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Ian Cotgreave

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Björn Glinghammar; Ingalill Rafter; Anna-Karin Lindström; Jesper J Hedberg; Håkan B Andersson; Per Lindblom; Anna-Lena Berg; Ian A Cotgreave
Detection of the mitochondrial and catalytically active alanine aminotransferase in human tissues and plasma.
Petra Thulin; Ingalill Rafter; Kenneth Stockling; Celine Tomkiewicz; Ensio Norjavaara; Martine Aggerbeck; Heike Hellmold; Ewa Ehrenborg; Ulf Andersson; Ian A Cotgreave; B Glinghammar
PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes.
Per Lindblom; Ingalill Rafter; Clive Copley; Ulf Andersson; Jesper J Hedberg; Anna-Lena Berg; Anders Samuelsson; Heike Hellmold; Ian A Cotgreave; Björn Glinghammar
Isoforms of alanine aminotransferases in human tissues and serum--differential tissue expression using novel antibodies.

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All Publications

2009: Björn Glinghammar; Ingalill Rafter; Anna-Karin Lindström; Jesper J Hedberg; Håkan B Andersson; Per Lindblom; Anna-Lena Berg; Ian A Cotgreave
Detection of the mitochondrial and catalytically active alanine aminotransferase in human tissues and plasma.
International journal of molecular medicine 2009;23(5):621-31.
2008: Petra Thulin; Ingalill Rafter; Kenneth Stockling; Celine Tomkiewicz; Ensio Norjavaara; Martine Aggerbeck; Heike Hellmold; Ewa Ehrenborg; Ulf Andersson; Ian A Cotgreave; B Glinghammar
PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes.
Toxicology and applied pharmacology 2008;231(1):1-9.
2007: Per Lindblom; Ingalill Rafter; Clive Copley; Ulf Andersson; Jesper J Hedberg; Anna-Lena Berg; Anders Samuelsson; Heike Hellmold; Ian A Cotgreave; Björn Glinghammar
Isoforms of alanine aminotransferases in human tissues and serum--differential tissue expression using novel antibodies.
Archives of biochemistry and biophysics 2007;466(1):66-77.
2007: Monica Ek; Therese Söderdahl; Barbara Küppers-Munther; Josefina Edsbagge; Tommy B Andersson; Petter Björquist; Ian A Cotgreave; Bengt Jernström; Magnus Ingelman-Sundberg; Inger Johansson
Expression of drug metabolizing enzymes in hepatocyte-like cells derived from human embryonic stem cells.
Biochemical pharmacology 2007;74(3):496-503.
2007: Therese Söderdahl; Barbara Küppers-Munther; Nico Heins; Josefina Edsbagge; Petter Björquist; Ian A Cotgreave; Bengt Jernström
Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells.
Toxicology in vitro : an international journal published in association with BIBRA 2007;21(5):929-37.
2005: Ylva Hamnell-Pamment; Christina Lind; Carina Palmberg; Tomas Bergman; Ian A Cotgreave
Determination of site-specificity of S-glutathionylated cellular proteins.
Biochemical and biophysical research communications 2005;332(2):362-9.
2005: Erika Witasp; Ann-Catrin Gustafsson; Ian A Cotgreave; P Monica Lind; Bengt Fadeel
Vitamin D fails to prevent serum starvation- or staurosporine-induced apoptosis in human and rat osteosarcoma-derived cell lines.
Biochemical and biophysical research communications 2005;330(3):891-7.
2005: Tim Hofer; Carine Badouard; Edyta Bajak; Jean-Luc Ravanat; Ase Mattsson; Ian A Cotgreave
Hydrogen peroxide causes greater oxidation in cellular RNA than in DNA.
Biological chemistry 2005;386(4):333-7.
2005: Ian A Cotgreave
Biological stress responses to radio frequency electromagnetic radiation: are mobile phones really so (heat) shocking?
Archives of biochemistry and biophysics 2005;435(1):227-40.
2004: Claudia A Staab; Martin Vondracek; Hipolito Custodio; Katarina Johansson; Jan-Anders Nilsson; Peter Morgan; Jan-Olov Höög; Ian A Cotgreave; Roland C Grafström
Modelling of normal and premalignant oral tissue by using the immortalised cell line, SVpgC2a: a review of the value of the model.
Alternatives to laboratory animals : ATLA 2004;32(4):401-5.
2004: Tiziana Dandrea; Heike Hellmold; Carina Jonsson; Boris Zhivotovsky; Tim Hofer; Lars Wärngård; Ian A Cotgreave
The transcriptosomal response of human A549 lung cells to a hydrogen peroxide-generating system: relationship to DNA damage, cell cycle arrest, and caspase activation.
Free radical biology & medicine 2004;36(7):881-96.
2004: Michael McNaughton; Lars Engman; Anne Birmingham; Garth Powis; Ian A Cotgreave
Cyclodextrin-derived diorganyl tellurides as glutathione peroxidase mimics and inhibitors of thioredoxin reductase and cancer cell growth.
Journal of medicinal chemistry 2004;47(1):233-9.
2003: Michail Tonkonogi; Jan Henriksson; Ian A Cotgreave
Human skeletal muscle interstitial glutathione levels are elevated in comparison to adipose tissue and blood plasma.
Archives of biochemistry and biophysics 2003;413(1):147-9.
2003: Ian A Cotgreave
Analytical developments in the assay of intra- and extracellular GSH homeostasis: specific protein S-glutathionylation, cellular GSH and mixed disulphide compartmentalisation and interstitial GSH redox balance.
BioFactors (Oxford, England) 2003;17(1-4):269-77.
2003: Therese Söderdahl; Mari Enoksson; Mathias Lundberg; Arne Holmgren; Ole Petter Ottersen; Sten Orrenius; George Bolcsfoldi; Ian A Cotgreave
Visualization of the compartmentalization of glutathione and protein-glutathione mixed disulfides in cultured cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):124-6.
2002: Tiziana Dandrea; Edyta Bajak; Lars Wärngård; Ian A Cotgreave
Protein S-glutathionylation correlates to selective stress gene expression and cytoprotection.
Archives of biochemistry and biophysics 2002;406(2):241-52.
2002: Christina Lind; Robert Gerdes; Ylva Hamnell; Ina Schuppe-Koistinen; Helena Brockenhuus von Löwenhielm; Arne Holmgren; Ian A Cotgreave
Identification of S-glutathionylated cellular proteins during oxidative stress and constitutive metabolism by affinity purification and proteomic analysis.
Archives of biochemistry and biophysics 2002;406(2):229-40.
2002: MB Svensson; Björn Ekblom; Ian A Cotgreave; B Norman; Berit Sjöberg; Orjan Ekblom; B Sjödin; A Sjödin
Adaptive stress response of glutathione and uric acid metabolism in man following controlled exercise and diet.
Acta physiologica Scandinavica 2002;176(1):43-56.
2002: Vladimir Gogvadze; Helene Stridh; Sten Orrenius; Ian A Cotgreave
Tributyltin causes cytochrome C release from isolated mitochondria by two discrete mechanisms.
Biochemical and biophysical research communications 2002;292(4):904-8.
2002: Ian A Cotgreave; Lina Goldschmidt; Michail Tonkonogi; Michael Svensson
Differentiation-specific alterations to glutathione synthesis in and hormonally stimulated release from human skeletal muscle cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(3):435-7.
2002: Ian A Cotgreave; Robert Gerdes; Ina Schuppe-Koistinen; Christina Lind
S-glutathionylation of glyceraldehyde-3-phosphate dehydrogenase: role of thiol oxidation and catalysis by glutaredoxin.
Methods in enzymology 2002;348():175-82.
2001: Helene Stridh; Ian A Cotgreave; M Müller; Sten Orrenius; D Gigliotti
Organotin-induced caspase activation and apoptosis in human peripheral blood lymphocytes.
Chemical research in toxicology 2001;14(7):791-8.
2001: Jonas Malmström; M Jonsson; Ian A Cotgreave; Leif Hammarström; M Sjödin; Lars Engman
The antioxidant profile of 2,3-dihydrobenzo[b]furan-5-ol and its 1-thio, 1-seleno, and 1-telluro analogues.
Journal of the American Chemical Society 2001;123(15):3434-40.
2001: Afshin Samali; J D Robertson; E Peterson; Florence Manero; L van Zeijl; C Paul; Ian A Cotgreave; André-Patrick Arrigo; Sten Orrenius
Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli.
Cell stress & chaperones 2001;6(1):49-58.
1999: Helene Stridh; D Gigliotti; Sten Orrenius; Ian A Cotgreave
The role of calcium in pre- and postmitochondrial events in tributyltin-induced T-cell apoptosis.
Biochemical and biophysical research communications 1999;266(2):460-5.
1999: KL Dahlin; K Bohlin; J Strindlund; Ake Ryrfeldt; Ian A Cotgreave
Amitriptyline-induced loss of tight junction integrity in a human endothelial--smooth muscle cell bi-layer model.
Toxicology 1999;136(1):1-13.
1999: Marjan Boerma; L Forsberg; L Van Zeijl; Ralf Morgenstern; Ulf de Faire; Carola Lemne; D Erlinge; Thomas Thulin; Y Hong; Ian A Cotgreave
A genetic polymorphism in connexin 37 as a prognostic marker for atherosclerotic plaque development.
Journal of internal medicine 1999;246(2):211-8.
1999: K Bohlin; Ian A Cotgreave
Pro-inflammatory cytokines increase the permeability of paracetamol across a human endothelial-smooth muscle cell bilayer model.
Scandinavian journal of clinical and laboratory investigation 1999;59(4):259-66.
1999: D H Burgess; M Svensson; Tiziana Dandrea; K Grönlund; F Hammarquist; Sten Orrenius; Ian A Cotgreave
Human skeletal muscle cytosols are refractory to cytochrome c-dependent activation of type-II caspases and lack APAF-1.
Cell death and differentiation 1999;6(3):256-61.
1999: P Garberg; Lars Engman; Vladimir Tolmachev; H Lundqvist; Robert Gerdes; Ian A Cotgreave
Binding of tellurium to hepatocellular selenoproteins during incubation with inorganic tellurite: consequences for the activity of selenium-dependent glutathione peroxidase.
The international journal of biochemistry & cell biology 1999;31(2):291-301.
1998: Ian A Cotgreave
Session 3: stress response.
Toxicology in vitro : an international journal published in association with BIBRA 1998;12(5):569-73.
1998: I Voskoboinik; K Söderholm; Ian A Cotgreave
Ascorbate and glutathione homeostasis in vascular smooth muscle cells: cooperation with endothelial cells.
The American journal of physiology 1998;275(4 Pt 1):C1031-9.
1998: Christina Lind; Robert Gerdes; Ina Schuppe-Koistinen; Ian A Cotgreave
Studies on the mechanism of oxidative modification of human glyceraldehyde-3-phosphate dehydrogenase by glutathione: catalysis by glutaredoxin.
Biochemical and biophysical research communications 1998;247(2):481-6.
1998: K Briviba; R Tamler; Lars-Oliver Klotz; Lars Engman; Ian A Cotgreave; Helmut Sies
Protection by organotellurium compounds against peroxynitrite-mediated oxidation and nitration reactions.
Biochemical pharmacology 1998;55(6):817-23.
1998: Ian A Cotgreave; Robert Gerdes
Recent trends in glutathione biochemistry--glutathione-protein interactions: a molecular link between oxidative stress and cell proliferation?
Biochemical and biophysical research communications 1998;242(1):1-9.
1997: Lars Engman; Ian A Cotgreave; M Angulo; C W Taylor; Gillian Paine-Murrieta; Garth Powis
Diaryl chalcogenides as selective inhibitors of thioredoxin reductase and potential antitumor agents.
Anticancer research 1997;17(6D):4599-605.
1997: Tiziana Dandrea; B Tu; A Blomberg; T Sandström; M Sköld; A Eklund; Ian A Cotgreave
Differential inhibition of inflammatory cytokine release from cultured alveolar macrophages from smokers and non-smokers by NO2.
Human & experimental toxicology 1997;16(10):577-88.
1997: Jing Hu; Ian A Cotgreave
Differential regulation of gap junctions by proinflammatory mediators in vitro.
The Journal of clinical investigation 1997;99(10):2312-6.
1997: Garth Powis; JR Gasdaska; PY Gasdaska; Margareta I Berggren; D Lynn Kirkpatrick; Lars Engman; Ian A Cotgreave; M Angulo; Amanda Baker
Selenium and the thioredoxin redox system: effects on cell growth and death.
Oncology research 1997;9(6-7):303-12.
1995: B Tu; Alf Wallin; P Moldéus; Ian A Cotgreave
Direct exposure to nitrogen dioxide fails to induce the expression of some inflammatory cytokines in an IC-21 murine macrophage cell model.
Toxicology 1995;104(1-3):159-64.
1995: Jing Hu; H Speisky; Ian A Cotgreave
The inhibitory effects of boldine, glaucine, and probucol on TPA-induced down regulation of gap junction function. Relationships to intracellular peroxides, protein kinase C translocation, and connexin 43 phosphorylation.
Biochemical pharmacology 1995;50(10):1635-43.
1995: A Ek; K Ström; Ian A Cotgreave
The uptake of ascorbic acid into human umbilical vein endothelial cells and its effect on oxidant insult.
Biochemical pharmacology 1995;50(9):1339-46.
1995: Jing Hu; Lars Engman; Ian A Cotgreave
Redox-active chalcogen-containing glutathione peroxidase mimetics and antioxidants inhibit tumour promoter-induced downregulation of gap junctional intercellular communication between WB-F344 liver epithelial cells.
Carcinogenesis 1995;16(8):1815-24.
1995: Jing Hu; Ian A Cotgreave
Glutathione depletion potentiates 12-O-tetradecanoyl phorbol-13-acetate(TPA)-induced inhibition of gap junctional intercellular communication in WB-F344 rat liver epithelial cells: relationship to intracellular oxidative stress.
Chemico-biological interactions 1995;95(3):291-307.
1995: B Tu; Alf Wallin; P Moldéus; Ian A Cotgreave
The cytoprotective roles of ascorbate and glutathione against nitrogen dioxide toxicity in human endothelial cells.
Toxicology 1995;98(1-3):125-36.
1995: G Bannenberg; J Xue; Lars Engman; Ian A Cotgreave; P Moldéus; Ake Ryrfeldt
Characterization of bronchodilator effects and fate of S-nitrosothiols in the isolated perfused and ventilated guinea pig lung.
The Journal of pharmacology and experimental therapeutics 1995;272(3):1238-45.
1995: B Tu; Alf Wallin; P Moldéus; Ian A Cotgreave
Cytotoxicity of NO2 gas to cultured human and murine cells in an inverted monolayer exposure system.
Toxicology 1995;96(1):7-18.
1994: I Schuppe-Koistinen; Robert Gerdes; P Moldéus; Ian A Cotgreave
Studies on the reversibility of protein S-thiolation in human endothelial cells.
Archives of biochemistry and biophysics 1994;315(2):226-34.
1994: P Y Gasdaska; J E Oblong; Ian A Cotgreave; Garth Powis
The predicted amino acid sequence of human thioredoxin is identical to that of the autocrine growth factor human adult T-cell derived factor (ADF): thioredoxin mRNA is elevated in some human tumors.
Biochimica et biophysica acta 1994;1218(3):292-6.
1994: B Tu; Alf Wallin; P Moldéus; Ian A Cotgreave
Individual, culture-specific alterations in the human endothelial glutathione system: relationships to oxidant toxicity.
Pharmacology & toxicology 1994;75(2):82-90.
1994: Ian A Cotgreave; I Schuppe-Koistinen
A role for gamma-glutamyl transpeptidase in the transport of cystine into human endothelial cells: relationship to intracellular glutathione.
Biochimica et biophysica acta 1994;1222(3):375-82.
1994: C M Andersson; Ralph Brattsand; Anders Hallberg; Lars Engman; J Persson; P Moldéus; Ian A Cotgreave
Diaryl tellurides as inhibitors of lipid peroxidation in biological and chemical systems.
Free radical research 1994;20(6):401-10.
1994: I Schuppe-Koistinen; P Moldéus; T Bergman; Ian A Cotgreave
S-thiolation of human endothelial cell glyceraldehyde-3-phosphate dehydrogenase after hydrogen peroxide treatment.
European journal of biochemistry / FEBS 1994;221(3):1033-7.
1994: C M Andersson; Anders Hallberg; M Linden; Ralph Brattsand; P Moldéus; Ian A Cotgreave
Antioxidant activity of some diarylselenides in biological systems.
Free radical biology & medicine 1994;16(1):17-28.
1992: Y Liu; Ian A Cotgreave; Luigi Atzori; Roland C Grafström
The mechanism of Hg2+ toxicity in cultured human oral fibroblasts: the involvement of cellular thiols.
Chemico-biological interactions 1992;85(1):69-78.
1992: I Schuppe; P Moldéus; Ian A Cotgreave
Protein-specific S-thiolation in human endothelial cells during oxidative stress.
Biochemical pharmacology 1992;44(9):1757-64.
1992: Ralf Morgenstern; Ian A Cotgreave; Lars Engman
Determination of the relative contributions of the diselenide and selenol forms of ebselen in the mechanism of its glutathione peroxidase-like activity.
Chemico-biological interactions 1992;84(1):77-84.
1992: Ian A Cotgreave; Ralf Morgenstern; Lars Engman; J Ahokas
Characterisation and quantitation of a selenol intermediate in the reaction of ebselen with thiols.
Chemico-biological interactions 1992;84(1):69-76.
1992: Y Nakagawa; P Moldéus; Ian A Cotgreave
The S-thiolation of hepatocellular protein thiols during diquat metabolism.
Biochemical pharmacology 1992;43(12):2519-25.
1992: M Weis; Ralf Morgenstern; Ian A Cotgreave; S D Nelson; P Moldéus
N-acetyl-p-benzoquinone imine-induced protein thiol modification in isolated rat hepatocytes.
Biochemical pharmacology 1992;43(7):1493-505.
1992: Ian A Cotgreave; P Moldéus; Ralph Brattsand; Anders Hallberg; C M Andersson; Lars Engman
Alpha-(phenylselenenyl)acetophenone derivatives with glutathione peroxidase-like activity. A comparison with ebselen.
Biochemical pharmacology 1992;43(4):793-802.
1991: Ian A Cotgreave; P Moldéus; Lars Engman; Anders Hallberg
The correlation of the oxidation potentials of structurally related dibenzo[1,4]dichalcogenines to their antioxidance capacity in biological systems undergoing free radical-induced lipid peroxidation.
Biochemical pharmacology 1991;42(7):1481-5.
1991: Y Nakagawa; Ian A Cotgreave; P Moldéus
Relationships between ascorbic acid and alpha-tocopherol during diquat-induced redox cycling in isolated rat hepatocytes.
Biochemical pharmacology 1991;42(4):883-8.
1991: Y Liu; Kristina Arvidson; Luigi Atzori; K Sundqvist; B Silva; Ian A Cotgreave; Roland C Grafström
Development of low- and high-serum culture conditions for use of human oral fibroblasts in toxicity testing of dental materials.
Journal of dental research 1991;70(7):1068-73.
1991: Ian A Cotgreave; P Moldéus; I Schuppe
The metabolism of N-acetylcysteine by human endothelial cells.
Biochemical pharmacology 1991;42(1):13-6.
1991: D Constantin; Bengt Jernström; Ian A Cotgreave; P Moldeus
Sodium nitrite-stimulated metabolic activation of benzo[a]pyrene 7,8-dihydrodiol in human polymorphonuclear leukocytes.
Carcinogenesis 1991;12(5):777-81.
1990: Y P Sun; Ian A Cotgreave; B Lindeke; P Moldéus
The protective effect of sulfite on menadione- and diquat-induced cytotoxicity in isolated rat hepatocytes.
Pharmacology & toxicology 1990;66(5):393-8.
1990: Luigi Atzori; J M Dypbukt; K Sundqvist; Ian A Cotgreave; C C Edman; P Moldéus; Roland C Grafström
Growth-associated modifications of low-molecular-weight thiols and protein sulfhydryls in human bronchial fibroblasts.
Journal of cellular physiology 1990;143(1):165-71.
1990: M Weis; G A Moore; Ian A Cotgreave; S D Nelson; P Moldeus
Quinone imine-induced Ca2+ release from isolated rat liver mitochondria.
Chemico-biological interactions 1990;76(2):227-40.
1989: Y P Sun; Ian A Cotgreave; B Lindeke; P Moldéus
The metabolism of sulfite in liver. Stimulation of sulfate conjugation and effects on paracetamol and allyl alcohol toxicity.
Biochemical pharmacology 1989;38(23):4299-305.
1989: Ian A Cotgreave; S K Duddy; G E Kass; D Thompson; P Moldéus
Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?
Biochemical pharmacology 1989;38(4):649-56.
1989: Pierluigi Nicotera; M Rundgren; D J Porubek; Ian A Cotgreave; P Moldéus; Sten Orrenius; S D Nelson
On the role of Ca2+ in the toxicity of alkylating and oxidizing quinone imines in isolated hepatocytes.
Chemical research in toxicology 1989;2(1):46-50.
1988: M Rundgren; D J Porubek; P J Harvison; Ian A Cotgreave; P Moldéus; S D Nelson
Comparative cytotoxic effects of N-acetyl-p-benzoquinone imine and two dimethylated analogues.
Molecular pharmacology 1988;34(4):566-72.
1988: Ian A Cotgreave; U Johansson; P Moldéus; Ralph Brattsand
Lung and systemic thiol homeostasis during an acute lung inflammation in the rat.
Toxicology 1988;50(3):331-43.
1988: Ian A Cotgreave; M Weis; Margareta I Berggren; M S Sandy; P W Moldéus
Determination of the intracellular protein thiol distribution of hepatocytes using monobromobimane derivatisation of intact cells and isolated subcellular fractions.
Journal of biochemical and biophysical methods 1988;16(4):247-54.
1988: Ian A Cotgreave; U Johansson; G Westergren; P W Moldéus; Ralph Brattsand
The anti-inflammatory activity of Ebselen but not thiols in experimental alveolitis and bronchiolitis.
Agents and actions 1988;24(3-4):313-9.
1987: Ian A Cotgreave; M S Sandy; Margareta I Berggren; P W Moldéus; M T Smith
N-acetylcysteine and glutathione-dependent protective effect of PZ51 (Ebselen) against diquat-induced cytotoxicity in isolated hepatocytes.
Biochemical pharmacology 1987;36(18):2899-904.
1987: Ian A Cotgreave; Margareta I Berggren; T W Jones; J Dawson; P Moldéus
Gastrointestinal metabolism of N-acetylcysteine in the rat, including an assay for sulfite in biological systems.
Biopharmaceutics & drug disposition 1987;8(4):377-86.
1987: Ian A Cotgreave; P Moldéus
Lung protection by thiol-containing antioxidants.
Bulletin européen de physiopathologie respiratoire 1987;23(4):275-7.