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Barbara Cosimelli

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Publications

TOP 3
Pierfranco Ioan; Marco Pierini; Elda Severi; Francesco Sirci; Domenico Spinelli; Alberto Chiarini; Alessia Ciogli; Barbara Cosimelli; Gabriele Cruciani; Francesco Gasparrini; Roberta Budriesi; Emanuele Carosati
Absolute configuration and biological profile of two thiazinooxadiazol-3-ones with L-type calcium channel activity: a study of the structural effects.
Sabrina Taliani; Maria Letizia Trincavelli; Elisabetta Barresi; Sandro Cosconati; Barbara Cosimelli; Simona Daniele; Salvatore Di Maro; Giovanni Greco; Concettina La Motta; Luciana Marinelli; Anna Maria Marini; Claudia Martini; Ettore Novellino; Isabella Pugliesi; Silvia Salerno; Francesca Simorini; Federico Da Settimo
3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists.
Barbara Cosimelli; Luciana Marinelli; Ettore Novellino; Sandro Cosconati; Giovanni Greco
From the pharmacophore to the homology model of the benzodiazepine receptor: the indolyglyoxylamides affair.

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All Publications

2012: Pierfranco Ioan; Marco Pierini; Elda Severi; Francesco Sirci; Domenico Spinelli; Alberto Chiarini; Alessia Ciogli; Barbara Cosimelli; Gabriele Cruciani; Francesco Gasparrini; Roberta Budriesi; Emanuele Carosati
Absolute configuration and biological profile of two thiazinooxadiazol-3-ones with L-type calcium channel activity: a study of the structural effects.
Organic & biomolecular chemistry 2012;10(45):8994-9003.
2012: Sabrina Taliani; Maria Letizia Trincavelli; Elisabetta Barresi; Sandro Cosconati; Barbara Cosimelli; Simona Daniele; Salvatore Di Maro; Giovanni Greco; Concettina La Motta; Luciana Marinelli; Anna Maria Marini; Claudia Martini; Ettore Novellino; Isabella Pugliesi; Silvia Salerno; Francesca Simorini; Federico Da Settimo
3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists.
Journal of medicinal chemistry 2012;55(4):1490-9.
2012: Barbara Cosimelli; Luciana Marinelli; Ettore Novellino; Sandro Cosconati; Giovanni Greco
From the pharmacophore to the homology model of the benzodiazepine receptor: the indolyglyoxylamides affair.
Current topics in medicinal chemistry 2012;12(4):321-32.
2011: Barbara Cosimelli; Federico Da Settimo; Simona Daniele; Matteo Fornai; Giovanni Greco; Concettina La Motta; Ettore Novellino; Isabella Pugliesi; Annalisa Sala; Elda Severi; Sabrina Taliani; Maria Letizia Trincavelli; luca Antonioli; Corrado Blandizzi; Rocchina Colucci; Claudia Martini
Derivatives of benzimidazol-2-ylquinoline and benzimidazol-2-ylisoquinoline as selective A1 adenosine receptor antagonists with stimulant activity on human colon motility.
ChemMedChem 2011;6(10):1909-18.
2011: Barbara Cosimelli; Barbara Costa; Eleonora Da Pozzo; Federico Da Settimo; Giovanni Greco; Concettina La Motta; Ettore Novellino; Elda Severi; Francesca Simorini; Sabrina Taliani; Sara Bendinelli; Claudia Martini
Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein.
European journal of medicinal chemistry 2011;46(9):4506-20.
2011: Barbara Cosimelli; Matteo Micucci; Ettore Novellino; Elda Severi; Roberta Budriesi; Mauro Cataldi; Anna Cavaccini; Alberto Chiarini; Pierfranco Ioan
Preliminary finding on a new calcium channel entry blocker chemotype: 5,6-diamino-4-hydroxy-2-mercaptopyrimidine derivatives.
Journal of medicinal chemistry 2011;54(15):5597-601.
2010: Sabrina Taliani; Eleonora Da Pozzo; Marusca Bellandi; Sara Bendinelli; Isabella Pugliesi; Francesca Simorini; Concettina La Motta; Silvia Salerno; Anna Maria Marini; Federico Da Settimo; Barbara Cosimelli; Giovanni Greco; Ettore Novellino; Claudia Martini
Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization.
Journal of medicinal chemistry 2010;53(10):4085-93.
2010: Sabrina Taliani; Concettina La Motta; Laura Mugnaini; Francesca Simorini; Silvia Salerno; Anna Maria Marini; Federico Da Settimo; Sandro Cosconati; Barbara Cosimelli; Giovanni Greco; Vittorio Limongelli; Luciana Marinelli; Ettore Novellino; Osele Ciampi; Simona Daniele; Maria Letizia Trincavelli; Claudia Martini
Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.
Journal of medicinal chemistry 2010;53(10):3954-63.
2009: Barbara Cosimelli; Camilla Zaira Lanza; Erika Scavetta; Elda Severi; Domenico Spinelli; Marco Stenta; Domenica Tonelli
ortho-Substituted (aryl)(3-nitrobenzo[b]thiophen-2-yl)amines: study of the electrochemical behavior.
The journal of physical chemistry. A 2009;113(38):10260-3.
2009: Sabrina Taliani; Barbara Cosimelli; Federico Da Settimo; Anna Maria Marini; Concettina La Motta; Francesca Simorini; Silvia Salerno; Ettore Novellino; Giovanni Greco; Sandro Cosconati; Luciana Marinelli; F Salvetti; Gianluca L'Abbate; Silvia Trasciatti; Marina Montali; Barbara Costa; Claudia Martini
Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.
Journal of medicinal chemistry 2009;52(12):3723-34.
2009: Roberta Budriesi; Barbara Cosimelli; Pierfranco Ioan; Maria Paola Ugenti; Emanuele Carosati; Maria Frosini; Fabio Fusi; Raffaella Spisani; Simona Saponara; Gabriele Cruciani; Ettore Novellino; Domenico Spinelli; Alberto Chiarini
L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives.
Journal of medicinal chemistry 2009;52(8):2352-62.
2008: Emanuele Carosati; Roberta Budriesi; Pierfranco Ioan; Maria P Ugenti; Maria Frosini; Fabio Fusi; Gaetano Corda; Barbara Cosimelli; Domenico Spinelli; Alberto Chiarini; Gabriele Cruciani
Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening.
Journal of medicinal chemistry 2008;51(18):5552-65.
2007: Federico Da Settimo; Giampaolo Primofiore; Sabrina Taliani; Anna Maria Marini; Concettina La Motta; Francesca Simorini; Silvia Salerno; Valentina Sergianni; Tiziano Tuccinardi; Adriano Martinelli; Barbara Cosimelli; Giovanni Greco; Ettore Novellino; Osele Ciampi; Maria Letizia Trincavelli; Claudia Martini
5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.
Journal of medicinal chemistry 2007;50(23):5676-84.
2007: Philip J Stephens; Frank J Devlin; Francesco Gasparrini; Alessia Ciogli; Domenico Spinelli; Barbara Cosimelli
Determination of the absolute configuration of a chiral oxadiazol-3-one calcium channel blocker, resolved using chiral chromatography, via concerted density functional theory calculations of its vibrational circular dichroism, electronic circular dichroism, and optical rotation.
The Journal of organic chemistry 2007;72(13):4707-15.
2007: Giampaolo Primofiore; Sabrina Taliani; Federico Da Settimo; Anna Maria Marini; Concettina La Motta; Francesca Simorini; Maria Paola Patrizi; Valentina Sergianni; Ettore Novellino; Giovanni Greco; Barbara Cosimelli; Vincenzo Calderone; Marina Montali; Francois Besnard; Claudia Martini
Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.
Journal of medicinal chemistry 2007;50(7):1627-34.
2007: Sabrina Taliani; Francesca Simorini; Valentina Sergianni; Concettina La Motta; Federico Da Settimo; Barbara Cosimelli; Enrico Abignente; Giovanni Greco; Ettore Novellino; Leonardo Rossi; Vittorio Gremigni; Francesca Spinetti; Beatrice Chelli; Claudia Martini
New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation.
Journal of medicinal chemistry 2007;50(2):404-7.
2007: Roberta Budriesi; Barbara Cosimelli; Pierfranco Ioan; Emanuele Carosati; Maria Paola Ugenti; Raffaella Spisani
Diltiazem analogues: the last ten years on structure activity relationships.
Current medicinal chemistry 2007;14(3):279-87.
2006: Emanuele Carosati; Gabriele Cruciani; Alberto Chiarini; Roberta Budriesi; Pierfranco Ioan; Raffaella Spisani; Domenico Spinelli; Barbara Cosimelli; Fabio Fusi; Maria Frosini; Rosanna Matucci; Francesco Gasparrini; Alessia Ciogli; Philip J Stephens; Frank J Devlin
Calcium channel antagonists discovered by a multidisciplinary approach.
Journal of medicinal chemistry 2006;49(17):5206-16.
2006: Giampaolo Primofiore; Federico Da Settimo; Anna Maria Marini; Sabrina Taliani; Concettina La Motta; Francesca Simorini; Ettore Novellino; Giovanni Greco; Barbara Cosimelli; Marina Ehlardo; Annalisa Sala; Francois Besnard; Marina Montali; Claudia Martini
Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides.
Journal of medicinal chemistry 2006;49(8):2489-95.
2005: Ettore Novellino; Barbara Cosimelli; Marina Ehlardo; Giovanni Greco; Manuela Iadanza; Antonio Lavecchia; Maria Grazia Rimoli; Annalisa Sala; Antonio Da Settimo; Giampaolo Primofiore; Federico Da Settimo; Sabrina Taliani; Concettina La Motta; Karl-Norbert Klotz; Daniela Tuscano; Maria Letizia Trincavelli; Claudia Martini
2-(Benzimidazol-2-yl)quinoxalines: a novel class of selective antagonists at human A(1) and A(3) adenosine receptors designed by 3D database searching.
Journal of medicinal chemistry 2005;48(26):8253-60.
2005: Giampaolo Primofiore; Federico Da Settimo; Sabrina Taliani; Silvia Salerno; Ettore Novellino; Giovanni Greco; Barbara Cosimelli; Francois Besnard; Barbara Costa; Marina Montali; Claudia Martini
High affinity central benzodiazepine receptor ligands: synthesis and biological evaluation of a series of phenyltriazolobenzotriazindione derivatives.
Journal of medicinal chemistry 2005;48(8):2936-43.
2005: Roberta Budriesi; Emanuele Carosati; Alberto Chiarini; Barbara Cosimelli; Gabriele Cruciani; Pierfranco Ioan; Domenico Spinelli; Raffaella Spisani
A new class of selective myocardial calcium channel modulators. 2. Role of the acetal chain in oxadiazol-3-one derivatives.
Journal of medicinal chemistry 2005;48(7):2445-56.
2002: Barbara Cosimelli; Vincenzo Frenna; Susanna Guernelli; Camilla Zaira Lanza; Gabriella Macaluso; Giovanni Petrillo; Domenico Spinelli
The first kinetic evidence for acid catalysis in a monocyclic rearrangement of heterocycles: conversion of the Z-phenylhydrazone of 5-amino-3-benzoyl-1,2,4-oxadiazole into N,5-diphenyl-2H-1,2,3-triazol-4-ylurea.
The Journal of organic chemistry 2002;67(23):8010-8.
2002: Ettore Novellino; Enrico Abignente; Barbara Cosimelli; Giovanni Greco; Manuela Iadanza; Sonia Laneri; Antonio Lavecchia; Maria Grazia Rimoli; Federico Da Settimo; Giampaolo Primofiore; Daniela Tuscano; Letizia Trincavelli; Claudia Martini
Design, synthesis and biological evaluation of novel N-alkyl- and N-acyl-(7-substituted-2-phenylimidazo[1,2-a][1,3,5]triazin-4-yl)amines (ITAs) as novel A(1) adenosine receptor antagonists.
Journal of medicinal chemistry 2002;45(23):5030-6.
2002: Roberta Budriesi; Barbara Cosimelli; Pierfranco Ioan; Camilla Zaira Lanza; Domenico Spinelli; Alberto Chiarini
Cardiovascular characterization of [1,4]thiazino[3,4-c][1,2,4]oxadiazol-1-one derivatives: selective myocardial calcium channel modulators.
Journal of medicinal chemistry 2002;45(16):3475-81.
2001: Barbara Cosimelli; Susanna Guernelli; Domenico Spinelli; Silvestre Buscemi; Vincenzo Frenna; Gabriella Macaluso
On the synthesis and reactivity of the Z-2,4-dinitrophenylhydrazone of 5-amino-3-benzoyl-1,2,4-oxadiazole.
The Journal of organic chemistry 2001;66(18):6124-9.