in positron emission tomography studies.
Physics in medicine and biology 2010;55(3):695-709.
2010: Jimmy M-M Kwok; Barrie Peck; Lara J Monteiro; Helma D C Schwenen; Julie Millour; R Charles Coombes; Stephen S Myatt; Eric W-F Lam
FOXM1 confers acquired cisplatin resistance in breast cancer cells.
Molecular cancer research : MCR 2010;8(1):24-34.
2009: Long R Jiao; Christos Apostolopoulos; Jimmy Jacob; Richard Szydlo; Natalia Johnson; Nicole Tsim; Nagy A Habib; R Charles Coombes; Justin Stebbing
Unique localization of circulating tumor cells in patients with hepatic metastases.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(36):6160-5.
2009: Hector C Keun; Jasmin Sidhu; Dmitry Pchejetski; Jacqueline S Lewis; Helena Marconell; Michael Patterson; Steven R Bloom; Vian Amber; R Charles Coombes; Justin Stebbing
Serum molecular signatures of weight change during early breast cancer chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(21):6716-23.
2009: Laura Kenny; Kaiyumars B Contractor; Justin Stebbing; Adil Al-Nahhas; Carlo Palmieri; Sami Shousha; R Charles Coombes; Eric O Aboagye
Altered tissue 3'-deoxy-3'-[18F]fluorothymidine pharmacokinetics in human breast cancer following capecitabine treatment detected by positron emission tomography.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(21):6649-57.
2009: Leandro Castellano; Georgios Giamas; Jimmy Jacob; R Charles Coombes; Walter Lucchesi; Paul Thiruchelvam; Geraint Barton; Long R Jiao; Robin Wait; Jonathan Waxman; Gregory J Hannon; Justin Stebbing
The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(37):15732-7.
2009: Kaiyumars B Contractor; Laura Kenny; Justin Stebbing; Adil Al-Nahhas; Carlo Palmieri; Dudley Sinnett; Jacqueline S Lewis; Katy Hogben; Safiye Osman; Sami Shousha; C Lowdell; R Charles Coombes; Eric O Aboagye
[11C]choline positron emission tomography in estrogen receptor-positive breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(17):5503-10.
2009: Simak Ali; Dean A Heathcote; Sebastian H B Kroll; Ashutosh S Jogalekar; Bodo Scheiper; Hetal Patel; Jan Brackow; Alekasandra Siwicka; Matthew J Fuchter; Manikandan Periyasamy; Robert S Tolhurst; Seshu K Kanneganti; James P Snyder; Dennis C Liotta; Eric O Aboagye; Anthony G M Barrett; R Charles Coombes
The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity.
Cancer research 2009;69(15):6208-15.
2009: Mark Tuthill; Robert Pell; Rosa Guiliani; Adrian Lim; Mihir Gudi; Kaiyumars B Contractor; Jacqueline S Lewis; R Charles Coombes; Justin Stebbing
Peritoneal disease in breast cancer: a specific entity with an extremely poor prognosis.
European journal of cancer (Oxford, England : 1990) 2009;45(12):2146-9.
2009: R Charles Coombes
Editorial.
Therapeutic advances in medical oncology 2009;1(1):3.
2009: Richard E Francis; Stephen S Myatt; Janna Krol; Johan Hartman; Barrie Peck; Ursula B McGovern; Jun Wang; Stephanie K Guest; Aleksandra Filipovic; Ondrej Gojis; Carlo Palmieri; David Peston; Sami Shousha; Qunyan Yu; Piotr Sicinski; R Charles Coombes; Eric W-F Lam
FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer.
International journal of oncology 2009;35(1):57-68.
2009: S Rasul; R Balasubramanian; A Filipović; Martin J Slade; E Yagüe; R Charles Coombes
Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells.
British journal of cancer 2009;100(12):1879-88.
2009: Susan J Cleator; Eliyaz Ahamed; R Charles Coombes; Carlo Palmieri
A 2009 update on the treatment of patients with hormone receptor-positive breast cancer.
Clinical breast cancer 2009;9 Suppl 1():S6-S17.
2009: Belinda Lee; Ingrid Franklin; Jacqueline S Lewis; R Charles Coombes; Robert Leonard; Philip Gishen; Justin Stebbing
The efficacy of percutaneous vertebroplasty for vertebral metastases associated with solid malignancies.
European journal of cancer (Oxford, England : 1990) 2009;45(9):1597-602.
2009: Georgios Giamas; Leandro Castellano; Qin Feng; Uwe Knippschild; Jimmy Jacob; Ross S Thomas; R Charles Coombes; Carolyn L Smith; Long R Jiao; Justin Stebbing
CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions.
Nucleic acids research 2009;37(9):3110-23.
2009: Ursula B McGovern; Richard E Francis; Barrie Peck; Stephanie K Guest; Jun Wang; Stephen S Myatt; Janna Krol; Jimmy M-M Kwok; Andreas Polychronis; R Charles Coombes; Eric W-F Lam
Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer.
Molecular cancer therapeutics 2009;8(3):582-91.
2009: Martin J Slade; R Payne; S Riethdorf; B Ward; S A A Zaidi; Justin Stebbing; Carlo Palmieri; H Dudley Sinnett; Elena Kulinskaya; TIM PITFIELD; R T McCormack; K Pantel; R Charles Coombes
Comparison of bone marrow, disseminated tumour cells and blood-circulating tumour cells in breast cancer patients after primary treatment.
British journal of cancer 2009;100(1):160-6.
2009: Rachel E Payne; Ernesto Yagüe; Martin J Slade; Christos Apostolopoulos; Long R Jiao; Becky Ward; R Charles Coombes; Justin Stebbing
Measurements of EGFR expression on circulating tumor cells are reproducible over time in metastatic breast cancer patients.
Pharmacogenomics 2009;10(1):51-7.
2008: Paul J Mintz; Nagy A Habib; Louise J Jones; Georgios Giamas; Jacqueline S Lewis; Rebecca L Bowen; R Charles Coombes; Justin Stebbing
The phosphorylated membrane estrogen receptor and cytoplasmic signaling and apoptosis proteins in human breast cancer.
Cancer 2008;113(6):1489-95.
2008: Carlo Palmieri; R Charles Coombes; Sung-Bae Kim; Suzy Cleator
Ethnicity and breast cancer research.
Lancet 2008;372(9634):188-9.
2008: Jimmy M-M Kwok; Stephen S Myatt; Charles M Marson; R Charles Coombes; Demetra Constantinidou; Eric W-F Lam
Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression.
Molecular cancer therapeutics 2008;7(7):2022-32.
2008: Laura Kenny; R Charles Coombes; Inger Oulie; Kaiyumars B Contractor; Matthew Miller; Terence J Spinks; Brian McParland; Pamela S Cohen; Ai-Min Hui; Carlo Palmieri; Safiye Osman; Matthias Glaser; David Turton; Adil Al-Nahhas; Eric O Aboagye
Phase I trial of the positron-emitting Arg-Gly-Asp (RGD) peptide radioligand 18F-AH111585 in breast cancer patients.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(6):879-86.
2008: Ross S Thomas; Naveed Sarwar; Fladia Phoenix; R Charles Coombes; Simak Ali
Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-alpha activity.
Journal of molecular endocrinology 2008;40(4):173-84.
2008: Aman U Buzdar; R Charles Coombes; Paul E Goss; Eric P Winer
Summary of aromatase inhibitor clinical trials in postmenopausal women with early breast cancer.
Cancer 2008;112(3 Suppl):700-9.
2008: Steven E Come; Aman U Buzdar; James N Ingle; Stephen R D Johnston; Angela Brodie; R Charles Coombes; William R Miller; Kathleen I Pritchard; Eric P Winer; Jo Anne Zujewski; Paul E Goss
Endocrine and targeted manipulation of breast cancer: summary statement for the Sixth Cambridge Conference.
Cancer 2008;112(3 Suppl):673-8.
2008: Martina Baur; Allan T van Oosterom; Véronique Diéras; Michèle Tubiana-Hulin; R Charles Coombes; Thomas Hatschek; Michael Murawsky; May Klink-Alakl; Marcus Hudec; Christian Dittrich
A phase II trial of docetaxel (Taxotere) as second-line chemotherapy in patients with metastatic breast cancer.
Journal of cancer research and clinical oncology 2008;134(2):125-35.
2007: Janna Krol; Richard E Francis; André Albergaria; Andrew Sunters; Andreas Polychronis; R Charles Coombes; Eric W-F Lam
The transcription factor FOXO3a is a crucial cellular target of gefitinib (Iressa) in breast cancer cells.
Molecular cancer therapeutics 2007;6(12 Pt 1):3169-79.
2007: Jie Jiang; Naveed Sarwar; David Peston; Elena Kulinskaya; Sami Shousha; R Charles Coombes; Simak Ali
Phosphorylation of estrogen receptor-alpha at Ser167 is indicative of longer disease-free and overall survival in breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5769-76.
2007: Laura Kenny; R Charles Coombes; David M Vigushin; Adil Al-Nahhas; Sami Shousha; Eric O Aboagye
Imaging early changes in proliferation at 1 week post chemotherapy: a pilot study in breast cancer patients with 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography.
European journal of nuclear medicine and molecular imaging 2007;34(9):1339-47.
2007: Susan Cleator; Wolfgang Heller; R Charles Coombes
Triple-negative breast cancer: therapeutic options.
The lancet oncology 2007;8(3):235-44.
2007: Robert E Coleman; Linda M Banks; Samia I Girgis; Lucy S Kilburn; Eduard Vrdoljak; John Fox; Simon J Cawthorn; Ashraf Patel; Claire F Snowdon; Emma Hall; Judith M Bliss; R Charles Coombes
Skeletal effects of exemestane on bone-mineral density, bone biomarkers, and fracture incidence in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES): a randomised controlled study.
The lancet oncology 2007;8(2):119-27.
2007: Martin J Slade; R Charles Coombes
The clinical significance of disseminated tumor cells in breast cancer.
Nature clinical practice. Oncology 2007;4(1):30-41.
2007: W Heller; Danish Mazhar; R Ward; H Dudley Sinnett; C Lowdell; R Phillips; Sami Shousha; A Fayaz; Carlo Palmieri; R Charles Coombes
Neoadjuvant 5-fluorouracil, epirubicin and cyclophosphamide chemotherapy followed by docetaxel in refractory patients with locally advanced breast cancer.
Oncology reports 2007;17(1):253-9.
2006: Jennifer C Hu; Matthew J Booth; Gopichand Tripuraneni; Derek Davies; Syed A A Zaidi; Manuela Tamburo de Bella; Martin J Slade; Stephen B Marley; Myrtle Y A Gordon; Robert S Coffin; R Charles Coombes; Tahereh Kamalati
A novel HSV-1 virus, JS1/34.5-/47-, purges contaminating breast cancer cells from bone marrow.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(22):6853-62.
2006: Jennifer C C Hu; Robert S Coffin; Ceri J Davis; Nicola J Graham; Natasha Groves; Peter J Guest; Kevin J Harrington; Nicholas James; Colin A Love; Iain McNeish; Louise C Medley; Agnieszka Michael; christopher nutting; Hardev Pandha; Claire A Shorrock; Julie Simpson; Jan Steiner; Neil M Steven; Dennis Wright; R Charles Coombes
A phase I study of OncoVEXGM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(22):6737-47.
2006: Karen Page; Tom Powles; Martin J Slade; Manuela Tamburo De Bella; Rosemary A Walker; R Charles Coombes; Jacqueline A Shaw
The importance of careful blood processing in isolation of cell-free DNA.
Annals of the New York Academy of Sciences 2006;1075():313-7.
2006: Naveed Sarwar; J-S Kim; J Jiang; David Peston; H Dudley Sinnett; P Madden; J M Gee; R I Nicholson; A E Lykkesfeldt; S Shousha; R Charles Coombes; Simak Ali
Phosphorylation of ERalpha at serine 118 in primary breast cancer and in tamoxifen-resistant tumours is indicative of a complex role for ERalpha phosphorylation in breast cancer progression.
Endocrine-related cancer 2006;13(3):851-61.
2006: Patricia A Madureira; Rana Varshochi; Demetra Constantinidou; Richard E Francis; R Charles Coombes; Kwok-Ming Yao; Eric W-F Lam
The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells.
The Journal of biological chemistry 2006;281(35):25167-76.
2006: Susannah J Stanway; Atul Purohit; L W Lawrence Woo; Saulat Sufi; David M Vigushin; Rebecca Ward; Richard H Wilson; Frank Z Stanczyk; Nicola Dobbs; Elena Kulinskaya; Moira Elliott; Barry V L Potter; Michael J Reed; R Charles Coombes
Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(5):1585-92.
2006: H T Ford; R Charles Coombes; JC Gazet; R Gray; C C McConkey; R Sutcliffe; J Quilliam; S Lowndes
Long-term follow-up of a randomised trial designed to determine the need for irradiation following conservative surgery for the treatment of invasive breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(3):401-8.
2006: Lesley Fallowfield; Judith M Bliss; Lucy S Porter; Miranda H Price; Claire F Snowdon; Stephen E Jones; R Charles Coombes; Emma Hall
Quality of life in the intergroup exemestane study: a randomized trial of exemestane versus continued tamoxifen after 2 to 3 years of tamoxifen in postmenopausal women with primary breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(6):910-7.
2006: D Nitti; Jacques A Wils; J Guimaraes Dos Santos; G Fountzilas; P F Conte; C Sava; A Tres; R Charles Coombes; D Crivellari; Alberto Marchet; E Sanchez; Judith M Bliss; Janis Homewood; ML Couvreur; E Hall; Benoît Baron; E Woods; M Emson; E Van Cutsem; Mario Lise
Randomized phase III trials of adjuvant FAMTX or FEMTX compared with surgery alone in resected gastric cancer. A combined analysis of the EORTC GI Group and the ICCG.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(2):262-9.
2006: John P Alao; Alexandra V Stavropoulou; Eric W-F Lam; R Charles Coombes
Role of glycogen synthase kinase 3 beta (GSK3beta) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells.
Molecular cancer 2006;5():40.
2006: John P Alao; Alexandra V Stavropoulou; Eric W-F Lam; R Charles Coombes; David M Vigushin
Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells.
Molecular cancer 2006;5():8.
2006: John P Alao; Simon C Gamble; Alexandra V Stavropoulou; Karen M Pomeranz; Eric W-F Lam; R Charles Coombes; David M Vigushin
The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines.
Molecular cancer 2006;5():7.
2006: Andrew Sunters; Patricia A Madureira; Karen M Pomeranz; Muriel Aubert; Jan J Brosens; Simon J Cook; Boudewijn M T Burgering; R Charles Coombes; Eric W-F Lam
Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt.
Cancer research 2006;66(1):212-20.
2006: Roopinder Gillmore; Shao-An Xue; shao-an xue; Jaspal Kaeda; Dimitri Hadjiminas; Vourneen Healy; Roberto Dina; Suzanne C Parry; Ilaria Bellantuono; Yasmeen Ghani; R Charles Coombes; Jonathan Waxman; Hans J Stauss
Detection of Wilms' tumor antigen--specific CTL in tumor-draining lymph nodes of patients with early breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(1):34-42.
2005: Selina Raguz; Manuela Tamburo De Bella; Martin J Slade; Christopher F Higgins; R Charles Coombes; Ernesto Yagüe
Expression of RPIP9 (Rap2 interacting protein 9) is activated in breast carcinoma and correlates with a poor prognosis.
International journal of cancer. Journal international du cancer 2005;117(6):934-41.
2005: Laura Kenny; David M Vigushin; Adil Al-Nahhas; Safiye Osman; Sajinder K Luthra; Sami Shousha; R Charles Coombes; Eric O Aboagye
Quantification of cellular proliferation in tumor and normal tissues of patients with breast cancer by [18F]fluorothymidine-positron emission tomography imaging: evaluation of analytical methods.
Cancer research 2005;65(21):10104-12.
2005: Ashita Waterston; Lindsey Gumbrell; T Bratt; S Waller; J Gustav-Aspland; C L'hermenier; K Bellenger; M Campbell; T Powles; M Highley; mark bower; Søren Mouritsen; M Feldmann; R Charles Coombes
Phase I study of TNFalpha AutoVaccIne in patients with metastatic cancer.
Cancer immunology, immunotherapy : CII 2005;54(9):848-57.
2005: Stephan Braun; Florian D Vogl; Bjørn Naume; Wolfgang Janni; Michael P Osborne; R Charles Coombes; Günter Schlimok; Ingo J Diel; Bernd Gerber; Gerhard Gebauer; Jean-Yves Pierga; Christian Marth; Daniel Oruzio; Gro Wiedswang; Erich Solomayer; Günther Kundt; Barbara Strobl; Tanja Fehm; George Y C Wong; Judith Bliss; Anne Vincent-Salomon; Klaus Pantel
A pooled analysis of bone marrow micrometastasis in breast cancer.
The New England journal of medicine 2005;353(8):793-802.
2005: Scott P Fraser; James Diss; Athina-Myrto CHIONI; Maria E Mycielska; Huiyan Pan; Rezan F Yamaci; Filippo Pani; Zuzanna S Siwy; Monika Krasowska; Zbigniew J Grzywna; William J Brackenbury; Dimis Theodorou; Meral Koyutürk; Handan Kaya; Esra Battaloglu; Manuela Tamburo De Bella; Martin J Slade; Robert Tolhurst; Carlo Palmieri; Jie Jiang; David S Latchman; R Charles Coombes; Mustafa B A Djamgoz
Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(15):5381-9.
2005: Claudio Praga; Jonas Bergh; Judith Bliss; Jacques Bonneterre; Bruno Cesana; R Charles Coombes; Pierre Fargeot; Annika Folin; Pierre Fumoleau; Rosa Giuliani; Pierre Kerbrat; Michel Hery; Jonas Nilsson; Francesco Onida; Martine Piccart; Lois Shepherd; Patrick Therasse; Jacques Wils; David Rogers
Risk of acute myeloid leukemia and myelodysplastic syndrome in trials of adjuvant epirubicin for early breast cancer: correlation with doses of epirubicin and cyclophosphamide.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(18):4179-91.
2005: Andreas Polychronis; H Dudley Sinnett; Dimitri Hadjiminas; Hemant Singhal; Janine L Mansi; Dharsha Shivapatham; Sami Shousha; Jie Jiang; David Peston; Nigel Barrett; David M Vigushin; Ken Morrison; Emma Beresford; Simak Ali; Martin J Slade; R Charles Coombes
Preoperative gefitinib versus gefitinib and anastrozole in postmenopausal patients with oestrogen-receptor positive and epidermal-growth-factor-receptor-positive primary breast cancer: a double-blind placebo-controlled phase II randomised trial.
The lancet oncology 2005;6(6):383-91.
2005: R Charles Coombes; Judith M Bliss; Emma Hall
Safety of exemestane in the Intergroup Exemestane Study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(13):3171-2.
2005: R Charles Coombes; A Howell; M Emson; Clare Peckitt; C Gallagher; C Bengala; A Tres; R Welch; P Lawton; R Rubens; E Woods; Jo Haviland; D Vigushin; E Kanfer; Judith M Bliss
High dose chemotherapy and autologous stem cell transplantation as adjuvant therapy for primary breast cancer patients with four or more lymph nodes involved: long-term results of an international randomised trial.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2005;16(5):726-34.
2005: Martin J Slade; Anjana Singh; Brendan M Smith; Gopi Tripuraneni; Emma Hall; Clare Peckitt; Samantha Fox; Helen Graham; Margreet Lüchtenborg; H Dudley Sinnett; Nicholas C P Cross; R Charles Coombes
Persistence of bone marrow micrometastases in patients receiving adjuvant therapy for breast cancer: results at 4 years.
International journal of cancer. Journal international du cancer 2005;114(1):94-100.
2005: Lakjaya Buluwela; Joanna Pike; Danish Mazhar; Tahereh Kamalati; Stephen M Hart; Rajai Al-Jehani; H Yahaya; N Patel; Naveed Sarwar; N Sarwarl; D A Heathcote; O Schwickerath; Fladia Phoenix; R Hill; Eric O Aboagye; Sami Shousha; Jonathan Waxman; Nick Lemoine; Arthur Zelent; R Charles Coombes; Simak Ali
Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-alpha and the transcriptional repressor PLZF.
Gene therapy 2005;12(5):452-60.
2005: Rana Varshochi; Faezah Halim; Andrew Sunters; John P Alao; Patricia A Madureira; Stephen M Hart; Simak Ali; David M Vigushin; R Charles Coombes; Eric W-F Lam
ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line.
The Journal of biological chemistry 2005;280(5):3185-96.
2005: Carlo Palmieri; R Charles Coombes; David M Vigushin
Targeted histone deacetylase inhibition for cancer prevention and therapy.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 2005;63():147-81.
2004: John P Alao; Eric W-F Lam; Simak Ali; Lakjaya Buluwela; Walter Bordogna; Peter M Lockey; Rana Varshochi; Alexandra V Stavropoulou; R Charles Coombes; David M Vigushin
Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(23):8094-104.
2004: L Sanderson; G W Taylor; Eric O Aboagye; John P Alao; John R Latigo; R Charles Coombes; David M Vigushin
Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(10):1132-8.
2004: Carlo Palmieri; S Saji; H Sakaguchi; G Cheng; Andrew Sunters; M J O'Hare; Margaret Warner; Jan-�ke GUSTAFSSON; R Charles Coombes; Eric W-F Lam
The expression of oestrogen receptor (ER)-beta and its variants, but not ERalpha, in adult human mammary fibroblasts.
Journal of molecular endocrinology 2004;33(1):35-50.
2004: Nicola M Neary; Caroline J Small; Alison M Wren; Jennifer L Lee; Maralyn R Druce; Carlo Palmieri; Gary S Frost; Mohammad A Ghatei; R Charles Coombes; Stephen R Bloom
Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial.
The Journal of clinical endocrinology and metabolism 2004;89(6):2832-6.
2004: Carlo Palmieri; David M Vigushin; R Charles Coombes
Stem-cell therapy for myocardial diseases.
Lancet 2004;363(9422):1734-5; author reply 1735.
2004: Charles M Marson; Nawal Serradji; Alphonso S Rioja; Sebastien P Gastaud; John P Alao; R Charles Coombes; David M Vigushin
Stereodefined and polyunsaturated inhibitors of histone deacetylase based on (2E,4E)-5-arylpenta-2,4-dienoic acid hydroxyamides.
Bioorganic & medicinal chemistry letters 2004;14(10):2477-81.
2004: Carlo Palmieri; Eric W-F Lam; David M Vigushin; R Charles Coombes
Value of SERMs in postmenopausal women.
Lancet 2004;363(9419):1477-8.
2004: Selina Raguz; Manuela Tamburo De Bella; Gopichani Tripuraneni; Martin J Slade; Christopher F Higgins; R Charles Coombes; Ernesto Yagüe
Activation of the MDR1 upstream promoter in breast carcinoma as a surrogate for metastatic invasion.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(8):2776-83.
2004: Carlo Palmieri; Eric W-F Lam; Janine Mansi; Claire MacDonald; Sami Shousha; Peter Madden; Yoko Omoto; Andrew Sunters; Margaret Warner; Jan-�ke GUSTAFSSON; R Charles Coombes
The expression of ER beta cx in human breast cancer and the relationship to endocrine therapy and survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(7):2421-8.
2004: Stephen R D Johnston; Lindsey Gumbrell; T R J Evans; R E Coleman; IE Smith; C J Twelves; M Soukop; D W Rea; Helena Earl; A Howell; A Jones; PA Canney; T J Powles; BP Haynes; Bernard P Nutley; RM Grimshaw; Michael Jarman; Gavin Halbert; M Brampton; J Haviland; Mitch Dowsett; R Charles Coombes
A cancer research (UK) randomized phase II study of idoxifene in patients with locally advanced/metastatic breast cancer resistant to tamoxifen.
Cancer chemotherapy and pharmacology 2004;53(4):341-8.
2004: Ashita Waterston; F Salway; E Andreakos; DM Butler; M Feldmann; R Charles Coombes
TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model.
British journal of cancer 2004;90(6):1279-84.
2004: R Charles Coombes; Emma Hall; Lorna J Gibson; Robert Paridaens; Jacek Jassem; Thierry Delozier; Stephen E Jones; Isabel Alvarez; Gianfilippo Bertelli; Olaf Ortmann; Alan Coates; Emilio Bajetta; David Dodwell; Robert E Coleman; Lesley Fallowfield; Elizabeth Mickiewicz; Jorn Andersen; Per Eystein Lønning; Giorgio Cocconi; Alan Stewart; Nick Stuart; Claire F Snowdon; Marina Carpentieri; Giorgio Massimini; Judith M Bliss; Cornelius van de Velde
A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer.
The New England journal of medicine 2004;350(11):1081-92.
2004: David M Vigushin; Y Dong; L Inman; N Peyvandi; John P Alao; C Sun; Simak Ali; Eric J Niesor; Craig L Bentzen; R Charles Coombes
The nuclear oxysterol receptor LXRalpha is expressed in the normal human breast and in breast cancer.
Medical oncology (Northwood, London, England) 2004;21(2):123-31.
2004: David M Vigushin; N Mirsaidi; Greg Brooke; C Sun; P Pace; L Inman; Christopher J Moody; R Charles Coombes
Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo.
Medical oncology (Northwood, London, England) 2004;21(1):21-30.
2003: Andrew Sunters; Silvia Fernández de Mattos; Marie Stahl; Jan J Brosens; Georgia Zoumpoulidou; Catherine A Saunders; Paul J Coffer; René H Medema; R Charles Coombes; Eric W-F Lam
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines.
The Journal of biological chemistry 2003;278(50):49795-805.
2003: Anjana Singh; Simak Ali; Manish S Kothari; Manuela Tamburo De Bella; Clive Smith; Emma Timms; Martin J Slade; Brian M Foxwell; R Charles Coombes
Reporter gene assay demonstrates functional differences in estrogen receptor activity in purified breast cancer cells: a pilot study.
International journal of cancer. Journal international du cancer 2003;107(5):700-6.
2003: David M Vigushin; Greg Brooke; David Willows; R Charles Coombes; Christopher J Moody
Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I.
Bioorganic & medicinal chemistry letters 2003;13(21):3661-3.
2003: Chunyan Zhao; Eric W-F Lam; Andrew Sunters; Eva Enmark; Manuela Tamburo De Bella; R Charles Coombes; Jan-�ke GUSTAFSSON; Karin Dahlman-Wright
Expression of estrogen receptor beta isoforms in normal breast epithelial cells and breast cancer: regulation by methylation.
Oncogene 2003;22(48):7600-6.
2003: Dongsheng Chen; Marie J Lucey; Fladia Phoenix; Jorge Lopez-Garcia; Stephen M Hart; Régine Losson; Lakjaya Buluwela; R Charles Coombes; Pierre Chambon; Primo Schär; Simak Ali
T:G mismatch-specific thymine-DNA glycosylase potentiates transcription of estrogen-regulated genes through direct interaction with estrogen receptor alpha.
The Journal of biological chemistry 2003;278(40):38586-92.
2003: Carlo Palmieri; Roopinder Gillmore; A Menzies-Gow; S Fishpool; D Robinson; R Shaw; R Charles Coombes
Resolution of late-onset asthma following high-dose chemotherapy.
Bone marrow transplantation 2003;32(8):847-8.
2003: R Charles Coombes; L Gibson; E Hall; M Emson; Judith M Bliss
Aromatase inhibitors as adjuvant therapies in patients with breast cancer.
The Journal of steroid biochemistry and molecular biology 2003;86(3-5):309-11.
2003: M S Kothari; Simak Ali; Lakjaya Buluwela; Naomi Livni; Sami Shousha; H Dudley Sinnett; R Vashisht; P Thorpe; Susan Van Noorden; R Charles Coombes; Martin J Slade
Purified malignant mammary epithelial cells maintain hormone responsiveness in culture.
British journal of cancer 2003;88(7):1071-6.
2003: Carlo Palmieri; D Roberts-Clark; A Assadi-Sabet; RC Coope; M O'Hare; Andrew Sunters; A Hanby; Martin J Slade; jennifer gomm; Eric W-F Lam; R Charles Coombes
Fibroblast growth factor 7, secreted by breast fibroblasts, is an interleukin-1beta-induced paracrine growth factor for human breast cells.
The Journal of endocrinology 2003;177(1):65-81.
2002: Dongsheng Chen; Elinor Washbrook; Naveed Sarwar; Gaynor J Bates; Paul E Pace; Vatsala Thirunuvakkarasu; Jacqueline Taylor; Richard J Epstein; Frances V Fuller-Pace; Jean-Marc Egly; R Charles Coombes; Simak Ali
Phosphorylation of human estrogen receptor alpha at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera.
Oncogene 2002;21(32):4921-31.
2002: C Zammit; RC Coope; jennifer gomm; Sami Shousha; CL Johnston; R Charles Coombes
Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer.
British journal of cancer 2002;86(7):1097-103.
2002: Carlo Palmieri; G J Cheng; Shigetoyo Saji; M Zelada-Hedman; A Wärri; Weihua Zhang; Susan Van Noorden; T Wahlstrom; R Charles Coombes; Margaret Warner; Jan-�ke GUSTAFSSON
Estrogen receptor beta in breast cancer.
Endocrine-related cancer 2002;9(1):1-13.
2002: Simak Ali; R Charles Coombes
Endocrine-responsive breast cancer and strategies for combating resistance.
Nature reviews. Cancer 2002;2(2):101-12.
2002: Charles M Marson; Alphonso S Rioja; Greg Brooke; R Charles Coombes; David M Vigushin
Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase.
Bioorganic & medicinal chemistry letters 2002;12(2):255-9.
2002: David M Vigushin; R Charles Coombes
Histone deacetylase inhibitors in cancer treatment.
Anti-cancer drugs 2002;13(1):1-13.
2001: EV Jensen; Guojun Cheng; C Palmieri; Shigetoyo Saji; Sari Mäkelä; Susan Van Noorden; T Wahlström; Margaret Warner; R Charles Coombes; Jan-�ke GUSTAFSSON
Estrogen receptors and proliferation markers in primary and recurrent breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(26):15197-202.
2001: JC Gazet; H T Ford; R Gray; C McConkey; R Sutcliffe; J Quilliam; V Makinde; S Lowndes; R Charles Coombes
Estrogen-receptor-directed neoadjuvant therapy for breast cancer: results of a randomised trial using formestane and methotrexate, mitozantrone and mitomycin C (MMM) chemotherapy.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2001;12(5):685-91.
2001: S D Thomson; Simak Ali; L Pickles; J Taylor; PE Pace; M Lymboura; S Shousha; R Charles Coombes
Analysis of estrogen-responsive finger protein expression in benign and malignant human breast.
International journal of cancer. Journal international du cancer 2001;91(2):152-8.
2001: D Liu; Lakjaya Buluwela; Simak Ali; S Thomson; jennifer gomm; R Charles Coombes
Retroviral infection of the FGF2 gene into MCF-7 cells induces branching morphogenesis, retards cell growth and suppresses tumorigenicity in nude mice.
European journal of cancer (Oxford, England : 1990) 2001;37(2):268-80.
2000: Simak Ali; R Charles Coombes
Estrogen receptor alpha in human breast cancer: occurrence and significance.
Journal of mammary gland biology and neoplasia 2000;5(3):271-81.
2000: Brendan M Smith; Martin J Slade; J English; H Graham; Margreet Lüchtenborg; H Dudley Sinnett; Nicholas C P Cross; R Charles Coombes
Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(7):1432-9.
2000: Jacqueline A Shaw; Brendan M Smith; T Walsh; S Johnson; L Primrose; Martin J Slade; Rosemary A Walker; R Charles Coombes
Microsatellite alterations plasma DNA of primary breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):1119-24.
2000: D I Udom; David M Vigushin; H Linardou; H Graham; C Palmieri; R Charles Coombes
Two weekly vinorelbine: administration in patients who have received at least two prior chemotherapy regimes for advanced breast cancer.
European journal of cancer (Oxford, England : 1990) 2000;36(2):177-82.
1999: C Harper-Wynne; J English; L Meyer; mark bower; C Archer; H Dudley Sinnett; C Lowdell; R Charles Coombes
Randomized trial to compare the efficacy and toxicity of cyclophosphamide, methotrexate and 5-fluorouracil (CMF) with methotrexate mitoxantrone (MM) in advanced carcinoma of the breast.
British journal of cancer 1999;81(2):316-22.
1999: Janine L Mansi; H Gogas; Judith M Bliss; JC Gazet; U Berger; R Charles Coombes
Outcome of primary-breast-cancer patients with micrometastases: a long-term follow-up study.
Lancet 1999;354(9174):197-202.
1999: M J Donaldson; V Skoumas; M Watson; P A Ashworth; H Ryder; M Moore; R Charles Coombes
XR3054, structurally related to limonene, is a novel inhibitor of farnesyl protein transferase.
European journal of cancer (Oxford, England : 1990) 1999;35(6):1014-9.
1999: C Harper-Wynne; R Charles Coombes
Anastrozole shows evidence of activity in postmenopausal patients who have responded or stabilised on formestane therapy.
European journal of cancer (Oxford, England : 1990) 1999;35(5):744-6.
1999: Martin J Slade; Brendan M Smith; H Dudley Sinnett; Nicholas C P Cross; R Charles Coombes
Quantitative polymerase chain reaction for the detection of micrometastases in patients with breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(3):870-9.
1999: Martin J Slade; RC Coope; jennifer gomm; R Charles Coombes
The human mammary gland basement membrane is integral to the polarity of luminal epithelial cells.
Experimental cell research 1999;247(1):267-78.
1999: D Chen; PE Pace; R Charles Coombes; Simak Ali
Phosphorylation of human estrogen receptor alpha by protein kinase A regulates dimerization.
Molecular and cellular biology 1999;19(2):1002-15.
1999: S K Marsh; GS Bansal; C Zammit; R Barnard; RC Coope; D Roberts-Clarke; jennifer gomm; R Charles Coombes; CL Johnston
Increased expression of fibroblast growth factor 8 in human breast cancer.
Oncogene 1999;18(4):1053-60.
1998: J Taylor; M Lymboura; PE Pace; R P A'hern; A J Desai; S Shousha; R Charles Coombes; Simak Ali
An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers.
International journal of cancer. Journal international du cancer 1998;79(4):334-42.
1998: TJ Gulliford; J English; K W Colston; P Menday; S Moller; R Charles Coombes
A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer.
British journal of cancer 1998;78(1):6-13.
1998: C D Archer; C Lowdell; H Dudley Sinnett; J English; S Khan; R Charles Coombes
Docetaxel: response in patients who have received at least two prior chemotherapy regimens for metastatic breast cancer.
European journal of cancer (Oxford, England : 1990) 1998;34(6):816-9.
1998: R Charles Coombes
Aromatase inhibitors and their use in the adjuvant setting.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1998;152():277-84.
1998: David M Vigushin; G K Poon; A Boddy; J English; Gavin Halbert; C Pagonis; Michael Jarman; R Charles Coombes
Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee.
Cancer chemotherapy and pharmacology 1998;42(2):111-7.
1997: PE Pace; J Taylor; S Suntharalingam; R Charles Coombes; Simak Ali
Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha.
The Journal of biological chemistry 1997;272(41):25832-8.
1997: jennifer gomm; PJ Browne; RC Coope; GS Bansal; Constantino Yiangou; CL Johnston; R Mason; R Charles Coombes
A paracrine role for myoepithelial cell-derived FGF2 in the normal human breast.
Experimental cell research 1997;234(1):165-73.
1997: A Schoenfeld; K H Kruger; jennifer gomm; H D Sinnett; JC Gazet; N Sacks; H G Bender; Yunus A Luqmani; R Charles Coombes
The detection of micrometastases in the peripheral blood and bone marrow of patients with breast cancer using immunohistochemistry and reverse transcriptase polymerase chain reaction for keratin 19.
European journal of cancer (Oxford, England : 1990) 1997;33(6):854-61.
1997: jennifer gomm; RC Coope; PJ Browne; R Charles Coombes
Separated human breast epithelial and myoepithelial cells have different growth factor requirements in vitro but can reconstitute normal breast lobuloalveolar structure.
Journal of cellular physiology 1997;171(1):11-9.
1997: Constantino Yiangou; H Cox; GS Bansal; RC Coope; jennifer gomm; R Barnard; J Walters; N Groome; Sami Shousha; R Charles Coombes; CL Johnston
Down-regulation of a novel form of fibroblast growth factor receptor 1 in human breast cancer.
British journal of cancer 1997;76(11):1419-27.
1997: PE Pace; Michael Jarman; D Phillips; Alan Hewer; J Bliss; R Charles Coombes
Idoxifene is equipotent to tamoxifen in inhibiting mammary carcinogenesis but forms lower levels of hepatic DNA adducts.
British journal of cancer 1997;76(6):700-4.
1997: RC Coope; PJ Browne; Constantino Yiangou; GS Bansal; J Walters; N Groome; Sami Shousha; CL Johnston; R Charles Coombes; jennifer gomm
The location of acidic fibroblast growth factor in the breast is dependent on the activity of proteases present in breast cancer tissue.
British journal of cancer 1997;75(11):1621-30.
1997: GS Bansal; H C Cox; S Marsh; jennifer gomm; Constantino Yiangou; Yunus A Luqmani; R Charles Coombes; CL Johnston
Expression of keratinocyte growth factor and its receptor in human breast cancer.
British journal of cancer 1997;75(11):1567-74.
1997: Constantino Yiangou; jennifer gomm; RC Coope; M Law; Yunus A Luqmani; Sami Shousha; R Charles Coombes; CL Johnston
Fibroblast growth factor 2 in breast cancer: occurrence and prognostic significance.
British journal of cancer 1997;75(1):28-33.
1996: C N Rees; D Sinnett; C Lowdell; J English; R Charles Coombes
A pilot study to evaluate paclitaxel (Taxol) as primary medical treatment for patients with inoperable stage III and IV breast carcinoma.
European journal of cancer (Oxford, England : 1990) 1996;32A(13):2354-6.
1996: A Schoenfeld; Yunus A Luqmani; H Dudley Sinnett; Sami Shousha; R Charles Coombes
Keratin 19 mRNA measurement to detect micrometastases in lymph nodes in breast cancer patients.
British journal of cancer 1996;74(10):1639-42.
1996: R Baillie; R Charles Coombes; J Smith
Multiple forms of TGF-beta 1 in breast tissues: a biologically active form of the small latent complex of TGF-beta 1.
European journal of cancer (Oxford, England : 1990) 1996;32A(9):1566-73.
1996: G K Poon; D Vigushin; L J Griggs; Martin G Rowlands; R Charles Coombes; Michael Jarman
Identification and characterization of limonene metabolites in patients with advanced cancer by liquid chromatography/mass spectrometry.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(5):565-71.
1996: Yunus A Luqmani; GS Bansal; C Mortimer; Lakjaya Buluwela; R Charles Coombes
Expression of FGFR2 BEK and K-SAM mRNA variants in normal and malignant human breast.
European journal of cancer (Oxford, England : 1990) 1996;32A(3):518-24.
1996: Q Y Liu; B Niranjan; P Gomes; jennifer gomm; D Davies; R Charles Coombes; Lakjaya Buluwela
Inhibitory effects of activin on the growth and morpholgenesis of primary and transformed mammary epithelial cells.
Cancer research 1996;56(5):1155-63.
1996: R Charles Coombes; J M Bliss; Jacques A Wils; F Morvan; Marc Espié; D Amadori; P Gambrosier; M Richards; M Aapro; A Villar-Grimalt; C McArdle; Faustino R. Pérez-López; P Vassilopoulos; E P Ferreira; Clair E D Chilvers; G Coombes; E M Woods; Michel Marty
Adjuvant cyclophosphamide, methotrexate, and fluorouracil versus fluorouracil, epirubicin, and cyclophosphamide chemotherapy in premenopausal women with axillary node-positive operable breast cancer: results of a randomized trial. The International Collaborative Cancer Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(1):35-45.
1995: CL Johnston; H C Cox; jennifer gomm; R Charles Coombes
Fibroblast growth factor receptors (FGFRs) localize in different cellular compartments. A splice variant of FGFR-3 localizes to the nucleus.
The Journal of biological chemistry 1995;270(51):30643-50.
1995: GS Bansal; Constantino Yiangou; RC Coope; jennifer gomm; Yunus A Luqmani; R Charles Coombes; CL Johnston
Expression of fibroblast growth factor 1 is lower in breast cancer than in the normal human breast.
British journal of cancer 1995;72(6):1420-6.
1995: Yunus A Luqmani; C Mortimer; Constantino Yiangou; CL Johnston; GS Bansal; D Sinnett; M Law; R Charles Coombes
Expression of 2 variant forms of fibroblast growth factor receptor 1 in human breast.
International journal of cancer. Journal international du cancer 1995;64(4):274-9.
1995: jennifer gomm; P J Browne; RC Coope; Q Y Liu; Lakjaya Buluwela; R Charles Coombes
Isolation of pure populations of epithelial and myoepithelial cells from the normal human mammary gland using immunomagnetic separation with Dynabeads.
Analytical biochemistry 1995;226(1):91-9.
1995: R Charles Coombes; BP Haynes; Mitch Dowsett; M Quigley; J English; I R Judson; L J Griggs; G A Potter; R McCague; Michael Jarman
Idoxifene: report of a phase I study in patients with metastatic breast cancer.
Cancer research 1995;55(5):1070-4.
1995: CL Johnston; H C Cox; jennifer gomm; R Charles Coombes
bFGF and aFGF induce membrane ruffling in breast cancer cells but not in normal breast epithelial cells: FGFR-4 involvement.
The Biochemical journal 1995;306 ( Pt 2)():609-16.
1994: A Schoenfeld; Yunus A Luqmani; D Smith; S O'Reilly; Sami Shousha; H Dudley Sinnett; R Charles Coombes
Detection of breast cancer micrometastases in axillary lymph nodes by using polymerase chain reaction.
Cancer research 1994;54(11):2986-90.
1994: S K Chander; A G Lansdown; Yunus A Luqmani; jennifer gomm; RC Coope; N Gould; R Charles Coombes
Effectiveness of combined limonene and 4-hydroxyandrostenedione in the treatment of NMU-induced rat mammary tumours.
British journal of cancer 1994;69(5):879-82.
1994: T R J Evans; M G Rowlands; S S Sahota; R Charles Coombes
Lack of inhibition of placental estrone sulfatase and aromatase enzymes by vitamin D3 and its analogs.
The Journal of steroid biochemistry and molecular biology 1994;48(5-6):563-6.
1994: T R J Evans; M G Rowlands; M Law; R Charles Coombes
Intratumoral oestrone sulphatase activity as a prognostic marker in human breast carcinoma.
British journal of cancer 1994;69(3):555-61.
1994: R Charles Coombes; Clair E D Chilvers; D Amadori; F Medi; G Fountzilas; H Rauschecker; P Vassilopoulos; E P Ferreira; G Vannozzi; J M Bliss
Randomised trial of epirubicin versus fluorouracil in advanced gastric cancer. An International Collaborative Cancer Group (ICCG) study.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1994;5(1):33-6.
1994: P A Murray; jennifer gomm; D Ricketts; T Powles; R Charles Coombes
The effect of endocrine therapy on the levels of oestrogen and progesterone receptor and transforming growth factor-beta 1 in metastatic human breast cancer: an immunocytochemical study.
European journal of cancer (Oxford, England : 1990) 1994;30A(9):1218-22.
1994: J Smith; A Yelland; R Baillie; R Charles Coombes
Acidic and basic fibroblast growth factors in human breast tissue.
European journal of cancer (Oxford, England : 1990) 1994;30A(4):496-503.
1993: T R J Evans; M G Rowlands; Yunus A Luqmani; S K Chander; R Charles Coombes
Detection of breast cancer-associated estrone sulfatase in breast cancer biopsies and cell lines using polymerase chain reaction.
The Journal of steroid biochemistry and molecular biology 1993;46(2):195-201.
1993: Yunus A Luqmani; D Ricketts; G Ryall; L Turnbull; M Law; R Charles Coombes
Prediction of response to endocrine therapy in breast cancer using immunocytochemical assays for pS2, oestrogen receptor and progesterone receptor.
International journal of cancer. Journal international du cancer 1993;54(4):619-23.
1993: P A Murray; P Barrett-Lee; M Travers; Yunus A Luqmani; Trevor J Powles; R Charles Coombes
The prognostic significance of transforming growth factors in human breast cancer.
British journal of cancer 1993;67(6):1408-12.
1993: Yunus A Luqmani; T Campbell; S Soomro; Sami Shousha; M C Rio; R Charles Coombes
Immunohistochemical localisation of pS2 protein in ductal carcinoma in situ and benign lesions of the breast.
British journal of cancer 1993;67(4):749-53.
1993: T R J Evans; M G Rowlands; M C Silva; M Law; R Charles Coombes
Prognostic significance of aromatase and estrone sulfatase enzymes in human breast cancer.
The Journal of steroid biochemistry and molecular biology 1993;44(4-6):583-7.
1993: R Charles Coombes; Michael Jarman; Mitch Dowsett; S K Chander; M G Rowlands; E Di Salle; T J Evans
New endocrine agents for the treatment of breast cancer.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1993;127():267-75.
1993: T R J Evans; R C Stein; J R Pepper; J C Gazet; H T Ford; R Charles Coombes
A randomised prospective trial of surgical against medical tetracycline pleurodesis in the management of malignant pleural effusions secondary to breast cancer.
European journal of cancer (Oxford, England : 1990) 1993;29A(3):316-9.
1993: Jacques A Wils; R Charles Coombes; Michel Marty; J Bliss; E Woods
Design and rationale of a randomised comparison of cyclophosphamide, methotrexate and fluorouracil vs fluorouracil, epirubicin and cyclophosphamide in node-positive premenopausal women with operable breast cancer. A trial of the International Collaborative Cancer Group (ICCG).
Drugs 1993;45 Suppl 2():46-50; discussion 49-50.
1992: Michael J Seckl; Gordon J S Rustin; R Charles Coombes
CA-125 is not a useful marker in metastatic breast cancer.
British journal of cancer 1992;66(5):875-6.
1992: T R J Evans; E di Salle; G Ornati; M Lassus; M S Benedetti; E Pianezzola; R Charles Coombes
Phase I and endocrine study of exemestane (FCE 24304), a new aromatase inhibitor, in postmenopausal women.
Cancer research 1992;52(21):5933-9.
1992: R Charles Coombes
4-Hydroxyandrostenedione treatment for postmenopausal patients with breast cancer.
The Journal of steroid biochemistry and molecular biology 1992;43(1-3):145-8.
1992: E di Salle; G Ornati; D Giudici; M Lassus; T R J Evans; R Charles Coombes
Exemestane (FCE 24304), a new steroidal aromatase inhibitor.
The Journal of steroid biochemistry and molecular biology 1992;43(1-3):137-43.
1992: Yunus A Luqmani; M Graham; R Charles Coombes
Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues.
British journal of cancer 1992;66(2):273-80.
1992: A Jameel; R A Skilton; T A Campbell; S K Chander; R Charles Coombes; Yunus A Luqmani
Clinical and biological significance of HSP89 alpha in human breast cancer.
International journal of cancer. Journal international du cancer 1992;50(3):409-15.
1992: Y A Luqmani; J Smith; R Charles Coombes
Polymerase chain reaction-aided analysis of gene expression in frozen tissue sections.
Analytical biochemistry 1992;200(2):291-5.
1992: Yunus A Luqmani; G Ryall; Sami Shousha; R Charles Coombes
An immunohistochemical survey of pS2 expression in human epithelial cancers.
International journal of cancer. Journal international du cancer 1992;50(2):302-4.
1992: T R J Evans; R C Stein; H T Ford; J C Gazet; G V Chamberlain; R Charles Coombes
Lactic acidosis. A presentation of metastatic breast cancer arising in pregnancy.
Cancer 1992;69(2):453-6.
1992: T R J Evans; S K Chander; M G Rowlands; R Charles Coombes
Oestrone sulphatase activity in mammary tumours and the liver of N-nitrosomethylurea treated rats.
British journal of cancer 1992;65(1):72-6.
1992: T Campbell; R A Skilton; R Charles Coombes; Sami Shousha; M D Graham; Yunus A Luqmani
Isolation of a lactoferrin cDNA clone and its expression in human breast cancer.
British journal of cancer 1992;65(1):19-26.
1992: mark bower; R Stein; T R J Evans; A Hedley; P Pert; R Charles Coombes
A double-blind study of the efficacy of metronidazole gel in the treatment of malodorous fungating tumours.
European journal of cancer (Oxford, England : 1990) 1992;28A(4-5):888-9.
1992: R C Stein; mark bower; M Law; J M Bliss; C Barton; J C Gazet; H T Ford; R Charles Coombes
Mitozantrone and methotrexate chemotherapy with and without mitomycin C in the treatment of advanced breast cancer: a randomised clinical trial.
European journal of cancer (Oxford, England : 1990) 1992;28A(12):1963-5.
1992: R Charles Coombes; S W Hughes; Mitch Dowsett
4-hydroxyandrostenedione: a new treatment for postmenopausal patients with breast cancer.
European journal of cancer (Oxford, England : 1990) 1992;28A(12):1941-5.
1992: D Ricketts; L Hadcocks; M Fitzek; Nigel Rawson; K Colston; T J Powles; J C Gazet; R Charles Coombes
Serum markers for primary and recurrent breast cancer: BCM-EIA, CAM 26 and CAM 29.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1992;13(4):207-16.
1992: R C Stein; A E Joseph; S A Matlin; D C Cunningham; H T Ford; R Charles Coombes
A preliminary clinical study of gossypol in advanced human cancer.
Cancer chemotherapy and pharmacology 1992;30(6):480-2.
1991: Yunus A Luqmani; T A Campbell; C Bennett; R Charles Coombes; I M Paterson
Expression of lactoferrin in human stomach.
International journal of cancer. Journal international du cancer 1991;49(5):684-7.
1991: T R J Evans; M G Rowlands; Michael Jarman; R Charles Coombes
Inhibition of estrone sulfatase enzyme in human placenta and human breast carcinoma.
The Journal of steroid biochemistry and molecular biology 1991;39(4A):493-9.
1991: jennifer gomm; J Smith; G K Ryall; R Baillie; L Turnbull; R Charles Coombes
Localization of basic fibroblast growth factor and transforming growth factor beta 1 in the human mammary gland.
Cancer research 1991;51(17):4685-92.
1991: R Charles Coombes; J R Wilkinson; J M Bliss; P Shah; D F Easton; M Dowsett
4-Hydroxyandrostenedione in the prophylaxis of N-methyl-N-nitrosourea induced mammary tumourigenesis.
British journal of cancer 1991;64(2):247-50.
1991: D Ricketts; L Turnbull; G Ryall; R Bakhshi; Nigel Rawson; J C Gazet; C Nolan; R Charles Coombes
Estrogen and progesterone receptors in the normal female breast.
Cancer research 1991;51(7):1817-22.
1991: mark bower; R C Stein; A Hedley; J Davenport; Kay W Colston; R Charles Coombes
The use of nasal calcitonin spray in the treatment of hypercalcaemia of malignancy.
Cancer chemotherapy and pharmacology 1991;28(4):311-2.
1991: BP Haynes; Michael Jarman; Mitch Dowsett; A Mehta; P E Lønning; L J Griggs; A Jones; T Powles; R Stein; R Charles Coombes
Pharmacokinetics and pharmacodynamics of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione in patients with postmenopausal breast cancer.
Cancer chemotherapy and pharmacology 1991;27(5):367-72.
1991: U Berger; R A McClelland; P Wilson; G L Greene; M R Haussler; J W Pike; K Colston; D Easton; R Charles Coombes
Immunocytochemical determination of estrogen receptor, progesterone receptor, and 1,25-dihydroxyvitamin D3 receptor in breast cancer and relationship to prognosis.
Cancer research 1991;51(1):239-44.
1991: C Evans; R C Stein; J Davenport; L Dougherty; L Carruthers; R Charles Coombes
Comparison of ondansetron with dexamethasone and domperidone in the prophylaxis of non-cisplatin chemotherapy induced emesis refractory to dexamethasone.
European journal of cancer (Oxford, England : 1990) 1991;27(3):302-3.
1990: R Charles Coombes; P Barrett-Lee; Yunus A Luqmani
Growth factor expression in breast tissue.
The Journal of steroid biochemistry and molecular biology 1990;37(6):833-6.
1990: R C Stein; Mitch Dowsett; A Hedley; J C Gazet; H T Ford; R Charles Coombes
The clinical and endocrine effects of 4-hydroxyandrostenedione alone and in combination with goserelin in premenopausal women with advanced breast cancer.
British journal of cancer 1990;62(4):679-83.
1990: R Charles Coombes; P S Schein; Clair E D Chilvers; Jacques A Wils; G Beretta; J M Bliss; A Rutten; D Amadori; H Cortes-Funes; A Villar-Grimalt
A randomized trial comparing adjuvant fluorouracil, doxorubicin, and mitomycin with no treatment in operable gastric cancer. International Collaborative Cancer Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1990;8(8):1362-9.
1990: Mitch Dowsett; R C Stein; A Mehta; R Charles Coombes
Potency and selectivity of the non-steroidal aromatase inhibitor CGS 16949A in postmenopausal breast cancer patients.
Clinical endocrinology 1990;32(5):623-34.
1990: P Barrett-Lee; M Travers; Yunus A Luqmani; R Charles Coombes
Transcripts for transforming growth factors in human breast cancer: clinical correlates.
British journal of cancer 1990;61(4):612-7.
1990: R C Stein; Mitch Dowsett; D C Cunningham; J Davenport; H T Ford; J C Gazet; E von Angerer; R Charles Coombes
Phase I/II study of the anti-oestrogen zindoxifene (D16726) in the treatment of advanced breast cancer. A Cancer Research Campaign Phase I/II Clinical Trials Committee study.
British journal of cancer 1990;61(3):451-3.
1990: R C Stein; Mitch Dowsett; J Davenport; A Hedley; H T Ford; J C Gazet; R Charles Coombes
Preliminary study of the treatment of advanced breast cancer in postmenopausal women with the aromatase inhibitor CGS 16949A.
Cancer research 1990;50(5):1381-4.
1990: R C Stein; Mitch Dowsett; A Hedley; J Davenport; J C Gazet; H T Ford; R Charles Coombes
Treatment of advanced breast cancer in postmenopausal women with 4-hydroxyandrostenedione.
Cancer chemotherapy and pharmacology 1990;26(1):75-8.
1990: R A Skilton; Helena Earl; M E Gore; R A McIlhinney; barry gusterson; P Wilson; R Charles Coombes; A M Neville
Characterization of monoclonal antibodies reactive with normal resting, lactating and neoplastic human breast.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1990;11(1-2):20-38.
1989: Helena Earl; R A McIlhinney; P Wilson; barry gusterson; R Charles Coombes
Immunohistochemical study of beta- and kappa-casein in the human breast and breast carcinomas, using monoclonal antibodies.
Cancer research 1989;49(21):6070-6.
1989: U Berger; P Wilson; S Thethi; R A McClelland; G L Greene; R Charles Coombes
Comparison of an immunocytochemical assay for progesterone receptor with a biochemical method of measurement and immunocytochemical examination of the relationship between progesterone and estrogen receptors.
Cancer research 1989;49(18):5176-9.
1989: R A Skilton; Yunus A Luqmani; R A McClelland; R Charles Coombes
Characterisation of a messenger RNA selectively expressed in human breast cancer.
British journal of cancer 1989;60(2):168-75.
1989: J L Mansi; U Berger; T McDonnell; A Pople; Z Rayter; J C Gazet; R Charles Coombes
The fate of bone marrow micrometastases in patients with primary breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989;7(4):445-9.
1989: Mitch Dowsett; D C Cunningham; R C Stein; S Evans; L Dehennin; A Hedley; R Charles Coombes
Dose-related endocrine effects and pharmacokinetics of oral and intramuscular 4-hydroxyandrostenedione in postmenopausal breast cancer patients.
Cancer research 1989;49(5):1306-12.
1989: P Shah; P H van der Meide; T Borman; N Schroeder; J M Bliss; R Charles Coombes
Effect of human recombinant tumour necrosis factor and rat gamma interferon on nitrosomethylurea-induced mammary tumours.
British journal of cancer 1989;59(2):206-9.
1988: K W Colston; U Berger; P Wilson; L Hadcocks; I Naeem; Helena Earl; R Charles Coombes
Mammary gland 1,25-dihydroxyvitamin D3 receptor content during pregnancy and lactation.
Molecular and cellular endocrinology 1988;60(1):15-22.
1988: U Berger; P Wilson; R A McClelland; K Colston; M R Haussler; J W Pike; R Charles Coombes
Immunocytochemical detection of 1,25-dihydroxyvitamin D receptors in normal human tissues.
The Journal of clinical endocrinology and metabolism 1988;67(3):607-13.
1988: J L Mansi; Wilma E Mesker; T McDonnell; A M Van Driel-Kulker; J S Ploem; R Charles Coombes
Automated screening for micrometastases in bone marrow smears.
Journal of immunological methods 1988;112(1):105-111.
1988: U Berger; R Bettelheim; J L Mansi; D Easton; R Charles Coombes; A M Neville
The relationship between micrometastases in the bone marrow, histopathologic features of the primary tumor in breast cancer and prognosis.
American journal of clinical pathology 1988;90(1):1-6.
1988: M T Travers; P J Barrett-Lee; U Berger; Yunus A Luqmani; J C Gazet; Trevor J Powles; R Charles Coombes
Growth factor expression in normal, benign, and malignant breast tissue.
British medical journal (Clinical research ed.) 1988;296(6637):1621-4.
1988: J L Mansi; U Berger; P Wilson; R Shearer; R Charles Coombes
Detection of tumor cells in bone marrow of patients with prostatic carcinoma by immunocytochemical techniques.
The Journal of urology 1988;139(3):545-8.
1987: P J Barrett-Lee; M T Travers; R A McClelland; Yunus A Luqmani; R Charles Coombes
Characterization of estrogen receptor messenger RNA in human breast cancer.
Cancer research 1987;47(24 Pt 1):6653-9.
1987: U Berger; P Wilson; R A McClelland; K Colston; M R Haussler; J W Pike; R Charles Coombes
Immunocytochemical detection of 1,25-dihydroxyvitamin D3 receptor in breast cancer.
Cancer research 1987;47(24 Pt 1):6793-9.
1987: U Berger; P Wilson; R A McClelland; J Davidson; R Charles Coombes
Correlation of immunocytochemically demonstrated estrogen receptor distribution and histopathologic features in primary breast cancer.
Human pathology 1987;18(12):1263-7.
1987: R A McClelland; U Berger; P Wilson; Trevor J Powles; PA Trott; D Easton; J C Gazet; R Charles Coombes
Presurgical determination of estrogen receptor status using immunocytochemically stained fine needle aspirate smears in patients with breast cancer.
Cancer research 1987;47(22):6118-22.
1987: U Berger; J L Mansi; P Wilson; R Charles Coombes
Detection of estrogen receptor in bone marrow from patients with metastatic breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1987;5(11):1779-82.
1987: D Cunningham; J C Gazet; H T Ford; R Charles Coombes
Oral gestrinone: a novel antiprogestin with no antitumor activity in endocrine-sensitive breast cancer.
Cancer treatment reports 1987;71(11):1091-2.
1987: J L Mansi; U Berger; D Easton; T McDonnell; W H Redding; J C Gazet; A McKinna; Trevor J Powles; R Charles Coombes
Micrometastases in bone marrow in patients with primary breast cancer: evaluation as an early predictor of bone metastases.
British medical journal (Clinical research ed.) 1987;295(6606):1093-6.
1987: R Charles Coombes; Trevor J Powles; U Berger; P Wilson; R A McClelland; J C Gazet; PA Trott; H T Ford
Prediction of endocrine response in breast cancer by immunocytochemical detection of oestrogen receptor in fine-needle aspirates.
Lancet 1987;2(8561):701-3.
1987: R Charles Coombes; P E Goss; M Dowsett; G Hutchinson; D Cunningham; M Jarman; Angela Brodie
4-Hydroxyandrostenedione treatment for postmenopausal patients with advanced breast cancer.
Steroids 1987;50(1-3):245-52.
1987: D Cunningham; J Hawthorn; A Pople; J C Gazet; H T Ford; T Challoner; R Charles Coombes
Prevention of emesis in patients receiving cytotoxic drugs by GR38032F, a selective 5-HT3 receptor antagonist.
Lancet 1987;1(8548):1461-3.
1987: R Charles Coombes; Trevor J Powles; D Easton; C Chilvers; H T Ford; I E Smith; A McKinna; H White; J Bradbeer; J Yarnold
Adjuvant aminoglutethimide therapy for postmenopausal patients with primary breast cancer.
Cancer research 1987;47(9):2494-7.
1986: R Charles Coombes; U Berger; J Mansi; H Redding; Trevor J Powles; A M Neville; A McKinna; A G Nash; J C Gazet; H T Ford
Prognostic significance of micrometastases in bone marrow in patients with primary breast cancer.
NCI monographs : a publication of the National Cancer Institute 1986;(1):51-3.
1984: Trevor J Powles; S Ashley; H T Ford; J C Gazet; A G Nash; A M Neville; R Charles Coombes
Treatment of disseminated breast cancer with tamoxifen, aminoglutethimide, hydrocortisone, and danazol, used in combination or sequentially.
Lancet 1984;1(8391):1369-73.
1984: H C Freake; G Abeyasekera; J Iwasaki; C Marcocci; I MacIntyre; R A McClelland; R A Skilton; D F Easton; R Charles Coombes
Measurement of 1,25-dihydroxyvitamin D3 receptors in breast cancer and their relationship to biochemical and clinical indices.
Cancer research 1984;44(4):1677-81.
1983: Michael Jarman; A B Foster; P E Goss; L J Griggs; I Howe; R Charles Coombes
Metabolism of aminoglutethimide in humans: identification of hydroxylaminoglutethimide as an induced metabolite.
Biomedical mass spectrometry 1983;10(11):620-5.
1983: A L Harris; Trevor J Powles; Ian E Smith; R Charles Coombes; H T Ford; J C Gazet; C L Harmer; M Morgan; H White; C A Parsons; J A McKinna
Aminoglutethimide for the treatment of advanced postmenopausal breast cancer.
European journal of cancer & clinical oncology 1983;19(1):11-17.
1982: R Charles Coombes; Trevor J Powles; L H Rees; W A Ratcliffe; A G Nash; M Henk; H T Ford; J C Gazet; A M Neville
Tamoxifen, aminoglutethimide and danazol: effect of therapy on hormones in post-menopausal patients with breast cancer.
British journal of cancer 1982;46(1):30-4.
1982: R E Taylor; T J Powles; J Humphreys; R Bettelheim; M Dowsett; A J Casey; A M Neville; R Charles Coombes
Effects of endocrine therapy on steroid-receptor content of breast cancer.
British journal of cancer 1982;45(1):80-5.
1981: R Charles Coombes; Trevor J Powles; J C Gazet; H T Ford; A McKinna; M Abbott; C W Gehrke; J W Keyser; P E Mitchell; S Patel; W H Stimson; M Worwood; M Jones; A M Neville
Screening for metastases in breast cancer: an assessment of biochemical and physical methods.
Cancer 1981;48(2):310-5.
1980: R Charles Coombes; D Dearnaley; J Humphreys; J C Gazet; H T Ford; A G Nash; K Mashiter; Trevor J Powles
Danazol treatment of advanced breast cancer.
Cancer treatment reports 1980;64(10-11):1073-6.
1980: R Charles Coombes; Trevor J Powles; J C Gazet; A G Nash; H T Ford; A McKinna; A M Neville
Assessment of biochemical tests to screen for metastases in patients with breast cancer.
Lancet 1980;1(8163):296-7.
1980: Ian E Smith; R Charles Coombes; H T Ford; J C Gazet; C Harmer; M Jones; J A McKinna; Trevor J Powles
Aminoglutethimide in the management of advanced breast cancer.
European journal of cancer 1980;Suppl 1():99-101.
1980: P J Dady; R Charles Coombes; Ian E Smith; C A Parsons; H T Ford; J C Gazet; J M Henk; A G Nash; Trevor J Powles
Use of an antiosteolytic agent in treatment of patients with bone metastases from breast cancer.
European journal of cancer 1980;Suppl 1():131-5.
1980: R Charles Coombes; Trevor J Powles; H T Ford; J C Gazet; C W Gehrke; J W Keyser; P E Mitchell; S Patel; W H Stimson; M Abbott; M Worwood; A M Neville
The value of sequential marker estimations following mastectomy for breast cancer.
European journal of cancer 1980;Suppl 1():25-30.