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David Covell

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Susan D Mertins; Anne Monks; David S Salomon; Dominic A Scudiero; Michael C Alley; David G Covell; Raymond D Divelbiss; Karen Hite; Melinda G Hollingshead; John E Niederhuber
A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept.
David G Covell; Susan Kenney; Anders Wallqvist; David T Vistica
Bioinformatic analysis of patient-derived ASPS gene expressions and ASPL-TFE3 fusion transcript levels identify potential therapeutic targets.
David G Covell; Ruili Huang; Anders Wallqvist
Anticancer medicines in development: assessment of bioactivity profiles within the National Cancer Institute anticancer screening data.

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All Publications

2013: Susan D Mertins; Anne Monks; David S Salomon; Dominic A Scudiero; Michael C Alley; David G Covell; Raymond D Divelbiss; Karen Hite; Melinda G Hollingshead; John E Niederhuber
A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept.
PloS one 2013;8(2):e57099.
2012: David G Covell; Susan Kenney; Anders Wallqvist; David T Vistica
Bioinformatic analysis of patient-derived ASPS gene expressions and ASPL-TFE3 fusion transcript levels identify potential therapeutic targets.
PloS one 2012;7(11):e48023.
2007: David G Covell; Ruili Huang; Anders Wallqvist
Anticancer medicines in development: assessment of bioactivity profiles within the National Cancer Institute anticancer screening data.
Molecular cancer therapeutics 2007;6(8):2261-70.
2007: Anders Wallqvist; Ruili Huang; David G Covell
Chemoinformatic analysis of NCI preclinical tumor data: evaluating compound efficacy from mouse xenograft data, NCI-60 screening data, and compound descriptors.
Journal of chemical information and modeling 2007;47(4):1414-27.
2007: Constance J Glover; Alfred A Rabow; yasemin G isgor; Robert H Shoemaker; David G Covell
Data mining of NCI's anticancer screening database reveals mitochondrial complex I inhibitors cytotoxic to leukemia cell lines.
Biochemical pharmacology 2007;73(3):331-40.
2006: Ruili Huang; Anders Wallqvist; David G Covell
Targeting changes in cancer: assessing pathway stability by comparing pathway gene expression coherence levels in tumor and normal tissues.
Molecular cancer therapeutics 2006;5(9):2417-27.
2006: Ruili Huang; Anders Wallqvist; David G Covell
Assessment of in vitro and in vivo activities in the National Cancer Institute's anticancer screen with respect to chemical structure, target specificity, and mechanism of action.
Journal of medicinal chemistry 2006;49(6):1964-79.
2006: Ruili Huang; Anders Wallqvist; David G Covell
Comprehensive analysis of pathway or functionally related gene expression in the National Cancer Institute's anticancer screen.
Genomics 2006;87(3):315-28.
2006: Anders Wallqvist; John Connelly; Edward A Sausville; David G Covell; Anne Monks
Differential gene expression as a potential classifier of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole-sensitive and -insensitive cell lines.
Molecular pharmacology 2006;69(3):737-48.
2006: Anders Wallqvist; Ruili Huang; Narmada Thanki; David G Covell
Evaluating chemical structure similarity as an indicator of cellular growth inhibition.
Journal of chemical information and modeling 2006;46(1):430-7.
2005: Anders Wallqvist; Ruili Huang; David G Covell; Anna V Roschke; Kristen S Gelhaus; Ilan R Kirsch
Drugs aimed at targeting characteristic karyotypic phenotypes of cancer cells.
Molecular cancer therapeutics 2005;4(10):1559-68.
2005: David G Covell; Anders Wallqvist; Ruili Huang; Narmada Thanki; Alfred A Rabow; Xiang-Jun Lu
Linking tumor cell cytotoxicity to mechanism of drug action: an integrated analysis of gene expression, small-molecule screening and structural databases.
Proteins 2005;59(3):403-33.
2005: Ruili Huang; Anders Wallqvist; David G Covell
Anticancer metal compounds in NCI's tumor-screening database: putative mode of action.
Biochemical pharmacology 2005;69(7):1009-39.
2005: Gabriela Tudor; Mike Alley; Christopher M Nelson; Ruili Huang; David G Covell; Peter L Gutierrez; Edward A Sausville
Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction.
Anti-cancer drugs 2005;16(4):381-91.
2005: R Huang; Anders Wallqvist; Narmada Thanki; David G Covell
Linking pathway gene expressions to the growth inhibition response from the National Cancer Institute's anticancer screen and drug mechanism of action.
The pharmacogenomics journal 2005;5(6):381-99.
2004: Ruoli Bai; David G Covell; George F Taylor; John A Kepler; Terry D Copeland; Nga Y Nguyen; George R Pettit; Ernest Hamel
Direct photoaffinity labeling by dolastatin 10 of the amino-terminal peptide of beta-tubulin containing cysteine 12.
The Journal of biological chemistry 2004;279(29):30731-40.
2003: Anders Wallqvist; Alfred A Rabow; Robert H Shoemaker; Edward A Sausville; David G Covell
Linking the growth inhibition response from the National Cancer Institute's anticancer screen to gene expression levels and other molecular target data.
Bioinformatics (Oxford, England) 2003;19(17):2212-24.
2003: David G Covell; Anders Wallqvist; Alfred A Rabow; Narmada Thanki
Molecular classification of cancer: unsupervised self-organizing map analysis of gene expression microarray data.
Molecular cancer therapeutics 2003;2(3):317-32.
2003: Anders Wallqvist; Anne Monks; Alfred A Rabow; Narmada Thanki; Robert H Shoemaker; David G Covell
Mining the NCI screening database: explorations of agents involved in cell cycle regulation.
Progress in cell cycle research 2003;5():173-9.
2002: ozlem keskin; X Ji; J Blaszcyk; David G Covell
Molecular motions and conformational changes of HPPK.
Proteins 2002;49(2):191-205.
2002: Andrew G Stephen; Karen M Worthy; Eric Towler; Judy A Mikovits; Shizuko Sei; Paula Roberts; Quan-en Yang; Rhone Akee; Paul Klausmeyer; Thomas G McCloud; Lou Henderson; Alan Rein; David G Covell; Michael J Currens; Robert H Shoemaker; Robert J Fisher
Identification of HIV-1 nucleocapsid protein: nucleic acid antagonists with cellular anti-HIV activity.
Biochemical and biophysical research communications 2002;296(5):1228-37.
2002: Ruoli Bai; David G Covell; Chunfeng Liu; Arun K Ghosh; Ernest Hamel
(-)-Doliculide, a new macrocyclic depsipeptide enhancer of actin assembly.
The Journal of biological chemistry 2002;277(35):32165-71.
2002: ozlem keskin; Stewart R Durell; Ivet Bahar; Robert L Jernigan; David G Covell
Relating molecular flexibility to function: a case study of tubulin.
Biophysical journal 2002;83(2):663-80.
2002: Anders Wallqvist; Alfred A Rabow; Robert H Shoemaker; Edward A Sausville; David G Covell
Establishing connections between microarray expression data and chemotherapeutic cancer pharmacology.
Molecular cancer therapeutics 2002;1(5):311-20.
2002: Robert H Shoemaker; Dominic A Scudiero; Giovanni Melillo; Michael J Currens; Anne P Monks; Alfred A Rabow; David G Covell; Edward A Sausville
Application of high-throughput, molecular-targeted screening to anticancer drug discovery.
Current topics in medicinal chemistry 2002;2(3):229-46.
2002: Alfred A Rabow; Robert H Shoemaker; Edward A Sausville; David G Covell
Mining the National Cancer Institute's tumor-screening database: identification of compounds with similar cellular activities.
Journal of medicinal chemistry 2002;45(4):818-40.
2002: ozlem keskin; Ivet Bahar; D Flatow; David G Covell; Robert L Jernigan
Molecular mechanisms of chaperonin GroEL-GroES function.
Biochemistry 2002;41(2):491-501.
2002: Ernest Hamel; David G Covell
Antimitotic peptides and depsipeptides.
Current medicinal chemistry. Anti-cancer agents 2002;2(1):19-53.
2001: A T Maynard; David G Covell
Reactivity of zinc finger cores: analysis of protein packing and electrostatic screening.
Journal of the American Chemical Society 2001;123(6):1047-58.
2000: Ruoli Bai; David G Covell; X F Pei; JB Ewell; Nga Y Nguyen; Arnold Brossi; Ernest Hamel
Mapping the binding site of colchicinoids on beta -tubulin. 2-Chloroacetyl-2-demethylthiocolchicine covalently reacts predominantly with cysteine 239 and secondarily with cysteine 354.
The Journal of biological chemistry 2000;275(51):40443-52.
1999: Anders Wallqvist; T A Lavoie; J A Chanatry; David G Covell; J Carey
Cooperative folding units of escherichia coli tryptophan repressor.
Biophysical journal 1999;77(3):1619-26.
1999: Jim A Turpin; Y Song; John K Inman; M Huang; Anders Wallqvist; A Maynard; David G Covell; William G Rice; Ettore Appella
Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers.
Journal of medicinal chemistry 1999;42(1):67-86.
1998: Anders Wallqvist; G W Smythers; David G Covell
A cooperative folding unit in HIV-1 protease. Implications for protein stability and occurrence of drug-induced mutations.
Protein engineering 1998;11(11):999-1005.
1998: Anna Blom; David G Covell; Anders Wallqvist; Björn Dahlbäck; Bruno Villoutreix
The C4b-binding protein-protein S interaction is hydrophobic in nature.
Biochimica et biophysica acta 1998;1388(1):181-9.
1998: A T Maynard; M Huang; W G Rice; David G Covell
Reactivity of the HIV-1 nucleocapsid protein p7 zinc finger domains from the perspective of density-functional theory.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):11578-83.
1998: Bruno Villoutreix; Y Härdig; Anders Wallqvist; David G Covell; Pablo García de Frutos; Björn Dahlbäck
Structural investigation of C4b-binding protein by molecular modeling: localization of putative binding sites.
Proteins 1998;31(4):391-405.
1998: M Huang; A Maynard; Jim A Turpin; L Graham; G M Janini; David G Covell; William G Rice
Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins.
Journal of medicinal chemistry 1998;41(9):1371-81.
1998: Ivet Bahar; Anders Wallqvist; David G Covell; Robert L Jernigan
Correlation between native-state hydrogen exchange and cooperative residue fluctuations from a simple model.
Biochemistry 1998;37(4):1067-75.
1997: Anders Wallqvist; G W Smythers; David G Covell
Identification of cooperative folding units in a set of native proteins.
Protein science : a publication of the Protein Society 1997;6(8):1627-42.
1997: David G Covell; Anders Wallqvist
Analysis of protein-protein interactions and the effects of amino acid mutations on their energetics. The importance of water molecules in the binding epitope.
Journal of molecular biology 1997;269(2):281-97.
1997: William G Rice; Jim A Turpin; M Huang; DJ Clanton; Robert W Buckheit; David G Covell; Anders Wallqvist; N B McDonnell; R N DeGuzman; Michael F Summers; L Zalkow; JP Bader; R D Haugwitz; Edward A Sausville
Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein.
Nature medicine 1997;3(3):341-5.
1996: William G Rice; Jim A Turpin; CA Schaeffer; L Graham; D Clanton; Robert W Buckheit; Daniel W Zaharevitz; Michael F Summers; Anders Wallqvist; David G Covell
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
Journal of medicinal chemistry 1996;39(19):3606-16.
1996: Anders Wallqvist; David G Covell
Docking enzyme-inhibitor complexes using a preference-based free-energy surface.
Proteins 1996;25(4):403-19.
1996: Anders Wallqvist; David G Covell
On the origins of the hydrophobic effect: observations from simulations of n-dodecane in model solvents.
Biophysical journal 1996;71(2):600-8.
1995: Anders Wallqvist; Robert L Jernigan; David G Covell
A preference-based free-energy parameterization of enzyme-inhibitor binding. Applications to HIV-1-protease inhibitor design.
Protein science : a publication of the Protein Society 1995;4(9):1881-903.
1994: David G Covell; G W Smythers; A M Gronenborn; G M Clore
Analysis of hydrophobicity in the alpha and beta chemokine families and its relevance to dimerization.
Protein science : a publication of the Protein Society 1994;3(11):2064-72.
1994: L Young; Robert L Jernigan; David G Covell
A role for surface hydrophobicity in protein-protein recognition.
Protein science : a publication of the Protein Society 1994;3(5):717-29.
1992: David G Covell
Folding protein alpha-carbon chains into compact forms by Monte Carlo methods.
Proteins 1992;14(3):409-20.