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Kenneth Cowan

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Ryan H Kolb; Phu T Cao; Kenneth H Cowan; Patrick M Greer; Ying Yan
ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation.
Ying Yan; Phu T Cao; Patrick M Greer; Ryan H Kolb; Kenneth H Cowan
RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation.
Ying Yan; P T Cao; P M Greer; E S Nagengast; R H Kolb; M C Mumby; Kenneth H Cowan
Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response.

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2012: Ryan H Kolb; Phu T Cao; Kenneth H Cowan; Patrick M Greer; Ying Yan
ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation.
PloS one 2012;7(11):e50281.
2012: Ying Yan; Phu T Cao; Patrick M Greer; Ryan H Kolb; Kenneth H Cowan
RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation.
Breast cancer research : BCR 2012;14(2):R60.
2010: Ying Yan; P T Cao; P M Greer; E S Nagengast; R H Kolb; M C Mumby; Kenneth H Cowan
Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response.
Oncogene 2010;29(30):4317-29.
2009: Scott M Stoeger; Kenneth H Cowan
Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines.
Cancer chemotherapy and pharmacology 2009;63(5):807-18.
2009: Gina L Razidlo; Heidi Johnson; Scott M Stoeger; Kenneth H Cowan; Tadayoshi Bessho; Robert Lewis
KSR1 is required for cell cycle reinitiation following DNA damage.
The Journal of biological chemistry 2009;284(11):6705-15.
2008: Ying Yan; Claudine P Black; Phu T Cao; Jamie L Haferbier; Ryan H Kolb; Rebecca S Spieker; Alexandra M Ristow; Kenneth H Cowan
Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1.
Cancer research 2008;68(13):5113-21.
2007: Ying Yan; C P Black; Kenneth H Cowan
Irradiation-induced G2/M checkpoint response requires ERK1/2 activation.
Oncogene 2007;26(32):4689-98.
2006: Rebecca Cook; Laura S Caskey; Melissa Sandahl; Debra M Hunter; Carty Husted; Karen Strunk; Carolyn I Sartor; William A Rearick; Wesley McCall; Magdalene K Sgagias; Kenneth H Cowan; Henry Earp
Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1.
Molecular and cellular biology 2006;26(17):6412-24.
2006: Ani V Das; Xing Zhao; Jackson James; Min Kim; Kenneth H Cowan; Iqbal Ahmad
Neural stem cells in the adult ciliary epithelium express GFAP and are regulated by Wnt signaling.
Biochemical and biophysical research communications 2006;339(2):708-16.
2005: Hesham Basma; Hesham El Refaey; Magdalene K Sgagias; Kenneth H Cowan; Xu Luo; Pi-Wan Cheng
BCL-2 antisense and cisplatin combination treatment of MCF-7 breast cancer cells with or without functional p53.
Journal of biomedical science 2005;12(6):999-1011.
2005: Zhengtang Chen; Michelle L Varney; Matthew W Backora; Kenneth H Cowan; Joyce C Solheim; James Edward Talmadge; Rakesh K Singh
Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival.
Cancer research 2005;65(19):9004-11.
2005: Min Kim; Ying Yan; Robert L Kortum; Scott M Stoeger; Magdalene K Sgagias; Kwangmoon Lee; Robert Lewis; Kenneth H Cowan
Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity.
Cancer research 2005;65(10):3986-92.
2005: Ying Yan; Rebecca S Spieker; Min Kim; Scott M Stoeger; Kenneth H Cowan
BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation.
Oncogene 2005;24(20):3285-96.
2004: Magdalene K Sgagias; Kay-Uwe Wagner; Brad Hamik; Scott M Stoeger; Rebecca Spieker; L Julie Huber; Lewis A Chodosh; Kenneth H Cowan
Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS.
Cell cycle (Georgetown, Tex.) 2004;3(11):1451-6.
2004: Min Kim; Ying Yan; Kwangmoon Lee; Magdalene K Sgagias; Kenneth H Cowan
Ectopic expression of von Hippel-Lindau tumor suppressor induces apoptosis in 786-O renal cell carcinoma cells and regresses tumor growth of 786-O cells in nude mouse.
Biochemical and biophysical research communications 2004;320(3):945-50.
2004: Min Kim; Magdalene K Sgagias; Xiyun Deng; Yun-Jin Jung; Toshiki Rikiyama; Kwangmoon Lee; Michel Ouellette; Kenneth H Cowan
Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression.
Biochemical and biophysical research communications 2004;320(1):138-44.
2004: Fumiaki Nozawa; Atsushi Itami; Murat Saruc; Min Kim; Jens Standop; Kathleen S Picha; Kenneth H Cowan; Parviz M Pour
The combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) and Genistein is effective in inhibiting pancreatic cancer growth.
Pancreas 2004;29(1):45-52.
2003: Kuniharu Yamamoto; Yu Katayose; Masanori Suzuki; Michiaki Unno; Tsuyoshi Sasaki; Masamichi Mizuma; Satoru Shiraso; Hideo Ohtuka; Kenneth H Cowan; Prem Seth; Seiki Matsuno
Adenovirus expressing p27KIP1 induces apoptosis against cholangiocarcinoma cells by triggering Fas ligand on the cell surface.
Hepato-gastroenterology 2003;50(54):1847-53.
2003: Jo Anne Zujewski; Jennifer Eng-Wong; Joyce A O'Shaughnessy; David Venzon; Catherine Chow; David N Danforth; David R Kohler; Georgia Cusack; David Riseberg; Kenneth H Cowan
A pilot study of dose intense doxorubicin and cyclophosphamide followed by infusional paclitaxel in high-risk primary breast cancer.
Breast cancer research and treatment 2003;81(1):41-51.
2003: David N Danforth; Kenneth H Cowan; Rosemary M Altemus; Maria Merino; Catherine Chow; Arlene Berman; Usha Chaudhry; Craig Shriver; Seth M Steinberg; Jo Anne Zujewski
Preoperative FLAC/granulocyte-colony-stimulating factor chemotherapy for stage II breast cancer: a prospective randomized trial.
Annals of surgical oncology 2003;10(6):635-44.
2002: Ying Yan; John P Haas; Min Kim; Magdalene K Sgagias; Kenneth H Cowan
BRCA1-induced apoptosis involves inactivation of ERK1/2 activities.
The Journal of biological chemistry 2002;277(36):33422-30.
2002: Xiyun Deng; Min Kim; Didier Vandier; Yun-Jin Jung; Toshiki Rikiyama; Magdalene K Sgagias; Merrill Goldsmith; Kenneth H Cowan
Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin.
Biochemical and biophysical research communications 2002;296(4):792-8.
2002: Ronit I Yarden; Sherly Pardo-Reoyo; Magdalene K Sgagias; Kenneth H Cowan; Lawrence C Brody
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage.
Nature genetics 2002;30(3):285-9.
2002: Min Kim; Heth R Turnquist; John Jackson; Magdalene K Sgagias; Ying Yan; Maokai Gong; Michael Dean; J Graham Sharp; Kenneth H Cowan
The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(1):22-8.
2001: JA Lawrence; Peter Charles Adamson; R Caruso; Catherine Chow; David Kleiner; RF Murphy; David J Venzon; M Shovlin; MH Noone; Maria Merino; Kenneth H Cowan; M Kaiser; Joyce A O'Shaughnessy; Jo Anne Zujewski
Phase I clinical trial of alitretinoin and tamoxifen in breast cancer patients: toxicity, pharmacokinetic, and biomarker evaluations.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(10):2754-63.
2000: Didier Vandier; Olivier Rixe; Francois Besnard; Min Kim; Toshiki Rikiyama; M Goldsmith; M Brenner; Alain Gouyette; Kenneth H Cowan
Inhibition of glioma cells in vitro and in vivo using a recombinant adenoviral vector containing an astrocyte-specific promoter.
Cancer gene therapy 2000;7(8):1120-6.
2000: Min Kim; Yu Katayose; L Rojanala; S Shah; Magdalene K Sgagias; L Jang; Yun-Jin Jung; S H Lee; Sang-Gu Hwang; Kenneth H Cowan
Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein.
Cell death and differentiation 2000;7(8):706-11.
2000: D Paul; M H Qazilbash; K Song; H Xu; B K Sinha; Johnson Ming-Yu Liu; Kenneth H Cowan
Construction of a recombinant adeno-associated virus (rAAV) vector expressing murine interleukin-12 (IL-12).
Cancer gene therapy 2000;7(2):308-15.
2000: Jo Anne Zujewski; ID Horak; CJ Bol; R Woestenborghs; Charlie Bowden; David W End; V K Piotrovsky; J Chiao; Robert T Belly; A Todd; William Kopp; David R Kohler; Catherine Chow; MH Noone; Frances T Hakim; G Larkin; Ronald E Gress; Robert B Nussenblatt; A B Kremer; Kenneth H Cowan
Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(4):927-41.
2000: Timothy K MacLachlan; K Somasundaram; Magdalene K Sgagias; Y Shifman; Ruth J Muschel; Kenneth H Cowan; Wafik S El-Deiry
BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression.
The Journal of biological chemistry 2000;275(4):2777-85.
2000: BA Conley; Joyce A O'Shaughnessy; Sheila A Prindiville; J Lawrence; Catherine Chow; E Jones; Maria J Merino; Muriel I Kaiser-Kupfer; Rafael C Caruso; MJ Podgor; Barry Goldspiel; David Venzon; David N Danforth; Suhlan Wu; MH Noone; J Goldstein; Kenneth H Cowan; Jo Anne Zujewski
Pilot trial of the safety, tolerability, and retinoid levels of N-(4-hydroxyphenyl) retinamide in combination with tamoxifen in patients at high risk for developing invasive breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(2):275-83.
2000: Turid Knutsen; V Koneti Rao; Thomas Ried; Lyn A Mickley; E Schneider; K Miyake; B Michael Ghadimi; Hesed Padilla-Nash; Svetlana Pack; Lee M Greenberger; Kenneth H Cowan; Michael Dean; Tito Fojo; Susan Bates
Amplification of 4q21-q22 and the MXR gene in independently derived mitoxantrone-resistant cell lines.
Genes, chromosomes & cancer 2000;27(1):110-6.
1999: K Somasundaram; Timothy K MacLachlan; Timothy F Burns; Magdalene K Sgagias; Kenneth H Cowan; Barbara L Weber; Wafik S El-Deiry
BRCA1 signals ARF-dependent stabilization and coactivation of p53.
Oncogene 1999;18(47):6605-14.
1999: Jo Anne Zujewski; L Pai; Lalage M Wakefield; Ruthann M Giusti; F A Dorr; C Flanders; R Caruso; M Kaiser; L Goodman; Maria Merino; M Gossard; M A Noone; Andrea M Denicoff; David Venzon; Kenneth H Cowan; Joyce A O'Shaughnessy
Tamoxifen and fenretinide in women with metastatic breast cancer.
Breast cancer research and treatment 1999;57(3):277-83.
1999: Kenneth H Cowan; Jeffrey A Moscow; H Huang; Jo Anne Zujewski; Joyce A O'Shaughnessy; Brian P Sorrentino; Kenneth Hines; Charles Carter; E Schneider; Georgia Cusack; MH Noone; Cynthia Dunbar; S Steinberg; Wyndham Wilson; Barry Goldspiel; Elizabeth J Read; Susan F Leitman; Kevin T McDonagh; Catherine Chow; Andrea Abati; Y Chiang; Y N Chang; Michael M Gottesman; Ira Pastan; Arthur W Nienhuis
Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(7):1619-28.
1999: Jeffrey A Moscow; H Huang; Charles Carter; Kenneth Hines; Jo Anne Zujewski; Georgia Cusack; Catherine Chow; David Venzon; Brian P Sorrentino; Y Chiang; Barry Goldspiel; Susan F Leitman; Elizabeth J Read; Andrea Abati; Michael M Gottesman; Ira Pastan; Stephanie Sellers; Cynthia Dunbar; Kenneth H Cowan
Engraftment of MDR1 and NeoR gene-transduced hematopoietic cells after breast cancer chemotherapy.
Blood 1999;94(1):52-61.
1999: M Gong; Kenneth H Cowan; J Gudas; Jeffrey A Moscow
Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1).
Gene 1999;233(1-2):21-31.
1999: AN Rakkar; Yu Katayose; Min Kim; Clifford L Craig; E Ohri; Zhuqing Li; Kenneth H Cowan; Pankaj Seth
A novel adenoviral vector expressing human Fas/CD95/APO-1 enhances p53-mediated apoptosis.
Cell death and differentiation 1999;6(4):326-33.
1998: Min Kim; Yu Katayose; Qingdi Q Li; AN Rakkar; Zhuqing Li; Sang-Gu Hwang; D Katayose; Jane Trepel; Kenneth H Cowan; Pankaj Seth
Recombinant adenovirus expressing Von Hippel-Lindau-mediated cell cycle arrest is associated with the induction of cyclin-dependent kinase inhibitor p27Kip1.
Biochemical and biophysical research communications 1998;253(3):672-7.
1998: AN Rakkar; Zhuqing Li; Yu Katayose; Min Kim; Kenneth H Cowan; Pankaj Seth
Adenoviral expression of the cyclin-dependent kinase inhibitor p27Kip1: a strategy for breast cancer gene therapy.
Journal of the National Cancer Institute 1998;90(23):1836-8.
1998: Gretchen N Schwartz; M K Warren; S W Rothwell; Jo Anne Zujewski; D C Halverson; Kenneth H Cowan; A Tolcher; Joyce A O'Shaughnessy; Ronald E Gress
Post-chemotherapy and cytokine pretreated marrow stromal cell layers suppress hematopoiesis from normal donor CD34+ cells.
Bone marrow transplantation 1998;22(5):457-68.
1998: Zhuqing Li; AN Rakkar; Yu Katayose; Min Kim; N Shanmugam; Shefali Srivastava; J W Moul; D G McLeod; Kenneth H Cowan; Pankaj Seth
Efficacy of multiple administrations of a recombinant adenovirus expressing wild-type p53 in an immune-competent mouse tumor model.
Gene therapy 1998;5(5):605-13.
1998: T Hoshino; Y Z Jiang; D Dunn; D Paul; M Qazilbash; Kenneth H Cowan; J Wang; J Barrett; Johnson Ming-Yu Liu
Transfection of interleukin-12 cDNAs into tumor cells induces cytotoxic immune responses against native tumor: implications for tumor vaccination.
Cancer gene therapy 1998;5(3):150-7.
1998: David N Danforth; Jo Anne Zujewski; Joyce A O'Shaughnessy; D Riseberg; Seth M Steinberg; N McAtee; MH Noone; Catherine Chow; U Chaudhry; Marc Lippman; J Jacobson; P Okunieff; Kenneth H Cowan
Selection of local therapy after neoadjuvant chemotherapy in patients with stage IIIA,B breast cancer.
Annals of surgical oncology 1998;5(2):150-8.
1998: Clifford L Craig; Min Kim; E Ohri; R Wersto; D Katayose; Zhuqing Li; Young Hun Choi; B Mudahar; Shefali Srivastava; Pankaj Seth; Kenneth H Cowan
Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells.
Oncogene 1998;16(2):265-72.
1997: Yu Katayose; Min Kim; AN Rakkar; Zhuqing Li; Kenneth H Cowan; Pankaj Seth
Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27.
Cancer research 1997;57(24):5441-5.
1997: Pankaj Seth; D Katayose; Zhuqing Li; Min Kim; R Wersto; Clifford L Craig; N Shanmugam; E Ohri; B Mudahar; AN Rakkar; Padmaja Kodali; Kenneth H Cowan
A recombinant adenovirus expressing wild type p53 induces apoptosis in drug-resistant human breast cancer cells: a gene therapy approach for drug-resistant cancers.
Cancer gene therapy 1997;4(6):383-90.
1997: Frances T Hakim; R Cepeda; S Kaimei; CRYSTAL MACKALL; N McAtee; Jo Anne Zujewski; Kenneth H Cowan; Ronald E Gress
Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells.
Blood 1997;90(9):3789-98.
1997: Jeffrey A Moscow; T Connolly; Timothy G Myers; C C Cheng; KD Paull; Kenneth H Cowan
Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines.
International journal of cancer. Journal international du cancer 1997;72(1):184-90.
1997: M H Qazilbash; Xiao Xiao; Pankaj Seth; Kenneth H Cowan; Christopher E Walsh
Cancer gene therapy using a novel adeno-associated virus vector expressing human wild-type p53.
Gene therapy 1997;4(7):675-82.
1997: RV Emmons; S Doren; Jo Anne Zujewski; M Cottler-Fox; Charles S Carter; Kenneth Hines; Joyce A O'Shaughnessy; Susan F Leitman; J J Greenblatt; Kenneth H Cowan; Cynthia E Dunbar
Retroviral gene transduction of adult peripheral blood or marrow-derived CD34+ cells for six hours without growth factors or on autologous stroma does not improve marking efficiency assessed in vivo.
Blood 1997;89(11):4040-6.
1997: Clifford L Craig; R Wersto; Min Kim; E Ohri; Zhuqing Li; D Katayose; Su-Jun Lee; Jane Trepel; Kenneth H Cowan; Pankaj Seth
A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells.
Oncogene 1997;14(19):2283-9.
1997: A W Tolcher; Joyce A O'Shaughnessy; R B Weiss; Jo Anne Zujewski; R C Myhand; E Schneider; Frances T Hakim; Ronald E Gress; Barry Goldspiel; MH Noone; L R Brewster; M R Gossard; Kenneth H Cowan
A phase I study of topotecan followed sequentially by doxorubicin in patients with advanced malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(5):755-60.
1997: M Gong; J Yess; T Connolly; S Percy Ivy; T Ohnuma; Kenneth H Cowan; Jeffrey A Moscow
Molecular mechanism of antifolate transport-deficiency in a methotrexate-resistant MOLT-3 human leukemia cell line.
Blood 1997;89(7):2494-9.
1997: Zhuqing Li; N Shanmugam; D Katayose; B Huber; Shefali Srivastava; Kenneth H Cowan; Pankaj Seth
Enzyme/prodrug gene therapy approach for breast cancer using a recombinant adenovirus expressing Escherichia coli cytosine deaminase.
Cancer gene therapy 1997;4(2):113-7.
1997: Jeffrey A Moscow; E Schneider; S Percy Ivy; Kenneth H Cowan
Multidrug resistance.
Cancer chemotherapy and biological response modifiers 1997;17():139-77.
1997: Cynthia E Dunbar; John F Tisdale; JM Yu; T Soma; Jo Anne Zujewski; David M Bodine; Stephanie Sellers; Kenneth H Cowan; R Donahue; RV Emmons
Transduction of hematopoietic stem cells in humans and in nonhuman primates.
Stem cells (Dayton, Ohio) 1997;15 Suppl 1():135-9; discussion 139-40.
1996: Frances T Hakim; R Childs; J Balow; Kenneth H Cowan; Jo Anne Zujewski; Ronald E Gress
Development of paroxysmal nocturnal hemoglobinuria after chemotherapy.
Blood 1996;88(12):4725-6.
1996: J M Gudas; Hoang Nguyen; T Li; L Sadzewicz; Robert W Robey; K Wosikowski; Kenneth H Cowan
Drug-resistant breast cancer cells frequently retain expression of a functional wild-type p53 protein.
Carcinogenesis 1996;17(7):1417-27.
1996: I Weinberg; S Majewski; A Weisenberger; A Markowitz; Luigi Aloj; L Majewski; D Danforth; J Mulshine; Kenneth H Cowan; Jo Anne Zujewski; Catherine Chow; E Jones; V Chang; Wendie A Berg; J Frank
Preliminary results for positron emission mammography: real-time functional breast imaging in a conventional mammography gantry.
European journal of nuclear medicine 1996;23(7):804-6.
1996: M K Sgagias; CA Nieroda; J R Yannelli; Kenneth H Cowan; David N Danforth
Upregulation of DF3, in association with ICAM-1 and MHC class II by IFN-gamma in short-term human mammary carcinoma cell cultures.
Cancer biotherapy & radiopharmaceuticals 1996;11(3):177-85.
1996: J M Gudas; T Li; Hoang Nguyen; D Jensen; F J Rauscher; Kenneth H Cowan
Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1996;7(6):717-23.
1996: A W Tolcher; Kenneth H Cowan; D Solomon; Frederick P Ognibene; Barry Goldspiel; R Chang; MH Noone; A M Denicoff; C S Barnes; M R Gossard; Patricia A Fetsch; Stacey L Berg; FRANK BALIS; D J Venzon; Joyce A O'Shaughnessy
Phase I crossover study of paclitaxel with r-verapamil in patients with metastatic breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(4):1173-84.
1996: Pankaj Seth; Ulrich Brinkmann; Gretchen N Schwartz; D Katayose; Ronald E Gress; Kenneth H Cowan
Adenovirus-mediated gene transfer to human breast tumor cells: an approach for cancer gene therapy and bone marrow purging.
Cancer research 1996;56(6):1346-51.
1996: Joyce A O'Shaughnessy; A Tolcher; D Riseberg; David Venzon; Jo Anne Zujewski; MH Noone; M Gossard; D Danforth; J Jacobson; V Chang; Barry Goldspiel; P Keegan; R Giusti; Kenneth H Cowan
Prospective, randomized trial of 5-fluorouracil, leucovorin, doxorubicin, and cyclophosphamide chemotherapy in combination with the interleukin-3/granulocyte-macrophage colony-stimulating factor (GM-CSF) fusion protein (PIXY321) versus GM-CSF in patients with advanced breast cancer.
Blood 1996;87(6):2205-11.
1996: J S Fisherman; Kenneth H Cowan; MH Noone; A Denicoff; S Berg; David G Poplack; FRANK BALIS; David Venzon; M McCabe; Barry Goldspiel; Catherine Chow; Frederick P Ognibene; Joyce A O'Shaughnessy
Phase I/II study of 72-hour infusional paclitaxel and doxorubicin with granulocyte colony-stimulating factor in patients with metastatic breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(3):774-82.
1996: Gretchen N Schwartz; Frances T Hakim; Jo Anne Zujewski; J M Szabo; R Cepada; D Riseberg; M K Warren; CRYSTAL MACKALL; A Setzer; MH Noone; Kenneth H Cowan; Joyce A O'Shaughnessy; Ronald E Gress
Early suppressive effects of chemotherapy and cytokine treatment on committed versus primitive haemopoietic progenitors in patient bone marrow.
British journal of haematology 1996;92(3):537-47.
1996: M K Warren; Jo Anne Zujewski; W L Rose; J M Szabo; Joyce A O'Shaughnessy; D C Halverson; Kenneth H Cowan; Ronald E Gress; Gretchen N Schwartz
Early suppressive effects of chemotherapy on recovery of bone marrow megakaryocyte precursors: possible relationship to platelet recovery.
Stem cells (Dayton, Ohio) 1996;14 Suppl 1():31-7.
1996: J J Chiu; M K Sgagias; Kenneth H Cowan
Interleukin 6 acts as a paracrine growth factor in human mammary carcinoma cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(1):215-21.
1996: Jeffrey A Moscow; E Schneider; Kenneth H Cowan
Multidrug resistance.
Cancer chemotherapy and biological response modifiers 1996;16():111-31.
1996: A W Tolcher; Kenneth H Cowan; MH Noone; A M Denicoff; David R Kohler; Barry Goldspiel; C S Barnes; M McCabe; M R Gossard; Jo Anne Zujewski; Joyce A O'Shaughnessy
Phase I study of paclitaxel in combination with cyclophosphamide and granulocyte colony-stimulating factor in metastatic breast cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1996;14(1):95-102.
1995: Joyce A O'Shaughnessy; D J Venzon; M Gossard; MH Noone; A Denicoff; A Tolcher; D Danforth; J Jacobson; P Keegan; L Miller; Catherine Chow; Barry Goldspiel; Kenneth H Cowan
A phase I study of sequential versus concurrent interleukin-3 and granulocyte-macrophage colony-stimulating factor in advanced breast cancer patients treated with FLAC (5-fluorouracil, leucovorin, doxorubicin, cyclophosphamide) chemotherapy.
Blood 1995;86(8):2913-21.
1995: J M Gudas; Hoang Nguyen; T Li; Kenneth H Cowan
Hormone-dependent regulation of BRCA1 in human breast cancer cells.
Cancer research 1995;55(20):4561-5.
1995: D Katayose; R Wersto; Kenneth H Cowan; Pankaj Seth
Consequences of p53 gene expression by adenovirus vector on cell cycle arrest and apoptosis in human aortic vascular smooth muscle cells.
Biochemical and biophysical research communications 1995;215(2):446-51.
1995: D Katayose; R Wersto; Kenneth H Cowan; Pankaj Seth
Effects of a recombinant adenovirus expressing WAF1/Cip1 on cell growth, cell cycle, and apoptosis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(10):1207-12.
1995: C J Yang; J K Horton; Kenneth H Cowan; E Schneider
Cross-resistance to camptothecin analogues in a mitoxantrone-resistant human breast carcinoma cell line is not due to DNA topoisomerase I alterations.
Cancer research 1995;55(18):4004-9.
1995: Jeffrey A Moscow; M Gong; R He; M K Sgagias; K H Dixon; Sarah L Anzick; Paul S Meltzer; Kenneth H Cowan
Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transport-deficient, methotrexate-resistant human breast cancer cells.
Cancer research 1995;55(17):3790-4.
1995: D Katayose; J Gudas; Hoang Nguyen; Shefali Srivastava; Kenneth H Cowan; Pankaj Seth
Cytotoxic effects of adenovirus-mediated wild-type p53 protein expression in normal and tumor mammary epithelial cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(8):889-97.
1995: Stacey L Berg; A Tolcher; Joyce A O'Shaughnessy; A M Denicoff; MH Noone; Frederick P Ognibene; Kenneth H Cowan; FRANK BALIS
Effect of R-verapamil on the pharmacokinetics of paclitaxel in women with breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(8):2039-42.
1995: J Gudas; Hoang Nguyen; T Li; D Hill; Kenneth H Cowan
Effects of cell cycle, wild-type p53 and DNA damage on p21CIP1/Waf1 expression in human breast epithelial cells.
Oncogene 1995;11(2):253-61.
1995: P Kolachana; Kenneth H Cowan; A Denicoff; E C Jones; P L Choyke
Chemotherapy-induced changes in uterine volume: CT study.
Journal of computer assisted tomography 1995;19(4):592-5.
1995: Jeffrey A Moscow; Patrick G Johnston; D Cole; David G Poplack; Kenneth H Cowan
Characterization of cross-resistance to methotrexate in a human breast cancer cell line selected for resistance to melphalan.
Biochemical pharmacology 1995;49(8):1069-78.
1995: J A Jacobson; David N Danforth; Kenneth H Cowan; T d'Angelo; Seth M Steinberg; Lori J Pierce; Marc Lippman; A S Lichter; E Glatstein; P Okunieff
Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer.
The New England journal of medicine 1995;332(14):907-11.
1995: E Schneider; H Yamazaki; B K Sinha; Kenneth H Cowan
Buthionine sulphoximine-mediated sensitisation of etoposide-resistant human breast cancer MCF7 cells overexpressing the multidrug resistance-associated protein involves increased drug accumulation.
British journal of cancer 1995;71(4):738-43.
1995: J M Gudas; R C Klein; M Oka; Kenneth H Cowan
Posttranscriptional regulation of the c-myb proto-oncogene in estrogen receptor-positive breast cancer cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(2):235-43.
1995: M E Goldsmith; J M Gudas; E Schneider; Kenneth H Cowan
Wild type p53 stimulates expression from the human multidrug resistance promoter in a p53-negative cell line.
The Journal of biological chemistry 1995;270(4):1894-8.
1995: Lalage M Wakefield; John J Letterio; T Chen; David Danielpour; R S Allison; L H Pai; A M Denicoff; MH Noone; Kenneth H Cowan; Joyce A O'Shaughnessy
Transforming growth factor-beta1 circulates in normal human plasma and is unchanged in advanced metastatic breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(1):129-36.
1995: J M Gudas; Hoang Nguyen; R C Klein; D Katayose; Pankaj Seth; Kenneth H Cowan
Differential expression of multiple MDM2 messenger RNAs and proteins in normal and tumorigenic breast epithelial cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(1):71-80.
1995: A W Tolcher; R M Giusti; Joyce A O'Shaughnessy; Kenneth H Cowan
Arterial thrombosis associated with granulocyte-macrophage colony-stimulating factor (GM-CSF) administration in breast cancer patients treated with dose-intensive chemotherapy: a report of two cases.
Cancer investigation 1995;13(2):188-92.
1995: Joyce A O'Shaughnessy; Kenneth H Cowan
Current status of paclitaxel in the treatment of breast cancer.
Breast cancer research and treatment 1995;33(1):27-37.
1995: E Schneider; Kenneth H Cowan; H Bader; S Toomey; Gretchen N Schwartz; Judith E Karp; P J Burke; S H Kaufmann
Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia.
Blood 1995;85(1):186-93.
1994: Jeffrey A Moscow; L Schmidt; D T Ingram; JR Gnarra; B Johnson; Kenneth H Cowan
Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung cancer.
Carcinogenesis 1994;15(12):2769-73.
1994: C Theodossiou; Glenn S Kroog; S Ettinghausen; A Tolcher; Kenneth H Cowan; Joyce A O'Shaughnessy
Acute arterial thrombosis in a patient with breast cancer after chemotherapy with 5-fluorouracil, doxorubicin, leucovorin, cyclophosphamide, and interleukin-3.
Cancer 1994;74(10):2808-10.
1994: Joyce A O'Shaughnessy; J S Fisherman; Kenneth H Cowan
Combination paclitaxel (Taxol) and doxorubicin therapy for metastatic breast cancer.
Seminars in oncology 1994;21(5 Suppl 8):19-23.
1994: Jeffrey A Moscow; R He; J M Gudas; Kenneth H Cowan
Utilization of multiple polyadenylation signals in the human RHOA protooncogene.
Gene 1994;144(2):229-36.
1994: Joyce A O'Shaughnessy; Kenneth H Cowan; A W Nienhuis; Kevin T McDonagh; Brian P Sorrentino; Cynthia E Dunbar; Y Chiang; W Wilson; Barry Goldspiel; David R Kohler
Retroviral mediated transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer.
Human gene therapy 1994;5(7):891-911.
1994: Cynthia E Dunbar; David M Bodine; Brian P Sorrentino; R Donahue; Kevin T McDonagh; M Cottler-Fox; Joyce A O'Shaughnessy; Kenneth H Cowan; Charles Carter; S Doren
Gene transfer into hematopoietic cells. Implications for cancer therapy.
Annals of the New York Academy of Sciences 1994;716():216-24; discussion 224-7.
1994: Charles S Morrow; M Nakagawa; M E Goldsmith; M J Madden; Kenneth H Cowan
Reversible transcriptional activation of mdr1 by sodium butyrate treatment of human colon cancer cells.
The Journal of biological chemistry 1994;269(14):10739-46.
1994: J M Gudas; M Oka; F Diella; Jane Trepel; Kenneth H Cowan
Expression of wild-type p53 during the cell cycle in normal human mammary epithelial cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(3):295-304.
1994: Stacey L Berg; Kenneth H Cowan; FRANK BALIS; J S Fisherman; A M Denicoff; M Hillig; David G Poplack; Joyce A O'Shaughnessy
Pharmacokinetics of taxol and doxorubicin administered alone and in combination by continuous 72-hour infusion.
Journal of the National Cancer Institute 1994;86(2):143-5.
1994: Lori J Pierce; Maria J Merino; T D'Angelo; Edward Barker; L Gilbert; Kenneth H Cowan; Seth M Steinberg; E Glatstein
Is c-erb B-2 a predictor for recurrent disease in early stage breast cancer?
International journal of radiation oncology, biology, physics 1994;28(2):395-403.
1994: K H Dixon; B C Lanpher; J Chiu; K Kelley; Kenneth H Cowan
A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells.
The Journal of biological chemistry 1994;269(1):17-20.
1994: Jeffrey A Moscow; R He; JR Gnarra; Turid Knutsen; Y Weng; W P Zhao; J Whang-Peng; W Marston Linehan; Kenneth H Cowan
Examination of human tumors for rhoA mutations.
Oncogene 1994;9(1):189-94.
1994: E Schneider; J K Horton; C H Yang; M Nakagawa; Kenneth H Cowan
Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance.
Cancer research 1994;54(1):152-8.
1994: Jeffrey A Moscow; E Schneider; Kenneth H Cowan
Multidrug resistance.
Cancer chemotherapy and biological response modifiers 1994;15():99-129.
1993: Charles S Morrow; Kenneth H Cowan
Antineoplastic drug resistance and breast cancer.
Annals of the New York Academy of Sciences 1993;698():289-312.
1993: Joyce A O'Shaughnessy; Kenneth H Cowan
Dose-intensive therapy for breast cancer.
JAMA : the journal of the American Medical Association 1993;270(17):2089-92.
1993: Jeffrey A Moscow; Christine A Swanson; Kenneth H Cowan
Decreased melphalan accumulation in a human breast cancer cell line selected for resistance to melphalan.
British journal of cancer 1993;68(4):732-7.
1993: Joyce A O'Shaughnessy; Kenneth H Cowan; W Wilson; G Bryant; Barry Goldspiel; R Gress; A W Nienhuis; Cynthia Dunbar; Brian P Sorrentino; F Marc Stewart
Pilot study of high dose ICE (ifosfamide, carboplatin, etoposide) chemotherapy and autologous bone marrow transplant (ABMT) with neoR-transduced bone marrow and peripheral blood stem cells in patients with metastatic breast cancer.
Human gene therapy 1993;4(3):331-54.
1993: Stacey L Berg; D M Savarese; FRANK BALIS; A M Denicoff; M Hillig; Joyce A O'Shaughnessy; David G Poplack; Kenneth H Cowan
Pharmacokinetics of piroxantrone in a phase I trial of piroxantrone and granulocyte-colony stimulating factor.
Cancer research 1993;53(11):2587-90.
1993: M J Madden; Charles S Morrow; M Nakagawa; M E Goldsmith; C R Fairchild; Kenneth H Cowan
Identification of 5' and 3' sequences involved in the regulation of transcription of the human mdr1 gene in vivo.
The Journal of biological chemistry 1993;268(11):8290-7.
1993: Cynthia E Dunbar; A W Nienhuis; F Marc Stewart; Peter J Quesenberry; Joyce A O'Shaughnessy; Kenneth H Cowan; M Cottler-Fox; Susan F Leitman; S Goodman; Brian P Sorrentino
Amendment to clinical research projects. Genetic marking with retroviral vectors to study the feasibility of stem cell gene transfer and the biology of hematopoietic reconstitution after autologous transplantation in multiple myeloma, chronic myelogenous leukemia, or metastatic breast cancer.
Human gene therapy 1993;4(2):205-22.
1993: Koong-Nah Chung; Y Saikawa; T H Paik; K H Dixon; T Mulligan; Kenneth H Cowan; P C Elwood
Stable transfectants of human MCF-7 breast cancer cells with increased levels of the human folate receptor exhibit an increased sensitivity to antifolates.
The Journal of clinical investigation 1993;91(4):1289-94.
1993: M E Goldsmith; M J Madden; Charles S Morrow; Kenneth H Cowan
A Y-box consensus sequence is required for basal expression of the human multidrug resistance (mdr1) gene.
The Journal of biological chemistry 1993;268(8):5856-60.
1993: B C Pestalozzi; G A Sotos; P L Choyke; J S Fisherman; Kenneth H Cowan; Joyce A O'Shaughnessy
Typhlitis resulting from treatment with taxol and doxorubicin in patients with metastatic breast cancer.
Cancer 1993;71(5):1797-800.
1993: N Ben-Baruch; A M Denicoff; Barry Goldspiel; Joyce A O'Shaughnessy; Kenneth H Cowan
Phase II study of fazarabine (NSC 281272) in patients with metastatic colon cancer.
Investigational new drugs 1993;11(1):71-4.
1993: P G Johnston; D Kleiner; Kenneth H Cowan
Fazarabine: a report of response in a patient with multiply relapsed embryonal cell carcinoma.
American journal of clinical oncology 1993;16(1):34-7.
1993: Charles S Morrow; Kenneth H Cowan
Drug resistance and cancer.
Advances in experimental medicine and biology 1993;330():287-305.
1993: Jeffrey A Moscow; E Schneider; Kenneth H Cowan
Multidrug resistance.
Cancer chemotherapy and biological response modifiers 1993;14():98-117.
1993: J S Fisherman; M McCabe; MH Noone; Frederick P Ognibene; Barry Goldspiel; D J Venzon; Kenneth H Cowan; Joyce A O'Shaughnessy
Phase I study of Taxol, doxorubicin, plus granulocyte-colony stimulating factor in patients with metastatic breast cancer.
Journal of the National Cancer Institute. Monographs 1993;(15):189-94.
1992: K H Dixon; T Mulligan; Koong-Nah Chung; P C Elwood; Kenneth H Cowan
Effects of folate receptor expression following stable transfection into wild type and methotrexate transport-deficient ZR-75-1 human breast cancer cells.
The Journal of biological chemistry 1992;267(33):24140-7.
1992: M Nakagawa; E Schneider; K H Dixon; J Horton; K Kelley; C Morrow; Kenneth H Cowan
Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells.
Cancer research 1992;52(22):6175-81.
1992: Wyndham H Wilson; V Jain; G Bryant; Kenneth H Cowan; Charles Carter; M Cottler-Fox; Barry Goldspiel; Seth M Steinberg; Dan Longo; Robert Wittes
Phase I and II study of high-dose ifosfamide, carboplatin, and etoposide with autologous bone marrow rescue in lymphomas and solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1992;10(11):1712-22.
1992: Charles S Morrow; J Chiu; Kenneth H Cowan
Posttranscriptional control of glutathione S-transferase pi gene expression in human breast cancer cells.
The Journal of biological chemistry 1992;267(15):10544-50.
1992: Jeffrey A Moscow; Charles S Morrow; R He; G T Mullenbach; Kenneth H Cowan
Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1).
The Journal of biological chemistry 1992;267(9):5949-58.
1992: Alan J Townsend; C P Tu; Kenneth H Cowan
Expression of human mu or alpha class glutathione S-transferases in stably transfected human MCF-7 breast cancer cells: effect on cellular sensitivity to cytotoxic agents.
Molecular pharmacology 1992;41(2):230-6.
1992: Lori J Pierce; Marc Lippman; N Ben-Baruch; S Swain; Joyce A O'Shaughnessy; J L Bader; D Danforth; David Venzon; Kenneth H Cowan
The effect of systemic therapy on local-regional control in locally advanced breast cancer.
International journal of radiation oncology, biology, physics 1992;23(5):949-60.
1992: K Straus; A Lichter; Marc Lippman; D Danforth; S Swain; Kenneth H Cowan; E deMoss; H MacDonald; S Steinberg; T d'Angelo
Results of the National Cancer Institute early breast cancer trial.
Journal of the National Cancer Institute. Monographs 1992;(11):27-32.
1992: Jeffrey A Moscow; Charles S Morrow; Kenneth H Cowan
Multidrug resistance.
Cancer chemotherapy and biological response modifiers 1992;13():91-114.
1992: Elizabeth J Read; Joyce A O'Shaughnessy; M Y Yu; M Cottler-Fox; A M Denicoff; Kenneth H Cowan; Ronald E Gress
Flow cytometric quantitation of circulating hematopoietic progenitor cells in breast cancer patients on chemotherapy.
Progress in clinical and biological research 1992;377():523-30.
1991: Alan J Townsend; Charles S Morrow; B K Sinha; Kenneth H Cowan
Selenium-dependent glutathione peroxidase expression is inversely related to estrogen receptor content of human breast cancer cells.
Cancer communications 1991;3(8):265-70.
1991: G Yu; S Ahmad; A Aquino; C R Fairchild; Jane Trepel; S Ohno; K Suzuki; T Tsuruo; Kenneth H Cowan; R I Glazer
Transfection with protein kinase C alpha confers increased multidrug resistance to MCF-7 cells expressing P-glycoprotein.
Cancer communications 1991;3(6):181-9.
1991: C R Fairchild; Kenneth H Cowan
Keynote address: multidrug resistance: a pleiotropic response to cytotoxic drugs.
International journal of radiation oncology, biology, physics 1991;20(2):361-7.
1991: Brian Leyland-Jones; Alan J Townsend; C P Tu; Kenneth H Cowan; M E Goldsmith
Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human alpha class glutathione S-transferase gene.
Cancer research 1991;51(2):587-94.
1991: K H Dixon; Jane Trepel; S C Eng; Kenneth H Cowan
Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line.
Cancer communications 1991;3(12):357-65.
1990: C R Fairchild; Jeffrey A Moscow; E E O'Brien; Kenneth H Cowan
Multidrug resistance in cells transfected with human genes encoding a variant P-glycoprotein and glutathione S-transferase-pi.
Molecular pharmacology 1990;37(6):801-9.
1990: Charles S Morrow; Kenneth H Cowan
Multidrug resistance associated with altered topoisomerase II activity--topoisomerases II as targets for rational drug design.
Journal of the National Cancer Institute 1990;82(8):638-9.
1990: Charles S Morrow; M E Goldsmith; Kenneth H Cowan
Regulation of human glutathione S-transferase pi gene transcription: influence of 5'-flanking sequences and trans-activating factors which recognize AP-1-binding sites.
Gene 1990;88(2):215-25.
1990: A Surbone; Harry Ford; James A Kelley; N Ben-Baruch; R V Thomas; R Fine; Kenneth H Cowan
Phase I and pharmacokinetic study of arabinofuranosyl-5-azacytosine (fazarabine, NSC 281272).
Cancer research 1990;50(4):1220-5.
1990: Charles S Morrow; Kenneth H Cowan
Glutathione S-transferases and drug resistance.
Cancer cells (Cold Spring Harbor, N.Y. : 1989) 1990;2(1):15-22.
1989: Alan J Townsend; M E Goldsmith; C B Pickett; Kenneth H Cowan
Isolation, characterization, and expression in Escherichia coli of two murine Mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2).
The Journal of biological chemistry 1989;264(36):21582-90.
1989: Jeffrey A Moscow; Alan J Townsend; Kenneth H Cowan
Elevation of pi class glutathione S-transferase activity in human breast cancer cells by transfection of the GST pi gene and its effect on sensitivity to toxins.
Molecular pharmacology 1989;36(1):22-8.
1989: Jeffrey A Moscow; C R Fairchild; M J Madden; D T Ransom; H S Wieand; E E O'Brien; David G Poplack; J Cossman; Charles E Myers; Kenneth H Cowan
Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors.
Cancer research 1989;49(6):1422-8.
1989: Charles S Morrow; Kenneth H Cowan; M E Goldsmith
Structure of the human genomic glutathione S-transferase-pi gene.
Gene 1989;75(1):3-11.
1989: P J Vickers; M J Dufresne; Kenneth H Cowan
Relation between cytochrome P450IA1 expression and estrogen receptor content of human breast cancer cells.
Molecular endocrinology (Baltimore, Md.) 1989;3(1):157-64.
1988: S Percy Ivy; A Tulpule; C R Fairchild; S D Averbuch; Charles E Myers; Daniel W Nebert; W M Baird; Kenneth H Cowan
Altered regulation of P-450IA1 expression in a multidrug-resistant MCF-7 human breast cancer cell line.
The Journal of biological chemistry 1988;263(35):19119-25.
1988: P J Vickers; Robert B Dickson; R Shoemaker; Kenneth H Cowan
A multidrug-resistant MCF-7 human breast cancer cell line which exhibits cross-resistance to antiestrogens and hormone-independent tumor growth in vivo.
Molecular endocrinology (Baltimore, Md.) 1988;2(10):886-92.
1988: Jeffrey A Moscow; Alan J Townsend; M E Goldsmith; J Whang-Peng; P J Vickers; R Poisson; S Legault-Poisson; Charles E Myers; Kenneth H Cowan
Isolation of the human anionic glutathione S-transferase cDNA and the relation of its gene expression to estrogen-receptor content in primary breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(17):6518-22.
1988: M E Goldsmith; Kenneth H Cowan
Modulation of a human dihydrofolate reductase minigene following release from amino acid deprivation involves both 5' and 3' nucleotide sequences.
Molecular pharmacology 1988;33(4):378-83.
1988: Jeffrey A Moscow; Kenneth H Cowan
Multidrug resistance.
Journal of the National Cancer Institute 1988;80(1):14-20.
1987: G C Yeh; S J Occhipinti; Kenneth H Cowan; B A Chabner; Charles E Myers
Adriamycin resistance in human tumor cells associated with marked alteration in the regulation of the hexose monophosphate shunt and its response to oxidant stress.
Cancer research 1987;47(22):5994-9.
1987: C R Fairchild; S Percy Ivy; T Rushmore; G Lee; P Koo; M E Goldsmith; Charles E Myers; E Farber; Kenneth H Cowan
Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(21):7701-5.
1987: C R Fairchild; S Percy Ivy; C S Kao-Shan; J Whang-Peng; N Rosen; Mark Israel; Peter W Melera; Kenneth H Cowan; M E Goldsmith
Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells.
Cancer research 1987;47(19):5141-8.
1987: B K Sinha; Aspandiar G Katki; G Batist; Kenneth H Cowan; Charles E Myers
Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action.
Biochemistry 1987;26(13):3776-81.
1987: B K Sinha; Aspandiar G Katki; G Batist; Kenneth H Cowan; Charles E Myers
Adriamycin-stimulated hydroxyl radical formation in human breast tumor cells.
Biochemical pharmacology 1987;36(6):793-6.
1986: G Batist; A Tulpule; B K Sinha; Aspandiar G Katki; Charles E Myers; Kenneth H Cowan
Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.
The Journal of biological chemistry 1986;261(33):15544-9.
1982: Kenneth H Cowan; Marc Lippman
Steroid receptors in breast cancer.
Archives of internal medicine 1982;142(2):363-6.
1981: Kenneth H Cowan; Marc Lippman
Recent progress in breast cancer management. Combined modality (adjuvant) therapy.
Archives of internal medicine 1981;141(8):1055-9.