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James Allison

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Emily Corse; Rachel A Gottschalk; Linda K Johnson; P'ng Loke; Joon Seok Park; Manuel A Sepulveda; Timothy J Sullivan; James P Allison
Cutting edge: chronic inflammatory liver disease in mice expressing a CD28-specific ligand.
Jun Sik Lee; Juan Lin; P'ng Loke; Anjana Ray; Lisa Scandiuzzi; David V Serreze; Joyce Wei; Jianda Yuan; Yael M Abadi; James P Allison; Kimberly A Hofmeyer; Xingxing Zang
B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells.
Emily Corse; James P Allison
Cutting edge: CTLA-4 on effector T cells inhibits in trans.

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2013: Emily Corse; Rachel A Gottschalk; Linda K Johnson; P'ng Loke; Joon Seok Park; Manuel A Sepulveda; Timothy J Sullivan; James P Allison
Cutting edge: chronic inflammatory liver disease in mice expressing a CD28-specific ligand.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(2):526-30.
2012: Jun Sik Lee; Juan Lin; P'ng Loke; Anjana Ray; Lisa Scandiuzzi; David V Serreze; Joyce Wei; Jianda Yuan; Yael M Abadi; James P Allison; Kimberly A Hofmeyer; Xingxing Zang
B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(8):4165-74.
2012: Emily Corse; James P Allison
Cutting edge: CTLA-4 on effector T cells inhibits in trans.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(3):1123-7.
2012: Meili Zhang; Bih-Rong Wei; Zhengsheng Yao; Ping Yu; James P Allison; Marcella Fassò; Wei Ju; R Mark Simpson; Rebecca Waitz; Thomas A Waldmann
Augmented IL-15Rα expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):6156-64.
2012: Ping Yu; Meili Zhang; James P Allison; Marcella Fasso; John C Morris; Jason C Steel; Rebecca Waitz; Thomas A Waldmann
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(16):6187-92.
2012: Michael A Postow; Teresa Rasalan; Erika Ritter; Ruth-Ann Roman; Samuel Rosner; Christine Sedrak; Yoshiya Yamada; Arvin S Yang; Jianda Yuan; Matthew Adamow; James P Allison; Christopher A Barker; Brenna Benson; Margaret K Callahan; Ramon Chua; Sacha Gnjatic; Achim A Jungbluth; Shigehisa Kitano; Alexander M Lesokhin; Zhenyu Mu; Jedd D Wolchok
Immunologic correlates of the abscopal effect in a patient with melanoma.
The New England journal of medicine 2012;366(10):925-31.
2012: Hirokazu Matsushita; Lloyd J Old; Charles G Rickert; Lauren K Shea; Mark J Smyth; Ravindra Uppaluri; Matthew D Vesely; Michael Wendl; J Michael White; Todd Wylie; James P Allison; Cora D Arthur; Yee-Shiuan Chen; Ryan Demeter; Jasreet Hundal; Daniel C Koboldt; vincent magrini; Elaine R Mardis; Robert D Schreiber
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting.
Nature 2012;482(7385):400-4.
2012: Rachel A Gottschalk; Emily Corse; James P Allison
Expression of Helios in peripherally induced Foxp3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(3):976-80.
2012: Rachel A Gottschalk; Matthew M Hathorn; Gregoire Altan-Bonnet; Hélène Beuneu; Emily Corse; Michael L Dustin; James P Allison
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(3):881-6.
2012: Rebecca Waitz; Marcella Fassò; Larry Norton; Elena N Petre; Stephen B Solomon; Anne E Trumble; James P Allison
Potent induction of tumor immunity by combining tumor cryoablation with anti-CTLA-4 therapy.
Cancer research 2012;72(2):430-9.
2012: Robert R Jenq; Chen Liu; James P Allison; Michael A Curran; Gabrielle L Goldberg; Marcel R M van den Brink
Repertoire enhancement with adoptively transferred female lymphocytes controls the growth of pre-implanted murine prostate cancer.
PloS one 2012;7(4):e35222.
2011: Padmanee Sharma; Klaus Wagner; Jedd D Wolchok; James P Allison
Novel cancer immunotherapy agents with survival benefit: recent successes and next steps.
Nature reviews. Cancer 2011;11(11):805-12.
2011: Jianda Yuan; Matthew Adamow; James P Allison; Humilidad F Gallardo; Brian A Ginsberg; Ruth Halaban; Achim A Jungbluth; Deborah Kuk; Lloyd J Old; Katherine S Panageas; Evelina Pogoriler; Teresa S Rasalan; Erika Ritter; Gerd Ritter; Mario Sznol; Stephanie L Terzulli; Jedd D Wolchok; Yinyan Xu; Sacha Gnjatic
Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(40):16723-8.
2011: Jianda Yuan; Yinyan Xu; Sylvia Adams; James P Allison; Nina Bhardwaj; Klaus Busam; Humilidad F Gallardo; Brian Ginsberg; Achim Jungbluth; Yanyun Li; Lloyd J Old; David Page; Teresa Rasalan; Jedd D Wolchok
CTLA-4 blockade increases antigen-specific CD8(+) T cells in prevaccinated patients with melanoma: three cases.
Cancer immunology, immunotherapy : CII 2011;60(8):1137-46.
2011: Moses K Donkor; Ruth A Franklin; Linda Kassebaum Johnson; Achim A Jungbluth; Abira Sarkar; Peter A Savage; James P Allison; Ming O Li
T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokine.
Immunity 2011;35(1):123-34.
2011: Emily Corse; Rachel A Gottschalk; James P Allison
Strength of TCR-peptide/MHC interactions and in vivo T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(9):5039-45.
2011: Sergio Quezada; Karl S Peggs; Tyler R Simpson; James P Allison
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.
Immunological reviews 2011;241(1):104-18.
2011: Virginia A Pedicord; Welby Montalvo; Ingrid M Leiner; James P Allison
Single dose of anti-CTLA-4 enhances CD8+ T-cell memory formation, function, and maintenance.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(1):266-71.
2011: Michael A Curran; Myoungjoo Kim; Welby Montalvo; Aymen Al-Shamkhani; James P Allison
Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production.
PloS one 2011;6(4):e19499.
2010: Rachel A Gottschalk; Emily Corse; James P Allison
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo.
The Journal of experimental medicine 2010;207(8):1701-11.
2010: Xingxing Zang; Peggy S Sullivan; Robert A Soslow; Rebecca Waitz; Victor E Reuter; Andrew Wilton; Howard T Thaler; Manonmani Arul; Susan F Slovin; Joyce Wei; David Spriggs; Jakob Dupont; James P Allison
Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010;23(8):1104-12.
2010: Tyler R Simpson; Sergio Quezada; James P Allison
Regulation of CD4 T cell activation and effector function by inducible costimulator (ICOS).
Current opinion in immunology 2010;22(3):326-32.
2010: Geoffrey Y Ku; Jianda Yuan; David B Page; Sebastian E A Schroeder; Katherine S Panageas; Richard Carvajal; Paul B Chapman; Gary K Schwartz; James P Allison; Jedd D Wolchok
Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival.
Cancer 2010;116(7):1767-75.
2010: Sergio Quezada; Tyler R Simpson; Karl S Peggs; Taha Merghoub; Jelena Vider; Xiaozhou Fan; Ronald Blasberg; Hideo Yagita; Pawel Muranski; Paul A Antony; Nicholas P Restifo; James P Allison
Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts.
The Journal of experimental medicine 2010;207(3):637-50.
2010: Michael A Curran; Welby Montalvo; Hideo Yagita; James P Allison
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(9):4275-80.
2010: Emily Corse; Rachel A Gottschalk; Michelle Krogsgaard; James P Allison
Attenuated T cell responses to a high-potency ligand in vivo.
PLoS biology 2010;8(9):.
2010: Jianda Yuan; David B Page; Geoffrey Y Ku; Yanyun Li; Zhenyu Mu; Charlotte Eielson Ariyan; Humilidad F Gallardo; Ruth-Ann Roman; Agnes I Heine; Stephanie L Terzulli; Erika Ritter; Sacha Gnjatic; Gerd Ritter; Achim A Jungbluth; James P Allison; Lloyd J Old; Jedd D Wolchok
Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy.
Cancer immunity 2010;10():1.
2009: Michael Curran; James P Allison
Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors.
Cancer research 2009;69(19):7747-55.
2009: Karl S Peggs; Sergio Quezada; Cynthia A Chambers; Alan J Korman; James P Allison
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies.
The Journal of experimental medicine 2009;206(8):1717-25.
2009: Tsvetelina Pentcheva-Hoang; Emily Corse; James P Allison
Negative regulators of T-cell activation: potential targets for therapeutic intervention in cancer, autoimmune disease, and persistent infections.
Immunological reviews 2009;229(1):67-87.
2008: Sergio Quezada; Karl S Peggs; Tyler R Simpson; Yuelei Shen; Dan R Littman; James P Allison
Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma.
The Journal of experimental medicine 2008;205(9):2125-38.
2008: Brian Kavanagh; Shaun O'Brien; David Lee; Yafei Hou; Vivian Weinberg; Brian Rini; James P Allison; Eric J Small; Lawrence Fong
CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4+ T cells in a dose-dependent fashion.
Blood 2008;112(4):1175-83.
2008: R Houston Thompson; Xingxing Zang; Christine M Lohse; Bradley C Leibovich; Susan F Slovin; Victor E Reuter; John C Cheville; Michael L Blute; Paul Russo; Eugene D Kwon; James P Allison
Serum-soluble B7x is elevated in renal cell carcinoma patients and is associated with advanced stage.
Cancer research 2008;68(15):6054-8.
2008: Marcella Fassò; Rebecca Waitz; Yafei Hou; Tae Rim; Norman M Greenberg; Nilabh Shastri; Lawrence Fong; James P Allison
SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(9):3509-14.
2008: Neil H Segal; DONALD PARSONS; Karl S Peggs; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; James P Allison
Epitope landscape in breast and colorectal cancer.
Cancer research 2008;68(3):889-92.
2008: Peter A Savage; Keith Vosseller; Chulho Kang; Kevin Larimore; Elyn Riedel; Kathleen Wojnoonski; Achim A Jungbluth; James P Allison
Recognition of a ubiquitous self antigen by prostate cancer-infiltrating CD8+ T lymphocytes.
Science (New York, N.Y.) 2008;319(5860):215-20.
2007: Xingxing Zang; R Houston Thompson; Hikmat Al-Ahmadie; Angel M Serio; Victor E Reuter; James A Eastham; Peter T Scardino; Padmanee Sharma; James P Allison
B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(49):19458-63.
2007: Tsvetelina Pentcheva-Hoang; Lieping Chen; Drew M Pardoll; James P Allison
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17765-70.
2007: Xingxing Zang; James P Allison
The B7 family and cancer therapy: costimulation and coinhibition.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(18 Pt 1):5271-9.
2007: P'ng Loke; Iain Gallagher; Meera G Nair; Xingxing Zang; Frank Brombacher; Markus Mohrs; James P Allison; Judith E Allen
Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(6):3926-36.
2007: Erhu Cao; Xingxing Zang; Udupi A Ramagopal; Arunika Mukhopadhaya; Alexander A Fedorov; Elena V Fedorov; Wendy D Zencheck; Jeffrey W Lary; James L Cole; Haiteng Deng; Hui Xiao; Teresa P DiLorenzo; James P Allison; Stanley G Nathenson; Steven C Almo
T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface.
Immunity 2007;26(3):311-21.
2006: Xingxing Zang; P'ng Loke; Jayon Kim; Kathleen Wojnoonski; Leonard Kusdra; James P Allison
A genetic library screen for signaling proteins that interact with phosphorylated T cell costimulatory receptors.
Genomics 2006;88(6):841-5.
2006: Xingxing Zang; James P Allison
To be or not to be B7.
The Journal of clinical investigation 2006;116(10):2590-3.
2006: John J Engelhardt; Timothy J Sullivan; James P Allison
CTLA-4 overexpression inhibits T cell responses through a CD28-B7-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1052-61.
2006: Sergio Quezada; Karl S Peggs; Michael Curran; James P Allison
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells.
The Journal of clinical investigation 2006;116(7):1935-45.
2006: Karl S Peggs; Sergio Quezada; Alan J Korman; James P Allison
Principles and use of anti-CTLA4 antibody in human cancer immunotherapy.
Current opinion in immunology 2006;18(2):206-13.
2006: Alan J Korman; Karl S Peggs; James P Allison
Checkpoint blockade in cancer immunotherapy.
Advances in immunology 2006;90():297-339.
2005: Joy A Williams; Karen S Hathcock; David Klug; Yohsuke Harada; Baishakhi Choudhury; James P Allison; Ryo Abe; Richard J Hodes
Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(7):4199-207.
2005: Karl S Peggs; James P Allison
Co-stimulatory pathways in lymphocyte regulation: the immunoglobulin superfamily.
British journal of haematology 2005;130(6):809-24.
2005: P'ng Loke; Xingxing Zang; Lisa Hsuan; Rebecca Waitz; Richard M Locksley; Judith E Allen; James P Allison
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9872-7.
2005: Lauren I Richie Ehrlich; Kouetsu Ogasawara; Jessica A Hamerman; Rayna Takaki; Alessandra Zingoni; James P Allison; Lewis L Lanier
Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(4):1922-31.
2004: Anja C Roden; Michael T Moser; Samuel D Tri; Maria Mercader; Susan M Kuntz; Haidong Dong; Arthur A Hurwitz; David J McKean; Esteban Celis; Bradley C Leibovich; James P Allison; Eugene D Kwon
Augmentation of T cell levels and responses induced by androgen deprivation.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6098-108.
2004: Tsvetelina Pentcheva-Hoang; Jackson G Egen; Kathleen Wojnoonski; James P Allison
B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse.
Immunity 2004;21(3):401-13.
2004: Mizuko Mamura; WoonKyu Lee; Timothy J Sullivan; Angelina Felici; Anastasia L Sowers; James P Allison; John J Letterio
CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1.
Blood 2004;103(12):4594-601.
2004: Polly D Gregor; Jedd D Wolchok; Cristina R Ferrone; Heidi Buchinshky; Jose A. Guevara-Patino; Miguel-Angel Perales; Fariborz Mortazavi; Dean J Bacich; Warren D W Heston; Jean-Baptiste Latouche; Michel Sadelain; James P Allison; Howard I Scher; Alan N Houghton
CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems.
Vaccine 2004;22(13-14):1700-8.
2004: P'ng Loke; James P Allison
Emerging mechanisms of immune regulation: the extended B7 family and regulatory T cells.
Arthritis research & therapy 2004;6(5):208-14.
2003: Xingxing Zang; P'ng Loke; Jayon Kim; Kenneth Murphy; Rebecca Waitz; James P Allison
B7x: a widely expressed B7 family member that inhibits T cell activation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10388-92.
2003: Giao Q Phan; James C Yang; Richard M Sherry; Patrick Hwu; Suzanne Topalian; Douglas J Schwartzentruber; Nicholas P Restifo; Leah R Haworth; Claudia A Seipp; Linda J Freezer; Kathleen E Morton; Sharon A Mavroukakis; Paul H Duray; Seth M Steinberg; James P Allison; Thomas A Davis; STEVEN ROSENBERG
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8372-7.
2003: Norihiko Watanabe; Maya Gavrieli; John R Sedy; Jianfei Yang; Francesca Fallarino; Susan K Loftin; Michelle A Hurchla; Natalie Zimmerman; Julia Sim; Xingxing Zang; Theresa L Murphy; John H Russell; James P Allison; Kenneth M Murphy
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.
Nature immunology 2003;4(7):670-9.
2003: P'ng Loke; James P Allison
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5336-41.
2003: Arthur A Hurwitz; Paul Yanover; Mary Markowitz; James P Allison; Eugene D Kwon
Prostate cancer: advances in immunotherapy.
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 2003;17(2):131-8.
2002: Jackson G Egen; Michael S Kuhns; James P Allison
CTLA-4: new insights into its biological function and use in tumor immunotherapy.
Nature immunology 2002;3(7):611-8.
2002: Cynthia A Chambers; Joonsoo Kang; Yongjian Wu; Werner Held; David H Raulet; James P Allison
The lymphoproliferative defect in CTLA-4-deficient mice is ameliorated by an inhibitory NK cell receptor.
Blood 2002;99(12):4509-16.
2002: Arthur A Hurwitz; Timothy J Sullivan; Raymond A Sobel; James P Allison
Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):3013-7.
2002: Jackson G Egen; James P Allison
Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength.
Immunity 2002;16(1):23-35.
2001: Roger P M Sutmuller; Leonie van Duivenvoorde; A van Elsas; Schumacher Ton; M E Wildenberg; James P Allison; René E M Toes; Rienk Offringa; Cornelis J M Melief
Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses.
The Journal of experimental medicine 2001;194(6):823-32.
2001: A van Elsas; Roger P M Sutmuller; Arthur A Hurwitz; J Ziskin; J Villasenor; Jan Paul Medema; W W Overwijk; N P Restifo; Cornelis J M Melief; Rienk Offringa; James P Allison
Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy.
The Journal of experimental medicine 2001;194(4):481-9.
2001: Timothy J Sullivan; John J Letterio; A van Elsas; Mizuko Mamura; J van Amelsfort; S Sharpe; B Metzler; Cynthia A Chambers; James P Allison
Lack of a role for transforming growth factor-beta in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2587-92.
2001: Cynthia A Chambers; Michael S Kuhns; Jackson G Egen; James P Allison
CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy.
Annual review of immunology 2001;19():565-94.
2000: Michael S Kuhns; V Epshteyn; Raymond A Sobel; James P Allison
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+ T cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12711-6.
2000: F Luhder; C Chambers; James P Allison; Christophe Benoist; Diane Mathis
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(22):12204-9.
2000: Arthur A Hurwitz; Barbara A Foster; Eugene D Kwon; T Truong; E M Choi; Norman M Greenberg; MAURICE BURG; James P Allison
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.
Cancer research 2000;60(9):2444-8.
2000: Xin Yu; S Fournier; James P Allison; Arlene H Sharpe; Richard J Hodes
The role of B7 costimulation in CD4/CD8 T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(7):3543-53.
1999: Eugene D Kwon; Barbara A Foster; Arthur A Hurwitz; C Madias; James P Allison; Norman M Greenberg; MAURICE BURG
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15074-9.
1999: A van Elsas; Arthur A Hurwitz; James P Allison
Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation.
The Journal of experimental medicine 1999;190(3):355-66.
1999: Cynthia A Chambers; Michael S Kuhns; James P Allison
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8603-8.
1999: M C Brunner; Cynthia A Chambers; FK Chan; J Hanke; Astar Winoto; James P Allison
CTLA-4-Mediated inhibition of early events of T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(10):5813-20.
1999: Cynthia A Chambers; James P Allison
Costimulatory regulation of T cell function.
Current opinion in cell biology 1999;11(2):203-10.
1999: Cynthia A Chambers; James P Allison
CTLA-4--the costimulatory molecule that doesn't: regulation of T-cell responses by inhibition.
Cold Spring Harbor symposia on quantitative biology 1999;64():303-12.
1998: Cynthia A Chambers; Timothy J Sullivan; T Truong; James P Allison
Secondary but not primary T cell responses are enhanced in CTLA-4-deficient CD8+ T cells.
European journal of immunology 1998;28(10):3137-43.
1998: Arthur A Hurwitz; T F Yu; D R Leach; James P Allison
CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(17):10067-71.
1998: Jeffrey C Rathmell; S Fournier; B C Weintraub; James P Allison; Christopher C Goodnow
Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cells.
The Journal of experimental medicine 1998;188(4):651-9.
1998: Arthur A Hurwitz; S E Townsend; T F Yu; J A Wallin; James P Allison
Enhancement of the anti-tumor immune response using a combination of interferon-gamma and B7 expression in an experimental mammary carcinoma.
International journal of cancer. Journal international du cancer 1998;77(1):107-13.
1998: F Lühder; P Höglund; James P Allison; Christophe Benoist; Diane Mathis
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes.
The Journal of experimental medicine 1998;187(3):427-32.
1998: James P Allison; C Chambers; Arthur A Hurwitz; T Sullivan; B Boitel; S Fournier; M Brunner; Matthew F Krummel
A role for CTLA-4-mediated inhibitory signals in peripheral T cell tolerance?
Novartis Foundation symposium 1998;215():92-8; discussion 98-102, 186-90.
1997: Cynthia A Chambers; Timothy J Sullivan; James P Allison
Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells.
Immunity 1997;7(6):885-95.
1997: Cynthia A Chambers; D Cado; T Truong; James P Allison
Thymocyte development is normal in CTLA-4-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9296-301.
1997: Yuelin Zhang; James P Allison
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(17):9273-8.
1997: Eugene D Kwon; Arthur A Hurwitz; Barbara A Foster; C Madias; A L Feldhaus; Norman M Greenberg; MAURICE BURG; James P Allison
Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):8099-103.
1997: X C Liao; S Fournier; Nigel Killeen; Arthur Weiss; James P Allison; Dan R Littman
Itk negatively regulates induction of T cell proliferation by CD28 costimulation.
The Journal of experimental medicine 1997;186(2):221-8.
1997: Cynthia A Chambers; James P Allison
Co-stimulation in T cell responses.
Current opinion in immunology 1997;9(3):396-404.
1997: S Fournier; Jeffrey C Rathmell; C C Goodnow; James P Allison
T cell-mediated elimination of B7.2 transgenic B cells.
Immunity 1997;6(3):327-39.
1997: Arthur A Hurwitz; Timothy J Sullivan; Matthew F Krummel; Raymond A Sobel; James P Allison
Specific blockade of CTLA-4/B7 interactions results in exacerbated clinical and histologic disease in an actively-induced model of experimental allergic encephalomyelitis.
Journal of neuroimmunology 1997;73(1-2):57-62.
1996: Cynthia A Chambers; James P Allison
The role of tyrosine phosphorylation and PTP-1C in CTLA-4 signal transduction.
European journal of immunology 1996;26(12):3224-9.
1996: Cynthia A Chambers; Matthew F Krummel; B Boitel; Arthur A Hurwitz; Timothy J Sullivan; S Fournier; D Cassell; M Brunner; James P Allison
The role of CTLA-4 in the regulation and initiation of T-cell responses.
Immunological reviews 1996;153():27-46.
1996: Matthew F Krummel; James P Allison
CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.
The Journal of experimental medicine 1996;183(6):2533-40.
1996: Matthew F Krummel; Timothy J Sullivan; James P Allison
Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo.
International immunology 1996;8(4):519-23.
1996: D R Leach; Matthew F Krummel; James P Allison
Enhancement of antitumor immunity by CTLA-4 blockade.
Science (New York, N.Y.) 1996;271(5256):1734-6.
1996: B Liu; Eckhard R Podack; James P Allison; Thomas R Malek
Generation of primary tumor-specific CTL in vitro to immunogenic and poorly immunogenic mouse tumors.
Journal of immunology (Baltimore, Md. : 1950) 1996;156(3):1117-25.
1995: James P Allison; Matthew F Krummel
The Yin and Yang of T cell costimulation.
Science (New York, N.Y.) 1995;270(5238):932-3.
1995: James P Allison; Arthur A Hurwitz; D R Leach
Manipulation of costimulatory signals to enhance antitumor T-cell responses.
Current opinion in immunology 1995;7(5):682-6.
1995: Y Zhang; Dragana Cado; D M Asarnow; T Komori; F W Alt; David H Raulet; James P Allison
The role of short homology repeats and TdT in generation of the invariant gamma delta antigen receptor repertoire in the fetal thymus.
Immunity 1995;3(4):439-47.
1995: Matthew F Krummel; James P Allison
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
The Journal of experimental medicine 1995;182(2):459-65.
1994: S E Townsend; F W Su; J M Atherton; James P Allison
Specificity and longevity of antitumor immune responses induced by B7-transfected tumors.
Cancer research 1994;54(24):6477-83.
1994: James P Allison
CD28-B7 interactions in T-cell activation.
Current opinion in immunology 1994;6(3):414-9.
1994: D Nandi; J A Gross; James P Allison
CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(7):3361-9.
1994: M A Holsti; J McArthur; James P Allison; David H Raulet
Role of IL-6, IL-1, and CD28 signaling in responses of mouse CD4+ T cells to immobilized anti-TCR monoclonal antibody.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(4):1618-28.
1993: D Nandi; James P Allison
Characterization of neutrophils and T lymphocytes associated with the murine vaginal epithelium.
Regional immunology 1993;5(6):332-8.
1993: Charles G. Sagerstrom; E M Kerr; James P Allison; Mark M Davis
Activation and differentiation requirements of primary T cells in vitro.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):8987-91.
1993: F A Harding; James P Allison
CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.
The Journal of experimental medicine 1993;177(6):1791-6.
1993: James P Allison
Gamma delta T-cell development.
Current opinion in immunology 1993;5(2):241-6.
1993: R A Gramzinski; E Adams; J A Gross; T G Goodman; James P Allison; L Lefrançois
T cell receptor-triggered activation of intraepithelial lymphocytes in vitro.
International immunology 1993;5(2):145-53.
1993: S E Townsend; James P Allison
Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells.
Science (New York, N.Y.) 1993;259(5093):368-70.
1992: J A Gross; E Callas; James P Allison
Identification and distribution of the costimulatory receptor CD28 in the mouse.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(2):380-8.
1992: F A Harding; J G McArthur; J A Gross; David H Raulet; James P Allison
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones.
Nature 1992;356(6370):607-9.
1991: D Nandi; James P Allison
Phenotypic analysis and gamma delta-T cell receptor repertoire of murine T cells associated with the vaginal epithelium.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(6):1773-8.
1991: W L Havran; Y H Chien; James P Allison
Recognition of self antigens by skin-derived T cells with invariant gamma delta antigen receptors.
Science (New York, N.Y.) 1991;252(5011):1430-2.
1991: M Iwashima; A Green; ML Bonyhadi; Mark M Davis; James P Allison; Yueh-hsiu Chien
Expression of a fetal gamma delta T-cell receptor in adult mice triggers a non-MHC-linked form of selective depletion.
International immunology 1991;3(4):385-93.
1991: N Glaichenhaus; C Davis; K Bornschlegel; James P Allison; Nilabh Shastri
A novel strategy for the generation of T cell lines lacking expression of endogenous alpha- and/or beta-chain T cell receptor genes.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2095-101.
1991: W L Havran; A Carbone; James P Allison
Murine T cells with invariant gamma delta antigen receptors: origin, repertoire, and specificity.
Seminars in immunology 1991;3(2):89-97.
1991: James P Allison; D M Asarnow; M Bonyhadi; A Carbone; W L Havran; D Nandi; J Noble
Gamma delta T cells in murine epithelia: origin, repertoire, and function.
Advances in experimental medicine and biology 1991;292():63-9.
1991: James P Allison; W L Havran
The immunobiology of T cells with invariant gamma delta antigen receptors.
Annual review of immunology 1991;9():679-705.
1990: J S Riegel; E R Richie; James P Allison
Nuclear events after activation of CD4+8+ thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(9):3611-8.
1990: J A Gross; T St John; James P Allison
The murine homologue of the T lymphocyte antigen CD28. Molecular cloning and cell surface expression.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(8):3201-10.
1990: W L Havran; James P Allison
Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors.
Nature 1990;344(6261):68-70.
1990: James P Allison; David H Raulet
The immunobiology of gamma delta+ T cells.
Seminars in immunology 1990;2(1):59-65.
1989: D M Asarnow; T Goodman; L LeFrancois; James P Allison
Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells.
Nature 1989;341(6237):60-2.
1989: Samuel Strober; S Dejbachsh-Jones; P Van Vlasselaer; G Duwe; S Salimi; James P Allison
Cloned natural suppressor cell lines express the CD3+CD4-CD8- surface phenotype and the alpha, beta heterodimer of the T cell antigen receptor.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(4):1118-22.
1989: W L Havran; S Grell; G Duwe; J Kimura; A Wilson; A M Kruisbeek; Rebecca L O'Brien; Willi K Born; R E Tigelaar; James P Allison
Limited diversity of T-cell receptor gamma-chain expression of murine Thy-1+ dendritic epidermal cells revealed by V gamma 3-specific monoclonal antibody.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4185-9.
1989: P Duplay; D Lancki; James P Allison
Distribution and ontogeny of CD2 expression by murine T cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(9):2998-3005.
1989: W L Havran; M Poenie; R E Tigelaar; Roger Y Tsien; James P Allison
Phenotypic and functional analysis of gamma delta T cell receptor-positive murine dendritic epidermal clones.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(5):1422-8.
1988: D M Asarnow; William Kuziel; M Bonyhadi; R E Tigelaar; Philip W Tucker; James P Allison
Limited diversity of gamma delta antigen receptor genes of Thy-1+ dendritic epidermal cells.
Cell 1988;55(5):837-47.
1988: W L Havran; James P Allison
Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors.
Nature 1988;335(6189):443-5.
1988: James P Allison; W L Havran; D Asarnow; R E Tigelaar; Philip W Tucker; M Bonyhadi
Gamma delta antigen receptors of Thy-1+ dendritic epidermal cells: implications for thymic differentiation.
Immunologic research 1988;7(4):292-302.
1987: M Bonyhadi; A Weiss; Philip W Tucker; R E Tigelaar; James P Allison
Delta is the Cx-gene product in the gamma/delta antigen receptor of dendritic epidermal cells.
Nature 1987;330(6148):574-6.
1987: W L Havran; M Poenie; J Kimura; Roger Y Tsien; A Weiss; James P Allison
Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes.
Nature 1987;330(6144):170-3.
1987: William Kuziel; Akira Takashima; M Bonyhadi; Paul R Bergstresser; James P Allison; R E Tigelaar; Philip W Tucker
Regulation of T-cell receptor gamma-chain RNA expression in murine Thy-1+ dendritic epidermal cells.
Nature 1987;328(6127):263-6.