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Laura Corral

Research Profile

Chemicals & Drugs

Physiology

Disorders

Anemia, Sickle Cell

Anatomy

Living Beings

HIV-1
Mouse

Concepts & Ideas

Structure-Activity Relationship

Co-author Network

Publications

TOP 3
Alexander L Ruchelman; Peter H Schafer; Michael A Shirley; Yang Tang; Weihong Zhang; Anastasia Parton; Darius Babusis; Lori Capone; Roger Chen; Laura G Corral; Jian Kang; Hon-Wah Man; Mehran F Moghaddam; George W Muller
Isosteric analogs of lenalidomide and pomalidomide: synthesis and biological activity.
Steffen E. Meiler; Laure A Moutouh-de Parseval; Paul Steven Swerdlow; Marlene Wade; Yongjun Xue; Shobha D Yerigenahally; Laura G Corral; Ferdane Kutlar; Abdullah Kutlar
Pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice.
Laure Moutouh-de Parseval; Dominique Verhelle; Emilia Glezer; Kristen Jensen-Pergakes; Gregory D Ferguson; Laura G Corral; Christopher L Morris; George Muller; Helen Brady; Kyle Chan
Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells.

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All Publications

2013: Alexander L Ruchelman; Peter H Schafer; Michael A Shirley; Yang Tang; Weihong Zhang; Anastasia Parton; Darius Babusis; Lori Capone; Roger Chen; Laura G Corral; Jian Kang; Hon-Wah Man; Mehran F Moghaddam; George W Muller
Isosteric analogs of lenalidomide and pomalidomide: synthesis and biological activity.
Bioorganic & medicinal chemistry letters 2013;23(1):360-5.
2011: Steffen E. Meiler; Laure A Moutouh-de Parseval; Paul Steven Swerdlow; Marlene Wade; Yongjun Xue; Shobha D Yerigenahally; Laura G Corral; Ferdane Kutlar; Abdullah Kutlar
Pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice.
Blood 2011;118(4):1109-12.
2008: Laure Moutouh-de Parseval; Dominique Verhelle; Emilia Glezer; Kristen Jensen-Pergakes; Gregory D Ferguson; Laura G Corral; Christopher L Morris; George Muller; Helen Brady; Kyle Chan
Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells.
The Journal of clinical investigation 2008;118(1):248-58.
2007: Gregory D Ferguson; Kristen Jensen-Pergakes; Candice Wilkey; Urvi Jhaveri; Normand Richard; Dominique Verhelle; Laure Moutouh De Parseval; Laura G Corral; Weilin Xie; Christopher L Morris; Helen Brady; Kyle Chan
Immunomodulatory drug CC-4047 is a cell-type and stimulus-selective transcriptional inhibitor of cyclooxygenase 2.
Journal of clinical immunology 2007;27(2):210-20.
2007: Dominique Verhelle; Laura G Corral; Kevin Wong; Jessica H Mueller; Laure Moutouh-de Parseval; Kristen Jensen-Pergakes; Peter H Schafer; Roger Chen; Emilia Glezer; Gregory D Ferguson; Antonia Lopez-Girona; George W Muller; Helen A Brady; Kyle W H Chan
Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells.
Cancer research 2007;67(2):746-55.
2006: Ling-Hua Zhang; Lei Wu; Heather K Raymon; Roger S Chen; Laura G Corral; Michael A Shirley; Rama Krishna Narla; Jim Gamez; George W Muller; David I Stirling; J Blake Bartlett; Peter H Schafer; Faribourz Payvandi
The synthetic compound CC-5079 is a potent inhibitor of tubulin polymerization and tumor necrosis factor-alpha production with antitumor activity.
Cancer research 2006;66(2):951-9.
2003: Hon-Wah Man; Laura G Corral; David I Stirling; George W Muller
Alpha-fluoro-substituted thalidomide analogues.
Bioorganic & medicinal chemistry letters 2003;13(20):3415-7.
2003: Peter H Schafer; Anita K Gandhi; Michelle A Loveland; Roger S Chen; Hon-Wah Man; Paul P M Schnetkamp; Gregor Wolbring; Sowmya Govinda; Laura G Corral; Faribourz Payvandi; George W Muller; David I Stirling
Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1222-32.
1999: Stephen J Oliver; S L Freeman; Laura G Corral; C J Ocampo; Gilla Kaplan
Thalidomide analogue CC1069 inhibits development of rat adjuvant arthritis.
Clinical and experimental immunology 1999;118(2):315-21.
1999: Patrick A J Haslett; J D Klausner; Sanit Makonkawkeyoon; A Moreira; P Metatratip; B Boyle; warunee kunachiwa; Niwat Maneekarn; P Vongchan; Laura G Corral; T Elbeik; Z Shen; Gilla Kaplan
Thalidomide stimulates T cell responses and interleukin 12 production in HIV-infected patients.
AIDS research and human retroviruses 1999;15(13):1169-79.
1999: Laura G Corral; Patrick A J Haslett; George W Muller; Roger Chen; LM Wong; C J Ocampo; RT Patterson; David I Stirling; Gilla Kaplan
Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):380-6.
1999: George W Muller; Roger Chen; S Y Huang; Laura G Corral; LM Wong; RT Patterson; Y Chen; Gilla Kaplan; David I Stirling
Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production.
Bioorganic & medicinal chemistry letters 1999;9(11):1625-30.
1998: George W Muller; M G Shire; LM Wong; Laura G Corral; RT Patterson; Y Chen; David I Stirling
Thalidomide analogs and PDE4 inhibition.
Bioorganic & medicinal chemistry letters 1998;8(19):2669-74.
1998: Patrick A J Haslett; Laura G Corral; M Albert; Gilla Kaplan
Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subset.
The Journal of experimental medicine 1998;187(11):1885-92.
1997: Andre L Moreira; Laura G Corral; W Ye; B Johnson; David Stirling; George W Muller; Victoria Freedman; Gilla Kaplan
Thalidomide and thalidomide analogs reduce HIV type 1 replication in human macrophages in vitro.
AIDS research and human retroviruses 1997;13(10):857-63.
1996: George W Muller; Laura G Corral; M G Shire; H Wang; A Moreira; Gilla Kaplan; D I Stirling
Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity.
Journal of medicinal chemistry 1996;39(17):3238-40.
1996: Laura G Corral; George W Muller; Andre L Moreira; Y Chen; M Wu; D Stirling; Gilla Kaplan
Selection of novel analogs of thalidomide with enhanced tumor necrosis factor alpha inhibitory activity.
Molecular medicine (Cambridge, Mass.) 1996;2(4):506-15.
1996: J D Klausner; S Makonkawkeyoon; P Akarasewi; K Nakata; Watchara Kasinrerk; Laura G Corral; R L Dewar; H Clifford Lane; Victoria Freedman; Gilla Kaplan
The effect of thalidomide on the pathogenesis of human immunodeficiency virus type 1 and M. tuberculosis infection.
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association 1996;11(3):247-57.
1995: B J Johnson; S R Ress; P Willcox; B P Pati; F Lorgat; P Stead; R Saha; P Lukey; P Laochumroonvorapong; Laura G Corral
Clinical and immune responses of tuberculosis patients treated with low-dose IL-2 and multidrug therapy.
Cytokines and molecular therapy 1995;1(3):185-96.