FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Shaun Coughlin

Research Profile

Chemicals & Drugs

Living Beings

Physiology

Concepts & Ideas

Molecular Sequence Data

Genes & Molecular Sequences

Amino Acid Sequences

Anatomy

Phenomena

Phosphorylation

Procedures

Cloning, Molecular

Co-author Network

Publications

TOP 3
Huanghe Yang; Tong Cheng; Shaun R Coughlin; Tovo David; Fen Huang; Yuh Nung Jan; Taihao Jin; Andrew Kim; Daniel Palmer; Jason Tien; Lily Yeh Jan
TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation.
Bojing Shao; Ajit Varki; Mark G Wahrenbrock; Lijun Xia; Longbiao Yao; Shaun R Coughlin; Tovo David; Rodger P McEver
Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome.
Jesse A Green; Daniel Palmer; Richard L Proia; Timothy H Schmidt; Kazuhiro Suzuki; L David Willison; Ying Xu; Christopher D C Allen; Bryan Cho; Shaun R Coughlin; Jason G Cyster
The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Shaun Coughlin (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2012: Huanghe Yang; Tong Cheng; Shaun R Coughlin; Tovo David; Fen Huang; Yuh Nung Jan; Taihao Jin; Andrew Kim; Daniel Palmer; Jason Tien; Lily Yeh Jan
TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation.
Cell 2012;151(1):111-22.
2011: Bojing Shao; Ajit Varki; Mark G Wahrenbrock; Lijun Xia; Longbiao Yao; Shaun R Coughlin; Tovo David; Rodger P McEver
Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome.
Blood 2011;118(15):4015-23.
2011: Jesse A Green; Daniel Palmer; Richard L Proia; Timothy H Schmidt; Kazuhiro Suzuki; L David Willison; Ying Xu; Christopher D C Allen; Bryan Cho; Shaun R Coughlin; Jason G Cyster
The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement.
Nature immunology 2011;12(7):672-80.
2010: Ivo Cornelissen; Daniel Palmer; Tovo David; Lisa Wilsbacher; Cherry Concengco; Pamela Conley; Anjali Pandey; Shaun R Coughlin
Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(43):18605-10.
2010: Eric Camerer; Adrian Barker; Daniel N Duong; Rajkumar Ganesan; Hiroshi Kataoka; Ivo Cornelissen; Molly R Darragh; Arif Hussain; Yao-Wu Zheng; Yoga Srinivasan; Christopher Brown; Shan-Mei Xu; Jean B Regard; Chen-Yong Lin; Charles S Craik; Daniel Kirchhofer; Shaun R Coughlin
Local protease signaling contributes to neural tube closure in the mouse embryo.
Developmental cell 2010;18(1):25-38.
2010: Trung H M Pham; Peter Baluk; Ying Xu; Irina L Grigorova; Alexander J Bankovich; Rajita Pappu; Shaun R Coughlin; Donald M McDonald; Susan R Schwab; Jason G Cyster
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning.
The Journal of experimental medicine 2010;207(1):17-27.
2009: Eric Camerer; Jean B Regard; Ivo Cornelissen; Yoga Srinivasan; Daniel N Duong; Daniel Palmer; Trung H Pham; Jinny S Wong; Rajita Pappu; Shaun R Coughlin
Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice.
The Journal of clinical investigation 2009;119(7):1871-9.
2008: Jean B Regard; Isaac T Sato; Shaun R Coughlin
Anatomical profiling of G protein-coupled receptor expression.
Cell 2008;135(3):561-71.
2008: Jaehyung Cho; Barbara C Furie; Shaun R Coughlin; Bruce Furie
A critical role for extracellular protein disulfide isomerase during thrombus formation in mice.
The Journal of clinical investigation 2008;118(3):1123-31.
2007: Jean B Regard; Hiroshi Kataoka; David A Cano; Eric Camerer; Liya Yin; Yao-Wu Zheng; Thomas S Scanlan; Matthias Hebrok; Shaun R Coughlin
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.
The Journal of clinical investigation 2007;117(12):4034-43.
2007: Graeme S Cottrell; Silvia Amadesi; Stella Pikios; Eric Camerer; J Adam Willardsen; Brett R Murphy; George H Caughey; Paul wolters; Shaun R Coughlin; Anders Peterson; Wolfgang Knecht; Charalabos Pothoulakis; Nigel W Bunnett; Eileen F Grady
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.
Gastroenterology 2007;132(7):2422-37.
2007: Rajita Pappu; Susan R Schwab; Ivo Cornelissen; João P Pereira; Jean B Regard; Ying Xu; Eric Camerer; Yao-Wu Zheng; Yong Huang; Jason G Cyster; Shaun R Coughlin
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate.
Science (New York, N.Y.) 2007;316(5822):295-8.
2007: Erik R Vandendries; Justin R Hamilton; Shaun R Coughlin; Bruce Furie; Barbara C Furie
Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(1):288-92.
2006: Eric Camerer; Ivo Cornelissen; Hiroshi Kataoka; Daniel N Duong; Yao-Wu Zheng; Shaun R Coughlin
Roles of protease-activated receptors in a mouse model of endotoxemia.
Blood 2006;107(10):3912-21.
2005: Xiao Su; Eric Camerer; Justin R Hamilton; Shaun R Coughlin; Michael A Matthay
Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(4):2598-605.
2005: Shaun R Coughlin
Protease-activated receptors in hemostasis, thrombosis and vascular biology.
Journal of thrombosis and haemostasis : JTH 2005;3(8):1800-14.
2005: Kathleen M Ruppel; David Willison; Hiroshi Kataoka; Alice Wang; Yao-Wu Zheng; Ivo Cornelissen; Liya Yin; Shan-Mei Xu; Shaun R Coughlin
Essential role for Galpha13 in endothelial cells during embryonic development.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8281-6.
2005: Matthew J Ludeman; Hiroshi Kataoka; Yoga Srinivasan; Naomi L Esmon; Charles T Esmon; Shaun R Coughlin
PAR1 cleavage and signaling in response to activated protein C and thrombin.
The Journal of biological chemistry 2005;280(13):13122-8.
2004: Justin R Hamilton; Ivo Cornelissen; Shaun R Coughlin
Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets.
Journal of thrombosis and haemostasis : JTH 2004;2(8):1429-35.
2004: Eric Camerer; Aisha A Qazi; Daniel N Duong; Ivo Cornelissen; Rommel Advincula; Shaun R Coughlin
Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis.
Blood 2004;104(2):397-401.
2004: Matthew J Ludeman; Yao-Wu Zheng; Kenji Ishii; Shaun R Coughlin
Regulated shedding of PAR1 N-terminal exodomain from endothelial cells.
The Journal of biological chemistry 2004;279(18):18592-9.
2004: Eric Camerer; Daniel N Duong; Justin R Hamilton; Shaun R Coughlin
Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency.
Blood 2004;103(1):152-4.
2003: Hiroshi Kataoka; Justin R Hamilton; David D McKemy; Eric Camerer; Yao-Wu Zheng; Abby Cheng; Courtney Griffin; Shaun R Coughlin
Protease-activated receptors 1 and 4 mediate thrombin signaling in endothelial cells.
Blood 2003;102(9):3224-31.
2003: Shaun R Coughlin; Eric Camerer
PARticipation in inflammation.
The Journal of clinical investigation 2003;111(1):25-7.
2002: Ethan J Weiss; Justin R Hamilton; Katy E Lease; Shaun R Coughlin
Protection against thrombosis in mice lacking PAR3.
Blood 2002;100(9):3240-4.
2002: Eric Camerer; Hiroshi Kataoka; Mark Kahn; Katy Lease; Shaun R Coughlin
Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells.
The Journal of biological chemistry 2002;277(18):16081-7.
2002: Shaun R Coughlin
Protease-activated receptors in the cardiovascular system.
Cold Spring Harbor symposia on quantitative biology 2002;67():197-208.
2001: Gilberto R Sambrano; Ethan J Weiss; Yao-Wu Zheng; W Huang; Shaun R Coughlin
Role of thrombin signalling in platelets in haemostasis and thrombosis.
Nature 2001;413(6851):74-8.
2001: C T Griffin; Y Srinivasan; Yao-Wu Zheng; W Huang; Shaun R Coughlin
A role for thrombin receptor signaling in endothelial cells during embryonic development.
Science (New York, N.Y.) 2001;293(5535):1666-70.
2001: Shaun R Coughlin
Protease-activated receptors in vascular biology.
Thrombosis and haemostasis 2001;86(1):298-307.
2000: Jonathan R Lindner; Mark L Kahn; Shaun R Coughlin; Gilberto R Sambrano; E Schauble; D Bernstein; DS Foy; Ali Hafezi-Moghadam; Klaus Ley
Delayed onset of inflammation in protease-activated receptor-2-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6504-10.
2000: JoAnn Trejo; Y Altschuler; H W Fu; Keith E Mostov; Shaun R Coughlin
Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits.
The Journal of biological chemistry 2000;275(40):31255-65.
2000: Shaun R Coughlin
Thrombin signalling and protease-activated receptors.
Nature 2000;407(6801):258-64.
2000: T Takeuchi; Jennifer L Harris; W Huang; K W Yan; Shaun R Coughlin; Charles S Craik
Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates.
The Journal of biological chemistry 2000;275(34):26333-42.
2000: MJ Shapiro; Ethan J Weiss; TR Faruqi; Shaun R Coughlin
Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin.
The Journal of biological chemistry 2000;275(33):25216-21.
2000: TR Faruqi; Ethan J Weiss; MJ Shapiro; W Huang; Shaun R Coughlin
Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function.
The Journal of biological chemistry 2000;275(26):19728-34.
2000: Eric Camerer; W Huang; Shaun R Coughlin
Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5255-60.
2000: M Nakanishi-Matsui; Yao-Wu Zheng; D J Sulciner; Ethan J Weiss; Matthew J Ludeman; Shaun R Coughlin
PAR3 is a cofactor for PAR4 activation by thrombin.
Nature 2000;404(6778):609-13.
2000: Gilberto R Sambrano; W Huang; TR Faruqi; Sami Mahrus; Charles S Craik; Shaun R Coughlin
Cathepsin G activates protease-activated receptor-4 in human platelets.
The Journal of biological chemistry 2000;275(10):6819-23.
1999: Mark L Kahn; T G Diacovo; D F Bainton; F Lanza; JoAnn Trejo; Shaun R Coughlin
Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype.
Blood 1999;94(12):4112-21.
1999: Shaun R Coughlin
How the protease thrombin talks to cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11023-7.
1999: Shaun R Coughlin
Protease-activated receptors and platelet function.
Thrombosis and haemostasis 1999;82(2):353-6.
1999: SR Hammes; MJ Shapiro; Shaun R Coughlin
Shutoff and agonist-triggered internalization of protease-activated receptor 1 can be separated by mutation of putative phosphorylation sites in the cytoplasmic tail.
Biochemistry 1999;38(29):9308-16.
1999: Gilberto R Sambrano; Shaun R Coughlin
The carboxyl tail of protease-activated receptor-1 is required for chemotaxis. Correlation of signal termination and directional migration.
The Journal of biological chemistry 1999;274(29):20178-84.
1999: Mark L Kahn; M Nakanishi-Matsui; M J Shapiro; H Ishihara; Shaun R Coughlin
Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.
The Journal of clinical investigation 1999;103(6):879-87.
1999: SR Hammes; Shaun R Coughlin
Protease-activated receptor-1 can mediate responses to SFLLRN in thrombin-desensitized cells: evidence for a novel mechanism for preventing or terminating signaling by PAR1's tethered ligand.
Biochemistry 1999;38(8):2486-93.
1999: JoAnn Trejo; Shaun R Coughlin
The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling.
The Journal of biological chemistry 1999;274(4):2216-24.
1998: JoAnn Trejo; SR Hammes; Shaun R Coughlin
Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13698-702.
1998: MJ Shapiro; Shaun R Coughlin
Separate signals for agonist-independent and agonist-triggered trafficking of protease-activated receptor 1.
The Journal of biological chemistry 1998;273(44):29009-14.
1998: Mark L Kahn; SR Hammes; C Botka; Shaun R Coughlin
Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.
The Journal of biological chemistry 1998;273(36):23290-6.
1998: Mark L Kahn; Yao-Wu Zheng; W Huang; V Bigornia; D Zeng; S Moff; Robert V Farese; Carmen Tam-Amersdorfer; Shaun R Coughlin
A dual thrombin receptor system for platelet activation.
Nature 1998;394(6694):690-4.
1998: H Ishihara; D Zeng; AJ Connolly; Carmen Tam-Amersdorfer; Shaun R Coughlin
Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin.
Blood 1998;91(11):4152-7.
1998: Shaun R Coughlin
Sol Sherry lecture in thrombosis: how thrombin 'talks' to cells: molecular mechanisms and roles in vivo.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(4):514-8.
1998: Harold S Bernstein; Shaun R Coughlin
A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry.
The Journal of biological chemistry 1998;273(8):4666-71.
1997: AJ Connolly; DY Suh; Thomas K Hunt; Shaun R Coughlin
Mice lacking the thrombin receptor, PAR1, have normal skin wound healing.
The American journal of pathology 1997;151(5):1199-204.
1997: H Ishihara; AJ Connolly; D Zeng; Mark L Kahn; Yao-Wu Zheng; C Timmons; T Tram; Shaun R Coughlin
Protease-activated receptor 3 is a second thrombin receptor in humans.
Nature 1997;386(6624):502-6.
1997: S Verrall; M Ishii; M Chen; L Wang; T Tram; Shaun R Coughlin
The thrombin receptor second cytoplasmic loop confers coupling to Gq-like G proteins in chimeric receptors. Additional evidence for a common transmembrane signaling and G protein coupling mechanism in G protein-coupled receptors.
The Journal of biological chemistry 1997;272(11):6898-902.
1997: M Molino; D F Bainton; James A Hoxie; Shaun R Coughlin; Lawrence F Brass
Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation.
The Journal of biological chemistry 1997;272(9):6011-7.
1997: Harold S Bernstein; Shaun R Coughlin
Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling.
The Journal of biological chemistry 1997;272(9):5833-7.
1996: MJ Shapiro; JoAnn Trejo; D Zeng; Shaun R Coughlin
Role of the thrombin receptor's cytoplasmic tail in intracellular trafficking. Distinct determinants for agonist-triggered versus tonic internalization and intracellular localization.
The Journal of biological chemistry 1996;271(51):32874-80.
1996: C Franci; J Gosling; Chia-Lin Tsou; Shaun R Coughlin; Israel F Charo
Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5606-12.
1996: JoAnn Trejo; A J Connolly; Shaun R Coughlin
The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice.
The Journal of biological chemistry 1996;271(35):21536-41.
1996: D J Lerner; M Chen; T Tram; Shaun R Coughlin
Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function.
The Journal of biological chemistry 1996;271(24):13943-7.
1996: A J Connolly; H Ishihara; Mark L Kahn; Robert V Farese; Shaun R Coughlin
Role of the thrombin receptor in development and evidence for a second receptor.
Nature 1996;381(6582):516-9.
1996: M Kahn; K Ishii; Wen-Lin Kuo; M Piper; A Connolly; Y P Shi; R Wu; C C Lin; Shaun R Coughlin
Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster.
Molecular medicine (Cambridge, Mass.) 1996;2(3):349-57.
1996: Stephan Böhm; W Kong; D Bromme; S P Smeekens; D C Anderson; A Connolly; M Kahn; Nicolas Nelken; Shaun R Coughlin; DG Payan; Nigel W Bunnett
Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2.
The Biochemical journal 1996;314 ( Pt 3)():1009-16.
1996: T Nanevicz; L Wang; M Chen; M Ishii; Shaun R Coughlin
Thrombin receptor activating mutations. Alteration of an extracellular agonist recognition domain causes constitutive signaling.
The Journal of biological chemistry 1996;271(2):702-6.
1995: J Chen; Harold S Bernstein; M Chen; L Wang; M Ishii; Christoph W Turck; Shaun R Coughlin
Tethered ligand library for discovery of peptide agonists.
The Journal of biological chemistry 1995;270(40):23398-401.
1995: T Nanevicz; M Ishii; L Wang; M Chen; J Chen; Christoph W Turck; Fred Cohen; Shaun R Coughlin
Mechanisms of thrombin receptor agonist specificity. Chimeric receptors and complementary mutations identify an agonist recognition site.
The Journal of biological chemistry 1995;270(37):21619-25.
1995: K Ishii; R Gerszten; Yao-Wu Zheng; J B Welsh; Christoph W Turck; Shaun R Coughlin
Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate.
The Journal of biological chemistry 1995;270(27):16435-40.
1994: Shaun R Coughlin
Molecular mechanisms of thrombin signaling.
Seminars in hematology 1994;31(4):270-7.
1994: Shaun R Coughlin
Protease-activated receptors start a family.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9200-2.
1994: J Chen; M Ishii; L Wang; K Ishii; Shaun R Coughlin
Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode.
The Journal of biological chemistry 1994;269(23):16041-5.
1994: R E Gerszten; J Chen; M Ishii; K Ishii; L Wang; T Nanevicz; Christoph W Turck; T K Vu; Shaun R Coughlin
Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface.
Nature 1994;368(6472):648-51.
1994: Shaun R Coughlin
Expanding horizons for receptors coupled to G proteins: diversity and disease.
Current opinion in cell biology 1994;6(2):191-7.
1994: Israel F Charo; S J Myers; A Herman; C Franci; A J Connolly; Shaun R Coughlin
Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2752-6.
1994: Shaun R Coughlin
Thrombin receptor function and cardiovascular disease.
Trends in cardiovascular medicine 1994;4(2):77-83.
1994: K Ishii; J Chen; M Ishii; Walter J Koch; N J Freedman; R J Lefkowitz; Shaun R Coughlin
Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases.
The Journal of biological chemistry 1994;269(2):1125-30.
1994: Scott J Soifer; Kevin G Peters; J O'Keefe; Shaun R Coughlin
Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development.
The American journal of pathology 1994;144(1):60-9.
1993: Shaun R Coughlin
Thrombin receptor structure and function.
Thrombosis and haemostasis 1993;70(1):184-7.
1993: K Ishii; L Hein; B Kobilka; Shaun R Coughlin
Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling.
The Journal of biological chemistry 1993;268(13):9780-6.
1992: D T Hung; Y H Wong; T K Vu; Shaun R Coughlin
The cloned platelet thrombin receptor couples to at least two distinct effectors to stimulate phosphoinositide hydrolysis and inhibit adenylyl cyclase.
The Journal of biological chemistry 1992;267(29):20831-4.
1992: Nicolas Nelken; Scott J Soifer; J O'Keefe; T K Vu; Israel F Charo; Shaun R Coughlin
Thrombin receptor expression in normal and atherosclerotic human arteries.
The Journal of clinical investigation 1992;90(4):1614-21.
1992: Robert M Scarborough; M A Naughton; W Teng; D T Hung; J Rose; T K Vu; V I Wheaton; Christoph W Turck; Shaun R Coughlin
Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function.
The Journal of biological chemistry 1992;267(19):13146-9.
1992: D T Hung; T K Vu; V I Wheaton; K Ishii; Shaun R Coughlin
Cloned platelet thrombin receptor is necessary for thrombin-induced platelet activation.
The Journal of clinical investigation 1992;89(4):1350-3.
1992: D T Hung; T K Vu; V I Wheaton; Israel F Charo; Nicolas Nelken; N Esmon; Charles T Esmon; Shaun R Coughlin
"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure.
The Journal of clinical investigation 1992;89(2):444-50.
1992: Shaun R Coughlin; T K Vu; D T Hung; V I Wheaton
Characterization of a functional thrombin receptor. Issues and opportunities.
The Journal of clinical investigation 1992;89(2):351-5.
1992: D T Hung; T H Vu; Nicolas Nelken; Shaun R Coughlin
Thrombin-induced events in non-platelet cells are mediated by the unique proteolytic mechanism established for the cloned platelet thrombin receptor.
The Journal of cell biology 1992;116(3):827-32.
1992: Shaun R Coughlin; Robert M Scarborough; T K Vu; D T Hung
Thrombin receptor structure and function.
Cold Spring Harbor symposia on quantitative biology 1992;57():149-54.
1992: Shaun R Coughlin; T K Vu; D T Hung; V I Wheaton
Expression cloning and characterization of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
Seminars in thrombosis and hemostasis 1992;18(2):161-6.
1991: T K Vu; V I Wheaton; D T Hung; Israel F Charo; Shaun R Coughlin
Domains specifying thrombin-receptor interaction.
Nature 1991;353(6345):674-7.
1991: Nicolas Nelken; Shaun R Coughlin; David F Gordon; Josiah N Wilcox
Monocyte chemoattractant protein-1 in human atheromatous plaques.
The Journal of clinical investigation 1991;88(4):1121-7.
1991: L W Liu; T K Vu; Charles T Esmon; Shaun R Coughlin
The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity.
The Journal of biological chemistry 1991;266(26):16977-80.
1991: T K Vu; D T Hung; V I Wheaton; Shaun R Coughlin
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.
Cell 1991;64(6):1057-68.
1989: Shaun R Coughlin; J A Escobedo; LT Williams
Role of phosphatidylinositol kinase in PDGF receptor signal transduction.
Science (New York, N.Y.) 1989;243(4895):1191-4.
1988: WM Kavanaugh; LT Williams; Harlan E Ives; Shaun R Coughlin
Serotonin-induced deoxyribonucleic acid synthesis in vascular smooth muscle cells involves a novel, pertussis toxin-sensitive pathway.
Molecular endocrinology (Baltimore, Md.) 1988;2(7):599-605.
1988: J A Escobedo; S Navankasatussas; L S Cousens; Shaun R Coughlin; G I Bell; LT Williams
A common PDGF receptor is activated by homodimeric A and B forms of PDGF.
Science (New York, N.Y.) 1988;240(4858):1532-4.
1988: Shaun R Coughlin; P J Barr; L S Cousens; L J Fretto; LT Williams
Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo.
The Journal of biological chemistry 1988;263(2):988-93.
1988: LT Williams; J A Escobedo; M T Keating; Shaun R Coughlin
Signal transduction by the platelet-derived growth factor receptor.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 1():455-65.
1988: Shaun R Coughlin; J A Escobedo; LT Williams
Molecular mechanisms of platelet-derived growth factor action.
Progress in clinical and biological research 1988;266():39-45.
1987: LT Williams; J A Escobedo; M T Keating; Shaun R Coughlin
The stimulation of paracrine and autocrine mitogenic pathways by the platelet-derived growth factor receptor.
Journal of cellular physiology. Supplement 1987;Suppl 5():27-30.