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Ian Coupar

Research Profile

Living Beings

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Muscle Contraction

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Drug Dose Response Relationship

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Peristalsis

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Publications

TOP 3
Ian M Coupar; Helen R Irving; Fadi Ayad; Juliana Di Iulio; David T Manallack; Yean Y Tan; Nathalie Tochon-Danguy; Magdy N Iskander
Assessment of the pharmacological properties of 5-methoxyindole derivatives at 5-HT4 receptors.
Teshome Nedi; Paul J White; Ian M Coupar; Helen R Irving
Tissue dependent differences in G-protein coupled receptor kinases associated with 5-HT4 receptor desensitization in the rat gastro-intestinal tract.
Amir Hanna-Elias; David T Manallack; Alla Levit; William Nguyen; Fadi Ayad; Glen Perera; Marina Shapiro; Helen R Irving; Ian M Coupar; Magdy N Iskander
Synthesis, testing and structure-activity studies on a library of 5-HT₄ ligands.

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All Publications

2012: Ian M Coupar; Helen R Irving; Fadi Ayad; Juliana Di Iulio; David T Manallack; Yean Y Tan; Nathalie Tochon-Danguy; Magdy N Iskander
Assessment of the pharmacological properties of 5-methoxyindole derivatives at 5-HT4 receptors.
The Journal of pharmacy and pharmacology 2012;64(8):1099-106.
2011: Teshome Nedi; Paul J White; Ian M Coupar; Helen R Irving
Tissue dependent differences in G-protein coupled receptor kinases associated with 5-HT4 receptor desensitization in the rat gastro-intestinal tract.
Biochemical pharmacology 2011;81(1):123-33.
2010: Amir Hanna-Elias; David T Manallack; Alla Levit; William Nguyen; Fadi Ayad; Glen Perera; Marina Shapiro; Helen R Irving; Ian M Coupar; Magdy N Iskander
Synthesis, testing and structure-activity studies on a library of 5-HT₄ ligands.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2010;6(6):344-54.
2010: A Hanna-Elias; David T Manallack; Isabelle Berque-Bestel; Helen R Irving; Ian M Coupar; Magdy N Iskander
Synthesis and preliminary screening of novel tryptamines as 5-HT4 receptor ligands.
Current medicinal chemistry 2010;17(25):2775-87.
2009: Amir Hanna-Elias; David T Manallack; Isabelle Berque-Bestel; Helen R Irving; Ian M Coupar; Magdy N Iskander
Synthesis and preliminary screening of novel indole-3-methanamines as 5-HT4 receptor ligands.
European journal of medicinal chemistry 2009;44(7):2952-9.
2009: Vijay B Urmaliya; Jarrod E Church; Ian M Coupar; Roselyn B Rose'Meyer; Colin W Pouton; Paul J White
Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine.
Journal of cardiovascular pharmacology 2009;53(5):424-33.
2009: Navinisha Chetty; Ian M Coupar; Yean Yeow Tan; P V Desmond; Helen R Irving
Distribution of serotonin receptors and interacting proteins in the human sigmoid colon.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2009;21(5):551-8, e14-5.
2009: A Hanna-Elias; Philip E Thompson; David T Manallack; Helen R Irving; Ian M Coupar; Isabelle Berque-Bestel; Magdy N Iskander
The use of tripeptides for lead discovery of 5-HT4 receptor ligands.
Protein and peptide letters 2009;16(7):805-9.
2008: Navinisha Chetty; Helen R Irving; Ian M Coupar
Effects of the novel 5-HT3 agonist MKC-733 on the rat, mouse and guinea pig digestive tract.
Pharmacology 2008;81(2):104-9.
2007: Ian M Coupar; Paul V Desmond; Helen R Irving
Human 5-HT(4) and 5-HT(7) receptor splice variants: are they important?
Current neuropharmacology 2007;5(4):224-31.
2007: Navinisha Chetty; Ian M Coupar; R Chess-Williams; Karen P Kerr
Demonstration of 5-HT(3) receptor function and expression in the mouse bladder.
Naunyn-Schmiedeberg's archives of pharmacology 2007;375(6):359-68.
2007: Helen R Irving; Yean Y Tan; Nathalie Tochon-Danguy; Haihuang Liu; Navinisha Chetty; Paul V Desmond; Colin W Pouton; Ian M Coupar
Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon.
Life sciences 2007;80(13):1198-205.
2006: Daniel P Poole; Bo Xu; Shir Lin Koh; Billie Hunne; Ian M Coupar; Helen R Irving; Katsuhiro Shinjo; John B Furness
Identification of neurons that express 5-hydroxytryptamine4 receptors in intestine.
Cell and tissue research 2006;325(3):413-22.
2006: Navinisha Chetty; Helen R Irving; Ian M Coupar
Activation of 5-HT3 receptors in the rat and mouse intestinal tract: a comparative study.
British journal of pharmacology 2006;148(7):1012-21.
2006: Andrew C Gray; Ian M Coupar; Paul J White
Comparison of opioid receptor distributions in the rat central nervous system.
Life sciences 2006;79(7):674-85.
2006: Andrew C Gray; Ian M Coupar; Paul J White
Comparison of opioid receptor distributions in the rat ileum.
Life sciences 2006;78(14):1610-6.
2006: Magdy N Iskander; Lok M Leung; Trevor Buley; Fadi Ayad; Juliana Di Iulio; Yean Y Tan; Ian M Coupar
Optimization of a pharmacophore model for 5-HT4 agonists using CoMFA and receptor based alignment.
European journal of medicinal chemistry 2006;41(1):16-26.
2005: Andrew C Gray; Paul J White; Ian M Coupar
Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum.
British journal of pharmacology 2005;144(5):687-94.
2004: Haihuang Liu; Helen R Irving; Yean Y Tan; L Meng; Navinisha Chetty; Ian M Coupar
Influences of gender and region on responses to 5-HT in the rat small intestine.
Pharmacology 2004;72(4):220-4.
2003: Ian M Coupar; Juliana Di Iulio
Effects of tachykinins and 5-hydroxytryptamine on intestinal secretion.
Clinical and experimental pharmacology & physiology 2003;30(10):764-8.
2003: Haihuang Liu; Ian M Coupar; Helen R Irving
Effects of some antidepressant drugs on tryptaminergic responses of the rat jejunum.
Pharmacology 2003;69(2):88-92.
2002: Ian M Coupar; Binh L T Tran
Effects of adenosine agonists on consumptive behaviour and body temperature.
The Journal of pharmacy and pharmacology 2002;54(2):289-94.
2002: Magdy N Iskander; Y Song; Ian M Coupar; W Jiratchariyakul
Antiinflammatory screening of the medicinal plant Gynura procumbens.
Plant foods for human nutrition (Dordrecht, Netherlands) 2002;57(3-4):233-44.
2001: Haihuang Liu; Helen R Irving; Ian M Coupar
Expression patterns of 5-HT7 receptor isoforms in the rat digestive tract.
Life sciences 2001;69(21):2467-75.
2001: Ian M Coupar; B L Tran
Withdrawal and bidirectional cross-withdrawal responses in rats treated with adenosine agonists and morphine.
Life sciences 2001;69(7):779-90.
2001: M Hemedah; Richard E Loiacono; Ian M Coupar; Frederick Mitchelson
Lack of evidence for histamine H3 receptor function in rat ileum and human colon.
Naunyn-Schmiedeberg's archives of pharmacology 2001;363(2):133-8.
2000: Karen P Kerr; B Thai; Ian M Coupar
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
British journal of pharmacology 2000;131(7):1461-7.
2000: Karen P Kerr; Frederick Mitchelson; Ian M Coupar
Tachykinins play a minor role in mediating the third phase of the contractile response to vagal nerve stimulation of the guinea-pig oesophagus.
Neuropeptides 2000;34(1):12-7.
2000: M Hemedah; Ian M Coupar; Frederick Mitchelson
Characterisation of a 5-HT(7) binding site in mouse ileum.
European journal of pharmacology 2000;387(3):265-72.
1999: Ian M Coupar
Characterization and tissue location of the neural adenosine receptor in the rat ileum.
British journal of pharmacology 1999;126(5):1269-75.
1999: M Hemedah; Ian M Coupar; Frederick Mitchelson
[3H]-Mesulergine labels 5-HT7 sites in rat brain and guinea-pig ileum but not rat jejunum.
British journal of pharmacology 1999;126(1):179-88.
1998: peter g mclean; Ian M Coupar
Investigation into the effect of 5-hydroxytryptamine on fluid transport in the rat small intestine.
General pharmacology 1998;30(2):227-31.
1998: M Hemedah; Frederick Mitchelson; Ian M Coupar
Evidence of H3 receptor inhibition by iodoaminopotentidine in the guinea pig ileum.
Life sciences 1998;63(15):1371-6.
1997: L Liu; Ian M Coupar
Involvement of alpha-2 adrenoceptors in the effects of moxonidine on intestinal motility and fluid transport.
The Journal of pharmacology and experimental therapeutics 1997;283(3):1367-74.
1997: L Liu; Ian M Coupar
Characterisation of pre- and post-synaptic alpha-adrenoceptors in modulation of the rat ileum longitudinal and circular muscle activities.
Naunyn-Schmiedeberg's archives of pharmacology 1997;356(2):248-56.
1997: D L Hancock; Ian M Coupar
Studies investigating the possible involvement of adenosine in the antisecretory action of morphine.
General pharmacology 1997;28(5):709-13.
1997: L Liu; Ian M Coupar
Role of alpha 2-adrenoceptors in the regulation of intestinal water transport.
British journal of pharmacology 1997;120(5):892-8.
1997: Karen P Kerr; Frederick Mitchelson; Ian M Coupar
Tachykinin receptors in the guinea-pig isolated oesophagus: a complex system.
British journal of pharmacology 1997;120(6):1021-8.
1996: Ian M Coupar; L Liu
A simple method for measuring the effects of drugs on intestinal longitudinal and circular muscle.
Journal of pharmacological and toxicological methods 1996;36(3):147-54.
1996: peter g mclean; Ian M Coupar; P Molenaar
Changes in sensitivity of 5-HT receptor mediated functional responses in the rat oesophagus, fundus and jejunum following chronic infusion with 5-hydroxytryptamine.
Naunyn-Schmiedeberg's archives of pharmacology 1996;354(4):513-9.
1996: peter g mclean; Ian M Coupar
Characterisation of a postjunctional 5-ht7-like and a prejunctional 5-HT3 receptor mediating contraction of rat isolated jejunum.
European journal of pharmacology 1996;312(2):215-25.
1996: peter g mclean; Ian M Coupar
Further investigation into the signal transduction mechanism of the 5-HT4-like receptor in the circular smooth muscle of human colon.
British journal of pharmacology 1996;118(4):1058-64.
1996: L Liu; Ian M Coupar
Evidence for functional alpha 2D-adrenoceptors in the rat intestine.
British journal of pharmacology 1996;117(5):787-92.
1996: peter g mclean; Ian M Coupar
Stimulation of cyclic AMP formation in the circular smooth muscle of human colon by activation of 5-HT4-like receptors.
British journal of pharmacology 1996;117(2):238-9.
1995: Ian M Coupar
The peristaltic reflex in the rat ileum: evidence for functional mu- and delta-opiate receptors.
The Journal of pharmacy and pharmacology 1995;47(8):643-6.
1995: peter g mclean; Ian M Coupar
5-HT4 receptor antagonist affinities of SB207710, SB205008, and SB203186 in the human colon, rat oesophagus, and guinea-pig ileum peristaltic reflex.
Naunyn-Schmiedeberg's archives of pharmacology 1995;352(2):132-40.
1995: D L Hancock; Ian M Coupar
Functional characterization of the adenosine receptor mediating inhibition of peristalsis in the rat jejunum.
British journal of pharmacology 1995;115(5):739-44.
1995: D L Hancock; Ian M Coupar
Evidence for peptidase activity in the rat intestine.
Journal of autonomic pharmacology 1995;15(3):197-204.
1995: K P Kerr; Frederick Mitchelson; Ian M Coupar
Vagal nerve stimulation of the guinea-pig oesophagus.
Acta physiologica Scandinavica 1995;154(2):213-20.
1995: peter g mclean; Ian M Coupar; P Molenaar
A comparative study of functional 5-HT4 receptors in human colon, rat oesophagus and rat ileum.
British journal of pharmacology 1995;115(1):47-56.
1995: D L Hancock; Ian M Coupar
Functional characterization of the adenosine receptor mediating inhibition of intestinal secretion.
British journal of pharmacology 1995;114(1):152-6.
1994: D L Hancock; Ian M Coupar
Evidence for functional delta-opiate receptors in the rat intestine.
The Journal of pharmacy and pharmacology 1994;46(10):805-8.
1994: Ian M Coupar; D L Hancock
The adenosine agonist NECA inhibits intestinal secretion and peristalsis.
The Journal of pharmacy and pharmacology 1994;46(10):801-4.
1994: Ian M Coupar; A De Luca
Opiate and opiate antidiarrhoeal drug action on rat isolated intestine.
Journal of autonomic pharmacology 1994;14(1):69-78.
1994: A de Luca; N V Korszniak; Ian M Coupar
Opiate agonist and antagonist action on guinea-pig isolated ileum.
General pharmacology 1994;25(1):79-83.
1993: peter g mclean; Ian M Coupar; P Molenaar
Effect of the novel 5-HT4 receptor agonist DAU 6236 in human colon.
The Medical journal of Australia 1993;159(11-12):834.
1993: A De Luca; G Murray; Ian M Coupar
Do antidiarrhoeal opiates accumulate in the rat intestinal lumen?
The Journal of pharmacy and pharmacology 1993;45(12):1082-4.
1992: T Dionyssopoulos; W Hope; Ian M Coupar
Effect of adenosine analogues on the expression of opiate withdrawal in rats.
Pharmacology, biochemistry, and behavior 1992;42(2):201-6.
1991: J Margaritis; Ian M Coupar; G A Bentley
Studies to determine whether there is tolerance or cross-tolerance to the antisecretory effect of morphine and clonidine in the rat intestine.
The Journal of pharmacy and pharmacology 1991;43(9):655-8.
1990: E Beubler; Ian M Coupar; J Hardcastle; PT Hardcastle
Stimulatory effects of 5-hydroxytryptamine on fluid secretion and transmural potential difference in rat small intestine are mediated by different receptor subtypes.
The Journal of pharmacy and pharmacology 1990;42(1):35-9.
1988: Nicola J Brown; Ian M Coupar; R D Rumsey
The effect of acute and chronic administration of morphine and morphine withdrawal on intestinal transit time in the rat.
The Journal of pharmacy and pharmacology 1988;40(12):844-8.
1988: Ian M Coupar; J Hardcastle; PT Hardcastle
The response of the intestinal mucosa to prostaglandin E2 during withdrawal from morphine.
The Journal of pharmacy and pharmacology 1988;40(4):262-6.