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Patrick Couvreur

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Hervé Hillaireau; Sinda Lepêtre; Christine Rogez-Kreuz; Bernard Rousseau; Rym Skanji; Rahima Yousfi; Karine Andrieux; Sébastien Argote; Laurent Bauduin; Fawzia Bekkara-Aounallah; Joachim Caron; Pascal Clayette; Nathalie Dereuddre-Bosquet; Didier Desmaële; Ruxandra Gref; Patrick Couvreur
Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies.
Simon Harrisson; Andrei Maksimenko; Julie Mougin; Julien Nicolas; Duc Trung Bui; Patrick Couvreur
Nanoparticles with in vivo anticancer activity from polymer prodrug amphiphiles prepared by living radical polymerization.
Joachim Caron; Patrick Couvreur; Claudie Bourgaux; Karine Leblanc; Elise Lepeltier; Andrei Maksimenko; Estelle Morvan; Séverine Wack; Didier Desmaële
Improving the antitumor activity of squalenoyl-paclitaxel conjugate nanoassemblies by manipulating the linker between paclitaxel and squalene.

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All Publications

2013: Hervé Hillaireau; Sinda Lepêtre; Christine Rogez-Kreuz; Bernard Rousseau; Rym Skanji; Rahima Yousfi; Karine Andrieux; Sébastien Argote; Laurent Bauduin; Fawzia Bekkara-Aounallah; Joachim Caron; Pascal Clayette; Nathalie Dereuddre-Bosquet; Didier Desmaële; Ruxandra Gref; Patrick Couvreur
Anti-HIV efficacy and biodistribution of nucleoside reverse transcriptase inhibitors delivered as squalenoylated prodrug nanoassemblies.
Biomaterials 2013;34(20):4831-8.
2013: Simon Harrisson; Andrei Maksimenko; Julie Mougin; Julien Nicolas; Duc Trung Bui; Patrick Couvreur
Nanoparticles with in vivo anticancer activity from polymer prodrug amphiphiles prepared by living radical polymerization.
Angewandte Chemie (International ed. in English) 2013;52(6):1678-82.
2013: Joachim Caron; Patrick Couvreur; Claudie Bourgaux; Karine Leblanc; Elise Lepeltier; Andrei Maksimenko; Estelle Morvan; Séverine Wack; Didier Desmaële
Improving the antitumor activity of squalenoyl-paclitaxel conjugate nanoassemblies by manipulating the linker between paclitaxel and squalene.
Advanced healthcare materials 2013;2(1):172-85.
2013: Patrick Couvreur
Nanoparticles in drug delivery: past, present and future.
Advanced drug delivery reviews 2013;65(1):21-3.
2012: L Harivardhan Reddy; Julien Nicolas; José L Arias; Patrick Couvreur
Magnetic nanoparticles: design and characterization, toxicity and biocompatibility, pharmaceutical and biomedical applications.
Chemical reviews 2012;112(11):5818-78.
2012: Tarek Baati; Patrick Couvreur; Olivier David; Ruxandra Gref; Patricia Horcajada; Christian Serre
Quantification of tetramethyl-terephthalic acid in rat liver, spleen and urine matrices by liquid-liquid phase extraction and HPLC-photodiode array detection.
Journal of pharmaceutical and biomedical analysis 2012;67-68():98-103.
2012: Benjamin Le Droumaguet; Noiray Magali; Andrei Maksimenko; Massimo Masserini; Simona Mura; Julien Nicolas; Francesco Nicotra; Elisa Salvati; Wiep Scheper; Cristiano Zona; Cristina Airoldi; Karine Andrieux; Davide Brambilla; Mara Canovi; Line De Kimpe; Orfeu Flores; Marco Gobbi; Barbara La Ferla; Patrick Couvreur
Versatile and efficient targeting using a single nanoparticulate platform: application to cancer and Alzheimer's disease.
ACS nano 2012;6(7):5866-79.
2012: Davide Brambilla; Mara Canovi; Patrick Couvreur; Line De Kimpe; Marco Gobbi; S Hossein Hashemi; Juraj Kóňa; Benjamin Le Droumaguet; Barbara Lettiero; S Moein Moghimi; Julien Nicolas; Valérie Nicolas; Wiep Scheper; Myriam Taverna; Igor Tvaroška; Romain Verpillot; Karine Andrieux
PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: toward engineering of functional nanomedicines for Alzheimer's disease.
ACS nano 2012;6(7):5897-908.
2012: Nicolas Sémiramoth; Sabrina Valetti; Fatima Zouhiri; Chiara Di Meo; Didier Desmaële; Roseline Gorges; Ruxandra Gref; Valérie Nicolas; Jacques H Poupaert; Fatouma Saïd-Hassane; Sylvie Chollet-Martin; Patrick Couvreur
Self-assembled squalenoylated penicillin bioconjugates: an original approach for the treatment of intracellular infections.
ACS nano 2012;6(5):3820-31.
2012: Simon Harrisson; Patrick Couvreur; Julien Nicolas
Use of solvent effects to improve control over nitroxide-mediated polymerization of isoprene.
Macromolecular rapid communications 2012;33(9):805-10.
2012: Vanessa Allain; Claudie Bourgaux; Patrick Couvreur
Self-assembled nucleolipids: from supramolecular structure to soft nucleic acid and drug delivery devices.
Nucleic acids research 2012;40(5):1891-903.
2012: Patricia Horcajada; Guillaume Maurin; Russell E Morris; Phoebe K Allan; Tarek Baati; Patrick Couvreur; Gérard Férey; Ruxandra Gref; Christian Serre
Metal-organic frameworks in biomedicine.
Chemical reviews 2012;112(2):1232-68.
2011: Tarek Baati; Patrick Couvreur; Ruxandra Gref; Patricia Horcajada; Christian Serre
Quantification of fumaric acid in liver, spleen and urine by high-performance liquid chromatography coupled to photodiode-array detection.
Journal of pharmaceutical and biomedical analysis 2011;56(4):758-62.
2011: T Chalati; Patrick Couvreur; Patricia Horcajada; Guillaume Maurin; C Serre; M Ben Yahia; Ruxandra Gref
Porous metal organic framework nanoparticles to address the challenges related to busulfan encapsulation.
Nanomedicine (London, England) 2011;6(10):1683-95.
2011: L Bildstein; Claudie Bourgaux; Patrick Couvreur; Didier Desmaële; S Lepêtre-Mouelhi; Véronique Marsaud; F Meneau; B Pili; S Wack; Catherine Dubernet
Interaction of an amphiphilic squalenoyl prodrug of gemcitabine with cellular membranes.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2011;79(3):612-20.
2011: Davide Brambilla; Patrick Couvreur; S Hossein Hashemi; Benjamin Le Droumaguet; S Moein Moghimi; Julien Nicolas; Lin-Ping Wu; Karine Andrieux
Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues.
Nanomedicine : nanotechnology, biology, and medicine 2011;7(5):521-40.
2011: Benjamin Le Droumaguet; Julien Nicolas; Hayfa Souguir; Myriam Taverna; Romain Verpillot; Davide Brambilla; Patrick Couvreur; Karine Andrieux
Selegiline-functionalized, PEGylated poly(alkyl cyanoacrylate) nanoparticles: Investigation of interaction with amyloid-β peptide and surface reorganization.
International journal of pharmaceutics 2011;416(2):453-60.
2011: Tarek Baati; Patrick Couvreur; Ruxandra Gref; Patricia Horcajada; Christian Serre
Quantification of trimesic acid in liver, spleen and urine by high-performance liquid chromatography coupled to a photodiode-array detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(23):2311-4.
2011: Mouna Raouane; Fatima Zouhiri; Ridha Ben Salah; Claudie Bourgaux; Gary Clayman; Didier Desmaele; Marie Gilbert-Sirieix; Ruxandra Gref; Claire Gueutin; Elise Lepeltier; Liliane Massaad-Massade; Patrick Couvreur
Synthesis, characterization, and in vivo delivery of siRNA-squalene nanoparticles targeting fusion oncogene in papillary thyroid carcinoma.
Journal of medicinal chemistry 2011;54(12):4067-76.
2011: Mohammad Othman; Didier Desmaële; Patrick Couvreur; Luce Vander Elst; Sophie Laurent; Robert N Muller; Claudie Bourgaux; Estelle Morvan; Thierry Pouget; Sinda Lepêtre-Mouelhi; Philippe Durand; Ruxandra Gref
Synthesis and physicochemical characterization of new squalenoyl amphiphilic gadolinium complexes as nanoparticle contrast agents.
Organic & biomolecular chemistry 2011;9(11):4367-86.
2011: Anshuman Ambike; Véronique Rosilio; Barbara Stella; Sinda Lepêtre-Mouelhi; Patrick Couvreur
Interaction of self-assembled squalenoyl gemcitabine nanoparticles with phospholipid-cholesterol monolayers mimicking a biomembrane.
Langmuir : the ACS journal of surfaces and colloids 2011;27(8):4891-9.
2011: José L Arias; L Harivardhan Reddy; Mohammad Othman; Brigitte Gillet; Didier Desmaële; Fatima Zouhiri; Franco Dosio; Ruxandra Gref; Patrick Couvreur
Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics.
ACS nano 2011;5(2):1513-21.
2011: Mohammad Othman; Kawthar Bouchemal; Patrick Couvreur; Didier Desmaële; Estelle Morvan; Thierry Pouget; Ruxandra Gref
A comprehensive study of the spontaneous formation of nanoassemblies in water by a "lock-and-key" interaction between two associative polymers.
Journal of colloid and interface science 2011;354(2):517-27.
2011: José L Arias; L Harivardhan Reddy; Patrick Couvreur
Superior preclinical efficacy of gemcitabine developed as chitosan nanoparticulate system.
Biomacromolecules 2011;12(1):97-104.
2011: Christine Vauthier; Nicolas Tsapis; Patrick Couvreur
Nanoparticles: heating tumors to death?
Nanomedicine (London, England) 2011;6(1):99-109.
2010: Davide Brambilla; Patrick Couvreur; Benjamin Le Droumaguet; Nicolas Mackiewicz; Julien Nicolas; Hayfa Souguir; Myriam Taverna; Romain Verpillot; Karine Andrieux
Colloidal properties of biodegradable nanoparticles influence interaction with amyloid-β peptide.
Journal of biotechnology 2010;156(4):338-40.
2010: Davide Brambilla; Romain Verpillot; Myriam Taverna; Line De Kimpe; Benjamin Le Droumaguet; Julien Nicolas; Mara Canovi; Marco Gobbi; Francesco Mantegazza; Mario Salmona; Valérie Nicolas; Wiep Scheper; Patrick Couvreur; Karine Andrieux
New method based on capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) to monitor interaction between nanoparticles and the amyloid-β peptide.
Analytical chemistry 2010;82(24):10083-9.
2010: D Brambilla; R Verpillot; L De Kimpe; Myriam Taverna; B Le Droumaguet; J Nicolas; M Canovi; Marco Gobbi; Mario Salmona; V Nicolas; Wiep Scheper; Patrick Couvreur; Karine Andrieux
Nanoparticles against Alzheimer's disease: PEG-PACA nanoparticles are able to link the aβ-peptide and influence its aggregation kinetic.
Journal of controlled release : official journal of the Controlled Release Society 2010;148(1):e112-3.
2010: A L Laza-Knoerr; Ruxandra Gref; Patrick Couvreur
Cyclodextrins for drug delivery.
Journal of drug targeting 2010;18(9):645-56.
2010: Barbara Pili; L Harivardhan Reddy; Claudie Bourgaux; Sinda Lepêtre-Mouelhi; Didier Desmaële; Patrick Couvreur
Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation.
Nanoscale 2010;2(8):1521-6.
2010: Patricia Horcajada; Christian Serre; Gérard Férey; Patrick Couvreur; Ruxandra Gref
[Hybrid nanocarriers for controlled delivery of antitumour and retroviral drugs delivery].
Médecine sciences : M/S 2010;26(8-9):761-7.
2010: Barbara Pili; Claudie Bourgaux; Heinz Amenitsch; Gérard Keller; Sinda Lepêtre-Mouelhi; Didier Desmaële; Patrick Couvreur; Michel Ollivon
Interaction of a new anticancer prodrug, gemcitabine-squalene, with a model membrane: coupled DSC and XRD study.
Biochimica et biophysica acta 2010;1798(8):1522-32.
2010: Franco Dosio; L Harivardhan Reddy; Annalisa Ferrero; Barbara Stella; Luigi Cattel; Patrick Couvreur
Novel nanoassemblies composed of squalenoyl-paclitaxel derivatives: synthesis, characterization, and biological evaluation.
Bioconjugate chemistry 2010;21(7):1349-61.
2010: Joachim Caron; L Harivardhan Reddy; Sinda Lepêtre-Mouelhi; Séverine Wack; Pascal Clayette; Christine Rogez-Kreuz; Rahima Yousfi; Patrick Couvreur; Didier Desmaële
Squalenoyl nucleoside monophosphate nanoassemblies: new prodrug strategy for the delivery of nucleotide analogues.
Bioorganic & medicinal chemistry letters 2010;20(9):2761-4.
2010: Davide Brambilla; Julien Nicolas; Benjamin Le Droumaguet; Karine Andrieux; Véronique Marsaud; Pierre-Olivier Couraud; Patrick Couvreur
Design of fluorescently tagged poly(alkyl cyanoacrylate) nanoparticles for human brain endothelial cell imaging.
Chemical communications (Cambridge, England) 2010;46(15):2602-4.
2010: Henri de Martimprey; Jean-Rémi Bertrand; Claude Malvy; Patrick Couvreur; Christine Vauthier
New core-shell nanoparticules for the intravenous delivery of siRNA to experimental thyroid papillary carcinoma.
Pharmaceutical research 2010;27(3):498-509.
2010: Caroline Chemin; Jean-Manuel Péan; Alain Le Pape; Jean-Marie Delbos; Michèle German-Fattal; Patrick Wüthrich; Patrick Couvreur
Biodistribution and anticancer activity of a new Vinca alkaloid encapsulated into long-circulating liposomes.
Journal of liposome research 2010;20(1):62-72.
2009: L Harivardhan Reddy; Patrick Couvreur
Squalene: A natural triterpene for use in disease management and therapy.
Advanced drug delivery reviews 2009;61(15):1412-26.
2009: L Bildstein; H Hillaireau; Didier Desmaële; S Lepêtre-Mouelhi; Catherine Dubernet; Patrick Couvreur
Freeze-drying of squalenoylated nucleoside analogue nanoparticles.
International journal of pharmaceutics 2009;381(2):140-5.
2009: Mohammad Othman; Kawthar Bouchemal; Patrick Couvreur; Ruxandra Gref
Microcalorimetric investigation on the formation of supramolecular nanoassemblies of associative polymers loaded with gadolinium chelate derivatives.
International journal of pharmaceutics 2009;379(2):218-25.
2009: Karine Andrieux; Patrick Couvreur
Polyalkylcyanoacrylate nanoparticles for delivery of drugs across the blood-brain barrier.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2009;1(5):463-74.
2009: José L Arias; L Harivardhan Reddy; Patrick Couvreur
Polymeric nanoparticulate system augmented the anticancer therapeutic efficacy of gemcitabine.
Journal of drug targeting 2009;17(8):586-98.
2009: Hervé Hillaireau; Patrick Couvreur
Nanocarriers' entry into the cell: relevance to drug delivery.
Cellular and molecular life sciences : CMLS 2009;66(17):2873-96.
2009: Borislav Angelov; Angelina Angelova; Ulla Vainio; Vasil M Garamus; Sylviane Lesieur; Regine Willumeit; Patrick Couvreur
Long-living intermediates during a lamellar to a diamond-cubic lipid phase transition: a small-angle X-ray scattering investigation.
Langmuir : the ACS journal of surfaces and colloids 2009;25(6):3734-42.
2009: Samia Daoud-Mahammed; Patrick Couvreur; Kawthar Bouchemal; Monique Chéron; Geneviève Lebas; Catherine Amiel; Ruxandra Gref
Cyclodextrin and polysaccharide-based nanogels: entrapment of two hydrophobic molecules, benzophenone and tamoxifen.
Biomacromolecules 2009;10(3):547-54.
2009: H de Martimprey; Christine Vauthier; Claude Malvy; Patrick Couvreur
Polymer nanocarriers for the delivery of small fragments of nucleic acids: oligonucleotides and siRNA.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2009;71(3):490-504.
2009: Julien Nicolas; Patrick Couvreur
Synthesis of poly(alkyl cyanoacrylate)-based colloidal nanomedicines.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2009;1(1):111-27.
2008: Céline Bouclier; Laurence Moine; Hervé Hillaireau; Véronique Marsaud; Elisabeth Connault; Paule Opolon; Patrick Couvreur; Elias Fattal; Jack-Michel Renoir
Physicochemical characteristics and preliminary in vivo biological evaluation of nanocapsules loaded with siRNA targeting estrogen receptor alpha.
Biomacromolecules 2008;9(10):2881-90.
2008: L Harivardhan Reddy; Hania Khoury; Angelo Paci; Alain Deroussent; Humberto Ferreira; Catherine Dubernet; Xavier Declèves; Madeleine Besnard; Helène Chacun; Sinda Lepêtre-Mouelhi; Didier Desmaële; Bernard Rousseau; Christelle Laugier; Jean-Christophe Cintrat; Gilles Vassal; Patrick Couvreur
Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(8):1570-7.
2008: José L Arias; L Harivardhan Reddy; Patrick Couvreur
Magnetoresponsive squalenoyl gemcitabine composite nanoparticles for cancer active targeting.
Langmuir : the ACS journal of surfaces and colloids 2008;24(14):7512-9.
2008: Caroline Chemin; Claudie Bourgaux; Jean-Manuel Péan; Georg Pabst; Patrick Wüthrich; Patrick Couvreur; Michel Ollivon
Consequences of ions and pH on the supramolecular organization of sphingomyelin and sphingomyelin/cholesterol bilayers.
Chemistry and physics of lipids 2008;153(2):119-29.
2008: L Harivardhan Reddy; Pierre-Emmanuel Marque; Catherine Dubernet; Sinda-Lepêtre Mouelhi; Didier Desmaële; Patrick Couvreur
Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine.
The Journal of pharmacology and experimental therapeutics 2008;325(2):484-90.
2008: Pascal Breton; Virginie Larras; Didier Roy; Serge Sagodira; David Limal; David Bonnafous; Nathalie Colin; Nicole Bru; Elias Fattal; Patrick Couvreur
Biocompatible poly(methylidene malonate)-made materials for pharmaceutical and biomedical applications.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2008;68(3):479-95.
2008: Patrick Couvreur; L Harivardhan Reddy; Stéphanie Mangenot; Jacques H Poupaert; Didier Desmaële; Sinda Lepêtre-Mouelhi; Barbara Pili; Claudie Bourgaux; H Amenitsch; Michel Ollivon
Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue.
Small (Weinheim an der Bergstrasse, Germany) 2008;4(2):247-53.
2008: L Harivardhan Reddy; Patrick Couvreur
Novel approaches to deliver gemcitabine to cancers.
Current pharmaceutical design 2008;14(11):1124-37.
2008: Henri de Martimprey; Jean-Rémi Bertrand; Alfredo Fusco; Massimo Santoro; Patrick Couvreur; Christine Vauthier; Claude Malvy
siRNA nanoformulation against the ret/PTC1 junction oncogene is efficient in an in vivo model of papillary thyroid carcinoma.
Nucleic acids research 2008;36(1):e2.
2007: L Harivardhan Reddy; Catherine Dubernet; Sinda Lepetre Mouelhi; Pierre Emmanuel Marque; Didier Desmaele; Patrick Couvreur
A new nanomedicine of gemcitabine displays enhanced anticancer activity in sensitive and resistant leukemia types.
Journal of controlled release : official journal of the Controlled Release Society 2007;124(1-2):20-7.
2007: Jérôme BOULIGAND; Patrick Couvreur; Anne M Layre; Alain Deroussent; Angelo Paci; Etienne Delain; Gilles Vassal; Ruxandra Gref
Busulphan-loaded long-circulating nanospheres, a very attractive challenge for both galenists and pharmacologists.
Journal of microencapsulation 2007;24(8):715-30.
2007: Borislav Angelov; Angelina Angelova; Vasil M Garamus; Geneviève Lebas; Sylviane Lesieur; Michel Ollivon; Sérgio S Funari; Regine Willumeit; Patrick Couvreur
Small-angle neutron and X-ray scattering from amphiphilic stimuli-responsive diamond-type bicontinuous cubic phase.
Journal of the American Chemical Society 2007;129(44):13474-9.
2007: Barbara Stella; Silvia Arpicco; Flavio Rocco; Véronique Marsaud; Jack-Michel Renoir; Luigi Cattel; Patrick Couvreur
Encapsulation of gemcitabine lipophilic derivatives into polycyanoacrylate nanospheres and nanocapsules.
International journal of pharmaceutics 2007;344(1-2):71-7.
2007: M Lalanne; Karine Andrieux; Angelo Paci; M Besnard; Micheline Ré; Claudie Bourgaux; Michel Ollivon; D Desmaele; Patrick Couvreur
Liposomal formulation of a glycerolipidic prodrug for lymphatic delivery of didanosine via oral route.
International journal of pharmaceutics 2007;344(1-2):62-70.
2007: Hania Khoury; Alain Deroussent; L Harivardhan Reddy; Patrick Couvreur; Gilles Vassal; Angelo Paci
Simultaneous determination of gemcitabine and gemcitabine-squalene by liquid chromatography-tandem mass spectrometry in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;858(1-2):71-8.
2007: Hyun Ryoung Kim; Karine Andrieux; Claudine Delomenie; Hélène Chacun; Martine Appel; Didier Desmaële; Frédéric Taran; Dominique Georgin; Patrick Couvreur; Myriam Taverna
Analysis of plasma protein adsorption onto PEGylated nanoparticles by complementary methods: 2-DE, CE and Protein Lab-on-chip system.
Electrophoresis 2007;28(13):2252-61.
2007: Cédric Chauvierre; Liliane Leclerc; Denis Labarre; Martine Appel; Michael C Marden; Patrick Couvreur; Christine Vauthier
Enhancing the tolerance of poly(isobutylcyanoacrylate) nanoparticles with a modular surface design.
International journal of pharmaceutics 2007;338(1-2):327-32.
2007: Muriel Lalanne; Angelo Paci; Karine Andrieux; Nathalie Dereuddre-Bosquet; Pascal Clayette; Alain Deroussent; Micheline Ré; Gilles Vassal; Patrick Couvreur; Didier Desmaële
Synthesis and biological evaluation of two glycerolipidic prodrugs of didanosine for direct lymphatic delivery against HIV.
Bioorganic & medicinal chemistry letters 2007;17(8):2237-40.
2007: Samia Daoud-Mahammed; Patrick Couvreur; Ruxandra Gref
Novel self-assembling nanogels: stability and lyophilisation studies.
International journal of pharmaceutics 2007;332(1-2):185-91.
2007: Hyun R Kim; Karine Andrieux; Sophie Gil; Myriam Taverna; Hélène Chacun; Didier Desmaële; Frédéric Taran; Dominique Georgin; Patrick Couvreur
Translocation of poly(ethylene glycol-co-hexadecyl)cyanoacrylate nanoparticles into rat brain endothelial cells: role of apolipoproteins in receptor-mediated endocytosis.
Biomacromolecules 2007;8(3):793-9.
2007: Hervé Hillaireau; Trung Le Doan; H Chacun; J Janin; Patrick Couvreur
Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers.
International journal of pharmaceutics 2007;331(2):148-52.
2007: Samia Daoud-Mahammed; C Ringard-Lefebvre; N Razzouq; Véronique Rosilio; Brigitte Gillet; Patrick Couvreur; Catherine Amiel; Ruxandra Gref
Spontaneous association of hydrophobized dextran and poly-beta-cyclodextrin into nanoassemblies. Formation and interaction with a hydrophobic drug.
Journal of colloid and interface science 2007;307(1):83-93.
2007: Barbara Stella; Véronique Marsaud; Silvia Arpicco; Gérard Géraud; Luigi Cattel; Patrick Couvreur; Jack-Michel Renoir
Biological characterization of folic acid-conjugated poly(H2NPEGCA-co-HDCA) nanoparticles in cellular models.
Journal of drug targeting 2007;15(2):146-53.
2007: H Ryoung Kim; Sophie Gil; Karine Andrieux; V Nicolas; Martine Appel; Hélène Chacun; Didier Desmaële; Frédéric Taran; Dominique Georgin; Patrick Couvreur
Low-density lipoprotein receptor-mediated endocytosis of PEGylated nanoparticles in rat brain endothelial cells.
Cellular and molecular life sciences : CMLS 2007;64(3):356-64.
2006: Hervé Hillaireau; Trung Le Doan; Martine Appel; Patrick Couvreur
Hybrid polymer nanocapsules enhance in vitro delivery of azidothymidine-triphosphate to macrophages.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(3):346-52.
2006: Patrick Couvreur; Barbara Stella; L Harivardhan Reddy; Hervé Hillaireau; Catherine Dubernet; Didier Desmaële; Sinda Lepêtre-Mouelhi; Flavio Rocco; Nathalie Dereuddre-Bosquet; Pascal Clayette; Véronique Rosilio; Véronique Marsaud; Jack-Michel Renoir; Luigi Cattel
Squalenoyl nanomedicines as potential therapeutics.
Nano letters 2006;6(11):2544-8.
2006: Nedjma Toub; Claude Malvy; Elias Fattal; Patrick Couvreur
Innovative nanotechnologies for the delivery of oligonucleotides and siRNA.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2006;60(9):607-20.
2006: Anne-Magali Layre; Patrick Couvreur; Hélène Chacun; Caroline Aymes-Chodur; Nour Eddine Ghermani; Jacques H Poupaert; Joël Richard; Denis Requier; Ruxandra Gref
Busulfan loading into poly(alkyl cyanoacrylate) nanoparticles: physico-chemistry and molecular modeling.
Journal of biomedical materials research. Part B, Applied biomaterials 2006;79(2):254-62.
2006: Hervé Hillaireau; Trung Le Doan; M Besnard; H Chacun; J Janin; Patrick Couvreur
Encapsulation of antiviral nucleotide analogues azidothymidine-triphosphate and cidofovir in poly(iso-butylcyanoacrylate) nanocapsules.
International journal of pharmaceutics 2006;324(1):37-42.
2006: Isabelle Bertholon; Gilles Ponchel; Denis Labarre; Patrick Couvreur; Christine Vauthier
Bioadhesive properties of poly(alkylcyanoacrylate) nanoparticles coated with polysaccharide.
Journal of nanoscience and nanotechnology 2006;6(9-10):3102-9.
2006: Hervé Hillaireau; Trung Le Doan; Patrick Couvreur
Polymer-based nanoparticles for the delivery of nucleoside analogues.
Journal of nanoscience and nanotechnology 2006;6(9-10):2608-17.
2006: Anne-Magali Layre; Patrick Couvreur; Joël Richard; Denis Requier; N Eddine Ghermani; Ruxandra Gref
Freeze-drying of composite core-shell nanoparticles.
Drug development and industrial pharmacy 2006;32(7):839-46.
2006: Patrick Couvreur; Christine Vauthier
Nanotechnology: intelligent design to treat complex disease.
Pharmaceutical research 2006;23(7):1417-50.
2006: Borislav Angelov; Angelina Angelova; Brigitte Papahadjopoulos-Sternberg; Sylviane Lesieur; Jean-François Sadoc; Michel Ollivon; Patrick Couvreur
Detailed structure of diamond-type lipid cubic nanoparticles.
Journal of the American Chemical Society 2006;128(17):5813-7.
2006: Nedjma Toub; Jean-Rémi Bertrand; Ali Tamaddon; Hind Elhamess; Hervé Hillaireau; Andrei Maksimenko; Jean Maccario; Claude Malvy; Elias Fattal; Patrick Couvreur
Efficacy of siRNA nanocapsules targeted against the EWS-Fli1 oncogene in Ewing sarcoma.
Pharmaceutical research 2006;23(5):892-900.
2006: Ruxandra Gref; Catherine Amiel; Karine Molinard; Samia Daoud-Mahammed; Bernard Sébille; Brigitte Gillet; Jean-Claude Beloeil; Catherine Ringard; Véronique Rosilio; Jacques H Poupaert; Patrick Couvreur
New self-assembled nanogels based on host-guest interactions: characterization and drug loading.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(3):316-24.
2006: Anne-Magali Layre; Patrick Couvreur; Hélène Chacun; Joël Richard; Catherine Passirani; Denis Requier; Jean-Pierre Benoit; Ruxandra Gref
Novel composite core-shell nanoparticles as busulfan carriers.
Journal of controlled release : official journal of the Controlled Release Society 2006;111(3):271-80.
2006: Laurent Désiré; Evgueni Mysiakine; David Bonnafous; Patrick Couvreur; Serge Sagodira; Pascal Breton; Elias Fattal
Sustained delivery of growth factors from methylidene malonate 2.1.2-based polymers.
Biomaterials 2006;27(12):2609-20.
2006: Nedjma Toub; Jean-Rémi Bertrand; Claude Malvy; Elias Fattal; Patrick Couvreur
Antisense oligonucleotide nanocapsules efficiently inhibit EWS-Fli1 expression in a Ewing's sarcoma model.
Oligonucleotides 2006;16(2):158-68.
2006: Caroline Lemarchand; Ruxandra Gref; Catherine Passirani; EMMANUEL GARCION; Boris Petri; Rainer Müller; Dominique Costantini; Patrick Couvreur
Influence of polysaccharide coating on the interactions of nanoparticles with biological systems.
Biomaterials 2006;27(1):108-18.
2005: Caroline Lemarchand; Ruxandra Gref; Sylviane Lesieur; Hubert Hommel; Béatrice Vacher; Ahmed Besheer; Karsten Maeder; Patrick Couvreur
Physico-chemical characterization of polysaccharide-coated nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society 2005;108(1):97-111.
2005: Andrei Maksimenko; Valerie Polard; Marie Villemeur; Hind Elhamess; Patrick Couvreur; Jean-Rémi Bertrand; Malam Aboubakar; Marina Gottikh; Claude Malvy
In vivo potentialities of EWS-Fli-1 targeted antisense oligonucleotides-nanospheres complexes.
Annals of the New York Academy of Sciences 2005;1058():52-61.
2005: Laura Rabinovich-Guilatt; Catherine Dubernet; Karen Gaudin; Gregory Lambert; Patrick Couvreur; Pierre Chaminade
Phospholipid hydrolysis in a pharmaceutical emulsion assessed by physicochemical parameters and a new analytical method.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2005;61(1-2):69-76.
2005: Nedjma Toub; Chiara Angiari; Dominique Eboué; Elias Fattal; Jean-Pierre Tenu; Trung Le Doan; Patrick Couvreur
Cellular fate of oligonucleotides when delivered by nanocapsules of poly(isobutylcyanoacrylate).
Journal of controlled release : official journal of the Controlled Release Society 2005;106(1-2):209-13.
2005: Thomas Maignien; Monjed Shakweh; Pilar Calvo; Dominique Marcé; Nicole Salès; Elias Fattal; Jean-Philippe Deslys; Patrick Couvreur; Corinne Ida Lasmezas
Role of gut macrophages in mice orally contaminated with scrapie or BSE.
International journal of pharmaceutics 2005;298(2):293-304.
2005: Elizabeth Garcia-Garcia; Karine Andrieux; Sophie Gil; Hyun Ryoung Kim; Trung Le Doan; Didier Desmaële; Jean d'Angelo; Frédéric Taran; Dominique Georgin; Patrick Couvreur
A methodology to study intracellular distribution of nanoparticles in brain endothelial cells.
International journal of pharmaceutics 2005;298(2):310-4.
2005: Anne-Magali Layre; Ruxandra Gref; Joël Richard; Denis Requier; Hélène Chacun; Martine Appel; Abraham J Domb; Patrick Couvreur
Nanoencapsulation of a crystalline drug.
International journal of pharmaceutics 2005;298(2):323-7.
2005: Elizabeth Garcia-Garcia; Karine Andrieux; Sophie Gil; Patrick Couvreur
Colloidal carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain?
International journal of pharmaceutics 2005;298(2):274-92.
2005: Elizabeth Garcia-Garcia; Sophie Gil; Karine Andrieux; Didier Desmaële; V Nicolas; Frédéric Taran; Dominique Georgin; Jean P Andreux; F Roux; Patrick Couvreur
A relevant in vitro rat model for the evaluation of blood-brain barrier translocation of nanoparticles.
Cellular and molecular life sciences : CMLS 2005;62(12):1400-8.
2005: Angelina Angelova; Borislav Angelov; Brigitte Papahadjopoulos-Sternberg; Claudie Bourgaux; Patrick Couvreur
Protein driven patterning of self-assembled cubosomic nanostructures: long oriented nanoridges.
The journal of physical chemistry. B 2005;109(8):3089-93.
2004: Yvonne de Kozak; Karine Andrieux; Henri Villarroya; Christophe Klein; Brigitte Thillaye-Goldenberg; Marie-Christine Naud; Elisabeth Garcia; Patrick Couvreur
Intraocular injection of tamoxifen-loaded nanoparticles: a new treatment of experimental autoimmune uveoretinitis.
European journal of immunology 2004;34(12):3702-12.
2004: Irène Brigger; Jackie Morizet; Lysiane Laudani; Geneviève Aubert; Martine Appel; Valérie Velasco; Marie-José Terrier-Lacombe; Didier Desmaële; Jean d'Angelo; Patrick Couvreur; Gilles Vassal
Negative preclinical results with stealth nanospheres-encapsulated Doxorubicin in an orthotopic murine brain tumor model.
Journal of controlled release : official journal of the Controlled Release Society 2004;100(1):29-40.
2004: Caroline Lemarchand; Ruxandra Gref; Patrick Couvreur
Polysaccharide-decorated nanoparticles.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2004;58(2):327-41.
2004: Laura Rabinovich-Guilatt; Patrick Couvreur; Gregory Lambert; Danny Goldstein; Simon Benita; Catherine Dubernet
Extensive surface studies help to analyse zeta potential data: the case of cationic emulsions.
Chemistry and physics of lipids 2004;131(1):1-13.
2004: Cédric Chauvierre; Michael C Marden; Christine Vauthier; Denis Labarre; Patrick Couvreur; Liliane Leclerc
Heparin coated poly(alkylcyanoacrylate) nanoparticles coupled to hemoglobin: a new oxygen carrier.
Biomaterials 2004;25(15):3081-6.
2004: Cédric Chauvierre; Christine Vauthier; Denis Labarre; Patrick Couvreur; Michael C Marden; Liliane Leclerc
A new generation of polymer nanoparticles for drug delivery.
Cellular and molecular biology (Noisy-le-Grand, France) 2004;50(3):233-9.
2004: Elias Fattal; Patrick Couvreur; Catherine Dubernet
"Smart" delivery of antisense oligonucleotides by anionic pH-sensitive liposomes.
Advanced drug delivery reviews 2004;56(7):931-46.
2004: Nour Eddine Ghermani; Anne Spasojević-de Biré; Nouzha Bouhmaida; Souad Ouharzoune; Jérôme BOULIGAND; Anne-Magali Layre; Ruxandra Gref; Patrick Couvreur
Molecular reactivity of busulfan through its experimental electrostatic properties in the solid state.
Pharmaceutical research 2004;21(4):598-607.
2004: Laura Rabinovich-Guilatt; Patrick Couvreur; Gregory Lambert; Catherine Dubernet
Cationic vectors in ocular drug delivery.
Journal of drug targeting 2004;12(9-10):623-33.
2003: Christine Vauthier; Catherine Dubernet; Cédric Chauvierre; Irène Brigger; Patrick Couvreur
Drug delivery to resistant tumors: the potential of poly(alkyl cyanoacrylate) nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society 2003;93(2):151-60.
2003: Andrei Maksimenko; Gregory Lambert; Jean-Rémi Bertrand; Elias Fattal; Patrick Couvreur; Claude Malvy
Therapeutic potentialities of EWS-Fli-1 mRNA-targeted vectorized antisense oligonucleotides.
Annals of the New York Academy of Sciences 2003;1002():72-7.
2003: Cédric Chauvierre; Denis Labarre; Patrick Couvreur; Christine Vauthier
Novel polysaccharide-decorated poly(isobutyl cyanoacrylate) nanoparticles.
Pharmaceutical research 2003;20(11):1786-93.
2003: Ruxandra Gref; Patrick Couvreur; Gillian Barratt; Evgueni Mysiakine
Surface-engineered nanoparticles for multiple ligand coupling.
Biomaterials 2003;24(24):4529-37.
2003: Andrei Maksimenko; Claude Malvy; Gregory Lambert; Jean-Rémi Bertrand; Elias Fattal; Jean Maccario; Patrick Couvreur
Oligonucleotides targeted against a junction oncogene are made efficient by nanotechnologies.
Pharmaceutical research 2003;20(10):1565-7.
2003: Caroline Lemarchand; Patrick Couvreur; Madeleine Besnard; Dominique Costantini; Ruxandra Gref
Novel polyester-polysaccharide nanoparticles.
Pharmaceutical research 2003;20(8):1284-92.
2003: Huguette Pinto-Alphandary; Malam Aboubakar; Danielle Jaillard; Patrick Couvreur; Christine Vauthier
Visualization of insulin-loaded nanocapsules: in vitro and in vivo studies after oral administration to rats.
Pharmaceutical research 2003;20(7):1071-84.
2003: H Teixeira; Catherine Dubernet; Hélène Chacun; L Rabinovich; Valérie Boutet; Jean-Robert Deverre; Simon Benita; Patrick Couvreur
Cationic emulsions improves the delivery of oligonucleotides to leukemic P388/ADR cells in ascite.
Journal of controlled release : official journal of the Controlled Release Society 2003;89(3):473-82.
2003: Christine Vauthier; Catherine Dubernet; Elias Fattal; Huguette Pinto-Alphandary; Patrick Couvreur
Poly(alkylcyanoacrylates) as biodegradable materials for biomedical applications.
Advanced drug delivery reviews 2003;55(4):519-48.
2003: Irène Brigger; Laurence Armand-Lefevre; Pierre Chaminade; Madeleine Besnard; Yohan Rigaldie; Alain Largeteau; Antoine Andremont; Luc Grislain; Gérard Demazeau; Patrick Couvreur
The stenlying effect of high hydrostatic pressure on thermally and hydrolytically labile nanosized carriers.
Pharmaceutical research 2003;20(4):674-83.
2003: Caroline Lemarchand; Patrick Couvreur; Christine Vauthier; Dominique Costantini; Ruxandra Gref
Study of emulsion stabilization by graft copolymers using the optical analyzer Turbiscan.
International journal of pharmaceutics 2003;254(1):77-82.
2002: Irène Brigger; Jackie Morizet; Geneviève Aubert; Hélène Chacun; Marie-José Terrier-Lacombe; Patrick Couvreur; Gilles Vassal
Poly(ethylene glycol)-coated hexadecylcyanoacrylate nanospheres display a combined effect for brain tumor targeting.
The Journal of pharmacology and experimental therapeutics 2002;303(3):928-36.
2002: Irène Brigger; Catherine Dubernet; Patrick Couvreur
Nanoparticles in cancer therapy and diagnosis.
Advanced drug delivery reviews 2002;54(5):631-51.
2002: Elias Fattal; Sophie Pecquet; Patrick Couvreur; Antoine Andremont
Biodegradable microparticles for the mucosal delivery of antibacterial and dietary antigens.
International journal of pharmaceutics 2002;242(1-2):15-24.
2002: Pilar Calvo; Bruno Gouritin; Henri Villarroya; Françoise Eclancher; Claudia Giannavola; Christophe Klein; Jean P Andreux; Patrick Couvreur
Quantification and localization of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during experimental allergic encephalomyelitis in the rat.
The European journal of neuroscience 2002;15(8):1317-26.
2002: Vincent Beringue; Patrick Couvreur; Dominique Dormont
Involvement of macrophages in the pathogenesis of transmissible spongiform encephalopathies.
Developmental immunology 2002;9(1):19-27.
2002: Elias Fattal; Patrick Couvreur; Sophie Pecquet
[Oral tolerance induced by poly (lactide-co-glycolide) containing B lactoglobulin].
Annales pharmaceutiques françaises 2002;60(1):44-9.
2002: Amélie Bochot; Elias Fattal; Valérie Boutet; Jean-Robert Deverre; Jean-Claude Jeanny; Hélène Chacun; Patrick Couvreur
Intravitreal delivery of oligonucleotides by sterically stabilized liposomes.
Investigative ophthalmology & visual science 2002;43(1):253-9.
2001: Pilar Calvo; Bruno Gouritin; I Brigger; Corinne Ida Lasmezas; Jean-Philippe Deslys; A Williams; Jean P Andreux; Dominique Dormont; Patrick Couvreur
PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases.
Journal of neuroscience methods 2001;111(2):151-5.
2001: H Teixeira; Véronique Rosilio; A Laigle; Jean Lepault; Inge Erk; D Scherman; Simon Benita; Patrick Couvreur; Catherine Dubernet
Characterization of oligonucleotide/lipid interactions in submicron cationic emulsions: influence of the cationic lipid structure and the presence of PEG-lipids.
Biophysical chemistry 2001;92(3):169-81.
2001: Pilar Calvo; Bruno Gouritin; Hélène Chacun; Didier Desmaële; Jean d'Angelo; J P Noel; Dominique Georgin; Elias Fattal; Jean P Andreux; Patrick Couvreur
Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery.
Pharmaceutical research 2001;18(8):1157-66.
2001: Catherine Le Visage; fabiana Quaglia; Michel Dreux; S Ounnar; Pascal Breton; N Bru; Patrick Couvreur; Elias Fattal
Novel microparticulate system made of poly(methylidene malonate 2.1.2).
Biomaterials 2001;22(16):2229-38.
2001: Catherine Le Visage; Patrick Couvreur; Evgueni Mysiakine; Pascal Breton; N Bru; Elias Fattal
In vitro and in vivo evaluation of poly(methylidene malonate 2.1.2) microparticles behavior for oral administration.
Journal of drug targeting 2001;9(2):141-53.
2001: G Lambert; Elias Fattal; Patrick Couvreur
Nanoparticulate systems for the delivery of antisense oligonucleotides.
Advanced drug delivery reviews 2001;47(1):99-112.
2001: Irène Brigger; Pierre Chaminade; V Marsaud; Martine Appel; Madeleine Besnard; R Gurny; Michel J Renoir; Patrick Couvreur
Tamoxifen encapsulation within polyethylene glycol-coated nanospheres. A new antiestrogen formulation.
International journal of pharmaceutics 2001;214(1-2):37-42.
2001: Sara Nicoli; Patrizia Santi; Patrick Couvreur; Guy Couarraze; Paolo Colombo; Elias Fattal
Design of triptorelin loaded nanospheres for transdermal iontophoretic administration.
International journal of pharmaceutics 2001;214(1-2):31-5.
2001: Gregory Lambert; Elias Fattal; Huguette Pinto-Alphandary; Annette Gulik; Patrick Couvreur
Polyisobutylcyanoacrylate nanocapsules containing an aqueous core for the delivery of oligonucleotides.
International journal of pharmaceutics 2001;214(1-2):13-6.
2001: H Teixeira; Catherine Dubernet; Véronique Rosilio; A Laigle; Jean-Robert Deverre; D Scherman; Simon Benita; Patrick Couvreur
Factors influencing the oligonucleotides release from O-W submicron cationic emulsions.
Journal of controlled release : official journal of the Controlled Release Society 2001;70(1-2):243-55.
2000: Gregory Lambert; Jean-Rémi Bertrand; Elias Fattal; Frédéric Subra; Huguette Pinto-Alphandary; Claude Malvy; Christian Auclair; Patrick Couvreur
EWS fli-1 antisense nanocapsules inhibits ewing sarcoma-related tumor in mice.
Biochemical and biophysical research communications 2000;279(2):401-6.
2000: Barbara Stella; Silvia Arpicco; MT Peracchia; Didier Desmaële; J Hoebeke; Michel J Renoir; Jean d'Angelo; Luigi Cattel; Patrick Couvreur
Design of folic acid-conjugated nanoparticles for drug targeting.
Journal of pharmaceutical sciences 2000;89(11):1452-64.
2000: Mônica C de Oliveira; Véronique Rosilio; Pierre Lesieur; Claudie Bourgaux; Patrick Couvreur; Michel Ollivon; Catherine Dubernet
pH-sensitive liposomes as a carrier for oligonucleotides: a physico-chemical study of the interaction between DOPE and a 15-mer oligonucleotide in excess water.
Biophysical chemistry 2000;87(2-3):127-37.
2000: H Teixeira; Catherine Dubernet; Véronique Rosilio; Simon Benita; Jean Lepault; Inge Erk; Patrick Couvreur
New bicompartmental structures are observed when stearylamine is mixed with triglyceride emulsions.
Pharmaceutical research 2000;17(10):1329-32.
2000: Irène Brigger; Pierre Chaminade; Didier Desmaële; MT Peracchia; Jean d'Angelo; R Gurny; Michel J Renoir; Patrick Couvreur
Near infrared with principal component analysis as a novel analytical approach for nanoparticle technology.
Pharmaceutical research 2000;17(9):1124-32.
2000: Mônica C de Oliveira; Valérie Boutet; Elias Fattal; Didier Boquet; JM Grognet; Patrick Couvreur; Jean-Robert Deverre
Improvement of in vivo stability of phosphodiester oligonucleotide using anionic liposomes in mice.
Life sciences 2000;67(13):1625-37.
2000: S Trolle; Elisabeth Chachaty; N Kassis-Chikhani; C Wang; Elias Fattal; Patrick Couvreur; Betty Diamond; J Alonso; Antoine Andremont
Intranasal immunization with protein-linked phosphorylcholine protects mice against a lethal intranasal challenge with streptococcus pneumoniae.
Vaccine 2000;18(26):2991-8.
2000: Gregory Lambert; Elias Fattal; Huguette Pinto-Alphandary; Annette Gulik; Patrick Couvreur
Polyisobutylcyanoacrylate nanocapsules containing an aqueous core as a novel colloidal carrier for the delivery of oligonucleotides.
Pharmaceutical research 2000;17(6):707-14.
2000: Vincent Beringue; M Demoy; Corinne Ida Lasmézas; Bruno Gouritin; C Weingarten; Jean-Philippe Deslys; Jean P Andreux; Patrick Couvreur; Dominique Dormont
Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis.
The Journal of pathology 2000;190(4):495-502.
2000: Sophie Pecquet; Eliana Leo; Rodolphe Fritsché; A Pfeifer; Patrick Couvreur; Elias Fattal
Oral tolerance elicited in mice by beta-lactoglobulin entrapped in biodegradable microspheres.
Vaccine 2000;18(13):1196-202.
2000: Vincent Beringue; François Lamoury; Karim Adjou; Thomas Maignien; M Demoy; Patrick Couvreur; Dominique Dormont
Pharmacological manipulation of early PrPres accumulation in the spleen of scrapie-infected mice.
Archives of virology. Supplementum 2000;(16):39-56.
1999: Malam Aboubakar; F Puisieux; Patrick Couvreur; M Deyme; Christine Vauthier
Study of the mechanism of insulin encapsulation in poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization.
Journal of biomedical materials research 1999;47(4):568-76.
1999: Stéphane GIBAUD; C Weingarten; Jean P Andreux; Patrick Couvreur
[Targeting bone marrow with the help of polyalkylcyanoacrylate nanoparticles].
Annales pharmaceutiques françaises 1999;57(4):324-31.
1999: MT Peracchia; S Harnisch; Huguette Pinto-Alphandary; Annette Gulik; JC Dedieu; Didier Desmaële; Jean d'Angelo; R H Müller; Patrick Couvreur
Visualization of in vitro protein-rejecting properties of PEGylated stealth polycyanoacrylate nanoparticles.
Biomaterials 1999;20(14):1269-75.
1999: MT Peracchia; Elias Fattal; Didier Desmaële; M Besnard; J P Noël; J M Gomis; Martine Appel; Jean d'Angelo; Patrick Couvreur
Stealth PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting.
Journal of controlled release : official journal of the Controlled Release Society 1999;60(1):121-8.
1999: J Rojas; Huguette Pinto-Alphandary; Eliana Leo; Sophie Pecquet; Patrick Couvreur; Elias Fattal
Optimization of the encapsulation and release of beta-lactoglobulin entrapped poly(DL-lactide-co-glycolide) microspheres.
International journal of pharmaceutics 1999;183(1):67-71.
1999: Malam Aboubakar; F Puisieux; Patrick Couvreur; Christine Vauthier
Physico-chemical characterization of insulin-loaded poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization.
International journal of pharmaceutics 1999;183(1):63-6.
1999: J Rojas; Huguette Pinto-Alphandary; Eliana Leo; Sophie Pecquet; Patrick Couvreur; Annette Gulik; Elias Fattal
A polysorbate-based non-ionic surfactant can modulate loading and release of beta-lactoglobulin entrapped in multiphase poly(DL-lactide-co-glycolide) microspheres.
Pharmaceutical research 1999;16(2):255-60.
1999: M Demoy; Jean P Andreux; C Weingarten; Bruno Gouritin; V Guilloux; Patrick Couvreur
In vitro evaluation of nanoparticles spleen capture.
Life sciences 1999;64(15):1329-37.
1999: M Demoy; Jean P Andreux; C Weingarten; Bruno Gouritin; V Guilloux; Patrick Couvreur
Spleen capture of nanoparticles: influence of animal species and surface characteristics.
Pharmaceutical research 1999;16(1):37-41.
1999: H Teixeira; Catherine Dubernet; F Puisieux; Simon Benita; Patrick Couvreur
Submicron cationic emulsions as a new delivery system for oligonucleotides.
Pharmaceutical research 1999;16(1):30-6.
1998: M E Page-Clisson; H Pinto-Alphandary; M Ourevitch; Antoine Andremont; Patrick Couvreur
Development of ciprofloxacin-loaded nanoparticles: physicochemical study of the drug carrier.
Journal of controlled release : official journal of the Controlled Release Society 1998;56(1-3):23-32.
1998: Amélie Bochot; Elias Fattal; Annette Gulik; Guy Couarraze; Patrick Couvreur
Liposomes dispersed within a thermosensitive gel: a new dosage form for ocular delivery of oligonucleotides.
Pharmaceutical research 1998;15(9):1364-9.
1998: Mônica C de Oliveira; Elias Fattal; Patrick Couvreur; Pierre Lesieur; Claudie Bourgaux; Michel Ollivon; Catherine Dubernet
pH-sensitive liposomes as a carrier for oligonucleotides: a physico-chemical study of the interaction between DOPE and a 15-mer oligonucleotide in quasi-anhydrous samples.
Biochimica et biophysica acta 1998;1372(2):301-10.
1998: Eliana Leo; Sophie Pecquet; J Rojas; Patrick Couvreur; Elias Fattal
Changing the pH of the external aqueous phase may modulate protein entrapment and delivery from poly(lactide-co-glycolide) microspheres prepared by a w/o/w solvent evaporation method.
Journal of microencapsulation 1998;15(4):421-30.
1998: MT Peracchia; Christine Vauthier; Didier Desmaële; Annette Gulik; JC Dedieu; M Demoy; Jean d'Angelo; Patrick Couvreur
Pegylated nanoparticles from a novel methoxypolyethylene glycol cyanoacrylate-hexadecyl cyanoacrylate amphiphilic copolymer.
Pharmaceutical research 1998;15(4):550-6.
1998: M E Page-Clisson; H Pinto-Alphandary; Elisabeth Chachaty; Patrick Couvreur; Antoine Andremont
Drug targeting by polyalkylcyanoacrylate nanoparticles is not efficient against persistent Salmonella.
Pharmaceutical research 1998;15(4):544-9.
1998: K Allaoui-Attarki; Elias Fattal; Sophie Pecquet; S Trollé; Elisabeth Chachaty; Patrick Couvreur; Antoine Andremont
Mucosal immunogenicity elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly (D,L-lactide-co-glycolide) microspheres.
Vaccine 1998;16(7):685-91.
1998: Stéphane GIBAUD; C Rousseau; C Weingarten; R Favier; Luc Douay; Jean P Andreux; Patrick Couvreur
Polyalkylcyanoacrylate nanoparticles as carriers for granulocyte-colony stimulating factor (G-CSF).
Journal of controlled release : official journal of the Controlled Release Society 1998;52(1-2):131-9.
1998: Amélie Bochot; B Mashhour; F Puisieux; Patrick Couvreur; Elias Fattal
Comparison of the ocular distribution of a model oligonucleotide after topical instillation in rabbits of conventional and new dosage forms.
Journal of drug targeting 1998;6(4):309-13.
1997: M Demoy; Stéphane GIBAUD; Jean P Andreux; C Weingarten; Bruno Gouritin; Patrick Couvreur
Splenic trapping of nanoparticles: complementary approaches for in situ studies.
Pharmaceutical research 1997;14(4):463-8.
1997: MT Peracchia; Christine Vauthier; F Puisieux; Patrick Couvreur
Development of sterically stabilized poly(isobutyl 2-cyanoacrylate) nanoparticles by chemical coupling of poly(ethylene glycol).
Journal of biomedical materials research 1997;34(3):317-26.
1997: K Allaoui-Attarki; Sophie Pecquet; Elias Fattal; S Trollé; Elisabeth Chachaty; Patrick Couvreur; Antoine Andremont
Protective immunity against Salmonella typhimurium elicited in mice by oral vaccination with phosphorylcholine encapsulated in poly(DL-lactide-co-glycolide) microspheres.
Infection and immunity 1997;65(3):853-7.
1997: MT Peracchia; Christine Vauthier; C Passirani; Patrick Couvreur; Denis Labarre
Complement consumption by poly(ethylene glycol) in different conformations chemically coupled to poly(isobutyl 2-cyanoacrylate) nanoparticles.
Life sciences 1997;61(7):749-61.