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Patrick Couvreur

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Bildstein L; Hillaireau H; Desmaële D; Lepêtre-Mouelhi S; Dubernet C; Couvreur P
Freeze-drying of squalenoylated nucleoside analogue nanoparticles.
Arias José L; Reddy L Harivardhan; Couvreur Patrick
Polymeric nanoparticulate system augmented the anticancer therapeutic efficacy of gemcitabine.
Othman Mohammad; Bouchemal Kawthar; Couvreur Patrick; Gref Ruxandra
Microcalorimetric investigation on the formation of supramolecular nanoassemblies of associative polymers loaded with gadolinium chelate derivatives.

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All Publications

2009: Bildstein L; Hillaireau H; Desmaële D; Lepêtre-Mouelhi S; Dubernet C; Couvreur P
Freeze-drying of squalenoylated nucleoside analogue nanoparticles.
International journal of pharmaceutics 2009;381(2):140-5.
2009: Arias José L; Reddy L Harivardhan; Couvreur Patrick
Polymeric nanoparticulate system augmented the anticancer therapeutic efficacy of gemcitabine.
Journal of drug targeting 2009;17(8):586-98.
2009: Othman Mohammad; Bouchemal Kawthar; Couvreur Patrick; Gref Ruxandra
Microcalorimetric investigation on the formation of supramolecular nanoassemblies of associative polymers loaded with gadolinium chelate derivatives.
International journal of pharmaceutics 2009;379(2):218-25.
2009: Hillaireau Hervé; Couvreur Patrick
Nanocarriers' entry into the cell: relevance to drug delivery.
Cellular and molecular life sciences : CMLS 2009;66(17):2873-96.
2009: Angelov Borislav; Angelova Angelina; Vainio Ulla; Garamus Vasil M; Lesieur Sylviane; Willumeit Regine; Couvreur Patrick
Long-living intermediates during a lamellar to a diamond-cubic lipid phase transition: a small-angle X-ray scattering investigation.
Langmuir : the ACS journal of surfaces and colloids 2009;25(6):3734-42.
2009: de Martimprey H; Vauthier C; Malvy C; Couvreur P
Polymer nanocarriers for the delivery of small fragments of nucleic acids: oligonucleotides and siRNA.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2009;71(3):490-504.
2008: Bouclier Céline; Moine Laurence; Hillaireau Hervé; Marsaud Véronique; Connault Elisabeth; Opolon Paule; Couvreur Patrick; Fattal Elias; Renoir Jack-Michel
Physicochemical characteristics and preliminary in vivo biological evaluation of nanocapsules loaded with siRNA targeting estrogen receptor alpha.
Biomacromolecules 2008;9(10):2881-90.
2008: Reddy L Harivardhan; Khoury Hania; Paci Angelo; Deroussent Alain; Ferreira Humberto; Dubernet Catherine; Declèves Xavier; Besnard Madeleine; Chacun Helène; Lepêtre-Mouelhi Sinda; Desmaële Didier; Rousseau Bernard; Laugier Christelle; Cintrat Jean-Christophe; Vassal Gilles; Couvreur Patrick
Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(8):1570-7.
2008: Arias José L; Reddy L Harivardhan; Couvreur Patrick
Magnetoresponsive squalenoyl gemcitabine composite nanoparticles for cancer active targeting.
Langmuir : the ACS journal of surfaces and colloids 2008;24(14):7512-9.
2008: Chemin Caroline; Bourgaux Claudie; Péan Jean-Manuel; Pabst Georg; Wüthrich Patrick; Couvreur Patrick; Ollivon Michel
Consequences of ions and pH on the supramolecular organization of sphingomyelin and sphingomyelin/cholesterol bilayers.
Chemistry and physics of lipids 2008;153(2):119-29.
2008: Reddy L Harivardhan; Marque Pierre-Emmanuel; Dubernet Catherine; Mouelhi Sinda-Lepêtre; Desmaële Didier; Couvreur Patrick
Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine.
The Journal of pharmacology and experimental therapeutics 2008;325(2):484-90.
2008: Breton Pascal; Larras Virginie; Roy Didier; Sagodira Serge; Limal David; Bonnafous David; Colin Nathalie; Bru Nicole; Fattal Elias; Couvreur Patrick
Biocompatible poly(methylidene malonate)-made materials for pharmaceutical and biomedical applications.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;68(3):479-95.
2008: Couvreur Patrick; Reddy L Harivardhan; Mangenot Stéphanie; Poupaert Jacques H; Desmaële Didier; Lepêtre-Mouelhi Sinda; Pili Barbara; Bourgaux Claudie; Amenitsch H; Ollivon Michel
Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue.
Small (Weinheim an der Bergstrasse, Germany) 2008;4(2):247-53.
2008: de Martimprey Henri; Bertrand Jean-Remi; Fusco Alfredo; Santoro Massimo; Couvreur Patrick; Vauthier Christine; Malvy Claude
siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma.
Nucleic acids research 2008;36(1):e2.
2008: Reddy L Harivardhan; Couvreur Patrick
Novel approaches to deliver gemcitabine to cancers.
Current pharmaceutical design 2008;14(11):1124-37.
2007: Bouligand Jerome; Couvreur Patrick; Layre Anne M; Deroussent Alain; Paci Angelo; Delain Etienne; Vassal Gilles; Gref Ruxandra
Busulphan-loaded long-circulating nanospheres, a very attractive challenge for both galenists and pharmacologists.
Journal of microencapsulation 2007;24(8):715-30.
2007: Reddy L Harivardhan; Dubernet Catherine; Mouelhi Sinda Lepetre; Marque Pierre Emmanuel; Desmaele Didier; Couvreur Patrick
A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types.
Journal of controlled release : official journal of the Controlled Release Society 2007;124(1-2):20-7.
2007: Angelov Borislav; Angelova Angelina; Garamus Vasil M; Lebas Geneviève; Lesieur Sylviane; Ollivon Michel; Funari Sérgio S; Willumeit Regine; Couvreur Patrick
Small-angle neutron and X-ray scattering from amphiphilic stimuli-responsive diamond-type bicontinuous cubic phase.
Journal of the American Chemical Society 2007;129(44):13474-9.
2007: Stella Barbara; Arpicco Silvia; Rocco Flavio; Marsaud Véronique; Renoir Jack-Michel; Cattel Luigi; Couvreur Patrick
Encapsulation of gemcitabine lipophilic derivatives into polycyanoacrylate nanospheres and nanocapsules.
International journal of pharmaceutics 2007;344(1-2):71-7.
2007: Lalanne M; Andrieux K; Paci A; Besnard M; Ré M; Bourgaux C; Ollivon M; Desmaele D; Couvreur P
Liposomal formulation of a glycerolipidic prodrug for lymphatic delivery of didanosine via oral route.
International journal of pharmaceutics 2007;344(1-2):62-70.
2007: Khoury Hania; Deroussent Alain; Reddy L Harivardhan; Couvreur Patrick; Vassal Gilles; Paci Angelo
Simultaneous determination of gemcitabine and gemcitabine-squalene by liquid chromatography-tandem mass spectrometry in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;858(1-2):71-8.
2007: Kim Hyun Ryoung; Andrieux Karine; Delomenie Claudine; Chacun Héléne; Appel Martine; Desmaële Didier; Taran Fréderic; Georgin Dominique; Couvreur Patrick; Taverna Myriam
Analysis of plasma protein adsorption onto PEGylated nanoparticles by complementary methods: 2-DE, CE and Protein Lab-on-chip system.
Electrophoresis 2007;28(13):2252-61.
2007: Chauvierre Cédric; Leclerc Liliane; Labarre Denis; Appel Martine; Marden Michael C; Couvreur Patrick; Vauthier Christine
Enhancing the tolerance of poly(isobutylcyanoacrylate) nanoparticles with a modular surface design.
International journal of pharmaceutics 2007;338(1-2):327-32.
2007: Lalanne Muriel; Paci Angelo; Andrieux Karine; Dereuddre-Bosquet Nathalie; Clayette Pascal; Deroussent Alain; Ré Micheline; Vassal Gilles; Couvreur Patrick; Desmaële Didier
Synthesis and biological evaluation of two glycerolipidic prodrugs of didanosine for direct lymphatic delivery against HIV.
Bioorganic & medicinal chemistry letters 2007;17(8):2237-40.
2007: Kim Hyun R; Andrieux Karine; Gil Sophie; Taverna Myriam; Chacun Héléne; Desmaële Didier; Taran Fréderic; Georgin Dominique; Couvreur Patrick
Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells: role of apolipoproteins in receptor-mediated endocytosis.
Biomacromolecules 2007;8(3):793-9.
2007: Hillaireau H; Le Doan T; Chacun H; Janin J; Couvreur P
Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers.
International journal of pharmaceutics 2007;331(2):148-52.
2007: Daoud-Mahammed S; Ringard-Lefebvre C; Razzouq N; Rosilio V; Gillet B; Couvreur P; Amiel C; Gref R
Spontaneous association of hydrophobized dextran and poly-beta-cyclodextrin into nanoassemblies. Formation and interaction with a hydrophobic drug.
Journal of colloid and interface science 2007;307(1):83-93.
2007: Daoud-Mahammed S; Couvreur P; Gref R
Novel self-assembling nanogels: stability and lyophilisation studies.
International journal of pharmaceutics 2007;332(1-2):185-91.
2007: Stella Barbara; Marsaud Véronique; Arpicco Silvia; Géraud Gérard; Cattel Luigi; Couvreur Patrick; Renoir Jack-Michel
Biological characterization of folic acid-conjugated poly(H2NPEGCA-co-HDCA) nanoparticles in cellular models.
Journal of drug targeting 2007;15(2):146-53.
2007: Kim H Ryoung; Gil S; Andrieux K; Nicolas V; Appel M; Chacun H; Desmaële D; Taran F; Georgin D; Couvreur P
Low-density lipoprotein receptor-mediated endocytosis of PEGylated nanoparticles in rat brain endothelial cells.
Cellular and molecular life sciences : CMLS 2007;64(3):356-64.
2006: Hillaireau Hervé; Le Doan Trung; Appel Martine; Couvreur Patrick
Hybrid polymer nanocapsules enhance in vitro delivery of azidothymidine-triphosphate to macrophages.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(3):346-52.
2006: Couvreur Patrick; Stella Barbara; Reddy L Harivardhan; Hillaireau Hervé; Dubernet Catherine; Desmaële Didier; Lepêtre-Mouelhi Sinda; Rocco Flavio; Dereuddre-Bosquet Nathalie; Clayette Pascal; Rosilio Véronique; Marsaud Véronique; Renoir Jack-Michel; Cattel Luigi
Squalenoyl nanomedicines as potential therapeutics.
Nano letters 2006;6(11):2544-8.
2006: Toub N; Malvy C; Fattal E; Couvreur P
Innovative nanotechnologies for the delivery of oligonucleotides and siRNA.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2006;60(9):607-20.
2006: Layre Anne-Magali; Couvreur Patrick; Chacun Hélène; Aymes-Chodur Caroline; Ghermani Nour-Eddine; Poupaert Jacques; Richard Joël; Requier Denis; Gref Ruxandra
Busulfan loading into poly(alkyl cyanoacrylate) nanoparticles: physico-chemistry and molecular modeling.
Journal of biomedical materials research. Part B, Applied biomaterials 2006;79(2):254-62.
2006: Hillaireau H; Le Doan T; Besnard M; Chacun H; Janin J; Couvreur P
Encapsulation of antiviral nucleotide analogues azidothymidine-triphosphate and cidofovir in poly(iso-butylcyanoacrylate) nanocapsules.
International journal of pharmaceutics 2006;324(1):37-42.
2006: Bertholon Isabelle; Ponchel Gilles; Labarre Denis; Couvreur Patrick; Vauthier Christine
Bioadhesive properties of poly(alkylcyanoacrylate) nanoparticles coated with polysaccharide.
Journal of nanoscience and nanotechnology 2006;6(9-10):3102-9.
2006: Hillaireau Hervé; Le Doan Trung; Couvreur Patrick
Polymer-based nanoparticles for the delivery of nucleoside analogues.
Journal of nanoscience and nanotechnology 2006;6(9-10):2608-17.
2006: Layre A-M; Couvreur P; Richard J; Requier D; Eddine Ghermani N; Gref R
Freeze-drying of composite core-shell nanoparticles.
Drug development and industrial pharmacy 2006;32(7):839-46.
2006: Couvreur Patrick; Vauthier Christine
Nanotechnology: intelligent design to treat complex disease.
Pharmaceutical research 2006;23(7):1417-50.
2006: Toub Nedjma; Bertrand Jean-Rémi; Tamaddon Ali; Elhamess Hind; Hillaireau Hervé; Maksimenko Andrei; Maccario Jean; Malvy Claude; Fattal Elias; Couvreur Patrick
Efficacy of siRNA nanocapsules targeted against the EWS-Fli1 oncogene in Ewing sarcoma.
Pharmaceutical research 2006;23(5):892-900.
2006: Angelov Borislav; Angelova Angelina; Papahadjopoulos-Sternberg Brigitte; Lesieur Sylviane; Sadoc Jean-François; Ollivon Michel; Couvreur Patrick
Detailed structure of diamond-type lipid cubic nanoparticles.
Journal of the American Chemical Society 2006;128(17):5813-7.
2006: Gref Ruxandra; Amiel Catherine; Molinard Karine; Daoud-Mahammed Samia; Sébille Bernard; Gillet Brigitte; Beloeil Jean-Claude; Ringard Catherine; Rosilio Véronique; Poupaert Jaques; Couvreur Patrick
New self-assembled nanogels based on host-guest interactions: characterization and drug loading.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(3):316-24.
2006: Layre A; Couvreur P; Chacun H; Richard J; Passirani C; Requier D; Benoit J P; Gref R
Novel composite core-shell nanoparticles as busulfan carriers.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(3):271-80.
2006: Désiré Laurent; Mysiakine Evgueni; Bonnafous David; Couvreur Patrick; Sagodira Serge; Breton Pascal; Fattal Elias
Sustained delivery of growth factors from methylidene malonate 2.1.2-based polymers.
Biomaterials 2006;27(12):2609-20.
2006: Lemarchand Caroline; Gref Ruxandra; Passirani Catherine; Garcion Emmanuel; Petri Boris; Müller Rainer; Costantini Dominique; Couvreur Patrick
Influence of polysaccharide coating on the interactions of nanoparticles with biological systems.
Biomaterials 2006;27(1):108-18.
2006: Toub Nedjma; Bertrand Jean-Rémi; Malvy Claude; Fattal Elias; Couvreur Patrick
Antisense oligonucleotide nanocapsules efficiently inhibit EWS-Fli1 expression in a Ewing's sarcoma model.
Oligonucleotides 2006;16(2):158-68.
2005: Maksimenko Andrei; Polard Valerie; Villemeur Marie; Elhamess Hind; Couvreur Patrick; Bertrand Jean-Remi; Aboubakar Malam; Gottikh Marina; Malvy Claude
In vivo potentialities of EWS-Fli-1 targeted antisense oligonucleotides-nanospheres complexes.
Annals of the New York Academy of Sciences 2005;1058():52-61.
2005: Lemarchand Caroline; Gref Ruxandra; Lesieur Sylviane; Hommel Hubert; Vacher Béatrice; Besheer Ahmed; Maeder Karsten; Couvreur Patrick
Physico-chemical characterization of polysaccharide-coated nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society 2005;108(1):97-111.
2005: Rabinovich-Guilatt Laura; Dubernet Catherine; Gaudin Karen; Lambert Gregory; Couvreur Patrick; Chaminade Pierre
Phospholipid hydrolysis in a pharmaceutical emulsion assessed by physicochemical parameters and a new analytical method.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2005;61(1-2):69-76.
2005: Toub Nedjma; Angiari Chiara; Eboué Dominique; Fattal Elias; Tenu Jean-Pierre; Le Doan Trung; Couvreur Patrick
Cellular fate of oligonucleotides when delivered by nanocapsules of poly(isobutylcyanoacrylate).
Journal of controlled release : official journal of the Controlled Release Society 2005;106(1-2):209-13.
2005: Maignien Thomas; Shakweh Monjed; Calvo Pilar; Marcé Dominique; Salès Nicole; Fattal Elias; Deslys Jean-Philippe; Couvreur Patrick; Lasmezas Corinne Ida
Role of gut macrophages in mice orally contaminated with scrapie or BSE.
International journal of pharmaceutics 2005;298(2):293-304.
2005: Garcia-Garcia Elizabeth; Andrieux Karine; Gil Sophie; Kim Hyun Ryoung; Le Doan Trung; Desmaële Didier; d'Angelo Jean; Taran Frédéric; Georgin Dominique; Couvreur Patrick
A methodology to study intracellular distribution of nanoparticles in brain endothelial cells.
International journal of pharmaceutics 2005;298(2):310-4.
2005: Layre Anne-Magali; Gref Ruxandra; Richard Joël; Requier Denis; Chacun Hélène; Appel Martine; Domb Abraham J; Couvreur Patrick
Nanoencapsulation of a crystalline drug.
International journal of pharmaceutics 2005;298(2):323-7.
2005: Garcia-Garcia E; Andrieux K; Gil S; Couvreur P
Colloidal carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain?
International journal of pharmaceutics 2005;298(2):274-92.
2005: Garcia-Garcia E; Gil S; Andrieux K; Desmaële D; Nicolas V; Taran F; Georgin D; Andreux J P; Roux F; Couvreur P
A relevant in vitro rat model for the evaluation of blood-brain barrier translocation of nanoparticles.
Cellular and molecular life sciences : CMLS 2005;62(12):1400-8.
2005: Angelova Angelina; Angelov Borislav; Papahadjopoulos-Sternberg Brigitte; Bourgaux Claudie; Couvreur Patrick
Protein driven patterning of self-assembled cubosomic nanostructures: long oriented nanoridges.
The journal of physical chemistry. B 2005;109(8):3089-93.
2004: de Kozak Yvonne; Andrieux Karine; Villarroya Henri; Klein Christophe; Thillaye-Goldenberg Brigitte; Naud Marie-Christine; Garcia Elisabeth; Couvreur Patrick
Intraocular injection of tamoxifen-loaded nanoparticles: a new treatment of experimental autoimmune uveoretinitis.
European journal of immunology 2004;34(12):3702-12.
2004: Brigger Irène; Morizet Jackie; Laudani Lysiane; Aubert Geneviève; Appel Martine; Velasco Valérie; Terrier-Lacombe Marie-Josée; Desmaële Didier; d'Angelo Jean; Couvreur Patrick; Vassal Gilles
Negative preclinical results with stealth nanospheres-encapsulated Doxorubicin in an orthotopic murine brain tumor model.
Journal of controlled release : official journal of the Controlled Release Society 2004;100(1):29-40.
2004: Lemarchand Caroline; Gref Ruxandra; Couvreur Patrick
Polysaccharide-decorated nanoparticles.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2004;58(2):327-41.
2004: Rabinovich-Guilatt Laura; Couvreur Patrick; Lambert Gregory; Goldstein Danny; Benita Simon; Dubernet Catherine
Extensive surface studies help to analyse zeta potential data: the case of cationic emulsions.
Chemistry and physics of lipids 2004;131(1):1-13.
2004: Chauvierre Cedric; Marden M C Michael C; Vauthier Christine; Labarre Denis; Couvreur Patrick; Leclerc Liliane
Heparin coated poly(alkylcyanoacrylate) nanoparticles coupled to hemoglobin: a new oxygen carrier.
Biomaterials 2004;25(15):3081-6.
2004: Chauvierre C; Vauthier C; Labarre D; Couvreur P; Marden M C; Leclerc L
A new generation of polymer nanoparticles for drug delivery.
Cellular and molecular biology (Noisy-le-Grand, France) 2004;50(3):233-9.
2004: Ghermani Nour Eddine; Spasojevic-de Biré Anne; Bouhmaida Nouzha; Ouharzoune Souad; Bouligand Jérôme; Layre Anne; Gref Ruxandra; Couvreur Patrick
Molecular reactivity of busulfan through its experimental electrostatic properties in the solid state.
Pharmaceutical research 2004;21(4):598-607.
2004: Fattal Elias; Couvreur Patrick; Dubernet Catherine
"Smart" delivery of antisense oligonucleotides by anionic pH-sensitive liposomes.
Advanced drug delivery reviews 2004;56(7):931-46.
2004: Rabinovich-Guilatt Laura; Couvreur Patrick; Lambert Gregory; Dubernet Catherine
Cationic vectors in ocular drug delivery.
Journal of drug targeting 2004;12(9-10):623-33.
2003: Maksimenko A; Lambert G; Bertrand J R; Fattal E; Couvreur P; Malvy C
Therapeutic potentialities of EWS-Fli-1 mRNA-targeted vectorized antisense oligonucleotides.
Annals of the New York Academy of Sciences 2003;1002():72-7.
2003: Vauthier C; Dubernet C; Chauvierre C; Brigger I; Couvreur P
Drug delivery to resistant tumors: the potential of poly(alkyl cyanoacrylate) nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society 2003;93(2):151-60.
2003: Chauvierre Cédric; Labarre Denis; Couvreur Patrick; Vauthier Christine
Novel polysaccharide-decorated poly(isobutyl cyanoacrylate) nanoparticles.
Pharmaceutical research 2003;20(11):1786-93.
2003: Gref Ruxandra; Couvreur Patrick; Barratt Gillian; Mysiakine Evgueni
Surface-engineered nanoparticles for multiple ligand coupling.
Biomaterials 2003;24(24):4529-37.
2003: Maksimenko Andrei; Malvy Claude; Lambert Gregory; Bertrand Jean-Rémy; Fattal Elias; Maccario Jean; Couvreur Patrick
Oligonucleotides targeted against a junction oncogene are made efficient by nanotechnologies.
Pharmaceutical research 2003;20(10):1565-7.
2003: Lemarchand Caroline; Couvreur Patrick; Besnard Madeleine; Costantini Dominique; Gref Ruxandra
Novel polyester-polysaccharide nanoparticles.
Pharmaceutical research 2003;20(8):1284-92.
2003: Pinto-Alphandary Huguette; Aboubakar Malam; Jaillard Danielle; Couvreur Patrick; Vauthier Christine
Visualization of insulin-loaded nanocapsules: in vitro and in vivo studies after oral administration to rats.
Pharmaceutical research 2003;20(7):1071-84.
2003: Teixeira H; Dubernet C; Chacun H; Rabinovich L; Boutet V; Deverre J R; Benita S; Couvreur P
Cationic emulsions improves the delivery of oligonucleotides to leukemic P388/ADR cells in ascite.
Journal of controlled release : official journal of the Controlled Release Society 2003;89(3):473-82.
2003: Brigger Irène; Armand-Lefevre Laurence; Chaminade Pierre; Besnard Madeleine; Rigaldie Yohan; Largeteau Alain; Andremont Antoine; Grislain Luc; Demazeau Gérard; Couvreur Patrick
The stenlying effect of high hydrostatic pressure on thermally and hydrolytically labile nanosized carriers.
Pharmaceutical research 2003;20(4):674-83.
2003: Vauthier Christine; Dubernet Catherine; Fattal Elias; Pinto-Alphandary Huguette; Couvreur Patrick
Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications.
Advanced drug delivery reviews 2003;55(4):519-48.
2003: Lemarchand Caroline; Couvreur Patrick; Vauthier Christine; Costantini Dominique; Gref Ruxandra
Study of emulsion stabilization by graft copolymers using the optical analyzer Turbiscan.
International journal of pharmaceutics 2003;254(1):77-82.
2002: Brigger Irène; Morizet Jackie; Aubert Geneviève; Chacun Hélène; Terrier-Lacombe Marie-José; Couvreur Patrick; Vassal Gilles
Poly(ethylene glycol)-coated hexadecylcyanoacrylate nanospheres display a combined effect for brain tumor targeting.
The Journal of pharmacology and experimental therapeutics 2002;303(3):928-36.
2002: Brigger Irène; Dubernet Catherine; Couvreur Patrick
Nanoparticles in cancer therapy and diagnosis.
Advanced drug delivery reviews 2002;54(5):631-51.
2002: Fattal Elias; Pecquet Sophie; Couvreur Patrick; Andremont Antoine
Biodegradable microparticles for the mucosal delivery of antibacterial and dietary antigens.
International journal of pharmaceutics 2002;242(1-2):15-24.
2002: Calvo Pilar; Gouritin Bruno; Villarroya Henri; Eclancher Françoise; Giannavola Claudia; Klein Christophe; Andreux Jean P; Couvreur Patrick
Quantification and localization of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during experimental allergic encephalomyelitis in the rat.
The European journal of neuroscience 2002;15(8):1317-26.
2002: Beringue Vincent; Couvreur Patrick; Dormont Dominique
Involvement of macrophages in the pathogenesis of transmissible spongiform encephalopathies.
Developmental immunology 2002;9(1):19-27.
2002: Fattal E; Couvreur P; Pecquet S
[Oral tolerance induced by poly (lactide-co-glycolide) containing B lactoglobulin]
Annales pharmaceutiques françaises 2002;60(1):44-9.
2002: Bochot Amélie; Fattal Elias; Boutet Valérie; Deverre Jean Robert; Jeanny Jean Claude; Chacun Hélène; Couvreur Patrick
Intravitreal delivery of oligonucleotides by sterically stabilized liposomes.
Investigative ophthalmology & visual science 2002;43(1):253-9.
2001: Calvo P; Gouritin B; Brigger I; Lasmezas C; Deslys J; Williams A; Andreux J P; Dormont D; Couvreur P
PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases.
Journal of neuroscience methods 2001;111(2):151-5.
2001: Teixeira H; Rosilio V; Laigle A; Lepault J; Erk I; Scherman D; Benita S; Couvreur P; Dubernet C
Characterization of oligonucleotide/lipid interactions in submicron cationic emulsions: influence of the cationic lipid structure and the presence of PEG-lipids.
Biophysical chemistry 2001;92(3):169-81.
2001: Calvo P; Gouritin B; Chacun H; Desmaële D; D'Angelo J; Noel J P; Georgin D; Fattal E; Andreux J P; Couvreur P
Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery.
Pharmaceutical research 2001;18(8):1157-66.
2001: Le Visage C; Quaglia F; Dreux M; Ounnar S; Breton P; Bru N; Couvreur P; Fattal E
Novel microparticulate system made of poly(methylidene malonate 2.1.2).
Biomaterials 2001;22(16):2229-38.
2001: Le Visage C; Couvreur P; Mysiakine E; Breton P; Bru N; Fattal E
In vitro and in vivo evaluation of poly(methylidene malonate 2.1.2) microparticles behavior for oral administration.
Journal of drug targeting 2001;9(2):141-53.
2001: Lambert G; Fattal E; Couvreur P
Nanoparticulate systems for the delivery of antisense oligonucleotides.
Advanced drug delivery reviews 2001;47(1):99-112.
2001: Brigger I; Chaminade P; Marsaud V; Appel M; Besnard M; Gurny R; Renoir M; Couvreur P
Tamoxifen encapsulation within polyethylene glycol-coated nanospheres. A new antiestrogen formulation.
International journal of pharmaceutics 2001;214(1-2):37-42.
2001: Nicoli S; Santi P; Couvreur P; Couarraze G; Colombo P; Fattal E
Design of triptorelin loaded nanospheres for transdermal iontophoretic administration.
International journal of pharmaceutics 2001;214(1-2):31-5.
2001: Lambert G; Fattal E; Pinto-Alphandary H; Gulik A; Couvreur P
Polyisobutylcyanoacrylate nanocapsules containing an aqueous core for the delivery of oligonucleotides.
International journal of pharmaceutics 2001;214(1-2):13-6.
2001: Teixeira H; Dubernet C; Rosilio V; Laigle A; Deverre J R; Scherman D; Benita S; Couvreur P
Factors influencing the oligonucleotides release from O-W submicron cationic emulsions.
Journal of controlled release : official journal of the Controlled Release Society 2001;70(1-2):243-55.
2000: Lambert G; Bertrand J R; Fattal E; Subra F; Pinto-Alphandary H; Malvy C; Auclair C; Couvreur P
EWS fli-1 antisense nanocapsules inhibits ewing sarcoma-related tumor in mice.
Biochemical and biophysical research communications 2000;279(2):401-6.
2000: Stella B; Arpicco S; Peracchia M T; Desmaële D; Hoebeke J; Renoir M; D'Angelo J; Cattel L; Couvreur P
Design of folic acid-conjugated nanoparticles for drug targeting.
Journal of pharmaceutical sciences 2000;89(11):1452-64.
2000: Teixeira H; Dubernet C; Rosilio V; Benita S; Lepault J; Erk I; Couvreur P
New bicompartmental structures are observed when stearylamine is mixed with triglyceride emulsions.
Pharmaceutical research 2000;17(10):1329-32.
2000: de Oliveira M C; Rosilio V; Lesieur P; Bourgaux C; Couvreur P; Ollivon M; Dubernet C
pH-sensitive liposomes as a carrier for oligonucleotides: a physico-chemical study of the interaction between DOPE and a 15-mer oligonucleotide in excess water.
Biophysical chemistry 2000;87(2-3):127-37.
2000: Brigger I; Chaminade P; Desmaële D; Peracchia M T; d'Angelo J; Gurny R; Renoir M; Couvreur P
Near infrared with principal component analysis as a novel analytical approach for nanoparticle technology.
Pharmaceutical research 2000;17(9):1124-32.
2000: De Oliveira M C; Boutet V; Fattal E; Boquet D; Grognet J M; Couvreur P; Deverre J R
Improvement of in vivo stability of phosphodiester oligonucleotide using anionic liposomes in mice.
Life sciences 2000;67(13):1625-37.
2000: Trolle S; Chachaty E; Kassis-Chikhani N; Wang C; Fattal E; Couvreur P; Diamond B; Alonso J; Andremont A
Intranasal immunization with protein-linked phosphorylcholine protects mice against a lethal intranasal challenge with streptococcus pneumoniae.
Vaccine 2000;18(26):2991-8.
2000: Lambert G; Fattal E; Pinto-Alphandary H; Gulik A; Couvreur P
Polyisobutylcyanoacrylate nanocapsules containing an aqueous core as a novel colloidal carrier for the delivery of oligonucleotides.
Pharmaceutical research 2000;17(6):707-14.
2000: Beringue V; Demoy M; Lasmézas C I; Gouritin B; Weingarten C; Deslys J P; Andreux J P; Couvreur P; Dormont D
Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis.
The Journal of pathology 2000;190(4):495-502.
2000: Pecquet S; Leo E; Fritsché R; Pfeifer A; Couvreur P; Fattal E
Oral tolerance elicited in mice by beta-lactoglobulin entrapped in biodegradable microspheres.
Vaccine 2000;18(13):1196-202.
2000: Beringue V; Lamoury F; Adjou K T; Maignien T; Demoy M; Couvreur P; Dormont D
Pharmacological manipulation of early PrPres accumulation in the spleen of scrapie-infected mice.
Archives of virology. Supplementum 2000;(16):39-56.
1999: Aboubakar M; Puisieux F; Couvreur P; Deyme M; Vauthier C
Study of the mechanism of insulin encapsulation in poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization.
Journal of biomedical materials research 1999;47(4):568-76.
1999: Gibaud S; Weingarten C; Andreux J P; Couvreur P
[Targeting bone marrow with the help of polyalkylcyanoacrylate nanoparticles]
Annales pharmaceutiques françaises 1999;57(4):324-31.
1999: Peracchia M T; Harnisch S; Pinto-Alphandary H; Gulik A; Dedieu J C; Desmaële D; d'Angelo J; Müller R H; Couvreur P
Visualization of in vitro protein-rejecting properties of PEGylated stealth polycyanoacrylate nanoparticles.
Biomaterials 1999;20(14):1269-75.
1999: Peracchia M T; Fattal E; Desmaële D; Besnard M; Noël J P; Gomis J M; Appel M; d'Angelo J; Couvreur P
Stealth PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting.
Journal of controlled release : official journal of the Controlled Release Society 1999;60(1):121-8.
1999: Rojas J; Pinto-Alphandary H; Leo E; Pecquet S; Couvreur P; Fattal E
Optimization of the encapsulation and release of beta-lactoglobulin entrapped poly(DL-lactide-co-glycolide) microspheres.
International journal of pharmaceutics 1999;183(1):67-71.
1999: Aboubakar M; Puisieux F; Couvreur P; Vauthier C
Physico-chemical characterization of insulin-loaded poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization.
International journal of pharmaceutics 1999;183(1):63-6.
1999: Rojas J; Pinto-Alphandary H; Leo E; Pecquet S; Couvreur P; Gulik A; Fattal E
A polysorbate-based non-ionic surfactant can modulate loading and release of beta-lactoglobulin entrapped in multiphase poly(DL-lactide-co-glycolide) microspheres.
Pharmaceutical research 1999;16(2):255-60.
1999: Demoy M; Andreux J P; Weingarten C; Gouritin B; Guilloux V; Couvreur P
Spleen capture of nanoparticles: influence of animal species and surface characteristics.
Pharmaceutical research 1999;16(1):37-41.
1999: Teixeira H; Dubernet C; Puisieux F; Benita S; Couvreur P
Submicron cationic emulsions as a new delivery system for oligonucleotides.
Pharmaceutical research 1999;16(1):30-6.
1999: Demoy M; Andreux J P; Weingarten C; Gouritin B; Guilloux V; Couvreur P
In vitro evaluation of nanoparticles spleen capture.
Life sciences 1999;64(15):1329-37.
1998: Page-Clisson M E; Pinto-Alphandary H; Ourevitch M; Andremont A; Couvreur P
Development of ciprofloxacin-loaded nanoparticles: physicochemical study of the drug carrier.
Journal of controlled release : official journal of the Controlled Release Society 1998;56(1-3):23-32.
1998: Bochot A; Fattal E; Gulik A; Couarraze G; Couvreur P
Liposomes dispersed within a thermosensitive gel: a new dosage form for ocular delivery of oligonucleotides.
Pharmaceutical research 1998;15(9):1364-9.
1998: De Oliveira M C; Fattal E; Couvreur P; Lesieur P; Bourgaux C; Ollivon M; Dubernet C
pH-sensitive liposomes as a carrier for oligonucleotides: a physico-chemical study of the interaction between DOPE and a 15-mer oligonucleotide in quasi-anhydrous samples.
Biochimica et biophysica acta 1998;1372(2):301-10.
1998: Leo E; Pecquet S; Rojas J; Couvreur P; Fattal E
Changing the pH of the external aqueous phase may modulate protein entrapment and delivery from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent evaporation method.
Journal of microencapsulation 1998;15(4):421-30.
1998: Peracchia M T; Vauthier C; Desmaële D; Gulik A; Dedieu J C; Demoy M; d'Angelo J; Couvreur P
Pegylated nanoparticles from a novel methoxypolyethylene glycol cyanoacrylate-hexadecyl cyanoacrylate amphiphilic copolymer.
Pharmaceutical research 1998;15(4):550-6.
1998: Page-Clisson M E; Pinto-Alphandary H; Chachaty E; Couvreur P; Andremont A
Drug targeting by polyalkylcyanoacrylate nanoparticles is not efficient against persistent Salmonella.
Pharmaceutical research 1998;15(4):544-9.
1998: Allaoui-Attarki K; Fattal E; Pecquet S; Trollé S; Chachaty E; Couvreur P; Andremont A
Mucosal immunogenicity elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly (D,L-lactide-co-glycolide) microspheres.
Vaccine 1998;16(7):685-91.
1998: Gibaud S; Rousseau C; Weingarten C; Favier R; Douay L; Andreux J P; Couvreur P
Polyalkylcyanoacrylate nanoparticles as carriers for granulocyte-colony stimulating factor (G-CSF).
Journal of controlled release : official journal of the Controlled Release Society 1998;52(1-2):131-9.
1998: Bochot A; Mashhour B; Puisieux F; Couvreur P; Fattal E
Comparison of the ocular distribution of a model oligonucleotide after topical instillation in rabbits of conventional and new dosage forms.
Journal of drug targeting 1998;6(4):309-13.
1997: Demoy M; Gibaud S; Andreux J P; Weingarten C; Gouritin B; Couvreur P
Splenic trapping of nanoparticles: complementary approaches for in situ studies.
Pharmaceutical research 1997;14(4):463-8.
1997: Peracchia M T; Vauthier C; Puisieux F; Couvreur P
Development of sterically stabilized poly(isobutyl 2-cyanoacrylate) nanoparticles by chemical coupling of poly(ethylene glycol).
Journal of biomedical materials research 1997;34(3):317-26.
1997: Allaoui-Attarki K; Pecquet S; Fattal E; Trollé S; Chachaty E; Couvreur P; Andremont A
Protective immunity against Salmonella typhimurium elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly(DL-lactide-co-glycolide) microspheres.
Infection and immunity 1997;65(3):853-7.
1997: Peracchia M T; Vauthier C; Passirani C; Couvreur P; Labarre D
Complement consumption by poly(ethylene glycol) in different conformations chemically coupled to poly(isobutyl 2-cyanoacrylate) nanoparticles.
Life sciences 1997;61(7):749-61.

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