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Douglas Covey

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James W Simpkins; Kun Don Yi; Evelyn Perez; Timothy E Richardson; Douglas F Covey
Neuroprotection with non-feminizing estrogen analogues: an overlooked possible therapeutic strategy.
Charles F Zorumski; Steven M Paul; Douglas F Covey; Yukitoshi Izumi; Steven Mennerick
Neurosteroids, stress and depression: potential therapeutic opportunities.
Zi-Wei Chen; Douglas F Covey; Karoline Fuchs; Brad Manion; David E Reichert; Werner Sieghart; Joe Henry Steinbach; R Reid Townsend; Alex S Evers
Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor.

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All Publications

2013: James W Simpkins; Kun Don Yi; Evelyn Perez; Timothy E Richardson; Douglas F Covey
Neuroprotection with non-feminizing estrogen analogues: an overlooked possible therapeutic strategy.
Hormones and behavior 2013;63(2):278-83.
2013: Charles F Zorumski; Steven M Paul; Douglas F Covey; Yukitoshi Izumi; Steven Mennerick
Neurosteroids, stress and depression: potential therapeutic opportunities.
Neuroscience and biobehavioral reviews 2013;37(1):109-22.
2012: Zi-Wei Chen; Douglas F Covey; Karoline Fuchs; Brad Manion; David E Reichert; Werner Sieghart; Joe Henry Steinbach; R Reid Townsend; Alex S Evers
Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor.
Molecular pharmacology 2012;82(3):408-19.
2012: Hong-Jin Shu; Joe Henry Steinbach; Amanda Taylor; Kyle Wu; Charles F Zorumski; Gustav Akk; John R Bracamontes; Douglas F Covey; Megan M Eaton; Alex S Evers; Kathiresan Krishnan; Brad Manion; Steven Mennerick
Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes.
British journal of pharmacology 2012;165(7):2228-43.
2012: Agata A Bielska; Douglas F Covey; Paul Schlesinger; Daniel S Ory
Oxysterols as non-genomic regulators of cholesterol homeostasis.
Trends in endocrinology and metabolism: TEM 2012;23(3):99-106.
2012: Kathiresan Krishnan; Brad D Manion; Steven Mennerick; David E Reichert; Joe Henry Steinbach; Amanda Taylor; Charles F Zorumski; John R Bracamontes; Alex S Evers; Douglas F Covey
Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors.
Journal of medicinal chemistry 2012;55(3):1334-45.
2012: Zi-Wei Chen; Douglas F Covey; Ramin Darbandi; Randy Hastings; Cheryl F Lichti; David E Reichert; R Reid Townsend; Natalia Akentieva; Li-Hai Chen; Alex S Evers
A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis.
Electrophoresis 2012;33(4):666-74.
2011: Nina Sneitz; Kathiresan Krishnan; Douglas F Covey; Moshe Finel
Glucuronidation of the steroid enantiomers ent-17β-estradiol, ent-androsterone and ent-etiocholanolone by the human UDP-glucuronosyltransferases.
The Journal of steroid biochemistry and molecular biology 2011;127(3-5):282-8.
2011: Agata A Bielska; Daniel S Ory; Douglas F Covey
Synthesis of the enantiomer of the oxysterol-antagonist LY295427.
Steroids 2011;76(10-11):986-90.
2011: Eva Stastna; Nigam P Rath; Douglas F Covey
The use of symmetry in enantioselective synthesis: four pairs of chrysene enantiomers prepared from 19-nortestosterone.
Organic & biomolecular chemistry 2011;9(12):4685-94.
2011: Eva Stastna; Kathiresan Krishnan; Brad D Manion; Amanda Taylor; Nigam P Rath; Zi-Wei Chen; Alex S Evers; Charles F Zorumski; Steven Mennerick; Douglas F Covey
Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity.
Journal of medicinal chemistry 2011;54(11):3926-34.
2011: Kun Don YI; Evelyn Perez; Shaohua Yang; Ran Liu; Douglas F Covey; James W Simpkins
The assessment of non-feminizing estrogens for use in neuroprotection.
Brain research 2011;1379():61-70.
2011: Nazzareno D'Avanzo; Krzysztof Hyrc; Decha Enkvetchakul; Douglas F Covey; Colin G Nichols
Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier K+ channels by cholesterol.
PloS one 2011;6(4):e19393.
2010: Achintya K Bandyopadhyaya; Brad D Manion; Ann Benz; Amanda Taylor; Nigam P Rath; Alex S Evers; Charles F Zorumski; Steven Mennerick; Douglas F Covey
Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues.
Bioorganic & medicinal chemistry letters 2010;20(22):6680-4.
2010: Mariangela Chisari; Lawrence N Eisenman; Douglas F Covey; Steven Mennerick; Charles F Zorumski
The sticky issue of neurosteroids and GABA(A) receptors.
Trends in neurosciences 2010;33(7):299-306.
2010: Alex S Evers; Zi-Wei Chen; Brad D Manion; Mingcheng Han; Xin Jiang; Ramin Darbandi-Tonkabon; Tristan Kable; John R Bracamontes; Charles F Zorumski; Steven Mennerick; Joe Henry Steinbach; Douglas F Covey
A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors.
The Journal of pharmacology and experimental therapeutics 2010;333(2):404-13.
2010: Gustav Akk; Douglas F Covey; Alex S Evers; Steven Mennerick; Charles F Zorumski; Joe Henry Steinbach
Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids.
Current neuropharmacology 2010;8(1):18-25.
2009: Vesna Jevtovic-Todorovic; Douglas F Covey; Slobodan M Todorovic
Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain?
Psychoneuroendocrinology 2009;34 Suppl 1():S178-85.
2009: Gustav Akk; Douglas F Covey; Alex S Evers; Joe Henry Steinbach; Charles F Zorumski; Steven Mennerick
The influence of the membrane on neurosteroid actions at GABA(A) receptors.
Psychoneuroendocrinology 2009;34 Suppl 1():S59-66.
2009: Ping Li; Achintya K Bandyopadhyaya; Douglas F Covey; Joe Henry Steinbach; Gustav Akk
Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation.
British journal of pharmacology 2009;158(5):1322-9.
2009: Janelle R Latham; Sriyani Pathirathna; Miljen M Jagodic; Won Joo Choe; Michaela E Levin; Michael T Nelson; Woo Yong Lee; Kathiresan Krishnan; Douglas F Covey; Slobodan M Todorovic; Vesna Jevtovic-Todorovic
Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice.
Diabetes 2009;58(11):2656-65.
2009: Hong-Jin Shu; Lawrence N Eisenman; Cunde Wang; Achintya K Bandyopadhyaya; Kathiresan Krishnan; Amanda Taylor; Ann Benz; Brad Manion; Alex S Evers; Douglas F Covey; Charles F Zorumski; Steven Mennerick
Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors.
Molecular pharmacology 2009;76(4):754-65.
2009: Mariangela Chisari; Lawrence N Eisenman; Kathiresan Krishnan; Achintya K Bandyopadhyaya; Cunde Wang; Amanda Taylor; Ann Benz; Douglas F Covey; Charles F Zorumski; Steven Mennerick
The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction.
Journal of neurophysiology 2009;102(2):1254-64.
2009: Lawrence N Eisenman; Hong-Jin Shu; Cunde Wang; Elias Aizenman; Douglas F Covey; Charles F Zorumski; Steven Mennerick
NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue.
The Journal of physiology 2009;587(Pt 12):2937-47.
2009: Xiaochun Jin; Douglas F Covey; Joe Henry Steinbach
Kinetic analysis of voltage-dependent potentiation and block of the glycine alpha 3 receptor by a neuroactive steroid analogue.
The Journal of physiology 2009;587(Pt 5):981-97.
2009: Kun Don YI; Douglas F Covey; James W Simpkins
Mechanism of okadaic acid-induced neuronal death and the effect of estrogens.
Journal of neurochemistry 2009;108(3):732-40.
2009: Bryson W Katona; Shrikant Anant; Douglas F Covey; William F Stenson
Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines.
The Journal of biological chemistry 2009;284(5):3354-64.
2008: Gustav Akk; Ping Li; John R Bracamontes; David E Reichert; Douglas F Covey; Joe Henry Steinbach
Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids.
Molecular pharmacology 2008;74(3):614-27.
2008: Steven Mennerick; Michael Lamberta; Hong-Jin Shu; Joshua Hogins; Cunde Wang; Douglas F Covey; Lawrence N Eisenman; Charles F Zorumski
Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors.
Biophysical journal 2008;95(1):176-85.
2008: Jamie B Scaglione; Izabella Jastrzebska; Kathiresan Krishnan; Ping Li; Gustav Akk; Brad D Manion; Ann Benz; Amanda Taylor; Nigam P Rath; Alex S Evers; Charles F Zorumski; Steven Mennerick; Douglas F Covey
Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes.
Journal of medicinal chemistry 2008;51(5):1309-18.
2008: Kun Don YI; Zu Yun Cai; Douglas F Covey; James W Simpkins
Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation.
The Journal of pharmacology and experimental therapeutics 2008;324(3):1188-95.
2008: Juha-Matti Alakoskela; Karen Sabatini; Xin Jiang; Venla Laitala; Douglas F Covey; Paavo K J Kinnunen
Enantiospecific interactions between cholesterol and phospholipids.
Langmuir : the ACS journal of surfaces and colloids 2008;24(3):830-6.
2008: Bryson W Katona; Kathiresan Krishnan; Zu Yun Cai; Brad D Manion; Ann Benz; Amanda Taylor; Alex S Evers; Charles F Zorumski; Steven Mennerick; Douglas F Covey
Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens.
European journal of medicinal chemistry 2008;43(1):107-13.
2007: Pavle M Joksovic; Douglas F Covey; Slobodan M Todorovic
Inhibition of T-type calcium current in the reticular thalamic nucleus by a novel neuroactive steroid.
Annals of the New York Academy of Sciences 2007;1122():83-94.
2007: Bryson W Katona; Carolyn L Cummins; Andrew D Ferguson; Tingting Li; Daniel R Schmidt; David J Mangelsdorf; Douglas F Covey
Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids.
Journal of medicinal chemistry 2007;50(24):6048-58.
2007: Bryson W Katona; Nigam P Rath; Shrikant Anant; William F Stenson; Douglas F Covey
Enantiomeric deoxycholic acid: total synthesis, characterization, and preliminary toxicity toward colon cancer cell lines.
The Journal of organic chemistry 2007;72(24):9298-307.
2007: Ping Li; Hong-Jin Shu; Cunde Wang; Steven Mennerick; Charles F Zorumski; Douglas F Covey; Joe Henry Steinbach; Gustav Akk
Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation.
The Journal of physiology 2007;584(Pt 3):789-800.
2007: Yukitoshi Izumi; Kenki Murayama; Kazuhiro Tokuda; Kathiresan Krishnan; Douglas F Covey; Charles F Zorumski
GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices.
The European journal of neuroscience 2007;26(7):1881-8.
2007: Wenjun Li; Xiaochun Jin; Douglas F Covey; Joe Henry Steinbach
Neuroactive steroids and human recombinant rho1 GABAC receptors.
The Journal of pharmacology and experimental therapeutics 2007;323(1):236-47.
2007: Gustav Akk; Douglas F Covey; Alex S Evers; Joe Henry Steinbach; Charles F Zorumski; Steven Mennerick
Mechanisms of neurosteroid interactions with GABA(A) receptors.
Pharmacology & therapeutics 2007;116(1):35-57.
2007: Izabella Jastrzebska; Jamie B Scaglione; Gregory T DeKoster; Nigam P Rath; Douglas F Covey
Palladium-catalyzed potassium enoxyborate alkylation of enantiopure Hajos-Parrish indenone to construct rearranged steroid ring systems.
The Journal of organic chemistry 2007;72(13):4837-43.
2007: Ping Li; John R Bracamontes; Bryson W Katona; Douglas F Covey; Joe Henry Steinbach; Gustav Akk
Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor.
Molecular pharmacology 2007;71(6):1582-90.
2007: Lawrence N Eisenman; Hong-Jin Shu; Gustav Akk; Cunde Wang; Brad D Manion; Geraldine J Kress; Alex S Evers; Joe Henry Steinbach; Douglas F Covey; Charles F Zorumski; Steven Mennerick
Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light.
Nature neuroscience 2007;10(4):523-30.
2007: Zu Yun Cai; Douglas F Covey
A facile total synthesis of ent-17beta-estradiol and structurally related analogues.
Steroids 2007;72(4):351-9.
2007: Hong-Jin Shu; Chun-Min Zeng; Cunde Wang; Douglas F Covey; Charles F Zorumski; Steven Mennerick
Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions.
British journal of pharmacology 2007;150(2):164-75.
2007: Juha-Matti Alakoskela; Douglas F Covey; Paavo K J Kinnunen
Lack of enantiomeric specificity in the effects of anesthetic steroids on lipid bilayers.
Biochimica et biophysica acta 2007;1768(1):131-45.
2006: Emily J Westover; Xiaobo Lin; Terrence E Riehl; Lina Ma; William F Stenson; Douglas F Covey; Richard E Ostlund
Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters.
Journal of lipid research 2006;47(11):2374-81.
2006: Sriyani Pathirathna; Douglas F Covey; Slobodan M Todorovic; Vesna Jevtovic-Todorovic
Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats.
Pain 2006;125(1-2):53-64.
2006: Chendong Yang; Jeffrey G McDonald; Amit Patel; Yuan Zhang; Michihisa Umetani; Fang Xu; Emily J Westover; Douglas F Covey; David J Mangelsdorf; Jonathan C Cohen; Helen H Hobbs
Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.
The Journal of biological chemistry 2006;281(38):27816-26.
2006: Jamie B Scaglione; Brad D Manion; Ann Benz; Amanda Taylor; Gregory T DeKoster; Nigam P Rath; Alex S Evers; Charles F Zorumski; Steven Mennerick; Douglas F Covey
Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes.
Journal of medicinal chemistry 2006;49(15):4595-605.
2006: Xiaofei Wang; James A Dykens; Evelyn Perez; Ran Liu; Shaohua Yang; Douglas F Covey; James W Simpkins
Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells.
Molecular pharmacology 2006;70(1):395-404.
2006: Ping Li; Douglas F Covey; Joe Henry Steinbach; Gustav Akk
Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors.
Molecular pharmacology 2006;69(6):2015-26.
2006: Wenjun Li; Douglas F Covey; Juha-Matti Alakoskela; Paavo K J Kinnunen; Joe Henry Steinbach
Enantiomers of neuroactive steroids support a specific interaction with the GABA-C receptor as the mechanism of steroid action.
Molecular pharmacology 2006;69(6):1779-82.
2006: Emily J Westover; Douglas F Covey
Synthesis of ent-25-hydroxycholesterol.
Steroids 2006;71(6):484-8.
2005: Gustav Akk; Hong-Jin Shu; Cunde Wang; Joe Henry Steinbach; Charles F Zorumski; Douglas F Covey; Steven Mennerick
Neurosteroid access to the GABAA receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(50):11605-13.
2005: Jay Liu; Catherine C Y Chang; Emily J Westover; Douglas F Covey; Ta-Yuan Chang
Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies.
The Biochemical journal 2005;391(Pt 2):389-97.
2005: Sriyani Pathirathna; Slobodan M Todorovic; Douglas F Covey; Vesna Jevtovic-Todorovic
5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain.
Pain 2005;117(3):326-39.
2005: D Maneesh Kumar; Evelyn Perez; Zu Yun Cai; Paul Aoun; Anne-Marie Brun-Zinkernagel; Douglas F Covey; James W Simpkins; Neeraj Agarwal
Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity.
Free radical biology & medicine 2005;38(9):1152-63.
2005: Chun-Min Zeng; Brad D Manion; Ann Benz; Alex S Evers; Charles F Zorumski; Steven Mennerick; Douglas F Covey
Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.
Journal of medicinal chemistry 2005;48(8):3051-9.
2005: Sriyani Pathirathna; Barbara C Brimelow; Miljen M Jagodic; Kathiresan Krishnan; Xin Jiang; Charles F Zorumski; Steven Mennerick; Douglas F Covey; Slobodan M Todorovic; Vesna Jevtovic-Todorovic
New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids.
Pain 2005;114(3):429-43.
2005: Evelyn Perez; Ran Liu; Shao-Hua Yang; Zu Yun Cai; Douglas F Covey; James W Simpkins
Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo.
Brain research 2005;1038(2):216-22.
2005: Jamie B Scaglione; Nigam P Rath; Douglas F Covey
First synthesis of enantiopure 1,6-difunctionalized dodecahydrobenz[f]indenes.
The Journal of organic chemistry 2005;70(3):1089-92.
2005: Kimberley Evason; Cheng Huang; Idella Yamben; Douglas F Covey; Kerry Kornfeld
Anticonvulsant medications extend worm life-span.
Science (New York, N.Y.) 2005;307(5707):258-62.
2004: James A Dykens; Amy K Carroll; Sandra Wiley; Douglas F Covey; Zu Yun Cai; Lian Zhao; Rong Wen
Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog.
Biochemical pharmacology 2004;68(10):1971-84.
2004: Emily J Westover; Douglas F Covey
The enantiomer of cholesterol.
The Journal of membrane biology 2004;202(2):61-72.
2004: James W Simpkins; Shao-Hua Yang; Ran Liu; Evelyn Perez; Zu Yun Cai; Douglas F Covey; Pattie Green
Estrogen-like compounds for ischemic neuroprotection.
Stroke; a journal of cerebral circulation 2004;35(11 Suppl 1):2648-51.
2004: Slobodan M Todorovic; Sriyani Pathirathna; Barbara C Brimelow; Miljen M Jagodic; Seong-Hoon Ko; Xin Jiang; Kent R Nilsson; Charles F Zorumski; Douglas F Covey; Vesna Jevtovic-Todorovic
5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo.
Molecular pharmacology 2004;66(5):1223-35.
2004: Gregory Tochtrop; Gregory T DeKoster; Douglas F Covey; David Cistola
A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein.
Journal of the American Chemical Society 2004;126(35):11024-9.
2004: Yankun Li; Mingtao Ge; Laura Ciani; George Kuriakose; Emily J Westover; Miroslav Dura; Douglas F Covey; Jack H Freed; Frederick R Maxfield; Jonathan Lytton; Ira Tabas
Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages.
The Journal of biological chemistry 2004;279(35):37030-9.
2004: Hong-Jin Shu; Lawrence N Eisenman; Deepani Jinadasa; Douglas F Covey; Charles F Zorumski; Steven Mennerick
Slow actions of neuroactive steroids at GABAA receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(30):6667-75.
2004: Gustav Akk; John R Bracamontes; Douglas F Covey; Alex S Evers; Tim Dao; Joe Henry Steinbach
Neuroactive steroids have multiple actions to potentiate GABAA receptors.
The Journal of physiology 2004;558(Pt 1):59-74.
2004: Steven Mennerick; Yejun He; Xin Jiang; Brad D Manion; Mingde Wang; Amanda A Shute; Ann Benz; Alex S Evers; Douglas F Covey; Charles F Zorumski
Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors.
Molecular pharmacology 2004;65(5):1191-7.
2004: Eric B Gonzales; Cathy Lynne Bell-Horner; Maria Antonette M de la Cruz; James A Ferrendelli; Douglas F Covey; Glenn H Dillon
Enantioselectivity of alpha-benzyl-alpha-methyl-gamma-butyrolactone-mediated modulation of anticonvulsant activity and GABA(A) receptor function.
The Journal of pharmacology and experimental therapeutics 2004;309(2):677-83.
2004: Ramin Darbandi-Tonkabon; Brad D Manion; William R Hastings; William J Craigen; Gustav Akk; John R Bracamontes; Yejun He; Tatiana V Sheiko; Joe Henry Steinbach; Steven Mennerick; Douglas F Covey; Alex S Evers
Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia.
The Journal of pharmacology and experimental therapeutics 2004;308(2):502-11.
2004: Paromita Das; Cathy Lynne Bell-Horner; Ren-Qi Huang; Atul Raut; Eric B Gonzales; Z L Chen; Douglas F Covey; Glenn H Dillon
Inhibition of type A GABA receptors by L-type calcium channel blockers.
Neuroscience 2004;124(1):195-206.
2003: Emily J Westover; Douglas F Covey; Howard L Brockman; Rhoderick Brown; Linda J Pike
Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers.
The Journal of biological chemistry 2003;278(51):51125-33.
2003: Xin Jiang; Brad D Manion; Ann Benz; Nigam P Rath; Alex S Evers; Charles F Zorumski; Steven Mennerick; Douglas F Covey
Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.
Journal of medicinal chemistry 2003;46(25):5334-48.
2003: Alexander Zitzer; Emily J Westover; Douglas F Covey; Michael Palmer
Differential interaction of the two cholesterol-dependent, membrane-damaging toxins, streptolysin O and Vibrio cholerae cytolysin, with enantiomeric cholesterol.
FEBS letters 2003;553(3):229-31.
2003: Gregory Tochtrop; Jamie L Bruns; Changguo Tang; Douglas F Covey; David Cistola
Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein.
Biochemistry 2003;42(40):11561-7.
2003: Ramin Darbandi-Tonkabon; William R Hastings; Chun-Min Zeng; Gustav Akk; Brad D Manion; John R Bracamontes; Joe Henry Steinbach; Steven Mennerick; Douglas F Covey; Alex S Evers
Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain.
The Journal of biological chemistry 2003;278(15):13196-206.
2003: Emily J Westover; Douglas F Covey
First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol.
Steroids 2003;68(2):159-66.
2003: Richard J Auchus; A Sampath Kumar; C Andrew Boswell; Manisha K Gupta; Kristen Bruce; Nigam P Rath; Douglas F Covey
The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21.
Archives of biochemistry and biophysics 2003;409(1):134-44.
2002: Ran Liu; Shao-Hua Yang; Evelyn Perez; Kun Don YI; Samuel S Wu; Kathleen Eberst; Laszlo Prokai; Katalin Prokai-Tatrai; Zu Yun Cai; Douglas F Covey; Arthur L Day; James W Simpkins
Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysis.
Stroke; a journal of cerebral circulation 2002;33(10):2485-91.
2002: Gregory Tochtrop; Gregory T DeKoster; David Cistola; Douglas F Covey
Synthesis of [3,4-(13)c(2)]-enriched bile salts as NMR probes of protein-ligand interactions.
The Journal of organic chemistry 2002;67(19):6764-71.
2002: Xin Jiang; Douglas F Covey
Total synthesis of ent-cholesterol via a steroid C,D-ring side-chain synthon.
The Journal of organic chemistry 2002;67(14):4893-900.
2002: Mingde Wang; Yejun He; Lawrence N Eisenman; Christopher Fields; Chun-Min Zeng; Jose Mathews; Ann Benz; Tao Fu; Erik Zorumski; Joe Henry Steinbach; Douglas F Covey; Charles F Zorumski; Steven Mennerick
3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(9):3366-75.
2002: SHULI XIA; Zu Yun Cai; Liu Lin Thio; Jeong Sook Kim-Han; Laura L Dugan; Douglas F Covey; Steven M Rothman
The estrogen receptor is not essential for all estrogen neuroprotection: new evidence from a new analog.
Neurobiology of disease 2002;9(3):282-93.
2002: Richard E Ostlund; Janet B McGill; Chun-Min Zeng; Douglas F Covey; Jay Stearns; William F Stenson; Curtis A Spilburg
Gastrointestinal absorption and plasma kinetics of soy Delta(5)-phytosterols and phytostanols in humans.
American journal of physiology. Endocrinology and metabolism 2002;282(4):E911-6.
2002: Gregory Tochtrop; Klaus Richter; Changguo Tang; James J Toner; Douglas F Covey; David Cistola
Energetics by NMR: site-specific binding in a positively cooperative system.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):1847-52.
2002: Gregory Tochtrop; Gregory T DeKoster; David Cistola; Douglas F Covey
A simple efficient synthesis of [23,24]-(13)C(2)-labeled bile salts as NMR probes of protein-ligand interactions.
Bioorganic & medicinal chemistry letters 2002;12(3):433-5.
2002: Yejun He; Ann Benz; Tao Fu; Mingde Wang; Douglas F Covey; Charles F Zorumski; Steven Mennerick
Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function.
Neuropharmacology 2002;42(2):199-209.
2001: C Michael Crowder; Emily J Westover; A S Kumar; Richard E Ostlund; Douglas F Covey
Enantiospecificity of cholesterol function in vivo.
The Journal of biological chemistry 2001;276(48):44369-72.
2001: Steven Mennerick; Chun-Min Zeng; Ann Benz; W Shen; Y Izumi; Alex S Evers; Douglas F Covey; Charles F Zorumski
Effects on gamma-aminobutyric acid (GABA)(A) receptors of a neuroactive steroid that negatively modulates glutamate neurotransmission and augments GABA neurotransmission.
Molecular pharmacology 2001;60(4):732-41.
2001: Ren-Qi Huang; Cathy Lynne Bell-Horner; Mohammed I Dibas; Douglas F Covey; John Drewe; Glenn H Dillon
Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action.
The Journal of pharmacology and experimental therapeutics 2001;298(3):986-95.
2000: Charles F Zorumski; Steven Mennerick; Keith E Isenberg; Douglas F Covey
Potential clinical uses of neuroactive steroids.
Current opinion in investigational drugs (London, England : 2000) 2000;1(3):360-9.
2000: Charles F Zorumski; Steven Mennerick; Keith E Isenberg; Douglas F Covey
Potential clinical uses of neuroactive steroids.
IDrugs : the investigational drugs journal 2000;3(9):1053-63.
2000: Douglas F Covey; M Han; A S Kumar; M A de La Cruz; E S Meadows; Y Hu; A Tonnies; D Nathan; M Coleman; Ann Benz; Alex S Evers; Charles F Zorumski; Steven Mennerick
Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one.
Journal of medicinal chemistry 2000;43(17):3201-4.
2000: KG Paradiso; K Sabey; Alex S Evers; Charles F Zorumski; Douglas F Covey; Joe Henry Steinbach
Steroid inhibition of rat neuronal nicotinic alpha4beta2 receptors expressed in HEK 293 cells.
Molecular pharmacology 2000;58(2):341-51.
2000: Gary D Luker; Christina M Pica; A S Kumar; Douglas F Covey; David Piwnica-Worms
Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains.
Biochemistry 2000;39(26):7651-61.
2000: Joe Henry Steinbach; John R Bracamontes; L Yu; P Zhang; Douglas F Covey
Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane-spanning region.
Molecular pharmacology 2000;58(1):11-7.
2000: X Jiang; C Wang; Y Hu; H Hu; Douglas F Covey
A practical and facile route for the preparation of 18-norandrostan-17-ones from androstan-17-ones using SmI(2)-promoted cyclization and dehydroxylation.
The Journal of organic chemistry 2000;65(11):3555-7.
2000: Douglas F Covey; D Nathan; M Kalkbrenner; Kent R Nilsson; Y Hu; Charles F Zorumski; Alex S Evers
Enantioselectivity of pregnanolone-induced gamma-aminobutyric acid(A) receptor modulation and anesthesia.
The Journal of pharmacology and experimental therapeutics 2000;293(3):1009-16.
2000: W Xu; Robert J Cormier; Tao Fu; Douglas F Covey; Keith E Isenberg; Charles F Zorumski; Steven Mennerick
Slow death of postnatal hippocampal neurons by GABA(A) receptor overactivation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(9):3147-56.
2000: C Zeng; M Han; Douglas F Covey
Neurosteroid analogues. 7. A synthetic route for the conversion of 5 beta-methyl-3-ketosteroids into 7(S)-methyl-substituted analogues of neuroactive benz[e]indenes.
The Journal of organic chemistry 2000;65(7):2264-6.
1999: MW Hill; M A de la Cruz; Douglas F Covey; Steven M Rothman
Effects of anticonvulsant lactams on in vitro seizures in the hippocampal slice preparation.
Epilepsy research 1999;37(2):121-31.
1999: YM Nakashima; A Pereverzev; Toni Schneider; Douglas F Covey; Christopher J Lingle
Blockade of Ba2+ current through human alpha1E channels by two steroid analogs, (+)-ACN and (+)-ECN.
Neuropharmacology 1999;38(6):843-55.
1999: Gary D Luker; Kent R Nilsson; Douglas F Covey; David Piwnica-Worms
Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol.
The Journal of biological chemistry 1999;274(11):6979-91.
1999: W Shen; Steven Mennerick; E C Zorumski; Douglas F Covey; Charles F Zorumski
Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors.
Neuropharmacology 1999;38(2):267-71.
1998: Slobodan M Todorovic; Murali Prakriya; YM Nakashima; Kent R Nilsson; M Han; Charles F Zorumski; Douglas F Covey; Christopher J Lingle
Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity.
Molecular pharmacology 1998;54(5):918-27.
1998: K A Yamada; MW Hill; Y Hu; Douglas F Covey
The diazoxide derivative 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide augments AMPA- and GABA-mediated synaptic responses in cultured hippocampal neurons.
Neurobiology of disease 1998;5(3):196-205.
1998: YM Nakashima; Slobodan M Todorovic; Douglas F Covey; Christopher J Lingle
The anesthetic steroid (+)-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile blocks N-, Q-, and R-type, but not L- and P-type, high voltage-activated Ca2+ current in hippocampal and dorsal root ganglion neurons of the rat.
Molecular pharmacology 1998;54(3):559-68.
1998: MW Hill; PA Reddy; Douglas F Covey; Steven M Rothman
Contribution of subsaturating GABA concentrations to IPSCs in cultured hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(14):5103-11.
1998: Kent R Nilsson; Charles F Zorumski; Douglas F Covey
Neurosteroid analogues. 6. The synthesis and GABAA receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3alpha,5beta)-3-hydroxypregnan-20-one sulfate.
Journal of medicinal chemistry 1998;41(14):2604-13.
1998: MW Hill; PA Reddy; Douglas F Covey; Steven M Rothman
Inhibition of voltage-dependent sodium channels by the anticonvulsant gamma-aminobutyric acid type A receptor modulator, 3-benzyl-3-ethyl-2-piperidinone.
The Journal of pharmacology and experimental therapeutics 1998;285(3):1303-9.
1998: Charles F Zorumski; Steven Mennerick; Douglas F Covey
Enantioselective modulation of GABAergic synaptic transmission by steroids and benz[e]indenes in hippocampal microcultures.
Synapse (New York, N.Y.) 1998;29(2):162-71.
1998: DJ Canney; H F Lu; A C McKeon; K W Yoon; K Xu; K D Holland; Steven M Rothman; James A Ferrendelli; Douglas F Covey
Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function.
Bioorganic & medicinal chemistry 1998;6(1):43-55.
1997: K L Williams; JB Tucker; G White; D S Weiss; James A Ferrendelli; Douglas F Covey; James E Krause; Steven M Rothman
Lactone modulation of the gamma-aminobutyric acid A receptor: evidence for a positive modulatory site.
Molecular pharmacology 1997;52(1):114-9.
1997: Robert A Gross; Douglas F Covey; James A Ferrendelli
Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones.
The Journal of pharmacology and experimental therapeutics 1997;280(2):686-94.
1997: PA Reddy; K E Woodward; S M McIlheran; B C Hsiang; TN Latifi; MW Hill; Steven M Rothman; James A Ferrendelli; Douglas F Covey
Synthesis and anticonvulsant activities of 3,3-dialkyl- and 3-alkyl-3-benzyl-2-piperidinones (delta-valerolactams) and hexahydro-2H-azepin-2-ones (epsilon-caprolactams).
Journal of medicinal chemistry 1997;40(1):44-9.
1996: L L Wittmer; Y Hu; M Kalkbrenner; A S Evers; Charles F Zorumski; Douglas F Covey
Enantioselectivity of steroid-induced gamma-aminobutyric acidA receptor modulation and anesthesia.
Molecular pharmacology 1996;50(6):1581-6.
1996: M Han; Charles F Zorumski; Douglas F Covey
Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABAA receptors.
Journal of medicinal chemistry 1996;39(21):4218-32.
1996: P A Reddy; B C Hsiang; T N Latifi; MW Hill; K E Woodward; Steven M Rothman; James A Ferrendelli; Douglas F Covey
3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: a new class of anticonvulsant agents.
Journal of medicinal chemistry 1996;39(9):1898-906.
1996: Gregory Mathews; A M Bolos-Sy; Douglas F Covey; Steven M Rothman; James A Ferrendelli
Physiological comparison of alpha-ethyl-alpha-methyl-gamma-thiobutyrolactone with benzodiazepine and barbiturate modulators of GABAA receptors.
Neuropharmacology 1996;35(2):123-36.
1996: Charles F Zorumski; L L Wittmer; Keith E Isenberg; Y Hu; Douglas F Covey
Effects of neurosteroid and benz[e]indene enantiomers on GABAA receptors in cultured hippocampal neurons and transfected HEK-293 cells.
Neuropharmacology 1996;35(9-10):1161-8.
1995: M Han; Y Hu; Charles F Zorumski; Douglas F Covey
Neurosteroid analogues. 3. The synthesis and electrophysiological evaluation of benz[e]indene congeners of neuroactive steroids having the 5 beta-configuration.
Journal of medicinal chemistry 1995;38(22):4548-56.
1995: Y Hu; P F Sherwin; Douglas F Covey
Synthesis of (17R)- and (17S)-17-hydroxy-14, 15-secoandrost-4-en-15-yn-3-one and the X-ray crystal structure of the (17S)-diastereomer.
Steroids 1995;60(6):491-6.
1995: K D Holland; Gregory Mathews; A M Bolos-Sy; J B Tucker; P A Reddy; Douglas F Covey; James A Ferrendelli; Steven M Rothman
Dual modulation of the gamma-aminobutyric acid type A receptor/ionophore by alkyl-substituted gamma-butyrolactones.
Molecular pharmacology 1995;47(6):1217-23.
1995: Y Hu; P F Sherwin; Douglas F Covey
Synthesis of (17R)- and (17S)-17-hydroxy-14, 15-secoandrost-4-en-15-yn-3-one and the X-ray crystal structure of the (17S)-diastereomer.
Steroids 1995;60(3):250-5.
1994: Gregory Mathews; A M Bolos-Sy; K D Holland; Keith E Isenberg; Douglas F Covey; James A Ferrendelli; Steven M Rothman
Developmental alteration in GABAA receptor structure and physiological properties in cultured cerebellar granule neurons.
Neuron 1994;13(1):149-58.
1994: E M Peterson; K Xu; K D Holland; A C McKeon; Steven M Rothman; James A Ferrendelli; Douglas F Covey
Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones.
Journal of medicinal chemistry 1994;37(2):275-86.
1993: Y Hu; C F Zorumski; Douglas F Covey
Neurosteroid analogues: structure-activity studies of benz[e]indene modulators of GABAA receptor function. 1. The effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles.
Journal of medicinal chemistry 1993;36(24):3956-67.
1993: K D Holland; M G Bouley; Douglas F Covey; James A Ferrendelli
Alkyl-substituted gamma-butyrolactones act at a distinct site allosterically linked to the TBPS/picrotoxinin site on the GABAA receptor complex.
Brain research 1993;615(1):170-4.
1993: K W Yoon; Douglas F Covey; Steven M Rothman
Multiple mechanisms of picrotoxin block of GABA-induced currents in rat hippocampal neurons.
The Journal of physiology 1993;464():423-39.
1993: Douglas F Covey; Y Hu; M G Bouley; K D Holland; N T Rodgers-Neame; Keith E Isenberg; Charles F Zorumski
Modulation of GABAA receptor function by benz[e]indenes and phenanthrenes.
Journal of medicinal chemistry 1993;36(5):627-30.
1993: D J Canney; Douglas F Covey; A S Evers
Direct observation of a fluorinated anticonvulsant in brain tissue using 19F-NMR techniques.
Biochemical pharmacology 1993;45(4):949-59.
1992: N T Rodgers-Neame; Douglas F Covey; Y Hu; Keith E Isenberg; Charles F Zorumski
Effects of a benz[e]indene on gamma-aminobutyric acid-gated chloride currents in cultured postnatal rat hippocampal neurons.
Molecular pharmacology 1992;42(6):952-7.
1992: K D Holland; A C McKeon; D J Canney; Douglas F Covey; James A Ferrendelli
Relative anticonvulsant effects of GABAmimetic and GABA modulatory agents.
Epilepsia 1992;33(6):981-6.
1991: D J Canney; K D Holland; J A Levine; A C McKeon; James A Ferrendelli; Douglas F Covey
Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor.
Journal of medicinal chemistry 1991;34(4):1460-7.
1991: K D Holland; K W Yoon; James A Ferrendelli; Douglas F Covey; Steven M Rothman
Gamma-butyrolactone antagonism of the picrotoxin receptor: comparison of a pure antagonist and a mixed antagonist/inverse agonist.
Molecular pharmacology 1991;39(1):79-84.
1990: K W Yoon; D J Canney; Douglas F Covey; Steven M Rothman
Modulation of the picrotoxin receptor by fluorinated ethyl, methyl-butyrolactones.
The Journal of pharmacology and experimental therapeutics 1990;255(1):248-55.
1990: S S Lawate; Douglas F Covey
Trifluoromethylacetylenic alcohols as affinity labels: inactivation of estradiol dehydrogenase by a trifluoromethylacetylenic secostradiol.
Journal of medicinal chemistry 1990;33(9):2319-21.
1990: K D Holland; A C McKeon; Douglas F Covey; James A Ferrendelli
Binding interactions of convulsant and anticonvulsant gamma-butyrolactones and gamma-thiobutyrolactones with the picrotoxin receptor.
The Journal of pharmacology and experimental therapeutics 1990;254(2):578-83.
1990: K D Holland; James A Ferrendelli; Douglas F Covey; Steven M Rothman
Physiological regulation of the picrotoxin receptor by gamma-butyrolactones and gamma-thiobutyrolactones in cultured hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(6):1719-27.
1990: K D Holland; D J Canney; Steven M Rothman; James A Ferrendelli; Douglas F Covey
Physiological modulation of the GABA receptor by convulsant and anticonvulsant barbiturates in cultured rat hippocampal neurons.
Brain research 1990;516(1):147-50.
1990: K D Holland; D K Naritoku; A C McKeon; James A Ferrendelli; Douglas F Covey
Convulsant and anticonvulsant cyclopentanones and cyclohexanones.
Molecular pharmacology 1990;37(1):98-103.
1989: James A Ferrendelli; K D Holland; A C McKeon; Douglas F Covey
Comparison of the anticonvulsant activities of ethosuximide, valproate, and a new anticonvulsant, thiobutyrolactone.
Epilepsia 1989;30(5):617-22.
1989: Charles F Zorumski; J Yang; K Baker; Douglas F Covey; D B Clifford
Convulsant gamma-butyrolactones block GABA currents in cultured chick spinal cord neurons.
Brain research 1989;484(1-2):102-10.
1989: P F Sherwin; P C McMullan; Douglas F Covey
Effects of steroid D-ring modification on suicide inactivation and competitive inhibition of aromatase by analogues of androsta-1,4-diene-3,17-dione.
Journal of medicinal chemistry 1989;32(3):651-8.
1989: R J Auchus; J O Palmer; H L Carrell; Douglas F Covey
Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase.
Steroids 1989;53(1-2):77-96.
1988: Douglas F Covey; P C McMullan; L L Wixler; M Cabell
[19-14C]androstenedione: a new substrate for assaying aromatase and studying its reaction mechanism.
Biochemical and biophysical research communications 1988;157(1):81-6.
1988: R J Auchus; Douglas F Covey; V Bork; J Schaefer
Solid-state NMR observation of cysteine and lysine Michael adducts of inactivated estradiol dehydrogenase.
The Journal of biological chemistry 1988;263(24):11640-5.
1987: Denise Beusen; H L Carrell; Douglas F Covey
Metabolism of 19-methyl-substituted steroids by human placental aromatase.
Biochemistry 1987;26(24):7833-41.
1987: Douglas F Covey; H L Carrell; Denise Beusen
Metabolism of 19-methyl substituted steroids and a proposal for the third aromatase monooxygenation.
Steroids 1987;50(4-6):363-74.
1987: D K Naritoku; J A Levine; Douglas F Covey; James A Ferrendelli
Effects of anticonvulsant and convulsant gamma-butyrolactones and thiobutyrolactones on GABA-mediated chloride uptake.
Biochemical pharmacology 1987;36(6):797-800.
1986: R J Auchus; Douglas F Covey
Mechanism-based inactivation of 17 beta,20 alpha-hydroxysteroid dehydrogenase by an acetylenic secoestradiol.
Biochemistry 1986;25(23):7295-300.
1986: Douglas F Covey; P C McMullan; A J Weaver; W W Chien
Inactivation of Streptomyces hydrogenans 20 beta-hydroxysteroid dehydrogenase by an enzyme-generated ethoxyacetylenic ketone in the presence of a thiol.
Biochemistry 1986;25(23):7288-94.
1986: J A Levine; James A Ferrendelli; Douglas F Covey
Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
Journal of medicinal chemistry 1986;29(10):1996-9.
1986: Douglas F Covey; W F Hood; P C McMullan
Studies of the inactivation of human placental aromatase by 17 alpha-ethynyl-substituted 10 beta-hydroperoxy and related 19-nor steroids.
Biochemical pharmacology 1986;35(10):1671-4.
1985: J A Levine; James A Ferrendelli; Douglas F Covey
Convulsant and anti-convulsant gammabutyrolactones bind at the picrotoxinin/T-butylbicyclophosphorothionate (TBPS) receptor.
Biochemical pharmacology 1985;34(23):4187-90.
1985: R J Auchus; D B Wilson; Douglas F Covey; P W Majerus
The 5-hydroxyl of myo-inositol is essential for uptake into HSDM1C1 mouse fibrosarcoma cells.
Biochemical and biophysical research communications 1985;130(3):1139-46.
1984: Douglas F Covey; W F Hood; Denise Beusen; H L Carrell
Hydroperoxides as inactivators of aromatase: 10 beta-hydroperoxy-4-estrene-3,17-dione, crystal structure and inactivation characteristics.
Biochemistry 1984;23(23):5398-406.
1984: Denise Beusen; Douglas F Covey
Study of the role of Schiff base formation in the aromatization of 3-[18O]testosterone and 3,17-di-[18O]androstenedione by human placental aromatase.
Journal of steroid biochemistry 1984;20(4A):931-4.
1983: William E Klunk; Douglas F Covey; James A Ferrendelli
Alkyl-substituted gamma-butyrolactones as potential tools in the study and treatment of epilepsy.
Biochemical pharmacology 1983;32(20):2999-3004.
1983: William E Klunk; B L Kalman; James A Ferrendelli; Douglas F Covey
Computer-assisted modeling of the picrotoxinin and gamma-butyrolactone receptor site.
Molecular pharmacology 1983;23(2):511-8.
1982: William E Klunk; A McKeon; Douglas F Covey; James A Ferrendelli
Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs.
Science (New York, N.Y.) 1982;217(4564):1040-2.
1982: William E Klunk; Douglas F Covey; James A Ferrendelli
Structure-activity relationships of alkyl-substituted gamma-butyrolactones and succinimides.
Molecular pharmacology 1982;22(2):444-50.
1982: William E Klunk; Douglas F Covey; James A Ferrendelli
Anticonvulsant properties of alpha, gamma, and alpha, gamma-substituted gamma-butyrolactones.
Molecular pharmacology 1982;22(2):438-43.
1982: William E Klunk; Douglas F Covey; James A Ferrendelli
Comparison of epileptogenic properties of unsubstituted and beta-alkyl-substituted gamma-butyrolactones.
Molecular pharmacology 1982;22(2):431-7.