Maryanne Covington

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Sign-in to see full Profile

Sign-in to see all Coauthors

Publications

TOP 3
Li Yun-Long; Shi Eric; Burns David; Li Yanlong; Covington Maryanne B; Pan Maxwell; Scherle Peggy; Friedman Steve; Metcalf Brian; Yao Wenqing
Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety.
Shin Niu; Baribaud Frédéric; Wang Kathy; Yang Genjie; Wynn Rich; Covington Maryanne B; Feldman Patricia; Gallagher Karen B; Leffet Lynn M; Lo Yvonne Y; Wang Anlai; Xue Chu-Biao; Newton Robert C; Scherle Peggy A
Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2.
Burns David M; Li Yun-Long; Shi Eric; He Chunhong; Xu Meizhong; Zhuo Jincong; Zhang Colin; Qian Ding-Quan; Li Yanlong; Wynn Richard; Covington Maryanne B; Katiyar Kamna; Marando Cindy A; Fridman Jordan S; Scherle Peggy; Friedman Steve; Metcalf Brian; Yao Wenqing
Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of Maryanne Covington (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Li Yun-Long; Shi Eric; Burns David; Li Yanlong; Covington Maryanne B; Pan Maxwell; Scherle Peggy; Friedman Steve; Metcalf Brian; Yao Wenqing
Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety.
Bioorganic & medicinal chemistry letters 2009;19(17):5037-42.
2009: Shin Niu; Baribaud Frédéric; Wang Kathy; Yang Genjie; Wynn Rich; Covington Maryanne B; Feldman Patricia; Gallagher Karen B; Leffet Lynn M; Lo Yvonne Y; Wang Anlai; Xue Chu-Biao; Newton Robert C; Scherle Peggy A
Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2.
Biochemical and biophysical research communications 2009;387(2):251-5.
2009: Burns David M; Li Yun-Long; Shi Eric; He Chunhong; Xu Meizhong; Zhuo Jincong; Zhang Colin; Qian Ding-Quan; Li Yanlong; Wynn Richard; Covington Maryanne B; Katiyar Kamna; Marando Cindy A; Fridman Jordan S; Scherle Peggy; Friedman Steve; Metcalf Brian; Yao Wenqing
Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition.
Bioorganic & medicinal chemistry letters 2009;19(13):3525-30.
2008: Lu Zhonghui; Ott Gregory R; Anand Rajan; Liu Rui-Qin; Covington Maryanne B; Vaddi Krishna; Qian Mingxin; Newton Robert C; Christ David D; Trzaskos James; Duan James J-W
Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents.
Bioorganic & medicinal chemistry letters 2008;18(6):1958-62.
2008: Ott Gregory R; Asakawa Naoyuki; Lu Zhonghui; Anand Rajan; Liu Rui-Qin; Covington Maryanne B; Vaddi Krishna; Qian Mingxin; Newton Robert C; Christ David D; Trzaskos James M; Duan James J-W
Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.
Bioorganic & medicinal chemistry letters 2008;18(5):1577-82.
2008: Ott Gregory R; Asakawa Naoyuki; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Vaddi Krishna; Newton Robert C; Trzaskos James M; Christ David D; Galya Laurine; Scholz Thomas; Marshall Will; Duan James J-W
Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2008;18(4):1288-92.
2008: Burns David M; He Chunhong; Li Yanlong; Scherle Peggy; Liu Xiangdong; Marando Cindy A; Covington Mayanne B; Yang Gengjie; Pan Max; Turner Sharon; Fridman Jordan S; Hollis Gregory; Vaddi Kris; Yeleswaram Swamy; Newton Robert; Friedman Steve; Metcalf Brian; Yao Wenqing
Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations.
Bioorganic & medicinal chemistry letters 2008;18(2):560-4.
2008: Ott Gregory R; Asakawa Naoyuki; Lu Zhonghui; Liu Rui-Qin; Covington Maryanne B; Vaddi Krishna; Qian Mingxin; Newton Robert C; Christ David D; Traskos James M; Decicco Carl P; Duan James J-W
Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2008;18(2):694-9.
2008: Yao Wenqing; Zhuo Jincong; Burns David M; Li Yun-Long; Qian Ding-Quan; Zhang Colin; He Chunhong; Xu Meizhong; Shi Eric; Li Yanlong; Marando Cindy A; Covington Maryanne B; Yang Gengjie; Liu Xiangdong; Pan Max; Fridman Jordan S; Scherle Peggy; Wasserman Zelda R; Hollis Gregory; Vaddi Kris; Yeleswaram Swamy; Newton Robert; Friedman Steve; Metcalf Brian
Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis.
Bioorganic & medicinal chemistry letters 2008;18(1):159-63.
2008: Duan James J-W; Chen Lihua; Lu Zhonghui; Xue Chu-Biao; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Wasserman Zelda R; Vaddi Krishna; Christ David D; Trzaskos James M; Newton Robert C; Decicco Carl P
Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(1):241-6.
2007: Qian Mingxin; Bai Stephen A; Brogdon Bernice; Wu Jing-Tao; Liu Rui-Qin; Covington Maryanne B; Vaddi Kris; Newton Robert C; Fossler Michael J; Garner C Edwin; Deng Yuzhong; Maduskuie Thomas; Trzaskos James; Duan James J-W; Decicco Carl P; Christ David D
Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(10):1916-25.
2007: Gilmore John L; King Bryan W; Asakawa Naoyuki; Harrison Kimberly; Tebben Andrew; Sheppeck James E; Liu Rui-Qin; Covington Maryanne; Duan James J-W
Synthesis and structure-activity relationship of a novel, non-hydroxamate series of TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(16):4678-82.
2007: Pruitt James R; Batt Douglas G; Wacker Dean A; Bostrom Lori L; Booker Shon K; McLaughlin Erin; Houghton Gregory C; Varnes Jeffrey G; Christ David D; Covington Maryanne; Das Anuk M; Davies Paul; Graden Danielle; Kariv Ilona; Orlovsky Yevgeniya; Stowell Nicole C; Vaddi Krishna G; Wadman Eric A; Welch Patricia K; Yeleswaram Swamy; Solomon Kimberly A; Newton Robert C; Decicco Carl P; Carter Percy H; Ko Soo S
CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
Bioorganic & medicinal chemistry letters 2007;17(11):2992-7.
2007: Chen Xiao-Tao; Ghavimi Bahman; Corbett Ronald L; Xue Chu-Biao; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Vaddi Krishna G; Christ David D; Hartman Karl D; Ribadeneira Maria D; Trzaskos James M; Newton Robert C; Decicco Carl P; Duan James J-W
A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(7):1865-70.
2007: Sheppeck James E; Gilmore John L; Yang Anle; Chen Xiao-Tao; Xue Chu-Biao; Roderick John; Liu Rui-Qin; Covington Maryanne B; Decicco Carl P; Duan James J-W
Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2007;17(5):1413-7.
2007: Duan James J-W; Chen Lihua; Lu Zhonghui; Jiang Bin; Asakawa Naoyuki; Sheppeck James E; Liu Rui-Qin; Covington Maryanne B; Pitts William; Kim Soong-Hoon; Decicco Carl P
Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2007;17(1):266-71.
2006: Watson Paul S; Jiang Bin; Harrison Kim; Asakawa Nao; Welch Patricia K; Covington Maryanne; Stowell Nicole C; Wadman Eric A; Davies Paul; Solomon Kimberly A; Newton Robert C; Trainor George L; Friedman Steven M; Decicco Carl P; Ko Soo S
2,4-Disubstituted piperidines as selective CC chemokine receptor 3 (CCR3) antagonists: synthesis and selectivity.
Bioorganic & medicinal chemistry letters 2006;16(21):5695-9.
2006: Das Anuk M; Vaddi Krishna G; Solomon Kimberly A; Krauthauser Candice; Jiang Xiaosui; McIntyre Kim W; Yang Xiao Xia; Wadman Eric; Welch Patricia; Covington Maryanne; Graden Danielle; Yeleswaram Krishnaswamy; Trzaskos James M; Newton Robert C; Mandlekar Sandhya; Ko Soo S; Carter Percy H; Davies Paul
Selective inhibition of eosinophil influx into the lung by small molecule CC chemokine receptor 3 antagonists in mouse models of allergic inflammation.
The Journal of pharmacology and experimental therapeutics 2006;318(1):411-7.
2006: Liu Xiangdong; Fridman Jordan S; Wang Qian; Caulder Eian; Yang Gengjie; Covington Maryanne; Liu Changnian; Marando Cindy; Zhuo Jincong; Li Yanlong; Yao Wenqing; Vaddi Kris; Newton Robert C; Scherle Peggy A; Friedman Steven M
Selective inhibition of ADAM metalloproteases blocks HER-2 extracellular domain (ECD) cleavage and potentiates the anti-tumor effects of trastuzumab.
Cancer biology & therapy 2006;5(6):648-56.
2006: Gilmore John L; King Bryan W; Harris Cathy; Maduskuie Thomas; Mercer Stephen E; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Ribadeneria Maria D; Vaddi Krishna; Trzaskos James M; Newton Robert C; Decicco Carl P; Duan James J-W
Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(10):2699-704.
2006: Cherney Robert J; King Bryan W; Gilmore John L; Liu Rui-Qin; Covington Maryanne B; Duan James J-W; Decicco Carl P
Conversion of potent MMP inhibitors into selective TACE inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(4):1028-31.
2005: Brodmerkel Carrie M; Huber Reid; Covington Maryanne; Diamond Sharon; Hall Leslie; Collins Robert; Leffet Lynn; Gallagher Karen; Feldman Patricia; Collier Paul; Stow Mark; Gu Xiaomei; Baribaud Frederic; Shin Niu; Thomas Beth; Burn Tim; Hollis Greg; Yeleswaram Swamy; Solomon Kim; Friedman Steve; Wang Anlai; Xue Chu Biao; Newton Robert C; Scherle Peggy; Vaddi Kris
Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(8):5370-8.
2005: Duan James J-W; Lu Zhonghui; Wasserman Zelda R; Liu Rui-Qin; Covington Maryanne B; Decicco Carl P
Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-alpha converting enzyme.
Bioorganic & medicinal chemistry letters 2005;15(12):2970-3.
2005: De Lucca George V; Kim Ui Tae; Vargo Brian J; Duncia John V; Santella Joseph B; Gardner Daniel S; Zheng Changsheng; Liauw Ann; Wang Zhang; Emmett George; Wacker Dean A; Welch Patricia K; Covington Maryanne; Stowell Nicole C; Wadman Eric A; Das Anuk M; Davies Paul; Yeleswaram Swamy; Graden Danielle M; Solomon Kimberly A; Newton Robert C; Trainor George L; Decicco Carl P; Ko Soo S
Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.
Journal of medicinal chemistry 2005;48(6):2194-211.
2004: Xue Chu-Biao; Chen Xiao-Tao; He Xiaohua; Roderick John; Corbett Ronald L; Ghavimi Bahman; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Ribadeneira Maria D; Vaddi Krishna; Trzaskos James; Newton Robert C; Duan James J-W; Decicco Carl P
Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors.
Bioorganic & medicinal chemistry letters 2004;14(17):4453-9.
2004: Cherney Robert J; Mo Ruowei; Meyer Dayton T; Hardman Karl D; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Wasserman Zelda R; Christ David D; Trzaskos James M; Newton Robert C; Decicco Carl P
Sultam hydroxamates as novel matrix metalloproteinase inhibitors.
Journal of medicinal chemistry 2004;47(12):2981-3.
2004: Varnes Jeffrey G; Gardner Daniel S; Santella Joseph B; Duncia John V; Estrella Melissa; Watson Paul S; Clark Cheryl M; Ko Soo S; Welch Patricia; Covington Maryanne; Stowell Nicole; Wadman Eric; Davies Paul; Solomon Kimberley; Newton Robert C; Trainor George L; Decicco Carl P; Wacker Dean A
Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists.
Bioorganic & medicinal chemistry letters 2004;14(7):1645-9.
2003: Xue Chu-Biao; He Xiaohua; Roderick John; Corbett Ronald L; Duan James J-W; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Ribadeneira Maria D; Vaddi Krishna; Christ David D; Newton Robert C; Trzaskos James M; Magolda Ronald L; Wexler Ruth R; Decicco Carl P
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.
Bioorganic & medicinal chemistry letters 2003;13(24):4299-304.
2003: Xue Chu-Biao; He Xiaohua; Roderick John; Corbett Ronald L; Duan James J-W; Liu Rui-Qin; Covington Maryanne B; Newton Robert C; Trzaskos James M; Magolda Ronald L; Wexler Ruth R; Decicco Carl P
Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 1: lead identification.
Bioorganic & medicinal chemistry letters 2003;13(24):4293-7.
2003: Duan James J-W; Lu Zhonghui; Xue Chu-Biao; He Xiaohua; Seng Jennifer L; Roderick John J; Wasserman Zelda R; Liu Rui-Qin; Covington Maryanne B; Magolda Ronald L; Newton Robert C; Trzaskos James M; Decicco Carl P
Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).
Bioorganic & medicinal chemistry letters 2003;13(12):2035-40.
2003: Cherney Robert J; Duan James J-W; Voss Matthew E; Chen Lihua; Wang Li; Meyer Dayton T; Wasserman Zelda R; Hardman Karl D; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Mandlekar Sandhya; Christ David D; Trzaskos James M; Newton Robert C; Magolda Ronald L; Wexler Ruth R; Decicco Carl P
Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.
Journal of medicinal chemistry 2003;46(10):1811-23.
2003: Cherney Robert J; Mo Ruowei; Meyer Dayton T; Wang Li; Yao Wenqing; Wasserman Zelda R; Liu Rui-Qin; Covington Maryanne B; Tortorella Micky D; Arner Elizabeth C; Qian Mingxin; Christ David D; Trzaskos James M; Newton Robert C; Magolda Ron L; Decicco Carl P
Potent and selective aggrecanase inhibitors containing cyclic P1 substituents.
Bioorganic & medicinal chemistry letters 2003;13(7):1297-300.
2002: Duan James J-W; Chen Lihua; Wasserman Zelda R; Lu Zhonghui; Liu Rui-Qin; Covington Maryanne B; Qian Mingxin; Hardman Karl D; Magolda Ronald L; Newton Robert C; Christ David D; Wexler Ruth R; Decicco Carl P
Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.
Journal of medicinal chemistry 2002;45(23):4954-7.
2002: De Lucca George V; Kim Ui T; Johnson Curt; Vargo Brian J; Welch Patricia K; Covington Maryanne; Davies Paul; Solomon Kimberly A; Newton Robert C; Trainor George L; Decicco Carl P; Ko Soo S
Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists.
Journal of medicinal chemistry 2002;45(17):3794-804.
2002: Wacker Dean A; Santella Joseph B; Gardner Daniel S; Varnes Jeffrey G; Estrella Melissa; DeLucca George V; Ko Soo S; Tanabe Keiichi; Watson Paul S; Welch Patricia K; Covington Maryanne; Stowell Nicole C; Wadman Eric A; Davies Paul; Solomon Kimberly A; Newton Robert C; Trainor George L; Friedman Steven M; Decicco Carl P; Duncia John V
CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure-activity relationships.
Bioorganic & medicinal chemistry letters 2002;12(13):1785-9.
2002: Yao Wenqing; Chao Michael; Wasserman Zelda R; Liu Rui Qin; Covington Maryanne B; Newton Robert; Christ David; Wexler Ruth R; Decicco Carl P
Potent P1' biphenylmethyl substituted aggrecanase inhibitors.
Bioorganic & medicinal chemistry letters 2002;12(1):101-4.
2001: Newton R C; Solomon K A; Covington M B; Decicco C P; Haley P J; Friedman S M; Vaddi K
Biology of TACE inhibition.
Annals of the rheumatic diseases 2001;60 Suppl 3():iii25-32.
2001: Xue C B; He X; Corbett R L; Roderick J; Wasserman Z R; Liu R Q; Jaffee B D; Covington M B; Qian M; Trzaskos J M; Newton R C; Magolda R L; Wexler R R; Decicco C P
Discovery of macrocyclic hydroxamic acids containing biphenylmethyl derivatives at P1', a series of selective TNF-alpha converting enzyme inhibitors with potent cellular activity in the inhibition of TNF-alpha release.
Journal of medicinal chemistry 2001;44(21):3351-4.
2001: Yao W; Wasserman Z R; Chao M; Reddy G; Shi E; Liu R Q; Covington M B; Arner E C; Pratta M A; Tortorella M; Magolda R L; Newton R; Qian M; Ribadeneira M D; Christ D; Wexler R R; Decicco C P
Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.
Journal of medicinal chemistry 2001;44(21):3347-50.
2001: Xue C B; Voss M E; Nelson D J; Duan J J; Cherney R J; Jacobson I C; He X; Roderick J; Chen L; Corbett R L; Wang L; Meyer D T; Kennedy K; DeGradodagger W F; Hardman K D; Teleha C A; Jaffee B D; Liu R Q; Copeland R A; Covington M B; Christ D D; Trzaskos J M; Newton R C; Magolda R L; Wexler R R; Decicco C P
Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Journal of medicinal chemistry 2001;44(16):2636-60.
1999: Duan J J; Chen L; Xue C B; Wasserman Z R; Hardman K D; Covington M B; Copeland R R; Arner E C; Decicco C P
P1, P2'-linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(10):1453-8.
1999: Cherney R J; Wang L; Meyer D T; Xue C B; Arner E C; Copeland R A; Covington M B; Hardman K D; Wasserman Z R; Jaffee B D; Decicco C P
Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-alpha production.
Bioorganic & medicinal chemistry letters 1999;9(9):1279-84.
1999: Pinto D J; Batt D G; Pitts W J; Petraitis J J; Orwat M J; Wang S; Jetter J W; Sherk S R; Houghton G C; Copeland R A; Covington M B; Trzaskos J M; Magolda R L
Terphenyl cyclooxygenase-2 (COX-2) inhibitors: optimization of the central ring and o-biphenyl analogs.
Bioorganic & medicinal chemistry letters 1999;9(7):919-24.
1998: Scherle P A; Jones E A; Favata M F; Daulerio A J; Covington M B; Nurnberg S A; Magolda R L; Trzaskos J M
Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5681-6.
1998: Cherney R J; Wang L; Meyer D T; Xue C B; Wasserman Z R; Hardman K D; Welch P K; Covington M B; Copeland R A; Arner E C; DeGrado W F; Decicco C P
Macrocyclic amino carboxylates as selective MMP-8 inhibitors.
Journal of medicinal chemistry 1998;41(11):1749-51.
1998: Jacobson I C; Reddy P G; Wasserman Z R; Hardman K D; Covington M B; Arner E C; Copeland R A; Decicco C P; Magolda R L
Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in P1 as inhibitors of matrix metalloproteinases.
Bioorganic & medicinal chemistry letters 1998;8(7):837-42.
1997: Solomon K A; Covington M B; DeCicco C P; Newton R C
The fate of pro-TNF-alpha following inhibition of metalloprotease-dependent processing to soluble TNF-alpha in human monocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(9):4524-31.
1996: Brown A R; Covington M; Newton R C; Ramage R; Welch P
The total chemical synthesis of monocyte chemotactic protein-1 (MCP-1).
Journal of peptide science : an official publication of the European Peptide Society 1996;2(1):40-6.
1996: Rider N L; Pinto D; Covington M; Orwat M J; Giannaras J; Nurnberg S; Dowling R; Davis J P; Williams J M; Trzaskos J M; Copeland R A
Comparative effects of selective cyclooxygenase 1 and cyclooxygenase 2 inhibitors on myeloperoxidase and 3 alpha-hydroxysteroid dehydrogenase.
Journal of enzyme inhibition 1996;10(2):73-9.
1995: Dinchuk J E; Car B D; Focht R J; Johnston J J; Jaffee B D; Covington M B; Contel N R; Eng V M; Collins R J; Czerniak P M
Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.
Nature 1995;378(6555):406-9.
1995: Wilkerson W W; Copeland R A; Covington M; Trzaskos J M
Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition.
Journal of medicinal chemistry 1995;38(20):3895-901.
1994: Copeland R A; Williams J M; Giannaras J; Nurnberg S; Covington M; Pinto D; Pick S; Trzaskos J M
Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):11202-6.
1993: Batt D G; Goodman R; Jones D G; Kerr J S; Mantegna L R; McAllister C; Newton R C; Nurnberg S; Welch P K; Covington M B
2'-substituted chalcone derivatives as inhibitors of interleukin-1 biosynthesis.
Journal of medicinal chemistry 1993;36(10):1434-42.
1988: Huang J J; Newton R C; Rutledge S J; Horuk R; Matthew J B; Covington M; Lin Y
Characterization of murine IL-1 beta. Isolation, expression, and purification.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(11):3838-43.
1988: Newton R C; Uhl J; Covington M; Back O
The distribution and clearance of radiolabeled human interleukin-1 beta in mice.
Lymphokine research 1988;7(3):207-16.
1987: Newton R C; Covington M
The activation of human fibroblast prostaglandin E production by interleukin 1.
Cellular immunology 1987;110(2):338-49.
1987: Horuk R; Huang J J; Covington M; Newton R C
A biochemical and kinetic analysis of the interleukin-1 receptor. Evidence for differences in molecular properties of IL-1 receptors.
The Journal of biological chemistry 1987;262(34):16275-8.
1987: Huang J J; Newton R C; Horuk R; Matthew J B; Covington M; Pezzella K; Lin Y A
Muteins of human interleukin-1 that show enhanced bioactivities.
FEBS letters 1987;223(2):294-8.
1987: Huang J J; Newton R C; Pezzella K; Covington M; Tamblyn T; Rutlege S J; Gray J; Kelley M; Lin Y
High-level expression in Escherichia coli of a soluble and fully active recombinant interleukin-1 beta.
Molecular biology & medicine 1987;4(3):169-81.

Sign-in to see more

Sign-in free and Explore the Exciting World of BiomedExperts:

NetworkView

Maryanne Covington

Research Profile (preview)

Chemicals & Drugs

Concepts & Ideas

Living Beings

Occupations

Genes & Molecular Sequences

Procedures

Network (preview)

Publications

Sign in free and see...

Visualized networks:

GeoTargeted Searches:

Research Profiles:

Geonetwork of Maryanne Covington (preview)

All Publications