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Adrienne Cox
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Research Profile (preview)
Chemicals & Drugs
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Network (preview)
34
Der, Channing
8
Fiordalisi, James
6
Buss, Janice
6
Rusyn, Elena
5
Khosravi-Far, Roya
5
Berzat, Anastacia
4
Grana, Theresa M.
4
Keller, Patricia J.
4
Philips, Mark
3
Reynolds, ER
3
Shutes, Adam
3
Bivona, Trever
3
Chenette, Emily
3
Clark, Geoffrey
2
Coffey, Robert
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Geonetwork of Adrienne Cox (preview)
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All Publications
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2009: Madigan James P; Bodemann Brian O; Brady Donita C; Dewar Brian J; Keller Patricia J; Leitges Michael; Philips Mark R; Ridley Anne J; Der Channing J; Cox Adrienne D
Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.
The Biochemical journal 2009;424(1):153-61.
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2009: Brady Donita C; Alan Jamie K; Madigan James P; Fanning Alan S; Cox Adrienne D
The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis.
Molecular and cellular biology 2009;29(4):1035-49.
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2008: Roberts Patrick J; Mitin Natalia; Keller Patricia J; Chenette Emily J; Madigan James P; Currin Rachel O; Cox Adrienne D; Wilson Oswald; Kirschmeier Paul; Der Channing J
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.
The Journal of biological chemistry 2008;283(37):25150-63.
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2008: Reiner David J; González-Pérez Vanessa; Der Channing J; Cox Adrienne D
Use of Caenorhabditis elegans to evaluate inhibitors of Ras function in vivo.
Methods in enzymology 2008;439():425-49.
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2007: Philips Mark R; Cox Adrienne D
Geranylgeranyltransferase I as a target for anti-cancer drugs.
The Journal of clinical investigation 2007;117(5):1223-5.
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2006: Fiordalisi James J; Keller Patricia J; Cox Adrienne D
PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility.
Cancer research 2006;66(6):3153-61.
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2006: Bivona Trever G; Quatela Steven E; Bodemann Brian O; Ahearn Ian M; Soskis Michael J; Mor Adam; Miura John; Wiener Heidi H; Wright Latasha; Saba Shahryar G; Yim Duke; Fein Adam; Pérez de Castro Ignacio; Li Chi; Thompson Craig B; Cox Adrienne D; Philips Mark R
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.
Molecular cell 2006;21(4):481-93.
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2006: Berzat Anastacia C; Brady Donita C; Fiordalisi James J; Cox Adrienne D
Using inhibitors of prenylation to block localization and transforming activity.
Methods in enzymology 2006;407():575-97.
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2006: Shutes Adam; Berzat Anastacia C; Chenette Emily J; Cox Adrienne D; Der Channing J
Biochemical analyses of the Wrch atypical Rho family GTPases.
Methods in enzymology 2006;406():11-26.
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2005: Keller Patricia J; Gable Christyn M; Wing Michele R; Cox Adrienne D
Rac3-mediated transformation requires multiple effector pathways.
Cancer research 2005;65(21):9883-90.
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2005: Keller Patricia J; Fiordalisi James J; Berzat Anastacia C; Cox Adrienne D
Visual monitoring of post-translational lipid modifications using EGFP-GTPase probes in live cells.
Methods (San Diego, Calif.) 2005;37(2):131-37.
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2005: Capell Brian C; Erdos Michael R; Madigan James P; Fiordalisi James J; Varga Renee; Conneely Karen N; Gordon Leslie B; Der Channing J; Cox Adrienne D; Collins Francis S
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12879-84.
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2005: Berzat Anastacia C; Buss Janice E; Chenette Emily J; Weinbaum Carolyn A; Shutes Adam; Der Channing J; Minden Audrey; Cox Adrienne D
Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif.
The Journal of biological chemistry 2005;280(38):33055-65.
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2005: Lim Kian-Huat; Baines Antonio T; Fiordalisi James J; Shipitsin Michail; Feig Larry A; Cox Adrienne D; Der Channing J; Counter Christopher M
Activation of RalA is critical for Ras-induced tumorigenesis of human cells.
Cancer cell 2005;7(6):533-45.
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2004: Shutes Adam; Berzat Anastacia C; Cox Adrienne D; Der Channing J
Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase.
Current biology : CB 2004;14(22):2052-6.
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2004: Solski Patricia A; Wilder Rhonda S; Rossman Kent L; Sondek John; Cox Adrienne D; Campbell Sharon L; Der Channing J
Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation.
The Journal of biological chemistry 2004;279(24):25226-33.
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2003: Cox Adrienne D; Der Channing J
The dark side of Ras: regulation of apoptosis.
Oncogene 2003;22(56):8999-9006.
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2003: Joyce Patricia L; Cox Adrienne D
Rac1 and Rac3 are targets for geranylgeranyltransferase I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling.
Cancer research 2003;63(22):7959-67.
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2003: Grana Theresa M; Sartor Carolyn I; Cox Adrienne D
Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance.
Cancer research 2003;63(22):7807-14.
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2003: Fiordalisi James J; Johnson Ronald L; Weinbaum Carolyn A; Sakabe Kaoru; Chen Zhui; Casey Patrick J; Cox Adrienne D
High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors.
The Journal of biological chemistry 2003;278(43):41718-27.
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2003: Bivona Trever G; Pérez De Castro Ignacio; Ahearn Ian M; Grana Theresa M; Chiu Vi K; Lockyer Peter J; Cullen Peter J; Pellicer Angel; Cox Adrienne D; Philips Mark R
Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.
Nature 2003;424(6949):694-8.
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2002: Cox Adrienne D; Der Channing J
Ras family signaling: therapeutic targeting.
Cancer biology & therapy 2002;1(6):599-606.
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2002: Cox Adrienne D; Der Channing J
Farnesyltransferase inhibitors: promises and realities.
Current opinion in pharmacology 2002;2(4):388-93.
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2002: Grana Theresa M; Rusyn Elena V; Zhou Hong; Sartor Carolyn I; Cox Adrienne D
Ras mediates radioresistance through both phosphatidylinositol 3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-independent signaling pathways.
Cancer research 2002;62(14):4142-50.
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2002: Hansen Malene; Rusyn Elena V; Hughes Paul E; Ginsberg Mark H; Cox Adrienne D; Willumsen Berthe M
R-Ras C-terminal sequences are sufficient to confer R-Ras specificity to H-Ras.
Oncogene 2002;21(28):4448-61.
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2002: Chiu Vi K; Bivona Trever; Hach Angela; Sajous J Bernard; Silletti Joseph; Wiener Heidi; Johnson Ronald L; Cox Adrienne D; Philips Mark R
Ras signalling on the endoplasmic reticulum and the Golgi.
Nature cell biology 2002;4(5):343-50.
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2002: Fiordalisi James J; Holly Stephen P; Johnson Ronald L; Parise Leslie V; Cox Adrienne D
A distinct class of dominant negative Ras mutants: cytosolic GTP-bound Ras effector domain mutants that inhibit Ras signaling and transformation and enhance cell adhesion.
The Journal of biological chemistry 2002;277(13):10813-23.
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2001: Yamashina S; Konno A; Wheeler M D; Rusyn I; Rusyn E V; Cox A D; Thurman R G
Endothelial cells contain a glycine-gated chloride channel.
Nutrition and cancer 2001;40(2):197-204.
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2001: Cox A D
Farnesyltransferase inhibitors: potential role in the treatment of cancer.
Drugs 2001;61(6):723-32.
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2001: Fiordalisi J J; Johnson R L; Ulkü A S; Der C J; Cox A D
Mammalian expression vectors for Ras family proteins: generation and use of expression constructs to analyze Ras family function.
Methods in enzymology 2001;332():3-36.
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2000: Rusyn E V; Reynolds E R; Shao H; Grana T M; Chan T O; Andres D A; Cox A D
Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.
Oncogene 2000;19(41):4685-94.
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2000: Yin M; Rusyn I; Schoonhoven R; Graves L M; Rusyn E V; Li X; Li F; Cox A D; Harding T W; Bunzendahl H; Swenberg J A; Thurman R G
Inhibition of chronic rejection of aortic allografts by dietary glycine.
Transplantation 2000;69(5):773-80.
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1999: Sizemore N; Cox A D; Barnard J A; Oldham S M; Reynolds E R; Der C J; Coffey R J
Pharmacological inhibition of Ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor-related peptides.
Gastroenterology 1999;117(3):567-76.
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1999: Keely P J; Rusyn E V; Cox A D; Parise L V
R-Ras signals through specific integrin alpha cytoplasmic domains to promote migration and invasion of breast epithelial cells.
The Journal of cell biology 1999;145(5):1077-88.
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1998: Oldham S M; Cox A D; Reynolds E R; Sizemore N S; Coffey R J; Der C J
Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade.
Oncogene 1998;16(20):2565-73.
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1997: Cox A D; Der C J
Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?
Biochimica et biophysica acta 1997;1333(1):F51-71.
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1997: Huff S Y; Quilliam L A; Cox A D; Der C J
R-Ras is regulated by activators and effectors distinct from those that control Ras function.
Oncogene 1997;14(2):133-43.
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1996: Willumsen B M; Cox A D; Solski P A; Der C J; Buss J E
Novel determinants of H-Ras plasma membrane localization and transformation.
Oncogene 1996;13(9):1901-9.
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1996: Graham S M; Vojtek A B; Huff S Y; Cox A D; Clark G J; Cooper J A; Der C J
TC21 causes transformation by Raf-independent signaling pathways.
Molecular and cellular biology 1996;16(11):6132-40.
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1996: Bernhard E J; Kao G; Cox A D; Sebti S M; Hamilton A D; Muschel R J; McKenna W G
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts.
Cancer research 1996;56(8):1727-30.
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1995: Overbeck A F; Brtva T R; Cox A D; Graham S M; Huff S Y; Khosravi-Far R; Quilliam L A; Solski P A; Der C J
Guanine nucleotide exchange factors: activators of Ras superfamily proteins.
Molecular reproduction and development 1995;42(4):468-76.
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1995: Lerner E C; Qian Y; Blaskovich M A; Fossum R D; Vogt A; Sun J; Cox A D; Der C J; Hamilton A D; Sebti S M
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.
The Journal of biological chemistry 1995;270(45):26802-6.
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1995: Zohn I E; Yu H; Li X; Cox A D; Earp H S
Angiotensin II stimulates calcium-dependent activation of c-Jun N-terminal kinase.
Molecular and cellular biology 1995;15(11):6160-8.
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1995: Wang H G; Millan J A; Cox A D; Der C J; Rapp U R; Beck T; Zha H; Reed J C
R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.
The Journal of cell biology 1995;129(4):1103-14.
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1995: Clark G J; Cox A D; Graham S M; Der C J
Biological assays for Ras transformation.
Methods in enzymology 1995;255():395-412.
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1995: Cox A D; Solski P A; Jordan J D; Der C J
Analysis of Ras protein expression in mammalian cells.
Methods in enzymology 1995;255():195-220.
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1995: Cox A D
Mutation and analysis of prenylation signal sequences.
Methods in enzymology 1995;250():105-21.
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1994: Cox A D; Brtva T R; Lowe D G; Der C J
R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells.
Oncogene 1994;9(11):3281-8.
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1994: Graham S M; Cox A D; Drivas G; Rush M G; D'Eustachio P; Der C J
Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation.
Molecular and cellular biology 1994;14(6):4108-15.
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1994: Cox A D; Der C J
Biological assays for cellular transformation.
Methods in enzymology 1994;238():277-94.
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1993: Cox A D; Graham S M; Solski P A; Buss J E; Der C J
The carboxyl-terminal CXXX sequence of Gi alpha, but not Rab5 or Rab11, supports Ras processing and transforming activity.
The Journal of biological chemistry 1993;268(16):11548-52.
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1992: Khosravi-Far R; Clark G J; Abe K; Cox A D; McLain T; Lutz R J; Sinensky M; Der C J
Ras (CXXX) and Rab (CC/CXC) prenylation signal sequences are unique and functionally distinct.
The Journal of biological chemistry 1992;267(34):24363-8.
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1992: Kato K; Cox A D; Hisaka M M; Graham S M; Buss J E; Der C J
Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6403-7.
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1992: Khosravi-Far R; Cox A D; Kato K; Der C J
Protein prenylation: key to ras function and cancer intervention?
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(7):461-9.
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1992: Cox A D; Hisaka M M; Buss J E; Der C J
Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein.
Molecular and cellular biology 1992;12(6):2606-15.
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1991: Plutner H; Cox A D; Pind S; Khosravi-Far R; Bourne J R; Schwaninger R; Der C J; Balch W E
Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.
The Journal of cell biology 1991;115(1):31-43.
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1991: Khosravi-Far R; Lutz R J; Cox A D; Conroy L; Bourne J R; Sinensky M; Balch W E; Buss J E; Der C J
Isoprenoid modification of rab proteins terminating in CC or CXC motifs.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(14):6264-8.
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1990: Johnson D R; Cox A D; Solski P A; Devadas B; Adams S P; Leimgruber R M; Heuckeroth R O; Buss J E; Gordon J I
Functional analysis of protein N-myristoylation: metabolic labeling studies using three oxygen-substituted analogs of myristic acid and cultured mammalian cells provide evidence for protein-sequence-specific incorporation and analog-specific redistribution.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8511-5.
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