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Charles Coutelle

Research Profile

Procedures

Genetic Therapy

Chemicals & Drugs

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Gene Transfer Techniques

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Ali Nowrouzi; Emma Osejindu; Anna Paruzynski; Safia Reja; Terry P Roberts; Alaine Ruthe; Manfred Schmidt; Michael Themis; Faisal Al-Allaf; Robert Andrews; Anne Arens; Brian Bigger; Suzanne Mk Buckley; Wing T Cheung; Charles Coutelle; Niraja Dighe; Lisa Gregory; Maxine Holder; Tingting Li; Eugenio Montini; Robert F Newbold; Adrian J Thrasher; Christof von Kalle; Simon Waddington; Yoahe Wang; Xuegong Zhang; Mike Themis
The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis.
Charles Coutelle; Richard Ashcroft
Risks, benefits and ethical, legal, and societal considerations for translation of prenatal gene therapy to human application.
Charles Coutelle; Simon Waddington; Michael Themis
Monitoring for potential adverse effects of prenatal gene therapy: mouse models for developmental aberrations and inadvertent germ line transmission.

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All Publications

2013: Ali Nowrouzi; Emma Osejindu; Anna Paruzynski; Safia Reja; Terry P Roberts; Alaine Ruthe; Manfred Schmidt; Michael Themis; Faisal Al-Allaf; Robert Andrews; Anne Arens; Brian Bigger; Suzanne Mk Buckley; Wing T Cheung; Charles Coutelle; Niraja Dighe; Lisa Gregory; Maxine Holder; Tingting Li; Eugenio Montini; Robert F Newbold; Adrian J Thrasher; Christof von Kalle; Simon Waddington; Yoahe Wang; Xuegong Zhang; Mike Themis
The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(2):324-37.
2012: Charles Coutelle; Richard Ashcroft
Risks, benefits and ethical, legal, and societal considerations for translation of prenatal gene therapy to human application.
Methods in molecular biology (Clifton, N.J.) 2012;891():371-87.
2012: Charles Coutelle; Simon Waddington; Michael Themis
Monitoring for potential adverse effects of prenatal gene therapy: mouse models for developmental aberrations and inadvertent germ line transmission.
Methods in molecular biology (Clifton, N.J.) 2012;891():329-40.
2012: Vedanta Mehta; Donald M Peebles; Simon Waddington; Jacqueline Wallace; Khalil N Abi-Nader; David Carr; Charles Coutelle; Anna L David
Monitoring for potential adverse effects of prenatal gene therapy: use of large animal models with relevance to human application.
Methods in molecular biology (Clifton, N.J.) 2012;891():291-328.
2012: Charles Coutelle; Simon Waddington
Vector systems for prenatal gene therapy: choosing vectors for different applications.
Methods in molecular biology (Clifton, N.J.) 2012;891():41-53.
2012: Charles Coutelle; Simon Waddington
The concept of prenatal gene therapy.
Methods in molecular biology (Clifton, N.J.) 2012;891():1-7.
2011: Brian W Bigger; Ai-Yin Liao; Ana Sergijenko; Charles Coutelle
Trial and error: how the unclonable human mitochondrial genome was cloned in yeast.
Pharmaceutical research 2011;28(11):2863-70.
2011: Massimo Conese; Charles Coutelle; Ida De Fino; Stefaan De Smedt; Joanna Rejman; Joseph Rosenecker; Dirk Schindelhauer; Fiorentina Ascenzioni; A Christopher Boyd; Bob J Scholte
Gene and cell therapy for cystic fibrosis: from bench to bedside.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2011;10 Suppl 2():S114-28.
2011: Orestis Argyros; Suet Ping Wong; Constantinos Fedonidis; Oleg Tolmachov; Simon Waddington; Steven J Howe; Marcello Niceta; Charles Coutelle; Richard P Harbottle
Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver.
Journal of molecular medicine (Berlin, Germany) 2011;89(5):515-29.
2011: Suzanne M K Buckley; Jerry K Y Chan; Charles Coutelle; Anna L David; Donald M Peebles; Ahad A Rahim; Simon N Waddingtont
Recent advances in fetal gene therapy.
Therapeutic delivery 2011;2(4):461-9.
2011: S P Wong; Orestis Argyros; Charles Coutelle; Richard P Harbottle
Non-viral S/MAR vectors replicate episomally in vivo when provided with a selective advantage.
Gene therapy 2011;18(1):82-7.
2010: Ahad A Rahim; Andrew M S Wong; Suzanne M K Buckley; Jerry K Y Chan; Anna L David; Jonathan D Cooper; Charles Coutelle; Donald M Peebles; Simon Waddington
In utero gene transfer to the mouse nervous system.
Biochemical Society transactions 2010;38(6):1489-93.
2010: Anna L David; Khalil N Abi-Nader; boaz weisz; S W Steven Shaw; Michael Themis; Terence Cook; Charles Coutelle; Charles H Rodeck; Donald M Peebles
Ultrasonographic development of the fetal sheep stomach and evaluation of early gestation ultrasound-guided in utero intragastric injection.
Taiwanese journal of obstetrics & gynecology 2010;49(1):23-9.
2010: Faisal A Al-Allaf; Charles Coutelle; Simon N Waddington; Anna L David; Richard Harbottle; Michael Themis
LDLR-Gene therapy for familial hypercholesterolaemia: problems, progress, and perspectives.
International archives of medicine 2010;3():36.
2009: Suet Ping Wong; Orestis Argyros; Charles Coutelle; Richard P Harbottle
Strategies for the episomal modification of cells.
Current opinion in molecular therapeutics 2009;11(4):433-41.
2008: Orestis Argyros; S P Wong; M Niceta; Simon Waddington; S J Howe; Charles Coutelle; Andrew D Miller; Richard P Harbottle
Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector.
Gene therapy 2008;15(24):1593-605.
2008: Suzanne Buckley; Steven J Howe; Ahad A Rahim; Hildegard Buning; Jenny McIntosh; Suet-Ping Wong; Andrew H Baker; Amit Nathwani; Adrian J Thrasher; Charles Coutelle; Tristan R McKay; Simon Waddington
Luciferin detection after intranasal vector delivery is improved by intranasal rather than intraperitoneal luciferin administration.
Human gene therapy 2008;19(10):1050-6.
2008: Suzanne Buckley; S J Howe; V Sheard; N J Ward; Charles Coutelle; Adrian J Thrasher; Simon Waddington; T R McKay
Lentiviral transduction of the murine lung provides efficient pseudotype and developmental stage-dependent cell-specific transgene expression.
Gene therapy 2008;15(16):1167-75.
2008: Suzanne Buckley; Simon Waddington; S Jezzard; A Bergau; Michael Themis; L J MacVinish; alan cuthbert; W H Colledge; Charles Coutelle
Intra-amniotic delivery of CFTR-expressing adenovirus does not reverse cystic fibrosis phenotype in inbred CFTR-knockout mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(5):819-24.
2008: Charles Coutelle
Why bother? Is in utero gene therapy worth the effort?
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(2):219-20.
2007: Simon Waddington; Suzanne Buckley; Anna L David; Donald M Peebles; Charles H Rodeck; Charles Coutelle
Fetal gene transfer.
Current opinion in molecular therapeutics 2007;9(5):432-8.
2007: Olivia C Hibbitt; Richard P Harbottle; Simon Waddington; Christine A Bursill; Charles Coutelle; Keith M Channon; Richard Wade-Martins
Delivery and long-term expression of a 135 kb LDLR genomic DNA locus in vivo by hydrodynamic tail vein injection.
The journal of gene medicine 2007;9(6):488-97.
2007: Oleg Tolmachov; Charles Coutelle
Covalent attachment of multifunctional chimeric terminal proteins to 5' DNA ends: A potential new strategy for assembly of synthetic therapeutic gene vectors.
Medical hypotheses 2007;68(2):328-31.
2006: Anna L David; Donald M Peebles; Lisa G Gregory; Simon Waddington; Michael Themis; boaz weisz; Ali Ruthe; Lorraine Lawrence; Terry Cook; Charles H Rodeck; Charles Coutelle
Clinically applicable procedure for gene delivery to fetal gut by ultrasound-guided gastric injection: toward prenatal prevention of early-onset intestinal diseases.
Human gene therapy 2006;17(7):767-79.
2006: Anna L David; boaz weisz; Lisa G Gregory; Michael Themis; Terry Cook; Xenia I Roubliova; Jan Deprest; Charles Coutelle; Charles H Rodeck; Donald M Peebles
Ultrasound-guided injection and occlusion of the trachea in fetal sheep.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology 2006;28(1):82-8.
2006: Laurence Vaysse; Lisa G Gregory; Richard P Harbottle; Eric Perouzel; Oleg Tolmachov; Charles Coutelle
Nuclear-targeted minicircle to enhance gene transfer with non-viral vectors in vitro and in vivo.
The journal of gene medicine 2006;8(6):754-63.
2006: Oleg Tolmachov; Yu-Ling Ma; Michael Themis; Pravina Patel; Hilmar Spohr; Kenneth T MacLeod; Nina D Ullrich; Yvonne Kienast; Charles Coutelle; Nicholas S Peters
Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro.
BMC cardiovascular disorders 2006;6():25.
2006: Oleg Tolmachov; Iwona Palaszewski; Brian W Bigger; Charles Coutelle
RecET driven chromosomal gene targeting to generate a RecA deficient Escherichia coli strain for Cre mediated production of minicircle DNA.
BMC biotechnology 2006;6():17.
2006: Brian W Bigger; Elena K Siapati; Ajay R Mistry; Simon Waddington; Megha Nivsarkar; L Jacobs; R Perrett; Maxine V Holder; C Ridler; Geoffrey Kemball-Cook; Robin R Ali; Stuart J Forbes; Charles Coutelle; N Wright; Stuart McDonald; Adrian J Thrasher; Dominique Bonnet; Michael Themis
Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX.
Gene therapy 2006;13(2):117-26.
2005: Charles Coutelle; Michael Themis; Simon Waddington; Suzanne Buckley; Lisa G Gregory; Megha Nivsarkar; Anna L David; Donald M Peebles; boaz weisz; Charles Rodeck
Gene therapy progress and prospects: fetal gene therapy--first proofs of concept--some adverse effects.
Gene therapy 2005;12(22):1601-7.
2005: Michael Themis; Simon Waddington; Manfred Schmidt; Christof von Kalle; Yoahe Wang; Faisal Al-Allaf; Lisa G Gregory; Megha Nivsarkar; Matthew Themis; Maxine V Holder; Suzanne Buckley; Niraja Dighe; Ali Ruthe; Ajay R Mistry; Brian W Bigger; Ahad Rahim; Tuan H Nguyen; Didier Trono; Adrian J Thrasher; Charles Coutelle
Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(4):763-71.
2005: boaz weisz; Anna L David; Lisa G Gregory; Dany Perocheau; Ali Ruthe; Simon Waddington; Michael Themis; Terry Cook; Charles Coutelle; Charles H Rodeck; Donald M Peebles
Targeting the respiratory muscles of fetal sheep for prenatal gene therapy for Duchenne muscular dystrophy.
American journal of obstetrics and gynecology 2005;193(3 Pt 2):1105-9.
2005: Suzanne Buckley; Simon Waddington; Sarah Jezzard; Lorraine Lawrence; Holm Schneider; Maxine V Holder; Michael Themis; Charles Coutelle
Factors influencing adenovirus-mediated airway transduction in fetal mice.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;12(3):484-92.
2005: Faisal Al-Allaf; Oleg Tolmachov; Michael Themis; Charles Coutelle
Coupled analysis of bacterial transformants and ligation mixture by duplex PCR enables detection of fatal instability of a nascent recombinant plasmid.
Journal of biochemical and biophysical methods 2005;64(2):142-6.
2005: Jodie E Waterhouse; Richard P Harbottle; Michael Keller; Kostas Kostarelos; Charles Coutelle; Michael R Jorgensen; Andrew D Miller
Synthesis and application of integrin targeting lipopeptides in targeted gene delivery.
Chembiochem : a European journal of chemical biology 2005;6(7):1212-23.
2005: Simon Waddington; M Gabriela Kramer; Ruben Hernandez-Alcoceba; Suzanne Buckley; Michael Themis; Charles Coutelle; Jesus Prieto
In utero gene therapy: current challenges and perspectives.
Molecular therapy : the journal of the American Society of Gene Therapy 2005;11(5):661-76.
2005: Faisal Al-Allaf; Oleg Tolmachov; Michael Themis; Charles Coutelle
Accurate size gauging of ExoIII/S1-generated deletions by PCR analysis of ligation mixtures.
Analytical biochemistry 2005;339(2):348-50.
2005: Jonathan Hoare; Simon Waddington; Howard Thomas; Charles Coutelle; Michael J McGarvey
Complement inhibition rescued mice allowing observation of transgene expression following intraportal delivery of baculovirus in mice.
The journal of gene medicine 2005;7(3):325-33.
2004: Simon Waddington; Megha Nivsarkar; Ajay R Mistry; Suzanne Buckley; Geoffrey Kemball-Cook; Karen L Mosley; Kyriacos A Mitrophanous; Pippa Radcliffe; Maxine V Holder; Mairi Brittan; Anastasios Georgiadis; Faisal Al-Allaf; Brian W Bigger; Lisa G Gregory; H Terence Cook; Robin R Ali; Adrian J Thrasher; Edward G D Tuddenham; Michael Themis; Charles Coutelle
Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy.
Blood 2004;104(9):2714-21.
2004: Simon Waddington; Nigel L Kennea; Suzanne Buckley; Lisa G Gregory; Michael Themis; Charles Coutelle
Fetal and neonatal gene therapy: benefits and pitfalls.
Gene therapy 2004;11 Suppl 1():S92-7.
2004: Lisa G Gregory; Simon Waddington; Maxine V Holder; Kyriacos A Mitrophanous; Suzanne Buckley; Karen L Mosley; Brian W Bigger; Fiona M Ellard; Lucy E Walmsley; Lorraine Lawrence; Faisal Al-Allaf; Susan M Kingsman; Charles Coutelle; Michael Themis
Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy.
Gene therapy 2004;11(14):1117-25.
2004: Simon Waddington; Suzanne Buckley; Christian Bernloehr; Sascha Bossow; Guy Ungerechts; Terry Cook; Lisa G Gregory; Ahad Rahim; Michael Themis; Wolfgang J Neubert; Charles Coutelle; Ulrich M Lauer; Michael Bitzer
Reduced toxicity of F-deficient Sendai virus vector in the mouse fetus.
Gene therapy 2004;11(7):599-608.
2004: Laurence Vaysse; Richard P Harbottle; Brian W Bigger; Anna Bergau; Oleg Tolmachov; Charles Coutelle
Development of a self-assembling nuclear targeting vector system based on the tetracycline repressor protein.
The Journal of biological chemistry 2004;279(7):5555-64.
2004: Donald M Peebles; Lisa G Gregory; Anna David; Michael Themis; Simon Waddington; Holly J Knapton; Maznu Miah; Terry Cook; Lorraine Lawrence; Megha Nivsarkar; Charles Rodeck; Charles Coutelle
Widespread and efficient marker gene expression in the airway epithelia of fetal sheep after minimally invasive tracheal application of recombinant adenovirus in utero.
Gene therapy 2004;11(1):70-8.
2003: Charles Coutelle; Michael Themis; Simon Waddington; Lisa G Gregory; Megha Nivsarkar; S Buckley; Terry Cook; Charles Rodeck; Donald M Peebles; Anna David
The hopes and fears of in utero gene therapy for genetic disease--a review.
Placenta 2003;24 Suppl B():S114-21.
2003: Michael Themis; D May; Charles Coutelle; Robert F Newbold
Mutational effects of retrovirus insertion on the genome of V79 cells by an attenuated retrovirus vector: implications for gene therapy.
Gene therapy 2003;10(19):1703-11.
2003: Anna L David; Donald M Peebles; Lisa G Gregory; Michael Themis; Terry Cook; Charles Coutelle; Charles H Rodeck
Percutaneous ultrasound-guided injection of the trachea in fetal sheep: a novel technique to target the fetal airways.
Fetal diagnosis and therapy 2003;18(5):385-90.
2003: Ahad Rahim; Charles Coutelle; Richard P Harbottle
High-throughput Pyrosequencing of a phage display library for the identification of enriched target-specific peptides.
BioTechniques 2003;35(2):317-20, 322, 324.
2003: Simon Waddington; Kyriacos A Mitrophanous; Fiona M Ellard; Suzanne Buckley; Megha Nivsarkar; Lorraine Lawrence; H Terence Cook; Faisal Al-Allaf; Brian W Bigger; Susan M Kingsman; Charles Coutelle; Michael Themis
Long-term transgene expression by administration of a lentivirus-based vector to the fetal circulation of immuno-competent mice.
Gene therapy 2003;10(15):1234-40.
2003: Michael Keller; Richard P Harbottle; Eric Perouzel; Morvane Colin; Imran Shah; Ahad Rahim; Laurence Vaysse; Anna Bergau; Sylviane Moritz; Christiane Brahimi-Horn; Charles Coutelle; Andrew D Miller
Nuclear localisation sequence templated nonviral gene delivery vectors: investigation of intracellular trafficking events of LMD and LD vector systems.
Chembiochem : a European journal of chemical biology 2003;4(4):286-98.
2003: Anna David; Terry Cook; Simon Waddington; Donald M Peebles; Megha Nivsarkar; Holly J Knapton; Maznu Miah; Thomas Dahse; David Noakes; Holm Schneider; Charles Rodeck; Charles Coutelle; Michael Themis
Ultrasound-guided percutaneous delivery of adenoviral vectors encoding the beta-galactosidase and human factor IX genes to early gestation fetal sheep in utero.
Human gene therapy 2003;14(4):353-64.
2003: Simon Waddington; Suzanne Buckley; Megha Nivsarkar; Sarah Jezzard; Holm Schneider; Thomas Dahse; Geoffrey Kemball-Cook; Maznu Miah; Nicholas P Tucker; Margaret J Dallman; Michael Themis; Charles Coutelle
In utero gene transfer of human factor IX to fetal mice can induce postnatal tolerance of the exogenous clotting factor.
Blood 2003;101(4):1359-66.
2003: Lisa G Gregory; Richard P Harbottle; Lorraine Lawrence; Holly J Knapton; Michael Themis; Charles Coutelle
Enhancement of adenovirus-mediated gene transfer to the airways by DEAE dextran and sodium caprate in vivo.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(1):19-26.
2003: Sylviane Moritz; Morvane Colin; Michael Keller; Bernard Klonjkowski; Jacqueline Capeau; Charles Coutelle; J Chroboczek; Marie Christiane Brahimi-Horn
Gene transfer by adenovirus-mimetic peptides in the presence of a cationic lipid and/or adenovirus. Analysis of the contribution of the viral and nonviral components.
Archives of virology 2003;148(1):1-18.
2002: Charles Coutelle; Charles Rodeck
On the scientific and ethical issues of fetal somatic gene therapy.
Gene therapy 2002;9(11):670-3.
2002: T Tagawa; M Manvell; N Brown; Michael Keller; Eric Perouzel; Karl D Murray; Richard P Harbottle; Miriam Tecle; frank booy; Marie Christiane Brahimi-Horn; Charles Coutelle; Nick Lemoine; Eric W F W Alton; Andrew D Miller
Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide mu and plasmid DNA.
Gene therapy 2002;9(9):564-76.
2002: Tristan McKay; Paul Reynolds; Sarah Jezzard; David Curiel; Charles Coutelle
Secretin-mediated gene delivery, a specific targeting mechanism with potential for treatment of biliary and pancreatic disease in cystic fibrosis.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;5(4):447-54.
2002: Holm Schneider; Christiane Mühle; Anne-Marie Douar; Simon Waddington; Qiu-Jie Jiang; Klaus von der Mark; Charles Coutelle; Wolfgang Rascher
Sustained delivery of therapeutic concentrations of human clotting factor IX--a comparison of adenoviral and AAV vectors administered in utero.
The journal of gene medicine 2002;4(1):46-53.
2001: Morvane Colin; Sylviane Moritz; P Fontanges; Michel Kornprobst; C Delouis; Michael Keller; Andrew D Miller; Jacqueline Capeau; Charles Coutelle; Marie Christiane Brahimi-Horn
The nuclear pore complex is involved in nuclear transfer of plasmid DNA condensed with an oligolysine-RGD peptide containing nuclear localisation properties.
Gene therapy 2001;8(21):1643-53.
2001: Charles Coutelle; Brian W Bigger
[Gene therapy of cystic fibrosis; review of completed clinical studies].
Der Internist 2001;42(10):1346-50, 1353-6.
2001: Brian W Bigger; Oleg Tolmachov; JM Collombet; M Fragkos; I Palaszewski; Charles Coutelle
An araC-controlled bacterial cre expression system to produce DNA minicircle vectors for nuclear and mitochondrial gene therapy.
The Journal of biological chemistry 2001;276(25):23018-27.
2001: L M Chan; Charles Coutelle; Michael Themis
A novel human suspension culture packaging cell line for production of high-titre retroviral vectors.
Gene therapy 2001;8(9):697-703.
2001: P J Jost; Richard P Harbottle; A Knight; Andrew D Miller; Charles Coutelle; Holm Schneider
A novel peptide, THALWHT, for the targeting of human airway epithelia.
FEBS letters 2001;489(2-3):263-9.
2001: Brian W Bigger; Charles Coutelle
Perspectives on gene therapy for cystic fibrosis airway disease.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2001;15(9):615-34.
2001: Charles Coutelle; Michael Themis; Holm Schneider; T Kiserud; Terry Cook; Anne-Marie Douar; M Hanson; A Pavirani; Charles Rodeck
Fetal somatic gene therapy--a preventive approach to the treatment of genetic disease: the case for.
Ernst Schering Research Foundation workshop 2001;(33):99-114.
2000: Holm Schneider; M Groves; Christiane Mühle; P N Reynolds; Andrew Knight; Michael Themis; Jaime Carvajal; F Scaravilli; D T Curiel; Neil Fairweather; Charles Coutelle
Retargeting of adenoviral vectors to neurons using the Hc fragment of tetanus toxin.
Gene therapy 2000;7(18):1584-92.
2000: Morvane Colin; Sylviane Moritz; Holm Schneider; Jacqueline Capeau; Charles Coutelle; Marie Christiane Brahimi-Horn
Haemoglobin interferes with the ex vivo luciferase luminescence assay: consequence for detection of luciferase reporter gene expression in vivo.
Gene therapy 2000;7(15):1333-6.
2000: Stuart J Forbes; Michael Themis; Stuart McDonald; A Shiota; T Kobayashi; Charles Coutelle; Humphrey Hodgson
Tri-iodothyronine and a deleted form of hepatocyte growth factor act synergistically to enhance liver proliferation and enable in vivo retroviral gene transfer via the peripheral venous system.
Gene therapy 2000;7(9):784-9.
2000: Tristan McKay; Lesley MacVinish; B Carpenter; Michael Themis; Sarah Jezzard; R Goldin; A Pavirani; ME Hickman; Alan W Cuthbert; Charles Coutelle
Selective in vivo transfection of murine biliary epithelia using polycation-enhanced adenovirus.
Gene therapy 2000;7(8):644-52.
2000: Stuart J Forbes; Michael Themis; Stuart McDonald; I Sarosi; Charles Coutelle; Humphrey Hodgson
Synergistic growth factors enhance rat liver proliferation and enable retroviral gene transfer via a peripheral vein.
Gastroenterology 2000;118(3):591-8.
2000: Brian W Bigger; Oleg Tolmachov; JM Collombet; Charles Coutelle
Introduction of chloramphenicol resistance into the modified mouse mitochondrial genome: cloning of unstable sequences by passage through yeast.
Analytical biochemistry 2000;277(2):236-42.
2000: Morvane Colin; Michèle Maurice; Germain Trugnan; Michel Kornprobst; Richard P Harbottle; A Knight; RG Cooper; Andrew D Miller; Jacqueline Capeau; Charles Coutelle; Marie Christiane Brahimi-Horn
Cell delivery, intracellular trafficking and expression of an integrin-mediated gene transfer vector in tracheal epithelial cells.
Gene therapy 2000;7(2):139-52.
1999: Brian W Bigger; JM Collombet; Charles Coutelle
Tipping the scales in favour of mitochondrial gene therapy.
Gene therapy 1999;6(12):1909-10.
1999: Holm Schneider; S Adebakin; Michael Themis; Terry Cook; Anne-Marie Douar; A Pavirani; Charles Coutelle
Therapeutic plasma concentrations of human factor IX in mice after gene delivery into the amniotic cavity: a model for the prenatal treatment of haemophilia B.
The journal of gene medicine 1999;1(6):424-32.
1999: Holm Schneider; Richard P Harbottle; Yasuyuki Yokosaki; P Jost; Charles Coutelle
Targeted gene delivery into alpha9beta1-integrin-displaying cells by a synthetic peptide.
FEBS letters 1999;458(3):329-32.
1999: Michael Themis; Holm Schneider; T Kiserud; Terry Cook; S Adebakin; Sarah Jezzard; Stuart Forbes; M Hanson; A Pavirani; Charles Rodeck; Charles Coutelle
Successful expression of beta-galactosidase and factor IX transgenes in fetal and neonatal sheep after ultrasound-guided percutaneous adenovirus vector administration into the umbilical vein.
Gene therapy 1999;6(7):1239-48.
1999: Holm Schneider; Charles Coutelle
In utero gene therapy: the case for.
Nature medicine 1999;5(3):256-7.
1999: Andrew Knight; Jaime Carvajal; Holm Schneider; Charles Coutelle; Susan Chamberlain; Neil Fairweather
Non-viral neuronal gene delivery mediated by the HC fragment of tetanus toxin.
European journal of biochemistry / FEBS 1999;259(3):762-9.
1998: Morvane Colin; Richard P Harbottle; A Knight; Michel Kornprobst; RG Cooper; Andrew D Miller; Germain Trugnan; Jacqueline Capeau; Charles Coutelle; Marie Christiane Brahimi-Horn
Liposomes enhance delivery and expression of an RGD-oligolysine gene transfer vector in human tracheal cells.
Gene therapy 1998;5(11):1488-98.
1998: Michael Themis; Stuart J Forbes; L Chan; RG Cooper; CJ Etheridge; Andrew D Miller; Humphrey Hodgson; Charles Coutelle
Enhanced in vitro and in vivo gene delivery using cationic agent complexed retrovirus vectors.
Gene therapy 1998;5(9):1180-6.
1998: Holm Schneider; Richard P Harbottle; Yasuyuki Yokosaki; J Kunde; D Sheppard; Charles Coutelle
A novel peptide, PLAEIDGIELTY, for the targeting of alpha9beta1-integrins.
FEBS letters 1998;429(3):269-73.
1998: Richard P Harbottle; RG Cooper; Stephen Hart; A Ladhoff; Tristan McKay; A M Knight; Ernst Wagner; Andrew D Miller; Charles Coutelle
An RGD-oligolysine peptide: a prototype construct for integrin-mediated gene delivery.
Human gene therapy 1998;9(7):1037-47.
1998: Stuart J Forbes; Michael Themis; Stuart McDonald; Clare Selden; Charles Coutelle; Humphrey Hodgson
Retroviral gene transfer to the liver in vivo during tri-iodothyronine induced hyperplasia.
Gene therapy 1998;5(4):552-5.
1998: Stephen Hart; Carolina V Arancibia-Cárcamo; MA Wolfert; Carolina Mailhos; N J O'Reilly; Robin R Ali; Charles Coutelle; A J George; Richard P Harbottle; A M Knight; D F Larkin; Roland J Levinsky; L W Seymour; Adrian J Thrasher; Christine Kinnon
Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector.
Human gene therapy 1998;9(4):575-85.
1998: JM Collombet; Charles Coutelle
Towards gene therapy of mitochondrial disorders.
Molecular medicine today 1998;4(1):31-8.
1997: V C Wheeler; M Aitken; Charles Coutelle
Modification of the mouse mitochondrial genome by insertion of an exogenous gene.
Gene 1997;198(1-2):203-9.
1997: Anne-Marie Douar; S Adebakin; Michael Themis; A Pavirani; Terry Cook; Charles Coutelle
Foetal gene delivery in mice by intra-amniotic administration of retroviral producer cells and adenovirus.
Gene therapy 1997;4(9):883-90.
1997: Carol Shiels; Charles Coutelle; Clare Huxley
Contiguous arrays of satellites 1, 3, and beta form a 1.5-Mb domain on chromosome 22p.
Genomics 1997;44(1):35-44.
1997: E S Mayall; Charles Coutelle
RT-PCR method specific for the detection of transgenic CFTR mRNA in the presence of transgene plasmid DNA and endogenous CFTR mRNA.
Gene therapy 1997;4(8):875-8.
1997: F Behrens; U Claussen; L M Iyer; Eric Green; B Horsthemke; R Williamson; Clare Huxley; Charles Coutelle
Isolation of DNA from the centromere of human chromosome 7 by microdissection.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 1997;5(4):215-20.
1997: Ajay R Mistry; Luigi Falciola; Lucia Monaco; R Tagliabue; G Acerbis; A Knight; Richard P Harbottle; Marco Soria; Marco E Bianchi; Charles Coutelle; Stephen Hart
Recombinant HMG1 protein produced in Pichia pastoris: a nonviral gene delivery agent.
BioTechniques 1997;22(4):718-29.
1997: JM Collombet; V C Wheeler; F Vogel; Charles Coutelle
Introduction of plasmid DNA into isolated mitochondria by electroporation. A novel approach toward gene correction for mitochondrial disorders.
The Journal of biological chemistry 1997;272(8):5342-7.
1997: Carol Shiels; Charles Coutelle; Clare Huxley
Analysis of ribosomal and alphoid repetitive DNA by fiber-FISH.
Cytogenetics and cell genetics 1997;76(1-2):20-2.
1996: Antonio Villaverde; Jordi Feliu; Richard P Harbottle; A Benito; Charles Coutelle
A recombinant, arginine-glycine-aspartic acid (RGD) motif from foot-and-mouth disease virus binds mammalian cells through vitronectin and, to a lower extent, fibronectin receptors.
Gene 1996;180(1-2):101-6.
1996: Anne-Marie Douar; Michael Themis; Charles Coutelle
Fetal somatic gene therapy.
Molecular human reproduction 1996;2(9):633-41.
1996: Anne-Marie Douar; Michael Themis; V Sandig; T Friedmann; Charles Coutelle
Effect of amniotic fluid on cationic lipid mediated transfection and retroviral infection.
Gene therapy 1996;3(9):789-96.
1996: V C Wheeler; Chrisostomos Prodromou; Laurence H Pearl; R Williamson; Charles Coutelle
Synthesis of a modified gene encoding human ornithine transcarbamylase for expression in mammalian mitochondrial and universal translation systems: a novel approach towards correction of a genetic defect.
Gene 1996;169(2):251-5.
1995: Natasha J Caplen; E Kinrade; FL Sorgi; X Gao; Dieter C Gruenert; D Geddes; Charles Coutelle; L Huang; Eric W F W Alton; R Williamson
In vitro liposome-mediated DNA transfection of epithelial cell lines using the cationic liposome DC-Chol/DOPE.
Gene therapy 1995;2(9):603-13.
1995: Stephen Hart; Richard P Harbottle; R Cooper; A Miller; R Williamson; Charles Coutelle
Gene delivery and expression mediated by an integrin-binding peptide.
Gene therapy 1995;2(8):552-4.
1995: Stephen Hart; E Mayall; Myra Stern; F M Munkonge; A Frost; L Huang; M Vasilliou; R Williamson; Eric W F W Alton; Charles Coutelle
The introduction of two silent mutations into a CFTR cDNA construct allows improved detection of exogenous mRNA in gene transfer experiments.
Human molecular genetics 1995;4(9):1597-602.
1995: Charles Coutelle; Anne-Marie Douar; W H Colledge; Ursula G Froster
The challenge of fetal gene therapy.
Nature medicine 1995;1(9):864-6.
1995: V C Wheeler; Charles Coutelle
Nondegradative in vitro labeling of plasmid DNA.
Analytical biochemistry 1995;225(2):374-6.
1995: Natasha J Caplen; Eric W F W Alton; Peter G Middleton; Julia R Dorin; B J Stevenson; X Gao; S R Durham; Peter K Jeffery; M E Hodson; Charles Coutelle
Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis.
Nature medicine 1995;1(1):39-46.
1994: K Grade; Ingrid Grunewald; I Graupner; F Behrens; Charles Coutelle
Identification of three novel mutations in the CFTR gene using temperature-optimized non-radioactive conditions for SSCP analysis.
Human genetics 1994;94(2):154-8.
1994: U Jung; U Urner; K Grade; Charles Coutelle
Acceptability of carrier screening for cystic fibrosis during pregnancy in a German population.
Human genetics 1994;94(1):19-24.
1994: Stephen Hart; A M Knight; Richard P Harbottle; A Mistry; H D Hunger; D F Cutler; R Williamson; Charles Coutelle
Cell binding and internalization by filamentous phage displaying a cyclic Arg-Gly-Asp-containing peptide.
The Journal of biological chemistry 1994;269(17):12468-74.
1993: Charles Coutelle; Natasha J Caplen; S Hart; Clare Huxley; R Williamson
Gene therapy for cystic fibrosis.
Archives of disease in childhood 1993;68(4):437-40.
1992: Charles Coutelle; R Brückner; K Grade; F Behrens; J Gedschold; J Hein; Reinhard Szibor; I Bauer; J Brock; I Graupner
Prevalence of cystic fibrosis mutations in the East German population.
Human mutation 1992;1(2):109-12.
1992: Charles Coutelle; K Grade
[Molecular biological analysis of cystic fibrosis--a model example for the strategy of "reverse genetics"].
Pädiatrie und Grenzgebiete 1992;31(2):73-95.
1991: Charles Coutelle; K Grade; R Brückner; Reinhard Szibor; K Will; I Bauer; H Gorki; J Gedschold; J Brock; U Urner
CF DNA-diagnosis and gene mutation analysis: data from East Germany.
Pathologie-biologie 1991;39(6):585-6.
1991: C Gille; K Grade; Charles Coutelle
A pooling strategy for heterozygote screening of the delta F508 cystic fibrosis mutation.
Human genetics 1991;86(3):289-91.
1991: Charles Coutelle; K Grade; Astrid Speer; K Will; C Gille; Reinhard Szibor; J Gedschold; R Brückner; V Steinbicker; I Bauer
Present state of DNA-diagnosis for cystic fibrosis and attitudes concerning a heterozygote screening in the GDR.
Advances in experimental medicine and biology 1991;290():75-8; discussion 78-81.
1990: Astrid Speer; U Kräft; R Hanke; K Grade; Charles Coutelle; Karin Wulff; M Wehnert; Falko H Herrmann; L Kadasi; E Kunert
Deletion analysis of DMD/BMD families from the German Democratic Republic and selected regions of Czechoslovakia and Hungary.
Journal of medical genetics 1990;27(11):679-82.
1990: H D Hunger; C Flachmeier; G Schmidt; G Behrendt; Charles Coutelle
Ultrasensitive enzymatic radioimmunoassay using a fusion protein of protein A and neomycin phosphotransferase II in two-chamber-well microtiter plates.
Analytical biochemistry 1990;187(1):89-93.
1990: H D Hunger; G Schmidt; C Flachmeier; G Behrendt; Charles Coutelle
High-sensitivity protein detection by a new "contact-copy" method using a protein A-neomycin phosphotransferase II fusion protein.
Analytical biochemistry 1990;186(1):159-64.
1990: Astrid Speer; H Billwitz; A Huth; R Hanke; Charles Coutelle; S England; D Love; Kay E Davies
Mapping and sequencing in two intron regions of the human dystrophin gene.
Biomedica biochimica acta 1990;49(4):K1-2.
1989: A Huth; X Estivill; K Grade; H Billwitz; Astrid Speer; A Rosenthal; R Williamson; M Ramsay; Charles Coutelle
Polymerase chain reaction for detection of the pMP6d-9/MspI RFLP, a marker closely linked to the cystic fibrosis mutation.
Nucleic acids research 1989;17(17):7118.
1989: Olaf Riess; A Michel; W Berger; Peter Nürnberg; J T Epplen; Astrid Speer; Charles Coutelle
RFLP-discordance within the human phenylalanine hydroxylase locus.
Human genetics 1989;83(2):199-201.
1989: Astrid Speer; A Rosenthal; H Billwitz; R Hanke; S M Forrest; D Love; Kay E Davies; Charles Coutelle
DNA amplification of a further exon of Duchenne muscular dystrophy locus increase possibilities for deletion screening.
Nucleic acids research 1989;17(12):4892.
1989: D Merkel; G Schmidt; C Flachmeier; G Behrendt; Charles Coutelle; H D Hunger
A new neomycin phosphotransferase II solid phase assay in combination with polyacrylamide sodium dodecylsulphate gel electrophoresis.
Journal of biochemical and biophysical methods 1989;18(4):277-85.
1989: Charles Coutelle; A Speer; K Grade; A Rosenthal; H D Hunger
[The development of molecular human genetics and its significance for perspectives of modern medicine].
Pädiatrie und Grenzgebiete 1989;28(6):319-46.
1988: H D Hunger; C Flachmeier; G Schmidt; G Behrendt; Charles Coutelle
A protein-free blocking system for the covalently binding matrix cyanuric chloride-activated paper in immunological procedures.
Journal of biochemical and biophysical methods 1988;17(1):43-50.
1988: Olaf Riess; A Michel; Astrid Speer; W Meiske; G Cobet; Charles Coutelle
Linkage disequilibrium between RFLP haplotype 2 and the affected PAH allele in PKU families from the Berlin area of the German Democratic Republic.
Human genetics 1988;78(4):343-6.
1987: Olaf Riess; A Michel; Astrid Speer; G Cobet; Charles Coutelle
Introduction of genomic diagnosis of classical phenylketonuria to the health care system of the German Democratic Republic.
Clinical genetics 1987;32(4):209-15.
1987: W Berger; J Hein; J Gedschold; I Bauer; Astrid Speer; M Farrall; R Williamson; Charles Coutelle
Crossovers in two German cystic fibrosis families determine probe order for MET, 7C22 and XV-2c/CS.7.
Human genetics 1987;77(2):197-9.
1987: H D Hunger; Astrid Speer; C Flachmeier; R Hanke; G Behrendt; Charles Coutelle
Use of cyanuric chloride-activated paper for detection of subpicogram quantities of specific DNA sequences and its application to linked restriction fragment length polymorphism analysis in a Duchenne muscular dystrophy affected family.
Analytical biochemistry 1987;165(1):45-55.
1987: H J Dietzsch; Charles Coutelle; J Hein
[Possibilities and limits of gene technology diagnosis of cystic fibrosis].
Kinderärztliche Praxis 1987;55(6):279-82.
1986: Astrid Speer; R Bollman; A Michel; R Neumann; C Bommer; R Hanke; Olaf Riess; G Cobet; Charles Coutelle
Prenatal diagnosis of classical phenylketonuria by linked restriction fragment length polymorphism analysis.
Prenatal diagnosis 1986;6(6):447-50.
1986: H D Hunger; Charles Coutelle; G Behrendt; C Flachmeier; A Rosenthal; Astrid Speer; H Breter; R Szargan; P Franke; J Stahl
CCA paper: a new two-dimensional cyanuric chloride-activated matrix for universal application in molecular biology.
Analytical biochemistry 1986;156(2):286-99.
1986: Astrid Speer; H H Dahl; Olaf Riess; G Cobet; R Hanke; R G Cotton; Charles Coutelle
Typing of families with classical phenylketonuria using three alleles of the Hindiii linked restriction fragment polymorphism, detectable with a phenylalanine hydroxylase cDNA probe. Family typing for PKU by linked HindIII RFLP.
Clinical genetics 1986;29(6):491-5.
1986: Astrid Speer; K Davies; S McGlade; R Hanke; A W Spiegler; Reinhard Szibor; D Sommer; F Herrmann; Charles Coutelle
Possibilities and problems in genomic diagnosis of Duchenne muscular dystrophy with molecular probes.
Biomedica biochimica acta 1986;45(7):K19-27.