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Shelley Copley

Research Profile

Chemicals & Drugs

Phenomena

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Living Beings

Physiology

Metabolic Networks and Pathways

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Publications

TOP 3
Juhan Kim; Shelley D Copley
The Orphan Protein Bis-γ-glutamylcystine Reductase Joins the Pyridine Nucleotide Disulfide Reductase Family.
Juhan Kim; Shelley D Copley
Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network.
Shelley D Copley
Moonlighting is mainstream: paradigm adjustment required.

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All Publications

2013: Juhan Kim; Shelley D Copley
The Orphan Protein Bis-γ-glutamylcystine Reductase Joins the Pyridine Nucleotide Disulfide Reductase Family.
Biochemistry 2013;52(17):2905-13.
2012: Juhan Kim; Shelley D Copley
Inhibitory cross-talk upon introduction of a new metabolic pathway into an existing metabolic network.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(42):E2856-64.
2012: Shelley D Copley
Moonlighting is mainstream: paradigm adjustment required.
BioEssays : news and reviews in molecular, cellular and developmental biology 2012;34(7):578-88.
2012: Klara Hlouchova; Jaana M H Pietari; Johannes Rudolph; Linda S Behlen; Shelley D Copley
Pentachlorophenol hydroxylase, a poorly functioning enzyme required for degradation of pentachlorophenol by Sphingobium chlorophenolicum.
Biochemistry 2012;51(18):3848-60.
2012: Shelley D Copley; Hajnalka Daligault; Matt Nolan; Joseph Rokicki; Pernilla Turner; Miriam Land
The whole genome sequence of Sphingobium chlorophenolicum L-1: insights into the evolution of the pentachlorophenol degradation pathway.
Genome biology and evolution 2012;4(2):184-98.
2011: Nataliya Chumachenko; Yehor Novikov; Richard K Shoemaker; Shelley D Copley
A dimethyl ketal-protected benzoin-based linker suitable for photolytic release of unprotected peptides.
The Journal of organic chemistry 2011;76(22):9409-16.
2010: Juhan Kim; Jamie P Kershner; Yehor Novikov; Richard K Shoemaker; Shelley D Copley
Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5'-phosphate synthesis.
Molecular systems biology 2010;6():436.
2009: Shelley D Copley
Evolution of efficient pathways for degradation of anthropogenic chemicals.
Nature chemical biology 2009;5(8):559-66.
2009: Shelley D Copley
Prediction of function in protein superfamilies.
F1000 biology reports 2009;1():91.
2008: Sean Yu McLoughlin; Shelley D Copley
A compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13497-502.
2008: Joseph R Warner; Linda S Behlen; Shelley D Copley
A trade-off between catalytic power and substrate inhibition in TCHQ dehalogenase.
Biochemistry 2008;47(10):3258-65.
2008: Micah Hamady; Jeremy Widmann; Shelley D Copley; Rob Knight
MotifCluster: an interactive online tool for clustering and visualizing sequences using shared motifs.
Genome biology 2008;9(8):R128.
2007: Shelley D Copley; Eric Smith; Harold J Morowitz
The origin of the RNA world: co-evolution of genes and metabolism.
Bioorganic chemistry 2007;35(6):430-43.
2007: Joseph R Warner; Shelley D Copley
Pre-steady-state kinetic studies of the reductive dehalogenation catalyzed by tetrachlorohydroquinone dehalogenase.
Biochemistry 2007;46(45):13211-22.
2007: Juhan Kim; Shelley D Copley
Why metabolic enzymes are essential or nonessential for growth of Escherichia coli K12 on glucose.
Biochemistry 2007;46(44):12501-11.
2007: Joseph R Warner; Shelley D Copley
Mechanism of the severe inhibition of tetrachlorohydroquinone dehalogenase by its aromatic substrates.
Biochemistry 2007;46(14):4438-47.
2005: Joseph R Warner; Sherry L Lawson; Shelley D Copley
A mechanistic investigation of the thiol-disulfide exchange step in the reductive dehalogenation catalyzed by tetrachlorohydroquinone dehalogenase.
Biochemistry 2005;44(30):10360-8.
2005: Shelley D Copley; Eric Smith; Harold J Morowitz
A mechanism for the association of amino acids with their codons and the origin of the genetic code.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4442-7.
2005: MingHua Dai; Sara Ziesman; Thomas Ratcliffe; Ryan T Gill; Shelley D Copley
Visualization of protoplast fusion and quantitation of recombination in fused protoplasts of auxotrophic strains of Escherichia coli.
Metabolic engineering 2005;7(1):45-52.
2004: Shelley D Copley; Walter R P Novak; Patricia C Babbitt
Divergence of function in the thioredoxin fold suprafamily: evidence for evolution of peroxiredoxins from a thioredoxin-like ancestor.
Biochemistry 2004;43(44):13981-95.
2004: MingHua Dai; Shelley D Copley
Genome shuffling improves degradation of the anthropogenic pesticide pentachlorophenol by Sphingobium chlorophenolicum ATCC 39723.
Applied and environmental microbiology 2004;70(4):2391-7.
2003: Shelley D Copley
Enzymes with extra talents: moonlighting functions and catalytic promiscuity.
Current opinion in chemical biology 2003;7(2):265-72.
2003: MingHua Dai; Julie Bull Rogers; Joseph R Warner; Shelley D Copley
A previously unrecognized step in pentachlorophenol degradation in Sphingobium chlorophenolicum is catalyzed by tetrachlorobenzoquinone reductase (PcpD).
Journal of bacteriology 2003;185(1):302-10.
2002: Philip M Kiefer; Shelley D Copley
Characterization of the initial steps in the reductive dehalogenation catalyzed by tetrachlorohydroquinone dehalogenase.
Biochemistry 2002;41(4):1315-22.
2002: Philip M Kiefer; Darla L McCarthy; Shelley D Copley
The reaction catalyzed by tetrachlorohydroquinone dehalogenase does not involve nucleophilic aromatic substitution.
Biochemistry 2002;41(4):1308-14.
2002: Shelley D Copley; Jasvinder Dhillon
Lateral gene transfer and parallel evolution in the history of glutathione biosynthesis genes.
Genome biology 2002;3(5):research0025.
2000: Shelley D Copley
Evolution of a metabolic pathway for degradation of a toxic xenobiotic: the patchwork approach.
Trends in biochemical sciences 2000;25(6):261-5.
2000: K Anandarajah; Philip M Kiefer; Bryon Donohoe; Shelley D Copley
Recruitment of a double bond isomerase to serve as a reductive dehalogenase during biodegradation of pentachlorophenol.
Biochemistry 2000;39(18):5303-11.
1999: L Xu; Katheryn A Resing; S L Lawson; Patricia C Babbitt; Shelley D Copley
Evidence that pcpA encodes 2,6-dichlorohydroquinone dioxygenase, the ring cleavage enzyme required for pentachlorophenol degradation in Sphingomonas chlorophenolica strain ATCC 39723.
Biochemistry 1999;38(24):7659-69.
1998: Shelley D Copley
Microbial dehalogenases: enzymes recruited to convert xenobiotic substrates.
Current opinion in chemical biology 1998;2(5):613-7.
1997: Darla L McCarthy; A A Claude; Shelley D Copley
In vivo levels of chlorinated hydroquinones in a pentachlorophenol-degrading bacterium.
Applied and environmental microbiology 1997;63(5):1883-8.
1996: D L McCarthy; S Navarrete; W S Willett; Patricia C Babbitt; Shelley D Copley
Exploration of the relationship between tetrachlorohydroquinone dehalogenase and the glutathione S-transferase superfamily.
Biochemistry 1996;35(46):14634-42.
1996: W S Willett; Shelley D Copley
Identification and localization of a stable sulfenic acid in peroxide-treated tetrachlorohydroquinone dehalogenase using electrospray mass spectrometry.
Chemistry & biology 1996;3(10):851-7.
1994: G P Crooks; Shelley D Copley
Purification and characterization of 4-chlorobenzoyl CoA dehalogenase from Arthrobacter sp. strain 4-CB1.
Biochemistry 1994;33(38):11645-9.
1992: Shelley D Copley; G P Crooks
Enzymic Dehalogenation of 4-Chlorobenzoyl Coenzyme A in Acinetobacter sp. Strain 4-CB1.
Applied and environmental microbiology 1992;58(4):1385-7.
1992: Shelley D Copley; E Frank; W M Kirsch; Tad H Koch
Detection and possible origins of aminomalonic acid in protein hydrolysates.
Analytical biochemistry 1992;201(1):152-7.