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James Cowan

Research Profile

Chemicals & Drugs

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TOP 3
Jeff C Joyner; Deepika Tamuly; Rachel Boyd; Ada S Cowan; W F Hodnick; James A Cowan
Antimicrobial metallopeptides with broad nuclease and ribonuclease activity.
Wenbin Qi; Jingwei Li; James A Cowan
Human ferredoxin-2 displays a unique conformational change.
Jeff C Joyner; Kevin D Keuper; James A Cowan
DNA nuclease activity of Rev-coupled transition metal chelates.

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All Publications

2013: Jeff C Joyner; Deepika Tamuly; Rachel Boyd; Ada S Cowan; W F Hodnick; James A Cowan
Antimicrobial metallopeptides with broad nuclease and ribonuclease activity.
Chemical communications (Cambridge, England) 2013;49(21):2118-20.
2013: Wenbin Qi; Jingwei Li; James A Cowan
Human ferredoxin-2 displays a unique conformational change.
Dalton transactions (Cambridge, England : 2003) 2013;42(9):3088-91.
2012: Jeff C Joyner; Kevin D Keuper; James A Cowan
DNA nuclease activity of Rev-coupled transition metal chelates.
Dalton transactions (Cambridge, England : 2003) 2012;41(21):6567-78.
2012: Seth Bradford; James A Cowan
Catalytic metallodrugs targeting HCV IRES RNA.
Chemical communications (Cambridge, England) 2012;48(25):3118-20.
2011: Jeff C Joyner; James A Cowan
Targeted cleavage of HIV RRE RNA by Rev-coupled transition metal chelates.
Journal of the American Chemical Society 2011;133(25):9912-22.
2011: Shu-pao Wu; Marzia Bellei; Sheref S Mansy; Gianantonio Battistuzzi; Marco Sola; James A Cowan
Redox chemistry of the Schizosaccharomyces pombe ferredoxin electron-transfer domain and influence of Cys to Ser substitutions.
Journal of inorganic biochemistry 2011;105(6):806-11.
2011: qi wenbin; James A Cowan
Mechanism of glutaredoxin-ISU [2Fe-2S] cluster exchange.
Chemical communications (Cambridge, England) 2011;47(17):4989-91.
2011: Anjali Patwardhan; James A Cowan
Influence of charge and structure on the coordination chemistry of copper aminoglycosides.
Dalton transactions (Cambridge, England : 2003) 2011;40(8):1795-801.
2010: Wen-I Luo; Eric Dizin; Taejin Yoon; James A Cowan
Kinetic and structural characterization of human mortalin.
Protein expression and purification 2010;72(1):75-81.
2010: Marzia Bellei; Gianantonio Battistuzzi; Shu-pao Wu; Sheref S Mansy; James A Cowan; Marco Sola
Control of reduction thermodynamics in [2Fe-2S] ferredoxins Entropy-enthalpy compensation and the influence of surface mutations.
Journal of inorganic biochemistry 2010;104(6):691-6.
2010: Kalyan C Kondapalli; Krisztina Z Bencze; Eric Dizin; James A Cowan; Timothy L Stemmler
NMR assignments of a stable processing intermediate of human frataxin.
Biomolecular NMR assignments 2010;4(1):61-4.
2010: qi wenbin; James A Cowan
A structural and functional homolog supports a general role for frataxin in cellular iron chemistry.
Chemical communications (Cambridge, England) 2010;46(5):719-21.
2009: Lalintip Hocharoen; James A Cowan
Metallotherapeutics: novel strategies in drug design.
Chemistry (Weinheim an der Bergstrasse, Germany) 2009;15(35):8670-6.
2009: Yushi Liu; James A Cowan
Iron-sulfur cluster biosynthesis: characterization of a molten globule domain in human NFU.
Biochemistry 2009;48(31):7512-8.
2009: Manunya Nuth; James A Cowan
Iron-sulfur cluster biosynthesis: characterization of IscU-IscS complex formation and a structural model for sulfide delivery to the [2Fe-2S] assembly site.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2009;14(6):829-39.
2009: Jia Huang; James A Cowan
Iron-sulfur cluster biosynthesis: role of a semi-conserved histidine.
Chemical communications (Cambridge, England) 2009;(21):3071-3.
2009: Seth Bradford; Yuta Kawarasaki; James A Cowan
Copper.Lys-Gly-His-Lys mediated cleavage of tRNA(Phe): studies of reaction mechanism and cleavage specificity.
Journal of inorganic biochemistry 2009;103(6):871-5.
2009: Yushi Liu; qi wenbin; James A Cowan
Iron-sulfur cluster biosynthesis: functional characterization of the N- and C-terminal domains of human NFU.
Biochemistry 2009;48(5):973-80.
2008: Jia Huang; Eric Dizin; James A Cowan
Mapping iron binding sites on human frataxin: implications for cluster assembly on the ISU Fe-S cluster scaffold protein.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2008;13(5):825-36.
2008: nikhil gokhale; Seth Bradford; James A Cowan
Catalytic inactivation of human carbonic anhydrase I by a metallopeptide-sulfonamide conjugate is mediated by oxidation of active site residues.
Journal of the American Chemical Society 2008;130(8):2388-9.
2007: nikhil gokhale; Seth Bradford; James A Cowan
Stimulation and oxidative catalytic inactivation of thermolysin by copper.Cys-Gly-His-Lys.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2007;12(7):981-7.
2007: Yushi Liu; James A Cowan
Iron sulfur cluster biosynthesis. Human NFU mediates sulfide delivery to ISU in the final step of [2Fe-2S] cluster assembly.
Chemical communications (Cambridge, England) 2007;(30):3192-4.
2007: Yan Jin; Mark A Lewis; nikhil gokhale; Eric C Long; James A Cowan
Influence of stereochemistry and redox potentials on the single- and double-strand DNA cleavage efficiency of Cu(II) and Ni(II) Lys-Gly-His-derived ATCUN metallopeptides.
Journal of the American Chemical Society 2007;129(26):8353-61.
2007: Yan Jin; James A Cowan
Cellular activity of Rev response element RNA targeting metallopeptides.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2007;12(5):637-44.
2007: Taejin Yoon; Eric Dizin; James A Cowan
N-terminal iron-mediated self-cleavage of human frataxin: regulation of iron binding and complex formation with target proteins.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2007;12(4):535-42.
2007: Shu-pao Wu; James A Cowan
Iron-sulfur cluster stability. Kinetics and mechanism of ligand-promoted cluster degradation.
Chemical communications (Cambridge, England) 2007;(1):82-4.
2006: nikhil gokhale; James A Cowan
Metallopeptide-promoted inactivation of angiotensin-converting enzyme and endothelin-converting enzyme 1: Toward dual-action therapeutics.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2006;11(7):937-47.
2006: Yan Jin; James A Cowan
Targeted cleavage of HIV rev response element RNA by metallopeptide complexes.
Journal of the American Chemical Society 2006;128(2):410-1.
2005: nikhil gokhale; James A Cowan
Inactivation of human angiotensin converting enzyme by copper peptide complexes containing ATCUN motifs.
Chemical communications (Cambridge, England) 2005;(47):5916-8.
2005: Yan Jin; James A Cowan
DNA cleavage by copper-ATCUN complexes. Factors influencing cleavage mechanism and linearization of dsDNA.
Journal of the American Chemical Society 2005;127(23):8408-15.
2005: Shu-pao Wu; Sheref S Mansy; James A Cowan
Iron-sulfur cluster biosynthesis. Molecular chaperone DnaK promotes IscU-bound [2Fe-2S] cluster stability and inhibits cluster transfer activity.
Biochemistry 2005;44(11):4284-93.
2004: Sheref S Mansy; James A Cowan
Iron-sulfur cluster biosynthesis: toward an understanding of cellular machinery and molecular mechanism.
Accounts of chemical research 2004;37(9):719-25.
2004: Taejin Yoon; James A Cowan
Frataxin-mediated iron delivery to ferrochelatase in the final step of heme biosynthesis.
The Journal of biological chemistry 2004;279(25):25943-6.
2004: Sheref S Mansy; Shu-pao Wu; James A Cowan
Iron-sulfur cluster biosynthesis: biochemical characterization of the conformational dynamics of Thermotoga maritima IscU and the relevance for cellular cluster assembly.
The Journal of biological chemistry 2004;279(11):10469-75.
2004: Giovanni Venturoli; Mahir D Mamedov; Sheref S Mansy; Francesco Musiani; Massimo Strocchi; Francesco Francia; Alexey Yu Semenov; James A Cowan; Stefano Ciurli
Electron transfer from HiPIP to the photooxidized tetraheme cytochrome subunit of Allochromatium vinosum reaction center: new insights from site-directed mutagenesis and computational studies.
Biochemistry 2004;43(2):437-45.
2003: Chun-An Chen; James A Cowan
Characterization of the soluble domain of the ABC7 type transporter Atm1.
The Journal of biological chemistry 2003;278(52):52681-8.
2003: Ivano Bertini; James A Cowan; Cristina Del Bianco; Claudio Luchinat; Sheref S Mansy
Thermotoga maritima IscU. Structural characterization and dynamics of a new class of metallochaperone.
Journal of molecular biology 2003;331(4):907-24.
2003: Taejin Yoon; James A Cowan
Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in ISU-type proteins.
Journal of the American Chemical Society 2003;125(20):6078-84.
2003: Shu-pao Wu; James A Cowan
Iron-sulfur cluster biosynthesis. A comparative kinetic analysis of native and Cys-substituted ISA-mediated [2Fe-2S]2+ cluster transfer to an apoferredoxin target.
Biochemistry 2003;42(19):5784-91.
2002: James A Cowan
Structural and catalytic chemistry of magnesium-dependent enzymes.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2002;15(3):225-35.
2002: Alavattam Sreedhara; James A Cowan
Structural and catalytic roles for divalent magnesium in nucleic acid biochemistry.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2002;15(3):211-23.
2002: Manunya Nuth; Taejin Yoon; James A Cowan
Iron-sulfur cluster biosynthesis: characterization of iron nucleation sites for assembly of the [2Fe-2S]2+ cluster core in IscU proteins.
Journal of the American Chemical Society 2002;124(30):8774-5.
2002: Shu-pao Wu; Gong Wu; Kristene K Surerus; James A Cowan
Iron-sulfur cluster biosynthesis. Kinetic analysis of [2Fe-2S] cluster transfer from holo ISU to apo Fd: role of redox chemistry and a conserved aspartate.
Biochemistry 2002;41(28):8876-85.
2002: Sheref S Mansy; Gong Wu; Kristene K Surerus; James A Cowan
Iron-sulfur cluster biosynthesis. Thermatoga maritima IscU is a structured iron-sulfur cluster assembly protein.
The Journal of biological chemistry 2002;277(24):21397-404.
2002: Gong Wu; Sheref S Mansy; Shu-pao Wu Sp; Kristene K Surerus; Matthew W Foster; James A Cowan
Characterization of an iron-sulfur cluster assembly protein (ISU1) from Schizosaccharomyces pombe.
Biochemistry 2002;41(15):5024-32.
2002: Gong Wu; Sheref S Mansy; Craig Hemann; Russ Hille; Kristene K Surerus; James A Cowan
Iron-sulfur cluster biosynthesis: characterization of Schizosaccharomyces pombe Isa1.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2002;7(4-5):526-32.
2002: Chun-An Chen; James A Cowan
In vivo cleavage of a target RNA by copper kanamycin A. Direct observation by a fluorescence assay.
Chemical communications (Cambridge, England) 2002;(3):196-7.
2002: Sheref S Mansy; Yong Xiong; Craig Hemann; Russ Hille; Muttaiya Sundaralingam; James A Cowan
Crystal structure and stability studies of C77S HiPIP: a serine ligated [4Fe-4S] cluster.
Biochemistry 2002;41(4):1195-201.
2001: James A Cowan
Chemical nucleases.
Current opinion in chemical biology 2001;5(6):634-42.
2001: U Puapaiboon; J Jai-Nhuknan; James A Cowan
Characterization of a multi-functional metal-mediated nuclease by MALDI-TOF mass spectrometry.
Nucleic acids research 2001;29(17):3652-6.
2001: Alavattam Sreedhara; James A Cowan
Catalytic hydrolysis of DNA by metal ions and complexes.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(4):337-47.
2001: M W Foster; S Bian; Kristene K Surerus; James A Cowan
Elucidation of a [4Fe-4S] cluster degradation pathway: rapid kinetic studies of the degradation of Chromatium vinosum HiPIP.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(3):266-74.
2001: Alavattam Sreedhara; James A Cowan
Targeted site-specific cleavage of HIV-1 viral Rev responsive element by copper aminoglycosides.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2001;6(2):166-72.
2000: James A Cowan; T Ohyama; D Wang; K Natarajan
Recognition of a cognate RNA aptamer by neomycin B: quantitative evaluation of hydrogen bonding and electrostatic interactions.
Nucleic acids research 2000;28(15):2935-42.
2000: U Puapaiboon; J Jai-nhuknan; James A Cowan
Rapid and direct sequencing of double-stranded DNA using exonuclease III and MALDI-TOF MS.
Analytical chemistry 2000;72(14):3338-41.
2000: James A Cowan; T Ohyama; K Howard; Jason W Rausch; S M Cowan; Stuart F J Le Grice
Metal-ion stoichiometry of the HIV-1 RT ribonuclease H domain: evidence for two mutually exclusive sites leads to new mechanistic insights on metal-mediated hydrolysis in nucleic acid biochemistry.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(1):67-74.
1998: K Natarajan; James A Cowan
Solution structure of a synthetic lytic peptide: the perforin amino terminus.
Chemistry & biology 1998;5(3):147-54.
1997: N Rochel; James A Cowan
Dependence of the lytic activity of the N-terminal domain of human perforin on membrane lipid composition--implications for T-cell self-preservation.
European journal of biochemistry / FEBS 1997;249(1):223-31.
1997: C B Black; James A Cowan
Inert chromium and cobalt complexes as probes of magnesium-dependent enzymes. Evaluation of the mechanistic role of the essential metal cofactor in Escherichia coli exonuclease III.
European journal of biochemistry / FEBS 1997;243(3):684-9.
1996: S Bian; Craig Hemann; R Hille; James A Cowan
Characterization of an autoreduction pathway for the [Fe4S4]3+ cluster of mutant Chromatium vinosum high-potential iron proteins. Site-directed mutagenesis studies to probe the role of phenylalanine 66 in defining the stability of the [Fe4S4] center provide evidence for oxidative degradation via a [Fe3S4] cluster.
Biochemistry 1996;35(46):14544-52.
1996: A Soriano; D Li; S Bian; A Agarwal; James A Cowan
Factors influencing redox thermodynamics and electron self-exchange for the [Fe4S4] cluster in Chromatium vinosum high potential iron protein: the role of core aromatic residues in defining cluster redox chemistry.
Biochemistry 1996;35(38):12479-86.
1995: A Agarwal; D Li; James A Cowan
Role of aromatic residues in stabilization of the [Fe4S4] cluster in high-potential iron proteins (HiPIPs): physical characterization and stability studies of Tyr-19 mutants of Chromatium vinosum HiPIP.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9440-4.
1995: D Li; C E Cottrell; James A Cowan
15N resonance assignments of oxidized and reduced Chromatium vinosum high-potential iron protein.
Journal of protein chemistry 1995;14(3):115-26.
1995: H W Huang; D Li; James A Cowan
Biostructural chemistry of magnesium. regulation of mithramycin-DNA interactions by Mg2+ coordination.
Biochimie 1995;77(9):729-38.
1994: S M Lui; A Soriano; James A Cowan
Electronic properties of the dissimilatory sulphite reductase from Desulfovibrio vulgaris (Hildenborough): comparative studies of optical spectra and relative reduction potentials for the [Fe4S4]-sirohaem prosthetic centres.
The Biochemical journal 1994;304 ( Pt 2)():441-7.
1994: S M Lui; James A Cowan
Conformational gating of the dissimilatory sulfite reductase from Desulfovibrio vulgaris (Hildenborough). Synthesis, characterization, and stopped-flow kinetics studies of 1,5-IAEDANS-labeled desulfoviridin.
Biochemistry 1994;33(37):11209-16.
1994: J Tan; A Soriano; S M Lui; James A Cowan
Functional expression and characterization of the assimilatory-type sulfite reductase from Desulfovibrio vulgaris (Hildenborough).
Archives of biochemistry and biophysics 1994;312(2):516-23.
1994: B M Wolfe; S M Lui; James A Cowan
Desulfoviridin, a multimeric-dissimilatory sulfite reductase from Desulfovibrio vulgaris (Hildenborough). Purification, characterization, kinetics and EPR studies.
European journal of biochemistry / FEBS 1994;223(1):79-89.
1994: H W Huang; James A Cowan
Metallobiochemistry of the magnesium ion. Characterization of the essential metal-binding site in Escherichia coli ribonuclease H.
European journal of biochemistry / FEBS 1994;219(1-2):253-60.
1994: S M Lui; James A Cowan
A direct spectrophotometric method for monitoring the kinetics of T-cell cytolysis.
Biochimie 1994;76(5):452-4.
1993: A Agarwal; J Tan; M Eren; A Tevelev; S M Lui; James A Cowan
Synthesis, cloning and expression of a synthetic gene for high potential iron protein from Chromatium vinosum.
Biochemical and biophysical research communications 1993;197(3):1357-62.
1993: James A Cowan; H W Huang; L Y Hsu
Sequence selective coordination of Mg2+(aq) to DNA.
Journal of inorganic biochemistry 1993;52(2):121-9.
1993: James A Cowan
Metallobiochemistry of RNA. Co(NH3)6(3+) as a probe for Mg2+(aq) binding sites.
Journal of inorganic biochemistry 1993;49(3):171-5.
1991: J Tan; L R Helms; Richard P Swenson; James A Cowan
Primary structure of the assimilatory-type sulfite reductase from Desulfovibrio vulgaris (Hildenborough): cloning and nucleotide sequence of the reductase gene.
Biochemistry 1991;30(41):9900-7.
1991: J Tan; James A Cowan
Enzymatic redox chemistry: a proposed reaction pathway for the six-electron reduction of SO3(2-) to S2- by the assimilatory-type sulfite reductase from Desulfovibrio vulgaris (Hildenborough).
Biochemistry 1991;30(36):8910-7.
1990: S S Reid; James A Cowan
Biostructural chemistry of magnesium ion: characterization of the weak binding sites on tRNA(Phe)(yeast). Implications for conformational change and activity.
Biochemistry 1990;29(25):6025-32.
1990: James A Cowan; Marco Sola
1H NMR studies of oxidized high-potential iron protein from Chromatium vinosum. Nuclear Overhauser effect measurements.
Biochemistry 1990;29(23):5633-7.
1990: J A Tan; James A Cowan
Coordination and redox properties of a novel triheme cytochrome from Desulfovibrio vulgaris (Hildenborough).
Biochemistry 1990;29(20):4886-92.
1989: Marco Sola; James A Cowan; H B Gray
1H NMR characterization of Chromatium gracile high-potential iron protein and its ruthenium-modified derivatives. Modulation of the reduction potentials in low- and high-potential [Fe4S4] ferredoxins.
Biochemistry 1989;28(12):5261-8.
1988: James A Cowan; R K Upmacis; DN Beratan; José N Onuchic; H B Gray
Long-range electron transfer in myoglobin.
Annals of the New York Academy of Sciences 1988;550():68-84.