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Robert Allen

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Martha S Field; Olga V Malysheva; Kelsey S Shields; Sally P Stabler; Patrick J Stover; Barbara J Strupp; Elena V Abarinov; Robert H Allen; Jessica A Ash; Marie A Caudill
Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.
Hua Jiang; Robert H Allen; Sally P Stabler; Kenneth N Maclean
Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: possible implications for cardiovascular outcomes.
Anna E Beaudin; Cheryll A Perry; Sally P Stabler; Robert H Allen; Patrick J Stover
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.

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2013: Martha S Field; Olga V Malysheva; Kelsey S Shields; Sally P Stabler; Patrick J Stover; Barbara J Strupp; Elena V Abarinov; Robert H Allen; Jessica A Ash; Marie A Caudill
Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.
The Journal of nutrition 2013;143(1):41-5.
2012: Hua Jiang; Robert H Allen; Sally P Stabler; Kenneth N Maclean
Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: possible implications for cardiovascular outcomes.
Molecular genetics and metabolism 2012;107(1-2):55-65.
2012: Anna E Beaudin; Cheryll A Perry; Sally P Stabler; Robert H Allen; Patrick J Stover
Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice.
The American journal of clinical nutrition 2012;95(4):882-91.
2012: Kenneth N Maclean; Robert H Allen; Lori S Greiner; Hua Jiang; Sally P Stabler
Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.
Molecular genetics and metabolism 2012;105(3):395-403.
2012: S. Harvey Mudd; Richard Schroer; Sally P Stabler; Conrad Wagner; Jing Wang; Robert H Allen; Zigmund Luka; Timothy Wood; Lee-Jun Wong
Two patients with hepatic mtDNA depletion syndromes and marked elevations of S-adenosylmethionine and methionine.
Molecular genetics and metabolism 2012;105(2):228-36.
2011: Edith D Gurewitsch; Robert H Allen
Reducing the risk of shoulder dystocia and associated brachial plexus injury.
Obstetrics and gynecology clinics of North America 2011;38(2):247-69, x.
2011: Kristy A Ruis; Robert H Allen; Edith D Gurewitsch
Severe shoulder dystocia with a small-for-gestationaI-age infant: a case report.
The Journal of reproductive medicine 2011;56(3-4):178-80.
2011: Sally Stabler; Conrad Wagner; Zhiguo Zhao; Robert H Allen; Peter E Clark; Tatsuki Koyama; Lioudmila V Loukachevitch; Zigmund Luka; Magaly Martinez-Ferrer; Neil A Bhowmick
Serum methionine metabolites are risk factors for metastatic prostate cancer progression.
PloS one 2011;6(8):e22486.
2010: Kenneth N Maclean; Jakub Sikora; Viktor Kožich; Hua Jiang; Lori S Greiner; Eva Kraus; Jakub Krijt; Linda S Crnic; Robert H Allen; Sally P Stabler; Milan Elleder; Jan P Kraus
Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment.
Molecular genetics and metabolism 2010;101(2-3):163-71.
2010: Kenneth N Maclean; Jakub Sikora; Viktor Kožich; Hua Jiang; Lori S Greiner; Eva Kraus; Jakub Krijt; Katherine H Overdier; Renata Collard; Gary L Brodsky; Lynne Meltesen; Linda S Crnic; Robert H Allen; Sally P Stabler; Milan Elleder; Rima Rozen; David Patterson; Jan P Kraus
A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment.
Molecular genetics and metabolism 2010;101(2-3):153-62.
2010: A M Matteini; Jeremy Walston; Karen Bandeen-Roche; Dan E Arking; Robert H Allen; Linda P Fried; Aravinda Chakravarti; S P Stabler; MARGARET D FALLIN
Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty.
The journal of nutrition, health & aging 2010;14(1):73-7.
2009: Sally P Stabler; Jeevan Sekhar; Robert H Allen; Heidi C O'Neill; Carl W White
Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine.
Free radical biology & medicine 2009;47(8):1147-53.
2009: Jan P Kraus; Jindrich Hasek; Viktor Kozich; Renata Collard; Sarah Venezia; Bohumila Janosíková; Jian Wang; Sally P Stabler; Robert H Allen; Cornelis Jakobs; Christine T Finn; Yin-Hsiu Chien; Wuh-Liang Hwu; Robert A Hegele; S Harvey Mudd
Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies.
Molecular genetics and metabolism 2009;97(4):250-9.
2009: Mihalis I Panayiotidis; Sally P Stabler; Robert H Allen; Aglaia Pappa; Carl W White
Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells.
Mutation research 2009;674(1-2):23-30.
2008: Robert H Allen; Sally P Stabler
Identification and quantitation of cobalamin and cobalamin analogues in human feces.
The American journal of clinical nutrition 2008;87(5):1324-35.
2008: A M Matteini; Jeremy Walston; MARGARET D FALLIN; Karen Bandeen-Roche; WEN KAO; Richard D Semba; Robert H Allen; Jack M Guralnik; Linda P Fried; S P Stabler
Markers of B-vitamin deficiency and frailty in older women.
The journal of nutrition, health & aging 2008;12(5):303-8.
2007: Kevin A Strauss; D Holmes Morton; Erik G Puffenberger; Christine Hendrickson; Donna L Robinson; Conrad Wagner; Sally P Stabler; Robert H Allen; Grazyna Chwatko; Hieronim Jakubowski; Mihai D Niculescu; S Harvey Mudd
Prevention of brain disease from severe 5,10-methylenetetrahydrofolate reductase deficiency.
Molecular genetics and metabolism 2007;91(2):165-75.
2007: S Harvey Mudd; John T Brosnan; Margaret E Brosnan; René L Jacobs; Sally P Stabler; Robert H Allen; Dennis E Vance; Conrad Wagner
Methyl balance and transmethylation fluxes in humans.
The American journal of clinical nutrition 2007;85(1):19-25.
2006: Sally P Stabler; Robert H Allen; Evi T Dolce; Mary Ann Johnson
Elevated serum S-adenosylhomocysteine in cobalamin-deficient elderly and response to treatment.
The American journal of clinical nutrition 2006;84(6):1422-9.
2006: N R M Buist; Byron Glenn; Oliver Vugrek; Conrad Wagner; Sally P Stabler; Robert H Allen; Igor P Pogribny; Andreas Schulze; Steven H Zeisel; I Barić; S Harvey Mudd
S-adenosylhomocysteine hydrolase deficiency in a 26-year-old man.
Journal of inherited metabolic disease 2006;29(4):538-45.
2006: Mihalis I Panayiotidis; Sally P Stabler; Aftab Ahmad; Aglaia Pappa; Leighton H Legros; Daniel Hernandez-Saavedra; Barbara K Schneider; Robert H Allen; Vasilis Vasiliou; Joe M McCord; Malak Kotb; Carl W White
Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia.
Free radical biology & medicine 2006;40(2):348-58.
2005: Clinton Wright; Myunghee C Paik; Truman R Brown; Sally P Stabler; Robert H Allen; Ralph L Sacco; Charles DeCarli
Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study.
Stroke; a journal of cerebral circulation 2005;36(6):1207-11.
2005: I Barić; Mario Cuk; K Fumić; Oliver Vugrek; Robert H Allen; Byron Glenn; Miljenka Maradin; Leo Pazanin; Igor P Pogribny; Marko Rados; Vladimir Sarnavka; Andreas Schulze; Sally P Stabler; Conrad Wagner; Steven H Zeisel; S Harvey Mudd
S-Adenosylhomocysteine hydrolase deficiency: a second patient, the younger brother of the index patient, and outcomes during therapy.
Journal of inherited metabolic disease 2005;28(6):885-902.
2004: Clinton Wright; H-S Lee; Myunghee C Paik; Sally P Stabler; Robert H Allen; Ralph L Sacco
Total homocysteine and cognition in a tri-ethnic cohort: the Northern Manhattan Study.
Neurology 2004;63(2):254-60.
2004: Ivo Baric; Ksenija Fumic; Byron Glenn; Mario Cuk; Andreas Schulze; James D Finkelstein; S Jill James; Vlatka Mejaski-Bosnjak; Leo Pazanin; Igor P Pogribny; Marko Rados; Vladimir Sarnavka; Mira Scukanec-Spoljar; Robert H Allen; Sally P Stabler; Lidija Uzelac; Oliver Vugrek; Conrad Wagner; Steven H Zeisel; S Harvey Mudd
S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(12):4234-9.
2004: Sally P Stabler; Robert H Allen
Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry.
Clinical chemistry 2004;50(2):365-72.
2004: Mihalis I Panayiotidis; Sally P Stabler; Robert H Allen; Aftab Ahmad; Carl W White
Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells.
Chemico-biological interactions 2004;147(1):87-97.
2004: Robert H Allen; William Tam; Artin A Shoukas
Empowering biomedical engineering undergraduates to help teach design.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2004;7():5154-7.
2004: Sally P Stabler; Robert H Allen
Vitamin B12 deficiency as a worldwide problem.
Annual review of nutrition 2004;24():299-326.
2003: S Harvey Mudd; Nancy Braverman; Martin G Pomper; Kamer Tezcan; Jonathan Kronick; Parul Jayakar; Cheryl Garganta; Mary G Ampola; Harvey L Levy; Shawn E McCandless; Hobart Wiltse; Sally P Stabler; Robert H Allen; Conrad Wagner; Marlene W Borschel
Infantile hypermethioninemia and hyperhomocysteinemia due to high methionine intake: a diagnostic trap.
Molecular genetics and metabolism 2003;79(1):6-16.
2003: P Augoustides-Savvopoulou; Zigmund Luka; Stavroula Karyda; Sally P Stabler; Robert H Allen; Kalliopi Patsiaoura; Conrad Wagner; S Harvey Mudd
Glycine N -methyltransferase deficiency: a new patient with a novel mutation.
Journal of inherited metabolic disease 2003;26(8):745-59.
2003: S Harvey Mudd; Albert Tangerman; Sally P Stabler; Robert H Allen; Conrad Wagner; Steven H Zeisel; Harvey L Levy
Maternal methionine adenosyltransferase I/III deficiency: reproductive outcomes in a woman with four pregnancies.
Journal of inherited metabolic disease 2003;26(5):443-58.
2002: Sally P Stabler; Clemens Steegborn; Markus C Wahl; Jana Oliveriusova; Jan P Kraus; Robert H Allen; Conrad Wagner; S Harvey Mudd
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency.
Metabolism: clinical and experimental 2002;51(8):981-8.
2002: E M Cottington; Christian LaMantia; Sally P Stabler; Robert H Allen; Albert Tangerman; Conrad Wagner; Steven H Zeisel; S Harvey Mudd
Adverse event associated with methionine loading test: a case report.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(6):1046-50.
2002: Reza Yaghmai; Amir H Kashani; Michael T Geraghty; Jay Okoh; Martin G Pomper; Albert Tangerman; Conrad Wagner; Sally P Stabler; Robert H Allen; S Harvey Mudd; Nancy Braverman
Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine beta-synthase (CBS) deficiency.
American journal of medical genetics 2002;108(1):57-63.
2001: S Harvey Mudd; Roberto Cerone; Maria Cristina Schiaffino; AR Fantasia; Giuseppe Minniti; Ubaldo Caruso; R Lorini; D Watkins; NV Matiaszuk; David S Rosenblatt; B Schwahn; R Rozen; Leighton H Legros; Malak Kotb; Antonieta Capdevila; Zigmund Luka; James D Finkelstein; Albert Tangerman; Sally P Stabler; Robert H Allen; Conrad Wagner
Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia.
Journal of inherited metabolic disease 2001;24(4):448-64.
2001: Robert H Allen; Carolyn Westhoff; LJ De Nonno; Stephen L Fielding; Eric A Schaff
Curettage after mifepristone-induced abortion: frequency, timing, and indications.
Obstetrics and gynecology 2001;98(1):101-6.
2000: Sally P Stabler; ronald lee morton; Shannon L Winski; Robert H Allen; Carl W White
Effects of parenteral cysteine and glutathione feeding in a baboon model of severe prematurity.
The American journal of clinical nutrition 2000;72(6):1548-57.
2000: S Harvey Mudd; James D Finkelstein; H Refsum; Per Magne Ueland; M Rene Malinow; Steven R Lentz; D W Jacobsen; L Brattström; B Wilcken; DE Wilcken; H J Blom; Sally P Stabler; Robert H Allen; J Selhub; I H Rosenberg
Homocysteine and its disulfide derivatives: a suggested consensus terminology.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(7):1704-6.
2000: David G Savage; A Ogundipe; Robert H Allen; Sally P Stabler; J Lindenbaum
Etiology and diagnostic evaluation of macrocytosis.
The American journal of the medical sciences 2000;319(6):343-52.
1999: Sally P Stabler; Robert H Allen; Linda P Fried; M Pahor; Steven Kittner; B W Penninx; J M Guralnik
Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women.
The American journal of clinical nutrition 1999;70(5):911-9.
1999: Sally P Stabler; Raymond O Estacio; BW Jeffers; J A Cohen; Robert H Allen; Robert W Schrier
Total homocysteine is associated with nephropathy in non-insulin-dependent diabetes mellitus.
Metabolism: clinical and experimental 1999;48(9):1096-101.
1999: David G Savage; Robert H Allen; Innocent T Gangaidzo; LM Levy; C Gwanzura; A Moyo; Boniface Mudenge; CF Kiire; Joshua M Mukiibi; Sally P Stabler; J Lindenbaum
Pancytopenia in Zimbabwe.
The American journal of the medical sciences 1999;317(1):22-32.
1998: A M Kuzminski; E J Del Giacco; Robert H Allen; Sally P Stabler; J Lindenbaum
Effective treatment of cobalamin deficiency with oral cobalamin.
Blood 1998;92(4):1191-8.
1998: E Susser; Alan S Brown; E Klonowski; Robert H Allen; J Lindenbaum
Schizophrenia and impaired homocysteine metabolism: a possible association.
Biological psychiatry 1998;44(2):141-3.
1998: Robert H Allen; Sally P Stabler; J Lindenbaum
Relevance of vitamins, homocysteine and other metabolites in neuropsychiatric disorders.
European journal of pediatrics 1998;157 Suppl 2():S122-6.
1997: Sally P Stabler; J Lindenbaum; Robert H Allen
Vitamin B-12 deficiency in the elderly: current dilemmas.
The American journal of clinical nutrition 1997;66(4):741-9.
1997: Giuseppe Scalabrino; Francesca R Buccellato; Giovanni Tredici; Alberto Morabito; Evelina Lorenzini; Robert H Allen; J Lindenbaum
Enhanced levels of biochemical markers for cobalamin deficiency in totally gastrectomized rats: uncoupling of the enhancement from the severity of spongy vacuolation in spinal cord.
Experimental neurology 1997;144(2):258-65.
1996: Sally P Stabler; J Lindenbaum; Robert H Allen
The use of homocysteine and other metabolites in the specific diagnosis of vitamin B-12 deficiency.
The Journal of nutrition 1996;126(4 Suppl):1266S-72S.
1996: Robert H Allen; J Lindenbaum; Sally P Stabler
High prevalence of cobalamin deficiency in the elderly.
Transactions of the American Clinical and Climatological Association 1996;107():37-45; discussion 45-7.
1995: J Lindenbaum; E B Healton; David G Savage; John C M Brust; Thomas J Garrett; E R Podell; P D Marcell; Sally P Stabler; Robert H Allen
Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. 1988.
Nutrition (Burbank, Los Angeles County, Calif.) 1995;11(2):181; discussion 180, 182.
1994: J Lindenbaum; I H Rosenberg; P W Wilson; Sally P Stabler; Robert H Allen
Prevalence of cobalamin deficiency in the Framingham elderly population.
The American journal of clinical nutrition 1994;60(1):2-11.
1993: Robert H Allen; Sally P Stabler; David G Savage; J Lindenbaum
Metabolic abnormalities in cobalamin (vitamin B12) and folate deficiency.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(14):1344-53.
1993: Robert H Allen; Sally P Stabler; J Lindenbaum
Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism.
Metabolism: clinical and experimental 1993;42(11):1448-60.
1993: Robert H Allen; Sally P Stabler; David G Savage; J Lindenbaum
Elevation of 2-methylcitric acid I and II levels in serum, urine, and cerebrospinal fluid of patients with cobalamin deficiency.
Metabolism: clinical and experimental 1993;42(8):978-88.
1993: Sally P Stabler; J Lindenbaum; David G Savage; Robert H Allen
Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency.
Blood 1993;81(12):3404-13.
1993: J Fred Kolhouse; Sally P Stabler; Robert H Allen
Identification and perturbation of mutant human fibroblasts based on measurements of methylmalonic acid and total homocysteine in the culture media.
Archives of biochemistry and biophysics 1993;303(2):355-60.
1992: D P Sundin; Robert H Allen
Analysis of the nucleoside moiety of cobalamin and cobalamin analogues using gas chromatography-mass spectrometry.
Archives of biochemistry and biophysics 1992;298(2):658-66.
1992: Robert H Allen; Sally P Stabler; David G Savage; J Lindenbaum
New approaches to the diagnosis of cobalamin (Cbl, vitamin B12) deficiency in neuropsychiatric disorders.
Journal of nutritional science and vitaminology 1992;Spec No():130-3.
1991: J Fred Kolhouse; C Utley; Sally P Stabler; Robert H Allen
Mechanism of conversion of human apo- to holomethionine synthase by various forms of cobalamin.
The Journal of biological chemistry 1991;266(34):23010-5.
1991: Sally P Stabler; Robert H Allen; R E Barrett; David G Savage; J Lindenbaum
Cerebrospinal fluid methylmalonic acid levels in normal subjects and patients with cobalamin deficiency.
Neurology 1991;41(10):1627-32.
1991: Sally P Stabler; E P Brass; P D Marcell; Robert H Allen
Inhibition of cobalamin-dependent enzymes by cobalamin analogues in rats.
The Journal of clinical investigation 1991;87(4):1422-30.
1990: Sally P Stabler; Robert H Allen; David G Savage; J Lindenbaum
Clinical spectrum and diagnosis of cobalamin deficiency.
Blood 1990;76(5):871-81.
1990: J Lindenbaum; David G Savage; Sally P Stabler; Robert H Allen
Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations.
American journal of hematology 1990;34(2):99-107.
1990: Robert H Allen; Sally P Stabler; David G Savage; J Lindenbaum
Diagnosis of cobalamin deficiency I: usefulness of serum methylmalonic acid and total homocysteine concentrations.
American journal of hematology 1990;34(2):90-8.
1990: E P Brass; Robert H Allen; L J Ruff; Sally P Stabler
Effect of hydroxycobalamin[c-lactam] on propionate and carnitine metabolism in the rat.
The Biochemical journal 1990;266(3):809-15.
1990: E P Brass; A G Tahiliani; Robert H Allen; Sally P Stabler
Coenzyme A metabolism in vitamin B-12-deficient rats.
The Journal of nutrition 1990;120(3):290-7.
1988: P C Elwood; W K Reid; P D Marcell; Robert H Allen; J Fred Kolhouse
Determination of the carbohydrate composition of mammalian glycoproteins by capillary gas chromatography/mass spectrometry.
Analytical biochemistry 1988;175(1):202-11.
1988: J Lindenbaum; E B Healton; David G Savage; John C M Brust; Thomas J Garrett; E R Podell; P D Marcell; Sally P Stabler; Robert H Allen
Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis.
The New England journal of medicine 1988;318(26):1720-8.
1988: Sally P Stabler; J Lindenbaum; Robert H Allen
Failure to detect beta-leucine in human blood or leucine 2,3-aminomutase in rat liver using capillary gas chromatography-mass spectrometry.
The Journal of biological chemistry 1988;263(12):5581-8.
1988: Sally P Stabler; P D Marcell; E R Podell; Robert H Allen; David G Savage; J Lindenbaum
Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry.
The Journal of clinical investigation 1988;81(2):466-74.
1987: Sally P Stabler; P D Marcell; E R Podell; Robert H Allen
Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry.
Analytical biochemistry 1987;162(1):185-96.
1986: Sally P Stabler; P D Marcell; E R Podell; Robert H Allen; J Lindenbaum
Assay of methylmalonic acid in the serum of patients with cobalamin deficiency using capillary gas chromatography-mass spectrometry.
The Journal of clinical investigation 1986;77(5):1606-12.
1985: C S Utley; P D Marcell; Robert H Allen; A C Antony; J Fred Kolhouse
Isolation and characterization of methionine synthetase from human placenta.
The Journal of biological chemistry 1985;260(25):13656-65.
1985: P D Marcell; Sally P Stabler; E R Podell; Robert H Allen
Quantitation of methylmalonic acid and other dicarboxylic acids in normal serum and urine using capillary gas chromatography-mass spectrometry.
Analytical biochemistry 1985;150(1):58-66.
1985: Sally P Stabler; P D Marcell; Robert H Allen
Isolation and characterization of DL-methylmalonyl-coenzyme A racemase from rat liver.
Archives of biochemistry and biophysics 1985;241(1):252-64.
1981: H Kondo; Molly L Osborne; J Fred Kolhouse; M J Binder; E R Podell; C S Utley; R S Abrams; Robert H Allen
Nitrous oxide has multiple deleterious effects on cobalamin metabolism and causes decreases in activities of both mammalian cobalamin-dependent enzymes in rats.
The Journal of clinical investigation 1981;67(5):1270-83.
1980: J Fred Kolhouse; C Utley; Robert H Allen
Isolation and characterization of methylmalonyl-CoA mutase from human placenta.
The Journal of biological chemistry 1980;255(7):2708-12.