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Agata Copani

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Giuseppe Pandini; Sebastiano Squatrito; Agata Copani; Danilo Milardi; Vincenza Pace; Riccardo Vigneri
Insulin has multiple antiamyloidogenic effects on human neuronal cells.
Luisa Di Menna; Luigi Di Nuzzo; Gemma Molinaro; Ferdinando Nicoletti; Carlo Pozzilli; Barbara Riozzi; Renato Turrini; Cristina Zappulla; Giuseppe Battaglia; Filippo Caraci; Agata Copani; Valeria Bruno
Fingolimod protects cultured cortical neurons against excitotoxic death.
Maria Laura Giuffrida; Ferdinando Nicoletti; Flora Tomasello; Filippo Caraci; Santina Chiechio; Agata Copani
Beta-amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease.

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All Publications

2013: Giuseppe Pandini; Sebastiano Squatrito; Agata Copani; Danilo Milardi; Vincenza Pace; Riccardo Vigneri
Insulin has multiple antiamyloidogenic effects on human neuronal cells.
Endocrinology 2013;154(1):375-87.
2013: Luisa Di Menna; Luigi Di Nuzzo; Gemma Molinaro; Ferdinando Nicoletti; Carlo Pozzilli; Barbara Riozzi; Renato Turrini; Cristina Zappulla; Giuseppe Battaglia; Filippo Caraci; Agata Copani; Valeria Bruno
Fingolimod protects cultured cortical neurons against excitotoxic death.
Pharmacological research : the official journal of the Italian Pharmacological Society 2013;67(1):1-9.
2012: Maria Laura Giuffrida; Ferdinando Nicoletti; Flora Tomasello; Filippo Caraci; Santina Chiechio; Agata Copani
Beta-amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease.
Molecular neurobiology 2012;46(3):605-13.
2012: Filippo Caraci; Agata Copani; Gemma Molinaro; Ferdinando Nicoletti; Maria Angela Sortino; Simona Spampinato; Giuseppe Battaglia; Valeria Bruno
Metabotropic glutamate receptors in neurodegeneration/neuroprotection: still a hot topic?
Neurochemistry international 2012;61(4):559-65.
2012: Filippo Caraci; Agata Copani; Filomena I Cosentino; Filippo Drago; Eugenio Aguglia; Cinzia Bonforte; Paolo Bosco; Maria Concetta Giambirtone; Eleonora Gulotta; Stefano Muratore; Ferdinando Nicoletti; Simonetta Panerai; Giuseppina Prestianni; Carmelo Romano; Maria Grazia Salluzzo; Maria Signorelli; Rosario S Spada; Giuseppe Toscano; Raffaele Ferri
The CC genotype of transforming growth factor-β1 increases the risk of late-onset Alzheimer's disease and is associated with AD-related depression.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2012;22(4):281-9.
2012: marco calafiore; Agata Copani; Wenbin Deng
DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres.
Journal of neuroscience research 2012;90(3):559-67.
2011: Filippo Caraci; Viviana Carbonaro; Giuseppe Battaglia; Paolo Bosco; Valeria Bruno; Filippo Drago; Maria Laura Giuffrida; Ferdinando Nicoletti; Maria Angela Sortino; Agata Copani
TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease.
CNS neuroscience & therapeutics 2011;17(4):237-49.
2011: Filippo Caraci; Venerando Pistarà; A Corsaro; Flora Tomasello; Maria Laura Giuffrida; Maria Angela Sortino; Ferdinando Nicoletti; Agata Copani
Neurotoxic properties of the anabolic androgenic steroids nandrolone and methandrostenolone in primary neuronal cultures.
Journal of neuroscience research 2011;89(4):592-600.
2011: Filippo Caraci; Gemma Molinaro; Giuseppe Battaglia; Maria Laura Giuffrida; Barbara Riozzi; Anna Traficante; Valeria Bruno; Milena Cannella; Sara Merlo; Xushan Wang; Beverly A Heinz; Eric S Nisenbaum; Thomas C Britton; Filippo Drago; Maria Angela Sortino; Agata Copani; Ferdinando Nicoletti
Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective.
Molecular pharmacology 2011;79(3):618-26.
2011: Simona Spampinato; Angela Trabucco; Francesca Biagioni; Antonella Biasiotta; William H Colledge; Agata Copani; Giorgio Cruccu; Ferdinando Nicoletti; Maria Angela Sortino; Santina Chiechio
Hyperalgesic activity of kisspeptin in mice.
Molecular pain 2011;7():90.
2011: Francesco Matrisciano; Carla L Busceti; Domenico Bucci; Rosamaria Orlando; Alessandra Caruso; Gemma Molinaro; Irene Cappuccio; Barbara Riozzi; Roberto Gradini; Marta Motolese; Filippo Caraci; Agata Copani; Sergio Scaccianoce; Daniela Melchiorri; Valeria Bruno; Giuseppe Battaglia; Ferdinando Nicoletti
Induction of the Wnt antagonist Dickkopf-1 is involved in stress-induced hippocampal damage.
PloS one 2011;6(1):e16447.
2011: Magda Zammataro; Santina Chiechio; Michael C Montana; Anna Traficante; Agata Copani; Ferdinando Nicoletti; Robert W Gereau
mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists.
Molecular pain 2011;7():6.
2010: Sara Merlo; Simona Spampinato; Pier Luigi Canonico; Agata Copani; Maria Angela Sortino
Alzheimer's disease: brain expression of a metabolic disorder?
Trends in endocrinology and metabolism: TEM 2010;21(9):537-44.
2010: Santina Chiechio; Agata Copani; Magda Zammataro; Giuseppe Battaglia; Robert W Gereau; Ferdinando Nicoletti
Transcriptional regulation of type-2 metabotropic glutamate receptors: an epigenetic path to novel treatments for chronic pain.
Trends in pharmacological sciences 2010;31(4):153-60.
2010: Filippo Caraci; Agata Copani; Ferdinando Nicoletti; Filippo Drago
Depression and Alzheimer's disease: neurobiological links and common pharmacological targets.
European journal of pharmacology 2010;626(1):64-71.
2010: Mario Giuffrida; Filippo Caraci; P De Bona; Giuseppe Pappalardo; Ferdinando Nicoletti; Enrico Rizzarelli; Agata Copani
The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology.
Reviews in the neurosciences 2010;21(2):83-93.
2009: Maria Laura Giuffrida; Filippo Caraci; Bruno Pignataro; Sebastiano Cataldo; Paolo De Bona; Valeria Bruno; Gemma Molinaro; Giuseppe Pappalardo; Angela Messina; Angelo Palmigiano; Domenico Garozzo; Ferdinando Nicoletti; Enrico Rizzarelli; Agata Copani
Beta-amyloid monomers are neuroprotective.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(34):10582-7.
2009: Santina Chiechio; M Zammataro; M E Morales; C L Busceti; F Drago; Robert W Gereau; Agata Copani; Ferdinando Nicoletti
Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain.
Molecular pharmacology 2009;75(5):1014-20.
2009: Paolo De Bona; Maria Laura Giuffrida; Filippo Caraci; Agata Copani; Bruno Pignataro; Francesco Attanasio; Sebastiano Cataldo; Giuseppe Pappalardo; Enrico Rizzarelli
Design and synthesis of new trehalose-conjugated pentapeptides as inhibitors of Abeta(1-42) fibrillogenesis and toxicity.
Journal of peptide science : an official publication of the European Peptide Society 2009;15(3):220-8.
2009: Viviana Carbonaro; Filippo Caraci; Maria Laura Giuffrida; Sara Merlo; Pier Luigi Canonico; Filippo Drago; Agata Copani; Maria Angela Sortino
Enhanced expression of ERalpha in astrocytes modifies the response of cortical neurons to beta-amyloid toxicity.
Neurobiology of disease 2009;33(3):415-21.
2009: Santina Chiechio; M Zammataro; Filippo Caraci; Liborio Rampello; Agata Copani; A F Sabato; F Nicoletti
Pregabalin in the treatment of chronic pain: an overview.
Clinical drug investigation 2009;29(3):203-13.
2008: Filippo Caraci; Carla Busceti; Francesca Biagioni; Eleonora Aronica; Federica Mastroiacovo; Irene Cappuccio; Giuseppe Battaglia; Valeria Bruno; Andrea Caricasole; Agata Copani; Ferdinando Nicoletti
The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders.
Neurochemical research 2008;33(12):2401-6.
2008: Marzia Castiglione; marco calafiore; Lara Costa; Maria Angela Sortino; Ferdinando Nicoletti; Agata Copani
Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice.
Neuropharmacology 2008;55(4):560-7.
2008: Filippo Caraci; Giuseppe Battaglia; Carla Busceti; Francesca Biagioni; Federica Mastroiacovo; Paolo Bosco; Filippo Drago; Ferdinando Nicoletti; Maria Angela Sortino; Agata Copani
TGF-beta 1 protects against Abeta-neurotoxicity via the phosphatidylinositol-3-kinase pathway.
Neurobiology of disease 2008;30(2):234-42.
2008: Filippo Caraci; Elisa Gili; marco calafiore; Marco Failla; Cristina La Rosa; Nunzio Crimi; Maria Angela Sortino; Ferdinando Nicoletti; Agata Copani; Carlo Vancheri
TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts.
Pharmacological research : the official journal of the Italian Pharmacological Society 2008;57(4):274-82.
2008: giuseppina frasca; Viviana Carbonaro; Sara Merlo; Agata Copani; Maria Angela Sortino
Integrins mediate beta-amyloid-induced cell-cycle activation and neuronal death.
Journal of neuroscience research 2008;86(2):350-5.
2008: Agata Copani; S Guccione; L Giurato; F Caraci; marco calafiore; M A Sortino; F Nicoletti
The cell cycle molecules behind neurodegeneration in Alzheimer's disease: perspectives for drug development.
Current medicinal chemistry 2008;15(24):2420-32.
2007: Paolo Bosco; Filippo Caraci; Agata Copani; Rosario S Spada; Maria Angela Sortino; Roberto Salluzzo; Michele Salemi; Ferdinando Nicoletti; Raffaele Ferri
The CDC2 I-G-T haplotype associated with the APOE epsilon4 allele increases the risk of sporadic Alzheimer's disease in Sicily.
Neuroscience letters 2007;419(3):195-8.
2007: Sara Merlo; marco calafiore; Carlo Vancheri; Pier Luigi Canonico; Agata Copani; Maria Angela Sortino
Astrocyte-like cells as a main target for estrogen action during neuronal differentiation.
Molecular and cellular neurosciences 2007;34(4):562-70.
2007: Agata Copani; Filippo Caraci; Jeroen J M Hoozemans; marco calafiore; Maria Angela Sortino; Ferdinando Nicoletti
The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death.
Biochimica et biophysica acta 2007;1772(4):409-12.
2007: Maria Laura Giuffrida; Giulia Grasso; Menotti Ruvo; Carlo Pedone; Angela Saporito; Daniela Marasco; Bruno Pignataro; Claudia Cascio; Agata Copani; Enrico Rizzarelli
Abeta(25-35) and its C- and/or N-blocked derivatives: copper driven structural features and neurotoxicity.
Journal of neuroscience research 2007;85(3):623-33.
2007: Santina Chiechio; Agata Copani; Robert W Gereau; Ferdinando Nicoletti
Acetyl-L-carnitine in neuropathic pain: experimental data.
CNS drugs 2007;21 Suppl 1():31-8; discussion 45-6.
2006: Carla Scali; Filippo Caraci; Marco Gianfriddo; Enrica Diodato; Renza Roncarati; Giuseppe Pollio; Giovanni Gaviraghi; Agata Copani; Ferdinando Nicoletti; Georg C Terstappen; Andrea Caricasole
Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.
Neurobiology of disease 2006;24(2):254-65.
2006: Agata Copani; Jeroen J M Hoozemans; Filippo Caraci; marco calafiore; Elise S van Haastert; Robert Veerhuis; Annemieke J M Rozemuller; Eleonora Aronica; Maria Angela Sortino; Ferdinando Nicoletti
DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(43):10949-57.
2006: Sabrina Paratore; Rosalba Parenti; Antonietta Torrisi; Agata Copani; Federico Cicirata; Sebastiano Cavallaro
Genomic profiling of cortical neurons following exposure to beta-amyloid.
Genomics 2006;88(4):468-79.
2006: Santina Chiechio; Agata Copani; Ferdinando Nicoletti; R W Gereau
L-acetylcarnitine: a proposed therapeutic agent for painful peripheral neuropathies.
Current neuropharmacology 2006;4(3):233-7.
2006: Alessandra Caruso; Marta Motolese; Luisa Iacovelli; Filippo Caraci; Agata Copani; Ferdinando Nicoletti; Georg C Terstappen; Giovanni Gaviraghi; Andrea Caricasole
Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells.
Journal of neurochemistry 2006;98(2):364-71.
2006: marco calafiore; Giuseppe Battaglia; Agata Zappalà; Elisa Trovato-Salinaro; Filippo Caraci; Massimo Caruso; Carlo Vancheri; Maria Angela Sortino; Ferdinando Nicoletti; Agata Copani
Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to beta-amyloid.
Neurobiology of aging 2006;27(4):606-13.
2006: Santina Chiechio; Agata Copani; Laura De Petris; Maria Elena P Morales; Ferdinando Nicoletti; Robert W Gereau
Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine.
Molecular pain 2006;2():20.
2005: Andrea Caricasole; A Bakker; Agata Copani; F Nicoletti; Giovanni Gaviraghi; Georg C Terstappen
Two sides of the same coin: Wnt signaling in neurodegeneration and neuro-oncology.
Bioscience reports 2005;25(5-6):309-27.
2005: Agostino Marrazzo; Filippo Caraci; Elisa Trovato Salinaro; Tsung-Ping Su; Agata Copani; Giuseppe Ronsisvalle
Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity.
Neuroreport 2005;16(11):1223-6.
2005: Filippo Caraci; Mariangela Chisari; giuseppina frasca; Pier Luigi Canonico; Angelo Battaglia; marco calafiore; Giuseppe Battaglia; Paolo Bosco; Ferdinando Nicoletti; Agata Copani; Maria Angela Sortino
Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against beta-amyloid toxicity.
Brain research 2005;1047(1):30-7.
2004: Mariangela Chisari; Salvatore Salomone; Floriana Laureanti; Agata Copani; Maria Angela Sortino
Modulation of cerebral vascular tone by activated glia: involvement of nitric oxide.
Journal of neurochemistry 2004;91(5):1171-9.
2004: Maria Angela Sortino; giuseppina frasca; Mariangela Chisari; Paola Platania; Santina Chiechio; Carlo Vancheri; Agata Copani; Pier Luigi Canonico
Novel neuronal targets for the acetylcholinesterase inhibitor donepezil.
Neuropharmacology 2004;47(8):1198-204.
2004: Maria Angela Sortino; Mariangela Chisari; S Merlo; Carlo Vancheri; M Caruso; Ferdinando Nicoletti; Pier Luigi Canonico; Agata Copani
Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death.
Endocrinology 2004;145(11):5080-6.
2004: Karl Herrup; Rachael Neve; Susan L Ackerman; Agata Copani
Divide and die: cell cycle events as triggers of nerve cell death.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(42):9232-9.
2004: Andrea Caricasole; Agata Copani; Filippo Caraci; Eleonora Aronica; Annemieke J M Rozemuller; Alessandra Caruso; marianna storto; Giovanni Gaviraghi; Georg C Terstappen; Ferdinando Nicoletti
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(26):6021-7.
2004: Santina Chiechio; Agata Copani; Daniela Melchiorri; A M Teixido Canudas; marianna storto; Menotti Calvani; R Nicolai; Ferdinando Nicoletti
Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain.
Journal of endocrinological investigation 2004;27(6 Suppl):171-6.
2004: giuseppina frasca; Santina Chiechio; Carlo Vancheri; Ferdinan Nicoletti; Agata Copani; Maria Angela Sortino
Beta-amyloid-activated cell cycle in SH-SY5Y neuroblastoma cells: correlation with the MAP kinase pathway.
Journal of molecular neuroscience : MN 2004;22(3):231-6.
2003: Andrea Caricasole; Agata Copani; Alessandra Caruso; Filippo Caraci; Luisa Iacovelli; Maria Angela Sortino; Georg C Terstappen; Ferdinando Nicoletti
The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease?
Trends in pharmacological sciences 2003;24(5):233-8.
2002: Agata Copani; Maria Angela Sortino; Andrea Caricasole; Santina Chiechio; Mariangela Chisari; Giuseppe Battaglia; Anna Maria Giuffrida-Stella; Carlo Vancheri; Ferdinando Nicoletti
Erratic expression of DNA polymerases by beta-amyloid causes neuronal death.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(14):2006-8.
2002: Andrea Caricasole; Valeria Bruno; Irene Cappuccio; Daniela Melchiorri; Agata Copani; Ferdinando Nicoletti
A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(10):1331-3.
2002: Agata Copani; Daniela Melchiorri; Andrea Caricasole; Francesca Martini; sale Patrizio; Roberto Carnevale; Roberto Gradini; Maria Angela Sortino; Luisa Lenti; Ruggero De Maria; Ferdinando Nicoletti
Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(10):3963-8.
2002: Santina Chiechio; Andrea Caricasole; Eliana Barletta; marianna storto; Maria Vincenza Catania; Agata Copani; M Vertechy; R Nicolai; Menotti Calvani; Daniela Melchiorri; Ferdinando Nicoletti
L-Acetylcarnitine induces analgesia by selectively up-regulating mGlu2 metabotropic glutamate receptors.
Molecular pharmacology 2002;61(5):989-96.
2002: Agata Copani; Maria Angela Sortino; Ferdinando Nicoletti; Stella A M Giuffrida
Alzheimer's disease research enters a "new cycle": how significant?
Neurochemical research 2002;27(1-2):173-6.
2001: Valeria Bruno; Giuseppe Battaglia; Agata Copani; Mara D'Onofrio; Patrizia Di Iorio; Antonio De Blasi; Daniela Melchiorri; Peter J Flor; Ferdinando Nicoletti
Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(9):1013-33.
2001: Daniela Melchiorri; Valeria Bruno; Gilbert Besong; Richard Teke Ngomba; Laura Cuomo; Antonio De Blasi; Agata Copani; CM Moschella; marianna storto; Ferdinando Nicoletti; G Lepperdinger; Francesca Passarelli
The mammalian homologue of the novel peptide Bv8 is expressed in the central nervous system and supports neuronal survival by activating the MAP kinase/PI-3-kinase pathways.
The European journal of neuroscience 2001;13(9):1694-702.
2001: Valeria Bruno; Giuseppe Battaglia; Agata Copani; V M Cespédes; Joaquin Jordan; Valentín Ceña; J Sánchez-Prieto; Fabrizio Gasparini; R Kuhn; Peter J Flor; Ferdinando Nicoletti
An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors.
The European journal of neuroscience 2001;13(8):1469-78.
2001: Agata Copani; Fabrizio Condorelli; Pier Luigi Canonico; Ferdinando Nicoletti; Maria Angela Sortino
Cell cycle progression towards Alzheimer's disease.
Functional neurology 2001;16(4 Suppl):11-5.
2001: Agata Copani; Daniela Uberti; Maria Angela Sortino; Valeria Bruno; F Nicoletti; Maurizio Memo
Activation of cell-cycle-associated proteins in neuronal death: a mandatory or dispensable path?
Trends in neurosciences 2001;24(1):25-31.
2000: Valeria Bruno; Agata Copani; Gilbert Besong; G Scoto; Ferdinando Nicoletti
Neuroprotective activity of chemokines against N-methyl-D-aspartate or beta-amyloid-induced toxicity in culture.
European journal of pharmacology 2000;399(2-3):117-21.
2000: Agata Copani; Carmelo Romano; Valeria Di Giorgi Gerevini; A Nicosia; G Casabona; marianna storto; V Mutel; Ferdinando Nicoletti
Reducing conditions differentially affect the functional and structural properties of group-I and -II metabotropic glutamate receptors.
Brain research 2000;867(1-2):165-72.
2000: Vittorio Calabrese; Agata Copani; D Testa; Agrippino Ravagna; F Spadaro; Elisabetta A Tendi; Vincenzo Giuseppe Nicoletti; Anna Maria Giuffrida-Stella
Nitric oxide synthase induction in astroglial cell cultures: effect on heat shock protein 70 synthesis and oxidant/antioxidant balance.
Journal of neuroscience research 2000;60(5):613-22.
2000: C Frati; Cinzia Marchese; G Fisichella; Agata Copani; M R Nasca; marianna storto; F Nicoletti
Expression of functional mGlu5 metabotropic glutamate receptors in human melanocytes.
Journal of cellular physiology 2000;183(3):364-72.
2000: Giuseppe Battaglia; M La Russa; Valeria Bruno; L Arenare; R Ippolito; Agata Copani; Francesco Bonina; F Nicoletti
Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents.
Brain research 2000;860(1-2):149-56.
2000: marianna storto; U de Grazia; T Knöpfel; Pier Luigi Canonico; Agata Copani; Plinio Richelmi; Ferdinando Nicoletti; Mariapia Vairetti
Selective blockade of mGlu5 metabotropic glutamate receptors protects rat hepatocytes against hypoxic damage.
Hepatology (Baltimore, Md.) 2000;31(3):649-55.
1999: Agata Copani; Fabrizio Condorelli; A Caruso; Carlo Vancheri; A Sala; Anna Maria Giuffrida-Stella; Pier Luigi Canonico; Ferdinando Nicoletti; Maria Angela Sortino
Mitotic signaling by beta-amyloid causes neuronal death.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(15):2225-34.
1999: Ferdinando Nicoletti; Valeria Bruno; Maria Vincenza Catania; Giuseppe Battaglia; Agata Copani; Giuseppe M V Barbagallo; Valentín Ceña; J Sanchez-Prieto; PierFranco Spano; Marina Pizzi
Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection.
Neuropharmacology 1999;38(10):1477-84.
1999: Maria Vincenza Catania; Agata Copani; A Calogero; G I Ragonese; Daniele F Condorelli; Ferdinando Nicoletti
An enhanced expression of the immediate early gene, Egr-1, is associated with neuronal apoptosis in culture.
Neuroscience 1999;91(4):1529-38.
1998: Valeria Bruno; Giuseppe Battaglia; G Casabona; Agata Copani; Francesco Caciagli; Ferdinando Nicoletti
Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(23):9594-600.
1998: Vincenzo Giuseppe Nicoletti; Alessandra Caruso; Elisabetta A Tendi; Antonella Privitera; A Console; Vittorio Calabrese; F Spadaro; Agrippino Ravagna; Agata Copani; Anna Maria Giuffrida Stella
Effect of nitric oxide synthase induction on the expression of mitochondrial respiratory chain enzyme subunits in mixed cortical and astroglial cell cultures.
Biochimie 1998;80(10):871-81.
1998: Giuseppe Battaglia; Valeria Bruno; Richard Teke Ngomba; R Di Grezia; Agata Copani; Ferdinando Nicoletti
Selective activation of group-II metabotropic glutamate receptors is protective against excitotoxic neuronal death.
European journal of pharmacology 1998;356(2-3):271-4.
1998: Agata Copani; G Casabona; Valeria Bruno; Alessandra Caruso; Daniele F Condorelli; Angela Messina; Valeria Di Giorgi Gerevini; J P Pin; R Kuhn; T Knöpfel; Ferdinando Nicoletti
The metabotropic glutamate receptor mGlu5 controls the onset of developmental apoptosis in cultured cerebellar neurons.
The European journal of neuroscience 1998;10(6):2173-84.
1998: Valeria Bruno; Giuseppe Battaglia; Agata Copani; G Casabona; marianna storto; Valeria Di Giorgi Gerevini; Richard Teke Ngomba; Ferdinando Nicoletti
Metabotropic glutamate receptors and neurodegeneration.
Progress in brain research 1998;116():209-21.
1997: FX Sureda; Agata Copani; Valeria Bruno; T Knöpfel; G Meltzger; Ferdinando Nicoletti
Metabotropic glutamate receptor agonists stimulate polyphosphoinositide hydrolysis in primary cultures of rat hepatocytes.
European journal of pharmacology 1997;338(2):R1-2.
1997: G Casabona; T Knöpfel; R Kuhn; F Gasparini; P Baumann; Maria Angela Sortino; Agata Copani; Ferdinando Nicoletti
Expression and coupling to polyphosphoinositide hydrolysis of group I metabotropic glutamate receptors in early postnatal and adult rat brain.
The European journal of neuroscience 1997;9(1):12-7.
1996: Pier Luigi Canonico; Agata Copani; Velia D'Agata; S Musco; S Petralia; Salvatore Travali; Franca Stivala; Sebastiano Cavallaro
Activation of pituitary adenylate cyclase-activating polypeptide receptors prevents apoptotic cell death in cultured cerebellar granule cells.
Annals of the New York Academy of Sciences 1996;805():470-2.
1996: Maria Angela Sortino; G Aleppo; Agata Copani; G Casabona; Ferdinando Nicoletti; C Ventra; Rainer Kuhn; T Knöpfel; B Malitschek; Pier Luigi Canonico
Immortalized hypothalamic neurons express metabotropic glutamate receptors positively coupled to cyclic AMP formation.
The European journal of neuroscience 1996;8(11):2407-15.
1996: Valeria Bruno; Agata Copani; L Bonanno; T Knoepfel; R Kuhn; P J Roberts; F Nicoletti
Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures.
European journal of pharmacology 1996;310(1):61-6.
1996: L Bertino; M C Ruffini; Agata Copani; Valeria Bruno; G Raciti; A Cambria; Ferdinando Nicoletti
Growth conditions influence DNA methylation in cultured cerebellar granule cells.
Brain research. Developmental brain research 1996;95(1):38-43.
1996: Ferdinando Nicoletti; Valeria Bruno; Agata Copani; G Casabona; T Knöpfel
Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?
Trends in neurosciences 1996;19(7):267-71.
1996: Sebastiano Cavallaro; Agata Copani; Velia D'Agata; S Musco; S Petralia; C Ventra; Franca Stivala; Salvatore Travali; Pier Luigi Canonico
Pituitary adenylate cyclase activating polypeptide prevents apoptosis in cultured cerebellar granule neurons.
Molecular pharmacology 1996;50(1):60-6.
1996: Valeria Bruno; Agata Copani; Giuseppe Battaglia; Paola Dell'Albani; Daniele F Condorelli; Ferdinando Nicoletti
Metabotropic glutamate receptors and neuronal degeneration in culture.
Advances in neurology 1996;71():47-51, discussion 51-2.
1995: Valeria Bruno; Giuseppe Battaglia; Agata Copani; R G Giffard; G Raciti; Rocco Raffaele; H Shinozaki; Ferdinando Nicoletti
Activation of class II or III metabotropic glutamate receptors protects cultured cortical neurons against excitotoxic degeneration.
The European journal of neuroscience 1995;7(9):1906-13.
1995: Valeria Bruno; Agata Copani; T Knöpfel; Rainer Kuhn; G Casabona; Paola Dell'Albani; Daniele F Condorelli; Ferdinando Nicoletti
Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells.
Neuropharmacology 1995;34(8):1089-98.
1995: Agata Copani; Valeria Bruno; Giuseppe Battaglia; Giampiero Leanza; R Pellitteri; A Russo; Stefania Stanzani; Ferdinando Nicoletti
Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide.
Molecular pharmacology 1995;47(5):890-7.
1995: Agata Copani; Valeria Bruno; Paola Dell'Albani; Giuseppe Battaglia; Vincenza Barresi; Alessandra Caruso; Ferdinando Nicoletti; Daniele F Condorelli
Growth conditions differentially affect the constitutive expression of primary response genes in cultured cerebellar granule cells.
Neurochemical research 1995;20(5):611-6.
1995: Agata Copani; Valeria Bruno; Vincenza Barresi; Giuseppe Battaglia; Daniele F Condorelli; Ferdinando Nicoletti
Activation of metabotropic glutamate receptors prevents neuronal apoptosis in culture.
Journal of neurochemistry 1995;64(1):101-8.
1994: Valeria Bruno; Giuseppe Battaglia; Agata Copani; Maria Angela Sortino; Pier Luigi Canonico; Ferdinando Nicoletti
Protective action of idebenone against excitotoxic degeneration in cultured cortical neurons.
Neuroscience letters 1994;178(2):193-6.
1994: Valeria Bruno; Agata Copani; Giuseppe Battaglia; Rocco Raffaele; H Shinozaki; Ferdinando Nicoletti
Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death.
European journal of pharmacology 1994;256(1):109-12.
1993: D T Loo; Agata Copani; Christian J Pike; Edward R Whittemore; A J Walencewicz; Carl W Cotman
Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(17):7951-5.
1992: Carl W Cotman; Christian J Pike; Agata Copani
beta-Amyloid neurotoxicity: a discussion of in vitro findings.
Neurobiology of aging 1992;13(5):587-90.
1992: Ferdinando Nicoletti; G Casabona; Armando Genazzani; Agata Copani; G Aleppo; Pier Luigi Canonico; U Scapagnini
Excitatory amino acids and neuronal plasticity: modulation of AMPA receptors as a novel substrate for the action of nootropic drugs.
Functional neurology 1992;7(5):413-22.
1992: Agata Copani; Armando Genazzani; G Aleppo; G Casabona; Pier Luigi Canonico; U Scapagnini; Ferdinando Nicoletti
Nootropic drugs positively modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-sensitive glutamate receptors in neuronal cultures.
Journal of neurochemistry 1992;58(4):1199-204.
1992: G Aleppo; A Pisani; Agata Copani; Valeria Bruno; E Aronica; Velia D'Agata; Pier Luigi Canonico; Ferdinando Nicoletti
Metabotropic glutamate receptors and neuronal toxicity.
Advances in experimental medicine and biology 1992;318():137-45.
1991: Agata Copani; J Y Koh; Carl W Cotman
Beta-amyloid increases neuronal susceptibility to injury by glucose deprivation.
Neuroreport 1991;2(12):763-5.
1991: Agata Copani; G Raciti; Valeria Bruno; Maria Angela Sortino; Ferdinando Nicoletti; P L Canonico; A Cambria
Inositol hexakisphosphate stimulates 45Ca2+ influx in purified mitochondria from rat liver.
The Italian journal of biochemistry 1991;40(5):289-94.
1991: Agata Copani; Pier Luigi Canonico; Maria Vincenza Catania; E Aronica; Valeria Bruno; Emiliangelo Ratti; FT van Amsterdam; Giovanni Gaviraghi; Ferdinando Nicoletti
Interaction between beta-N-methylamino-L-alanine and excitatory amino acid receptors in brain slices and neuronal cultures.
Brain research 1991;558(1):79-86.
1991: Pier Luigi Canonico; E Aronica; G Aleppo; G Casabona; Agata Copani; A Favit; Ferdinando Nicoletti; U Scapagnini
Repeated injections of piracetam improve spatial learning and increase the stimulation of inositol phospholipid hydrolysis by excitatory amino acids in aged rats.
Functional neurology 1991;6(2):107-11.
1990: Agata Copani; Valeria Bruno; Sebastiano Cavallaro; L Fiore; Maria Angela Sortino; Pier Luigi Canonico; Ferdinando Nicoletti
Receptors for inositolhexakisphosphate in neurons and anterior pituitary cells.
Pharmacological research : the official journal of the Italian Pharmacological Society 1990;22 Suppl 1():83-4.
1990: Agata Copani; Pier Luigi Canonico; Ferdinando Nicoletti
Beta-N-methylamino-L-alanine (L-BMAA) is a potent agonist of 'metabolotropic' glutamate receptors.
European journal of pharmacology 1990;181(3):327-8.
1990: Ferdinando Nicoletti; Valeria Bruno; Sebastiano Cavallaro; Agata Copani; Maria Angela Sortino; Pier Luigi Canonico
Specific binding sites for inositolhexakisphosphate in brain and anterior pituitary.
Molecular pharmacology 1990;37(5):689-93.