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Max Costa

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Disorders

Cell Transformation, Neoplastic

Physiology

Cell Hypoxia

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Adriana Arita; Yana Chervona; Hailey A Clancy; Kathrin Kiok; Thomas Kluz; Alexandra Muñoz; Jingping Niu; Qingshan Qu; Ye Ruan; Magdy Y Shamy; Hong Sun; Najuan Zhao; Max Costa
Gene expression profiles in peripheral blood mononuclear cells of Chinese nickel refinery workers with high exposures to nickel and control subjects.
Oktawia P Wójcik; Anne Zeleniuch-Jacquotte; Max Costa; Karen L Koenig; Camille Pearte; Yu Chen
Serum taurine and risk of coronary heart disease: a prospective, nested case-control study.
Hong Sun; Mianhua Zhong; Mansour A Alghamdi; Lung Chi Chen; Mamdouh I Khoder; Thomas Kluz; Freda Laulicht; Alexandra B Muñoz; Magdy Shamy; Max Costa
Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia.

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All Publications

2013: Adriana Arita; Yana Chervona; Hailey A Clancy; Kathrin Kiok; Thomas Kluz; Alexandra Muñoz; Jingping Niu; Qingshan Qu; Ye Ruan; Magdy Y Shamy; Hong Sun; Najuan Zhao; Max Costa
Gene expression profiles in peripheral blood mononuclear cells of Chinese nickel refinery workers with high exposures to nickel and control subjects.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2013;22(2):261-9.
2013: Oktawia P Wójcik; Anne Zeleniuch-Jacquotte; Max Costa; Karen L Koenig; Camille Pearte; Yu Chen
Serum taurine and risk of coronary heart disease: a prospective, nested case-control study.
European journal of nutrition 2013;52(1):169-78.
2012: Hong Sun; Mianhua Zhong; Mansour A Alghamdi; Lung Chi Chen; Mamdouh I Khoder; Thomas Kluz; Freda Laulicht; Alexandra B Muñoz; Magdy Shamy; Max Costa
Gene expression profiling and pathway analysis of human bronchial epithelial cells exposed to airborne particulate matter collected from Saudi Arabia.
Toxicology and applied pharmacology 2012;265(2):147-57.
2012: Yana Chervona; Eunus Ali; Adriana Arita; Mary V Gamble; Megan N Hall; Xinhua Liu; Hong Sun; Hsiang-Chi Tseng; Mohammad Nasir Uddin; Fen Wu; Maria Antonietta Zoroddu; Max Costa
Associations between arsenic exposure and global posttranslational histone modifications among adults in Bangladesh.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2012;21(12):2252-60.
2012: Yana Chervona; Max Costa
The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals.
Free radical biology & medicine 2012;53(5):1041-7.
2012: Hailey A Clancy; Thomas Kluz; Alexandra Muñoz; Lisa Passantino; Hong Sun; Jiri Zavadil; Max Costa
Gene expression changes in human lung cells exposed to arsenic, chromium, nickel or vanadium indicate the first steps in cancer.
Metallomics : integrated biometal science 2012;4(8):784-93.
2012: Adriana Arita; Yana Chervona; Harriet A Clancy; Mary V Gamble; Megan N Hall; Qingshan Qu; Magdy Y Shamy; Hong Sun; Max Costa
The effect of exposure to carcinogenic metals on histone tail modifications and gene expression in human subjects.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2012;26(2-3):174-8.
2012: Adriana Arita; Yana Chervona; Richard B Hayes; Arthur Nadas; Jingping Niu; Qingshan Qu; Ye Ruan; Hong Sun; Fen Wu; Najuan Zhao; Max Costa
Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel.
Environmental health perspectives 2012;120(2):198-203.
2012: Yana Chervona; Max Costa
Histone modifications and cancer: biomarkers of prognosis?
American journal of cancer research 2012;2(5):589-97.
2011: Kathrin Kiok; Thomas Kluz; Hong Sun; Fen Wu; Sutapa Bose; Hailey Clancy; Max Costa
Liprin-α4 is required for nickel induced receptor protein tyrosine phosphatase-leukocyte antigen related receptor F (RPTP-LAR) activity.
PloS one 2011;6(8):e22764.
2011: Kam-Meng Tchou-Wong; Kathrin Kiok; Zuojian Tang; Thomas Kluz; Adriana Arita; Phillip R Smith; Stuart Brown; Max Costa
Effects of nickel treatment on H3K4 trimethylation and gene expression.
PloS one 2011;6(3):e17728.
2011: Hong Sun; Harriet A Clancy; Thomas Kluz; Jiri Zavadil; Max Costa
Comparison of gene expression profiles in chromate transformed BEAS-2B cells.
PloS one 2011;6(3):e17982.
2010: Dazhong Xu; Yixin Yao; Luo Lu; Max Costa; Wei Dai
Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha.
The Journal of biological chemistry 2010;285(50):38944-50.
2010: Haobin Chen; Thomas Kluz; Ronghe Zhang; Max Costa
Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells.
Carcinogenesis 2010;31(12):2136-44.
2010: Shang Wang; Colette Prophete; Joleen M Soukup; Lung Chi Chen; Max Costa; Andrew Ghio; Qingshan Qu; Mitchell D Cohen; Haobin Chen
Roles of MAPK pathway activation during cytokine induction in BEAS-2B cells exposed to fine World Trade Center (WTC) dust.
Journal of immunotoxicology 2010;7(4):298-307.
2010: Jennifer Wu; Charles Henderson; Lynn Feun; Peter Van Veldhuizen; Philip Gold; Hui Zheng; Theresa Ryan; Lawrence S Blaszkowsky; Haobin Chen; Max Costa; Barry Rosenzweig; MaryLynn Nierodzik; Howard Hochster; Franco Muggia; Giovanni Abbadessa; Jonathan Lewis; Andrew X Zhu
Phase II study of darinaparsin in patients with advanced hepatocellular carcinoma.
Investigational new drugs 2010;28(5):670-6.
2010: Oktawia P Wójcik; Karen L Koenig; Anne Zeleniuch-Jacquotte; Max Costa; Yu Chen
Temporal reproducibility of taurine measurements in frozen serum of healthy postmenopausal women.
The British journal of nutrition 2010;104(5):629-32.
2010: Xue Zhou; Hong Sun; Haobin Chen; Jiri Zavadil; Thomas Kluz; Adriana Arita; Max Costa
Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase.
Cancer research 2010;70(10):4214-21.
2010: Haobin Chen; Nitai Charan Giri; Ronghe Zhang; Kenichi Yamane; Yi Zhang; Michael Maroney; Max Costa
Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers.
The Journal of biological chemistry 2010;285(10):7374-83.
2010: Maria Antonietta Zoroddu; massimiliano peana; Serenella Medici; Luigi Casella; Enrico Monzani; Max Costa
Nickel binding to histone H4.
Dalton transactions (Cambridge, England : 2003) 2010;39(3):787-93.
2010: Dongyun Zhang; Jingxia Li; Max Costa; Jimin Gao; Chuanshu Huang
JNK1 mediates degradation HIF-1alpha by a VHL-independent mechanism that involves the chaperones Hsp90/Hsp70.
Cancer research 2010;70(2):813-23.
2010: Jonathan Eckard; Jisen Dai; Jing Wu; Jinlong Jian; Qing Yang; Haobin Chen; Max Costa; Krystyna Frenkel; Xi Huang
Effects of cellular iron deficiency on the formation of vascular endothelial growth factor and angiogenesis. Iron deficiency and angiogenesis.
Cancer cell international 2010;10():28.
2010: Oktawia P Wójcik; Karen L Koenig; Anne Zeleniuch-Jacquotte; Max Costa; Yu Chen
The potential protective effects of taurine on coronary heart disease.
Atherosclerosis 2010;208(1):19-25.
2009: Dazhong Xu; Jingxiang Bai; Qing Duan; Max Costa; Wei Dai
Covalent modifications of histones during mitosis and meiosis.
Cell cycle (Georgetown, Tex.) 2009;8(22):3688-94.
2009: Xue Zhou; Adriana Arita; Thomas P Ellen; Xin Liu; Jingxiang Bai; John P Rooney; Adrienne D Kurtz; Catherine B Klein; Wei Dai; Thomas J Begley; Max Costa
A genome-wide screen in Saccharomyces cerevisiae reveals pathways affected by arsenic toxicity.
Genomics 2009;94(5):294-307.
2009: Qin Li; Qingdong Ke; Max Costa
Alterations of histone modifications by cobalt compounds.
Carcinogenesis 2009;30(7):1243-51.
2009: Hong Sun; Xue Zhou; Haobin Chen; Qin Li; Max Costa
Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium.
Toxicology and applied pharmacology 2009;237(3):258-66.
2009: Thomas P Ellen; Thomas Kluz; Mark E Harder; Judy Xiong; Max Costa
Heterochromatinization as a potential mechanism of nickel-induced carcinogenesis.
Biochemistry 2009;48(21):4626-32.
2009: Xue Zhou; Qin Li; Adriana Arita; Hong Sun; Max Costa
Effects of nickel, chromate, and arsenite on histone 3 lysine methylation.
Toxicology and applied pharmacology 2009;236(1):78-84.
2009: Haobin Chen; Max Costa
Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2009;22(1):191-6.
2009: Adriana Arita; Max Costa
Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium.
Metallomics : integrated biometal science 2009;1(3):222-8.
2009: Qin Li; Thomas Kluz; Hong Sun; Max Costa
Mechanisms of c-myc degradation by nickel compounds and hypoxia.
PloS one 2009;4(12):e8531.
2009: Weiming Ouyang; Dongyun Zhang; Jingxia Li; Udit N Verma; Max Costa; Chuanshu Huang
Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 down-regulation.
Journal of cellular physiology 2009;218(1):205-14.
2008: Qing Duan; Haobin Chen; Max Costa; Wei Dai
Phosphorylation of H3S10 blocks the access of H3K9 by specific antibodies and histone methyltransferase. Implication in regulating chromatin dynamics and epigenetic inheritance during mitosis.
The Journal of biological chemistry 2008;283(48):33585-90.
2008: Xue Zhou; Hong Sun; Thomas P Ellen; Haobin Chen; Max Costa
Arsenite alters global histone H3 methylation.
Carcinogenesis 2008;29(9):1831-6.
2008: Qingshan Qu; Xiaomei Li; Feiyun An; Guang Jia; Lanzeng Liu; Hiroko Watanabe-Meserve; Karen Koenig; Beverly Cohen; Max Costa; Nirmal Roy; Mianhua Zhong; Lung Chi Chen; Suhua Liu; Lei Yan
CrVI exposure and biomarkers: Cr in erythrocytes in relation to exposure and polymorphisms of genes encoding anion transport proteins.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2008;13(5):467-77.
2008: Yali Yang; Jingxiang Bai; Ruoqian Shen; Sharron A N Brown; Elena Komissarova; Ying Huang; Ning Jiang; Gregory F Alberts; Max Costa; Luo Lu; Jeffrey A Winkles; Wei Dai
Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions.
Cancer research 2008;68(11):4077-85.
2008: Qingdong Ke; Qin Li; Thomas P Ellen; Hong Sun; Max Costa
Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway.
Carcinogenesis 2008;29(6):1276-81.
2008: Qingdong Ke; Thomas P Ellen; Max Costa
Nickel compounds induce histone ubiquitination by inhibiting histone deubiquitinating enzyme activity.
Toxicology and applied pharmacology 2008;228(2):190-9.
2008: Thomas P Ellen; Qingdong Ke; Ping Zhang; Max Costa
NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states.
Carcinogenesis 2008;29(1):2-8.
2007: Ping Zhang; Kam-Meng Tchou-Wong; Max Costa
Egr-1 mediates hypoxia-inducible transcription of the NDRG1 gene through an overlapping Egr-1/Sp1 binding site in the promoter.
Cancer research 2007;67(19):9125-33.
2007: Ahmed N Uddin; Fredric J Burns; Toby G Rossman; Haobin Chen; Thomas Kluz; Max Costa
Dietary chromium and nickel enhance UV-carcinogenesis in skin of hairless mice.
Toxicology and applied pharmacology 2007;221(3):329-38.
2007: Minori Koshiji; Kensuke Kumamoto; Keiichirou Morimura; Yasufumi Utsumi; Michiko Aizawa; Masami Hoshino; Shinji Ohki; Seiichi Takenoshita; Max Costa; Thérèse Commes; David Piquemal; Curtis-C Harris; Kam-Meng Tchou-Wong
Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity.
World journal of gastroenterology : WJG 2007;13(20):2803-10.
2007: Dongyun Zhang; Jingxia Li; Kangjian Wu; Weiming Ouyang; Jin Ding; Zheng-gang Liu; Max Costa; Chuanshu Huang
JNK1, but not JNK2, is required for COX-2 induction by nickel compounds.
Carcinogenesis 2007;28(4):883-91.
2007: Qingdong Ke; Todd Davidson; Thomas Kluz; Adriana Oller; Max Costa
Fluorescent tracking of nickel ions in human cultured cells.
Toxicology and applied pharmacology 2007;219(1):18-23.
2006: Jin Ding; Xinhai Zhang; Jingxia Li; Lun Song; Weiming Ouyang; Dongyun Zhang; Caifang Xue; Max Costa; J Andrés Meléndez; Chuanshu Huang
Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKKalpha- and p50-independent pathway.
The Journal of biological chemistry 2006;281(51):39022-32.
2006: Gi Soo Kang; Qin Li; Haobin Chen; Max Costa
Effect of metal ions on HIF-1alpha and Fe homeostasis in human A549 cells.
Mutation research 2006;610(1-2):48-55.
2006: Qingdong Ke; Max Costa
Hypoxia-inducible factor-1 (HIF-1).
Molecular pharmacology 2006;70(5):1469-80.
2006: Haobin Chen; Max Costa
Effect of soluble nickel on cellular energy metabolism in A549 cells.
Experimental biology and medicine (Maywood, N.J.) 2006;231(9):1474-80.
2006: Haobin Chen; Yan Yan; Todd L Davidson; Yoichi Shinkai; Max Costa
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells.
Cancer research 2006;66(18):9009-16.
2006: Qingdong Ke; Jingxia Li; Jin Ding; Min Ding; Liying Wang; Bingci Liu; Max Costa; Chuanshu Huang
Essential role of ROS-mediated NFAT activation in TNF-alpha induction by crystalline silica exposure.
American journal of physiology. Lung cellular and molecular physiology 2006;291(2):L257-64.
2006: Todd L Davidson; Haobin Chen; Dominic M Di Toro; Gisela D'Angelo; Max Costa
Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells.
Molecular carcinogenesis 2006;45(7):479-89.
2006: Qingdong Ke; Todd Davidson; Haobin Chen; Thomas Kluz; Max Costa
Alterations of histone modifications and transgene silencing by nickel chloride.
Carcinogenesis 2006;27(7):1481-8.
2006: Qin Li; Haobin Chen; Xi Huang; Max Costa
Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes.
Toxicology and applied pharmacology 2006;213(3):245-55.
2006: Haobin Chen; Qingdong Ke; Thomas Kluz; Yan Yan; Max Costa
Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing.
Molecular and cellular biology 2006;26(10):3728-37.
2006: Max Costa; Catherine B Klein
Toxicity and carcinogenicity of chromium compounds in humans.
Critical reviews in toxicology 2006;36(2):155-63.
2006: Jing Wu; Jonathan Eckard; Haobin Chen; Max Costa; Krystyna Frenkel; Xi Huang
Altered iron homeostasis involvement in arsenite-mediated cell transformation.
Free radical biology & medicine 2006;40(3):444-52.
2006: Michael D Garrick; Steven Singleton; Farida Vargas; Hung-Chieh Kuo; Lin Zhao; Martin Knöpfel; Todd Davidson; Max Costa; Prasad N Paradkar; Jerome A Roth; Laura M Garrick
DMT1: which metals does it transport?
Biological research 2006;39(1):79-85.
2005: Max Costa; Todd L Davidson; Haobin Chen; Qingdong Ke; Ping Zhang; Yan Yan; Chuanshu Huang; Thomas Kluz
Nickel carcinogenesis: epigenetics and hypoxia signaling.
Mutation research 2005;592(1-2):79-88.
2005: Todd Davidson; Haobin Chen; Michael D Garrick; Gisela D'Angelo; Max Costa
Soluble nickel interferes with cellular iron homeostasis.
Molecular and cellular biochemistry 2005;279(1-2):157-62.
2005: Haitian Lu; Xianglin Shi; Max Costa; Chuanshu Huang
Carcinogenic effect of nickel compounds.
Molecular and cellular biochemistry 2005;279(1-2):45-67.
2005: Weiming Ouyang; Jingxia Li; Xianglin Shi; Max Costa; Chuanshu Huang
Essential role of PI-3K, ERKs and calcium signal pathways in nickel-induced VEGF expression.
Molecular and cellular biochemistry 2005;279(1-2):35-43.
2005: Jingxia Li; Qiangsong Tong; Xianglin Shi; Max Costa; Chuanshu Huang
ERKs activation and calcium signaling are both required for VEGF induction by vanadium in mouse epidermal Cl41 cells.
Molecular and cellular biochemistry 2005;279(1-2):25-33.
2005: Haobin Chen; Todd Davidson; Steven Singleton; Michael D Garrick; Max Costa
Nickel decreases cellular iron level and converts cytosolic aconitase to iron-regulatory protein 1 in A549 cells.
Toxicology and applied pharmacology 2005;206(3):275-87.
2005: Qingdong Ke; Thomas Kluz; Max Costa
Down-regulation of the expression of the FIH-1 and ARD-1 genes at the transcriptional level by nickel and cobalt in the human lung adenocarcinoma A549 cell line.
International journal of environmental research and public health 2005;2(1):10-3.
2004: Jingxia Li; Haobin Chen; Qingdong Ke; Zhaohui Feng; Moon-shong Tang; Bingci Liu; Shantu Amin; Max Costa; Chuanshu Huang
Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells.
Molecular carcinogenesis 2004;40(2):104-15.
2004: Maria Antonietta Zoroddu; massimiliano peana; Teresa Kowalik-Jankowska; Henryk Kozlowski; Max Costa
Nickel(II) binding to Cap43 protein fragments.
Journal of inorganic biochemistry 2004;98(6):931-9.
2004: Todd Davidson; Thomas Kluz; Fredric J Burns; Toby G Rossman; Qunwei Zhang; Ahmed N Uddin; Arthur Nadas; Max Costa
Exposure to chromium (VI) in the drinking water increases susceptibility to UV-induced skin tumors in hairless mice.
Toxicology and applied pharmacology 2004;196(3):431-7.
2004: Jianhua Zhao; Haobin Chen; Todd Davidson; Thomas Kluz; Qunwei Zhang; Max Costa
Nickel-induced 1,4-alpha-glucan branching enzyme 1 up-regulation via the hypoxic signaling pathway.
Toxicology and applied pharmacology 2004;196(3):404-9.
2004: Jingxia Li; Haobin Chen; Moon-shong Tang; Xianglin Shi; Shantu Amin; Dhimant Desai; Max Costa; Chuanshu Huang
PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells.
The Journal of cell biology 2004;165(1):77-86.
2004: Jingxia Li; Sujatha Dokka; Liying Wang; Xianglin Shi; Vincent Castranova; Yan Yan; Max Costa; Chuanshu Huang
Activation of aPKC is required for vanadate-induced phosphorylation of protein kinase B (Akt), but not p70S6k in mouse epidermal JB6 cells.
Molecular and cellular biochemistry 2004;255(1-2):217-25.
2004: Chuanshu Huang; Qingdong Ke; Max Costa; Xianglin Shi
Molecular mechanisms of arsenic carcinogenesis.
Molecular and cellular biochemistry 2004;255(1-2):57-66.
2004: Robert P Caruso; Benjamin Levinson; Jonathan Melamed; Rosemary Wieczorek; Samir Taneja; David Polsky; Caroline Chang; Anne Zeleniuch-Jacquotte; Konstantin Salnikow; Herman Yee; Max Costa; Iman Osman
Altered N-myc downstream-regulated gene 1 protein expression in African-American compared with caucasian prostate cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(1 Pt 1):222-7.
2004: Jingxia Li; Gerard Davidson; Yi Huang; Bing-Hua Jiang; Xianglin Shi; Max Costa; Chuanshu Huang
Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells.
Cancer research 2004;64(1):94-101.
2004: Jianhua Zhao; Yan Yan; Konstantin Salnikow; Thomas Kluz; Max Costa
Nickel-induced down-regulation of serpin by hypoxic signaling.
Toxicology and applied pharmacology 2004;194(1):60-8.
2003: Todd Davidson; Konstantin Salnikow; Max Costa
Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel.
Molecular pharmacology 2003;64(6):1485-93.
2003: Qunwei Zhang; Konstantin Salnikow; Thomas Kluz; Lung Chi Chen; WC Su; Max Costa
Inhibition and reversal of nickel-induced transformation by the histone deacetylase inhibitor trichostatin A.
Toxicology and applied pharmacology 2003;192(3):201-11.
2003: Yan Yan; Thomas Kluz; Ping Zhang; Hao-bin Chen; Max Costa
Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure.
Toxicology and applied pharmacology 2003;190(3):272-7.
2003: Konstantin Salnikow; Todd Davidson; Qunwei Zhang; Lung Chi Chen; WC Su; Max Costa
The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis.
Cancer research 2003;63(13):3524-30.
2003: Max Costa; Yan Yan; Daoji Zhao; Konstantin Salnikow
Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling.
Journal of environmental monitoring : JEM 2003;5(2):222-3.
2003: Konstantin Salnikow; Todd Davidson; Thomas Kluz; Haobin Chen; Daoji Zhou; Max Costa
GeneChip analysis of signaling pathways effected by nickel.
Journal of environmental monitoring : JEM 2003;5(2):206-9.
2003: Zhaohui Feng; Wenwei Hu; William N Rom; Max Costa; Moon-shong Tang
Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells.
Carcinogenesis 2003;24(4):771-8.
2002: Chuanshu Huang; Jingxia Li; Qingdong Ke; Stephen S Leonard; Bing-Hua Jiang; Xiao-Song Zhong; Max Costa; Vincent Castranova; Xianglin Shi
Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C.
Cancer research 2002;62(20):5689-97.
2002: Hakan Cangul; Konstantin Salnikow; Herman Yee; David Zagzag; Thérèse Commes; Max Costa
Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells.
Environmental health perspectives 2002;110 Suppl 5():783-8.
2002: Konstantin Salnikow; Todd Davidson; Max Costa
The role of hypoxia-inducible signaling pathway in nickel carcinogenesis.
Environmental health perspectives 2002;110 Suppl 5():831-4.
2002: Maria Antonietta Zoroddu; Laura Schinocca; Teresa Kowalik-Jankowska; Henryk Kozlowski; Konstantin Salnikow; Max Costa
Molecular mechanisms in nickel carcinogenesis: modeling Ni(II) binding site in histone H4.
Environmental health perspectives 2002;110 Suppl 5():719-23.
2002: Max Costa
Molecular mechanisms of nickel carcinogenesis.
Biological chemistry 2002;383(6):961-7.
2002: Max Costa; Konstantin Salnikow; Jessica E Sutherland; Limor Broday; Wu Peng; Qunwei Zhang; Thomas Kluz
The role of oxidative stress in nickel and chromate genotoxicity.
Molecular and cellular biochemistry 2002;234-235(1-2):265-75.
2002: Qunwei Zhang; Thomas Kluz; Konstantin Salnikow; Max Costa
Comparison of the cytotoxicity, cellular uptake, and DNA-protein crosslinks induced by potassium chromate in lymphoblast cell lines derived from three different individuals.
Biological trace element research 2002;86(1):11-22.
2002: Konstantin Salnikow; Thomas Kluz; Max Costa; David Piquemal; Zoya N Demidenko; Keping Xie; Mikhail V Blagosklonny
The regulation of hypoxic genes by calcium involves c-Jun/AP-1, which cooperates with hypoxia-inducible factor 1 in response to hypoxia.
Molecular and cellular biology 2002;22(6):1734-41.
2002: Hakan Cangul; Limor Broday; Konstantin Salnikow; J Sutherland; Wu Peng; Qunwei Zhang; V Poltaratsky; Herman Yee; Maria Antonietta Zoroddu; Max Costa
Molecular mechanisms of nickel carcinogenesis.
Toxicology letters 2002;127(1-3):69-75.
2002: Hakan Cangul; Konstantin Salnikow; Herman Yee; David Zagzag; Thérèse Commes; Max Costa
Enhanced expression of a novel protein in human cancer cells: a potential aid to cancer diagnosis.
Cell biology and toxicology 2002;18(2):87-96.
2001: Chuanshu Huang; Jingxia Li; Max Costa; Z Zhang; Stephen S Leonard; Vincent Castranova; Val Vallyathan; G Ju; Xianglin Shi
Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide.
Cancer research 2001;61(22):8051-7.
2001: Jessica E Sutherland; Wu Peng; Qunwei Zhang; Max Costa
The histone deacetylase inhibitor trichostatin A reduces nickel-induced gene silencing in yeast and mammalian cells.
Mutation research 2001;479(1-2):225-33.
2001: Chuanshu Huang; Jingxia Li; M Ding; Liying Wang; Xianglin Shi; Vincent Castranova; Val Vallyathan; G Ju; Max Costa
Arsenic-induced NFkappaB transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells.
Molecular and cellular biochemistry 2001;222(1-2):29-34.
2001: Max Costa; Jessica E Sutherland; Wu Peng; Konstantin Salnikow; Limor Broday; Thomas Kluz
Molecular biology of nickel carcinogenesis.
Molecular and cellular biochemistry 2001;222(1-2):205-11.
2001: Chuanshu Huang; Qunwei Zhang; Jingxia Li; Xianglin Shi; Vincent Castranova; G Ju; Max Costa; Z Dong
Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo.
Molecular and cellular biochemistry 2001;222(1-2):141-7.
2001: Chuanshu Huang; Jingxia Li; M Ding; Max Costa; Vincent Castranova; Val Vallyathan; G Ju; Xianglin Shi
Transactivation of RARE and GRE in the cellular response to arsenic.
Molecular and cellular biochemistry 2001;222(1-2):119-25.
2001: Limor Broday; Max Costa
Detecting epigenetic changes: DNA methylation.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2001;Chapter 3():Unit3.6.
2001: Jessica E Sutherland; Max Costa
Assays for DNA damage.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2001;Chapter 3():Unit3.5.
2001: Max Costa; Jessica E Sutherland
Cell transformation assays.
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2001;Chapter 3():Unit3.4.
2001: Maria Antonietta Zoroddu; Teresa Kowalik-Jankowska; Henryk Kozlowski; Konstantin Salnikow; Max Costa
Ni(II) and Cu(II) binding with a 14-aminoacid sequence of Cap43 protein, TRSRSHTSEGTRSR.
Journal of inorganic biochemistry 2001;84(1-2):47-54.
2000: Konstantin Salnikow; Max Costa; W D Figg; Mikhail V Blagosklonny
Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer.
Cancer research 2000;60(20):5630-4.
2000: Maria Antonietta Zoroddu; Teresa Kowalik-Jankowska; Henryk Kozlowski; H Molinari; Konstantin Salnikow; Limor Broday; Max Costa
Interaction of Ni(II) and Cu(II) with a metal binding sequence of histone H4: AKRHRK, a model of the H4 tail.
Biochimica et biophysica acta 2000;1475(2):163-8.
2000: Konstantin Salnikow; WC Su; Mikhail V Blagosklonny; Max Costa
Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism.
Cancer research 2000;60(13):3375-8.
2000: Jessica E Sutherland; Anatoly Zhitkovich; Thomas Kluz; Max Costa
Rats retain chromium in tissues following chronic ingestion of drinking water containing hexavalent chromium.
Biological trace element research 2000;74(1):41-53.
2000: Limor Broday; Wu Peng; M H Kuo; Konstantin Salnikow; Maria Antonietta Zoroddu; Max Costa
Nickel compounds are novel inhibitors of histone H4 acetylation.
Cancer research 2000;60(2):238-41.
2000: Konstantin Salnikow; Max Costa
Epigenetic mechanisms of nickel carcinogenesis.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 2000;19(3):307-18.
2000: Konstantin Salnikow; Mikhail V Blagosklonny; H Ryan; R Johnson; Max Costa
Carcinogenic nickel induces genes involved with hypoxic stress.
Cancer research 2000;60(1):38-41.
1999: Konstantin Salnikow; Thomas Kluz; Max Costa
Role of Ca(2+) in the regulation of nickel-inducible Cap43 gene expression.
Toxicology and applied pharmacology 1999;160(2):127-32.
1999: Konstantin Salnikow; Won G An; Giovanni Melillo; Mikhail V Blagosklonny; Max Costa
Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors.
Carcinogenesis 1999;20(9):1819-23.
1999: Limor Broday; J Cai; Max Costa
Nickel enhances telomeric silencing in Saccharomyces cerevisiae.
Mutation research 1999;440(2):121-30.
1999: Limor Broday; Y W Lee; Max Costa
5-azacytidine induces transgene silencing by DNA methylation in Chinese hamster cells.
Molecular and cellular biology 1999;19(4):3198-204.
1998: Anatoly Zhitkovich; V Voitkun; Thomas Kluz; Max Costa
Utilization of DNA-protein cross-links as a biomarker of chromium exposure.
Environmental health perspectives 1998;106 Suppl 4():969-74.
1998: Y W Lee; Limor Broday; Max Costa
Effects of nickel on DNA methyltransferase activity and genomic DNA methylation levels.
Mutation research 1998;415(3):213-8.
1998: D Zhou; Konstantin Salnikow; Max Costa
Cap43, a novel gene specifically induced by Ni2+ compounds.
Cancer research 1998;58(10):2182-9.
1998: V Voitkun; Anatoly Zhitkovich; Max Costa
Cr(III)-mediated crosslinks of glutathione or amino acids to the DNA phosphate backbone are mutagenic in human cells.
Nucleic acids research 1998;26(8):2024-30.
1998: Max Costa
Carcinogenic metals.
Science progress 1998;81 ( Pt 4)():329-39.
1997: Konstantin Salnikow; S Wang; Max Costa
Induction of activating transcription factor 1 by nickel and its role as a negative regulator of thrombospondin I gene expression.
Cancer research 1997;57(22):5060-6.
1997: Max Costa
Toxicity and carcinogenicity of Cr(VI) in animal models and humans.
Critical reviews in toxicology 1997;27(5):431-42.
1997: Max Costa; Anatoly Zhitkovich; M Harris; D Paustenbach; M Gargas
DNA-protein cross-links produced by various chemicals in cultured human lymphoma cells.
Journal of toxicology and environmental health 1997;50(5):433-49.
1997: Catherine B Klein; Max Costa
DNA methylation, heterochromatin and epigenetic carcinogens.
Mutation research 1997;386(2):163-80.
1997: Catherine B Klein; Max Costa
DNA methylation and gene expression: introduction and overview.
Mutation research 1997;386(2):103-5.
1996: Max Costa; Anatoly Zhitkovich; Paolo Toniolo; Emanuela Taioli; Todor A Popov; A Lukanova
Monitoring human lymphocytic DNA-protein cross-links as biomarkers of biologically active doses of chromate.
Environmental health perspectives 1996;104 Suppl 5():917-9.
1996: J Kitahara; K Yamanaka; K Kato; Y W Lee; Catherine B Klein; Max Costa
Mutagenicity of cobalt and reactive oxygen producers.
Mutation research 1996;370(3-4):133-40.
1996: Max Costa; Paola Bellosta; Claudio Basilico
Cleavage and release of a soluble form of the receptor tyrosine kinase ARK in vitro and in vivo.
Journal of cellular physiology 1996;168(3):737-44.
1996: Max Costa; Anatoly Zhitkovich; M Gargas; Dennis J Paustenbach; Brent L Finley; J Kuykendall; R Billings; T J Carlson; K Wetterhahn; J Xu; S Patierno; M Bogdanffy
Interlaboratory validation of a new assay for DNA-protein crosslinks.
Mutation research 1996;369(1-2):13-21.
1996: Anatoly Zhitkovich; V Voitkun; Max Costa
Formation of the amino acid-DNA complexes by hexavalent and trivalent chromium in vitro: importance of trivalent chromium and the phosphate group.
Biochemistry 1996;35(22):7275-82.
1996: Wieslaw K Dowjat; X Huang; S Cosentino; Max Costa
Peroxidase deficiency of nickel-transformed hamster cells correlates with their increased resistance to cytotoxicity of peroxides.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 1996;9(2):151-6.
1996: A Lukanova; Paolo Toniolo; Anatoly Zhitkovich; V Nikolova; Teodor Panev; Todor A Popov; Emanuela Taioli; Max Costa
Occupational exposure to Cr(VI): comparison between chromium levels in lymphocytes, erythrocytes, and urine.
International archives of occupational and environmental health 1996;69(1):39-44.
1995: Emanuela Taioli; Anatoly Zhitkovich; P Kinney; Iris Udasin; Paolo Toniolo; Max Costa
Increased DNA-protein crosslinks in lymphocytes of residents living in chromium-contaminated areas.
Biological trace element research 1995;50(3):175-80.
1995: X Huang; J Kitahara; Anatoly Zhitkovich; K Dowjat; Max Costa
Heterochromatic proteins specifically enhance nickel-induced 8-oxo-dG formation.
Carcinogenesis 1995;16(8):1753-9.
1995: Y W Lee; Catherine B Klein; B Kargacin; Konstantin Salnikow; J Kitahara; K Dowjat; Anatoly Zhitkovich; N T Christie; Max Costa
Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens.
Molecular and cellular biology 1995;15(5):2547-57.
1995: Anatoly Zhitkovich; V Voitkun; Max Costa
Glutathione and free amino acids form stable complexes with DNA following exposure of intact mammalian cells to chromate.
Carcinogenesis 1995;16(4):907-13.
1995: Paola Bellosta; Max Costa; D A Lin; Claudio Basilico
The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding.
Molecular and cellular biology 1995;15(2):614-25.
1994: Konstantin Salnikow; M Gao; V Voitkun; X Huang; Max Costa
Altered oxidative stress responses in nickel-resistant mammalian cells.
Cancer research 1994;54(24):6407-12.
1994: Catherine B Klein; B Kargacin; L Su; S Cosentino; E T Snow; Max Costa
Metal mutagenesis in transgenic Chinese hamster cell lines.
Environmental health perspectives 1994;102 Suppl 3():63-7.
1994: Z Zhuang; Max Costa
Development of an 125I-postlabeling assay as a simple, rapid, and sensitive index of DNA-protein cross-links.
Environmental health perspectives 1994;102 Suppl 3():301-4.
1994: X Lin; Max Costa
Transformation of human osteoblasts to anchorage-independent growth by insoluble nickel particles.
Environmental health perspectives 1994;102 Suppl 3():289-92.
1994: X Huang; Z Zhuang; Krystyna Frenkel; Catherine B Klein; Max Costa
The role of nickel and nickel-mediated reactive oxygen species in the mechanism of nickel carcinogenesis.
Environmental health perspectives 1994;102 Suppl 3():281-4.
1994: V Voitkun; Anatoly Zhitkovich; Max Costa
Complexing of amino acids to DNA by chromate in intact cells.
Environmental health perspectives 1994;102 Suppl 3():251-5.
1994: Max Costa; Konstantin Salnikow; S Cosentino; Catherine B Klein; X Huang; Z Zhuang
Molecular mechanisms of nickel carcinogenesis.
Environmental health perspectives 1994;102 Suppl 3():127-30.
1994: Max Costa; Z Zhuang; X Huang; S Cosentino; Catherine B Klein; Konstantin Salnikow
Molecular mechanisms of nickel carcinogenesis.
The Science of the total environment 1994;148(2-3):191-9.
1994: Z Zhuang; X Huang; Max Costa
Protein oxidation and amino acid-DNA crosslinking by nickel compounds in intact cultured cells.
Toxicology and applied pharmacology 1994;126(2):319-25.
1994: X Lin; Wieslaw K Dowjat; Max Costa
Nickel-induced transformation of human cells causes loss of the phosphorylation of the retinoblastoma protein.
Cancer research 1994;54(10):2751-4.
1994: X Huang; Catherine B Klein; Max Costa
Crystalline Ni3S2 specifically enhances the formation of oxidants in the nuclei of CHO cells as detected by dichlorofluorescein.
Carcinogenesis 1994;15(3):545-8.
1994: Emanuela Taioli; P Kinney; Anatoly Zhitkovich; H Fulton; V Voitkun; G Cosma; Krystyna Frenkel; Paolo Toniolo; Seymour Garte; Max Costa
Application of reliability models to studies of biomarker validation.
Environmental health perspectives 1994;102(3):306-9.
1994: Konstantin Salnikow; S Cosentino; C Klein; Max Costa
Loss of thrombospondin transcriptional activity in nickel-transformed cells.
Molecular and cellular biology 1994;14(1):851-8.
1993: Max Costa; Anatoly Zhitkovich; Emanuela Taioli; Paolo Toniolo
Preliminary report on a simple new assay for DNA-protein cross-links as a biomarker of exposures experienced by welders.
Journal of toxicology and environmental health 1993;40(2-3):217-22.
1993: B Kargacin; Catherine B Klein; Max Costa
Mutagenic responses of nickel oxides and nickel sulfides in Chinese hamster V79 cell lines at the xanthine-guanine phosphoribosyl transferase locus.
Mutation research 1993;300(1):63-72.
1993: X Huang; Krystyna Frenkel; Catherine B Klein; Max Costa
Nickel induces increased oxidants in intact cultured mammalian cells as detected by dichlorofluorescein fluorescence.
Toxicology and applied pharmacology 1993;120(1):29-36.
1993: Max Costa; Anatoly Zhitkovich; Paolo Toniolo
DNA-protein cross-links in welders: molecular implications.
Cancer research 1993;53(3):460-3.
1993: Paolo Toniolo; Anatoly Zhitkovich; Max Costa
Development and utilization of a new simple assay for DNA-protein crosslinks as a biomarker of exposure to welding fumes.
International archives of occupational and environmental health 1993;65(1 Suppl):S87-9.
1993: Mitchell D Cohen; B Kargacin; Catherine B Klein; Max Costa
Mechanisms of chromium carcinogenicity and toxicity.
Critical reviews in toxicology 1993;23(3):255-81.
1993: Max Costa
Molecular targets of nickel and chromium in human and experimental systems.
Scandinavian journal of work, environment & health 1993;19 Suppl 1():71-4.
1992: Konstantin Salnikow; Anatoly Zhitkovich; Max Costa
Analysis of the binding sites of chromium to DNA and protein in vitro and in intact cells.
Carcinogenesis 1992;13(12):2341-6.
1992: X Lin; Z Zhuang; Max Costa
Analysis of residual amino acid--DNA crosslinks induced in intact cells by nickel and chromium compounds.
Carcinogenesis 1992;13(10):1763-8.
1992: Mitchell D Cohen; Catherine B Klein; Max Costa
Forward mutations and DNA-protein crosslinks induced by ammonium metavanadate in cultured mammalian cells.
Mutation research 1992;269(1):141-8.
1992: Anatoly Zhitkovich; Max Costa
A simple, sensitive assay to detect DNA-protein crosslinks in intact cells and in vivo.
Carcinogenesis 1992;13(8):1485-9.
1992: X W Wang; X Lin; Catherine B Klein; R K Bhamra; Y W Lee; Max Costa
A conserved region in human and Chinese hamster X chromosomes can induce cellular senescence of nickel-transformed Chinese hamster cell lines.
Carcinogenesis 1992;13(4):555-61.
1991: Y Chen; Mitchell D Cohen; E T Snow; Max Costa
Alteration in restriction enzyme digestion patterns detects DNA--protein complexes induced by chromate.
Carcinogenesis 1991;12(9):1575-80.
1991: X H Lin; M Sugiyama; Max Costa
Differences in the effect of vitamin E on nickel sulfide or nickel chloride-induced chromosomal aberrations in mammalian cells.
Mutation research 1991;260(2):159-64.
1991: T P Coogan; J Motz; C A Snyder; Katherine S Squibb; Max Costa
Differential DNA-protein crosslinking in lymphocytes and liver following chronic drinking water exposure of rats to potassium chromate.
Toxicology and applied pharmacology 1991;109(1):60-72.
1991: Max Costa
DNA-protein complexes induced by chromate and other carcinogens.
Environmental health perspectives 1991;92():45-52.
1991: T P Coogan; Katherine S Squibb; J Motz; P L Kinney; Max Costa
Distribution of chromium within cells of the blood.
Toxicology and applied pharmacology 1991;108(1):157-66.
1991: Catherine B Klein; K Conway; X W Wang; R K Bhamra; X H Lin; M D Cohen; L Annab; J C Barrett; Max Costa
Senescence of nickel-transformed cells by an X chromosome: possible epigenetic control.
Science (New York, N.Y.) 1991;251(4995):796-9.
1991: C A Miller; Mitchell D Cohen; Max Costa
Complexing of actin and other nuclear proteins to DNA by cis-diamminedichloroplatinum(II) and chromium compounds.
Carcinogenesis 1991;12(2):269-76.
1991: X W Wang; Max Costa
Changes in protein phosphorylation in wild-type and nickel-resistant cells and their involvement in morphological elongation.
Biology of metals 1991;4(4):201-6.
1990: Max Costa
Analysis of DNA-protein complexes induced by chemical carcinogens.
Journal of cellular biochemistry 1990;44(3):127-35.
1990: Mitchell D Cohen; C A Miller; L S Xu; E T Snow; Max Costa
A blotting method for monitoring the formation of chemically induced DNA-protein complexes.
Analytical biochemistry 1990;186(1):1-7.
1990: C A Miller; Max Costa
Immunodetection of DNA-protein crosslinks by slot blotting.
Mutation research 1990;234(2):97-106.
1990: G N Cosma; C A Miller; Max Costa
The detection of DNA-protein complexes in vitro by an immunological assay.
Toxicology in vitro : an international journal published in association with BIBRA 1990;4(1):17-22.
1989: K Conway; Max Costa
Nonrandom chromosomal alterations in nickel-transformed Chinese hamster embryo cells.
Cancer research 1989;49(21):6032-8.
1989: R J Imbra; X W Wang; Max Costa
Characterization of a nickel resistant mouse cell line.
Biological trace element research 1989;21():97-103.
1989: K Conway; Max Costa
The involvement of heterochromatic damage in nickel-induced transformation.
Biological trace element research 1989;21():437-44.
1989: T P Coogan; D M Latta; R J Imbra; Max Costa
Effect of nickel(II) on DNA-protein interactions.
Biological trace element research 1989;21():13-21.
1989: Max Costa
Perspectives on the mechanism of nickel carcinogenesis gained from models of in vitro carcinogenesis.
Environmental health perspectives 1989;81():73-6.
1989: C A Miller; Max Costa
Immunological detection of DNA-protein complexes induced by chromate.
Carcinogenesis 1989;10(4):667-72.
1989: T P Coogan; D M Latta; E T Snow; Max Costa
Toxicity and carcinogenicity of nickel compounds.
Critical reviews in toxicology 1989;19(4):341-84.
1989: C A Miller; Max Costa
Analysis of proteins cross-linked to DNA after treatment of cells with formaldehyde, chromate, and cis-diamminedichloroplatinum(II).
Molecular toxicology 1989;2(1):11-26.
1988: X W Wang; R J Imbra; Max Costa
Characterization of mouse cell lines resistant to nickel(II) ions.
Cancer research 1988;48(23):6850-4.
1988: Judith T Zelikoff; J H Li; A Hartwig; X W Wang; Max Costa; Toby G Rossman
Genetic toxicology of lead compounds.
Carcinogenesis 1988;9(10):1727-32.
1988: N T Christie; P Sen; Max Costa
Chromosomal alterations in cell lines derived from mouse rhabdomyosarcomas induced by crystalline nickel sulfide.
Biology of metals 1988;1(1):43-50.
1988: C A Miller; Max Costa
Characterization of DNA-protein complexes induced in intact cells by the carcinogen chromate.
Molecular carcinogenesis 1988;1(2):125-33.