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Charles Craik

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TOP 3
Aaron M LeBeau; Stephanie T Murphy; Francois Pepin; Henry VanBrocklin; Sai Duriseti; Joe W Gray; Byron Hann; Charles S Craik
Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer.
Aaron M LeBeau; Minhee Lee; Stephanie T Murphy; Henry VanBrocklin; Robert S Warren; Romelyn Delos Santos; Samir M Hanash; Byron Hann; John Kurhanewicz; Charles S Craik
Imaging a functional tumorigenic biomarker in the transformed epithelium.
Gregory M Lee; James H McKerrow; Eaman Balouch; David H Goetz; Ana Lazic; Charles S Craik
Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy.

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All Publications

2013: Aaron M LeBeau; Stephanie T Murphy; Francois Pepin; Henry VanBrocklin; Sai Duriseti; Joe W Gray; Byron Hann; Charles S Craik
Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer.
Cancer research 2013;73(7):2070-81.
2013: Aaron M LeBeau; Minhee Lee; Stephanie T Murphy; Henry VanBrocklin; Robert S Warren; Romelyn Delos Santos; Samir M Hanash; Byron Hann; John Kurhanewicz; Charles S Craik
Imaging a functional tumorigenic biomarker in the transformed epithelium.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(1):93-8.
2012: Gregory M Lee; James H McKerrow; Eaman Balouch; David H Goetz; Ana Lazic; Charles S Craik
Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy.
Biochemistry 2012;51(50):10087-98.
2012: Anthony O'Donoghue; Gang Qu; Jacob B Statnekov; Min Zhou; Marc O Anderson; Alma L Burlingame; Joe L DeRisi; A Alegra Eroy-Reveles; Alexander L Greninger; Daniel R Hostetter; Jessica Ingram; Giselle M Knudsen; David A Maltby; James H McKerrow; Charles S Craik
Global identification of peptidase specificity by multiplex substrate profiling.
Nature methods 2012;9(11):1095-100.
2012: Daniel Sojka; Jana Váchová; Michael Mares; James H McKerrow; Anthony O'Donoghue; Pavla Bartosová; Conor R Caffrey; Charles S Craik; Alegra A Eroy-Reveles; Zdenek Franta; Helena Frantová; Martin Horn; Giselle M Knudsen; Petr Kopácek
Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1).
The Journal of biological chemistry 2012;287(25):21152-63.
2012: Manisha Ray; Jeffry Simko; Daniel R Hostetter; Carly R K Loeb; Charles S Craik
Inhibition of Granzyme B by PI-9 protects prostate cancer cells from apoptosis.
The Prostate 2012;72(8):846-55.
2012: Shenping Wu; Yadong Yu; Akram Alian; Agustin Avila-Sakar; David S Booth; Javier Chaparro-Riggers; Charles S Craik; Robert H Edwards; Charles H Greenberg; Sarah L Griner; Narinobu Juge; JungMin Kim; Xueming Li; Maofu Liao; Claudia M Mergel; Andrea Rossi; Pavel Strop; Robert M Stroud; Robert Tampé; Yifan Cheng
Fabs enable single particle cryoEM studies of small proteins.
Structure (London, England : 1993) 2012;20(4):582-92.
2012: Eric L Schneider; Cheng-I Wang; Mick Ward; Aida Baharuddin; Christopher J Farady; David H Goetz; Melody S Lee; Charles S Craik
A reverse binding motif that contributes to specific protease inhibition by antibodies.
Journal of molecular biology 2012;415(4):699-715.
2012: Stefanie Jäger; Joshua Kane; Dong Young Kim; Brett D Anderson; Alma Burlingame; Peter Cimermancic; Charles S Craik; Kathy Franks-Skiba; John D Gross; Reuben S Harris; Judd F Hultquist; Eunju Kwon; Rebecca S LaRue; Ming Li; Cathal Mahon; Andrej Sali; Keisuke Shindo; David Stanley; Linda Yen; Nevan J Krogan
Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.
Nature 2012;481(7381):371-5.
2012: Charles S Craik; Tina Shahian
A screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor.
Methods in molecular biology (Clifton, N.J.) 2012;928():119-31.
2012: Jessica R Ingram; Matthew P Jacobson; Laura Lambeth; Kee-Chong Lim; Salma B Rafi; Manisha Ray; Debbie Ruelas; Judy A Sakanari; Charles S Craik; A Alegra Eroy-Reveles; Ivy Hsieh; James H McKerrow
Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni.
PLoS neglected tropical diseases 2012;6(4):e1589.
2011: Jungmin Kim; Robert M Stroud; Charles S Craik
Rapid identification of recombinant Fabs that bind to membrane proteins.
Methods (San Diego, Calif.) 2011;55(4):303-9.
2011: Yanchen Zhou; Juliet Agudelo; Sean M Amberg; Yen Ting Chen; Charles S Craik; David H Goetz; Elizabeth Hansell; Kai Lu; James McKerrow; William R Roush; Graham Simmons
Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay.
Antiviral research 2011;92(2):187-94.
2011: Zdenek Franta; Helena Frantova; Martin Horn; Michael Mares; James H McKerrow; Eric Schneider; Daniel Sojka; Jindrich Srba; Pavel Talacko; Conor R Caffrey; Charles S Craik; Jan Dvorak; Petr Kopacek
IrCL1 - the haemoglobinolytic cathepsin L of the hard tick, Ixodes ricinus.
International journal for parasitology 2011;41(12):1253-62.
2011: Gregory M Lee; Tina Shahian; Aida Baharuddin; Jonathan E Gable; Charles S Craik
Enzyme inhibition by allosteric capture of an inactive conformation.
Journal of molecular biology 2011;411(5):999-1016.
2011: Charles S Craik; Michael J Page; Edwin L Madison
Proteases as therapeutics.
The Biochemical journal 2011;435(1):1-16.
2011: Christopher M Brown; Manisha Ray; Aura A Eroy-Reveles; Pascal Egea; Cheryl Tajon; Charles S Craik
Peptide length and leaving-group sterics influence potency of peptide phosphonate protease inhibitors.
Chemistry & biology 2011;18(1):48-57.
2011: Marie E Fahey; Alan D Frankel; Stefanie Jäger; Dhiraj Kumar; Cathal Mahon; Lars Pache; Kanury Rao; Alex Shapiro; Melanie J Bennett; Sumit K Chanda; Charles S Craik; Nevan J Krogan
GPS-Prot: a web-based visualization platform for integrating host-pathogen interaction data.
BMC bioinformatics 2011;12():298.
2010: Christopher J Farady; Charles S Craik
Mechanisms of macromolecular protease inhibitors.
Chembiochem : a European journal of chemical biology 2010;11(17):2341-6.
2010: David T Barkan; Daniel R Hostetter; Sami Mahrus; Ursula Pieper; James A Wells; Charles S Craik; Andrej Sali
Prediction of protease substrates using sequence and structure features.
Bioinformatics (Oxford, England) 2010;26(14):1714-22.
2010: A Allart Stoop; Ravi V Joshi; Christopher T Eggers; Charles S Craik
Analysis of an engineered plasma kallikrein inhibitor and its effect on contact activation.
Biological chemistry 2010;391(4):425-33.
2010: Yamini M Ohol; David H Goetz; Kaman Chan; Michael Shiloh; Charles S Craik; Jeffery S Cox
Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence.
Cell host & microbe 2010;7(3):210-20.
2010: Molly R Darragh; Eric L Schneider; Jianlong Lou; Paul J Phojanakong; Christopher J Farady; James D Marks; Byron Hann; Charles S Craik
Tumor detection by imaging proteolytic activity.
Cancer research 2010;70(4):1505-12.
2010: Eric Camerer; Adrian Barker; Daniel N Duong; Rajkumar Ganesan; Hiroshi Kataoka; Ivo Cornelissen; Molly R Darragh; Arif Hussain; Yao-Wu Zheng; Yoga Srinivasan; Christopher Brown; Shan-Mei Xu; Jean B Regard; Chen-Yong Lin; Charles S Craik; Daniel Kirchhofer; Shaun R Coughlin
Local protease signaling contributes to neural tube closure in the mouse embryo.
Developmental cell 2010;18(1):25-38.
2010: Byoung-Kuk Na; Young-An Bae; Young-Gun Zo; Youngchool Choe; Seon-Hee Kim; Prashant V Desai; Mitchell A Avery; Charles S Craik; Tong-Soo Kim; Philip J Rosenthal; Yoon Kong
Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4.
PLoS neglected tropical diseases 2010;4(10):e849.
2009: Cathal S Mahon; Anthony O'Donoghue; David H Goetz; Patrick G Murray; Charles S Craik; Maria G Tuohy
Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii.
Microbiology (Reading, England) 2009;155(Pt 11):3673-82.
2009: Young-wook Jun; Sassan Sheikholeslami; Daniel R Hostetter; Cheryl Tajon; Charles S Craik; A. Paul Alivisatos
Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17735-40.
2009: Iain D Kerr; Ji H Lee; Christopher J Farady; Rachael Marion; Mathias Rickert; Mohammed Sajid; Kailash C Pandey; Conor R Caffrey; Jennifer Legac; Elizabeth Hansell; James H McKerrow; Charles S Craik; Philip J Rosenthal; Linda S Brinen
Vinyl sulfones as antiparasitic agents and a structural basis for drug design.
The Journal of biological chemistry 2009;284(38):25697-703.
2009: Tina Shahian; Gregory M Lee; Ana Lazic; Leggy Arnold; Priya Velusamy; Christina M Roels; R Kiplin Guy; Charles S Craik
Inhibition of a viral enzyme by a small-molecule dimer disruptor.
Nature chemical biology 2009;5(9):640-6.
2009: Christopher J Farady; Benjamin D Sellers; Matthew P Jacobson; Charles S Craik
Improving the species cross-reactivity of an antibody using computational design.
Bioorganic & medicinal chemistry letters 2009;19(14):3744-7.
2009: James H McKerrow; Patricia S Doyle; Juan C Engel; Larissa M Podust; S A Robertson; R Ferreira; T Saxton; M Arkin; I D Kerr; Linda S Brinen; Charles S Craik
Two approaches to discovering and developing new drugs for Chagas disease.
Memórias do Instituto Oswaldo Cruz 2009;104 Suppl 1():263-9.
2009: Jennifer Noel Lilla; Ravi V Joshi; Charles S Craik; Zena Werb
Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution.
The Journal of biological chemistry 2009;284(20):13792-803.
2009: Márcia A Liz; Carolina E Fleming; Ana F Nunes; Maria R Almeida; Fernando M Mar; Youngchool Choe; Charles S Craik; James C Powers; Matthew Bogyo; Mónica Mendes Sousa
Substrate specificity of transthyretin: identification of natural substrates in the nervous system.
The Biochemical journal 2009;419(2):467-74.
2009: Gregory M Lee; Charles S Craik
Trapping moving targets with small molecules.
Science (New York, N.Y.) 2009;324(5924):213-5.
2009: Mark D Lim; Charles S Craik
Using specificity to strategically target proteases.
Bioorganic & medicinal chemistry 2009;17(3):1094-100.
2009: Jan Dvorák; Susan T Mashiyama; Mohammed Sajid; Simon Braschi; Melaine Delcroix; Eric L Schneider; Wilson H McKerrow; Mahmoud Bahgat; Elizabeth Hansell; Patricia C Babbitt; Charles S Craik; James H McKerrow; Conor R Caffrey
SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni.
PLoS neglected tropical diseases 2009;3(6):e449.
2009: Eric L Schneider; Charles S Craik
Positional scanning synthetic combinatorial libraries for substrate profiling.
Methods in molecular biology (Clifton, N.J.) 2009;539():59-78.
2009: Shoba Subramanian; Markus Hardt; Youngchool Choe; Richard K Niles; Eric B Johansen; Jennifer Legac; Jiri Gut; Iain D Kerr; Charles S Craik; Philip J Rosenthal
Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.
PloS one 2009;4(4):e5156.
2008: Theresa C O'Brien; Zachary B Mackey; Richard D Fetter; Youngchool Choe; Anthony O'Donoghue; Min Zhou; Charles S Craik; Conor R Caffrey; James H McKerrow
A parasite cysteine protease is key to host protein degradation and iron acquisition.
The Journal of biological chemistry 2008;283(43):28934-43.
2008: Digvijay A Raorane; Mark D Lim; Fanqing Frank Chen; Charles S Craik; Arun Majumdar
Quantitative and label-free technique for measuring protease activity and inhibition using a microfluidic cantilever array.
Nano letters 2008;8(9):2968-74.
2008: Christopher J Farady; Pascal F Egea; Eric L Schneider; Molly R Darragh; Charles S Craik
Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition.
Journal of molecular biology 2008;380(2):351-60.
2008: Mekdes Debela; Nathalie Beaufort; Viktor Magdolen; Norman M Schechter; Charles S Craik; Manfred Schmitt; Wolfram Bode; Peter Goettig
Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.
Biological chemistry 2008;389(6):623-32.
2008: Colin M Stack; Conor R Caffrey; Sheila M Donnelly; Amritha Seshaadri; Jonathan Lowther; Jose F. Tort; Peter R Collins; Mark W Robinson; Weibo Xu; James H McKerrow; Charles S Craik; Sebastian R Geiger; Rachel Marion; Linda S Brinen; John P Dalton
Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica.
The Journal of biological chemistry 2008;283(15):9896-908.
2008: Molly R Darragh; Ami S Bhatt; Charles S Craik
MT-SP1 proteolysis and regulation of cell-microenvironment interactions.
Frontiers in bioscience : a journal and virtual library 2008;13():528-39.
2007: Ana Lazic; David H Goetz; Anson M Nomura; Alan B Marnett; Charles S Craik
Substrate modulation of enzyme activity in the herpesvirus protease family.
Journal of molecular biology 2007;373(4):913-23.
2007: Daniel R Hostetter; Carly R K Loeb; Feixia Chu; Charles S Craik
Hip is a pro-survival substrate of granzyme B.
The Journal of biological chemistry 2007;282(38):27865-74.
2007: D H Goetz; Youngchool Choe; Elizabeth Hansell; Y T Chen; M McDowell; C B Jonsson; William R Roush; James H McKerrow; Charles S Craik
Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus.
Biochemistry 2007;46(30):8744-52.
2007: Christopher J Farady; Jeonghoon Sun; Molly R Darragh; Susan Miller; Charles S Craik
The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1).
Journal of molecular biology 2007;369(4):1041-51.
2007: Daniel Sojka; Ondrej Hajdusek; Josef Dvorák; Mohammed Sajid; Zdenek Franta; Eric L Schneider; Charles S Craik; Marie Vancová; Veronika Buresová; Matthew Bogyo; Kelly B Sexton; James H McKerrow; Conor R Caffrey; Petr Kopácek
IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus.
International journal for parasitology 2007;37(7):713-24.
2007: Ami S Bhatt; Alana Welm; Christopher J Farady; Maximiliano Vásquez; Keith Wilson; Charles S Craik
Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5771-6.
2006: Carly R K Loeb; Jennifer L Harris; Charles S Craik
Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.
The Journal of biological chemistry 2006;281(38):28326-35.
2006: Kyewhan Park; Melanie K Kuechle; Youngchool Choe; Charles S Craik; Owen T Lawrence; Richard B Presland
Expression and characterization of constitutively active human caspase-14.
Biochemical and biophysical research communications 2006;347(4):941-8.
2006: Mekdes Debela; Viktor Magdolen; Norman M Schechter; Martina Valachova; Friedrich Lottspeich; Charles S Craik; Youngchool Choe; Wolfram Bode; Peter Goettig
Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences.
The Journal of biological chemistry 2006;281(35):25678-88.
2006: Feixia Chu; Sami Mahrus; Charles S Craik; Al L Burlingame
Isotope-coded and affinity-tagged cross-linking (ICATXL): an efficient strategy to probe protein interaction surfaces.
Journal of the American Chemical Society 2006;128(32):10362-3.
2006: Leif R Lund; Kirsty A Green; Allart A Stoop; Michael Ploug; Kasper Almholt; Jennifer Noel Lilla; Boye Nielsen; Ib Jarle Christensen; Charles S Craik; Zena Werb; Keld Danø; John Rømer
Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.
The EMBO journal 2006;25(12):2686-97.
2006: Teaster T Baird; William D Wright; Charles S Craik
Conversion of trypsin to a functional threonine protease.
Protein science : a publication of the Protein Society 2006;15(6):1229-38.
2006: Youngchool Choe; Francesco Leonetti; Doron C Greenbaum; Fabien Lecaille; Matthew Bogyo; Dieter Brömme; Jonathan A Ellman; Charles S Craik
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.
The Journal of biological chemistry 2006;281(18):12824-32.
2006: Anson M Nomura; Alan B Marnett; Nobuhisa Shimba; Volker Dötsch; Charles S Craik
One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease.
Biochemistry 2006;45(11):3572-9.
2005: Anson M Nomura; Alan B Marnett; Nobuhisa Shimba; Volker Dötsch; Charles S Craik
Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
Nature structural & molecular biology 2005;12(11):1019-20.
2005: Sylvia Herter; Derek E Piper; Wade Aaron; Timothy Gabriele; Gene Cutler; Ping Cao; Ami S Bhatt; Youngchool Choe; Charles S Craik; Nigel Walker; David Meininger; Timothy Hoey; Richard J Austin
Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.
The Biochemical journal 2005;390(Pt 1):125-36.
2005: Ami S Bhatt; Hediye Erdjument-Bromage; Paul Tempst; Charles S Craik; Mark M Moasser
Adhesion signaling by a novel mitotic substrate of src kinases.
Oncogene 2005;24(34):5333-43.
2005: Sami Mahrus; Charles S Craik
Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells.
Chemistry & biology 2005;12(5):567-77.
2005: Youngchool Choe; Linda S Brinen; Mark S Price; Juan C Engel; Meinolf Lange; Corinna Grisostomi; Scott G Weston; Peter V Pallai; Hong Cheng; Larry W Hardy; David S Hartsough; Marsha McMakin; Robert F Tilton; Carmen M Baldino; Charles S Craik
Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease.
Bioorganic & medicinal chemistry 2005;13(6):2141-56.
2005: Alan B Marnett; Charles S Craik
Papa's got a brand new tag: advances in identification of proteases and their substrates.
Trends in biotechnology 2005;23(2):59-64.
2005: Masazumi Matsumura; Ami S Bhatt; Dennis Andress; Nigel Clegg; Thomas K Takayama; Charles S Craik; Peter S Nelson
Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries.
The Prostate 2005;62(1):1-13.
2004: Sami Mahrus; Walter Kisiel; Charles S Craik
Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B.
The Journal of biological chemistry 2004;279(52):54275-82.
2004: Nobuhisa Shimba; Helena Kovacs; Alan S Stern; Anson M Nomura; Ichio Shimada; Jeffrey C Hoch; Charles S Craik; Volker Dötsch
Optimization of 13C direct detection NMR methods.
Journal of biomolecular NMR 2004;30(2):175-9.
2004: Angela L Williamson; Paolo Lecchi; Benjamin E Turk; Youngchool Choe; Peter J Hotez; James H McKerrow; Lewis C Cantley; Mohammed Sajid; Charles S Craik; Alex Loukas
A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms.
The Journal of biological chemistry 2004;279(34):35950-7.
2004: Sandra Waugh Ruggles; Robert J Fletterick; Charles S Craik
Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity.
The Journal of biological chemistry 2004;279(29):30751-9.
2004: Zach Serber; Wesley Straub; Lorenzo Corsini; Anson M Nomura; Nobuhisa Shimba; Charles S Craik; Paul R. Ortiz de Montellano; Volker Dötsch
Methyl groups as probes for proteins and complexes in in-cell NMR experiments.
Journal of the American Chemical Society 2004;126(22):7119-25.
2004: Nobuhisa Shimba; Anson M Nomura; Alan B Marnett; Charles S Craik
Herpesvirus protease inhibition by dimer disruption.
Journal of virology 2004;78(12):6657-65.
2004: Alan B Marnett; Anson M Nomura; Nobuhisa Shimba; Paul R. Ortiz de Montellano; Charles S Craik
Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):6870-5.
2004: Christopher T. Eggers; Iain A Murray; Valerie A Delmar; Anthony G Day; Charles S Craik
The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase.
The Biochemical journal 2004;379(Pt 1):107-18.
2004: Byoung-Kuk Na; Bhaskar R Shenai; Puran S Sijwali; Youngchool Choe; Kailash C Pandey; Ajay Singh; Charles S Craik; Philip J Rosenthal
Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax.
The Biochemical journal 2004;378(Pt 2):529-38.
2003: Wilfred W Raymond; Sandra Waugh Ruggles; Charles S Craik; George H Caughey
Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site.
The Journal of biological chemistry 2003;278(36):34517-24.
2003: A Allart Stoop; Charles S Craik
Engineering of a macromolecular scaffold to develop specific protease inhibitors.
Nature biotechnology 2003;21(9):1063-8.
2003: Nobuhisa Shimba; Zach Serber; Richard Ledwidge; Susan Miller; Charles S Craik; Volker Dötsch
Quantitative identification of the protonation state of histidines in vitro and in vivo.
Biochemistry 2003;42(30):9227-34.
2003: Jessica K Bell; David H Goetz; Sami Mahrus; Jennifer L Harris; Robert J Fletterick; Charles S Craik
The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity.
Nature structural biology 2003;10(7):527-34.
2003: Barbara Leiting; KellyAnn D Pryor; Joseph K Wu; Frank Marsilio; Reshma A Patel; Charles S Craik; Jonathan A Ellman; Richard T Cummings; Nancy A Thornberry
Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII.
The Biochemical journal 2003;371(Pt 2):525-32.
2003: Carl E Mackewicz; Charles S Craik; Jay A Levy
The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3433-8.
2003: Nobuhisa Shimba; Alan S Stern; Charles S Craik; Jeffrey C Hoch; Volker Dötsch
Elimination of 13Calpha splitting in protein NMR spectra by deconvolution with maximum entropy reconstruction.
Journal of the American Chemical Society 2003;125(9):2382-3.
2003: Jeonghoon Sun; Jaume Pons; Charles S Craik
Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies.
Biochemistry 2003;42(4):892-900.
2003: Ami S Bhatt; Toshi Takeuchi; Bauke Ylstra; David Ginzinger; Donna Albertson; Marc Shuman; Charles S Craik
Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells.
Biological chemistry 2003;384(2):257-66.
2002: Amy M Barrios; Charles S Craik
Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence.
Bioorganic & medicinal chemistry letters 2002;12(24):3619-23.
2002: Ajay Singh; Bhaskar R Shenai; Youngchool Choe; Jiri Gut; Puran S Sijwali; Charles S Craik; Philip J Rosenthal
Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites.
The Biochemical journal 2002;368(Pt 1):273-81.
2002: Xueqing Wang; Youngchool Choe; Charles S Craik; Jonathan A Ellman
Design and synthesis of novel inhibitors of gelatinase B.
Bioorganic & medicinal chemistry letters 2002;12(16):2201-4.
2002: Martha C A Laboissière; Malin M Young; Rilva G Pinho; Stephen Todd; Robert J Fletterick; Irwin D Kuntz; Charles S Craik
Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition.
The Journal of biological chemistry 2002;277(29):26623-31.
2002: Jason P Salter; Youngchool Choe; Hugo Albrecht; Christopher Franklin; Kee-Chong Lim; Charles S Craik; James H McKerrow
Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes.
The Journal of biological chemistry 2002;277(27):24618-24.
2002: Fabien Lecaille; Youngchool Choe; Wolfgang Brandt; Zhenqiang Li; Charles S Craik; Dieter Brömme
Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity.
Biochemistry 2002;41(26):8447-54.
2002: Mary A Mathieu; Matthew Bogyo; Conor R Caffrey; Youngchool Choe; Jewok Lee; Harold Chapman; Mohammed Sajid; Charles S Craik; James H McKerrow
Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries.
Molecular and biochemical parasitology 2002;121(1):99-105.
2002: Keith K. Reiling; Nicholas F Endres; Deborah S Dauber; Charles S Craik; Robert M Stroud
Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure.
Biochemistry 2002;41(14):4582-94.
2002: Bixun Wang; Kathlynn Brown; Michiel Lodder; Charles S Craik; Sidney Hecht
Chemically mediated site-specific proteolysis. Alteration of protein-protein interaction.
Biochemistry 2002;41(8):2805-13.
2002: Dustin J Maly; Francesco Leonetti; Bradley J Backes; Deborah S Dauber; Jennifer L Harris; Charles S Craik; Jonathan A Ellman
Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.
The Journal of organic chemistry 2002;67(3):910-5.
2002: Todd R Pray; Keith K. Reiling; Berj G Demirjian; Charles S Craik
Conformational change coupling the dimerization and activation of KSHV protease.
Biochemistry 2002;41(5):1474-82.
2002: Deborah S Dauber; Rainer Ziermann; Neil Parkin; Dustin J Maly; Sami Mahrus; Jennifer L Harris; Jonathan A Ellman; Christos J Petropoulos; Charles S Craik
Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease.
Journal of virology 2002;76(3):1359-68.
2001: Jennifer L Harris; AL Niles; Keith W Burdick; M Maffitt; Bradley J Backes; Jonathan A Ellman; Irwin D Kuntz; Mary Haak-Frendscho; Charles S Craik
Definition of the extended substrate specificity determinants for beta-tryptases I and II.
The Journal of biological chemistry 2001;276(37):34941-7.
2001: M D Person; Kathlynn Brown; Sami Mahrus; Charles S Craik; Al L Burlingame
Novel inter-protein cross-link identified in the GGH-ecotin D137Y dimer.
Protein science : a publication of the Protein Society 2001;10(8):1549-62.
2001: Christopher T. Eggers; S X Wang; Robert J Fletterick; Charles S Craik
The role of ecotin dimerization in protease inhibition.
Journal of molecular biology 2001;308(5):975-91.
2001: S Selvarajan; L R Lund; T Takeuchi; Charles S Craik; Z Werb
A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation.
Nature cell biology 2001;3(3):267-75.
2001: K Nealon; William W Newcomb; Todd R Pray; Charles S Craik; Jay C Brown; Dean H Kedes
Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus.
Journal of virology 2001;75(6):2866-78.
2000: Keith K. Reiling; Todd R Pray; Charles S Craik; Robert M Stroud
Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements.
Biochemistry 2000;39(42):12796-803.
2000: S M Waugh; Jennifer L Harris; Robert J Fletterick; Charles S Craik
The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity.
Nature structural biology 2000;7(9):762-5.
2000: T Takeuchi; Jennifer L Harris; W Huang; K W Yan; Shaun R Coughlin; Charles S Craik
Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates.
The Journal of biological chemistry 2000;275(34):26333-42.
2000: Jennifer L Harris; Bradley J Backes; Francesco Leonetti; Sami Mahrus; Jonathan A Ellman; Charles S Craik
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7754-9.
2000: SA Gillmor; T Takeuchi; S Q Yang; Charles S Craik; Robert J Fletterick
Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases.
Journal of molecular biology 2000;299(4):993-1003.
2000: J E Rozzelle; Deborah S Dauber; Stephen Todd; R Kelley; Charles S Craik
Macromolecular inhibitors of HIV-1 protease. Characterization of designed heterodimers.
The Journal of biological chemistry 2000;275(10):7080-6.
2000: Gilberto R Sambrano; W Huang; TR Faruqi; Sami Mahrus; Charles S Craik; Shaun R Coughlin
Cathepsin G activates protease-activated receptor-4 in human platelets.
The Journal of biological chemistry 2000;275(10):6819-23.
2000: Stephen Todd; C Anderson; D J Jolly; Charles S Craik
HIV protease as a target for retrovirus vector-mediated gene therapy.
Biochimica et biophysica acta 2000;1477(1-2):168-88.
2000: Bradley J Backes; Jennifer L Harris; Francesco Leonetti; Charles S Craik; Jonathan A Ellman
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin.
Nature biotechnology 2000;18(2):187-93.
2000: Stephen Todd; M C Laboissière; Charles S Craik
Yeast two-hybrid assay for examining human immunodeficiency virus protease heterodimer formation with dominant-negative inhibitors and multidrug-resistant variants.
Analytical biochemistry 2000;277(2):247-53.
1999: T Takeuchi; Marc Shuman; Charles S Craik
Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11054-61.
1999: Todd R Pray; Anson M Nomura; Michael Pennington; Charles S Craik
Auto-inactivation by cleavage within the dimer interface of Kaposi's sarcoma-associated herpesvirus protease.
Journal of molecular biology 1999;289(2):197-203.
1998: Jennifer L Harris; EP Peterson; Dorothy Hudig; Nancy A Thornberry; Charles S Craik
Definition and redesign of the extended substrate specificity of granzyme B.
The Journal of biological chemistry 1998;273(42):27364-73.
1998: S Q Yang; Charles S Craik
Engineering bidentate macromolecular inhibitors for trypsin and urokinase-type plasminogen activator.
Journal of molecular biology 1998;279(4):1001-11.
1998: S Q Yang; C I Wang; SA Gillmor; Robert J Fletterick; Charles S Craik
Ecotin: a serine protease inhibitor with two distinct and interacting binding sites.
Journal of molecular biology 1998;279(4):945-57.
1998: Kathlynn Brown; Z Yu; Al L Burlingame; Charles S Craik
Determining protein-protein interactions by oxidative cross-linking of a glycine-glycine-histidine fusion protein.
Biochemistry 1998;37(13):4397-406.
1998: R B Rose; Charles S Craik; Robert M Stroud
Domain flexibility in retroviral proteases: structural implications for drug resistant mutations.
Biochemistry 1998;37(8):2607-21.
1998: J L Harris; Charles S Craik
Engineering enzyme specificity.
Current opinion in chemical biology 1998;2(1):127-32.
1998: Deborah S Dauber; F McPhee; A Unal; Charles S Craik
Optimization of a macromolecular inhibitor of HIV-1 protease.
Advances in experimental medicine and biology 1998;436():65-70.
1998: Charles S Craik; LM Babé; Deborah S Dauber; F McPhee; J Rosé; A Unal
Engineering catalytically defective forms of HIV protease to modulate its activity.
Advances in experimental medicine and biology 1998;436():31-9.
1997: John J Perona; Charles S Craik
Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold.
The Journal of biological chemistry 1997;272(48):29987-90.
1997: LM Babé; Charles S Craik
Viral proteases: evolution of diverse structural motifs to optimize function.
Cell 1997;91(4):427-30.
1997: P S Caldera; Z Yu; RM Knegtel; F McPhee; Al L Burlingame; Charles S Craik; Irwin D Kuntz; Paul R. Ortiz de Montellano
Alkylation of a catalytic aspartate group of the SIV protease by an epoxide inhibitor.
Bioorganic & medicinal chemistry 1997;5(11):2019-27.
1997: A Unal; Todd R Pray; Michael Lagunoff; Michael Pennington; Don Ganem; Charles S Craik
The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8).
Journal of virology 1997;71(9):7030-8.
1997: SA Gillmor; Charles S Craik; Robert J Fletterick
Structural determinants of specificity in the cysteine protease cruzain.
Protein science : a publication of the Protein Society 1997;6(8):1603-11.
1997: Earl Rutenber; J J De Voss; L Hoffman; Robert M Stroud; K H Lee; Juan Alvarez; F McPhee; Charles S Craik; Paul R. Ortiz de Montellano
The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease.
Bioorganic & medicinal chemistry 1997;5(7):1311-20.
1997: G R Ewoldt; Mark J Smyth; Phillip K Darcy; J L Harris; Charles S Craik; B Horowitz; SL Woodard; James C Powers; Dorothy Hudig
P-4 and RNKP-7, new granzyme-like serine proteases expressed in activated rat lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4574-83.
1997: C A Tsu; J J Perona; Robert J Fletterick; Charles S Craik
Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1.
Biochemistry 1997;36(18):5393-401.
1997: J J Perona; C A Tsu; Charles S Craik; Robert J Fletterick
Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix.
Biochemistry 1997;36(18):5381-92.
1997: LM Babé; A Unal; Charles S Craik
Obstruction of HIV-1 particle release by interferon-alpha occurs before viral protease processing and is independent of envelope glycoprotein.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997;17(5):287-93.
1997: M Kågedahl; Peter Swaan; C T Redemann; Ming-Xin Tang; Charles S Craik; Francis C Szoka; S Oie
Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity.
Pharmaceutical research 1997;14(2):176-80.
1996: F McPhee; P S Caldera; G W Bemis; A F McDonagh; Irwin D Kuntz; Charles S Craik
Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro.
The Biochemical journal 1996;320 ( Pt 2)():681-6.
1996: U Junker; S Escaich; I Plavec; J Baker; F McPhee; J R Rose; Charles S Craik; E Böhnlein
Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.
Journal of virology 1996;70(11):7765-72.
1996: F McPhee; A C Good; Irwin D Kuntz; Charles S Craik
Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11477-81.
1996: R B Rose; Charles S Craik; N L Douglas; Robert M Stroud
Three-dimensional structures of HIV-1 and SIV protease product complexes.
Biochemistry 1996;35(39):12933-44.
1996: Earl Rutenber; F McPhee; A P Kaplan; S L Gallion; J C Hogan; Charles S Craik; Robert M Stroud
A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere.
Bioorganic & medicinal chemistry 1996;4(9):1545-58.
1996: R Li; X Chen; B Gong; P M Selzer; Z Li; E Davidson; G Kurzban; R E Miller; E O Nuzum; James H McKerrow; Robert J Fletterick; S A Gillmor; Charles S Craik; Irwin D Kuntz; Fred Cohen; G L Kenyon
Structure-based design of parasitic protease inhibitors.
Bioorganic & medicinal chemistry 1996;4(9):1421-7.
1996: L S Brinen; W S Willett; Charles S Craik; Robert J Fletterick
X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
Biochemistry 1996;35(19):5999-6009.
1996: W S Willett; L S Brinen; Robert J Fletterick; Charles S Craik
Delocalizing trypsin specificity with metal activation.
Biochemistry 1996;35(19):5992-8.
1996: C A Tsu; Charles S Craik
Substrate recognition by recombinant serine collagenase 1 from Uca pugilator.
The Journal of biological chemistry 1996;271(19):11563-70.
1996: E Gudmundsdóttir; R Spilliaert; Q Yang; Charles S Craik; J B Bjarnason; A Gudmundsdóttir
Isolation and characterization of two cDNAs from Atlantic cod encoding two distinct psychrophilic elastases.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1996;113(4):795-801.
1996: C I Wang; Q Yang; Charles S Craik
Phage display of proteases and macromolecular inhibitors.
Methods in enzymology 1996;267():52-68.
1995: L M Babé; J Rosé; Charles S Craik
Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10069-73.
1995: SH Liu; M L Wong; Charles S Craik; Frances M Brodsky
Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs.
Cell 1995;83(2):257-67.
1995: David R Corey; W S Willett; G S Coombs; Charles S Craik
Trypsin specificity increased through substrate-assisted catalysis.
Biochemistry 1995;34(36):11521-7.
1995: C I Wang; Q Yang; Charles S Craik
Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin.
The Journal of biological chemistry 1995;270(20):12250-6.
1995: J R Rosé; L M Babé; Charles S Craik
Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity.
Journal of virology 1995;69(5):2751-8.
1995: M E McGrath; A E Eakin; Juan C Engel; James H McKerrow; Charles S Craik; Robert J Fletterick
The crystal structure of cruzain: a therapeutic target for Chagas' disease.
Journal of molecular biology 1995;247(2):251-9.
1995: J J Perona; Charles S Craik
Structural basis of substrate specificity in the serine proteases.
Protein science : a publication of the Protein Society 1995;4(3):337-60.
1995: D L Sloane; R Leung; J Barnett; Charles S Craik; E Sigal
Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity.
Protein engineering 1995;8(3):275-82.
1995: W S Willett; S A Gillmor; J J Perona; Robert J Fletterick; Charles S Craik
Engineered metal regulation of trypsin specificity.
Biochemistry 1995;34(7):2172-80.
1994: J R Rosé; Charles S Craik
Structure-assisted design of nonpeptide human immunodeficiency virus-1 protease inhibitors.
American journal of respiratory and critical care medicine 1994;150(6 Pt 2):S176-82.
1994: L M Babé; Charles S Craik
Constitutive production of nonenveloped human immunodeficiency virus type 1 particles by a mammalian cell line and effects of a protease inhibitor on particle maturation.
Antimicrobial agents and chemotherapy 1994;38(10):2430-9.
1994: A Guthmundsdóttir; S Oskarsson; A E Eakin; Charles S Craik; J B Bjarnason
Atlantic cod cDNA encoding a psychrophilic chymotrypsinogen.
Biochimica et biophysica acta 1994;1219(1):211-4.
1994: C A Tsu; J J Perona; V Schellenberger; Christoph W Turck; Charles S Craik
The substrate specificity of Uca pugilator collagenolytic serine protease 1 correlates with the bovine type I collagen cleavage sites.
The Journal of biological chemistry 1994;269(30):19565-72.
1994: Brian W Matthews; Charles S Craik; H Neurath
Can small cyclic peptides have the activity and specificity of proteolytic enzymes?
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4103-5.
1994: R Salto; L M Babé; J Li; J R Rosé; Z Yu; Al L Burlingame; J J De Voss; Z Sui; Paul R. Ortiz de Montellano; Charles S Craik
In vitro characterization of nonpeptide irreversible inhibitors of HIV proteases.
The Journal of biological chemistry 1994;269(14):10691-8.
1994: J J Perona; Lizbeth Hedstrom; R L Wagner; W J Rutter; Charles S Craik; Robert J Fletterick
Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser.
Biochemistry 1994;33(11):3252-9.
1994: J J De Voss; Z Sui; D L DeCamp; R Salto; L M Babé; Charles S Craik; Paul R. Ortiz de Montellano
Haloperidol-based irreversible inhibitors of the HIV-1 and HIV-2 proteases.
Journal of medicinal chemistry 1994;37(5):665-73.
1993: J J Perona; L B Evnin; Charles S Craik
A genetic selection elucidates structural determinants of arginine versus lysine specificity in trypsin.
Gene 1993;137(1):121-6.
1993: Z Sui; R Salto; J Li; Charles S Craik; Paul R. Ortiz de Montellano
Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes.
Bioorganic & medicinal chemistry 1993;1(6):415-22.
1993: R B Rose; J R Rosé; R Salto; Charles S Craik; Robert M Stroud
Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor.
Biochemistry 1993;32(46):12498-507.
1993: A Gudmundsdóttir; E Gudmundsdóttir; S Oskarsson; J B Bjarnason; A K Eakin; Charles S Craik
Isolation and characterization of cDNAs from Atlantic cod encoding two different forms of trypsinogen.
European journal of biochemistry / FEBS 1993;217(3):1091-7.
1993: J J Perona; Charles S Craik; Robert J Fletterick
Locating the catalytic water molecule in serine proteases.
Science (New York, N.Y.) 1993;261(5121):620-2.
1993: D R Corey; A K Shiau; Q Yang; B A Janowski; Charles S Craik
Trypsin display on the surface of bacteriophage.
Gene 1993;128(1):129-34.
1993: J R Rosé; R Salto; Charles S Craik
Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutions.
The Journal of biological chemistry 1993;268(16):11939-45.
1993: J J Perona; C A Tsu; M E McGrath; Charles S Craik; Robert J Fletterick
Relocating a negative charge in the binding pocket of trypsin.
Journal of molecular biology 1993;230(3):934-49.
1993: J J Perona; C A Tsu; Charles S Craik; Robert J Fletterick
Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI.
Journal of molecular biology 1993;230(3):919-33.
1993: A E Eakin; M E McGrath; James H McKerrow; Robert J Fletterick; Charles S Craik
Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi.
The Journal of biological chemistry 1993;268(9):6115-8.
1993: M E McGrath; B L Haymore; N L Summers; Charles S Craik; Robert J Fletterick
Structure of an engineered, metal-actuated switch in trypsin.
Biochemistry 1993;32(8):1914-9.
1992: L M Babé; J Rosé; Charles S Craik
Synthetic "interface" peptides alter dimeric assembly of the HIV 1 and 2 proteases.
Protein science : a publication of the Protein Society 1992;1(10):1244-53.
1992: D L DeCamp; L M Babé; R Salto; J L Lucich; M S Koo; S B Kahl; Charles S Craik
Specific inhibition of HIV-1 protease by boronated porphyrins.
Journal of medicinal chemistry 1992;35(18):3426-8.
1992: A E Eakin; Alea A Mills; Günter Harth; James H McKerrow; Charles S Craik
The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi.
The Journal of biological chemistry 1992;267(11):7411-20.
1992: M E McGrath; J R Vásquez; Charles S Craik; An-Suei Yang; Barry Honig; Robert J Fletterick
Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214.
Biochemistry 1992;31(12):3059-64.
1992: T Erpel; P Hwang; Charles S Craik; Robert J Fletterick; M E McGrath
Physical map location of the new Escherichia coli gene eco, encoding the serine protease inhibitor ecotin.
Journal of bacteriology 1992;174(5):1704.
1992: J N Higaki; Robert J Fletterick; Charles S Craik
Engineered metalloregulation in enzymes.
Trends in biochemical sciences 1992;17(3):100-4.
1991: D L Sloane; R Leung; Charles S Craik; E Sigal
A primary determinant for lipoxygenase positional specificity.
Nature 1991;354(6349):149-52.
1991: M E Wilke; J N Higaki; Charles S Craik; Robert J Fletterick
Crystallographic analysis of trypsin-G226A. A specificity pocket mutant of rat trypsin with altered binding and catalysis.
Journal of molecular biology 1991;219(3):525-32.
1991: M E Wilke; J N Higaki; Charles S Craik; Robert J Fletterick
Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases.
Journal of molecular biology 1991;219(3):511-23.
1991: M E McGrath; W M Hines; Judy A Sakanari; Robert J Fletterick; Charles S Craik
The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli.
The Journal of biological chemistry 1991;266(10):6620-5.
1991: L M Babé; S Pichuantes; Charles S Craik
Inhibition of HIV protease activity by heterodimer formation.
Biochemistry 1991;30(1):106-11.
1991: Alfredo G Tomasselli; W J Howe; J O Hui; T K Sawyer; I M Reardon; D L DeCamp; Charles S Craik; Robert L Heinrikson
Calcium-free calmodulin is a substrate of proteases from human immunodeficiency viruses 1 and 2.
Proteins 1991;10(1):1-9.
1991: T Earnest; E Fauman; Charles S Craik; R Stroud
1.59 A structure of trypsin at 120 K: comparison of low temperature and room temperature structures.
Proteins 1991;10(3):171-87.
1991: D L Sloane; R A Dixon; Charles S Craik; E Sigal
Expression of cloned human 15-lipoxygenase in eukaryotic and prokaryotic systems.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():25-8.
1991: L M Babé; Charles S Craik
Time dependent heterodimer formation leads to inhibition of HIV protease activity.
Advances in experimental medicine and biology 1991;306():543-7.
1991: D L DeCamp; L M Babé; P Furth; Paul R. Ortiz de Montellano; Irwin D Kuntz; Charles S Craik
Structure-based inhibition of HIV-1 protease activity and viral infectivity.
Advances in experimental medicine and biology 1991;306():489-92.
1990: J N Higaki; B L Haymore; S Chen; Robert J Fletterick; Charles S Craik
Regulation of serine protease activity by an engineered metal switch.
Biochemistry 1990;29(37):8582-6.
1990: I C Bathurst; L K Moen; M A Lujan; H L Gibson; P H Feucht; S Pichuantes; Charles S Craik; D V Santi; P J Barr
Characterization of the human immunodeficiency virus type-1 reverse transcriptase enzyme produced in yeast.
Biochemical and biophysical research communications 1990;171(2):589-95.
1990: L B Evnin; J R Vásquez; Charles S Craik
Substrate specificity of trypsin investigated by using a genetic selection.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6659-63.
1990: R L DesJarlais; G L Seibel; Irwin D Kuntz; P S Furth; Juan Alvarez; Paul R. Ortiz de Montellano; D L DeCamp; L M Babé; Charles S Craik
Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6644-8.
1990: Alfredo G Tomasselli; J O Hui; T K Sawyer; D J Staples; C Bannow; I M Reardon; W J Howe; D L DeCamp; Charles S Craik; Robert L Heinrikson
Specificity and inhibition of proteases from human immunodeficiency viruses 1 and 2.
The Journal of biological chemistry 1990;265(24):14675-83.
1990: S Pichuantes; L M Babé; P J Barr; D L DeCamp; Charles S Craik
Recombinant HIV2 protease processes HIV1 Pr53gag and analogous junction peptides in vitro.
The Journal of biological chemistry 1990;265(23):13890-8.
1990: P Vanderslice; S M Ballinger; E K Tam; S M Goldstein; Charles S Craik; George H Caughey
Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3811-5.
1990: E A Stewart; Charles S Craik; L Hake; A M Bowcock
Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter.
American journal of human genetics 1990;46(4):795-800.
1990: A L Ferris; Amnon Hizi; S D Showalter; S Pichuantes; L Babe; Charles S Craik; Stephen H Hughes
Immunologic and proteolytic analysis of HIV-1 reverse transcriptase structure.
Virology 1990;175(2):456-64.
1990: E Sigal; dorit grunberger; E Highland; C Gross; R A Dixon; Charles S Craik
Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related.
The Journal of biological chemistry 1990;265(9):5113-20.
1990: A E Eakin; J Bouvier; Judy A Sakanari; Charles S Craik; James H McKerrow
Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites.
Molecular and biochemical parasitology 1990;39(1):1-8.
1990: D L Sloane; Charles S Craik; E Sigal
The expression of active human reticulocyte 15-lipoxygenase in bacteria.
Biomedica biochimica acta 1990;49(2-3):S11-6.
1989: M E McGrath; M E Wilke; J N Higaki; Charles S Craik; Robert J Fletterick
Crystal structures of two engineered thiol trypsins.
Biochemistry 1989;28(24):9264-70.
1989: J N Higaki; L B Evnin; Charles S Craik
Introduction of a cysteine protease active site into trypsin.
Biochemistry 1989;28(24):9256-63.
1989: Judy A Sakanari; C E Staunton; A E Eakin; Charles S Craik; James H McKerrow
Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):4863-7.
1989: P Vanderslice; Charles S Craik; Jay A Nadel; George H Caughey
Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation.
Biochemistry 1989;28(10):4148-55.
1989: J R Vasquez; L B Evnin; J N Higaki; Charles S Craik
An expression system for trypsin.
Journal of cellular biochemistry 1989;39(3):265-76.
1989: M E McGrath; Robert J Fletterick; Charles S Craik
Rapid preparation of proteins for crystallization trials.
BioTechniques 1989;7(3):246-7.
1989: S Pichuantes; L M Babé; P J Barr; Charles S Craik
Recombinant HIV1 protease secreted by Saccharomyces cerevisiae correctly processes myristylated gag polyprotein.
Proteins 1989;6(3):324-37.
1989: E Sigal; Charles S Craik; R A Dixon; Jay A Nadel
Cloning and expression of human arachidonate 15-lipoxygenase.
Transactions of the Association of American Physicians 1989;102():176-84.
1989: E Sigal; dorit grunberger; Charles S Craik; George H Caughey; Jay A Nadel
Arachidonate 15-lipoxygenase from human leukocytes: purification and structural homology to other mammalian lipoxygenases.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():156-9.
1988: E Sigal; Charles S Craik; E Highland; dorit grunberger; L L Costello; R A Dixon; Jay A Nadel
Molecular cloning and primary structure of human 15-lipoxygenase.
Biochemical and biophysical research communications 1988;157(2):457-64.
1988: László Gráf; G Hegyi; István Likó; J Hepp; Katalin F Medzihradszky; Charles S Craik; W J Rutter
Structural and functional integrity of specificity and catalytic sites of trypsin.
International journal of peptide and protein research 1988;32(6):512-8.
1988: E Clauser; S J Gardell; Charles S Craik; R J MacDonald; W J Rutter
Structural characterization of the rat carboxypeptidase A1 and B genes. Comparative analysis of the rat carboxypeptidase gene family.
The Journal of biological chemistry 1988;263(33):17837-45.
1988: S J Gardell; Charles S Craik; E Clauser; Elizabeth J Goldsmith; Caro-Beth Stewart; M Graf; W J Rutter
A novel rat carboxypeptidase, CPA2: characterization, molecular cloning, and evolutionary implications on substrate specificity in the carboxypeptidase gene family.
The Journal of biological chemistry 1988;263(33):17828-36.
1988: S K Powell; L Orci; Charles S Craik; Hsiao-Ping H Moore
Efficient targeting to storage granules of human proinsulins with altered propeptide domain.
The Journal of cell biology 1988;106(6):1843-51.
1988: E Sigal; dorit grunberger; Charles S Craik; George H Caughey; Jay A Nadel
Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases.
The Journal of biological chemistry 1988;263(11):5328-32.
1988: E Sigal; dorit grunberger; J R Cashman; Charles S Craik; George H Caughey; Jay A Nadel
Arachidonate 15-lipoxygenase from human eosinophil-enriched leukocytes: partial purification and properties.
Biochemical and biophysical research communications 1988;150(1):376-83.
1988: L B Evnin; Charles S Craik
Development of an efficient method for generating and screening active trypsin and trypsin variants.
Annals of the New York Academy of Sciences 1988;542():61-74.
1988: S R Sprang; Robert J Fletterick; László Gráf; W J Rutter; Charles S Craik
Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants.
Critical reviews in biotechnology 1988;8(3):225-36.
1987: Charles S Craik; S Roczniak; C Largman; W J Rutter
The catalytic role of the active site aspartic acid in serine proteases.
Science (New York, N.Y.) 1987;237(4817):909-13.
1987: Stephen R Sprang; T Standing; Robert J Fletterick; Robert M Stroud; J Finer-Moore; Nguyen-Huu Xuong; R Hamlin; W J Rutter; Charles S Craik
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis.
Science (New York, N.Y.) 1987;237(4817):905-9.
1987: T L Burgess; Charles S Craik; L Matsuuchi; R B Kelly
In vitro mutagenesis of trypsinogen: role of the amino terminus in intracellular protein targeting to secretory granules.
The Journal of cell biology 1987;105(2):659-68.
1987: T S Fletcher; M Alhadeff; Charles S Craik; C Largman
Isolation and characterization of a cDNA encoding rat cationic trypsinogen.
Biochemistry 1987;26(11):3081-6.
1987: László Gráf; Charles S Craik; A Patthy; S Roczniak; Robert J Fletterick; W J Rutter
Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin.
Biochemistry 1987;26(9):2616-23.
1987: Charles S Craik; S Roczniak; S Sprang; Robert J Fletterick; W Rutter
Redesigning trypsin via genetic engineering.
Journal of cellular biochemistry 1987;33(3):199-211.
1987: Y Ebina; E Araki; M Taira; F Shimada; M Mori; Charles S Craik; K Siddle; S B Pierce; R A Roth; W J Rutter
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(3):704-8.
1987: J N Higaki; B W Gibson; Charles S Craik
Evolution of catalysis in the serine proteases.
Cold Spring Harbor symposia on quantitative biology 1987;52():615-21.
1985: S J Gardell; Charles S Craik; D Hilvert; M S Urdea; W J Rutter
Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis.
Nature 1985;317(6037):551-5.
1985: T L Burgess; Charles S Craik; R B Kelly
The exocrine protein trypsinogen is targeted into the secretory granules of an endocrine cell line: studies by gene transfer.
The Journal of cell biology 1985;101(2):639-45.
1985: Charles S Craik; C Largman; T Fletcher; S Roczniak; P J Barr; Robert J Fletterick; W J Rutter
Redesigning trypsin: alteration of substrate specificity.
Science (New York, N.Y.) 1985;228(4697):291-7.
1984: G I Bell; C Quinto; M Quiroga; P Valenzuela; Charles S Craik; W J Rutter
Isolation and sequence of a rat chymotrypsin B gene.
The Journal of biological chemistry 1984;259(22):14265-70.
1984: Galvin Swift; Charles S Craik; S J Stary; C Quinto; R G Lahaie; W J Rutter; Raymond J MacDonald
Structure of the two related elastase genes expressed in the rat pancreas.
The Journal of biological chemistry 1984;259(22):14271-8.
1984: Charles S Craik; Q L Choo; Galvin Swift; C Quinto; Raymond J MacDonald; W J Rutter
Structure of two related rat pancreatic trypsin genes.
The Journal of biological chemistry 1984;259(22):14255-64.
1983: Charles S Craik; W J Rutter; Robert J Fletterick
Splice junctions: association with variation in protein structure.
Science (New York, N.Y.) 1983;220(4602):1125-9.
1982: Charles S Craik; S Sprang; Robert J Fletterick; W J Rutter
Intron-exon splice junctions map at protein surfaces.
Nature 1982;299(5879):180-2.
1981: Charles S Craik; Steven R Buchman; S Beychok
O2 binding properties of the product of the central exon of beta-globin gene.
Nature 1981;291(5810):87-90.
1980: Charles S Craik; I Vallette; S Beychok; M Waks
Refolding defects in hemoglobin Rothschild.
The Journal of biological chemistry 1980;255(13):6219-23.
1980: Charles S Craik; Steven R Buchman; S Beychok
Characterization of globin domains: heme binding to the central exon product.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(3):1384-8.