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Blaise Corthésy

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Gilles Bioley; Anne Lassus; Jacques Terrettaz; François Tranquart; Dietmar Zehn; Blaise Corthésy
The effect of vaccines based on ovalbumin coupled to gas-filled microbubbles for reducing infection by ovalbumin-expressing Listeria monocytogenes.
Blaise Corthésy
Role of secretory IgA in infection and maintenance of homeostasis.
Stéphanie Longet; Marius Lötscher; Sylvia M Miescher; Sarah Miled; Adrian Zuercher; Blaise Corthésy
Human plasma-derived polymeric IgA and IgM antibodies associate with secretory component to yield biologically active secretory-like antibodies.

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All Publications

2013: Gilles Bioley; Anne Lassus; Jacques Terrettaz; François Tranquart; Dietmar Zehn; Blaise Corthésy
The effect of vaccines based on ovalbumin coupled to gas-filled microbubbles for reducing infection by ovalbumin-expressing Listeria monocytogenes.
Biomaterials 2013;34(21):5423-30.
2013: Blaise Corthésy
Role of secretory IgA in infection and maintenance of homeostasis.
Autoimmunity reviews 2013;12(6):661-5.
2013: Stéphanie Longet; Marius Lötscher; Sylvia M Miescher; Sarah Miled; Adrian Zuercher; Blaise Corthésy
Human plasma-derived polymeric IgA and IgM antibodies associate with secretory component to yield biologically active secretory-like antibodies.
The Journal of biological chemistry 2013;288(6):4085-94.
2012: Nicolas Rol; Laurent Favre; Jalil Benyacoub; Blaise Corthésy
The role of secretory immunoglobulin A in the natural sensing of commensal bacteria by mouse Peyer's patch dendritic cells.
The Journal of biological chemistry 2012;287(47):40074-82.
2012: Gilles Bioley; Philippe Bussat; Anne Lassus; Jacques Terrettaz; François Tranquart; Blaise Corthésy
Gas-filled microbubble-mediated delivery of antigen and the induction of immune responses.
Biomaterials 2012;33(25):5935-46.
2012: Annina M Hafner; Daniel Burschowsky; Blaise Corthésy; Marcus Textor; Hans P Merkle
Surface assembly of poly(I:C) on PEGylated microspheres to shield from adverse interactions with fibroblasts.
Journal of controlled release : official journal of the Controlled Release Society 2012;159(2):204-14.
2012: Céline Pellaton; Anne-Christine Thierry; Nathalie Barbier; Carine Blanchard; Caroline Boudousquié; Blaise Corthésy; Annick Mercenier; Sophie Nutten; François Spertini
Intragastric and Intranasal Administration of Lactobacillus paracasei NCC2461 Modulates Allergic Airway Inflammation in Mice.
International journal of inflammation 2012;2012():686739.
2012: Gilles Bioley; Philippe Bussat; Anne Lassus; Michel Schneider; Jacques Terrettaz; Blaise Corthésy
The phagocytosis of gas-filled microbubbles by human and murine antigen-presenting cells.
Biomaterials 2012;33(1):333-42.
2011: Amandine Mathias; Blaise Corthésy
N-Glycans on secretory component: mediators of the interaction between secretory IgA and gram-positive commensals sustaining intestinal homeostasis.
Gut microbes 2011;2(5):287-93.
2011: Amandine Mathias; Blaise Corthésy
Recognition of gram-positive intestinal bacteria by hybridoma- and colostrum-derived secretory immunoglobulin A is mediated by carbohydrates.
The Journal of biological chemistry 2011;286(19):17239-47.
2011: Martin Blüggel; François Spertini; Petra Lutter; Jacqueline Wassenberg; Régine Audran; Blaise Corthésy; Stefan Müllner; Stephanie Blum; Andreas Wattenberg; Annick Mercenier; Michael Affolter; Martin Kussmann
Toward protein biomarkers for allergy: CD4+ T cell proteomics in allergic and nonallergic subjects sampled in and out of pollen season.
Journal of proteome research 2011;10(4):1558-70.
2011: Annina M Hafner; Blaise Corthésy; Marcus Textor; Hans P Merkle
Tuning the immune response of dendritic cells to surface-assembled poly(I:C) on microspheres through synergistic interactions between phagocytic and TLR3 signaling.
Biomaterials 2011;32(10):2651-61.
2011: Stephen J Forbes; Tia Bumpus; Elizabeth A McCarthy; Blaise Corthésy; Nicholas J Mantis
Transient suppression of Shigella flexneri type 3 secretion by a protective O-antigen-specific monoclonal IgA.
mBio 2011;2(3):e00042-11.
2010: Amandine Mathias; Mélanie Duc; Laurent Favre; Jalil Benyacoub; Stephanie Blum; Blaise Corthésy
Potentiation of polarized intestinal Caco-2 cell responsiveness to probiotics complexed with secretory IgA.
The Journal of biological chemistry 2010;285(44):33906-13.
2010: Loane Decrausaz; Véronique Revaz; Martine Bobst; Blaise Corthésy; Pedro Romero; Denise Nardelli-Haefliger
Induction of human papillomavirus oncogene-specific CD8 T-cell effector responses in the genital mucosa of vaccinated mice.
International journal of cancer. Journal international du cancer 2010;126(10):2469-78.
2010: Blaise Corthésy
Role of secretory immunoglobulin A and secretory component in the protection of mucosal surfaces.
Future microbiology 2010;5(5):817-29.
2010: Sophie Duchez; Rada Amin; Nadine Cogné; Laurent Delpy; Christophe Sirac; Virginie Pascal; Blaise Corthésy; Michel Cogné
Premature replacement of mu with alpha immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):3064-9.
2010: Mélanie Duc; Finn-Eirik Johansen; Blaise Corthésy
Antigen binding to secretory immunoglobulin A results in decreased sensitivity to intestinal proteases and increased binding to cellular Fc receptors.
The Journal of biological chemistry 2010;285(2):953-60.
2010: Clémentine Perrier; A-C Thierry; Annick Mercenier; Blaise Corthésy
Allergen-specific antibody and cytokine responses, mast cell reactivity and intestinal permeability upon oral challenge of sensitized and tolerized mice.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2010;40(1):153-62.
2009: Séverine Boullier; Myriam Tanguy; Khalil A Kadaoui; Cécile Caubet; Philippe Sansonetti; Blaise Corthésy; Armelle Phalipon
Secretory IgA-mediated neutralization of Shigella flexneri prevents intestinal tissue destruction by down-regulating inflammatory circuits.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(9):5879-85.
2009: A-C Thierry; Enos Bernasconi; Annick Mercenier; Blaise Corthésy
Conditioned polarized Caco-2 cell monolayers allow to discriminate for the ability of gut-derived microorganisms to modulate permeability and antigen-induced basophil degranulation.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2009;39(4):527-36.
2007: Khalil A Kadaoui; Blaise Corthésy
Secretory IgA mediates bacterial translocation to dendritic cells in mouse Peyer's patches with restriction to mucosal compartment.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7751-7.
2007: Nicholas J Mantis; Jana Palaia; Ann J Hessell; Simren Mehta; Zhiyi Zhu; Blaise Corthésy; Marian R Neutra; Dennis R Burton; Edward janoff
Inhibition of HIV-1 infectivity and epithelial cell transfer by human monoclonal IgG and IgA antibodies carrying the b12 V region.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(5):3144-52.
2007: Alexandra Bonner; Clémentine Perrier; Blaise Corthésy; Stephen J Perkins
Solution structure of human secretory component and implications for biological function.
The Journal of biological chemistry 2007;282(23):16969-80.
2007: Claudine Fasching; Tracy Grossman; Blaise Corthésy; Andrew G Plaut; Jeffrey N Weiser; Edward janoff
Impact of the molecular form of immunoglobulin A on functional activity in defense against Streptococcus pneumoniae.
Infection and immunity 2007;75(4):1801-10.
2007: Blaise Corthésy; H. Rex Gaskins; Annick Mercenier
Cross-talk between probiotic bacteria and the host immune system.
The Journal of nutrition 2007;137(3 Suppl 2):781S-90S.
2007: Blaise Corthésy
Roundtrip ticket for secretory IgA: role in mucosal homeostasis?
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):27-32.
2006: Blaise Corthésy; Yann Benureau; Clémentine Perrier; Cynthia FOURGEUX; Nathalie Parez; Harry B Greenberg; Isabelle Schwartz-Cornil
Rotavirus anti-VP6 secretory immunoglobulin A contributes to protection via intracellular neutralization but not via immune exclusion.
Journal of virology 2006;80(21):10692-9.
2006: E Bernasconi; Rodolphe Fritsché; Blaise Corthésy
Specific effects of denaturation, hydrolysis and exposure to Lactococcus lactis on bovine beta-lactoglobulin transepithelial transport, antigenicity and allergenicity.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006;36(6):803-14.
2006: Clémentine Perrier; norbert sprenger; Blaise Corthésy
Glycans on secretory component participate in innate protection against mucosal pathogens.
The Journal of biological chemistry 2006;281(20):14280-7.
2006: Adrian Zuercher; Rodolphe Fritsché; Blaise Corthésy; Annick Mercenier
Food products and allergy development, prevention and treatment.
Current opinion in biotechnology 2006;17(2):198-203.
2006: Michael Affolter; Gabriela E Bergonzelli; K Blaser; S Blum-Sperisen; Blaise Corthésy; Laurent B Fay; Clara Garcia-Rodenas; luisa lopes; Laure F Marvin-Guy; Annick Mercenier; D M Mutch; Alexandre Panchaud; Frédéric Raymond; C Schmidt-Weber; Alexandra Schneider Schumann; François Spertini; Gary Williamson; Martin Kussmann
-Omics for prevention: gene, protein and metabolite profiling to better understand individual disposition to disease.
Nestlé Nutrition workshop series. Paediatric programme 2006;57():247-50; discussion 250-5.
2005: James C Rice; Tao Peng; Jeff S Spence; Hui-Qun Wang; Randall M Goldblum; Blaise Corthésy; Bogdan Nowicki
Pyelonephritic Escherichia coli expressing P fimbriae decrease immune response of the mouse kidney.
Journal of the American Society of Nephrology : JASN 2005;16(12):3583-91.
2005: Blaise Corthésy; Soledad Boris; Patrick Isler; Corinne Grangette; Annick Mercenier
Oral immunization of mice with lactic acid bacteria producing Helicobacter pylori urease B subunit partially protects against challenge with Helicobacter felis.
The Journal of infectious diseases 2005;192(8):1441-9.
2005: Laurent Favre; François Spertini; Blaise Corthésy
Secretory IgA possesses intrinsic modulatory properties stimulating mucosal and systemic immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(5):2793-800.
2004: Samantha Jilek; Elke Walter; Hans P Merkle; Blaise Corthésy
Modulation of allergic responses in mice by using biodegradable poly(lactide-co-glycolide) microspheres.
The Journal of allergy and clinical immunology 2004;114(4):943-50.
2004: José Berdoz; Blaise Corthésy
Human polymeric IgA is superior to IgG and single-chain Fv of the same monoclonal specificity to inhibit urease activity associated with Helicobacter pylori.
Molecular immunology 2004;41(10):1013-22.
2004: Jacques Rey; Nathalie Garin; François Spertini; Blaise Corthésy
Targeting of secretory IgA to Peyer's patch dendritic and T cells after transport by intestinal M cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):3026-33.
2004: Francesca Stingele; Blaise Corthésy; Nicole Kusy; Steven A Porcelli; Dennis L Kasper; Arthur O Tzianabos
Zwitterionic polysaccharides stimulate T cells with no preferential V beta usage and promote anergy, resulting in protection against experimental abscess formation.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1483-90.
2003: Irène Corthésy-Theulaz; Blaise Corthésy; Daniel Bachmann; Dominique Velin; Jean-Pierre Kraehenbuhl
Passive immunity in Helicobacter-challenged neonatal mice conferred by immunized dams lasts until weaning.
Infection and immunity 2003;71(4):2226-9.
2003: Laurent I Favre; François Spertini; Blaise Corthésy
Simplified procedure to recover recombinant antigenized secretory IgA to be used as a vaccine vector.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;786(1-2):143-51.
2003: Blaise Corthésy
Recombinant secretory immunoglobulin A in passive immunotherapy: linking immunology and biotechnology.
Current pharmaceutical biotechnology 2003;4(1):51-67.
2003: Armelle Phalipon; Blaise Corthésy
Novel functions of the polymeric Ig receptor: well beyond transport of immunoglobulins.
Trends in immunology 2003;24(2):55-8.
2002: Sandra Cottet; Irène Corthésy-Theulaz; François Spertini; Blaise Corthésy
Microaerophilic conditions permit to mimic in vitro events occurring during in vivo Helicobacter pylori infection and to identify Rho/Ras-associated proteins in cellular signaling.
The Journal of biological chemistry 2002;277(37):33978-86.
2002: Nicholas J Mantis; Marsha C Cheung; Koteswara R Chintalacharuvu; Jacques Rey; Blaise Corthésy; Marian R Neutra
Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):1844-51.
2002: Armelle Phalipon; Ana Cardona; Jean-Pierre Kraehenbuhl; Léna Edelman; Philippe J Sansonetti; Blaise Corthésy
Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo.
Immunity 2002;17(1):107-15.
2002: Eric Bernasconi; Jacques-Edouard Germond; Michèle Delley; Rodolphe Fritsché; Blaise Corthésy
Lactobacillus bulgaricus proteinase expressed in Lactococcus lactis is a powerful carrier for cell wall-associated and secreted bovine beta-lactoglobulin fusion proteins.
Applied and environmental microbiology 2002;68(6):2917-23.
2002: Jianmei Yu; Frederick J Cassels; Tanya Scharton-Kersten; Scott A Hammond; Antoinette Hartman; Evelina Angov; Blaise Corthésy; Carl R Alving; Gregory M Glenn
Transcutaneous immunization using colonization factor and heat-labile enterotoxin induces correlates of protective immunity for enterotoxigenic Escherichia coli.
Infection and immunity 2002;70(3):1056-68.
2002: Blaise Corthésy
Recombinant immunoglobulin A: powerful tools for fundamental and applied research.
Trends in biotechnology 2002;20(2):65-71.
2001: Samantha Jilek; Catherine Barbey; François Spertini; Blaise Corthésy
Antigen-independent suppression of the allergic immune response to bee venom phospholipase A(2) by DNA vaccination in CBA/J mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):3612-21.
2000: H Stubbe; José Berdoz; Jean-Pierre Kraehenbuhl; Blaise Corthésy
Polymeric IgA is superior to monomeric IgA and IgG carrying the same variable domain in preventing Clostridium difficile toxin A damaging of T84 monolayers.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(4):1952-60.
1999: Blaise Corthésy; François Spertini
Secretory immunoglobulin A: from mucosal protection to vaccine development.
Biological chemistry 1999;380(11):1251-62.
1999: P Crottet; Blaise Corthésy
Mapping the interaction between murine IgA and murine secretory component carrying epitope substitutions reveals a role of domains II and III in covalent binding to IgA.
The Journal of biological chemistry 1999;274(44):31456-62.
1999: P Crottet; Manuel Peitsch; C Servis; Blaise Corthésy
Covalent homodimers of murine secretory component induced by epitope substitution unravel the capacity of the polymeric Ig receptor to dimerize noncovalently in the absence of IgA ligand.
The Journal of biological chemistry 1999;274(44):31445-55.
1999: P Crottet; Sandra Cottet; Blaise Corthésy
Expression, purification and biochemical characterization of recombinant murine secretory component: a novel tool in mucosal immunology.
The Biochemical journal 1999;341 ( Pt 2)():299-306.
1999: M Houimel; Jean-Pierre Mach; Irène Corthésy-Theulaz; Blaise Corthésy; Igor Fisch
New inhibitors of Helicobacter pylori urease holoenzyme selected from phage-displayed peptide libraries.
European journal of biochemistry / FEBS 1999;262(3):774-80.
1999: José Berdoz; C T Blanc; M Reinhardt; Jean-Pierre Kraehenbuhl; Blaise Corthésy
In vitro comparison of the antigen-binding and stability properties of the various molecular forms of IgA antibodies assembled and produced in CHO cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3029-34.
1998: P Crottet; Blaise Corthésy
Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab')2: a possible implication for mucosal defense.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5445-53.
1997: Sandra Cottet; Blaise Corthésy
Cellular processing limits the heterologous expression of secretory component in mammalian cells.
European journal of biochemistry / FEBS 1997;246(1):23-31.
1997: Blaise Corthésy
Recombinant secretory IgA for immune intervention against mucosal pathogens.
Biochemical Society transactions 1997;25(2):471-5.
1996: Blaise Corthésy; M Kaufmann; A Phalipon; Manuel Peitsch; Marian R Neutra; J P Kraehenbuhl
A pathogen-specific epitope inserted into recombinant secretory immunoglobulin A is immunogenic by the oral route.
The Journal of biological chemistry 1996;271(52):33670-7.
1995: E Roulet; Marie-Therese Armentero; G Krey; Blaise Corthésy; Christine Dreyer; Nicolas Mermod; Walter Wahli
Regulation of the DNA-binding and transcriptional activities of Xenopus laevis NFI-X by a novel C-terminal domain.
Molecular and cellular biology 1995;15(10):5552-62.
1995: L Rindisbacher; S Cottet; Riccardo Wittek; J P Kraehenbuhl; Blaise Corthésy
Production of human secretory component with dimeric IgA binding capacity using viral expression systems.
The Journal of biological chemistry 1995;270(23):14220-8.
1995: J P Kraehenbuhl; S Kerneis; J Berdoz; Blaise Corthésy; L Rindisbacher; Irène Corthésy-Theulaz; A Phalipon; Marian R Neutra; Eric Pringault
Molecular events in production and transport of secretory IgA: a basis for design of reagents for passive immune protection.
Veterinary research 1995;26(3):231-2.
1994: Blaise Corthésy; Peter N Kao
Purification by DNA affinity chromatography of two polypeptides that contact the NF-AT DNA binding site in the interleukin 2 promoter.
The Journal of biological chemistry 1994;269(32):20682-90.
1994: Peter N Kao; Lei Chen; G Brock; J Ng; J Kenny; A J Smith; Blaise Corthésy
Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90.
The Journal of biological chemistry 1994;269(32):20691-9.
1991: W M Flanagan; Blaise Corthésy; R J Bram; Gerald R Crabtree
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A.
Nature 1991;352(6338):803-7.
1991: Blaise Corthésy; Irène Corthésy-Theulaz; Jean-René Cardinaux; Walter Wahli
A liver protein fraction regulating hormone-dependent in vitro transcription from the vitellogenin genes induces their expression in Xenopus oocytes.
Molecular endocrinology (Baltimore, Md.) 1991;5(2):159-69.
1990: Blaise Corthésy; Francois Claret; Walter Wahli
Estrogen receptor level determines sex-specific in vitro transcription from the Xenopus vitellogenin promoter.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(20):7878-82.
1990: Blaise Corthésy; P Léonnard; Walter Wahli
Transcriptional potentiation of the vitellogenin B1 promoter by a combination of both nucleosome assembly and transcription factors: an in vitro dissection.
Molecular and cellular biology 1990;10(8):3926-33.
1989: Blaise Corthésy; Jean-René Cardinaux; Francois Claret; Walter Wahli
A nuclear factor I-like activity and a liver-specific repressor govern estrogen-regulated in vitro transcription from the Xenopus laevis vitellogenin B1 promoter.
Molecular and cellular biology 1989;9(12):5548-62.
1989: Walter Wahli; E Martinez; Blaise Corthésy; Jean-René Cardinaux
cis- and trans-acting elements of the estrogen-regulated vitellogenin gene B1 of Xenopus laevis.
Journal of steroid biochemistry 1989;34(1-6):17-32.
1988: Blaise Corthésy; R Hipskind; I Theulaz; Walter Wahli
Estrogen-dependent in vitro transcription from the vitellogenin promoter in liver nuclear extracts.
Science (New York, N.Y.) 1988;239(4844):1137-9.
1987: B ten Heggeler-Bordier; R Hipskind; A Seiler-Tuyns; E Martinez; Blaise Corthésy; Walter Wahli
Electron microscopic visualization of protein-DNA interactions at the estrogen responsive element and in the first intron of the Xenopus laevis vitellogenin gene.
The EMBO journal 1987;6(6):1715-20.