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Emanuele Cozzi

Research Profile

Chemicals & Drugs

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Physiology

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Stéphanie Le Bas-Bernardet; David Minault; N Poirier; Karine Renaudin; L Scobie; Jean-Paul Soulillou; X Tillou; Bernard Vanhove; Béatrice Charreau; M Chatelais; P J Cowan; Emanuele Cozzi; C Crossan; A J F d'Apice; J Devallière; N Dilek; C Galli; J Hervouet; Gilles Blancho
Xenotransplantation of galactosyl-transferase knockout, CD55, CD59, CD39, and fucosyl-transferase transgenic pig kidneys into baboons.
Henk-Jan Schuurman; Harold T Smith; Emanuele Cozzi
Tolerability of cyclosphosphamide and methotrexate induction immunosuppression in nonhuman primates.
Tuan T Lam; Bernard Hausen; Laurie Hook; Macy Lau; John Higgins; Uwe Christians; Wolfgang Jacobsen; Muhammad Baluom; Rudolf O Duthaler; Andreas G Katopodis; Gilberto Chavez; Emanuele Cozzi; Richard Harrison; Henk-Jan Schuurman; Dominic C Borie; randall morris
The effect of soluble complement receptor type 1 on acute humoral xenograft rejection in hDAF-transgenic pig-to-primate life-supporting kidney xenografts.

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All Publications

2011: Stéphanie Le Bas-Bernardet; David Minault; N Poirier; Karine Renaudin; L Scobie; Jean-Paul Soulillou; X Tillou; Bernard Vanhove; Béatrice Charreau; M Chatelais; P J Cowan; Emanuele Cozzi; C Crossan; A J F d'Apice; J Devallière; N Dilek; C Galli; J Hervouet; Gilles Blancho
Xenotransplantation of galactosyl-transferase knockout, CD55, CD59, CD39, and fucosyl-transferase transgenic pig kidneys into baboons.
Transplantation proceedings 2011;43(9):3426-30.
2005: Henk-Jan Schuurman; Harold T Smith; Emanuele Cozzi
Tolerability of cyclosphosphamide and methotrexate induction immunosuppression in nonhuman primates.
Toxicology 2005;213(1-2):1-12.
2005: Tuan T Lam; Bernard Hausen; Laurie Hook; Macy Lau; John Higgins; Uwe Christians; Wolfgang Jacobsen; Muhammad Baluom; Rudolf O Duthaler; Andreas G Katopodis; Gilberto Chavez; Emanuele Cozzi; Richard Harrison; Henk-Jan Schuurman; Dominic C Borie; randall morris
The effect of soluble complement receptor type 1 on acute humoral xenograft rejection in hDAF-transgenic pig-to-primate life-supporting kidney xenografts.
Xenotransplantation 2005;12(1):20-9.
2004: Henk-Jan Schuurman; Harold T Smith; Emanuele Cozzi
Reference values for clinical chemistry and clinical hematology parameters in baboons.
Xenotransplantation 2004;11(6):511-6.
2003: Joanna Ashton-Chess; Jean-Christian Roussel; Rafael Manez; Carmen Ruiz; Anne Moreau; Emanuele Cozzi; David Minault; Jean-Paul Soulillou; Gilles Blancho
Cellular participation in delayed xenograft rejection of hCD55 transgenic pig hearts by baboons.
Xenotransplantation 2003;10(5):446-53.
2003: Emanuele Cozzi; Conrad Vial; Daniel J Ostlie; Bhatti Farah; Gilberto Chavez; Kenneth G C Smith; John R Bradley; Sathia Thiru; Hugh F S Davies; John Wallwork; David J G White; Martin Goddard; Peter J Friend
Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts.
Xenotransplantation 2003;10(4):300-10.
2002: Andreas G Katopodis; Richard G Warner; Rudolf O Duthaler; Markus B Streiff; Armin Bruelisauer; Olivier Kretz; Birgit Dorobek; Elke Persohn; Hendrik Andres; Alain Schweitzer; Gebhard Thoma; Willy Kinzy; Valerie QUESNIAUX; Emanuele Cozzi; Hugh F S Davies; Rafael Mañez; David White
Removal of anti-Galalpha1,3Gal xenoantibodies with an injectable polymer.
The Journal of clinical investigation 2002;110(12):1869-77.
2002: Tuan T Lam; Bernard Hausen; E Squiers; Emanuele Cozzi; randall morris
Cyclophosphamide-induced postoperative anemia in cynomolgus monkey recipients of hDAF-transgenic pig organ xenografts.
Transplantation proceedings 2002;34(5):1451-2.
2002: Henk-Jan Schuurman; Gilda Pino-Chavez; M James Phillips; Lucy Thomas; David J G White; Emanuele Cozzi
Incidence of hyperacute rejection in pig-to-primate transplantation using organs from hDAF-transgenic donors.
Transplantation 2002;73(7):1146-51.
2002: Andrew C Richards; Hugh F S Davies; Megan L McLaughlin; Laura S Copeman; Beverly J Holmes; Gabriela Dos Santos Cruz; Sandhya Bycroft; Gilberto Chavez; David J G White; Henk-Jan Schuurman; Emanuele Cozzi
Serum anti-pig antibodies as potential indicators of acute humoral xenograft rejection in pig-to-cynomolgus monkey kidney transplantation.
Transplantation 2002;73(6):881-9.
2002: Beverly J Holmes; Andrew C Richards; Michel Awwad; Laura S Copeman; Megan L McLaughlin; Emanuele Cozzi; Henk-Jan Schuurman; Hugh F S Davies
Anti-pig antibody levels in naïve baboons and cynomolgus monkeys.
Xenotransplantation 2002;9(2):135-47.
2002: CG Palenciano; Bertha Segura; P Ramirez; R Chavez; Vicente Munitiz; MG Cayuela; Francisco Acosta; T Sansano; M Juliana Majado; A Muñoz; O Hernandez; Gilda Pino-Chavez; M Loba; J Yelamos; MR Gago; AS Vizcaino; H Asensi; F Marin; A Rubio; Teodomiro Fuente; A Rios; M Montoya; Ricardo Robles; FS Bueno; Jose Manuel Rodriguez; F Navarro; JB Cabezuelo; Emanuele Cozzi; D J G White; Pascual Parrilla
Acid-base and electrolyte disturbances in an experimental model of orthotopic liver xenotransplantation from pig to baboon after graft reperfusion: differences between h-DAF livers and unmodified livers.
Transplantation proceedings 2002;34(1):325-6.
2002: JB Cabezuelo; P Ramirez; R Chavez; M Juliana Majado; Vicente Munitiz; A Muñoz; Q Hernandez; C G-Palenciano; G Pino-Chávez; M Loba; José Yélamos; AS Vizcaino; MG Cayuela; Bertha Segura; F Marin; A Rubio; Teodomiro Fuente; MR Gago; Antonio Ríos; M Montoya; A Esteban; FS Bueno; Ricardo Robles; Emanuele Cozzi; D J G White; Pascual Parrilla
Assessment of renal function during the postoperative period following liver xenotransplantation from transgenic pig to baboon.
Transplantation proceedings 2002;34(1):321-2.
2002: Elizabeth F McInnes; Ruth F Jarrett; Gillian Langford; Carl Atkinson; Jo Horsley; Martin J Goddard; Emanuele Cozzi; Henk-Jan Schuurman
Posttransplant lymphoproliferative disorder associated with primate gamma-herpesvirus in cynomolgus monkeys used in pig-to-primate renal xenotransplantation and primate renal allotransplantation.
Transplantation 2002;73(1):44-52.
2001: B Soin; Kenneth G C Smith; A Zaidi; Emanuele Cozzi; John R Bradley; Daniel J Ostlie; ANDREW LOCKHART; David J G White; Peter J Friend
Physiological aspects of pig-to-primate renal xenotransplantation.
Kidney international 2001;60(4):1592-7.
2001: Beverly J Holmes; Andrew Richards; M McLaughlin; G Cruz; Laura S Copeman; S Bycroft; Henk-Jan Schuurman; David J G White; H Davies; Emanuele Cozzi
Antibody responses in early graft rejection in pig-to-primate renal xenotransplantation.
Transplantation proceedings 2001;33(1-2):717-8.
2001: Martin Loss; Burkhard Vangerow; Jan Schmidtko; Robert Kunz; Jens M Hecker; Carsten Schröder; H Rückholt; Franz-Josef Kaup; B Soin; Emanuele Cozzi; Siegfried Piepenbrock; Jürgen Klempnauer; David J G White; Michael Winkler
Acute vascular rejection of h-DAF transgenic porcine kidneys in immunosuppressed cynomolgus monkeys is associated with systemic and intragraft complement activation.
Transplantation proceedings 2001;33(1-2):715.
2000: Emanuele Cozzi; B Soin; B Holmes; D White
Genetic engineering of the donor as an approach to clinical xenotransplantation.
Transplantation proceedings 2000;32(8):2701-3.
2000: P Ramirez; R Chavez; M Juliana Majado; Vicente Munitiz; A Muñoz; Q Hernandez; CG Palenciano; Gilda Pino-Chavez; M Loba; Alfredo Minguela; J Yelamos; MR Gago; AS Vizcaino; H Asensi; MG Cayuela; Bertha Segura; F Marin; A Rubio; Teodomiro Fuente; Ricardo Robles; FS Bueno; T Sansano; Francisco Acosta; Jose Manuel Rodriguez; F Navarro; JB Cabezuelo; Emanuele Cozzi; David J G White; RY Calne; Pascual Parrilla
Life-supporting human complement regulator decay accelerating factor transgenic pig liver xenograft maintains the metabolic function and coagulation in the nonhuman primate for up to 8 days.
Transplantation 2000;70(7):989-98.
2000: Martin Loss; Burkhard Vangerow; Jan Schmidtko; Robert Kunz; A Jalali; H Arends; Michael Przemeck; H Rückholt; Martin Leuwer; Franz-Josef Kaup; S Rensing; Emanuele Cozzi; David J G White; Jürgen Klempnauer; Michael Winkler
Acute vascular rejection is associated with systemic complement activation in a pig-to-primate kidney xenograft model.
Xenotransplantation 2000;7(3):186-96.
2000: Martin Loss; Michael Przemeck; Jan Schmidtko; H Arends; Robert Kunz; K Jäger; A Jalali; S Rensing; J Kaup; Emanuele Cozzi; David J G White; Jürgen Klempnauer; Michael Winkler
Long-term survival of cynomolgus monkeys following pig-to-primate kidney xenotransplantation using h-DAF transgenic donor organs.
Transplantation proceedings 2000;32(5):1095-6.
2000: S Masroor; Emanuele Cozzi; B Soin; Conrad Vial; Gilberto Chavez; Kenneth G C Smith; John R Bradley; David J G White; Peter J Friend
Absence of hyperacute rejection and preservation of function in HDAF transgenic pig kidneys exposed to prolonged cold ischaemia.
Transplantation proceedings 2000;32(5):965-6.
2000: D Quan; C Bravery; G Chavez; Andrew Richards; G Cruz; Laura S Copeman; C Atkinson; Beverly J Holmes; H Davies; Emanuele Cozzi; D White
Identification, detection, and in vitro characterization of cynomolgus monkey natural killer cells in delayed xenograft rejection of hDAF transgenic porcine renal xenografts.
Transplantation proceedings 2000;32(5):936-7.
2000: Rafael Manez; Fabian Crespo; E Gonzalez; Alberto Centeno; Alberto Juffe; Francisco Arnal; Emanuele Cozzi; D J White; Rudolf O Duthaler; Willy Kinzy; R Oehrlein; Andreas G Katopodis
Neutralization of anti-alphaGalactosyl antibodies without immunosuppression prevents hyperacute rejection but not acute vascular rejection of pig organs transplanted into baboons.
Transplantation proceedings 2000;32(5):888-9.
2000: Emanuele Cozzi; Farzana Bhatti; Michael Schmoeckel; Gilberto Chavez; Kenneth G C Smith; A Zaidi; John R Bradley; Sathia Thiru; Martin Goddard; Conrad Vial; Daniel J Ostlie; John Wallwork; David J G White; Peter J Friend
Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts.
Transplantation 2000;70(1):15-21.
2000: B Soin; Daniel J Ostlie; Emanuele Cozzi; Kenneth G C Smith; John R Bradley; Conrad Vial; S Masroor; Richard Lancaster; David J G White; Peter J Friend
Growth of porcine kidneys in their native and xenograft environment.
Xenotransplantation 2000;7(2):96-100.
2000: Emanuele Cozzi; S Masroor; B Soin; Conrad Vial; David J G White
Progress in xenotransplantation.
Clinical nephrology 2000;53(4):suppl 13-8.
2000: Conrad Vial; D J Ostlie; Farzana Bhatti; Emanuele Cozzi; Martin Goddard; Gilberto Chavez; John Wallwork; David J G White; JohnJ Dunning
Life supporting function for over one month of a transgenic porcine heart in a baboon.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2000;19(2):224-9.
1999: Michael Schmoeckel; Farzana Bhatti; A Zaidi; Emanuele Cozzi; Gilberto Chavez; John Wallwork; David J G White; Peter J Friend
Splenectomy improves survival of HDAF transgenic pig kidneys in primates.
Transplantation proceedings 1999;31(1-2):961.
1999: Farzana Bhatti; Michael Schmoeckel; A Zaidi; Emanuele Cozzi; Gilberto Chavez; Martin Goddard; JohnJ Dunning; John Wallwork; David J G White
Three-month survival of HDAFF transgenic pig hearts transplanted into primates.
Transplantation proceedings 1999;31(1-2):958.
1999: H Ishida; Andrew C Richards; Emanuele Cozzi; David J G White
Expression of human decay accelerating factor on cultured bone marrow cells from transgenic pigs.
Transplantation proceedings 1999;31(1-2):707-10.
1999: Michael Schmoeckel; Emanuele Cozzi; Gilberto Chavez; JohnJ Dunning; John Wallwork; David J G White
[Xenotransplantation of hDAF-transgenic swine hearts].
Zentralblatt für Chirurgie 1999;124(7):604-8.
1998: PD Waterworth; JohnJ Dunning; MJ Tolan; Emanuele Cozzi; Gillian Langford; Gilberto Chavez; D White; John Wallwork
Life-supporting pig-to-baboon heart xenotransplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1998;17(12):1201-7.
1998: Farzana Bhatti; A Zaidi; Michael Schmoeckel; Emanuele Cozzi; Gilberto Chavez; John Wallwork; David J G White; Peter J Friend
Survival of life-supporting HDAF transgenic kidneys in primates is enhanced by splenectomy.
Transplantation proceedings 1998;30(5):2467.
1998: A Zaidi; Farzana Bhatti; Michael Schmoeckel; Emanuele Cozzi; Gilberto Chavez; John Wallwork; D White; Peter J Friend
Kidneys from HDAF transgenic pigs are physiologically compatible with primates.
Transplantation proceedings 1998;30(5):2465-6.
1998: A Zaidi; Michael Schmoeckel; Farzana Bhatti; PD Waterworth; MJ Tolan; Emanuele Cozzi; Gilberto Chavez; Gillian Langford; Sathia Thiru; John Wallwork; D White; Peter J Friend
Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors.
Transplantation 1998;65(12):1584-90.
1998: Michael Schmoeckel; Farzana Bhatti; A Zaidi; Emanuele Cozzi; PD Waterworth; MJ Tolan; Gilda Pino-Chavez; Martin Goddard; R G Warner; Gillian Langford; JohnJ Dunning; John Wallwork; David J G White
Orthotopic heart transplantation in a transgenic pig-to-primate model.
Transplantation 1998;65(12):1570-7.
1997: Emanuele Cozzi; AW Tucker; Gillian Langford; Gilda Pino-Chavez; L Wright; M J O'Connell; V J Young; Richard Lancaster; M McLaughlin; K Hunt; M C Bordin; David J G White
Characterization of pigs transgenic for human decay-accelerating factor.
Transplantation 1997;64(10):1383-92.
1997: Michael Schmoeckel; Farzana Bhatti; A Zaidi; Emanuele Cozzi; Gilda Pino-Chavez; JohnJ Dunning; John Wallwork; David J G White
Xenotransplantation of pig organs transgenic for human DAF: an update.
Transplantation proceedings 1997;29(7):3157-8.
1997: TE Mandel; Maria Koulmanda; Emanuele Cozzi; PD Waterworth; MJ Tolan; Gillian Langford; David J G White
Transplantation of normal and DAF-transgenic fetal pig pancreas into cynomolgus monkeys.
Transplantation proceedings 1997;29(1-2 /01):940.
1997: PD Waterworth; Emanuele Cozzi; MJ Tolan; Gillian Langford; P Braidley; Gilberto Chavez; JohnJ Dunning; John Wallwork; D White
Pig-to-primate cardiac xenotransplantation and cyclophosphamide therapy.
Transplantation proceedings 1997;29(1-2):899-900.
1996: Emanuele Cozzi; David J G White
Xenotransplantation.
Current opinion in nephrology and hypertension 1996;5(6):514-8.
1996: Gillian Langford; Emanuele Cozzi; N Yannoutsos; R Lancaster; K Elsome; P Chen; David J G White
Production of pigs transgenic for human regulators of complement activation using YAC technology.
Transplantation proceedings 1996;28(2):862-3.
1996: Emanuele Cozzi; Gillian Langford; L Wright; G Pino-Chávez; A Levy; M Chatterjee; N Yannoutsos; N Miller; R Lancaster; David J G White
Longitudinal analysis of the expression of human decay accelerating factor on peripheral blood mononuclear cells and in the plasma of transgenic pigs.
Transplantation proceedings 1996;28(2):860-1.
1996: M Chatterjee; P G Watson; Emanuele Cozzi; Gilberto Chavez; David J G White
Success in guinea pig to rat orthotopic corneal xenotransplantation with cyclosporin A.
Transplantation proceedings 1996;28(2):731.
1996: Gilda Pino-Chavez; N Cary; V Young; Emanuele Cozzi; J Horsley; Gillian Langford; David J G White
The effect of h-DAF expression on endothelial cell activation of porcine xenografts.
Transplantation proceedings 1996;28(2):590-1.
1995: R Chávez-Cartaya; Emanuele Cozzi; G Pino-DeSola; Neville V Jamieson; David J G White
Regulation of complement activation in rat liver ischemia and reperfusion: expression of endothelial CD59 (RIP).
Transplantation proceedings 1995;27(5):2852-4.
1995: A M Rosengard; N Cary; J Horsley; C Belcher; Gillian Langford; Emanuele Cozzi; John Wallwork; David J G White
Endothelial expression of human decay accelerating factor in transgenic pig tissue: a potential approach for human complement inactivation in discordant xenografts.
Transplantation proceedings 1995;27(1):326-7.
1995: N Yannoutsos; Gillian Langford; Emanuele Cozzi; R Lancaster; K Elsome; P Chen; David J G White
Production of pigs transgenic for human regulators of complement activation.
Transplantation proceedings 1995;27(1):324-5.
1995: C A Carrington; Andrew C Richards; Emanuele Cozzi; Gillian Langford; N Yannoutsos; David J G White
Expression of human DAF and MCP on pig endothelial cells protects from human complement.
Transplantation proceedings 1995;27(1):321-3.
1995: Emanuele Cozzi; Gillian Langford; L Wright; A Tucker; N Yannoutsos; A Richards; A Rosengard; K Elsome; R Lancaster; David J G White
Comparative analysis of human DAF expression in the tissues of transgenic pigs and man.
Transplantation proceedings 1995;27(1):319-20.
1995: David J G White; Emanuele Cozzi; Gillian Langford; T Oglesby; M W Wang; L Wright; John Wallwork
Genetic engineering of the donor species to control hyperacute xenograft rejection.
Advances in nephrology from the Necker Hospital 1995;24():331-40.
1995: David J G White; Emanuele Cozzi; Gillian Langford; T Oglesby; M W Wang; L Wright; John Wallwork
The control of hyperacute rejection by genetic engineering of the donor species.
Eye (London, England) 1995;9 ( Pt 2)():185-9.
1994: Emanuele Cozzi; Gillian Langford; A Richards; K Elsome; R Lancaster; P Chen; N Yannoutsos; David J G White
Expression of human decay accelerating factor in transgenic pigs.
Transplantation proceedings 1994;26(3):1402-3.
1994: Gillian Langford; N Yannoutsos; Emanuele Cozzi; R Lancaster; K Elsome; P Chen; A Richards; David J G White
Production of pigs transgenic for human decay accelerating factor.
Transplantation proceedings 1994;26(3):1400-1.