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Erminio Costa

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
138
Guidotti, Alessandro
41
Grayson, Dennis
22
Vicini, Stefano
22
Wroblewski, Jarda
18
Veldic, Marin
18
Pinna, Graziano
17
Dong, Erbo
16
Pesold, Christine
15
Auta, James
12
Impagnatiello, F
12
Manev, Hari
11
Davis, John
11
Caruncho, Héctor
10
Brooker, Gary
9
Alho, Hannu

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Publications

TOP 3
Zhubi A; Veldic M; Puri N V; Kadriu B; Caruncho H; Loza I; Sershen H; Lajtha A; Smith R C; Guidotti A; Davis J M; Costa E
An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes.
Pinna Graziano; Costa Erminio; Guidotti Alessandro
SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake.
Kadriu Bashkim; Guidotti Alessandro; Costa Erminio; Auta James
Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage.

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All Publications

2009: Zhubi A; Veldic M; Puri N V; Kadriu B; Caruncho H; Loza I; Sershen H; Lajtha A; Smith R C; Guidotti A; Davis J M; Costa E
An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes.
Schizophrenia research 2009;111(1-3):115-22.
2009: Pinna Graziano; Costa Erminio; Guidotti Alessandro
SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake.
Current opinion in pharmacology 2009;9(1):24-30.
2009: Kadriu Bashkim; Guidotti Alessandro; Costa Erminio; Auta James
Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage.
Toxicology 2009;256(3):164-74.
2009: Guidotti Alessandro; Dong Erbo; Kundakovic Marija; Satta Rosalba; Grayson Dennis R; Costa Erminio
Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling.
Trends in pharmacological sciences 2009;30(2):55-60.
2009: Costa Erminio; Chen Ying; Dong Erbo; Grayson Dennis R; Kundakovic Marija; Maloku Ekrem; Ruzicka William; Satta Rosalba; Veldic Marin; Zhubi Adrian; Guidotti Alessandro
GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability.
Expert review of neurotherapeutics 2009;9(1):87-98.
2008: Satta R; Maloku E; Zhubi A; Pibiri F; Hajos M; Costa E; Guidotti A
Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(42):16356-61.
2008: Pinna Graziano; Agis-Balboa Roberto Carlos; Pibiri Fabio; Nelson Marianela; Guidotti Alessandro; Costa Erminio
Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice.
Neurochemical research 2008;33(10):1990-2007.
2008: Pibiri Fabio; Kozikowski Alan P; Pinna Graziano; Auta James; Kadriu Bashkim; Costa Erminio; Guidotti Alessandro
The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):14169-74.
2008: Dong E; Nelson M; Grayson D R; Costa E; Guidotti A
Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13614-9.
2008: Auta James; Impagnatiello Francesco; Kadriu Bashkim; Guidotti Alessandro; Costa Erminio
Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem.
Neuropharmacology 2008;55(2):148-53.
2008: Pibiri Fabio; Nelson Marianela; Guidotti Alessandro; Costa Erminio; Pinna Graziano
Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(14):5567-72.
2007: Agís-Balboa Roberto C; Pinna Graziano; Pibiri Fabio; Kadriu Bashkim; Costa Erminio; Guidotti Alessandro
Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18736-41.
2007: Ruzicka W B; Zhubi A; Veldic M; Grayson D R; Costa E; Guidotti A
Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection.
Molecular psychiatry 2007;12(4):385-97.
2007: Dong E; Guidotti A; Grayson D R; Costa E
Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(11):4676-81.
2007: Veldic Marin; Kadriu Bashkim; Maloku Ekrem; Agis-Balboa Roberto C; Guidotti Alessandro; Davis John M; Costa Erminio
Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder.
Schizophrenia research 2007;91(1-3):51-61.
2007: Kundakovic Marija; Chen Ying; Costa Erminio; Grayson Dennis R
DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes.
Molecular pharmacology 2007;71(3):644-53.
2007: Costa Erminio; Dong Erbo; Grayson Dennis R; Guidotti Alessandro; Ruzicka William; Veldic Marin
Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability.
Epigenetics : official journal of the DNA Methylation Society 2007;2(1):29-36.
2007: Guidotti Alessandro; Ruzicka William; Grayson Dennis R; Veldic Marin; Pinna Graziano; Davis John M; Costa Erminio
S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis.
Neuroreport 2007;18(1):57-60.
2006: Sharma Rajiv P; Rosen Cherise; Kartan Saritha; Guidotti Alessandro; Costa Erminio; Grayson Dennis R; Chase Kayla
Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical population.
Schizophrenia research 2006;88(1-3):227-31.
2006: Agís-Balboa Roberto C; Pinna Graziano; Zhubi Adrian; Maloku Ekrem; Veldic Marin; Costa Erminio; Guidotti Alessandro
Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(39):14602-7.
2006: Grayson Dennis R; Chen Ying; Costa Erminio; Dong Erbo; Guidotti Alessandro; Kundakovic Marija; Sharma Rajiv P
The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia.
Pharmacology & therapeutics 2006;111(1):272-86.
2006: Pinna Graziano; Costa Erminio; Guidotti Alessandro
Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake.
Psychopharmacology 2006;186(3):362-72.
2006: Pinna Graziano; Agis-Balboa Roberto C; Zhubi Adrian; Matsumoto Kinzo; Grayson Dennis R; Costa Erminio; Guidotti Alessandro
Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4275-80.
2006: Simonini M V; Camargo L M; Dong E; Maloku E; Veldic M; Costa E; Guidotti A
The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(5):1587-92.
2006: Costa E; Dong E; Grayson D R; Ruzicka W B; Simonini M V; Veldic M; Guidotti A
Epigenetic targets in GABAergic neurons to treat schizophrenia.
Advances in pharmacology (San Diego, Calif.) 2006;54():95-117.
2006: Tueting Patricia; Doueiri Mohemed-Salim; Guidotti Alessandro; Davis John M; Costa Erminio
Reelin down-regulation in mice and psychosis endophenotypes.
Neuroscience and biobehavioral reviews 2006;30(8):1065-77.
2005: Auta James; Costa Erminio; Davis John M; Guidotti Alessandro
Imidazenil: an antagonist of the sedative but not the anticonvulsant action of diazepam.
Neuropharmacology 2005;49(3):425-9.
2005: Dong E; Agis-Balboa R C; Simonini M V; Grayson D R; Costa E; Guidotti A
Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(35):12578-83.
2005: Sharma Rajiv P; Grayson Dennis R; Guidotti Alessandro; Costa Erminio
Chromatin, DNA methylation and neuron gene regulation--the purpose of the package.
Journal of psychiatry & neuroscience : JPN 2005;30(4):257-63.
2005: Guidotti Alessandro; Auta James; Davis John M; Dong Erbo; Grayson Dennis R; Veldic Marin; Zhang Xianquan; Costa Erminio
GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon.
Psychopharmacology 2005;180(2):191-205.
2005: Matsumoto Kinzo; Pinna Graziano; Puia Giuli; Guidotti Alessandro; Costa Erminio
Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis.
Stress (Amsterdam, Netherlands) 2005;8(2):85-93.
2005: Grayson Dennis R; Jia Xiaomei; Chen Ying; Sharma Rajiv P; Mitchell Colin P; Guidotti Alessandro; Costa Erminio
Reelin promoter hypermethylation in schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(26):9341-6.
2005: Mitchell Colin P; Chen Ying; Kundakovic Marija; Costa Erminio; Grayson Dennis R
Histone deacetylase inhibitors decrease reelin promoter methylation in vitro.
Journal of neurochemistry 2005;93(2):483-92.
2005: Tremolizzo Lucio; Doueiri Mohemed-Salim; Dong Erbo; Grayson Dennis R; Davis John; Pinna Graziano; Tueting Patricia; Rodriguez-Menendez Virginia; Costa Erminio; Guidotti Alessandro
Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice.
Biological psychiatry 2005;57(5):500-9.
2005: Costa Erminio; Guidotti Alessandro; Veldic Marin
Should allosteric positive modulators of GABA(A) receptors be tested in the treatment of schizophrenia?
Schizophrenia research 2005;73(2-3):367-8.
2005: Veldic Marin; Guidotti Alessandro; Maloku Ekrem; Davis John M; Costa Erminio
In psychosis, cortical interneurons overexpress DNA-methyltransferase 1.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):2152-7.
2005: Pinna Graziano; Costa Erminio; Guidotti Alessandro
Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):2135-40.
2005: Noh Jai Sung; Sharma Rajiv P; Veldic Marin; Salvacion Alain A; Jia Xiaomei; Chen Ying; Costa Erminio; Guidotti Alessandro; Grayson Dennis R
DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(5):1749-54.
2004: Carboni G; Tueting P; Tremolizzo L; Sugaya I; Davis J; Costa E; Guidotti A
Enhanced dizocilpine efficacy in heterozygous reeler mice relates to GABA turnover downregulation.
Neuropharmacology 2004;46(8):1070-81.
2004: Pinna Graziano; Costa Erminio; Guidotti Alessandro
Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(16):6222-5.
2004: Auta James; Costa Erminio; Davis John; Guidotti Alessandro
Imidazenil: a potent and safe protective agent against diisopropyl fluorophosphate toxicity.
Neuropharmacology 2004;46(3):397-403.
2004: Veldic M; Caruncho H J; Liu W S; Davis J; Satta R; Grayson D R; Guidotti A; Costa E
DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(1):348-53.
2004: Pinna Graziano; Agis-Balboa Roberto C; Doueiri Mohemed-Salim; Guidotti Alessandro; Costa Erminio
Brain neurosteroids in gender-related aggression induced by social isolation.
Critical reviews in neurobiology 2004;16(1-2):75-82.
2004: Costa E; Davis J M; Dong E; Grayson D R; Guidotti A; Tremolizzo L; Veldic M
A GABAergic cortical deficit dominates schizophrenia pathophysiology.
Critical reviews in neurobiology 2004;16(1-2):1-23.
2004: Costa E; Grayson D R; Veldic M; Guidotti A
Neurochemical basis for an epigenetic vision of synaptic organization.
International review of neurobiology 2004;59():73-91.
2003: Costa Erminio; Grayson Dennis R; Guidotti Alessandro
Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention?
Molecular interventions 2003;3(4):220-9.
2003: Dong Erbo; Caruncho Hector; Liu Wen Sheng; Smalheiser Neil R; Grayson Dennis R; Costa Erminio; Guidotti Alessandro
A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5479-84.
2003: Pinna Graziano; Dong Erbo; Matsumoto Kinzo; Costa Erminio; Guidotti Alessandro
In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):2035-40.
2003: Puia G; Mienville J-M; Matsumoto K; Takahata H; Watanabe H; Costa E; Guidotti A
On the putative physiological role of allopregnanolone on GABA(A) receptor function.
Neuropharmacology 2003;44(1):49-55.
2003: Costa Erminio; Grayson Dennis R; Mitchell Colin P; Tremolizzo Lucio; Veldic Marin; Guidotti Alessandro
GABAergic cortical neuron chromatin as a putative target to treat schizophrenia vulnerability.
Critical reviews in neurobiology 2003;15(2):121-42.
2002: Tremolizzo L; Carboni G; Ruzicka W B; Mitchell C P; Sugaya I; Tueting P; Sharma R; Grayson D R; Costa E; Guidotti A
An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):17095-100.
2002: Costa E; Auta J; Grayson D R; Matsumoto K; Pappas G D; Zhang X; Guidotti A
GABAA receptors and benzodiazepines: a role for dendritic resident subunit mRNAs.
Neuropharmacology 2002;43(6):925-37.
2002: Rodriguez Miguel A; Caruncho Hector J; Costa Erminio; Pesold Christine; Liu Wen-Sheng; Guidotti Alessandro
In Patas monkey, glutamic acid decarboxylase-67 and reelin mRNA coexpression varies in a manner dependent on layers and cortical areas.
The Journal of comparative neurology 2002;451(3):279-88.
2002: Chen Ying; Sharma Rajiv P; Costa Robert H; Costa Erminio; Grayson Dennis R
On the epigenetic regulation of the human reelin promoter.
Nucleic acids research 2002;30(13):2930-9.
2002: Kim H M; Qu T; Kriho V; Lacor P; Smalheiser N; Pappas G D; Guidotti A; Costa E; Sugaya K
Reelin function in neural stem cell biology.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(6):4020-5.
2002: Costa E; Chen Y; Davis J; Dong E; Noh J S; Tremolizzo L; Veldic M; Grayson D R; Guidotti A
REELIN and schizophrenia: a disease at the interface of the genome and the epigenome.
Molecular interventions 2002;2(1):47-57.
2002: Costa Erminio; Davis John; Pesold Christine; Tueting Patricia; Guidotti Alessandro
The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics.
Current opinion in pharmacology 2002;2(1):56-62.
2001: Guidotti A; Dong E; Matsumoto K; Pinna G; Rasmusson A M; Costa E
The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders.
Brain research. Brain research reviews 2001;37(1-3):110-5.
2001: Costa E; Davis J; Grayson D R; Guidotti A; Pappas G D; Pesold C
Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability.
Neurobiology of disease 2001;8(5):723-42.
2001: Izzo E; Auta J; Impagnatiello F; Pesold C; Guidotti A; Costa E
Glutamic acid decarboxylase and glutamate receptor changes during tolerance and dependence to benzodiazepines.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3483-8.
2001: Liu W S; Pesold C; Rodriguez M A; Carboni G; Auta J; Lacor P; Larson J; Condie B G; Guidotti A; Costa E
Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3477-82.
2001: Dong E; Matsumoto K; Uzunova V; Sugaya I; Takahata H; Nomura H; Watanabe H; Costa E; Guidotti A
Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2849-54.
2000: Guidotti A; Auta J; Davis J M; Di-Giorgi-Gerevini V; Dwivedi Y; Grayson D R; Impagnatiello F; Pandey G; Pesold C; Sharma R; Uzunov D; Costa E;
Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study.
Archives of general psychiatry 2000;57(11):1061-9.
2000: Guidotti A; Pesold C; Costa E
New neurochemical markers for psychosis: a working hypothesis of their operation.
Neurochemical research 2000;25(9-10):1207-18.
2000: Auta J; Lecca D; Nelson M; Guidotti A; Overstreet D H; Costa E; Javaid J I
Expression and function of striatal nAChRs differ in the flinders sensitive (FSL) and resistant (FRL) rat lines.
Neuropharmacology 2000;39(13):2624-31.
2000: Rodriguez M A; Pesold C; Liu W S; Kriho V; Guidotti A; Pappas G D; Costa E
Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3550-5.
2000: Lacor P N; Grayson D R; Auta J; Sugaya I; Costa E; Guidotti A
Reelin secretion from glutamatergic neurons in culture is independent from neurotransmitter regulation.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3556-61.
2000: Auta J; Guidotti A; Costa E
Imidazenil prevention of alprazolam-induced acquisition deficit in patas monkeys is devoid of tolerance.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2314-9.
2000: Smalheiser N R; Costa E; Guidotti A; Impagnatiello F; Auta J; Lacor P; Kriho V; Pappas G D
Expression of reelin in adult mammalian blood, liver, pituitary pars intermedia, and adrenal chromaffin cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1281-6.
2000: Pinna G; Uzunova V; Matsumoto K; Puia G; Mienville J M; Costa E; Guidotti A
Brain allopregnanolone regulates the potency of the GABA(A) receptor agonist muscimol.
Neuropharmacology 2000;39(3):440-8.
2000: Lecca D; Shim I; Costa E; Javaid J I
Striatal application of nicotine, but not of lobeline, attenuates dopamine release in freely moving rats.
Neuropharmacology 2000;39(1):88-98.
1999: Auta J; Longone P; Guidotti A; Costa E
The regulation of hippocampal nicotinic acetylcholine receptors (nAChRs) after a protracted treatment with selective or nonselective nAChR agonists.
Journal of molecular neuroscience : MN 1999;13(1-2):31-45.
1999: Matsumoto K; Uzunova V; Pinna G; Taki K; Uzunov D P; Watanabe H; Mienville J M; Guidotti A; Costa E
Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss.
Neuropharmacology 1999;38(7):955-63.
1999: Tueting P; Costa E; Dwivedi Y; Guidotti A; Impagnatiello F; Manev R; Pesold C
The phenotypic characteristics of heterozygous reeler mouse.
Neuroreport 1999;10(6):1329-34.
1999: Pesold C; Liu W S; Guidotti A; Costa E; Caruncho H J
Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):3217-22.
1998: Impagnatiello F; Guidotti A R; Pesold C; Dwivedi Y; Caruncho H; Pisu M G; Uzunov D P; Smalheiser N R; Davis J M; Pandey G N; Pappas G D; Tueting P; Sharma R P; Costa E
A decrease of reelin expression as a putative vulnerability factor in schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15718-23.
1998: Guidotti A; Costa E
Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3 alpha, 5 alpha-tetrahydroprogesterone (allopregnanolone) availability?
Biological psychiatry 1998;44(9):865-73.
1998: Giorgetti M; Javaid J I; Davis J M; Costa E; Guidotti A; Appel S B; Brodie M S
Imidazenil, a positive allosteric GABAA receptor modulator, inhibits the effects of cocaine on locomotor activity and extracellular dopamine in the nucleus accumbens shell without tolerance liability.
The Journal of pharmacology and experimental therapeutics 1998;287(1):58-66.
1998: Longone P; Impagnatiello F; Mienville J M; Costa E; Guidotti A
Changes in AMPA receptor-spliced variant expression and shift in AMPA receptor spontaneous desensitization pharmacology during cerebellar granule cell maturation in vitro.
Journal of molecular neuroscience : MN 1998;11(1):23-41.
1998: Uzunova V; Sheline Y; Davis J M; Rasmusson A; Uzunov D P; Costa E; Guidotti A
Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):3239-44.
1998: Pesold C; Impagnatiello F; Pisu M G; Uzunov D P; Costa E; Guidotti A; Caruncho H J
Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult rats.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):3221-6.
1997: Pesold C; Caruncho H J; Impagnatiello F; Berg M J; Fritschy J M; Guidotti A; Costa E
Tolerance to diazepam and changes in GABA(A) receptor subunit expression in rat neocortical areas.
Neuroscience 1997;79(2):477-87.
1997: Impagnatiello F; Oberto A; Longone P; Costa E; Guidotti A
7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(13):7053-8.
1997: Caruncho H J; Guidotti A; Lindstrom J; Costa E; Pesold C
Subcellular localization of the alpha 7 nicotinic receptor in rat cerebellar granule cell layer.
Neuroreport 1997;8(6):1431-3.
1996: Uzunov D P; Cooper T B; Costa E; Guidotti A
Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12599-604.
1996: Impagnatiello F; Pesold C; Longone P; Caruncho H; Fritschy J M; Costa E; Guidotti A
Modifications of gamma-aminobutyric acidA receptor subunit expression in rat neocortex during tolerance to diazepam.
Molecular pharmacology 1996;49(5):822-31.
1996: Zheng T M; Caruncho H J; Zhu W J; Vicini S; Ikonomovic S; Grayson D R; Costa E
Chronic flumazenil alters GABA(A) receptor subunit mRNA expression, translation product assembly and channel function in neuronal cultures.
The Journal of pharmacology and experimental therapeutics 1996;277(1):525-33.
1996: Longone P; Impagnatiello F; Guidotti A; Costa E
Reversible modification of GABAA receptor subunit mRNA expression during tolerance to diazepam-induced cognition dysfunction.
Neuropharmacology 1996;35(9-10):1465-73.
1995: Caruncho H J; Puia G; Mohler H; Costa E
The density and distribution of six GABAA receptor subunits in primary cultures of rat cerebellar granule cells.
Neuroscience 1995;67(3):583-93.
1995: Thompson D M; Guidotti A; DiBella M; Costa E
7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7667-71.
1995: Uzunov D P; Zivkovich I; Pirkle W H; Costa E; Guidotti A
Enantiomeric resolution with a new chiral stationary phase of 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide, a cognition-enhancing benzothiadiazine derivative.
Journal of pharmaceutical sciences 1995;84(8):937-42.
1995: Thompson D M; Auta J; Guidotti A; Costa E
Imidazenil, a new anxiolytic and anticonvulsant drug, attenuates a benzodiazepine-induced cognition deficit in monkeys.
The Journal of pharmacology and experimental therapeutics 1995;273(3):1307-12.
1995: Cheney D L; Uzunov D; Costa E; Guidotti A
Gas chromatographic-mass fragmentographic quantitation of 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(6):4641-50.
1995: Harris B T; Costa E; Grayson D R
Exposure of neuronal cultures to K+ depolarization or to N-methyl-D-aspartate increases the transcription of genes encoding the alpha 1 and alpha 5 GABAA receptor subunits.
Brain research. Molecular brain research 1995;28(2):338-42.
1995: Kiedrowski L; Costa E
Glutamate-induced destabilization of intracellular calcium concentration homeostasis in cultured cerebellar granule cells: role of mitochondria in calcium buffering.
Molecular pharmacology 1995;47(1):140-7.
1995: Ducic I; Caruncho H J; Zhu W J; Vicini S; Costa E
gamma-Aminobutyric acid gating of Cl- channels in recombinant GABAA receptors.
The Journal of pharmacology and experimental therapeutics 1995;272(1):438-45.
1995: Zivkovic I; Thompson D M; Bertolino M; Uzunov D; DiBella M; Costa E; Guidotti A
7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization.
The Journal of pharmacology and experimental therapeutics 1995;272(1):300-9.
1995: Costa E; Auta J; Caruncho H; Guidotti A; Impagnatiello F; Pesold C; Thompson D M
A search for a new anticonvulsant and anxiolytic benzodiazepine devoid of side effects and tolerance liability.
Advances in biochemical psychopharmacology 1995;48():75-92.
1994: De Erausquin G A; Costa E; Hanbauer I
Calcium homeostasis, free radical formation, and trophic factor dependence mechanisms in Parkinson's disease.
Pharmacological reviews 1994;46(4):467-82.
1994: Zheng T M; Zhu W J; Puia G; Vicini S; Grayson D R; Costa E; Caruncho H J
Changes in gamma-aminobutyrate type A receptor subunit mRNAs, translation product expression, and receptor function during neuronal maturation in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10952-6.
1994: Costa E; Cheney D L; Grayson D R; Korneyev A; Longone P; Pani L; Romeo E; Zivkovich E; Guidotti A
Pharmacology of neurosteroid biosynthesis. Role of the mitochondrial DBI receptor (MDR) complex.
Annals of the New York Academy of Sciences 1994;746():223-42.
1994: Auta J; Giusti P; Guidotti A; Costa E
Imidazenil, a partial positive allosteric modulator of GABAA receptors, exhibits low tolerance and dependence liabilities in the rat.
The Journal of pharmacology and experimental therapeutics 1994;270(3):1262-9.
1994: Romeo E; Cheney D L; Zivkovic I; Costa E; Guidotti A
Mitochondrial diazepam-binding inhibitor receptor complex agonists antagonize dizocilpine amnesia: putative role for allopregnanolone.
The Journal of pharmacology and experimental therapeutics 1994;270(1):89-96.
1994: Kharlamov A; Zivkovic I; Polo A; Armstrong D M; Costa E; Guidotti A
LIGA20, a lyso derivative of ganglioside GM1, given orally after cortical thrombosis reduces infarct size and associated cognition deficit.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(14):6303-7.
1994: Costa E; Auta J; Guidotti A; Korneyev A; Romeo E
The pharmacology of neurosteroidogenesis.
The Journal of steroid biochemistry and molecular biology 1994;49(4-6):385-9.
1994: Kiedrowski L; Wroblewski J T; Costa E
Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate.
Molecular pharmacology 1994;45(5):1050-4.
1994: Harris B T; Charlton M E; Costa E; Grayson D R
Quantitative changes in alpha 1 and alpha 5 gamma-aminobutyric acid type A receptor subunit mRNAs and proteins after a single treatment of cerebellar granule neurons with N-methyl-D-aspartate.
Molecular pharmacology 1994;45(4):637-48.
1994: Kiedrowski L; Brooker G; Costa E; Wroblewski J T
Glutamate impairs neuronal calcium extrusion while reducing sodium gradient.
Neuron 1994;12(2):295-300.
1994: de Erausquin G; Brooker G; Costa E; Hanbauer I
Persistent AMPA receptor stimulation alters [Ca2+]i homeostasis in cultures of embryonic dopaminergic neurons.
Brain research. Molecular brain research 1994;21(3-4):303-11.
1994: Puia G; Costa E; Vicini S
Functional diversity of GABA-activated Cl- currents in Purkinje versus granule neurons in rat cerebellar slices.
Neuron 1994;12(1):117-26.
1994: Polo A; Kirschner G; Guidotti A; Costa E
Brain content of glycosphingolipids after oral administration of monosialogangliosides GM1 and LIGA20 to rats.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1994;21(1):41-53.
1994: Costa E; Armstrong D M; Guidotti A; Kharlamov A; Kiedrowski L; Manev H; Polo A; Wroblewski J T
Gangliosides in the protection against glutamate excitotoxicity.
Progress in brain research 1994;101():357-73.
1994: Caruncho H J; Costa E
Double-immunolabelling analysis of GABAA receptor subunits in label-fracture replicas of cultured rat cerebellar granule cells.
Receptors & channels 1994;2(2):143-53.
1994: Rius R A; Guidotti A; Costa E
Pituitary adenylate cyclase activating polypeptide (PACAP) potently enhances tyrosine hydroxylase (TH) expression in adrenal chromaffin cells.
Life sciences 1994;54(22):1735-43.
1993: Korneyev A; Guidotti A; Costa E
Regional and interspecies differences in brain progesterone metabolism.
Journal of neurochemistry 1993;61(6):2041-7.
1993: Livsey C T; Costa E; Vicini S
Glutamate-activated currents in outside-out patches from spiny versus aspiny hilar neurons of rat hippocampal slices.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(12):5324-33.
1993: Kozikowski A P; Ma D; Brewer J; Sun S; Costa E; Romeo E; Guidotti A
Chemistry, binding affinities, and behavioral properties of a new class of "antineophobic" mitochondrial DBI receptor complex (mDRC) ligands.
Journal of medicinal chemistry 1993;36(20):2908-20.
1993: Korneyev A; Pan B S; Polo A; Romeo E; Guidotti A; Costa E
Stimulation of brain pregnenolone synthesis by mitochondrial diazepam binding inhibitor receptor ligands in vivo.
Journal of neurochemistry 1993;61(4):1515-24.
1993: Romeo E; Cavallaro S; Korneyev A; Kozikowski A P; Ma D; Polo A; Costa E; Guidotti A
Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex.
The Journal of pharmacology and experimental therapeutics 1993;267(1):462-71.
1993: Giusti P; Ducic I; Puia G; Arban R; Walser A; Guidotti A; Costa E
Imidazenil: a new partial positive allosteric modulator of gamma-aminobutyric acid (GABA) action at GABAA receptors.
The Journal of pharmacology and experimental therapeutics 1993;266(2):1018-28.
1993: Kharlamov A; Guidotti A; Costa E; Hayes R; Armstrong D
Semisynthetic sphingolipids prevent protein kinase C translocation and neuronal damage in the perifocal area following a photochemically induced thrombotic brain cortical lesion.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(6):2483-94.
1993: Sun F Y; Costa E; Mocchetti I
Adrenal steroids mediate the increase of hippocampal nerve growth factor biosynthesis following bicuculline convulsions.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1993;8(3):219-25.
1993: Fohrman E B; de Erausquin G; Costa E; Wojcik W J
Muscarinic m3 receptors and dynamics of intracellular Ca2+ cerebellar granule neurons.
European journal of pharmacology 1993;245(3):263-71.
1993: Auta J; Romeo E; Kozikowski A; Ma D; Costa E; Guidotti A
Participation of mitochondrial diazepam binding inhibitor receptors in the anticonflict, antineophobic and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives.
The Journal of pharmacology and experimental therapeutics 1993;265(2):649-56.
1993: Korneyev A Y; Costa E; Guidotti A
During anesthetic-induced activation of hypothalamic pituitary adrenal axis, blood-borne steroids fail to contribute to the anesthetic effect.
Neuroendocrinology 1993;57(3):559-65.
1993: Szekely A M; Grayson D; Costa E
Nuclear signal transduction via immediate early genes in neurons and glia.
Biochemical Society transactions 1993;21(1):61-5.
1993: Caruncho H J; Puia G; Slobodyansky E; da Silva P P; Costa E
Freeze-fracture immunocytochemical study of the expression of native and recombinant GABAA receptors.
Brain research 1993;603(2):234-42.
1993: Ducic I; Puia G; Vicini S; Costa E
Triazolam is more efficacious than diazepam in a broad spectrum of recombinant GABAA receptors.
European journal of pharmacology 1993;244(1):29-35.
1993: Cavallaro S; Pani L; Guidotti A; Costa E
ACTH-induced mitochondrial DBI receptor (MDR) and diazepam binding inhibitor (DBI) expression in adrenals of hypophysectomized rats is not cause-effect related to its immediate steroidogenic action.
Life sciences 1993;53(14):1137-47.
1993: Berkovich A; Ferrarese C; Cavaletti G; Alho H; Marzorati C; Bianchi G; Guidotti A; Costa E
Topology of two DBI receptors in human lymphocytes.
Life sciences 1993;52(15):1265-77.
1993: Manev H; Guidotti A; Costa E
Protection by gangliosides against glutamate excitotoxicity.
Advances in lipid research 1993;25():269-88.
1993: Puia G; Ducic I; Vicini S; Costa E
Does neurosteroid modulatory efficacy depend on GABAA receptor subunit composition?
Receptors & channels 1993;1(2):135-42.
1993: Bertolino M; Baraldi M; Parenti C; Braghiroli D; DiBella M; Vicini S; Costa E
Modulation of AMPA/kainate receptors by analogues of diazoxide and cyclothiazide in thin slices of rat hippocampus.
Receptors & channels 1993;1(4):267-78.
1993: Costa E; Armstrong D; Guidotti A; Kharlamov A; Kiedrowski L; Wroblewski J T
Ganglioside GM1 and its semisynthetic lysogangliosides reduce glutamate neurotoxicity by a novel mechanism.
Advances in experimental medicine and biology 1993;341():129-41.
1992: Cavallaro S; Korneyev A; Guidotti A; Costa E
Diazepam-binding inhibitor (DBI)-processing products, acting at the mitochondrial DBI receptor, mediate adrenocorticotropic hormone-induced steroidogenesis in rat adrenal gland.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10598-602.
1992: Bovolin P; Santi M R; Puia G; Costa E; Grayson D
Expression patterns of gamma-aminobutyric acid type A receptor subunit mRNAs in primary cultures of granule neurons and astrocytes from neonatal rat cerebella.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9344-8.
1992: De Erausquin G; Brooker G; Costa E; Wojcik W J
Stimulation of high affinity gamma-aminobutyric acidB receptors potentiates the depolarization-induced increase of intraneuronal ionized calcium content in cerebellar granule neurons.
Molecular pharmacology 1992;42(3):407-14.
1992: Romeo E; Auta J; Kozikowski A P; Ma D; Papadopoulos V; Puia G; Costa E; Guidotti A
2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).
The Journal of pharmacology and experimental therapeutics 1992;262(3):971-8.
1992: Bovolin P; Santi M R; Memo M; Costa E; Grayson D R
Distinct developmental patterns of expression of rat alpha 1, alpha 5, gamma 2S, and gamma 2L gamma-aminobutyric acidA receptor subunit mRNAs in vivo and in vitro.
Journal of neurochemistry 1992;59(1):62-72.
1992: Guarneri P; Papadopoulos V; Pan B; Costa E
Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'-chlorodiazepam.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):5118-22.
1992: Papadopoulos V; Guarneri P; Kreuger K E; Guidotti A; Costa E
Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):5113-7.
1992: Puia G; Ducic I; Vicini S; Costa E
Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at gamma-aminobutyric acid type A receptor.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3620-4.
1992: Kiedrowski L; Costa E; Wroblewski J T
Sodium nitroprusside inhibits N-methyl-D-aspartate-evoked calcium influx via a nitric oxide- and cGMP-independent mechanism.
Molecular pharmacology 1992;41(4):779-84.
1992: Olasmaa M; Guidotti A; Costa E
Vasoactive intestinal polypeptide facilitates tyrosine hydroxylase induction by cholinergic agonists in bovine adrenal chromaffin cells.
Molecular pharmacology 1992;41(3):456-64.
1992: Kiedrowski L; Costa E; Wroblewski J T
In vitro interaction between cerebellar astrocytes and granule cells: a putative role for nitric oxide.
Neuroscience letters 1992;135(1):59-61.
1992: Kiedrowski L; Costa E; Wroblewski J T
Glutamate receptor agonists stimulate nitric oxide synthase in primary cultures of cerebellar granule cells.
Journal of neurochemistry 1992;58(1):335-41.
1992: Apud J A; Grayson D R; De Erausquin E; Costa E
Pharmacological characterization of regulation of phosphoinositide metabolism by recombinant 5-HT2 receptors of the rat.
Neuropharmacology 1992;31(1):1-8.
1992: Mereu G; Costa E; Livsey C T; Vicini S
Modulation of GABAA-gated C1- currents in nigral neurons in slices.
Advances in biochemical psychopharmacology 1992;47():179-88.
1992: Puia G; Vicini S; Seeburg P H; Costa E
Different sites of action of neurosteroids and benzodiazepines on natural and recombinant GABAA receptors.
Advances in biochemical psychopharmacology 1992;47():103-10.
1992: Costa E
Partial allosteric modulation of GABAA receptor: molecular mechanisms and clinical implications.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():403A-404A.
1991: Costa E
"Prolegomena" to the biology of the diazepam binding inhibitor (DBI).
Neuropharmacology 1991;30(12B):1357-64.
1991: Kiedrowski L; Manev H; Costa E; Wroblewski J T
Inhibition of glutamate-induced cell death by sodium nitroprusside is not mediated by nitric oxide.
Neuropharmacology 1991;30(11):1241-3.
1991: Manev H; Favaron M; Siman R; Guidotti A; Costa E
Glutamate neurotoxicity is independent of calpain I inhibition in primary cultures of cerebellar granule cells.
Journal of neurochemistry 1991;57(4):1288-95.
1991: Papadopoulos V; Berkovich A; Krueger K E; Costa E; Guidotti A
Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors.
Endocrinology 1991;129(3):1481-8.
1991: Vigé X; Costa E; Wise B C
Mechanism of nerve growth factor mRNA regulation by interleukin-1 and basic fibroblast growth factor in primary cultures of rat astrocytes.
Molecular pharmacology 1991;40(2):186-92.
1991: Massotti M; Slobodyansky E; Konkel D; Costa E; Guidotti A
Regulation of diazepam binding inhibitor in rat adrenal gland by adrenocorticotropin.
Endocrinology 1991;129(2):591-6.
1991: Costa E
The Di Mascio Lecture. The allosteric modulation of GABAA receptors. Seventeen years of research.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1991;4(4):225-35.
1991: Giusti P; Guidetti G; Costa E; Guidotti A
The preferential antagonism of pentylenetetrazole proconflict responses differentiates a class of anxiolytic benzodiazepines with potential antipanic action.
The Journal of pharmacology and experimental therapeutics 1991;257(3):1062-8.
1991: Puia G; Vicini S; Seeburg P H; Costa E
Influence of recombinant gamma-aminobutyric acid-A receptor subunit composition on the action of allosteric modulators of gamma-aminobutyric acid-gated Cl- currents.
Molecular pharmacology 1991;39(6):691-6.
1991: Memo M; Bovolin P; Costa E; Grayson D R
Regulation of gamma-aminobutyric acidA receptor subunit expression by activation of N-methyl-D-aspartate-selective glutamate receptors.
Molecular pharmacology 1991;39(5):599-603.
1991: Mereu G; Costa E; Armstrong D M; Vicini S
Glutamate receptor subtypes mediate excitatory synaptic currents of dopamine neurons in midbrain slices.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(5):1359-66.
1991: Massotti M; Schlichting J L; Antonacci M D; Giusti P; Memo M; Costa E; Guidotti A
gamma-Aminobutyric acidA receptor heterogeneity in rat central nervous system: studies with clonazepam and other benzodiazepine ligands.
The Journal of pharmacology and experimental therapeutics 1991;256(3):1154-60.
1991: Fabrazzo M; Costa E; Mocchetti I
Stimulation of nerve growth factor biosynthesis in developing rat brain by reserpine: steroids as potential mediators.
Molecular pharmacology 1991;39(2):144-9.
1991: Costa E; Guidotti A
Diazepam binding inhibitor (DBI): a peptide with multiple biological actions.
Life sciences 1991;49(5):325-44.
1990: Olasmaa M; Rothstein J D; Guidotti A; Weber R J; Paul S M; Spector S; Zeneroli M L; Baraldi M; Costa E
Endogenous benzodiazepine receptor ligands in human and animal hepatic encephalopathy.
Journal of neurochemistry 1990;55(6):2015-23.
1990: Lazarewicz J W; Wroblewski J T; Costa E
N-methyl-D-aspartate-sensitive glutamate receptors induce calcium-mediated arachidonic acid release in primary cultures of cerebellar granule cells.
Journal of neurochemistry 1990;55(6):1875-81.
1990: Szekely A M; Costa E; Grayson D R
Transcriptional program coordination by N-methyl-D-aspartate-sensitive glutamate receptor stimulation in primary cultures of cerebellar neurons.
Molecular pharmacology 1990;38(5):624-33.
1990: de Erausquin G A; Manev H; Guidotti A; Costa E; Brooker G
Gangliosides normalize distorted single-cell intracellular free Ca2+ dynamics after toxic doses of glutamate in cerebellar granule cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(20):8017-21.
1990: Wojcik W J; Travagli R A; Costa E; Bertolino M
Baclofen inhibits with high affinity an L-type-like voltage-dependent calcium channel in cerebellar granule cell cultures.
Neuropharmacology 1990;29(10):969-72.
1990: Ulivi M; Costa E; Wojcik W J
Kainate receptor activation stimulate release of glutamate, alanine and glycine.
Pharmacological research : the official journal of the Italian Pharmacological Society 1990;22 Suppl 3():33-4.
1990: Yakovlev A G; De Bernardi M A; Fabrazzo M; Brooker G; Costa E; Mocchetti I
Regulation of nerve growth factor receptor mRNA content by dexamethasone: in vitro and in vivo studies.
Neuroscience letters 1990;116(1-2):216-20.
1990: Manev H; Costa E; Wroblewski J T; Guidotti A
Abusive stimulation of excitatory amino acid receptors: a strategy to limit neurotoxicity.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(10):2789-97.
1990: Guarneri P; Berkovich A; Guidotti A; Costa E
A study of diazepam binding inhibitor (DBI) processing products in human cerebrospinal fluid and in postmortem human brain.
Neuropharmacology 1990;29(5):419-28.
1990: Puia G; Santi M R; Vicini S; Pritchett D B; Purdy R H; Paul S M; Seeburg P H; Costa E
Neurosteroids act on recombinant human GABAA receptors.
Neuron 1990;4(5):759-65.
1990: Papadopoulos V; Mukhin A G; Costa E; Krueger K E
The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis.
The Journal of biological chemistry 1990;265(7):3772-9.
1990: Favaron M; Manev H; Siman R; Bertolino M; Szekely A M; DeErausquin G; Guidotti A; Costa E
Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):1983-7.
1990: Schramm M; Eimerl S; Costa E
Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: role of the glutamate receptor responsive to N-methyl-D-aspartate.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(3):1193-7.
1990: Manev H; Favaron M; De Erausquin G; Guidotti A; Brooker G; Costa E
Destabilization of ionized Ca2+ homeostasis in excitatory amino acid neurotoxicity: antagonism by glycosphingolipids.
Cell biology international reports 1990;14(1):3-14.
1990: Manev H; Favaron M; Vicini S; Guidotti A; Costa E
Glutamate-induced neuronal death in primary cultures of cerebellar granule cells: protection by synthetic derivatives of endogenous sphingolipids.
The Journal of pharmacology and experimental therapeutics 1990;252(1):419-27.
1990: Guarneri P; Guidotti A; Costa E
On the processing of diazepam binding inhibitor (DBI) in human brain.
Advances in biochemical psychopharmacology 1990;46():201-11.
1990: Danysz W; Fadda E; Wroblewski J T; Costa E
[3H]D-serine labels strychnine-insensitive glycine recognition sites of rat central nervous system.
Life sciences 1990;46(3):155-64.
1990: Guidotti A; Manev H; Favaron M; Brooker G; Costa E
Protection by natural and semisynthetic gangliosides from Ca2(+)-dependent neurotoxicity caused by excitatory amino acid (EAA) neurotransmitters.
Advances in experimental medicine and biology 1990;268():135-44.
1990: Costa E
"Spare receptors" and "partial agonists"--romantic terms to explain a pharmacology deriving from the structural diversity of GABAA receptors.
Advances in biochemical psychopharmacology 1990;46():221-30.
1989: Hynie S; Wroblewski J T; Costa E
Profile of phosphatidylinositol metabolism stimulated by carbachol and glutamate in primary cultures of rat cerebellar neurons.
Neuropharmacology 1989;28(12):1309-15.
1989: Mukhin A G; Papadopoulos V; Costa E; Krueger K E
Mitochondrial benzodiazepine receptors regulate steroid biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(24):9813-6.
1989: Danysz W; Fadda E; Wroblewski J T; Costa E
Different modes of action of 3-amino-1-hydroxy-2-pyrrolidone (HA-966) and 7-chlorokynurenic acid in the modulation of N-methyl-D-aspartate-sensitive glutamate receptors.
Molecular pharmacology 1989;36(6):912-6.
1989: Alho H; Bovolin P; Jenkins D; Guidotti A; Costa E
Cellular and subcellular localization of an octadecaneuropeptide derived from diazepam binding inhibitor: immunohistochemical studies in the rat brain.
Journal of chemical neuroanatomy 1989;2(6):301-18.
1989: Slobodyansky E; Guidotti A; Wambebe C; Berkovich A; Costa E
Isolation and characterization of a rat brain triakontatetraneuropeptide, a posttranslational product of diazepam binding inhibitor: specific action at the Ro 5-4864 recognition site.
Journal of neurochemistry 1989;53(4):1276-84.
1989: Wojcik W J; Ulivi M; Paez X; Costa E
Islet-activating protein inhibits the beta-adrenergic receptor facilitation elicited by gamma-aminobutyric acidB receptors.
Journal of neurochemistry 1989;53(3):753-8.
1989: Costa E
Allosteric modulatory centers of transmitter amino acid receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1989;2(3):167-74.
1989: Puia G; Santi M R; Vicini S; Pritchett D B; Seeburg P H; Costa E
Differences in the negative allosteric modulation of gamma-aminobutyric acid receptors elicited by 4'-chlorodiazepam and by a beta-carboline-3-carboxylate ester: a study with natural and reconstituted receptors.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):7275-9.
1989: Manev H; Favaron M; Guidotti A; Costa E
Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death.
Molecular pharmacology 1989;36(1):106-12.
1989: Mocchetti I; De Bernardi M A; Szekely A M; Alho H; Brooker G; Costa E
Regulation of nerve growth factor biosynthesis by beta-adrenergic receptor activation in astrocytoma cells: a potential role of c-Fos protein.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(10):3891-5.
1989: Wroblewski J T; Fadda E; Mazzetta J; Lazarewicz J W; Costa E
Glycine and D-serine act as positive modulators of signal transduction at N-methyl-D-aspartate sensitive glutamate receptors in cultured cerebellar granule cells.
Neuropharmacology 1989;28(5):447-52.
1989: Bertolino M; Vicini S; Costa E
Kynurenic acid inhibits the activation of kainic and N-methyl-D-aspartic acid-sensitive ionotropic receptors by a different mechanism.
Neuropharmacology 1989;28(5):453-7.
1989: Szekely A M; Barbaccia M L; Alho H; Costa E
In primary cultures of cerebellar granule cells the activation of N-methyl-D-aspartate-sensitive glutamate receptors induces c-fos mRNA expression.
Molecular pharmacology 1989;35(4):401-8.
1989: Olasmaa M; Guidotti A; Costa E; Rothstein J D; Goldman M E; Weber R J; Paul S M
Endogenous benzodiazepines in hepatic encephalopathy.
Lancet 1989;1(8636):491-2.
1989: Danysz W; Wroblewski J T; Brooker G; Costa E
Modulation of glutamate receptors by phencyclidine and glycine in the rat cerebellum: cGMP increase in vivo.
Brain research 1989;479(2):270-6.
1989: Danysz W; Fadda E; Wroblewski J T; Costa E
Kynurenate and 2-amino-5-phosphonovalerate interact with multiple binding sites of the N-methyl-D-aspartate-sensitive glutamate receptor domain.
Neuroscience letters 1989;96(3):340-4.
1989: Mocchetti I; Ritter A; Costa E
Down-regulation of proopiomelanocortin synthesis and beta-endorphin utilization in hypothalamus of morphine-tolerant rats.
Journal of molecular neuroscience : MN 1989;1(1):33-8.
1988: Fadda E; Danysz W; Wroblewski J T; Costa E
Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes.
Neuropharmacology 1988;27(11):1183-5.
1988: Favaron M; Manev H; Alho H; Bertolino M; Ferret B; Guidotti A; Costa E
Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(19):7351-5.
1988: Alho H; Fremeau R T; Tiedge H; Wilcox J; Bovolin P; Brosius J; Roberts J L; Costa E
Diazepam binding inhibitor gene expression: location in brain and peripheral tissues of rat.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(18):7018-22.
1988: DeBernardi M A; Crowe R R; Mocchetti I; Shows T B; Eddy R L; Costa E
Chromosomal localization of the human diazepam binding inhibitor gene.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(17):6561-5.
1988: Dal Toso R; De Bernardi M A; Brooker G; Costa E; Mocchetti I
Beta adrenergic and prostaglandin receptor activation increases nerve growth factor mRNA content in C6-2B rat astrocytoma cells.
The Journal of pharmacology and experimental therapeutics 1988;246(3):1190-3.
1988: Vinini S; Bertolino M; Costa E
Modulation of glutamate-activated channels in primary culture of cortical neurons.
Puerto Rico health sciences journal 1988;7(2):93-5.
1988: Lazarewicz J W; Wroblewski J T; Palmer M E; Costa E
Activation of N-methyl-D-aspartate-sensitive glutamate receptors stimulates arachidonic acid release in primary cultures of cerebellar granule cells.
Neuropharmacology 1988;27(7):765-9.
1988: Danysz W; Wroblewski J T; Costa E
Learning impairment in rats by N-methyl-D-aspartate receptor antagonists.
Neuropharmacology 1988;27(6):653-6.
1988: Nicoletti F; Wroblewski J T; Fadda E; Costa E
Pertussis toxin inhibits signal transduction at a specific metabolotropic glutamate receptor in primary cultures of cerebellar granule cells.
Neuropharmacology 1988;27(6):551-6.
1988: Naranjo J R; Wise B C; Mellstrom B; Costa E
Negative feedback regulation of the content of proenkephalin mRNA in chromaffin cell cultures.
Neuropharmacology 1988;27(4):337-43.
1988: Bertolino M; Vicini S; Mazzetta J; Costa E
Phencyclidine and glycine modulate NMDA-activated high conductance cationic channels by acting at different sites.
Neuroscience letters 1988;84(3):351-5.
1988: Costa E
The Pennsylvania State University College of Medicine. 1987 B.B. Brodie lecture "Polytypic signaling at GABAergic synapses".
Life sciences 1988;42(15):1407-17.
1988: Vicini S; Mienville J M; Costa E
Chloride channel modulation through the benzodiazepine recognition site.
Advances in biochemical psychopharmacology 1988;45():87-94.
1988: Costa E; Berkovich A; Wambebe C; Guidotti A
Terminology for ligands of the allosteric modulatory center of GABA-operated Cl- channels.
Advances in biochemical psychopharmacology 1988;45():367-74.
1987: Nicoletti F; Wroblewski J T; Alho H; Eva C; Fadda E; Costa E
Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acids.
Brain research 1987;436(1):103-12.
1987: Dal Toso R; De Bernardi M A; Costa E; Mocchetti I
Beta-adrenergic receptor regulation of NGF-mRNA content in rat C6-2B glioma cells.
Neuropharmacology 1987;26(12):1783-6.
1987: Vaccarino F; Guidotti A; Costa E
Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8707-11.
1987: Szekely A M; Barbaccia M L; Costa E
Activation of specific glutamate receptor subtypes increases C-fos proto-oncogene expression in primary cultures of neonatal rat cerebellar granule cells.
Neuropharmacology 1987;26(12):1779-82.
1987: Vicini S; Mienville J M; Costa E
Actions of benzodiazepine and beta-carboline derivatives on gamma-aminobutyric acid-activated Cl- channels recorded from membrane patches of neonatal rat cortical neurons in culture.
The Journal of pharmacology and experimental therapeutics 1987;243(3):1195-201.
1987: Szekely A M; Barbaccia M L; Costa E
Effect of a protracted antidepressant treatment on signal transduction and [3H](-)-baclofen binding at GABAB receptors.
The Journal of pharmacology and experimental therapeutics 1987;243(1):155-9.
1987: Eva C; Costa E
In rat hippocampus, somatostatin 14 and muscarinic receptor ligands modulate an adenylate cyclase belonging to a common domain of the receptor.
The Journal of pharmacology and experimental therapeutics 1987;242(3):888-94.
1987: Wroblewski J T; Nicoletti F; Fadda E; Costa E
Phencyclidine is a negative allosteric modulator of signal transduction at two subclasses of excitatory amino acid receptors.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(14):5068-72.
1987: Mocchetti I; Costa E
In vivo studies of the regulation of neuropeptide stores in structures of the rat brain.
Neuropharmacology 1987;26(7B):855-62.
1987: Ferrarese C; Alho H; Guidotti A; Costa E
Co-localization and co-release of GABA and putative allosteric modulators of GABA receptor.
Neuropharmacology 1987;26(7B):1011-8.
1987: Ferrarese C; Vaccarino F; Alho H; Mellstrom B; Costa E; Guidotti A
Subcellular location and neuronal release of diazepam binding inhibitor.
Journal of neurochemistry 1987;48(4):1093-102.
1986: Vicini S; Alho H; Costa E; Mienville J M; Santi M R; Vaccarino F M
Modulation of gamma-aminobutyric acid-mediated inhibitory synaptic currents in dissociated cortical cell cultures.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(23):9269-73.
1986: Guidotti A; Santi M R; Berkovich A; Ferrarese C; Costa E
Structure-activity relationship of peptide fragments derived from DBI (diazepam binding inhibitor), a putative endogenous ligand of benzodiazepine recognition sites.
Clinical neuropharmacology 1986;9 Suppl 4():217-9.
1986: Vicini S; Mienville J M; Costa E
Flunitrazepam action on the GABA-Cl ionophore complex in rat cortical neurons in culture: a patch-clamp study.
Clinical neuropharmacology 1986;9 Suppl 4():395-7.

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