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Frank Costantini

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Regina Willecke; Frank Costantini; Katja Grossmann; Julian Heuberger; Odyssé Michos; Kai Schmidt-Ott; Katharina Walentin; Walter Birchmeier
The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney.
Hanjun Kim; Minseong Kim; Rocky Kim; Taeyoon Kim; Wantae Kim; Jeong-sook Lee; Sehoon Won; Boksik Cha; Frank Costantini; Dae Youn Hwang; Daesoo Kim; Eek-Hoon Jho
Downregulation of Wnt/β-catenin signaling causes degeneration of hippocampal neurons in vivo.
Dayana Krawchuk; Shoshana J Weiner; You-Tzung Chen; Benson Lu; Frank Costantini; Richard R Behringer; Ed Laufer
Twist1 activity thresholds define multiple functions in limb development.

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2011: Regina Willecke; Frank Costantini; Katja Grossmann; Julian Heuberger; Odyssé Michos; Kai Schmidt-Ott; Katharina Walentin; Walter Birchmeier
The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney.
Developmental biology 2011;360(2):310-7.
2011: Hanjun Kim; Minseong Kim; Rocky Kim; Taeyoon Kim; Wantae Kim; Jeong-sook Lee; Sehoon Won; Boksik Cha; Frank Costantini; Dae Youn Hwang; Daesoo Kim; Eek-Hoon Jho
Downregulation of Wnt/β-catenin signaling causes degeneration of hippocampal neurons in vivo.
Neurobiology of aging 2011;32(12):2316.e1-15.
2010: Dayana Krawchuk; Shoshana J Weiner; You-Tzung Chen; Benson Lu; Frank Costantini; Richard R Behringer; Ed Laufer
Twist1 activity thresholds define multiple functions in limb development.
Developmental biology 2010;347(1):133-46.
2010: Frank Costantini
GDNF/Ret signaling and renal branching morphogenesis: From mesenchymal signals to epithelial cell behaviors.
Organogenesis 2010;6(4):252-62.
2010: Satu Kuure; Cristina Cebrian; Quentin Machingo; Benson Lu; Xuan Chi; Deborah Hyink; Vivette D'Agati; Christine Gurniak; Walter Witke; Frank Costantini
Actin depolymerizing factors cofilin1 and destrin are required for ureteric bud branching morphogenesis.
PLoS genetics 2010;6(10):e1001176.
2010: Satu Kuure; Xuan Chi; Benson Lu; Frank Costantini
The transcription factors Etv4 and Etv5 mediate formation of the ureteric bud tip domain during kidney development.
Development (Cambridge, England) 2010;137(12):1975-9.
2010: Frank Costantini; Raphael Kopan
Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development.
Developmental cell 2010;18(5):698-712.
2010: Odyssé Michos; Cristina Cebrian; Deborah Hyink; Uta Grieshammer; Linda Williams; Vivette D'Agati; Jonathan D Licht; Gail R Martin; Frank Costantini
Kidney development in the absence of Gdnf and Spry1 requires Fgf10.
PLoS genetics 2010;6(1):e1000809.
2010: Carolina Rosselot; Lee Spraggon; Ian Chia; Ekatherina Batourina; Paul Riccio; Benson Lu; Karen Niederreither; Pascal Dolle; Gregg Duester; Pierre Chambon; Frank Costantini; Thierry Gilbert; Andrei Molotkov; Cathy L Mendelsohn
Non-cell-autonomous retinoid signaling is crucial for renal development.
Development (Cambridge, England) 2010;137(2):283-92.
2009: Benson Lu; Cristina Cebrian; Xuan Chi; Satu Kuure; Richard Kuo; Carlton M Bates; Silvia Arber; John Hassell; Lesley MacNeil; Masato Hoshi; Sanjay Jain; Naoya Asai; Masahide Takahashi; Kai M Schmidt-Ott; Jonathan Barasch; Vivette D'Agati; Frank Costantini
Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis.
Nature genetics 2009;41(12):1295-302.
2009: Xuan Chi; Odyssé Michos; Reena Shakya; Paul Riccio; Hideki Enomoto; Jonathan D Licht; Naoya Asai; Masahide Takahashi; Nobutaka Ohgami; Masashi Kato; Cathy L Mendelsohn; Frank Costantini
Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis.
Developmental cell 2009;17(2):199-209.
2009: Ian V Chia; Min Jung Kim; Keiji Itoh; Sergei Y Sokol; Frank Costantini
Both the RGS domain and the six C-terminal amino acids of mouse Axin are required for normal embryogenesis.
Genetics 2009;181(4):1359-68.
2009: Xuan Chi; Anna-Katerina Hadjantonakis; Zaiqi Wu; Deborah Hyink; Frank Costantini
A transgenic mouse that reveals cell shape and arrangement during ureteric bud branching.
Genesis (New York, N.Y. : 2000) 2009;47(2):61-6.
2009: Eunjeong Seo; Hyunjoon Kim; Rokki Kim; Sangmoon Yun; Minseong Kim; Jin-Kwan Han; Frank Costantini; Eek-Hoon Jho
Multiple isoforms of beta-TrCP display differential activities in the regulation of Wnt signaling.
Cellular signalling 2009;21(1):43-51.
2008: Tomoya Kitamura; Naoya Asai; Atsushi Enomoto; Kengo Maeda; Takuya Kato; Maki Ishida; Ping Jiang; Takashi Watanabe; Jiro Usukura; Takahisa Kondo; Frank Costantini; Toyoaki Murohara; Masahide Takahashi
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.
Nature cell biology 2008;10(3):329-37.
2006: M Albert Basson; Judy Watson-Johnson; Reena Shakya; Simge Akbulut; Deborah P Hyink; Frank Costantini; Patricia D Wilson; Ivor Mason; Jonathan D Licht
Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1.
Developmental biology 2006;299(2):466-77.
2006: Naoya Asai; Toshifumi Fukuda; Zaiqi Wu; Atsushi Enomoto; Vassilis Pachnis; Masahide Takahashi; Frank Costantini
Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells.
Development (Cambridge, England) 2006;133(22):4507-16.
2006: Frank Costantini
Renal branching morphogenesis: concepts, questions, and recent advances.
Differentiation; research in biological diversity 2006;74(7):402-21.
2006: Frank Costantini; Reena Shakya
GDNF/Ret signaling and the development of the kidney.
BioEssays : news and reviews in molecular, cellular and developmental biology 2006;28(2):117-27.
2005: Adrianne Wong; Silvia Bogni; Pille Kotka; Esther de Graaff; Vivette D'Agati; Frank Costantini; Vassilis Pachnis
Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform.
Molecular and cellular biology 2005;25(21):9661-73.
2005: Kai M Schmidt-Ott; Jun Yang; Xia Chen; Howard Wang; Neal Paragas; Kiyoshi Mori; Jau-Yi Li; Benson Lu; Frank Costantini; Mario Schiffer; Erwin P Bottinger; Jonathan Barasch
Novel regulators of kidney development from the tips of the ureteric bud.
Journal of the American Society of Nephrology : JASN 2005;16(7):1993-2002.
2005: Reena Shakya; Eek-Hoon Jho; Pille Kotka; Zaiqi Wu; Nikolai Kholodilov; Robert Burke; Vivette D'Agati; Frank Costantini
The role of GDNF in patterning the excretory system.
Developmental biology 2005;283(1):70-84.
2005: Ian V Chia; Frank Costantini
Mouse axin and axin2/conductin proteins are functionally equivalent in vivo.
Molecular and cellular biology 2005;25(11):4371-6.
2005: M Albert Basson; Simge Akbulut; Judy Watson-Johnson; Ruth Simon; Thomas J. Carroll; Reena Shakya; Isabelle Gross; Gail R Martin; Thomas Lufkin; Andrew P McMahon; Patricia D Wilson; Frank Costantini; Ivor Mason; Jonathan D Licht
Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction.
Developmental cell 2005;8(2):229-39.
2005: Reena Shakya; Tomoko Watanabe; Frank Costantini
The role of GDNF/Ret signaling in ureteric bud cell fate and branching morphogenesis.
Developmental cell 2005;8(1):65-74.
2004: Jongkyu Choi; Sun Young Park; Frank Costantini; Eek-Hoon Jho; Choun-Ki Joo
Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin.
The Journal of biological chemistry 2004;279(47):49188-98.
2004: Tomoko Watanabe; Frank Costantini
Real-time analysis of ureteric bud branching morphogenesis in vitro.
Developmental biology 2004;271(1):98-108.
2003: Jungmook Lyu; Frank Costantini; Eek-Hoon Jho; Choun-Ki Joo
Ectopic expression of Axin blocks neuronal differentiation of embryonic carcinoma P19 cells.
The Journal of biological chemistry 2003;278(15):13487-95.
2002: Ekatherina Batourina; Christopher Choi; Neal Paragas; Natalie Bello; Terry W Hensle; Frank Costantini; Anita Schuchardt; Robert L Bacallao; Cathy L Mendelsohn
Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret.
Nature genetics 2002;32(1):109-15.
2002: Eek-Hoon Jho; Tong Zhang; Claire Domon; Choun-Ki Joo; Jean-Noel Freund; Frank Costantini
Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway.
Molecular and cellular biology 2002;22(4):1172-83.
2001: W Hsu; Reena Shakya; Frank Costantini
Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice.
The Journal of cell biology 2001;155(6):1055-64.
2001: Esther de Graaff; Shankar Srinivas; C Kilkenny; Vivette D'Agati; Baljinder S Mankoo; Frank Costantini; Vassilis Pachnis
Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis.
Genes & development 2001;15(18):2433-44.
2001: Ekatherina Batourina; S Gim; N Bello; chris hall; M Clagett-Dame; Shankar Srinivas; Frank Costantini; Cathy L Mendelsohn
Vitamin A controls epithelial/mesenchymal interactions through Ret expression.
Nature genetics 2001;27(1):74-8.
2000: A Primot; Blandine Baratte; M Gompel; A Borgne; S Liabeuf; J L Romette; Eek-Hoon Jho; Frank Costantini; Laurent Meijer
Purification of GSK-3 by affinity chromatography on immobilized axin.
Protein expression and purification 2000;20(3):394-404.
2000: MA Julius; B Schelbert; W Hsu; E Fitzpatrick; Eek-Hoon Jho; François Fagotto; Frank Costantini; Jan Kitajewski
Domains of axin and disheveled required for interaction and function in wnt signaling.
Biochemical and biophysical research communications 2000;276(3):1162-9.
2000: CONSTANCE SMITH HICKS; K C Sizer; James F Powers; Arthur S Tischler; Frank Costantini
C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B.
The EMBO journal 2000;19(4):612-22.
1999: Eek-Hoon Jho; Stavros Lomvardas; Frank Costantini
A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression.
Biochemical and biophysical research communications 1999;266(1):28-35.
1999: François Fagotto; Eek-Hoon Jho; L Zeng; T Kurth; Thomas O Joos; C Kaufmann; Frank Costantini
Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.
The Journal of cell biology 1999;145(4):741-56.
1999: Shankar Srinivas; Z Wu; Chiann-Mun Chen; Vivette D'Agati; Frank Costantini
Dominant effects of RET receptor misexpression and ligand-independent RET signaling on ureteric bud development.
Development (Cambridge, England) 1999;126(7):1375-86.
1999: W Hsu; L Zeng; Frank Costantini
Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain.
The Journal of biological chemistry 1999;274(6):3439-45.
1997: L Zeng; François Fagotto; T Zhang; W Hsu; thomas vasicek; W L Perry; J J Lee; Shirley M Tilghman; Barry M Gumbiner; Frank Costantini
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.
Cell 1997;90(1):181-92.
1996: Taube P Rothman; J Chen; M J Howard; Frank Costantini; A Schuchardt; Vassilis Pachnis; Michael D Gershon
Increased expression of laminin-1 and collagen (IV) subunits in the aganglionic bowel of ls/ls, but not c-ret -/- mice.
Developmental biology 1996;178(2):498-513.
1996: P Durbec; C V Marcos-Gutierrez; C Kilkenny; Marirena Grigoriou; K Wartiowaara; P Suvanto; D Smith; bruce ponder; Frank Costantini; Mart Saarma
GDNF signalling through the Ret receptor tyrosine kinase.
Nature 1996;381(6585):789-93.
1996: A Schuchardt; V D'Agati; Vassilis Pachnis; Frank Costantini
Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development.
Development (Cambridge, England) 1996;122(6):1919-29.
1996: C S Lin; S K Lim; V D'Agati; Frank Costantini
Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.
Genes & development 1996;10(2):154-64.
1996: P L Durbec; L B Larsson-Blomberg; A Schuchardt; Frank Costantini; Vassilis Pachnis
Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts.
Development (Cambridge, England) 1996;122(1):349-58.
1995: A Schuchardt; V D'Agati; L Larsson-Blomberg; Frank Costantini; Vassilis Pachnis
RET-deficient mice: an animal model for Hirschsprung's disease and renal agenesis.
Journal of internal medicine 1995;238(4):327-32.
1995: W L Perry; thomas vasicek; J J Lee; J M Rossi; L Zeng; T Zhang; Shirley M Tilghman; Frank Costantini
Phenotypic and molecular analysis of a transgenic insertional allele of the mouse Fused locus.
Genetics 1995;141(1):321-32.
1995: N P Anagnou; Carlos Perez-Stable; R Gelinas; Frank Costantini; K Liapaki; M Constantopoulou; T Kosteas; Nicholas K Moschonas; G Stamatoyannopoulos
Sequences located 3' to the breakpoint of the hereditary persistence of fetal hemoglobin-3 deletion exhibit enhancer activity and can modify the developmental expression of the human fetal A gamma-globin gene in transgenic mice.
The Journal of biological chemistry 1995;270(17):10256-63.
1995: A Schuchardt; Shankar Srinivas; Vassilis Pachnis; Frank Costantini
Isolation and characterization of a chicken homolog of the c-ret proto-oncogene.
Oncogene 1995;10(4):641-9.
1995: Larysa Pevny; C S Lin; V D'Agati; M C Simon; Stuart H Orkin; Frank Costantini
Development of hematopoietic cells lacking transcription factor GATA-1.
Development (Cambridge, England) 1995;121(1):163-72.
1994: A Schuchardt; V D'Agati; L Larsson-Blomberg; Frank Costantini; Vassilis Pachnis
Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret.
Nature 1994;367(6461):380-3.
1993: Vassilis Pachnis; B Mankoo; Frank Costantini
Expression of the c-ret proto-oncogene during mouse embryogenesis.
Development (Cambridge, England) 1993;119(4):1005-17.
1993: S S Cheng; Frank Costantini
Morula decompaction (mdn), a preimplantation recessive lethal defect in a transgenic mouse line.
Developmental biology 1993;156(1):265-77.
1993: A Himelstein; Maureen Ward; S Podda; E de la Flor Weiss; Frank Costantini; Arthur Bank
Long-term high-level expression of human beta-globin occurs following transplantation of transgenic marrow into irradiated mice.
American journal of hematology 1993;42(3):254-61.
1992: J J Lee; G Radice; C P Perkins; Frank Costantini
Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion.
Development (Cambridge, England) 1992;115(1):277-88.
1992: M C Simon; Larysa Pevny; M V Wiles; G Keller; Frank Costantini; Stuart H Orkin
Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells.
Nature genetics 1992;1(2):92-8.
1992: Elizabeth J Robertson; Frank L Conlon; K S Barth; Frank Costantini; J J Lee
Use of embryonic stem cells to study mutations affecting postimplantation development in the mouse.
Ciba Foundation symposium 1992;165():237-50; discussion 250-5.
1991: H J Son; K Shahan; M Rodriguez; E Derman; Frank Costantini
Identification of an enhancer required for the expression of a mouse major urinary protein gene in the submaxillary gland.
Molecular and cellular biology 1991;11(8):4244-52.
1991: Marie Trudel; V D'Agati; Frank Costantini
C-myc as an inducer of polycystic kidney disease in transgenic mice.
Kidney international 1991;39(4):665-71.
1991: G Radice; J J Lee; Frank Costantini
H beta 58, an insertional mutation affecting early postimplantation development of the mouse embryo.
Development (Cambridge, England) 1991;111(3):801-11.
1991: Larysa Pevny; M C Simon; E Robertson; W H Klein; S F Tsai; V D'Agati; Stuart H Orkin; Frank Costantini
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1.
Nature 1991;349(6306):257-60.
1991: H J Son; K Shahan; E Derman; Frank Costantini
Expression of a silent MUP gene in transgenic mice.
Biotechnology (Reading, Mass.) 1991;16():75-80.
1990: Ruibao Ren; Frank Costantini; E J Gorgacz; J J Lee; Vincent Racaniello
Transgenic mice expressing a human poliovirus receptor: a new model for poliomyelitis.
Cell 1990;63(2):353-62.
1990: Vassilis Pachnis; Larysa Pevny; Rodney Rothstein; Frank Costantini
Transfer of a yeast artificial chromosome carrying human DNA from Saccharomyces cerevisiae into mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):5109-13.
1990: Carlos Perez-Stable; Frank Costantini
Roles of fetal G gamma-globin promoter elements and the adult beta-globin 3' enhancer in the stage-specific expression of globin genes.
Molecular and cellular biology 1990;10(3):1116-25.
1990: Pierre Ferrier; B Krippl; T K Blackwell; A J Furley; H Suh; A Winoto; W D Cook; L Hood; Frank Costantini; F W Alt
Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.
The EMBO journal 1990;9(1):117-25.
1990: Marie Trudel; Marie-Claude Garel; N Saadane; Philippe Rouyer-Fessard; D Vidaud; Frank Costantini; Yves Beuzard
Towards a mouse model for sickle cell disease: HB SAD.
Nouvelle revue française d'hématologie 1990;32(6):407-8.
1989: J Magram; K Niederreither; Frank Costantini
Beta-globin enhancers target expression of a heterologous gene to erythroid tissues of transgenic mice.
Molecular and cellular biology 1989;9(10):4581-4.
1989: Y Shi; H J Son; K Shahan; M Rodriguez; Frank Costantini; E Derman
Silent genes in the mouse major urinary protein gene family.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4584-8.
1989: Carlos Perez-Stable; J Magram; K Niederreither; Frank Costantini
Analysis of human gamma and beta globin gene regulation using transgenic mice.
Progress in clinical and biological research 1989;316A():203-15.
1989: Frank Costantini; G Radice; J L Lee; Kiran Chada; W Perry; H J Son
Insertional mutations in transgenic mice.
Progress in nucleic acid research and molecular biology 1989;36():159-69.
1989: Pierre Ferrier; B Krippl; A J Furley; T K Blackwell; H Suh; Monica Mendelsohn; A Winoto; W D Cook; L Hood; Frank Costantini
Control of VDJ recombinase activity.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 1():191-202.
1987: Marie Trudel; J Magram; L Bruckner; Frank Costantini
Upstream G gamma-globin and downstream beta-globin sequences required for stage-specific expression in transgenic mice.
Molecular and cellular biology 1987;7(11):4024-9.
1987: Marie Trudel; Frank Costantini
A 3' enhancer contributes to the stage-specific expression of the human beta-globin gene.
Genes & development 1987;1(9):954-61.
1987: V da C Soares; R M Gubits; P Feigelson; Frank Costantini
Tissue-specific and hormonally regulated expression of a rat alpha 2u globulin gene in transgenic mice.
Molecular and cellular biology 1987;7(10):3749-58.
1987: Marie Trudel; J Magram; Kiran Chada; R Wilson; Frank Costantini
Expression of normal, mutant and hybrid human globin genes in transgenic mice.
Progress in clinical and biological research 1987;251():305-21.
1986: G Radice; Frank Costantini
Tissue-specific DNase I hypersensitive sites in a foreign globin gene in transgenic mice.
Nucleic acids research 1986;14(24):9765-80.
1986: Frank Costantini; Kiran Chada; J Magram
Correction of murine beta-thalassemia by gene transfer into the germ line.
Science (New York, N.Y.) 1986;233(4769):1192-4.
1986: Kiran Chada; J Magram; Frank Costantini
An embryonic pattern of expression of a human fetal globin gene in transgenic mice.
Nature 1986;319(6055):685-9.
1985: J Magram; Kiran Chada; Frank Costantini
Developmental regulation of a cloned adult beta-globin gene in transgenic mice.
Nature 1985;315(6017):338-40.
1985: Kiran Chada; J Magram; K Raphael; G Radice; Elizabeth Lacy; Frank Costantini
Specific expression of a foreign beta-globin gene in erythroid cells of transgenic mice.
Nature 1985;314(6009):377-80.
1985: Frank Costantini; G Radice; J Magram; G Stamatoyannopoulos; T Papayannopoulou; Kiran Chada
Developmental regulation of human globin genes in transgenic mice.
Cold Spring Harbor symposia on quantitative biology 1985;50():361-70.
1985: Kiran Chada; J Magram; Frank Costantini
Tissue- and stage-specific expression of a cloned adult beta globin gene in transgenic mice.
Progress in clinical and biological research 1985;191():305-19.