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Robert Costa

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Zebin Wang; Yu Zheng; Angela L Tyner; Srilata Bagchi; Janai R Carr; Yi-ju Chen; Robert H Costa; Jing Li; Hyun Jung Park; Pradip Raychaudhuri
FoxM1 in tumorigenicity of the neuroblastoma cells and renewal of the neural progenitors.
Hyun Jung Park; Galina Gusarova; Zebin Wang; Janai R Carr; Jing Li; Ki-Hyun Kim; Jin Qiu; Yoon-Dong Park; Peter R Williamson; Nissim Hay; Angela L Tyner; Lester F Lau; Robert H Costa; Pradip Raychaudhuri
Deregulation of FoxM1b leads to tumour metastasis.
Vladimir Petrovic; Robert H Costa; Lester F Lau; Pradip Raychaudhuri; Angela L Tyner
Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin.

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2011: Zebin Wang; Yu Zheng; Angela L Tyner; Srilata Bagchi; Janai R Carr; Yi-ju Chen; Robert H Costa; Jing Li; Hyun Jung Park; Pradip Raychaudhuri
FoxM1 in tumorigenicity of the neuroblastoma cells and renewal of the neural progenitors.
Cancer research 2011;71(12):4292-302.
2011: Hyun Jung Park; Galina Gusarova; Zebin Wang; Janai R Carr; Jing Li; Ki-Hyun Kim; Jin Qiu; Yoon-Dong Park; Peter R Williamson; Nissim Hay; Angela L Tyner; Lester F Lau; Robert H Costa; Pradip Raychaudhuri
Deregulation of FoxM1b leads to tumour metastasis.
EMBO molecular medicine 2011;3(1):21-34.
2010: Vladimir Petrovic; Robert H Costa; Lester F Lau; Pradip Raychaudhuri; Angela L Tyner
Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin.
Cancer biology & therapy 2010;9(12):1008-16.
2009: Hongjie Zhang; Elizabeth Tweedie Ables; Christine F Pope; M Kay Washington; Susan Hipkens; Anna L Means; Gunter Path; Jochen Seufert; Robert H Costa; Andrew B Leiter; Mark Magnuson; Maureen Gannon
Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation.
Mechanisms of development 2009;126(11-12):958-73.
2009: Yi-Ju Chen; Carmen Dominguez-Brauer; Zebin Wang; John M Asara; Robert H Costa; Angela L Tyner; Lester F Lau; Pradip Raychaudhuri
A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1.
The Journal of biological chemistry 2009;284(44):30695-707.
2009: Hyun Jung Park; Janai R Carr; Zebin Wang; Veronique Nogueira; Nissim Hay; Angela L Tyner; Lester F Lau; Robert H Costa; Pradip Raychaudhuri
FoxM1, a critical regulator of oxidative stress during oncogenesis.
The EMBO journal 2009;28(19):2908-18.
2008: Amanda Ackermann Misfeldt; Robert H Costa; Maureen Gannon
Beta-cell proliferation, but not neogenesis, following 60% partial pancreatectomy is impaired in the absence of FoxM1.
Diabetes 2008;57(11):3069-77.
2008: Hyun Jung Park; Robert H Costa; Lester F Lau; Angela L Tyner; Pradip Raychaudhuri
Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phase.
Molecular and cellular biology 2008;28(17):5162-71.
2008: I-Ching Wang; Yi-Ju Chen; Douglas E Hughes; Timothy Ackerson; Michael L Major; Vladimir V. Kalinichenko; Robert H Costa; Pradip Raychaudhuri; Angela L Tyner; Lester F Lau
FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness.
The Journal of biological chemistry 2008;283(30):20770-8.
2008: Hyun Jung Park; Z Wang; Robert H Costa; Angela L Tyner; Lester F Lau; Pradip Raychaudhuri
An N-terminal inhibitory domain modulates activity of FoxM1 during cell cycle.
Oncogene 2008;27(12):1696-704.
2008: Vladimir Petrovic; Robert H Costa; Lester F Lau; Pradip Raychaudhuri; Angela L Tyner
FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression.
The Journal of biological chemistry 2008;283(1):453-60.
2007: Yuichi Yoshida; I-Ching Wang; Helena M Yoder; Nicholas O Davidson; Robert H Costa
The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancer.
Gastroenterology 2007;132(4):1420-31.
2007: Sneha Ramakrishna; Il-Man Kim; Vladimir Petrovic; Dmitriy Malin; I-Ching Wang; Tanya V Kalin; Lucille Meliton; Youyang Zhao; Timothy Ackerson; Yimin Qin; Asrar B Malik; Robert H Costa; Vladimir V. Kalinichenko
Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(4):1000-13.
2007: Kumar U. Kotlo; Douglas E Hughes; Victoria L M Herrera; Nelson Ruiz-Opazo; Robert H Costa; R Brooks Robey; Robert S Danziger
Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant rat.
Hypertension 2007;49(3):467-72.
2007: Yongjun Tan; Pradip Raychaudhuri; Robert H Costa
Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes.
Molecular and cellular biology 2007;27(3):1007-16.
2007: Galina A Gusarova; I-Ching Wang; Michael L Major; Vladimir V. Kalinichenko; Timothy Ackerson; Vladimir Petrovic; Robert H Costa
A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatment.
The Journal of clinical investigation 2007;117(1):99-111.
2006: Senthil K Radhakrishnan; Uppoor G Bhat; Douglas E Hughes; I-Ching Wang; Robert H Costa; Andrei L Gartel
Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1.
Cancer research 2006;66(19):9731-5.
2006: Youyang Zhao; Xiao-Pei Gao; Yidan D Zhao; Muhammad Kamran Mirza; Randall S Frey; Vladimir V. Kalinichenko; I-Ching Wang; Robert H Costa; Asrar B Malik
Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury.
The Journal of clinical investigation 2006;116(9):2333-43.
2006: Hongjie Zhang; Amanda M Ackermann; Galina A Gusarova; David Lowe; Xue Feng; Usa G Kopsombut; Robert H Costa; Maureen Gannon
The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass.
Molecular endocrinology (Baltimore, Md.) 2006;20(8):1853-66.
2006: Yongjun Tan; Yuichi Yoshida; Douglas E Hughes; Robert H Costa
Increased expression of hepatocyte nuclear factor 6 stimulates hepatocyte proliferation during mouse liver regeneration.
Gastroenterology 2006;130(4):1283-300.
2006: Il-Man Kim; Timothy Ackerson; Sneha Ramakrishna; Maria Tretiakova; I-Ching Wang; Tanya V Kalin; Michael L Major; Galina A Gusarova; Helena M Yoder; Robert H Costa; Vladimir V. Kalinichenko
The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer.
Cancer research 2006;66(4):2153-61.
2006: Tanya V Kalin; I-Ching Wang; Timothy Ackerson; Michael L Major; Carol J Detrisac; Vladimir V. Kalinichenko; Aleksander V. Lyubimov; Robert H Costa
Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice.
Cancer research 2006;66(3):1712-20.
2006: Yuichi Yoshida; Douglas E Hughes; Francisco M Rausa; Il-Man Kim; Yongjun Tan; Gretchen J Darlington; Robert H Costa
C/EBPalpha and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells.
Hepatology (Baltimore, Md.) 2006;43(2):276-86.
2005: I-Ching Wang; Yi-Ju Chen; Douglas Hughes; Vladimir Petrovic; Michael L Major; Hyun Jung Park; Yongjun Tan; Timothy Ackerson; Robert H Costa
Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase.
Molecular and cellular biology 2005;25(24):10875-94.
2005: Il-Man Kim; Yan Zhou; Sneha Ramakrishna; Douglas E Hughes; Julian Solway; Robert H Costa; Vladimir V. Kalinichenko
Functional characterization of evolutionarily conserved DNA regions in forkhead box f1 gene locus.
The Journal of biological chemistry 2005;280(45):37908-16.
2005: Robert H Costa; Vladimir V. Kalinichenko; Vladimir V Kalinchenko; Yongjun Tan; I-Ching Wang
The CAR nuclear receptor and hepatocyte proliferation.
Hepatology (Baltimore, Md.) 2005;42(5):1004-8.
2005: Abhishek Datta; Jayita Sen; Jussara Hagen; Chandrashekhar K Korgaonkar; Michael Caffrey; Dawn E Quelle; Douglas E Hughes; Timothy Ackerson; Robert H Costa; Pradip Raychaudhuri
ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARF.
Molecular and cellular biology 2005;25(18):8024-36.
2005: Il-Man Kim; Sneha Ramakrishna; Galina A Gusarova; Helena M Yoder; Robert H Costa; Vladimir V. Kalinichenko
The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature.
The Journal of biological chemistry 2005;280(23):22278-86.
2005: Robert H Costa; Vladimir V. Kalinichenko; Michael L Major; Pradip Raychaudhuri
New and unexpected: forkhead meets ARF.
Current opinion in genetics & development 2005;15(1):42-8.
2004: Katherine Krupczak-Hollis; Xinhe Wang; Vladimir V. Kalinichenko; Galina A Gusarova; I-Ching Wang; Margaret B Dennewitz; Helena M Yoder; Hiroaki Kiyokawa; Klaus kaestner; Robert H Costa
The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis.
Developmental biology 2004;276(1):74-88.
2004: Francisco M Rausa; Douglas E Hughes; Robert H Costa
Stability of the hepatocyte nuclear factor 6 transcription factor requires acetylation by the CREB-binding protein coactivator.
The Journal of biological chemistry 2004;279(41):43070-6.
2004: Minhua Wang; Yongjun Tan; Robert H Costa; Ai-Xuan Holterman
In vivo regulation of murine CYP7A1 by HNF-6: a novel mechanism for diminished CYP7A1 expression in biliary obstruction.
Hepatology (Baltimore, Md.) 2004;40(3):600-8.
2004: Wanyun Sheng; Hong Yan; Francisco M Rausa; Robert H Costa; Xiubei Liao
Structure of the hepatocyte nuclear factor 6alpha and its interaction with DNA.
The Journal of biological chemistry 2004;279(32):33928-36.
2004: Vladimir V. Kalinichenko; Michael L Major; Xinhe Wang; Vladimir Petrovic; Joseph Kuechle; Helena M Yoder; Margaret B Dennewitz; Brian Shin; Abhishek Datta; Pradip Raychaudhuri; Robert H Costa
Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor.
Genes & development 2004;18(7):830-50.
2004: Michael L Major; Rita Lepe; Robert H Costa
Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivators.
Molecular and cellular biology 2004;24(7):2649-61.
2004: Vladimir V. Kalinichenko; Galina A Gusarova; Il-Man Kim; Brian Shin; Helena M Yoder; Jean Clark; Alexander M Sapozhnikov; Jeffrey A Whitsett; Robert H Costa
Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development.
American journal of physiology. Lung cellular and molecular physiology 2004;286(3):L521-30.
2003: Katherine Krupczak-Hollis; Xinhe Wang; Margaret B Dennewitz; Robert H Costa
Growth hormone stimulates proliferation of old-aged regenerating liver through forkhead box m1b.
Hepatology (Baltimore, Md.) 2003;38(6):1552-62.
2003: Robert H Costa; Vladimir V. Kalinichenko; Ai-Xuan Holterman; Xinhe Wang
Transcription factors in liver development, differentiation, and regeneration.
Hepatology (Baltimore, Md.) 2003;38(6):1331-47.
2003: Vladimir V. Kalinichenko; Galina A Gusarova; Yongjun Tan; I-Ching Wang; Michael L Major; Xinhe Wang; Helena M Yoder; Robert H Costa; Robert H Costal
Ubiquitous expression of the forkhead box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injury.
The Journal of biological chemistry 2003;278(39):37888-94.
2003: Olga A Kalinina; Sergey Kalinin; Evelyne W Polack; Igor Mikaelian; Suchismita Panda; Robert H Costa; Guy R Adami
Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesions.
Oncogene 2003;22(40):6266-76.
2003: Douglas E Hughes; Donna B Stolz; Songtao Yu; Yongjun Tan; Janardan K Reddy; simon simon watkins; Anna Mae Diehl; Robert H Costa
Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage.
Hepatology (Baltimore, Md.) 2003;37(6):1414-24.
2003: Vladimir V. Kalinichenko; Galina A Gusarova; Brian Shin; Robert H Costa
The forkhead box F1 transcription factor is expressed in brain and head mesenchyme during mouse embryonic development.
Gene expression patterns : GEP 2003;3(2):153-8.
2003: Xinhe Wang; Dibyendu Bhattacharyya; Margaret B Dennewitz; Vladimir V. Kalinichenko; Yan Zhou; Rita Lepe; Robert H Costa
Rapid hepatocyte nuclear translocation of the Forkhead Box M1B (FoxM1B) transcription factor caused a transient increase in size of regenerating transgenic hepatocytes.
Gene expression 2003;11(3-4):149-62.
2003: Francisco M Rausa; Yongjun Tan; Robert H Costa
Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding.
Molecular and cellular biology 2003;23(2):437-49.
2003: Vladimir V. Kalinichenko; Dibyendu Bhattacharyya; Yan Zhou; Galina A Gusarova; Wooram Kim; Brian Shin; Robert H Costa
Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury.
Hepatology (Baltimore, Md.) 2003;37(1):107-17.
2002: Xinhe Wang; Hiroaki Kiyokawa; Margaret B Dennewitz; Robert H Costa
The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16881-6.
2002: Krista E Banks; Aimee L Anderson; Hong Tang; Douglas E Hughes; Robert H Costa; Alan McLachlan
Hepatocyte nuclear factor 3beta inhibits hepatitis B virus replication in vivo.
Journal of virology 2002;76(24):12974-80.
2002: Xinhe Wang; Katherine Krupczak-Hollis; Yongjun Tan; Margaret B Dennewitz; Guy R Adami; Robert H Costa
Increased hepatic Forkhead Box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expression.
The Journal of biological chemistry 2002;277(46):44310-6.
2002: Ying Chen; Rajiv P Sharma; Robert H Costa; Erminio Costa; Dennis Grayson
On the epigenetic regulation of the human reelin promoter.
Nucleic acids research 2002;30(13):2930-9.
2002: Ai-Xuan Holterman; Yongjun Tan; Wooram Kim; Kyung W Yoo; Robert H Costa
Diminished hepatic expression of the HNF-6 transcription factor during bile duct obstruction.
Hepatology (Baltimore, Md.) 2002;35(6):1392-9.
2002: Vladimir V. Kalinichenko; Yan Zhou; Brian Shin; Donna B Stolz; simon simon watkins; Jeffrey A Whitsett; Robert H Costa
Wild-type levels of the mouse Forkhead Box f1 gene are essential for lung repair.
American journal of physiology. Lung cellular and molecular physiology 2002;282(6):L1253-65.
2002: Lorena Lim; Vladimir V. Kalinichenko; Jeffrey A Whitsett; Robert H Costa
Fusion of lung lobes and vessels in mouse embryos heterozygous for the forkhead box f1 targeted allele.
American journal of physiology. Lung cellular and molecular physiology 2002;282(5):L1012-22.
2002: Vladimir V. Kalinichenko; Yan Zhou; Dibyendu Bhattacharyya; Wooram Kim; Brian Shin; Kalyani Bambal; Robert H Costa
Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development.
The Journal of biological chemistry 2002;277(14):12369-74.
2002: Yongjun Tan; Guy R Adami; Robert H Costa
Maintaining HNF6 expression prevents AdHNF3beta-mediated decrease in hepatic levels of Glut-2 and glycogen.
Hepatology (Baltimore, Md.) 2002;35(4):790-8.
2002: Yongjun Tan; Douglas Hughes; Xinhe Wang; Robert H Costa
Adenovirus-mediated increase in HNF-3beta or HNF-3alpha shows differences in levels of liver glycogen and gene expression.
Hepatology (Baltimore, Md.) 2002;35(1):30-9.
2001: Songtao Yu; Wen-Qing Cao; Papreddy Kashireddy; Kirstin Meyer; Yuzhi Jia; Douglas E Hughes; Yongjun Tan; J Feng; Anjana V Yeldandi; M Sambasiva Rao; Robert H Costa; Frank J Gonzalez; Janardan K Reddy
Human peroxisome proliferator-activated receptor alpha (PPARalpha) supports the induction of peroxisome proliferation in PPARalpha-deficient mouse liver.
The Journal of biological chemistry 2001;276(45):42485-91.
2001: Alo Nag; Abhishek Datta; K Yoo; D Bhattacharyya; A Chakrabortty; X Wang; B L Slagle; Robert H Costa; Pradip Raychaudhuri
DDB2 induces nuclear accumulation of the hepatitis B virus X protein independently of binding to DDB1.
Journal of virology 2001;75(21):10383-92.
2001: Xinhe Wang; E Quail; NAI-JUNG HUNG; Yongjun Tan; Honggang Ye; Robert H Costa
Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11468-73.
2001: Vladimir V. Kalinichenko; Lorena Lim; Donna B Stolz; Brian Shin; Francisco M Rausa; J Clark; Jeffrey A Whitsett; simon simon watkins; Robert H Costa
Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor.
Developmental biology 2001;235(2):489-506.
2001: Xinhe Wang; NAI-JUNG HUNG; Robert H Costa
Earlier expression of the transcription factor HFH-11B diminishes induction of p21(CIP1/WAF1) levels and accelerates mouse hepatocyte entry into S-phase following carbon tetrachloride liver injury.
Hepatology (Baltimore, Md.) 2001;33(6):1404-14.
2001: Robert H Costa; Vladimir V. Kalinichenko; Lorena Lim
Transcription factors in mouse lung development and function.
American journal of physiology. Lung cellular and molecular physiology 2001;280(5):L823-38.
2001: Vladimir V. Kalinichenko; Lorena Lim; Brian Shin; Robert H Costa
Differential expression of forkhead box transcription factors following butylated hydroxytoluene lung injury.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L695-704.
2001: Yongjun Tan; Robert H Costa; Imre Kovesdi; R R Reichel
Adenovirus-mediated increase of HNF-3 levels stimulates expression of transthyretin and sonic hedgehog, which is associated with F9 cell differentiation toward the visceral endoderm lineage.
Gene expression 2001;9(6):237-48.
2001: H Zhou; Douglas E Hughes; M L Major; K Yoo; Christine Pesold; Robert H Costa
Atypical mouse cerebellar development is caused by ectopic expression of the forkhead box transcription factor HNF-3beta.
Gene expression 2001;9(4-5):217-36.
2000: Francisco M Rausa; Yongjun Tan; H Zhou; Kyung W Yoo; Donna B Stolz; simon simon watkins; Roberta Franks; Terry G Unterman; Robert H Costa
Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis.
Molecular and cellular biology 2000;20(21):8264-82.
2000: Maureen Gannon; MK Ray; K Van Zee; Francisco M Rausa; Robert H Costa; Christopher V E Wright
Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function.
Development (Cambridge, England) 2000;127(13):2883-95.
1999: Honggang Ye; Ai-Xuan Holterman; Kyung W Yoo; Roberta Franks; Robert H Costa
Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase.
Molecular and cellular biology 1999;19(12):8570-80.
1999: Francisco M Rausa; Luc Galarneau; L Bélanger; Robert H Costa
The nuclear receptor fetoprotein transcription factor is coexpressed with its target gene HNF-3beta in the developing murine liver, intestine and pancreas.
Mechanisms of development 1999;89(1-2):185-8.
1998: Francisco M Rausa; Honggang Ye; Lorena Lim; S A Duncan; Robert H Costa
In situ hybridization with 33P-labeled RNA probes for determination of cellular expression patterns of liver transcription factors in mouse embryos.
Methods (San Diego, Calif.) 1998;16(1):29-41.
1998: DE Clevidence; H Zhou; Lester F Lau; Robert H Costa
The -4 kilobase promoter region of the winged helix transcription factor HNF-3alpha gene elicits transgene expression in mouse embryonic hepatic and intestinal diverticula.
The International journal of developmental biology 1998;42(6):741-6.
1997: Vasudevan Lakshminarayanan; D W Beno; Robert H Costa; Kenneth A Roebuck
Differential regulation of interleukin-8 and intercellular adhesion molecule-1 by H2O2 and tumor necrosis factor-alpha in endothelial and epithelial cells.
The Journal of biological chemistry 1997;272(52):32910-8.
1997: Francisco M Rausa; U Samadani; Honggang Ye; Lorena Lim; C F Fletcher; Nancy A Jenkins; Neal G Copeland; Robert H Costa
The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas.
Developmental biology 1997;192(2):228-46.
1997: RS Peterson; Lorena Lim; Honggang Ye; H Zhou; DG Overdier; Robert H Costa
The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives.
Mechanisms of development 1997;69(1-2):53-69.
1997: Susan M Magdaleno; G Wang; Kathy J Jackson; MK Ray; Stephen E Welty; Robert H Costa; Francesco J DeMayo
Interferon-gamma regulation of Clara cell gene expression: in vivo and in vitro.
The American journal of physiology 1997;272(6 Pt 1):L1142-51.
1997: DG Overdier; Honggang Ye; RS Peterson; DE Clevidence; Robert H Costa
The winged helix transcriptional activator HFH-3 is expressed in the distal tubules of embryonic and adult mouse kidney.
The Journal of biological chemistry 1997;272(21):13725-30.
1997: L Lim; H Zhou; Robert H Costa
The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3094-9.
1997: Honggang Ye; T F Kelly; U Samadani; Lorena Lim; S Rubio; DG Overdier; Kenneth A Roebuck; Robert H Costa
Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues.
Molecular and cellular biology 1997;17(3):1626-41.
1997: RS Peterson; DE Clevidence; Honggang Ye; Robert H Costa
Hepatocyte nuclear factor-3 alpha promoter regulation involves recognition by cell-specific factors, thyroid transcription factor-1, and autoactivation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(1):69-82.
1996: U Samadani; Robert H Costa
The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression.
Molecular and cellular biology 1996;16(11):6273-84.
1996: U Samadani; X Qian; Robert H Costa
Identification of a transthyretin enhancer site that selectively binds the hepatocyte nuclear factor-3 beta isoform.
Gene expression 1996;6(1):23-33.
1995: U Samadani; Anna Porcella; Luca Pani; Peter F Johnson; John B E Burch; R Pine; Robert H Costa
Cytokine regulation of the liver transcription factor hepatocyte nuclear factor-3 beta is mediated by the C/EBP family and interferon regulatory factor 1.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(7):879-90.
1995: X Qian; Robert H Costa
Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targeting.
Nucleic acids research 1995;23(7):1184-91.
1995: X Qian; U Samadani; Anna Porcella; Robert H Costa
Decreased expression of hepatocyte nuclear factor 3 alpha during the acute-phase response influences transthyretin gene transcription.
Molecular and cellular biology 1995;15(3):1364-76.
1995: Karen B Avraham; C Fletcher; D G Overdier; D E Clevidence; E Lai; Robert H Costa; Nancy A Jenkins; Neal G Copeland
Murine chromosomal location of eight members of the hepatocyte nuclear factor 3/fork head winged helix family of transcription factors.
Genomics 1995;25(2):388-93.
1994: D E Clevidence; D G Overdier; R S Peterson; Anna Porcella; Honggang Ye; K E Paulson; Robert H Costa
Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter.
Developmental biology 1994;166(1):195-209.
1994: Terry G Unterman; A Fareeduddin; M A Harris; R G Goswami; Anna Porcella; Robert H Costa; Raul Lacson
Hepatocyte nuclear factor-3 (HNF-3) binds to the insulin response sequence in the IGF binding protein-1 (IGFBP-1) promoter and enhances promoter function.
Biochemical and biophysical research communications 1994;203(3):1835-41.
1994: A Jacob; S Budhiraja; X Qian; D Clevidence; Robert H Costa; R R Reichel
Retinoic acid-mediated activation of HNF-3 alpha during EC stem cell differentiation.
Nucleic acids research 1994;22(11):2126-33.
1994: D G Overdier; Anna Porcella; Robert H Costa
The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix.
Molecular and cellular biology 1994;14(4):2755-66.
1993: D E Clevidence; D G Overdier; W Tao; X Qian; Luca Pani; E Lai; Robert H Costa
Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(9):3948-52.
1992: Luca Pani; D G Overdier; Anna Porcella; X Qian; E Lai; Robert H Costa
Hepatocyte nuclear factor 3 beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein.
Molecular and cellular biology 1992;12(9):3723-32.
1992: Luca Pani; X B Quian; D Clevidence; Robert H Costa
The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3 beta involves a cell-specific factor and positive autoactivation.
Molecular and cellular biology 1992;12(2):552-62.
1991: Robert H Costa; Dennis Grayson
Site-directed mutagenesis of hepatocyte nuclear factor (HNF) binding sites in the mouse transthyretin (TTR) promoter reveal synergistic interactions with its enhancer region.
Nucleic acids research 1991;19(15):4139-45.
1990: Robert H Costa; Terry Van Dyke; C Yan; F Kuo; J E Darnell
Similarities in transthyretin gene expression and differences in transcription factors: liver and yolk sac compared to choroid plexus.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6589-93.
1990: Eseng Lai; Vincent Prezioso; E Smith; O Litvin; Robert H Costa; James E Darnell
HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.
Genes & development 1990;4(8):1427-36.
1990: C Yan; Robert H Costa; J E Darnell; J D Chen; Terry Van Dyke
Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice.
The EMBO journal 1990;9(3):869-78.
1989: Robert H Costa; Dennis Grayson; James E Darnell
Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.
Molecular and cellular biology 1989;9(4):1415-25.
1989: Dennis Grayson; Robert H Costa; J E Darnell
Regulation of hepatocyte-specific gene expression.
Annals of the New York Academy of Sciences 1989;557():243-55, discussion 255-6.
1988: Robert H Costa; Dennis Grayson; Kleanthis G Xanthopoulos; James E Darnell
A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(11):3840-4.
1988: Dennis Grayson; Robert H Costa; Kleanthis G Xanthopoulos; James E Darnell
A cell-specific enhancer of the mouse alpha 1-antitrypsin gene has multiple functional regions and corresponding protein-binding sites.
Molecular and cellular biology 1988;8(3):1055-66.
1988: Dennis Grayson; Robert H Costa; Kleanthis G Xanthopoulos; James E Darnell
One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes.
Science (New York, N.Y.) 1988;239(4841 Pt 1):786-8.
1988: Robert H Costa; Eseng Lai; Dennis Grayson; James E Darnell
The cell-specific enhancer of the mouse transthyretin (prealbumin) gene binds a common factor at one site and a liver-specific factor(s) at two other sites.
Molecular and cellular biology 1988;8(1):81-90.