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Charles Craik

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
37
Fletterick, Robert
16
Choe, Youngchool
16
McKerrow, James
10
Harris, Jennifer
9
Ortiz de Montellano, Paul R.
8
Stroud, Robert
8
Ellman, Jonathan
8
Shimba, Nobuhisa
8
Kuntz, Irwin
8
Mahrus, Sami
7
Nomura, Anson
6
McPhee, F
6
Nadel, Jay
6
Marnett, Alan
6
Dauber, Deborah

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Publications

TOP 3
Mahon Cathal S; O'Donoghue Anthony J; Goetz David H; Murray Patrick G; Craik Charles S; Tuohy Maria G
Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii.
Jun Young-wook; Sheikholeslami Sassan; Hostetter Daniel R; Tajon Cheryl; Craik Charles S; Alivisatos A Paul
Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level.
Shahian Tina; Lee Gregory M; Lazic Ana; Arnold Leggy A; Velusamy Priya; Roels Christina M; Guy R Kiplin; Craik Charles S
Inhibition of a viral enzyme by a small-molecule dimer disruptor.

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All Publications

2009: Mahon Cathal S; O'Donoghue Anthony J; Goetz David H; Murray Patrick G; Craik Charles S; Tuohy Maria G
Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii.
Microbiology (Reading, England) 2009;155(Pt 11):3673-82.
2009: Jun Young-wook; Sheikholeslami Sassan; Hostetter Daniel R; Tajon Cheryl; Craik Charles S; Alivisatos A Paul
Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(42):17735-40.
2009: Shahian Tina; Lee Gregory M; Lazic Ana; Arnold Leggy A; Velusamy Priya; Roels Christina M; Guy R Kiplin; Craik Charles S
Inhibition of a viral enzyme by a small-molecule dimer disruptor.
Nature chemical biology 2009;5(9):640-6.
2009: Kerr Iain D; Lee Ji H; Farady Christopher J; Marion Rachael; Rickert Mathias; Sajid Mohammed; Pandey Kailash C; Caffrey Conor R; Legac Jennifer; Hansell Elizabeth; McKerrow James H; Craik Charles S; Rosenthal Philip J; Brinen Linda S
Vinyl sulfones as antiparasitic agents and a structural basis for drug design.
The Journal of biological chemistry 2009;284(38):25697-703.
2009: McKerrow J H; Doyle P S; Engel J C; Podust L M; Robertson S A; Ferreira R; Saxton T; Arkin M; Kerr I D; Brinen L S; Craik C S
Two approaches to discovering and developing new drugs for Chagas disease.
Memórias do Instituto Oswaldo Cruz 2009;104 Suppl 1():263-9.
2009: Farady Christopher J; Sellers Benjamin D; Jacobson Matthew P; Craik Charles S
Improving the species cross-reactivity of an antibody using computational design.
Bioorganic & medicinal chemistry letters 2009;19(14):3744-7.
2009: Lilla Jennifer N; Joshi Ravi V; Craik Charles S; Werb Zena
Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution.
The Journal of biological chemistry 2009;284(20):13792-803.
2009: Lee Gregory M; Craik Charles S
Trapping moving targets with small molecules.
Science (New York, N.Y.) 2009;324(5924):213-5.
2009: Liz Márcia A; Fleming Carolina E; Nunes Ana F; Almeida Maria R; Mar Fernando M; Choe Youngchool; Craik Charles S; Powers James C; Bogyo Matthew; Sousa Mónica M
Substrate specificity of transthyretin: identification of natural substrates in the nervous system.
The Biochemical journal 2009;419(2):467-74.
2009: Lim Mark D; Craik Charles S
Using specificity to strategically target proteases.
Bioorganic & medicinal chemistry 2009;17(3):1094-100.
2009: Dvorák Jan; Mashiyama Susan T; Sajid Mohammed; Braschi Simon; Delcroix Melaine; Schneider Eric L; McKerrow Wilson H; Bahgat Mahmoud; Hansell Elizabeth; Babbitt Patricia C; Craik Charles S; McKerrow James H; Caffrey Conor R
SmCL3, a Gastrodermal Cysteine Protease of the Human Blood Fluke Schistosoma mansoni.
PLoS neglected tropical diseases 2009;3(6):e449.
2009: Schneider Eric L; Craik Charles S
Positional scanning synthetic combinatorial libraries for substrate profiling.
Methods in molecular biology (Clifton, N.J.) 2009;539():59-78.
2009: Subramanian Shoba; Hardt Markus; Choe Youngchool; Niles Richard K; Johansen Eric B; Legac Jennifer; Gut Jiri; Kerr Iain D; Craik Charles S; Rosenthal Philip J
Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.
PloS one 2009;4(4):e5156.
2008: O'Brien Theresa C; Mackey Zachary B; Fetter Richard D; Choe Youngchool; O'Donoghue Anthony J; Zhou Min; Craik Charles S; Caffrey Conor R; McKerrow James H
A parasite cysteine protease is key to host protein degradation and iron acquisition.
The Journal of biological chemistry 2008;283(43):28934-43.
2008: Raorane Digvijay A; Lim Mark D; Chen Fanqing Frank; Craik Charles S; Majumdar Arun
Quantitative and label-free technique for measuring protease activity and inhibition using a microfluidic cantilever array.
Nano letters 2008;8(9):2968-74.
2008: Farady Christopher J; Egea Pascal F; Schneider Eric L; Darragh Molly R; Craik Charles S
Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition.
Journal of molecular biology 2008;380(2):351-60.
2008: Debela Mekdes; Beaufort Nathalie; Magdolen Viktor; Schechter Norman M; Craik Charles S; Schmitt Manfred; Bode Wolfram; Goettig Peter
Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7.
Biological chemistry 2008;389(6):623-32.
2008: Stack Colin M; Caffrey Conor R; Donnelly Sheila M; Seshaadri Amritha; Lowther Jonathan; Tort Jose F; Collins Peter R; Robinson Mark W; Xu Weibo; McKerrow James H; Craik Charles S; Geiger Sebastian R; Marion Rachel; Brinen Linda S; Dalton John P
Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica.
The Journal of biological chemistry 2008;283(15):9896-908.
2008: Darragh Molly R; Bhatt Ami S; Craik Charles S
MT-SP1 proteolysis and regulation of cell-microenvironment interactions.
Frontiers in bioscience : a journal and virtual library 2008;13():528-39.
2007: Lazic Ana; Goetz David H; Nomura Anson M; Marnett Alan B; Craik Charles S
Substrate modulation of enzyme activity in the herpesvirus protease family.
Journal of molecular biology 2007;373(4):913-23.
2007: Hostetter Daniel R; Loeb Carly R K; Chu Feixia; Craik Charles S
Hip is a pro-survival substrate of granzyme B.
The Journal of biological chemistry 2007;282(38):27865-74.
2007: Goetz D H; Choe Y; Hansell E; Chen Y T; McDowell M; Jonsson C B; Roush W R; McKerrow J; Craik C S
Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus.
Biochemistry 2007;46(30):8744-52.
2007: Farady Christopher J; Sun Jeonghoon; Darragh Molly R; Miller Susan M; Craik Charles S
The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1).
Journal of molecular biology 2007;369(4):1041-51.
2007: Sojka Daniel; Hajdusek Ondrej; Dvorák Jan; Sajid Mohammed; Franta Zdenek; Schneider Eric L; Craik Charles S; Vancová Marie; Buresová Veronika; Bogyo Matthew; Sexton Kelly B; McKerrow James H; Caffrey Conor R; Kopácek Petr
IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus.
International journal for parasitology 2007;37(7):713-24.
2007: Bhatt Ami S; Welm Alana; Farady Christopher J; Vásquez Maximiliano; Wilson Keith; Craik Charles S
Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5771-6.
2006: Park Kyewhan; Kuechle Melanie K; Choe Youngchool; Craik Charles S; Lawrence Owen T; Presland Richard B
Expression and characterization of constitutively active human caspase-14.
Biochemical and biophysical research communications 2006;347(4):941-8.
2006: Loeb Carly R K; Harris Jennifer L; Craik Charles S
Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis.
The Journal of biological chemistry 2006;281(38):28326-35.
2006: Debela Mekdes; Magdolen Viktor; Schechter Norman; Valachova Martina; Lottspeich Friedrich; Craik Charles S; Choe Youngchool; Bode Wolfram; Goettig Peter
Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences.
The Journal of biological chemistry 2006;281(35):25678-88.
2006: Chu Feixia; Mahrus Sami; Craik Charles S; Burlingame Alma L
Isotope-coded and affinity-tagged cross-linking (ICATXL): an efficient strategy to probe protein interaction surfaces.
Journal of the American Chemical Society 2006;128(32):10362-3.
2006: Lund Leif R; Green Kirsty A; Stoop Allart A; Ploug Michael; Almholt Kasper; Lilla Jennifer; Nielsen Boye S; Christensen Ib J; Craik Charles S; Werb Zena; Danø Keld; Rømer John
Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.
The EMBO journal 2006;25(12):2686-97.
2006: Baird Teaster T; Wright William D; Craik Charles S
Conversion of trypsin to a functional threonine protease.
Protein science : a publication of the Protein Society 2006;15(6):1229-38.
2006: Choe Youngchool; Leonetti Francesco; Greenbaum Doron C; Lecaille Fabien; Bogyo Matthew; Brömme Dieter; Ellman Jonathan A; Craik Charles S
Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities.
The Journal of biological chemistry 2006;281(18):12824-32.
2006: Nomura Anson M; Marnett Alan B; Shimba Nobuhisa; Dötsch Volker; Craik Charles S
One functional switch mediates reversible and irreversible inactivation of a herpesvirus protease.
Biochemistry 2006;45(11):3572-9.
2005: Nomura Anson M; Marnett Alan B; Shimba Nobuhisa; Dötsch Volker; Craik Charles S
Induced structure of a helical switch as a mechanism to regulate enzymatic activity.
Nature structural & molecular biology 2005;12(11):1019-20.
2005: Bhatt Ami S; Erdjument-Bromage Hediye; Tempst Paul; Craik Charles S; Moasser Mark M
Adhesion signaling by a novel mitotic substrate of src kinases.
Oncogene 2005;24(34):5333-43.
2005: Herter Sylvia; Piper Derek E; Aaron Wade; Gabriele Timothy; Cutler Gene; Cao Ping; Bhatt Ami S; Choe Youngchool; Craik Charles S; Walker Nigel; Meininger David; Hoey Timothy; Austin Richard J
Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers.
The Biochemical journal 2005;390(Pt 1):125-36.
2005: Mahrus Sami; Craik Charles S
Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells.
Chemistry & biology 2005;12(5):567-77.
2005: Choe Youngchool; Brinen Linda S; Price Mark S; Engel Juan C; Lange Meinolf; Grisostomi Corinna; Weston Scott G; Pallai Peter V; Cheng Hong; Hardy Larry W; Hartsough David S; McMakin Marsha; Tilton Robert F; Baldino Carmen M; Craik Charles S
Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease.
Bioorganic & medicinal chemistry 2005;13(6):2141-56.
2005: Marnett Alan B; Craik Charles S
Papa's got a brand new tag: advances in identification of proteases and their substrates.
Trends in biotechnology 2005;23(2):59-64.
2005: Matsumura Masazumi; Bhatt Ami S; Andress Dennis; Clegg Nigel; Takayama Thomas K; Craik Charles S; Nelson Peter S
Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries.
The Prostate 2005;62(1):1-13.
2004: Mahrus Sami; Kisiel Walter; Craik Charles S
Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B.
The Journal of biological chemistry 2004;279(52):54275-82.
2004: Shimba Nobuhisa; Kovacs Helena; Stern Alan S; Nomura Anson M; Shimada Ichio; Hoch Jeffrey C; Craik Charles S; Dötsch Volker
Optimization of 13C direct detection NMR methods.
Journal of biomolecular NMR 2004;30(2):175-9.
2004: Williamson Angela L; Lecchi Paolo; Turk Benjamin E; Choe Youngchool; Hotez Peter J; McKerrow James H; Cantley Lewis C; Sajid Mohammed; Craik Charles S; Loukas Alex
A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms.
The Journal of biological chemistry 2004;279(34):35950-7.
2004: Ruggles Sandra Waugh; Fletterick Robert J; Craik Charles S
Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity.
The Journal of biological chemistry 2004;279(29):30751-9.
2004: Serber Zach; Straub Wesley; Corsini Lorenzo; Nomura Anson M; Shimba Nobuhisa; Craik Charles S; Ortiz de Montellano Paul; Dötsch Volker
Methyl groups as probes for proteins and complexes in in-cell NMR experiments.
Journal of the American Chemical Society 2004;126(22):7119-25.
2004: Shimba Nobuhisa; Nomura Anson M; Marnett Alan B; Craik Charles S
Herpesvirus protease inhibition by dimer disruption.
Journal of virology 2004;78(12):6657-65.
2004: Marnett Alan B; Nomura Anson M; Shimba Nobuhisa; Ortiz de Montellano Paul R; Craik Charles S
Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(18):6870-5.
2004: Eggers Christopher T; Murray Iain A; Delmar Valerie A; Day Anthony G; Craik Charles S
The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase.
The Biochemical journal 2004;379(Pt 1):107-18.
2004: Na Byoung-Kuk; Shenai Bhaskar R; Sijwali Puran S; Choe Youngchool; Pandey Kailash C; Singh Ajay; Craik Charles S; Rosenthal Philip J
Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax.
The Biochemical journal 2004;378(Pt 2):529-38.
2003: Stoop A Allart; Craik Charles S
Engineering of a macromolecular scaffold to develop specific protease inhibitors.
Nature biotechnology 2003;21(9):1063-8.
2003: Raymond Wilfred W; Ruggles Sandra Waugh; Craik Charles S; Caughey George H
Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site.
The Journal of biological chemistry 2003;278(36):34517-24.
2003: Shimba Nobuhisa; Serber Zach; Ledwidge Richard; Miller Susan M; Craik Charles S; Dötsch Volker
Quantitative identification of the protonation state of histidines in vitro and in vivo.
Biochemistry 2003;42(30):9227-34.
2003: Bell Jessica K; Goetz David H; Mahrus Sami; Harris Jennifer L; Fletterick Robert J; Craik Charles S
The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity.
Nature structural biology 2003;10(7):527-34.
2003: Leiting Barbara; Pryor KellyAnn D; Wu Joseph K; Marsilio Frank; Patel Reshma A; Craik Charles S; Ellman Jonathan A; Cummings Richard T; Thornberry Nancy A
Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII.
The Biochemical journal 2003;371(Pt 2):525-32.
2003: Mackewicz Carl E; Craik Charles S; Levy Jay A
The CD8+ cell noncytotoxic anti-HIV response can be blocked by protease inhibitors.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(6):3433-8.
2003: Shimba Nobuhisa; Stern Alan S; Craik Charles S; Hoch Jeffrey C; Dötsch Volker
Elimination of 13Calpha splitting in protein NMR spectra by deconvolution with maximum entropy reconstruction.
Journal of the American Chemical Society 2003;125(9):2382-3.
2003: Bhatt Ami S; Takeuchi Toshi; Ylstra Bauke; Ginzinger David; Albertson Donna; Shuman Marc A; Craik Charles S
Quantitation of membrane type serine protease 1 (MT-SP1) in transformed and normal cells.
Biological chemistry 2003;384(2):257-66.
2003: Sun Jeonghoon; Pons Jaume; Craik Charles S
Potent and selective inhibition of membrane-type serine protease 1 by human single-chain antibodies.
Biochemistry 2003;42(4):892-900.
2002: Barrios Amy M; Craik Charles S
Scanning the prime-site substrate specificity of proteolytic enzymes: a novel assay based on ligand-enhanced lanthanide ion fluorescence.
Bioorganic & medicinal chemistry letters 2002;12(24):3619-23.
2002: Singh Ajay; Shenai Bhaskar R; Choe Youngchool; Gut Jiri; Sijwali Puran S; Craik Charles S; Rosenthal Philip J
Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites.
The Biochemical journal 2002;368(Pt 1):273-81.
2002: Wang Xueqing; Choe Youngchool; Craik Charles S; Ellman Jonathan A
Design and synthesis of novel inhibitors of gelatinase B.
Bioorganic & medicinal chemistry letters 2002;12(16):2201-4.
2002: Lecaille Fabien; Choe Youngchool; Brandt Wolfgang; Li Zhenqiang; Craik Charles S; Brömme Dieter
Selective inhibition of the collagenolytic activity of human cathepsin K by altering its S2 subsite specificity.
Biochemistry 2002;41(26):8447-54.
2002: Salter Jason P; Choe Youngchool; Albrecht Hugo; Franklin Christopher; Lim Kee-Chong; Craik Charles S; McKerrow James H
Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes.
The Journal of biological chemistry 2002;277(27):24618-24.
2002: Laboissière Martha C A; Young Malin M; Pinho Rilva G; Todd Stephen; Fletterick Robert J; Kuntz Irwin; Craik Charles S
Computer-assisted mutagenesis of ecotin to engineer its secondary binding site for urokinase inhibition.
The Journal of biological chemistry 2002;277(29):26623-31.
2002: Mathieu Mary A; Bogyo Matthew; Caffrey Conor R; Choe Youngchool; Lee Jewok; Chapman Harold; Sajid Mohammed; Craik Charles S; McKerrow James H
Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries.
Molecular and biochemical parasitology 2002;121(1):99-105.
2002: Reiling K Kinkead; Endres Nicholas F; Dauber Deborah S; Craik Charles S; Stroud Robert M
Anisotropic dynamics of the JE-2147-HIV protease complex: drug resistance and thermodynamic binding mode examined in a 1.09 A structure.
Biochemistry 2002;41(14):4582-94.
2002: Maly Dustin J; Leonetti Francesco; Backes Bradley J; Dauber Deborah S; Harris Jennifer L; Craik Charles S; Ellman Jonathan A
Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.
The Journal of organic chemistry 2002;67(3):910-5.
2002: Wang Bixun; Brown Kathlynn C; Lodder Michiel; Craik Charles S; Hecht Sidney M
Chemically mediated site-specific proteolysis. Alteration of protein-protein interaction.
Biochemistry 2002;41(8):2805-13.
2002: Pray Todd R; Reiling K Kinkead; Demirjian Berj G; Craik Charles S
Conformational change coupling the dimerization and activation of KSHV protease.
Biochemistry 2002;41(5):1474-82.
2002: Dauber Deborah S; Ziermann Rainer; Parkin Neil; Maly Dustin J; Mahrus Sami; Harris Jennifer L; Ellman Jon A; Petropoulos Christos; Craik Charles S
Altered substrate specificity of drug-resistant human immunodeficiency virus type 1 protease.
Journal of virology 2002;76(3):1359-68.
2001: Harris J L; Niles A; Burdick K; Maffitt M; Backes B J; Ellman J A; Kuntz I; Haak-Frendscho M; Craik C S
Definition of the extended substrate specificity determinants for beta-tryptases I and II.
The Journal of biological chemistry 2001;276(37):34941-7.
2001: Person M D; Brown K C; Mahrus S; Craik C S; Burlingame A L
Novel inter-protein cross-link identified in the GGH-ecotin D137Y dimer.
Protein science : a publication of the Protein Society 2001;10(8):1549-62.
2001: Eggers C T; Wang S X; Fletterick R J; Craik C S
The role of ecotin dimerization in protease inhibition.
Journal of molecular biology 2001;308(5):975-91.
2001: Selvarajan S; Lund L R; Takeuchi T; Craik C S; Werb Z
A plasma kallikrein-dependent plasminogen cascade required for adipocyte differentiation.
Nature cell biology 2001;3(3):267-75.
2001: Nealon K; Newcomb W W; Pray T R; Craik C S; Brown J C; Kedes D H
Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus.
Journal of virology 2001;75(6):2866-78.
2000: Reiling K K; Pray T R; Craik C S; Stroud R M
Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements.
Biochemistry 2000;39(42):12796-803.
2000: Waugh S M; Harris J L; Fletterick R; Craik C S
The structure of the pro-apoptotic protease granzyme B reveals the molecular determinants of its specificity.
Nature structural biology 2000;7(9):762-5.
2000: Takeuchi T; Harris J L; Huang W; Yan K W; Coughlin S R; Craik C S
Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates.
The Journal of biological chemistry 2000;275(34):26333-42.
2000: Harris J L; Backes B J; Leonetti F; Mahrus S; Ellman J A; Craik C S
Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):7754-9.
2000: Gillmor S A; Takeuchi T; Yang S Q; Craik C S; Fletterick R J
Compromise and accommodation in ecotin, a dimeric macromolecular inhibitor of serine proteases.
Journal of molecular biology 2000;299(4):993-1003.
2000: Todd S; Anderson C; Jolly D J; Craik C S
HIV protease as a target for retrovirus vector-mediated gene therapy.
Biochimica et biophysica acta 2000;1477(1-2):168-88.
2000: Rozzelle J E; Dauber D S; Todd S; Kelley R; Craik C S
Macromolecular inhibitors of HIV-1 protease. Characterization of designed heterodimers.
The Journal of biological chemistry 2000;275(10):7080-6.
2000: Sambrano G R; Huang W; Faruqi T; Mahrus S; Craik C; Coughlin S R
Cathepsin G activates protease-activated receptor-4 in human platelets.
The Journal of biological chemistry 2000;275(10):6819-23.
2000: Backes B J; Harris J L; Leonetti F; Craik C S; Ellman J A
Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin.
Nature biotechnology 2000;18(2):187-93.
2000: Todd S; Laboissière M C; Craik C S
Yeast two-hybrid assay for examining human immunodeficiency virus protease heterodimer formation with dominant-negative inhibitors and multidrug-resistant variants.
Analytical biochemistry 2000;277(2):247-53.
1999: Takeuchi T; Shuman M A; Craik C S
Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11054-61.
1999: Pray T R; Nomura A M; Pennington M W; Craik C S
Auto-inactivation by cleavage within the dimer interface of Kaposi's sarcoma-associated herpesvirus protease.
Journal of molecular biology 1999;289(2):197-203.
1998: Harris J L; Peterson E P; Hudig D; Thornberry N A; Craik C S
Definition and redesign of the extended substrate specificity of granzyme B.
The Journal of biological chemistry 1998;273(42):27364-73.
1998: Yang S Q; Craik C S
Engineering bidentate macromolecular inhibitors for trypsin and urokinase-type plasminogen activator.
Journal of molecular biology 1998;279(4):1001-11.
1998: Yang S Q; Wang C I; Gillmor S A; Fletterick R J; Craik C S
Ecotin: a serine protease inhibitor with two distinct and interacting binding sites.
Journal of molecular biology 1998;279(4):945-57.
1998: Brown K C; Yu Z; Burlingame A L; Craik C S
Determining protein-protein interactions by oxidative cross-linking of a glycine-glycine-histidine fusion protein.
Biochemistry 1998;37(13):4397-406.
1998: Harris J L; Craik C S
Engineering enzyme specificity.
Current opinion in chemical biology 1998;2(1):127-32.
1998: Rose R B; Craik C S; Stroud R M
Domain flexibility in retroviral proteases: structural implications for drug resistant mutations.
Biochemistry 1998;37(8):2607-21.
1998: Dauber D S; McPhee F; Unal A; Craik C S
Optimization of a macromolecular inhibitor of HIV-1 protease.
Advances in experimental medicine and biology 1998;436():65-70.
1998: Craik C S; Babé L M; Dauber D; McPhee F; Rosé J; Unal A
Engineering catalytically defective forms of HIV protease to modulate its activity.
Advances in experimental medicine and biology 1998;436():31-9.
1997: Caldera P S; Yu Z; Knegtel R M; McPhee F; Burlingame A L; Craik C S; Kuntz I D; Ortiz de Montellano P R
Alkylation of a catalytic aspartate group of the SIV protease by an epoxide inhibitor.
Bioorganic & medicinal chemistry 1997;5(11):2019-27.
1997: Babé L M; Craik C S
Viral proteases: evolution of diverse structural motifs to optimize function.
Cell 1997;91(4):427-30.
1997: Perona J J; Craik C S
Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold.
The Journal of biological chemistry 1997;272(48):29987-90.
1997: Unal A; Pray T R; Lagunoff M; Pennington M W; Ganem D; Craik C S
The protease and the assembly protein of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8).
Journal of virology 1997;71(9):7030-8.
1997: Gillmor S A; Craik C S; Fletterick R J
Structural determinants of specificity in the cysteine protease cruzain.
Protein science : a publication of the Protein Society 1997;6(8):1603-11.
1997: Rutenber E E; De Voss J J; Hoffman L; Stroud R M; Lee K H; Alvarez J; McPhee F; Craik C; Ortiz de Montellano P R
The discovery, characterization and crystallographically determined binding mode of an FMOC-containing inhibitor of HIV-1 protease.
Bioorganic & medicinal chemistry 1997;5(7):1311-20.
1997: Babé L M; Unal A; Craik C S
Obstruction of HIV-1 particle release by interferon-alpha occurs before viral protease processing and is independent of envelope glycoprotein.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1997;17(5):287-93.
1997: Tsu C A; Perona J J; Fletterick R J; Craik C S
Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1.
Biochemistry 1997;36(18):5393-401.
1997: Perona J J; Tsu C A; Craik C S; Fletterick R J
Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix.
Biochemistry 1997;36(18):5381-92.
1997: Ewoldt G R; Smyth M J; Darcy P K; Harris J L; Craik C S; Horowitz B; Woodard S L; Powers J C; Hudig D
P-4 and RNKP-7, new granzyme-like serine proteases expressed in activated rat lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4574-83.
1997: Kågedahl M; Swaan P W; Redemann C T; Tang M; Craik C S; Szoka F C; Oie S
Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity.
Pharmaceutical research 1997;14(2):176-80.
1996: McPhee F; Caldera P S; Bemis G W; McDonagh A F; Kuntz I D; Craik C S
Bile pigments as HIV-1 protease inhibitors and their effects on HIV-1 viral maturation and infectivity in vitro.
The Biochemical journal 1996;320 ( Pt 2)():681-6.
1996: Junker U; Escaich S; Plavec I; Baker J; McPhee F; Rose J R; Craik C S; Böhnlein E
Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.
Journal of virology 1996;70(11):7765-72.
1996: McPhee F; Good A C; Kuntz I D; Craik C S
Engineering human immunodeficiency virus 1 protease heterodimers as macromolecular inhibitors of viral maturation.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11477-81.
1996: Rose R B; Craik C S; Douglas N L; Stroud R M
Three-dimensional structures of HIV-1 and SIV protease product complexes.
Biochemistry 1996;35(39):12933-44.
1996: Rutenber E E; McPhee F; Kaplan A P; Gallion S L; Hogan J C; Craik C S; Stroud R M
A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere.
Bioorganic & medicinal chemistry 1996;4(9):1545-58.
1996: Li R; Chen X; Gong B; Selzer P M; Li Z; Davidson E; Kurzban G; Miller R E; Nuzum E O; McKerrow J H; Fletterick R J; Gillmor S A; Craik C S; Kuntz I D; Cohen F E; Kenyon G L
Structure-based design of parasitic protease inhibitors.
Bioorganic & medicinal chemistry 1996;4(9):1421-7.
1996: Brinen L S; Willett W S; Craik C S; Fletterick R J
X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
Biochemistry 1996;35(19):5999-6009.
1996: Willett W S; Brinen L S; Fletterick R J; Craik C S
Delocalizing trypsin specificity with metal activation.
Biochemistry 1996;35(19):5992-8.
1996: Tsu C A; Craik C S
Substrate recognition by recombinant serine collagenase 1 from Uca pugilator.
The Journal of biological chemistry 1996;271(19):11563-70.
1996: Gudmundsdóttir E; Spilliaert R; Yang Q; Craik C S; Bjarnason J B; Gudmundsdóttir A
Isolation and characterization of two cDNAs from Atlantic cod encoding two distinct psychrophilic elastases.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1996;113(4):795-801.
1996: Wang C I; Yang Q; Craik C S
Phage display of proteases and macromolecular inhibitors.
Methods in enzymology 1996;267():52-68.
1995: Liu S H; Wong M L; Craik C S; Brodsky F M
Regulation of clathrin assembly and trimerization defined using recombinant triskelion hubs.
Cell 1995;83(2):257-67.
1995: Babé L M; Rosé J; Craik C S
Trans-dominant inhibitory human immunodeficiency virus type 1 protease monomers prevent protease activation and virion maturation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10069-73.
1995: Corey D R; Willett W S; Coombs G S; Craik C S
Trypsin specificity increased through substrate-assisted catalysis.
Biochemistry 1995;34(36):11521-7.
1995: Wang C I; Yang Q; Craik C S
Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin.
The Journal of biological chemistry 1995;270(20):12250-6.
1995: Rosé J R; Babé L M; Craik C S
Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity.
Journal of virology 1995;69(5):2751-8.
1995: Perona J J; Craik C S
Structural basis of substrate specificity in the serine proteases.
Protein science : a publication of the Protein Society 1995;4(3):337-60.
1995: McGrath M E; Eakin A E; Engel J C; McKerrow J H; Craik C S; Fletterick R J
The crystal structure of cruzain: a therapeutic target for Chagas' disease.
Journal of molecular biology 1995;247(2):251-9.
1995: Sloane D L; Leung R; Barnett J; Craik C S; Sigal E
Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity.
Protein engineering 1995;8(3):275-82.
1995: Willett W S; Gillmor S A; Perona J J; Fletterick R J; Craik C S
Engineered metal regulation of trypsin specificity.
Biochemistry 1995;34(7):2172-80.
1994: Rosé J R; Craik C S
Structure-assisted design of nonpeptide human immunodeficiency virus-1 protease inhibitors.
American journal of respiratory and critical care medicine 1994;150(6 Pt 2):S176-82.
1994: Babé L M; Craik C S
Constitutive production of nonenveloped human immunodeficiency virus type 1 particles by a mammalian cell line and effects of a protease inhibitor on particle maturation.
Antimicrobial agents and chemotherapy 1994;38(10):2430-9.
1994: Guthmundsdóttir A; Oskarsson S; Eakin A E; Craik C S; Bjarnason J B
Atlantic cod cDNA encoding a psychrophilic chymotrypsinogen.
Biochimica et biophysica acta 1994;1219(1):211-4.
1994: Tsu C A; Perona J J; Schellenberger V; Turck C W; Craik C S
The substrate specificity of Uca pugilator collagenolytic serine protease 1 correlates with the bovine type I collagen cleavage sites.
The Journal of biological chemistry 1994;269(30):19565-72.
1994: Matthews B W; Craik C S; Neurath H
Can small cyclic peptides have the activity and specificity of proteolytic enzymes?
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4103-5.
1994: Salto R; Babé L M; Li J; Rosé J R; Yu Z; Burlingame A; De Voss J J; Sui Z; Ortiz de Montellano P; Craik C S
In vitro characterization of nonpeptide irreversible inhibitors of HIV proteases.
The Journal of biological chemistry 1994;269(14):10691-8.
1994: Perona J J; Hedstrom L; Wagner R L; Rutter W J; Craik C S; Fletterick R J
Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser.
Biochemistry 1994;33(11):3252-9.
1994: De Voss J J; Sui Z; DeCamp D L; Salto R; Babé L M; Craik C S; Ortiz de Montellano P R
Haloperidol-based irreversible inhibitors of the HIV-1 and HIV-2 proteases.
Journal of medicinal chemistry 1994;37(5):665-73.
1993: Perona J J; Evnin L B; Craik C S
A genetic selection elucidates structural determinants of arginine versus lysine specificity in trypsin.
Gene 1993;137(1):121-6.
1993: Sui Z; Salto R; Li J; Craik C; Ortiz de Montellano P R
Inhibition of the HIV-1 and HIV-2 proteases by curcumin and curcumin boron complexes.
Bioorganic & medicinal chemistry 1993;1(6):415-22.
1993: Rose R B; Rosé J R; Salto R; Craik C S; Stroud R M
Structure of the protease from simian immunodeficiency virus: complex with an irreversible nonpeptide inhibitor.
Biochemistry 1993;32(46):12498-507.
1993: Gudmundsdóttir A; Gudmundsdóttir E; Oskarsson S; Bjarnason J B; Eakin A K; Craik C S
Isolation and characterization of cDNAs from Atlantic cod encoding two different forms of trypsinogen.
European journal of biochemistry / FEBS 1993;217(3):1091-7.
1993: Perona J J; Craik C S; Fletterick R J
Locating the catalytic water molecule in serine proteases.
Science (New York, N.Y.) 1993;261(5121):620-2.
1993: Corey D R; Shiau A K; Yang Q; Janowski B A; Craik C S
Trypsin display on the surface of bacteriophage.
Gene 1993;128(1):129-34.
1993: Rosé J R; Salto R; Craik C S
Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutions.
The Journal of biological chemistry 1993;268(16):11939-45.
1993: Perona J J; Tsu C A; McGrath M E; Craik C S; Fletterick R J
Relocating a negative charge in the binding pocket of trypsin.
Journal of molecular biology 1993;230(3):934-49.
1993: Perona J J; Tsu C A; Craik C S; Fletterick R J
Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI.
Journal of molecular biology 1993;230(3):919-33.
1993: Eakin A E; McGrath M E; McKerrow J H; Fletterick R J; Craik C S
Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi.
The Journal of biological chemistry 1993;268(9):6115-8.
1993: McGrath M E; Haymore B L; Summers N L; Craik C S; Fletterick R J
Structure of an engineered, metal-actuated switch in trypsin.
Biochemistry 1993;32(8):1914-9.
1992: Babé L M; Rosé J; Craik C S
Synthetic "interface" peptides alter dimeric assembly of the HIV 1 and 2 proteases.
Protein science : a publication of the Protein Society 1992;1(10):1244-53.
1992: DeCamp D L; Babé L M; Salto R; Lucich J L; Koo M S; Kahl S B; Craik C S
Specific inhibition of HIV-1 protease by boronated porphyrins.
Journal of medicinal chemistry 1992;35(18):3426-8.
1992: Eakin A E; Mills A A; Harth G; McKerrow J H; Craik C S
The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi.
The Journal of biological chemistry 1992;267(11):7411-20.
1992: McGrath M E; Vásquez J R; Craik C S; Yang A S; Honig B; Fletterick R J
Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214.
Biochemistry 1992;31(12):3059-64.
1992: Erpel T; Hwang P; Craik C S; Fletterick R J; McGrath M E
Physical map location of the new Escherichia coli gene eco, encoding the serine protease inhibitor ecotin.
Journal of bacteriology 1992;174(5):1704.
1992: Higaki J N; Fletterick R J; Craik C S
Engineered metalloregulation in enzymes.
Trends in biochemical sciences 1992;17(3):100-4.
1991: Sloane D L; Leung R; Craik C S; Sigal E
A primary determinant for lipoxygenase positional specificity.
Nature 1991;354(6349):149-52.
1991: Wilke M E; Higaki J N; Craik C S; Fletterick R J
Crystallographic analysis of trypsin-G226A. A specificity pocket mutant of rat trypsin with altered binding and catalysis.
Journal of molecular biology 1991;219(3):525-32.
1991: Wilke M E; Higaki J N; Craik C S; Fletterick R J
Crystal structure of rat trypsin-S195C at -150 degrees C. Analysis of low activity of recombinant and semisynthetic thiol proteases.
Journal of molecular biology 1991;219(3):511-23.
1991: McGrath M E; Hines W M; Sakanari J A; Fletterick R J; Craik C S
The sequence and reactive site of ecotin. A general inhibitor of pancreatic serine proteases from Escherichia coli.
The Journal of biological chemistry 1991;266(10):6620-5.
1991: Babé L M; Pichuantes S; Craik C S
Inhibition of HIV protease activity by heterodimer formation.
Biochemistry 1991;30(1):106-11.
1991: Tomasselli A G; Howe W J; Hui J O; Sawyer T K; Reardon I M; DeCamp D L; Craik C S; Heinrikson R L
Calcium-free calmodulin is a substrate of proteases from human immunodeficiency viruses 1 and 2.
Proteins 1991;10(1):1-9.
1991: Earnest T; Fauman E; Craik C S; Stroud R
1.59 A structure of trypsin at 120 K: comparison of low temperature and room temperature structures.
Proteins 1991;10(3):171-87.
1991: Sloane D L; Dixon R A; Craik C S; Sigal E
Expression of cloned human 15-lipoxygenase in eukaryotic and prokaryotic systems.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21A():25-8.
1991: Babé L M; Craik C S
Time dependent heterodimer formation leads to inhibition of HIV protease activity.
Advances in experimental medicine and biology 1991;306():543-7.
1991: DeCamp D L; Babé L M; Furth P; Ortiz de Montellano P; Kuntz I D; Craik C S
Structure-based inhibition of HIV-1 protease activity and viral infectivity.
Advances in experimental medicine and biology 1991;306():489-92.
1990: Evnin L B; Vásquez J R; Craik C S
Substrate specificity of trypsin investigated by using a genetic selection.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6659-63.
1990: DesJarlais R L; Seibel G L; Kuntz I D; Furth P S; Alvarez J C; Ortiz de Montellano P R; DeCamp D L; Babé L M; Craik C S
Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6644-8.
1990: Higaki J N; Haymore B L; Chen S; Fletterick R J; Craik C S
Regulation of serine protease activity by an engineered metal switch.
Biochemistry 1990;29(37):8582-6.
1990: Bathurst I C; Moen L K; Lujan M A; Gibson H L; Feucht P H; Pichuantes S; Craik C S; Santi D V; Barr P J
Characterization of the human immunodeficiency virus type-1 reverse transcriptase enzyme produced in yeast.
Biochemical and biophysical research communications 1990;171(2):589-95.
1990: Tomasselli A G; Hui J O; Sawyer T K; Staples D J; Bannow C; Reardon I M; Howe W J; DeCamp D L; Craik C S; Heinrikson R L
Specificity and inhibition of proteases from human immunodeficiency viruses 1 and 2.
The Journal of biological chemistry 1990;265(24):14675-83.
1990: Pichuantes S; Babé L M; Barr P J; DeCamp D L; Craik C S
Recombinant HIV2 protease processes HIV1 Pr53gag and analogous junction peptides in vitro.
The Journal of biological chemistry 1990;265(23):13890-8.
1990: Vanderslice P; Ballinger S M; Tam E K; Goldstein S M; Craik C S; Caughey G H
Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(10):3811-5.
1990: Stewart E A; Craik C S; Hake L; Bowcock A M
Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter.
American journal of human genetics 1990;46(4):795-800.
1990: Ferris A L; Hizi A; Showalter S D; Pichuantes S; Babe L; Craik C S; Hughes S H
Immunologic and proteolytic analysis of HIV-1 reverse transcriptase structure.
Virology 1990;175(2):456-64.
1990: Sigal E; Grunberger D; Highland E; Gross C; Dixon R A; Craik C S
Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related.
The Journal of biological chemistry 1990;265(9):5113-20.
1990: Eakin A E; Bouvier J; Sakanari J A; Craik C S; McKerrow J H
Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites.
Molecular and biochemical parasitology 1990;39(1):1-8.
1990: Sloane D L; Craik C S; Sigal E
The expression of active human reticulocyte 15-lipoxygenase in bacteria.
Biomedica biochimica acta 1990;49(2-3):S11-6.
1989: McGrath M E; Wilke M E; Higaki J N; Craik C S; Fletterick R J
Crystal structures of two engineered thiol trypsins.
Biochemistry 1989;28(24):9264-70.
1989: Higaki J N; Evnin L B; Craik C S
Introduction of a cysteine protease active site into trypsin.
Biochemistry 1989;28(24):9256-63.
1989: Sakanari J A; Staunton C E; Eakin A E; Craik C S; McKerrow J H
Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(13):4863-7.
1989: Vanderslice P; Craik C S; Nadel J A; Caughey G H
Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation.
Biochemistry 1989;28(10):4148-55.
1989: Vasquez J R; Evnin L B; Higaki J N; Craik C S
An expression system for trypsin.
Journal of cellular biochemistry 1989;39(3):265-76.
1989: McGrath M E; Fletterick R J; Craik C S
Rapid preparation of proteins for crystallization trials.
BioTechniques 1989;7(3):246-7.
1989: Pichuantes S; Babé L M; Barr P J; Craik C S
Recombinant HIV1 protease secreted by Saccharomyces cerevisiae correctly processes myristylated gag polyprotein.
Proteins 1989;6(3):324-37.
1989: Sigal E; Craik C S; Dixon R A; Nadel J A
Cloning and expression of human arachidonate 15-lipoxygenase.
Transactions of the Association of American Physicians 1989;102():176-84.
1989: Sigal E; Grunberger D; Craik C S; Caughey G H; Nadel J A
Arachidonate 15-lipoxygenase from human leukocytes: purification and structural homology to other mammalian lipoxygenases.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():156-9.
1988: Sigal E; Craik C S; Highland E; Grunberger D; Costello L L; Dixon R A; Nadel J A
Molecular cloning and primary structure of human 15-lipoxygenase.
Biochemical and biophysical research communications 1988;157(2):457-64.
1988: Gráf L; Hegyi G; Likó I; Hepp J; Medzihradszky K; Craik C S; Rutter W J
Structural and functional integrity of specificity and catalytic sites of trypsin.
International journal of peptide and protein research 1988;32(6):512-8.
1988: Clauser E; Gardell S J; Craik C S; MacDonald R J; Rutter W J
Structural characterization of the rat carboxypeptidase A1 and B genes. Comparative analysis of the rat carboxypeptidase gene family.
The Journal of biological chemistry 1988;263(33):17837-45.
1988: Gardell S J; Craik C S; Clauser E; Goldsmith E J; Stewart C B; Graf M; Rutter W J
A novel rat carboxypeptidase, CPA2: characterization, molecular cloning, and evolutionary implications on substrate specificity in the carboxypeptidase gene family.
The Journal of biological chemistry 1988;263(33):17828-36.
1988: Powell S K; Orci L; Craik C S; Moore H P
Efficient targeting to storage granules of human proinsulins with altered propeptide domain.
The Journal of cell biology 1988;106(6):1843-51.
1988: Sigal E; Grunberger D; Craik C S; Caughey G H; Nadel J A
Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases.
The Journal of biological chemistry 1988;263(11):5328-32.
1988: Sigal E; Grunberger D; Cashman J R; Craik C S; Caughey G H; Nadel J A
Arachidonate 15-lipoxygenase from human eosinophil-enriched leukocytes: partial purification and properties.
Biochemical and biophysical research communications 1988;150(1):376-83.
1988: Evnin L B; Craik C S
Development of an efficient method for generating and screening active trypsin and trypsin variants.
Annals of the New York Academy of Sciences 1988;542():61-74.
1988: Sprang S R; Fletterick R J; Gráf L; Rutter W J; Craik C S
Studies of specificity and catalysis in trypsin by structural analysis of site-directed mutants.
Critical reviews in biotechnology 1988;8(3):225-36.
1987: Craik C S; Roczniak S; Largman C; Rutter W J
The catalytic role of the active site aspartic acid in serine proteases.
Science (New York, N.Y.) 1987;237(4817):909-13.
1987: Sprang S; Standing T; Fletterick R J; Stroud R M; Finer-Moore J; Xuong N H; Hamlin R; Rutter W J; Craik C S
The three-dimensional structure of Asn102 mutant of trypsin: role of Asp102 in serine protease catalysis.
Science (New York, N.Y.) 1987;237(4817):905-9.
1987: Burgess T L; Craik C S; Matsuuchi L; Kelly R B
In vitro mutagenesis of trypsinogen: role of the amino terminus in intracellular protein targeting to secretory granules.
The Journal of cell biology 1987;105(2):659-68.
1987: Fletcher T S; Alhadeff M; Craik C S; Largman C
Isolation and characterization of a cDNA encoding rat cationic trypsinogen.
Biochemistry 1987;26(11):3081-6.
1987: Graf L; Craik C S; Patthy A; Roczniak S; Fletterick R J; Rutter W J
Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin.
Biochemistry 1987;26(9):2616-23.
1987: Craik C S; Roczniak S; Sprang S; Fletterick R; Rutter W
Redesigning trypsin via genetic engineering.
Journal of cellular biochemistry 1987;33(3):199-211.
1987: Ebina Y; Araki E; Taira M; Shimada F; Mori M; Craik C S; Siddle K; Pierce S B; Roth R A; Rutter W J
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(3):704-8.
1987: Higaki J N; Gibson B W; Craik C S
Evolution of catalysis in the serine proteases.
Cold Spring Harbor symposia on quantitative biology 1987;52():615-21.
1985: Gardell S J; Craik C S; Hilvert D; Urdea M S; Rutter W J
Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis.
Nature 1985;317(6037):551-5.
1985: Burgess T L; Craik C S; Kelly R B
The exocrine protein trypsinogen is targeted into the secretory granules of an endocrine cell line: studies by gene transfer.
The Journal of cell biology 1985;101(2):639-45.
1985: Craik C S; Largman C; Fletcher T; Roczniak S; Barr P J; Fletterick R; Rutter W J
Redesigning trypsin: alteration of substrate specificity.
Science (New York, N.Y.) 1985;228(4697):291-7.
1984: Bell G I; Quinto C; Quiroga M; Valenzuela P; Craik C S; Rutter W J
Isolation and sequence of a rat chymotrypsin B gene.
The Journal of biological chemistry 1984;259(22):14265-70.
1984: Swift G H; Craik C S; Stary S J; Quinto C; Lahaie R G; Rutter W J; MacDonald R J
Structure of the two related elastase genes expressed in the rat pancreas.
The Journal of biological chemistry 1984;259(22):14271-8.
1984: Craik C S; Choo Q L; Swift G H; Quinto C; MacDonald R J; Rutter W J
Structure of two related rat pancreatic trypsin genes.
The Journal of biological chemistry 1984;259(22):14255-64.
1983: Craik C S; Rutter W J; Fletterick R
Splice junctions: association with variation in protein structure.
Science (New York, N.Y.) 1983;220(4602):1125-9.
1982: Craik C S; Sprang S; Fletterick R; Rutter W J
Intron-exon splice junctions map at protein surfaces.
Nature 1982;299(5879):180-2.
1981: Craik C S; Buchman S R; Beychok S
O2 binding properties of the product of the central exon of beta-globin gene.
Nature 1981;291(5810):87-90.
1980: Craik C S; Vallette I; Beychok S; Waks M
Refolding defects in hemoglobin Rothschild.
The Journal of biological chemistry 1980;255(13):6219-23.
1980: Craik C S; Buchman S R; Beychok S
Characterization of globin domains: heme binding to the central exon product.
Proceedings of the National Academy of Sciences of the United States of America 1980;77(3):1384-8.

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