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Joseph Costello

Research Profile

Physiology

Chemicals & Drugs

Disorders

Anatomy

Tumor Cells, Cultured

Genes & Molecular Sequences

Genome, Human

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Publications

TOP 3
Raman P Nagarajan; Shaun D Fouse; Robert J A Bell; Joseph F Costello
Methods for cancer epigenome analysis.
Nicholas Butowski; Susan M Chang; Jennifer Clarke; Bruno M Costa; Joseph F Costello; Maria Hristova-Kazmierski; Emily Hsieh; Kathleen R Lamborn; Steven J Nicol; Angelina Nicole; Rupa Parvataneni; Russell Pieper; Mei-Yin Polley; Rui M Reis; Patricia K Sneed; Donald E Thornton; Scott Vandenberg; Michael D Prados
Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma.
Kwan-Yeung Wong; Joseph F Costello; Dong-Yan Jin; Raymond Liang; Chi-Chiu So; Chor-Sang Chim
Epigenetic silencing of MIR203 in multiple myeloma.

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All Publications

2013: Raman P Nagarajan; Shaun D Fouse; Robert J A Bell; Joseph F Costello
Methods for cancer epigenome analysis.
Advances in experimental medicine and biology 2013;754():313-38.
2011: Nicholas Butowski; Susan M Chang; Jennifer Clarke; Bruno M Costa; Joseph F Costello; Maria Hristova-Kazmierski; Emily Hsieh; Kathleen R Lamborn; Steven J Nicol; Angelina Nicole; Rupa Parvataneni; Russell Pieper; Mei-Yin Polley; Rui M Reis; Patricia K Sneed; Donald E Thornton; Scott Vandenberg; Michael D Prados
Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma.
Neuro-oncology 2011;13(12):1331-8.
2011: Kwan-Yeung Wong; Joseph F Costello; Dong-Yan Jin; Raymond Liang; Chi-Chiu So; Chor-Sang Chim
Epigenetic silencing of MIR203 in multiple myeloma.
British journal of haematology 2011;154(5):569-78.
2011: Yuki Ohi; Han Qin; Chibo Hong; Laure Blouin; Jose M Polo; Tingxia Guo; Zhongxia Qi; Sara L Downey; Philip D Manos; Derrick J Rossi; Jingwei Yu; Matthias Hebrok; Konrad Hochedlinger; Joseph F Costello; Jun S Song; Miguel Ramalho-Santos
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells.
Nature cell biology 2011;13(5):541-9.
2010: Alika K Maunakea; Raman P Nagarajan; Mikhail Bilenky; Tracy J Ballinger; Cletus D'Souza; Shaun D Fouse; Brett E Johnson; Chibo Hong; Cydney Nielsen; Yongjun Zhao; Gustavo Turecki; Allen Delaney; Richard Varhol; Nina Thiessen; Ksenya Shchors; Vivi M Heine; David H Rowitch; Xiaoyun Xing; Chris Fiore; Maximiliaan Schillebeeckx; Steven J M Jones; David Haussler; Marco A Marra; Martin Hirst; Ting Wang; Joseph F Costello
Conserved role of intragenic DNA methylation in regulating alternative promoters.
Nature 2010;466(7303):253-7.
2010: Ruihuan Chen; Merry C Nishimura; Stephanie M Bumbaca; Samir Kharbanda; William F Forrest; Ian Kasman; Joan M Greve; Robert Soriano; Laurie L Gilmour; Celina Sanchez Rivers; Zora Modrusan; Serban Nacu; Steve Guerrero; Kyle A Edgar; Jeffrey J Wallin; Katrin Lamszus; Manfred Westphal; Susanne Heim; C David James; Scott R Vandenberg; Joseph F Costello; Scott Moorefield; Cynthia J Cowdrey; Michael Prados; Heidi S Phillips
A hierarchy of self-renewing tumor-initiating cell types in glioblastoma.
Cancer cell 2010;17(4):362-75.
2010: Bruno M Costa; Justin S Smith; Ying Chen; Justin Chen; Heidi S Phillips; Kenneth Aldape; Giuseppe Zardo; Janice M Nigro; C David James; Jane Fridlyand; Rui M Reis; Joseph F Costello
Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma.
Cancer research 2010;70(2):453-62.
2009: Shaun D Fouse; Joseph F Costello
Epigenetics of neurological cancers.
Future oncology (London, England) 2009;5(10):1615-29.
2009: Peter Jun; Chibo Hong; Anita Lal; Judith M Wong; Michael W McDermott; Andrew W Bollen; Christoph Plass; William A Held; Dominic J Smiraglia; Joseph F Costello
Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.
Neuro-oncology 2009;11(4):414-22.
2009: Raman P Nagarajan; Joseph F Costello
Molecular epigenetics and genetics in neuro-oncology.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2009;6(3):436-46.
2009: Raman P Nagarajan; Joseph F Costello
Epigenetic mechanisms in glioblastoma multiforme.
Seminars in cancer biology 2009;19(3):188-97.
2009: Joseph F Costello; Chibo Hong; Christoph Plass; Dominic J Smiraglia
Restriction landmark genomic scanning: analysis of CpG islands in genomes by 2D gel electrophoresis.
Methods in molecular biology (Clifton, N.J.) 2009;507():131-48.
2008: Joo-Mi Yi; Hsing-Chen Tsai; Sabine C Glöckner; Steven Lin; Joyce E Ohm; Hari Easwaran; C David James; Joseph F Costello; Gregory J Riggins; Charles G Eberhart; John Laterra; Angelo L Vescovi; NITA AHUJA; James G Herman; Kornel E Schuebel; Stephen B Baylin
Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors.
Cancer research 2008;68(19):8094-103.
2008: Joseph F Costello
Stem cells: Tips for priming potency.
Nature 2008;454(7200):45-6.
2008: Joachim Silber; Daniel A Lim; Claudia Petritsch; Anders I Persson; Alika K Maunakea; Mamie Yu; Scott R Vandenberg; David Ginzinger; C David James; Joseph F Costello; Gabriele Bergers; William A Weiss; Arturo Alvarez-Buylla; J Graeme Hodgson
miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells.
BMC medicine 2008;6():14.
2008: Benjamin J Raphael; Stanislav Volik; Peng Yu; Chunxiao Wu; Guiqing Huang; Elena Linardopoulou; Barbara J Trask; Frederic Waldman; Joseph F Costello; Kenneth J Pienta; Gordon B Mills; Krystyna Bajsarowicz; Yasuko Kobayashi; Shivaranjani Sridharan; Pamela L Paris; Quanzhou Tao; Sarah J Aerni; Raymond P Brown; Ali Bashir; Joe Gray; Jan-Fang Cheng; Pieter de Jong; Mikhail Nefedov; Thomas Ried; Hesed Padilla-Nash; Colin C Collins
A sequence-based survey of the complex structural organization of tumor genomes.
Genome biology 2008;9(3):R59.
2007: Joseph F Smith; Saleh Mahmood; Fei Song; Arlene Morrow; Dominic J Smiraglia; Xueli Zhang; Ashwani Rajput; Michael J Higgins; Anton Krumm; Nicholas J Petrelli; Joseph F Costello; Hiroki Nagase; Christoph Plass; Werner Held
Identification of DNA methylation in 3' genomic regions that are associated with upregulation of gene expression in colorectal cancer.
Epigenetics : official journal of the DNA Methylation Society 2007;2(3):161-72.
2007: Chibo Hong; K Scott Moorefield; Peter Jun; Kenneth Aldape; Samir Kharbanda; Heidi S Phillips; Joseph F Costello
Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):10974-9.
2007: Romulo M Brena; Joseph F Costello
Genome-epigenome interactions in cancer.
Human molecular genetics 2007;16 Spec No 1():R96-105.
2007: Dominic J Smiraglia; Ramakrishnan Kazhiyur-Mannar; Christopher C Oakes; Yue-Zhong Wu; Ping Liang; Tahmina Ansari; Jian Su; Laura J Rush; Laura T Smith; Li Yu; Chunhui Liu; Zunyan Dai; shih-shih chen; Shu-Huei Wang; Joseph F Costello; Ilya P Ioshikhes; David W Dawson; Jason S Hong; Michael A Teitell; Angela Szafranek; Marta Camoriano; Fei Song; Rosemary Elliott; Werner Held; Jacquetta M Trasler; Christoph Plass; Rephael Wenger
Restriction landmark genomic scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations.
BMC genomics 2007;8():446.
2007: Lucia Helena Bonnemaison; Ivan Smirnov; Gilson Baia; Zora Modrusan; Justin S Smith; Peter Jun; Joseph F Costello; Michael W McDermott; Scott R Vandenberg; Anita Lal
Molecular signatures define two main classes of meningiomas.
Molecular cancer 2007;6():64.
2006: Romulo M Brena; Christoph Plass; Joseph F Costello
Mining methylation for early detection of common cancers.
PLoS medicine 2006;3(12):e479.
2006: Benoît Cadieux; Tsui-Ting Ching; Scott R Vandenberg; Joseph F Costello
Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation.
Cancer research 2006;66(17):8469-76.
2006: Paul A Reynolds; Mahvash Sigaroudinia; Giuseppe Zardo; Matthew B Wilson; Geoffrey M Benton; Caroline J Miller; Chibo Hong; Jane Fridlyand; Joseph F Costello; Thea D Tlsty
Tumor suppressor p16INK4A regulates polycomb-mediated DNA hypermethylation in human mammary epithelial cells.
The Journal of biological chemistry 2006;281(34):24790-802.
2006: Justin S Smith; Joseph F Costello
A broad band of silence.
Nature genetics 2006;38(5):504-6.
2006: F. Alex Feltus; Eva K Lee; Joseph F Costello; Christoph Plass; Paula M Vertino
DNA motifs associated with aberrant CpG island methylation.
Genomics 2006;87(5):572-9.
2006: Ying Chen; Amanda E. Toland; Jane McLennan; Jane Fridlyand; Beth Crawford; Joseph F Costello; John L Ziegler
Lack of germ-line promoter methylation in BRCA1-negative families with familial breast cancer.
Genetic testing 2006;10(4):281-4.
2005: Ileana C Cuevas; Alison L Slocum; Peter Jun; Joseph F Costello; Andrew W Bollen; Gregory J Riggins; Michael W McDermott; Anita Lal
Meningioma transcript profiles reveal deregulated Notch signaling pathway.
Cancer research 2005;65(12):5070-5.
2005: Tsui-Ting Ching; Alika K Maunakea; Peter Jun; Chibo Hong; Giuseppe Zardo; Daniel Pinkel; Donna G Albertson; Jane Fridlyand; Jian-Hua Mao; Ksenya Shchors; William A Weiss; Joseph F Costello
Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3.
Nature genetics 2005;37(6):645-51.
2005: Chibo Hong; Alika K Maunakea; Peter Jun; Andrew W Bollen; J Graeme Hodgson; David D Goldenberg; William A Weiss; Joseph F Costello
Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8.
Cancer research 2005;65(9):3617-23.
2005: Joseph F Costello
Comparative epigenomics of leukemia.
Nature genetics 2005;37(3):211-2.
2005: David Stokoe; Joseph F Costello
Phosphatase and tensin homologue growth suppression without phosphatase.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2677-8.
2003: Biao He; Liang You; Kazutsugu Uematsu; Keling Zang; Zhidong Xu; Amie Y Lee; Joseph F Costello; Frank McCormick; David M Jablons
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14133-8.
2003: Chibo Hong; Andrew W Bollen; Joseph F Costello
The contribution of genetic and epigenetic mechanisms to gene silencing in oligodendrogliomas.
Cancer research 2003;63(22):7600-5.
2003: F. Alex Feltus; Eva K Lee; Joseph F Costello; C Plass; Paula M Vertino
Predicting aberrant CpG island methylation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12253-8.
2003: Joseph F Costello
DNA methylation in brain development and gliomagenesis.
Frontiers in bioscience : a journal and virtual library 2003;8():s175-84.
2002: Giuseppe Zardo; Maarit Tiirikainen; Chibo Hong; Anjan Misra; Burt Feuerstein; Stanislav Volik; Colin C Collins; Kathleen R Lamborn; Andrew Bollen; Daniel Pinkel; Donna G Albertson; Joseph F Costello
Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors.
Nature genetics 2002;32(3):453-8.
2002: Joseph F Costello; Dominic J Smiraglia; Christoph Plass
Restriction landmark genome scanning.
Methods (San Diego, Calif.) 2002;27(2):144-9.
2002: Joseph F Costello; Paula M Vertino
Methylation matters: a new spin on maspin.
Nature genetics 2002;31(2):123-4.
2002: Joseph F Costello; Christoph Plass; Webster K Cavenee
Restriction landmark genome scanning.
Methods in molecular biology (Clifton, N.J.) 2002;200():53-70.
2001: Dominic J Smiraglia; Laura J Rush; Michael C Frühwald; Zunyan Dai; Werner Held; Joseph F Costello; James C Lang; Charis Eng; B Li; Fred A Wright; Michael A Caligiuri; Christoph Plass
Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies.
Human molecular genetics 2001;10(13):1413-9.
2001: Laura J Rush; Zunyan Dai; Dominic J Smiraglia; X Gao; Fred A Wright; Michael C Frühwald; Joseph F Costello; Werner Held; Li Yu; Ralf Krahe; Jonathan E Kolitz; Clara D Bloomfield; Michael A Caligiuri; Christoph Plass
Novel methylation targets in de novo acute myeloid leukemia with prevalence of chromosome 11 loci.
Blood 2001;97(10):3226-33.
2001: Joseph F Costello; C Plass
Methylation matters.
Journal of medical genetics 2001;38(5):285-303.
2000: Michael C Frühwald; M Sue O'Dorisio; Laura J Rush; J L Reiter; Dominic J Smiraglia; Gail D Wenger; Joseph F Costello; Peter White; Ralf Krahe; G M Brodeur; Christoph Plass
Gene amplification in PNETs/medulloblastomas: mapping of a novel amplified gene within the MYCN amplicon.
Journal of medical genetics 2000;37(7):501-9.
2000: Joseph F Costello; Michael C Frühwald; Dominic J Smiraglia; Laura J Rush; Gavin P. Robertson; X Gao; Fred A Wright; J D Feramisco; P Peltomäki; James C Lang; D E Schuller; Li Yu; C D Bloomfield; Michael A Caligiuri; A Yates; R Nishikawa; HJ Su Huang; N J Petrelli; X Zhang; M Sue O'Dorisio; W A Held; Webster K Cavenee; Christoph Plass
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.
Nature genetics 2000;24(2):132-8.
2000: Joseph F Costello; C Plass; W K Cavenee
Aberrant methylation of genes in low-grade astrocytomas.
Brain tumor pathology 2000;17(2):49-56.
1999: Dominic J Smiraglia; Michael C Frühwald; Joseph F Costello; S P McCormick; Zunyan Dai; Päivi Peltomäki; M Sue O'Dorisio; Webster K Cavenee; Christoph Plass
A new tool for the rapid cloning of amplified and hypermethylated human DNA sequences from restriction landmark genome scanning gels.
Genomics 1999;58(3):254-62.
1999: Kurtis E Bachman; James G Herman; P G Corn; A Merlo; Joseph F Costello; W K Cavenee; Stephen B Baylin; Jeremy R Graff
Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers.
Cancer research 1999;59(4):798-802.
1997: George S Watts; R O Pieper; Joseph F Costello; Yei-Mei Peng; W S Dalton; Bernard W Futscher
Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene.
Molecular and cellular biology 1997;17(9):5612-9.
1997: Christoph Plass; Dieter Weichenhan; Joe Catanese; Joseph F Costello; F Yu; L Yu; Dominic J Smiraglia; W K Cavenee; M A Caligiuri; P deJong; Werner Held
An arrayed human not I-EcoRV boundary library as a tool for RLGS spot analysis.
DNA research : an international journal for rapid publication of reports on genes and genomes 1997;4(3):253-5.
1997: Joseph F Costello; Christoph Plass; W Arap; Verne M Chapman; Werner Held; M S Berger; HJ Su Huang; Webster K Cavenee
Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA.
Cancer research 1997;57(7):1250-4.
1996: R O Pieper; S Patel; S A Ting; Bernard W Futscher; Joseph F Costello
Methylation of CpG island transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene.
The Journal of biological chemistry 1996;271(23):13916-24.
1996: Joseph F Costello; M S Berger; H S Huang; Webster K Cavenee
Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.
Cancer research 1996;56(10):2405-10.
1995: C L Nutt; Joseph F Costello; Linda L Bambrick; D B Yarosh; L J Swinnen; Ann F Chambers; J Gregory Cairncross
O6-methylguanine-DNA methyltransferase in tumors and cells of the oligodendrocyte lineage.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 1995;22(2):111-5.
1994: Joseph F Costello; Bernard W Futscher; Roger Kroes; R O Pieper
Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines.
Molecular and cellular biology 1994;14(10):6515-21.
1994: Joseph F Costello; Bernard W Futscher; K Tano; D M Graunke; R O Pieper
Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells.
The Journal of biological chemistry 1994;269(25):17228-37.
1991: R O Pieper; Joseph F Costello; Roger Kroes; Bernard W Futscher; U Marathi; L C Erickson
Direct correlation between methylation status and expression of the human O-6-methylguanine DNA methyltransferase gene.
Cancer communications 1991;3(8):241-53.
1991: Joseph F Costello; M R Brown; Thackery S Gray
Bombesin immunoreactive neurons in the hypothalamic paraventricular nucleus innervate the dorsal vagal complex in the rat.
Brain research 1991;542(1):77-82.