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Gerald Crabtree

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
23
Graef, ISabella
14
Schreiber, Stuart
14
Winslow, Monte
12
Neilson, Joel
11
Stankunas, Kryn
11
Chen, Lei
10
Northrop, JP
8
Timmerman, Luika
8
Bayle, Henri
6
Biggar, SR
6
Chang, Ching-Pin
6
Francke, Uta
6
Wandless, Thomas
6
Kuo, Ann
6
Gestwicki, Jason

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Publications

TOP 3
Yoo Andrew S; Staahl Brett T; Chen Lei; Crabtree Gerald R
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development.
Yoo Andrew S; Crabtree Gerald R
ATP-dependent chromatin remodeling in neural development.
Ho Lena; Ronan Jehnna L; Wu Jiang; Staahl Brett T; Chen Lei; Kuo Ann; Lessard Julie; Nesvizhskii Alexey I; Ranish Jeff; Crabtree Gerald R
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.

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All Publications

2009: Yoo Andrew S; Staahl Brett T; Chen Lei; Crabtree Gerald R
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development.
Nature 2009;460(7255):642-6.
2009: Yoo Andrew S; Crabtree Gerald R
ATP-dependent chromatin remodeling in neural development.
Current opinion in neurobiology 2009;19(2):120-6.
2009: Ho Lena; Ronan Jehnna L; Wu Jiang; Staahl Brett T; Chen Lei; Kuo Ann; Lessard Julie; Nesvizhskii Alexey I; Ranish Jeff; Crabtree Gerald R
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5181-6.
2009: Ho Lena; Jothi Raja; Ronan Jehnna L; Cui Kairong; Zhao Keji; Crabtree Gerald R
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5187-91.
2009: Kao Shih-Chu; Wu Hai; Xie Jianming; Chang Ching-Pin; Ranish Jeffrey A; Graef Isabella A; Crabtree Gerald R
Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation.
Science (New York, N.Y.) 2009;323(5914):651-4.
2009: Wu Jiang I; Lessard Julie; Crabtree Gerald R
Understanding the words of chromatin regulation.
Cell 2009;136(2):200-6.
2008: Ho Lena; Crabtree Gerald R
An EZ mark to miss.
Cell stem cell 2008;3(6):577-8.
2008: Gallo Elena M; Ho Lena; Winslow Monte M; Staton Tracy L; Crabtree Gerald R
Selective role of calcineurin in haematopoiesis and lymphopoiesis.
EMBO reports 2008;9(11):1141-8.
2008: Li Daniel Hsieh-Hsin; Winslow Monte M; Cao Thai M; Chen Albert H; Davis Corrine R; Mellins Elizabeth D; Utz Paul J; Crabtree Gerald R; Parnes Jane R
Modulation of peripheral B cell tolerance by CD72 in a murine model.
Arthritis and rheumatism 2008;58(10):3192-204.
2008: Radermacher Amy N; Crabtree Gerald R
Monster protein controls calcium entry and fights infection.
Immunity 2008;28(1):13-4.
2008: Crabtree Gerald R; Graef Isabella A
Bursting into the nucleus.
Science signaling 2008;1(51):pe54.
2007: Gallo Elena M; Winslow Monte M; Canté-Barrett Kirsten; Radermacher Amy N; Ho Lena; McGinnis Lisa; Iritani Brian; Neilson Joel R; Crabtree Gerald R
Calcineurin sets the bandwidth for discrimination of signals during thymocyte development.
Nature 2007;450(7170):731-5.
2007: Wu Jiang I; Lessard Julie; Olave Ivan A; Qiu Zilong; Ghosh Anirvan; Graef Isabella A; Crabtree Gerald R
Regulation of dendritic development by neuron-specific chromatin remodeling complexes.
Neuron 2007;56(1):94-108.
2007: Wu Hai; Kao Shih-chu; Barrientos Tomasa; Baldwin Scott H; Olson Eric N; Crabtree Gerald R; Zhou Bin; Chang Ching-Pin
Down syndrome critical region-1 is a transcriptional target of nuclear factor of activated T cells-c1 within the endocardium during heart development.
The Journal of biological chemistry 2007;282(42):30673-9.
2007: Lessard Julie; Wu Jiang I; Ranish Jeffrey A; Wan Mimi; Winslow Monte M; Staahl Brett T; Wu Hai; Aebersold Ruedi; Graef Isabella A; Crabtree Gerald R
An essential switch in subunit composition of a chromatin remodeling complex during neural development.
Neuron 2007;55(2):201-15.
2007: Stankunas Kryn; Crabtree Gerald R
Exploiting protein destruction for constructive use.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(28):11511-2.
2007: Canté-Barrett Kirsten; Winslow Monte M; Crabtree Gerald R
Selective role of NFATc3 in positive selection of thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):103-10.
2007: Stankunas Kryn; Bayle J Henri; Havranek James J; Wandless Thomas J; Baker David; Crabtree Gerald R; Gestwicki Jason E
Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands.
Chembiochem : a European journal of chemical biology 2007;8(10):1162-9.
2007: Wu Jiang I; Crabtree Gerald R;
Cell signaling. Nuclear actin as choreographer of cell morphology and transcription.
Science (New York, N.Y.) 2007;316(5832):1710-1.
2007: Wu Hai; Peisley Alys; Graef Isabella A; Crabtree Gerald R
NFAT signaling and the invention of vertebrates.
Trends in cell biology 2007;17(6):251-60.
2007: Sellmyer Mark A; Stankunas Kryn; Briesewitz Roger; Crabtree Gerald R; Wandless Thomas J
Engineering small molecule specificity in nearly identical cellular environments.
Bioorganic & medicinal chemistry letters 2007;17(10):2703-5.
2007: Pan Minggui; Winslow Monte M; Chen Lei; Kuo Ann; Felsher Dean; Crabtree Gerald R
Enhanced NFATc1 nuclear occupancy causes T cell activation independent of CD28 costimulation.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4315-21.
2007: Liu Karen J; Arron Joseph R; Stankunas Kryn; Crabtree Gerald R; Longaker Michael T
Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice.
Nature 2007;446(7131):79-82.
2006: Davé Vrushank; Childs Tawanna; Xu Yan; Ikegami Machiko; Besnard Valérie; Maeda Yutaka; Wert Susan E; Neilson Joel R; Crabtree Gerald R; Whitsett Jeffrey A
Calcineurin/Nfat signaling is required for perinatal lung maturation and function.
The Journal of clinical investigation 2006;116(10):2597-609.
2006: Yang Teddy T C; Suk Hee Yun; Yang Xiaoyong; Olabisi Opeyemi; Yu Raymond Y L; Durand Jorge; Jelicks Linda A; Kim Ja-Young; Scherer Philipp E; Wang Yuhua; Feng Yun; Rossetti Luciano; Graef Isabella A; Crabtree Gerald R; Chow Chi-Wing
Role of transcription factor NFAT in glucose and insulin homeostasis.
Molecular and cellular biology 2006;26(20):7372-87.
2006: Heit Jeremy J; Apelqvist Asa A; Gu Xueying; Winslow Monte M; Neilson Joel R; Crabtree Gerald R; Kim Seung K
Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function.
Nature 2006;443(7109):345-9.
2006: Winslow Monte M; Pan Minggui; Starbuck Michael; Gallo Elena M; Deng Lei; Karsenty Gerard; Crabtree Gerald R
Calcineurin/NFAT signaling in osteoblasts regulates bone mass.
Developmental cell 2006;10(6):771-82.
2006: Arron Joseph R; Winslow Monte M; Polleri Alberto; Chang Ching-Pin; Wu Hai; Gao Xin; Neilson Joel R; Chen Lei; Heit Jeremy J; Kim Seung K; Yamasaki Nobuyuki; Miyakawa Tsuyoshi; Francke Uta; Graef Isabella A; Crabtree Gerald R
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.
Nature 2006;441(7093):595-600.
2006: Winslow Monte M; Gallo Elena M; Neilson Joel R; Crabtree Gerald R
The calcineurin phosphatase complex modulates immunogenic B cell responses.
Immunity 2006;24(2):141-52.
2006: Canté-Barrett Kirsten; Gallo Elena M; Winslow Monte M; Crabtree Gerald R
Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of bim [corrected]
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2299-306.
2006: Bayle J Henri; Grimley Joshua S; Stankunas Kryn; Gestwicki Jason E; Wandless Thomas J; Crabtree Gerald R
Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity.
Chemistry & biology 2006;13(1):99-107.
2006: Gallo Elena M; Canté-Barrett Kirsten; Crabtree Gerald R
Lymphocyte calcium signaling from membrane to nucleus.
Nature immunology 2006;7(1):25-32.
2005: Bose M; Gestwicki J E; Devasthali V; Crabtree G R; Graef I A
'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation.
Biochemical Society transactions 2005;33(Pt 4):543-7.
2005: Mammucari Cristina; Tommasi di Vignano Alice; Sharov Andrey A; Neilson Joel; Havrda Matthew C; Roop Dennis R; Botchkarev Vladimir A; Crabtree Gerald R; Dotto G Paolo
Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.
Developmental cell 2005;8(5):665-76.
2005: Yang Teddy T C; Xiong Qiufang; Graef Isabella A; Crabtree Gerald R; Chow Chi-Wing
Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complex.
Molecular and cellular biology 2005;25(3):907-20.
2005: Winslow Monte M; Crabtree Gerald R
Immunology. Decoding calcium signaling.
Science (New York, N.Y.) 2005;307(5706):56-7.
2004: Gestwicki Jason E; Crabtree Gerald R; Graef Isabella A
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.
Science (New York, N.Y.) 2004;306(5697):865-9.
2004: Chang Ching-Pin; Neilson Joel R; Bayle J Henri; Gestwicki Jason E; Kuo Ann; Stankunas Kryn; Graef Isabella A; Crabtree Gerald R
A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis.
Cell 2004;118(5):649-63.
2004: Rose Robert B; Pullen Kristi E; Bayle J Henri; Crabtree Gerald R; Alber Tom
Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2.
Biochemistry 2004;43(23):7345-55.
2004: Parsons Stephanie A; Millay Douglas P; Wilkins Benjamin J; Bueno Orlando F; Tsika Gretchen L; Neilson Joel R; Liberatore Christine M; Yutzey Katherine E; Crabtree Gerald R; Tsika Richard W; Molkentin Jeffery D
Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy.
The Journal of biological chemistry 2004;279(25):26192-200.
2004: Chang Ching-Pin; McDill Bradley W; Neilson Joel R; Joist Heidi E; Epstein Jonathan A; Crabtree Gerald R; Chen Feng
Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery.
The Journal of clinical investigation 2004;113(7):1051-8.
2004: Neilson Joel R; Winslow Monte M; Hur Eun Mi; Crabtree Gerald R
Calcineurin B1 is essential for positive but not negative selection during thymocyte development.
Immunity 2004;20(3):255-66.
2004: Brand Marjorie; Ranish Jeffrey A; Kummer Nicolas T; Hamilton Joan; Igarashi Kazuhiko; Francastel Claire; Chi Tian H; Crabtree Gerald R; Aebersold Ruedi; Groudine Mark
Dynamic changes in transcription factor complexes during erythroid differentiation revealed by quantitative proteomics.
Nature structural & molecular biology 2004;11(1):73-80.
2003: Stankunas Kryn; Bayle J Henri; Gestwicki Jason E; Lin Yun-Ming; Wandless Thomas J; Crabtree Gerald R
Conditional protein alleles using knockin mice and a chemical inducer of dimerization.
Molecular cell 2003;12(6):1615-24.
2003: Winslow Monte M; Neilson Joel R; Crabtree Gerald R
Calcium signalling in lymphocytes.
Current opinion in immunology 2003;15(3):299-307.
2003: Graef Isabella A; Wang Fan; Charron Frederic; Chen Lei; Neilson Joel; Tessier-Lavigne Marc; Crabtree Gerald R
Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.
Cell 2003;113(5):657-70.
2003: Chang Ching-Pin; Chen Lei; Crabtree Gerald R
Sonographic staging of the developmental status of mouse embryos in utero.
Genesis (New York, N.Y. : 2000) 2003;36(1):7-11.
2003: Rando Oliver J; Chi Tian H; Crabtree Gerald R
Second messenger control of chromatin remodeling.
Nature structural biology 2003;10(2):81-3.
2002: Sheridan Colleen M; Heist E Kevin; Beals Chan R; Crabtree Gerald R; Gardner Phyllis
Protein kinase A negatively modulates the nuclear accumulation of NF-ATc1 by priming for subsequent phosphorylation by glycogen synthase kinase-3.
The Journal of biological chemistry 2002;277(50):48664-76.
2002: Olave Ivan; Wang Weidong; Xue Yutong; Kuo Ann; Crabtree Gerald R
Identification of a polymorphic, neuron-specific chromatin remodeling complex.
Genes & development 2002;16(19):2509-17.
2002: Diehn Maximilian; Alizadeh Ash A; Rando Oliver J; Liu Chih Long; Stankunas Kryn; Botstein David; Crabtree Gerald R; Brown Patrick O
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11796-801.
2002: Bayle J Henri; Randazzo Filippo; Johnen Georg; Kaufman Seymour; Nagy Andras; Rossant Janet; Crabtree Gerald R
Hyperphenylalaninemia and impaired glucose tolerance in mice lacking the bifunctional DCoH gene.
The Journal of biological chemistry 2002;277(32):28884-91.
2002: Chi Tian H; Wan Mimi; Zhao Keji; Taniuchi Ichiro; Chen Lei; Littman Dan R; Crabtree Gerald R
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.
Nature 2002;418(6894):195-9.
2002: Crabtree Gerald R; Olson Eric N
NFAT signaling: choreographing the social lives of cells.
Cell 2002;109 Suppl():S67-79.
2002: Rando Oliver J; Zhao Keji; Janmey Paul; Crabtree Gerald R
Phosphatidylinositol-dependent actin filament binding by the SWI/SNF-like BAF chromatin remodeling complex.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(5):2824-9.
2002: Olave Ivan A; Reck-Peterson Samara L; Crabtree Gerald R
Nuclear actin and actin-related proteins in chromatin remodeling.
Annual review of biochemistry 2002;71():755-81.
2001: Graef I A; Chen F; Crabtree G R
NFAT signaling in vertebrate development.
Current opinion in genetics & development 2001;11(5):505-12.
2001: Graef I A; Chen F; Chen L; Kuo A; Crabtree G R
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.
Cell 2001;105(7):863-75.
2001: Biggar S R; Crabtree G R
Cell signaling can direct either binary or graded transcriptional responses.
The EMBO journal 2001;20(12):3167-76.
2001: Neilson J; Stankunas K; Crabtree G R
Monitoring the duration of antigen-receptor occupancy by calcineurin/glycogen-synthase-kinase-3 control of NF-AT nuclear shuttling.
Current opinion in immunology 2001;13(3):346-50.
2001: Graef I A; Gastier J M; Francke U; Crabtree G R
Evolutionary relationships among Rel domains indicate functional diversification by recombination.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(10):5740-5.
2001: Behrens A; Sabapathy K; Graef I; Cleary M; Crabtree G R; Wagner E F
Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT).
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1769-74.
2001: Crabtree G R
Calcium, calcineurin, and the control of transcription.
The Journal of biological chemistry 2001;276(4):2313-6.
2001: Vogel K W; Briesewitz R; Wandless T J; Crabtree G R
Calcineurin inhibitors and the generalization of the presenting protein strategy.
Advances in protein chemistry 2001;56():253-91.
2000: Rose R B; Bayle J H; Endrizzi J A; Cronk J D; Crabtree G R; Alber T
Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha.
Nature structural biology 2000;7(9):744-8.
2000: Wülfing C; Bauch A; Crabtree G R; Davis M M
The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10150-5.
2000: Biggar S R; Crabtree G R
Chemically regulated transcription factors reveal the persistence of repressor-resistant transcription after disrupting activator function.
The Journal of biological chemistry 2000;275(33):25381-90.
2000: Chi T H; Crabtree G R
Perspectives: signal transduction. Inositol phosphates in the nucleus.
Science (New York, N.Y.) 2000;287(5460):1937-9.
2000: Rando O J; Zhao K; Crabtree G R
Searching for a function for nuclear actin.
Trends in cell biology 2000;10(3):92-7.
2000: Bauch A; Alt F W; Crabtree G R; Snapper S B
The cytoskeleton in lymphocyte signaling.
Advances in immunology 2000;75():89-114.
1999: Graef I A; Mermelstein P G; Stankunas K; Neilson J R; Deisseroth K; Tsien R W; Crabtree G R
L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons.
Nature 1999;401(6754):703-8.
1999: Biggar S R; Crabtree G R
Continuous and widespread roles for the Swi-Snf complex in transcription.
The EMBO journal 1999;18(8):2254-64.
1999: Crabtree G R
Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.
Cell 1999;96(5):611-4.
1999: Briesewitz R; Ray G T; Wandless T J; Crabtree G R
Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(5):1953-8.
1999: Penninger J M; Crabtree G R
The actin cytoskeleton and lymphocyte activation.
Cell 1999;96(1):9-12.
1999: Stankunas K; Graef I A; Neilson J R; Park S H; Crabtree G R
Signaling through calcium, calcineurin, and NF-AT in lymphocyte activation and development.
Cold Spring Harbor symposia on quantitative biology 1999;64():505-16.
1998: Zhao K; Wang W; Rando O J; Xue Y; Swiderek K; Kuo A; Crabtree G R
Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling.
Cell 1998;95(5):625-36.
1998: Holsinger L J; Graef I A; Swat W; Chi T; Bautista D M; Davidson L; Lewis R S; Alt F W; Crabtree G R
Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction.
Current biology : CB 1998;8(10):563-72.
1998: de la Pompa J L; Timmerman L A; Takimoto H; Yoshida H; Elia A J; Samper E; Potter J; Wakeham A; Marengere L; Langille B L; Crabtree G R; Mak T W
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum.
Nature 1998;392(6672):182-6.
1998: Yoshida H; Nishina H; Takimoto H; Marengère L E; Wakeham A C; Bouchard D; Kong Y Y; Ohteki T; Shahinian A; Bachmann M; Ohashi P S; Penninger J M; Crabtree G R; Mak T W
The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production.
Immunity 1998;8(1):115-24.
1998: Wang W; Chi T; Xue Y; Zhou S; Kuo A; Crabtree G R
Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(2):492-8.
1998: Klemm J D; Schreiber S L; Crabtree G R
Dimerization as a regulatory mechanism in signal transduction.
Annual review of immunology 1998;16():569-92.
1997: Borchardt A; Liberles S D; Biggar S R; Crabtree G R; Schreiber S L
Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale.
Chemistry & biology 1997;4(12):961-8.
1997: Bayle J H; Crabtree G R
Protein acetylation: more than chromatin modification to regulate transcription.
Chemistry & biology 1997;4(12):885-8.
1997: Fiorentino D F; Crabtree G R
Characterization of Saccharomyces cerevisiae dna2 mutants suggests a role for the helicase late in S phase.
Molecular biology of the cell 1997;8(12):2519-37.
1997: Graef I A; Holsinger L J; Diver S; Schreiber S L; Crabtree G R
Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70.
The EMBO journal 1997;16(18):5618-28.
1997: Timmerman L A; Healy J I; Ho S N; Chen L; Goodnow C C; Crabtree G R
Redundant expression but selective utilization of nuclear factor of activated T cells family members.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2735-40.
1997: Klemm J D; Beals C R; Crabtree G R
Rapid targeting of nuclear proteins to the cytoplasm.
Current biology : CB 1997;7(9):638-44.
1997: Graef I A; Crabtree G R
The transcriptional paradox: octamer factors and B and T cells.
Science (New York, N.Y.) 1997;277(5323):193-4.
1997: Healy J I; Dolmetsch R E; Timmerman L A; Cyster J G; Thomas M L; Crabtree G R; Lewis R S; Goodnow C C
Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.
Immunity 1997;6(4):419-28.
1997: Beals C R; Clipstone N A; Ho S N; Crabtree G R
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.
Genes & development 1997;11(7):824-34.
1997: Beals C R; Sheridan C M; Turck C W; Gardner P; Crabtree G R
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3.
Science (New York, N.Y.) 1997;275(5308):1930-4.
1997: Wolfe S A; Zhou P; Dötsch V; Chen L; You A; Ho S N; Crabtree G R; Wagner G; Verdine G L
Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc.
Nature 1997;385(6612):172-6.
1996: Freiberg R A; Spencer D M; Choate K A; Peng P D; Schreiber S L; Crabtree G R; Khavari P A
Specific triggering of the Fas signal transduction pathway in normal human keratinocytes.
The Journal of biological chemistry 1996;271(49):31666-9.
1996: Crabtree G R; Schreiber S L
Three-part inventions: intracellular signaling and induced proximity.
Trends in biochemical sciences 1996;21(11):418-22.
1996: Wang W; Côté J; Xue Y; Zhou S; Khavari P A; Biggar S R; Muchardt C; Kalpana G V; Goff S P; Yaniv M; Workman J L; Crabtree G R
Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.
The EMBO journal 1996;15(19):5370-82.
1996: Timmerman L A; Clipstone N A; Ho S N; Northrop J P; Crabtree G R
Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression.
Nature 1996;383(6603):837-40.
1996: Belshaw P J; Spencer D M; Crabtree G R; Schreiber S L
Controlling programmed cell death with a cyclophilin-cyclosporin-based chemical inducer of dimerization.
Chemistry & biology 1996;3(9):731-8.
1996: Ho S; Clipstone N; Timmermann L; Northrop J; Graef I; Fiorentino D; Nourse J; Crabtree G R
The mechanism of action of cyclosporin A and FK506.
Clinical immunology and immunopathology 1996;80(3 Pt 2):S40-5.
1996: Wang W; Xue Y; Zhou S; Kuo A; Cairns B R; Crabtree G R
Diversity and specialization of mammalian SWI/SNF complexes.
Genes & development 1996;10(17):2117-30.
1996: Ho S N; Biggar S R; Spencer D M; Schreiber S L; Crabtree G R
Dimeric ligands define a role for transcriptional activation domains in reinitiation.
Nature 1996;382(6594):822-6.
1996: Spencer D M; Belshaw P J; Chen L; Ho S N; Randazzo F; Crabtree G R; Schreiber S L
Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization.
Current biology : CB 1996;6(7):839-47.
1996: Belshaw P J; Ho S N; Crabtree G R; Schreiber S L
Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4604-7.
1995: Fanger C M; Hoth M; Crabtree G R; Lewis R S
Characterization of T cell mutants with defects in capacitative calcium entry: genetic evidence for the physiological roles of CRAC channels.
The Journal of cell biology 1995;131(3):655-67.
1995: Holsinger L J; Spencer D M; Austin D J; Schreiber S L; Crabtree G R
Signal transduction in T lymphocytes using a conditional allele of Sos.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9810-4.
1995: Spencer D M; Graef I; Austin D J; Schreiber S L; Crabtree G R
A general strategy for producing conditional alleles of Src-like tyrosine kinases.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(21):9805-9.
1995: Ho S N; Thomas D J; Timmerman L A; Li X; Francke U; Crabtree G R
NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity.
The Journal of biological chemistry 1995;270(34):19898-907.
1995: Serafini A T; Lewis R S; Clipstone N A; Bram R J; Fanger C; Fiering S; Herzenberg L A; Crabtree G R
Isolation of mutant T lymphocytes with defects in capacitative calcium entry.
Immunity 1995;3(2):239-50.
1995: Schreiber S L; Crabtree G R
Immunophilins, ligands, and the control of signal transduction.
Harvey lectures 1995;91():99-114.
1995: Li X; Ho S N; Luna J; Giacalone J; Thomas D J; Timmerman L A; Crabtree G R; Francke U
Cloning and chromosomal localization of the human and murine genes for the T-cell transcription factors NFATc and NFATp.
Cytogenetics and cell genetics 1995;68(3-4):185-91.
1994: Nourse J; Firpo E; Flanagan W M; Coats S; Polyak K; Lee M H; Massague J; Crabtree G R; Roberts J M
Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin.
Nature 1994;372(6506):570-3.
1994: Kalpana G V; Marmon S; Wang W; Crabtree G R; Goff S P
Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5.
Science (New York, N.Y.) 1994;266(5193):2002-6.
1994: Pruschy M N; Spencer D M; Kapoor T M; Miyake H; Crabtree G R; Schreiber S L
Mechanistic studies of a signaling pathway activated by the organic dimerizer FK1012.
Chemistry & biology 1994;1(3):163-72.
1994: Austin D J; Crabtree G R; Schreiber S L
Proximity versus allostery: the role of regulated protein dimerization in biology.
Chemistry & biology 1994;1(3):131-6.
1994: Dunaief J L; Strober B E; Guha S; Khavari P A; Alin K; Luban J; Begemann M; Crabtree G R; Goff S P
The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest.
Cell 1994;79(1):119-30.
1994: Clipstone N A; Fiorentino D F; Crabtree G R
Molecular analysis of the interaction of calcineurin with drug-immunophilin complexes.
The Journal of biological chemistry 1994;269(42):26431-7.
1994: Ho S N; Boyer S H; Schreiber S L; Danishefsky S J; Crabtree G R
Specific inhibition of formation of transcription complexes by a calicheamicin oligosaccharide: a paradigm for the development of transcriptional antagonists.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9203-7.
1994: Northrop J P; Ho S N; Chen L; Thomas D J; Timmerman L A; Nolan G P; Admon A; Crabtree G R
NF-AT components define a family of transcription factors targeted in T-cell activation.
Nature 1994;369(6480):497-502.
1994: Ho S; Timmerman L; Northrop J; Crabtree G R
Cloning and characterization of NF-ATc and NF-ATp: the cytoplasmic components of NF-AT.
Advances in experimental medicine and biology 1994;365():167-73.
1993: Khavari P A; Peterson C L; Tamkun J W; Mendel D B; Crabtree G R
BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription.
Nature 1993;366(6451):170-4.
1993: Flanagan W M; Crabtree G R
Rapamycin inhibits p34cdc2 expression and arrests T lymphocyte proliferation at the G1/S transition.
Annals of the New York Academy of Sciences 1993;696():31-7.
1993: Spencer D M; Wandless T J; Schreiber S L; Crabtree G R
Controlling signal transduction with synthetic ligands.
Science (New York, N.Y.) 1993;262(5136):1019-24.
1993: Clipstone N A; Crabtree G R
Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506.
Annals of the New York Academy of Sciences 1993;696():20-30.
1993: Bram R J; Hung D T; Martin P K; Schreiber S L; Crabtree G R
Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location.
Molecular and cellular biology 1993;13(8):4760-9.
1993: Hansen L P; Crabtree G R
Regulation of the HNF-1 homeodomain proteins by DCoH.
Current opinion in genetics & development 1993;3(2):246-53.
1993: Milatovich A; Mendel D B; Crabtree G R; Francke U
Genes for the dimerization cofactor of hepatocyte nuclear factor-1 alpha (DCOH) are on human and murine chromosomes 10.
Genomics 1993;16(1):292-5.
1993: Ullman K S; Northrop J P; Admon A; Crabtree G R
Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes.
Genes & development 1993;7(2):188-96.
1993: Northrop J P; Ullman K S; Crabtree G R
Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.
The Journal of biological chemistry 1993;268(4):2917-23.
1992: Kuo C J; Chung J; Fiorentino D F; Flanagan W M; Blenis J; Crabtree G R
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase.
Nature 1992;358(6381):70-3.
1992: Chung J; Kuo C J; Crabtree G R; Blenis J
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases.
Cell 1992;69(7):1227-36.
1992: Clipstone N A; Crabtree G R
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation.
Nature 1992;357(6380):695-7.
1992: Northrop J P; Crabtree G R; Mattila P S
Negative regulation of interleukin 2 transcription by the glucocorticoid receptor.
The Journal of experimental medicine 1992;175(5):1235-45.
1992: Kuo C J; Conley P B; Chen L; Sladek F M; Darnell J E; Crabtree G R
A transcriptional hierarchy involved in mammalian cell-type specification.
Nature 1992;355(6359):457-61.
1992: Flanagan W M; Crabtree G R
In vitro transcription faithfully reflecting T-cell activation requirements.
The Journal of biological chemistry 1992;267(1):399-406.
1992: Riegel J S; Corthesy B; Flanagan W M; Crabtree G R
Regulation of the interleukin-2 gene.
Chemical immunology 1992;51():266-98.
1991: Mendel D B; Khavari P A; Conley P B; Graves M K; Hansen L P; Admon A; Crabtree G R
Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein.
Science (New York, N.Y.) 1991;254(5039):1762-7.
1991: Ullman K S; Flanagan W M; Cothesy B; Kuo P; Northrop J P; Crabtree G R
Site of action of cyclosporine and FK 506 in the pathways of communication between the T-lymphocyte antigen receptor and the early activation genes.
Transplantation proceedings 1991;23(6):2845.
1991: Ullman K S; Flanagan W M; Edwards C A; Crabtree G R
Activation of early gene expression in T lymphocytes by Oct-1 and an inducible protein, OAP40.
Science (New York, N.Y.) 1991;254(5031):558-62.
1991: Kuo C J; Mendel D B; Hansen L P; Crabtree G R
Independent regulation of HNF-1 alpha and HNF-1 beta by retinoic acid in F9 teratocarcinoma cells.
The EMBO journal 1991;10(8):2231-6.
1991: Flanagan W M; Corthésy B; Bram R J; Crabtree G R
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A.
Nature 1991;352(6338):803-7.
1991: Mendel D B; Hansen L P; Graves M K; Conley P B; Crabtree G R
HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro.
Genes & development 1991;5(6):1042-56.
1991: Mendel D B; Crabtree G R
HNF-1, a member of a novel class of dimerizing homeodomain proteins.
The Journal of biological chemistry 1991;266(2):677-80.
1990: Kuo C J; Conley P B; Hsieh C L; Francke U; Crabtree G R
Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9838-42.
1990: Mattila P S; Ullman K S; Fiering S; Emmel E A; McCutcheon M; Crabtree G R; Herzenberg L A
The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes.
The EMBO journal 1990;9(13):4425-33.
1990: Fiering S; Northrop J P; Nolan G P; Mattila P S; Crabtree G R; Herzenberg L A
Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.
Genes & development 1990;4(10):1823-34.
1990: Baumhueter S; Mendel D B; Conley P B; Kuo C J; Turk C; Graves M K; Edwards C A; Courtois G; Crabtree G R
HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF.
Genes & development 1990;4(3):372-9.
1990: Ullman K S; Northrop J P; Verweij C L; Crabtree G R
Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link.
Annual review of immunology 1990;8():421-52.
1989: Emmel E A; Verweij C L; Durand D B; Higgins K M; Lacy E; Crabtree G R
Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation.
Science (New York, N.Y.) 1989;246(4937):1617-20.
1989: Crabtree G R
Contingent genetic regulatory events in T lymphocyte activation.
Science (New York, N.Y.) 1989;243(4889):355-61.
1989: Baumhueter S; Courtois G; Morgan J G; Crabtree G R
The role of HNF-1 in liver-specific gene expression.
Annals of the New York Academy of Sciences 1989;557():272-8, discussion 279.
1988: Courtois G; Baumhueter S; Crabtree G R
Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(21):7937-41.
1988: Baumhueter S; Courtois G; Crabtree G R
A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the beta fibrinogen gene promoter as HNF-1.
The EMBO journal 1988;7(8):2485-93.
1988: Shaw J P; Utz P J; Durand D B; Toole J J; Emmel E A; Crabtree G R
Identification of a putative regulator of early T cell activation genes.
Science (New York, N.Y.) 1988;241(4862):202-5.
1988: Morgan J G; Courtois G; Fourel G; Chodosh L A; Campbell L; Evans E; Crabtree G R
Sp1, a CAAT-binding factor, and the adenovirus major late promoter transcription factor interact with functional regions of the gamma-fibrinogen promoter.
Molecular and cellular biology 1988;8(6):2628-37.
1988: Durand D B; Shaw J P; Bush M R; Replogle R E; Belagaje R; Crabtree G R
Characterization of antigen receptor response elements within the interleukin-2 enhancer.
Molecular and cellular biology 1988;8(4):1715-24.
1987: Chodosh L A; Carthew R W; Morgan J G; Crabtree G R; Sharp P A
The adenovirus major late transcription factor activates the rat gamma-fibrinogen promoter.
Science (New York, N.Y.) 1987;238(4827):684-8.
1987: Courtois G; Morgan J G; Campbell L A; Fourel G; Crabtree G R
Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters.
Science (New York, N.Y.) 1987;238(4827):688-92.
1987: Durand D B; Bush M R; Morgan J G; Weiss A; Crabtree G R
A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor.
The Journal of experimental medicine 1987;165(2):395-407.

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